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https://www.readbyqxmd.com/read/27915475/how-precisely-can-prostate-cancer-be-managed
#1
REVIEW
Liyan Zhuang, Matthew T Johnson
Progress has been made in applying genetic information to disease management in the postgenomic era, and precision medicine is emerging in prostate cancer management. The prostate health index, the 4-kallikrein (4K) score, and the PCA3, TMPRSS2- ERG, and Prostarix tests have potential for refining prostate cancer screening in conjunction with traditional prostate-specific antigen testing. The Confirm MDx and PCA3 tests have shown promise in identifying men who need be rebiopsied after a primary negative biopsy...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915474/racial-differences-in-the-diagnosis-and-treatment-of-prostate-cancer
#2
REVIEW
Giuliano Di Pietro, Ganna Chornokur, Nagi B Kumar, Chemar Davis, Jong Y Park
Disparities between African American and Caucasian men in prostate cancer (PCa) diagnosis and treatment in the United States have been well established, with significant racial disparities documented at all stages of PCa management, from differences in the type of treatment offered to progression-free survival or death. These disparities appear to be complex in nature, involving biological determinants as well as socioeconomic and cultural aspects. We present a review of the literature on racial disparities in the diagnosis of PCa, treatment, survival, and genetic susceptibility...
November 2016: International Neurourology Journal
https://www.readbyqxmd.com/read/27915390/lifetime-substance-use-as-a-predictor-of-postpartum-mental-health
#3
Betty-Shannon Prevatt, Sarah L Desmarais, Patricia A Janssen
Postpartum mood disorders (PPMD) affect approximately 10-20% of women and have adverse consequences for both mom and baby. Lifetime substance use has received limited attention in relation to PPMD. The present study examined associations of lifetime alcohol and drug use with postpartum mental health problems. Women (n = 100) within approximately 3 months postpartum (M = 2.01, SD = 1.32) participated in semi-structured interviews querying lifetime substance use, mental health history, and postpartum symptoms of anxiety, stress, posttraumatic stress disorder (PTSD), depression, and obsessive compulsive disorder...
December 3, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27915375/identification-of-enzymes-responsible-for-extracellular-alginate-depolymerization-and-alginate-metabolism-in-vibrio-algivorus
#4
Hidetaka Doi, Yuriko Tokura, Yukiko Mori, Kenichi Mori, Yoko Asakura, Yoshihiro Usuda, Hiroo Fukuda, Akito Chinen
Alginate is a marine non-food-competing polysaccharide that has potential applications in biorefinery. Owing to its large size (molecular weight >300,000 Da), alginate cannot pass through the bacterial cell membrane. Therefore, bacteria that utilize alginate are presumed to have an enzyme that degrades extracellular alginate. Recently, Vibrio algivorus sp. SA2(T) was identified as a novel alginate-decomposing and alginate-utilizing species. However, little is known about the mechanism of alginate degradation and metabolism in this species...
December 3, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27915339/clinicopathological-features-and-predictive-factors-for-colorectal-cancer-outcome-in-the-kingdom-of-saudi-arabia
#5
Abdurrahman Aldiab, Khayal A Al Khayal, Omar A Al Obaid, Ahmed Alsheikh, Khalid Alsaleh, Mohamed Shahid, Hana Alkharji
BACKGROUND/AIMS: Colorectal cancer (CRC) is the most frequent cancer and a leading cause of cancer death in the Kingdom of Saudi Arabia (KSA). To date, no nationwide screening programs have been adopted. This prospective, longitudinal study investigated factors influencing the outcome of CRC in Saudi patients. METHODS: Patients completed a CRC awareness questionnaire. Colonoscopy, CT/MRI, histopathology of tumor biopsies, and KRAS and BRAF testing were performed...
December 3, 2016: Oncology
https://www.readbyqxmd.com/read/27915331/screening-of-bioactive-ingredients-in-ligusticum-chuanxiong-hort-for-protection-against-myocardial-ischemia
#6
Xu Liu, Xiuzhong Li, Songgang Ji, Xiaobo Cui, Mingchun Li
BACKGROUND/AIMS: To study the spectrum-effect relationship and effective components of Ligusticum Chuanxiong Hort. (LCH) on the protection of canine myocardial ischemia. METHODS: Fingerprint spectrum of LCH extracts was developed using high performance liquid chromatography (HPLC), and a canine model of acute myocardial ischemia was established by ligating the coronary artery. Bivariate correlation analysis and multivariate regression analysis were used to correlate the pharmacodynamics of LCH extract and its common peaks in HPLC...
December 5, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915327/posterior-retinal-hemorrhages-during-retcam-examination-for-retinopathy-of-prematurity
#7
Parijat Chandra, Rajvardhan Azad
BACKGROUND: Retcam-assisted retinopathy of prematurity (ROP) screening is a commonly used safe examination procedure. CASE CHARACTERISTICS: A preterm baby born at 32 weeks gestation age developed extensive posterior retinal hemorrhages during retinal imaging using the RetCam. OUTCOME: Retinal hemorrhages spontaneously resolved. MESSAGE: As tele screening is becomes more popular, proper training for Retcam usage is essential...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915324/improving-follow-up-of-infants-during-retinopathy-of-prematurity-screening-in-rural-areas
#8
Anand Vinekar, Chaitra Jayadev, Mangat Dogra, Bhujang Shetty
OBJECTIVE: To evaluate the challenges of completing and improving follow-up in an retinopathy of prematurity (ROP) screening program in rural centers. METHODS: Reasons for dropout from a multi-center ROP screening program in rural Karnataka, over two six-month periods, were collected and categorized. Improvement measures introduced between the two periods and its impact was analyzed. RESULTS: Reasons pertaining to travel and logistics (15 of 53, 28...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915321/anti-vascular-endothelial-growth-factor-preparations-in-the-treatment-of-retinopathy-of-prematurity-balancing-risks-and-benefits
#9
Deepak Chawla, Brian A Darlow
NEED AND PURPOSE OF REVIEW: The standard of management of severe retinopathy of prematurity (ROP) is laser ablation of the peripheral retina. Intra-vitreal injection of anti- vascular endothelial growth factor antibodies has emerged as an alternative modality of treatment of ROP. The purpose of this review is to evaluate the current evidence on benefits and risks of using anti-VEGF antibodies for management of ROP. METHODS: PubMed and Cochrane Register of Clinical Trials were searched for studies evaluating role of anti-VEGF agents in ROP...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915320/retinopathy-of-prematurity-aiims-new-delhi-experience
#10
Sindhu Sivanandan, Parijat Chandra, Ashok K Deorari, Ramesh Agarwal
Retinopathy of prematurity (ROP) is a leading cause of potentially avoidable childhood blindness worldwide. With improvement in neonatal care, more preterm infants are surviving with a resultant increase in the number of ROP cases. In low-middle income countries, the disease epidemiology is characterized by the occurrence of ROP at higher birthweight in premature babies with greater severity at presentation. In this article, we describe the ROP screening and management program at the All India Institute of Medical Sciences (AIIMS), New Delhi that has evolved over last three decades...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915319/retinopathy-of-prematurity-clinical-features-classification-natural-history-management-and-outcome
#11
Parag K Shah, Vishma Prabhu, Ratnesh Ranjan, Venkatapathy Narendran, Narendran Kalpana
CONTEXT: Retinopathy of prematurity is an avoidable cause of childhood blindness. Proper understanding of the classification and treatment methods is a must in tackling this disease. EVIDENCE ACQUISITION: Literature search with PubMed was conducted covering the period 1940-2015 with regards to retinopathy of prematurity, retrolental fibroplasia, its natural history, classification and treatment. RESULTS: The clinical features, screening and staging of retinopathy of prematurity according to International classification of retinopathy of prematurity (ICROP) has been included with illustrations...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915318/services-for-the-detection-and-treatment-of-retinopathy-of-prematurity-in-major-indian-cities-the-11-city-9-state-study
#12
Clare Gilbert, Rajan Shukla, Rakesh Kumar, Ajay Khera, G Vs Murthy
OBJECTIVE: Control of visual loss from retinopathy of prematurity requires high quality neonatal care, and timely screening and treatment of sight-threatening disease. We assessed services for retinopathy of prematurity provided by ophthalmic training institutions in major Indian cities. METHODS: Eleven cities were purposefully selected and eye-care facilities were evaluated using predefined criteria. Field teams visited these facilities to collect data by interview and observation using structured questionnaires...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915317/initiating-retinopathy-of-prematurity-screening-before-discharge-from-the-neonatal-care-unit-effect-on-enrolment-in-rural-india
#13
Anand Vinekar, Chaitra Jayadev, Shwetha Mangalesh, Mathew Kurian, Mangat Dogra, Noel Bauer, Bhujang Shetty
OBJECTIVE: To compare the benefits of initiating Retinopathy of Prematurity (ROP) screening at first contact with the admitted infant prior to hospital discharge ('early screening') with screening performed between 21 and 28 days after birth ('conventional screening') in rural India. DESIGN: Prospective study. SETTING: Two Level II neonatal intensive care units (NICU), from two district headquarters in Karnataka state. PARTICIPANTS: Participants: 329 infants admitted in the two NICUs...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915316/lack-of-screening-underlies-most-stage-5-retinopathy-of-prematurity-among-cases-presenting-to-a-tertiary-eye-center-in-india
#14
Rajvardhan Azad, Parijat Chandra, Anil Gangwe, Vivek Kumar
OBJECTIVE: To study the barriers to effective screening, early detection and treatment of Retinopathy of Prematurity leading to advanced disease. DESIGN: Cross-sectional study. SETTING: Tertiary eye care hospital in northern India. PARTICIPANTS: 115 babies with bilateral stage 5 ROP identified amongst 354 preterm infants examined over a one year period. METHODS: Information regarding gestational age, birthweight, duration of stay in nursery, duration of supplemental oxygen therapy and treatment details were obtained from discharge summary when available, and by interviewing carers...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915314/programs-for-detecting-and-treating-retinopathy-of-prematurity-role-of-the-neonatal-team
#15
Sudhanshu Grover, Deeksha Katoch, Mangat R Dogra, Praveen Kumar
High quality perinatal-neonatal care can prevent severe Retinopathy of Prematurity (ROP) in most cases. Preterm infants who do develop retinopathy can also have good visual outcomes if screening and treatment are done timely. National Neonatology Forum published clinical practice guidelines for timely screening and treatment of ROP in neonatal care units in the country in 2010. It is also listed as one of the condition under Rashtriya Bal Swasthya Karyakram for early identification and early intervention, and is currently a focus area under the National Program for Control of Blindness...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915313/update-on-blindness-due-to-retinopathy-of-prematurity-globally-and-in-india
#16
Hannah Blencowe, Sarah Moxon, Clare Gilbert
Retinopathy of prematurity (ROP), a well-known complication of preterm birth that can result in avoidable blindness and visual impairment, is especially sensitive to the quality of neonatal inpatient care and appropriate, well-monitored oxygen. In 2010, the annual incidence of blindness and visual impairment from ROP was estimated to be 32,200 cases worldwide. The greatest burden is seen in middle-income countries, particularly where coverage of neonatal inpatient care has expanded without due attention to the quality of care provided, and the neonatal nursing skills and training of those providing this care...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915312/role-of-retinopathy-of-prematurity-rop-tertiary-centers-of-excellence-in-capacity-building
#17
Padmaja Kumari Rani, D Balakrishnanan, T R Padhi, Subhadra Jalali
Tertiary Centres of Excellence in India have been at the forefront of the efforts against Retinopathy of Prematurity (ROP) - associated blindness. The epidemic of blindness from ROP; however, has now spread rapidly into large parts of interiors of developing countries due to improved newborn care facilities. Due to their knowledge and experience of more than a decade, these centres of excellence, both from child care and Ophthalmology care, now need to come forward in substantial measures and need to be supported by funds and programs so that concerns of neonatal eye-health, training, screening, prevention and treatment can get integrated and embedded into newborn critical care and health programs...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915311/can-we-stop-the-current-epidemic-of-blindness-from-retinopathy-of-prematurity
#18
Sourabh Dutta, Talkad Raghuveer, Anand Vinekar, Mangat Ram Dogra
Retinopathy of Prematurity (ROP) is a retinal vascular disease of the premature infant. There have been significant advances in the understanding of the pathogenesis, prevention, detection and treatment of severe ROP. In developed countries, all premature infants at risk for ROP are screened routinely based on national guidelines and treatment is prompt, resulting in good visual outcomes. Blindness from ROP is a rare event in these countries. However, there is an ongoing epidemic of ROP- induced blindness in India...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915310/retinopathy-of-prematurity-profile-and-trend-over-the-years-experience-from-a-two-tier-city-in-eastern-india
#19
Tapas Ranjan Padhi, Lubhani Jain, Umesh Chandra Behera, Lingaraj Pradhan
The Retinopathy of Prematurity (ROP) epidemic is no more confined to metro cities and has spread to interior states including Eastern India. There is hardly any published data available on the subject, including the incidence and profile of babies with ROP, screening experience with binocular indirect ophthalmoscope and wide-field digital retinal imaging, as well as the difficulties faced with each model. In our cohort, 33.2% had ROP and 25.3% of babies with ROP required treatment. Mean (SD) gestational age and birth weight were 30...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27915263/c-reactive-protein-and-risk-of-atrial-fibrillation-in-east-asians
#20
Chang Hee Kwon, Jung Gyu Kang, Hyun Jong Lee, Nan Hee Kim, Joo-Wook Sung, EunSun Cheong, Ki-Chul Sung
AIMS: Inflammation has been suggested to play a role in the pathogenesis of atrial fibrillation (AF). It is uncertain whether C-reactive protein, a robust inflammatory marker, is associated with AF incidence in Asians with lower levels of C-reactive protein compared with western population. This study aimed to determine the association between C-reactive protein and risk of AF in a large population of Koreans. METHODS AND RESULTS: A total of 402 946 Koreans were enrolled in a health screening programme from January 2002 to December 2013...
December 2, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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