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https://www.readbyqxmd.com/read/29679924/military-status-and-alcohol-problems-former-soldiers-may-be-at-greater-risk
#1
Bonnie M Vest, D Lynn Homish, Jennifer Fillo, Gregory G Homish
OBJECTIVES: The goal of this study was to explore differences in alcohol problems as a function of military status (current soldier, previous soldier and civilian spouses), and the possible interaction between sex and military status. We hypothesized that 1) soldiers would be at greater risk for alcohol problems than civilian spouses, and 2) former soldiers would be at greater risk compared to current soldiers. METHODS: Data were drawn from Operation: SAFETY, a longitudinal study examining physical and mental health among U...
April 13, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29679907/in-vitro-screening-homology-modeling-and-molecular-docking-studies-of-some-pyrazole-and-imidazole-derivatives
#2
Farid Abrigach, Yahya Rokni, Abdelilah Takfaoui, Mohamed Khoutoul, Henri Doucet, Abdeslam Asehraou, Rachid Touzani
A series of synthesized compounds based on pyrazole and imidazole skeletons prepared by palladium catalysts via a one-pot reaction was screened to determine their inhibitory potency against the pathogen fungus Fusarium oxysporum f.sp. albedinis (F.o.a) and four bacteria strains namely Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus and Escherichia coli. The obtained result showed that these compounds exhibit an efficiency antifungal action. Whereas, they showed a very weak antibacterial activity...
April 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29679902/new-lipophilic-isoniazid-derivatives-and-their-1-3-4-oxadiazole-analogues-synthesis-antimycobacterial-activity-and-investigation-of-their-mechanism-of-action
#3
Rudolf Vosátka, Martin Krátký, Markéta Švarcová, Jiří Janoušek, Jiřina Stolaříková, Jan Madacki, Stanislav Huszár, Katarína Mikušová, Jana Korduláková, František Trejtnar, Jarmila Vinšová
The development of novel drugs is essential for the treatment of tuberculosis and other mycobacterial infections in future. A series of N-alkyl-2-isonicotinoylhydrazine-1-carboxamides was synthesized from isoniazid (INH) and then cyclized to N-alkyl-5-(pyridin-4-yl)-1,3,4-oxadiazole-2-amines. All derivatives were characterised spectroscopically. The compounds were screened for their in vitro antimycobacterial activity against susceptible and multidrug-resistant Mycobacterium tuberculosis (Mtb.) and nontuberculous mycobacteria (NTM; M...
April 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29679900/structural-insights-into-serotonin-receptor-ligands-polypharmacology
#4
Sabina Podlewska, Rafał Kafel, Enza Lacivita, Grzegorz Satała, Albert J Kooistra, Márton Vass, Chris de Graaf, Marcello Leopoldo, Andrzej J Bojarski, Stefan Mordalski
Identifying desired interactions with a target receptor is often the first step when designing new active compounds. However, attention should also be focused on contacts with other proteins that result in either selective or polypharmacological compounds. Here, the search for the structural determinants of selectivity between selected serotonin receptor subtypes was carried out. Special attention was focused on 5-HT7 R and the cross-interactions between its ligands and the 5-HT1A R, 5-HT1B R, 5-HT2A R, 5-HT2B R, and 5-HT6 R subtypes...
April 6, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29679883/protective-effects-of-stigmasterol-against-ketamine-induced-psychotic-symptoms-possible-behavioral-biochemical-and-histopathological-changes-in-mice
#5
Monu Yadav, Milind Parle, Deepak Kumar Jindal, Sameer Dhingra
BACKGROUND: Stigmasterol, a naturally occurring phytoestrogen has been reported to possess many pharmacological activities. The aim of the present study was to screen the effect of stigmasterol against ketamine-induced mice model of psychosis. METHODS: The behavioural studies included an assessment of locomotor activity, stereotypic behaviours, immobility duration, step down latency and effects on catalepsy. Biochemical estimations involved the estimations of GABA, dopamine, GSH, MDA, TNF-α, total protein content and AChE activity...
January 11, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29679863/discovery-of-new-gyrase-%C3%AE-inhibitors-via-structure-based-modeling
#6
Afaf H Al-Nadaf, Sajeda A Salah, Mutasem O Taha
Gyrase B is an essential enzyme in the prokaryotes which became an attractive target for antibacterial agents. In our study, we implemented a wide range of docking configurations to dock 120 inhibitors into the in the ATP- binding pocket of Gyrase B enzyme (PDB code: 4GEE). LigandFit docking engines and six scoring functions were utilized in the study. Furthermore, the ligands were docked in their ionized and unionized forms into the hydrous and anhydrous binding pocket. We used docking-based Comparative Intermolecular Contacts Analysis (db-CICA) which is a novel methodology to validate and identify the optimal docking configurations...
March 19, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29679839/xenon-detection-in-human-blood-analytical-validation-by-accuracy-profile-and-identification-of-critical-storage-parameters
#7
Cécile Frampas, Julia Ney, Mark Coburn, Marc Augsburger, Vincent Varlet
Xenon is a rare, mostly inert, noble gas that has applications in a wide range of fields, including medicine. Xenon acts on the human body as a useful organ-protective and anesthetic agent and has also been previously studied for potential applications in fields such as optics, aerospace and medical imaging. Recently, it was discovered that xenon can boost erythropoietin production, and it has been used as a performance-enhancing agent in international sports competitions such as the Sochi Olympic Games. Therefore, screening methods to detect the misuse of xenon by analysis of biological samples and to monitor anesthesia kinetics and efficiency are being investigated...
April 13, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29679778/recapitulating-spatiotemporal-tumor-heterogeneity-in-vitro-through-engineered-breast-cancer-microtissues
#8
Claudia Mazio, Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Paolo Antonio Netti
Tumor and microenvironmental heterogeneity hinders the study of breast cancer biology and the assessment of therapeutic strategies, being associated with high variability and drug resistance. In this context, it is mandatory to develop three-dimensional breast tumor models able to reproduce this heterogeneity and the dynamic interaction occurring between tumor cells and microenvironment. Here we show a new breast cancer microtissue model (T-µTP) uniquely able to present intra-tumor morphological heterogeneity in a dynamic and responsive endogenous matrix...
April 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29679777/integrating-microbial-biomass-composition-and-function-to-discern-the-level-of-anthropogenic-activity-in-a-river-ecosystem
#9
Kailingli Liao, Yaohui Bai, Yang Huo, Zhiyu Jian, Wanchao Hu, Chen Zhao, Jiuhui Qu
Anthropogenic activities (e.g., wastewater discharge and pesticide and fertilizer use) have considerable impact on the biotic properties of natural aquatic ecosystems, especially the microbial community and function. Microbes can respond to anthropogenic activities and are thus potential indicators of activity levels. Several reports have documented the impacts of anthropogenic activities on the variations in the microbial community, but the direct use of microbial community indices to discern anthropogenic activity levels remains limited...
April 18, 2018: Environment International
https://www.readbyqxmd.com/read/29679769/infection-status-and-risk-factors-associated-with-urinary-schistosomiasis-among-school-going-children-in-the-ndumo-area-of-umkhanyakude-district-in-kwazulu-natal-south-africa-two-years-post-treatment
#10
Muhubiri Kabuyaya, Moses John Chimbari, Samson Mukaratirwa
OBJECTIVES: To assess the efficacy of praziquantel of infected children with Schistosoma haematobium over a 2year period in the Ndumo area of uMkhanyakude district, South Africa. METHODS: This cohort study enrolled 173 school-going children in September 2017 that participated in a baseline survey conducted in 2015 in the Ndumo area. Questionnaire interviews were conducted to collect information on the risk factors related to transmission of schistosomiasis and filtration technique was performed to detect Schistosoma haematobium eggs in urine...
April 18, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29679758/validation-and-bioinformatic-analysis-of-propofol-induced-differentially-expressed-micrornas-in-primary-cultured-neural-stem-cells
#11
Yan Li, Youtan Liu, Jun Fan, Quan Zhou, Xiuling Song, Zhiyong Peng, Zaisheng Qin, Tao Tao
Propofol, a widely used intravenous anesthetic, was previously considered as a neuroprotective agent. Recently, however, accumulating evidence suggests that it may cause neurotoxicity, especially in the development of neural stem cells (NSCs). The potential mechanisms contributing to propofol-induced neurotoxicity during neurogenesis, such as those involving microRNAs (miRNAs), are still unknown. In this study, a total of 27 differentially expressed miRNAs were identified in our initial screen and 6 miRNAs were validated by qRT-PCR...
April 18, 2018: Gene
https://www.readbyqxmd.com/read/29679712/evaluating-the-genotoxicity-of-cellulose-nanofibrils-in-a-co-culture-of-human-lung-epithelial-cells-and-monocyte-derived-macrophages
#12
Célia Ventura, Ana Filipa Lourenço, António Sousa-Uva, Paulo J T Ferreira, Maria João Silva
Cellulose nanofibrils (CNF) are manufactured nanofibres that hold impressive expectations in forest, food, pharmaceutical, and biomedical industries. CNF production and applications are leading to an increased human exposure and thereby it is of utmost importance to assess its safety to health. In this study, we screened the cytotoxic, immunotoxic and genotoxic effects of a CNF produced by TEMPO-mediated oxidation of an industrial bleached Eucalyptus globulus kraft pulp on a co-culture of lung epithelial alveolar (A549) cells and monocyte-derived macrophages (THP-1 cells)...
April 18, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29679698/neurophysiological-and-neuroradiological-multimodal-approach-for-early-poor-outcome-prediction-after-cardiac-arrest
#13
Maenia Scarpino, Giovanni Lanzo, Francesco Lolli, Riccardo Carrai, Marco Moretti, Maddalena Spalletti, Morena Cozzolino, Adriano Peris, Aldo Amantini, Antonello Grippo
INTRODUCTION: Prognosticating outcome after cardiac arrest(CA) requires a multimodal approach. However, evidence regarding combinations of methods is limited. We evaluated whether the combination of electroencephalography(EEG), somatosensory evoked potentials(SEPs) and brain computed tomography(CT) could predict poor outcome. METHODS: We screened our database regarding patients successfully resuscitated after CA, for whom EEG, SEPs and brain CT were available within 24 hours...
April 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29679640/cepfostering-efficacy-and-toxicity-evaluation-of-traditional-chinese-medicine-and-natural-products
#14
REVIEW
Tong Wu, Gui-Yuan Yu, Jia Xiao, Chang Yan, Hiroshi Kurihara, Yi-Fang Li, Kwok-Fai So, Rong-Rong He
Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack of physiological environment. Within the avian species, chick is the first bird to have its genome sequencing. Meantime, chick embryo is an easily operating, relatively transparent and extensively accessible model, whose physiological and pathological alterations can be visualized by egg candler, staining and image technologies...
April 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29679617/retinopathy-of-prematurity-a-review-of-risk-factors-and-their-clinical-significance
#15
REVIEW
Sang Jin Kim, Alexander D Port, Ryan Swan, J Peter Campbell, R V Paul Chan, Michael F Chiang
Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors...
April 19, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679584/remember-the-vessels-craniofacial-fracture-predicts-risk-for-blunt-cerebrovascular-injury
#16
Elina Varjonen, Frank Bensch, Tuomo Pyhältö, Mika Koivikko, Johanna Snäll
PURPOSE: The risk factors for blunt cerebrovascular injuries (BCVIs) are currently under intensive research, yet it is still controversial who should be screened. This study aimed to determine whether craniofacial fractures are associated with BCVI. PATIENTS AND METHODS: This retrospective cohort study focused on patients with suspected polytrauma after whole-body computed tomographic angiography of the cervical arteries. Patients were reviewed for BCVI and craniofacial fractures...
March 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29679561/drosophila-nucleostemin-3-is-required-to-maintain-larval-neuroblast-proliferation
#17
Patrick W Johnson, Chris Q Doe, Sen-Lin Lai
Stem cells must maintain proliferation during tissue development, repair and homeostasis, yet avoid tumor formation. In Drosophila, neural stem cells (neuroblasts) maintain proliferation during embryonic and larval development and terminate cell cycle during metamorphosis. An important question for understanding how tissues are generated and maintained is: what regulates stem cell proliferation versus differentiation? We performed a genetic screen which identified nucleostemin 3 (ns3) as a gene required to maintain neuroblast proliferation...
April 18, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29679497/ewsr1-patz1-gene-fusion-may-define-a-new-glioneuronal-tumor-entity
#18
Aurore Siegfried, Audrey Rousseau, Claude-Alain Maurage, Sarah Pericart, Yvan Nicaise, Frederic Escudie, David Grand, Alix Delrieu, Anne Gomez-Brouchet, Sophie Le Guellec, Camille Franchet, Sergio Boetto, Matthieu Vinchon, Jean-Christophe Sol, Franck-Emmanuel Roux, Valerie Rigau, Anne-Isabelle Bertozzi, David Tw Jones, Dominique Figarella-Branger, Emmanuelle Uro-Coste
We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N terminal transcriptional activation domain of EWSR1 gene and the C terminal DNA binding domain of a transcription factor gene, PATZ1...
April 21, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29679480/association-between-online-information-seeking-and-adherence-to-guidelines-for-breast-and-prostate-cancer-screening
#19
Hankyul Kim, Christopher Filson, Peter Joski, Silke von Esenwein, Joseph Lipscomb
INTRODUCTION: From 2012 through 2014, the US Preventive Services Task Force (USPSTF) recommended biennial mammography for women aged 50 to 75 and recommended against the prostate specific antigen (PSA) test for men of any age, emphasizing informed decision making for patients. Because of time constraints and other patient health priorities, health care providers often do not discuss benefits and risks associated with cancer screening. We analyzed the association between seeking information online about breast and prostate cancer and undergoing mammography and PSA screening...
April 19, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29679452/multidimensional-patient-impression-of-change-following-interdisciplinary-pain-management
#20
Christine M Gagnon, Paul Scholten, James Atchison
OBJECTIVES: To assess patient impression of change following interdisciplinary pain management utilizing a newly developed Multidimensional Patient Impression of Change (MPIC) questionnaire. METHODS: A heterogeneous group of chronic pain patients (N = 601) participated in an interdisciplinary treatment program. Programs included individual and group therapies (pain psychology, physical therapy, occupational therapy, relaxation training/biofeedback, aerobic conditioning, patient education and medical management)...
April 20, 2018: Pain Practice: the Official Journal of World Institute of Pain
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