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https://www.readbyqxmd.com/read/29908474/early-warnings-for-suicide-attempt-among-chinese-rural-population
#1
Juncheng Lyu, Yingying Wang, Hong Shi, Jie Zhang
OBJECTIVE: This study was to explore the main influencing factors of attempted suicide and establish an early warning model, so as to put forward prevention strategies for attempted suicide. METHOD: Data came from a large-scale case-control epidemiological survey. A sample of 659 serious suicide attempters was randomly recruited from 13 rural counties in China. Each case was matched by a community control for gender, age, and residence location. Face to face interviews were conducted for all the cases and controls with the same structured questionnaire...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29908454/hydrogen-ions-and-organic-acids-secreted-by-ectomycorrhizal-fungi-pisolithus-sp1-are-involved-in-the-efficient-removal-of-hexavalent-chromium-from-waste-water
#2
Liang Shi, Jiawang Xue, Binhao Liu, Pengcheng Dong, Zhugui Wen, Zhenguo Shen, Yahua Chen
Pisolithus sp1 is an ectomycorrhizal (ECM) fungi that was chosen during a screening test of six strains of ECM fungi due to its ability to tolerate and remove hexavalent chromium (Cr(VI)). The physiological responses of Pisolithus sp1 to Cr(VI) exposure, the relationship between Pisolithus sp1 and exogenously added organic acids (EAOAs) or Na3 VO4 (H+ -ATPase inhibitor) and the ability of Pisolithus sp1 to reduce Cr(VI) in liquid culture were also investigated. Hydrogen ions (H+ ), which were produced directly by Pisolithus sp1, reduced the pH of the medium and played an important role in Cr(VI) reduction; however, Na3 VO4 significantly inhibited this process and resulted in a decrease in the Cr(VI) reduction rates...
June 13, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29908446/predicting-aged-pork-quality-using-a-portable-raman-device
#3
C C Santos, J Zhao, X Dong, S M Lonergan, E Huff-Lonergan, A Outhouse, K B Carlson, K J Prusa, C A Fedler, C Yu, S D Shackelford, D A King, T L Wheeler
The utility of Raman spectroscopic signatures of fresh pork loin (1 d & 15 d postmortem) in predicting fresh pork tenderness and slice shear force (SSF) was determined. Partial least square models showed that sensory tenderness and SSF are weakly correlated (R2  = 0.2). Raman spectral data were collected in 6 s using a portable Raman spectrometer (RS). A PLS regression model was developed to predict quantitatively the tenderness scores and SSF values from Raman spectral data, with very limited success...
May 29, 2018: Meat Science
https://www.readbyqxmd.com/read/29908444/synthesis-and-biological-evaluation-of-novel-2-oxo-1-2-dihydroquinoline-4-carboxamide-derivatives-for-the-treatment-of-esophageal-squamous-cell-carcinoma
#4
Mai I Shahin, Joyeeta Roy, Maha Hanafi, Dongyao Wang, Urarika Luesakul, Yifeng Chai, Nongnuj Muangsin, Deena S Lasheen, Dalal A Abou El Ella, Khaled A Abouzid, Nouri Neamati
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines...
May 29, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908441/synthesis-and-biological-evaluation-of-new-coumarins-bearing-2-4-diaminothiazole-5-carbonyl-moiety
#5
Adileh Ayati, Tayebeh Oghabi Bakhshaiesh, Setareh Moghimi, Rezvan Esmaeili, Keivan Majidzadeh-A, Maliheh Safavi, Loghman Firoozpour, Saeed Emami, Alireza Foroumadi
A series of new coumarin-containing compounds 3a-l and 4a-c was designed and synthesized based on the chalcone-type 4-amino-5-cinnamoylthiazole scaffold 2, and screened for their in vitro anticancer and antioxidant activities. Representatively, the 2-thiomorpholinothiazole derivative 3k with IC50 values of 7.5-16.9 μg/ml demonstrated good cytotoxic effects against tested cell lines MCF-7, HepG2 and SW480. Further investigation by flow cytometric analysis confirmed that this compound induces apoptotic cell death in MCF-7 cells and cause G1-phase arrest in the cell cycle...
June 7, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908386/anxiety-is-common-and-independently-associated-with-clinical-features-of-epilepsy
#6
Heidi M Munger Clary, Beverly M Snively, Marla J Hamberger
OBJECTIVE: The objective of this study was to assess for independent association of anxiety symptoms with epilepsy localization and other epilepsy-related and demographic factors in a large tertiary care adult epilepsy population. METHODS: Among 540 adults, anxiety was measured by the Symptom Checklist 90-R (SCL-90R) anxiety subscale, and detailed demographics, epilepsy localization, and depression scores (SCL-90R) were collected. High anxiety was defined by SCL-90R anxiety T-score ≥ 60...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29908384/assessing-depression-severity-with-a-self-rated-vs-rater-administered-instrument-in-patients-with-epilepsy
#7
Shirin Jamal-Omidi, Christine Collins, Erin Fulchiero, Hongyan Liu, Kari Colon-Zimmermann, Edna Fuentes-Casiano, Curtis Tatsuoka, Kristin A Cassidy, Samden Lhatoo, Martha Sajatovic
RATIONALE: Up to 30-50% of individuals with epilepsy have depressive symptoms, which often complicate seizure management and reduce overall quality of life. To identify and manage depressive symptoms appropriately, clinicians need standardized instruments that can accurately identify and monitor those with clinically significant depression. The self-reported 9-item Patient Health Questionnaire (PHQ-9) has been used relatively widely to screen and monitor depression in epilepsy. The rater-administered Montgomery-Asberg Depression Rating Scale (MADRS) is a rater-administered instrument widely used in depression treatment trials but less widely applied in epilepsy...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29908352/man1b-cdg-novel-variants-with-a-distinct-phenotype-and-review-of-literature
#8
Meena Balasubramanian, Diana S Johnson
BACKGROUND: Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases due to impaired lipid and protein glycosylation. It comprises a characteristic high frequency of intellectual disability (ID) and a wide range of clinical phenotypes. OBJECTIVE: (s): To identify the underlying diagnosis in two families each with two siblings with variable level of ID through trio whole exome sequencing. METHODS: Both the families were recruited to the Deciphering Developmental Disorders (DDD) study to identify the aetiology for their ID...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908349/mr-diffusion-kurtosis-imaging-for-cancer-diagnosis-a-meta-analysis-of-the-diagnostic-accuracy-of-quantitative-kurtosis-value-and-diffusion-coefficient
#9
Lu Shen, Guoxing Zhou, Fei Tang, Yi Lin, Jie Zhou, Pinshuo Lv, Yibin Wang, Genlin Zong, Jiangmin Zhao
PURPOSE: To perform a meta-analysis for assessing the accuracy of diffusion kurtosis imaging (DKI)-derived quantitative parameters (kurtosis values, K; and corrected diffusion coefficients non-Gaussian bias, D) in separating malignant cancers from benign lesions. METHODS: Relevant studies were searched in PubMed and Cochrane Library databases and were analyzed by Meta-DiSc software. RESULTS: Fourteen eligible studies involving 1847 lesions in 1107 patients (895 were benign and 952 were malignant) were included...
June 9, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29908330/a-preliminary-study-for-the-development-and-optimization-by-experimental-design-of-an-in-vitro-method-for-prediction-of-drug-buccal-absorption
#10
Paola Mura, Serena Orlandini, Marzia Cirri, Francesca Maestrelli, Natascia Mennini, Giada Casella, Sandra Furlanetto
The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp ) through excised porcine buccal mucosa of naproxen, selected as model drug, was the target value to obtain with the artificial membrane. The multivariate approach enabled systematic evaluation of the effect on the response (Papp ) of simultaneous variations of the variables (kind of lipid components for support impregnation and relative amounts)...
June 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29908287/characterization-of-nanomedicines-surface-coverage-using-molecular-probes-and-capillary-electrophoresis
#11
J-B Coty, F Varenne, A Benmalek, O Garsaa, I Le Potier, M Taverna, C Smadja, C Vauthier
A faithful characterization of nanomedicine (NM) is needed for a better understanding of their in vivo outcomes. Size and surface charge are studied with well-established methods. However, other relevant parameters for the understanding of NM behavior in vivo remain largely inaccessible. For instance, the reactive surface of nanomedicines, which are often grafted with macromolecules to decrease their recognition by the immune system, is excluded from a systematic characterization. Yet, it is known that a subtle modification of NM's surface characteristics (grafting density, molecular architecture and conformation of macromolecules) is at the root of major changes in the presence of biological components...
June 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29908272/a-novel-solvent-tolerant-esterase-of-gdsgg-motif-subfamily-from-solar-saltern-through-metagenomic-approach-recombinant-expression-and-characterization
#12
G Jayanath, Sowmya P Mohandas, Bhavya Kachiprath, Solly Solomon, T P Sajeevan, I S Bright Singh, Rosamma Philip
A novel esterase, designated as EstSP was identified by function based screening from a soil metagenomic fosmid library of solar saltern of Goa. EstSP gene of 1065 bp encoding a putative esterase of 354 amino acids showing 55% identity to esterase from gamma proteobacterium HIMB55 was identified. The enzyme EstSP belongs to family IV hormone sensitive lipase with novel sequence characteristics and a unique motif GDSGG. EstSP was expressed in Escherichia coli and purified protein with molecular mass of 58...
June 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29908178/new-generation-full-spectrum-endoscopy-versus-standard-forward-viewing-colonoscopy-a-multicenter-randomized-tandem-colonoscopy-trial-j-fuse-study
#13
Toyoki Kudo, Yutaka Saito, Hiroaki Ikematsu, Kinichi Hotta, Yoji Takeuchi, Masaaki Shimatani, Ken Kawakami, Naoto Tamai, Yuichi Mori, Yasuharu Maeda, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Kenichiro Imai, Sayo Ito, Kenta Hamada, Norimasa Fukata, Takuya Inoue, Hisao Tajiri, Kenichi Yoshimura, Hideki Ishikawa, Shin-Ei Kudo
OBJECTIVES: Although colonoscopy is the criterion standard for detection of colorectal adenomas, some adenomas are missed. Full-spectrum endoscopy (FUSE) allows for observation with a 330° angle of view, which is expected to decrease the miss rate. However, no consensus has been reached regarding the superiority of FUSE over standard forward-viewing colonoscopy (SFVC) for detection of adenomas; we therefore compared new-generation FUSE and SFVC regarding colorectal adenoma miss rate (AMR) in this, the first reported randomized control trial using new-generation FUSE...
June 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29908171/screening-of-natural-wolbachia-infection-in-aedes-aegypti-aedes-taeniorhynchus-and-culex-quinquefasciatus-from-guadeloupe-french-west-indies
#14
D Goindin, A Cannet, C Delannay, C Ramdini, J Gustave, C Atyame, A Vega-Rúa
Guadeloupe islands are threatened by several mosquito-borne viruses such as Dengue, Chikungunya, Zika and West Nile virus. It appears essential to look for alternative mosquito control methods such as the incompatible insect technique (ITT) aiming at sterilizing wild females by inundative releases of incompatible males. Before considering the implementation of such a strategy, the characterization of genetic diversity of the endocellular bacterium Wolbachia regarding the local mosquito populations is a critical issue...
June 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29908157/a-novel-electrochemical-dna-biosensor-for-ebola-virus-detection
#15
Hoda Ilkhani, Siamak Farhad
The aim of this study was to fabricate a novel electrochemical-based DNA-sensing device for Ebola virus DNA diagnostic by an enzyme-amplified detection, which improves the sensitivity and selectivity of the sensor. A thiolated DNA capture probe sequence was immobilized on the screen printed electrode surface and hybridized with biotinylated target strand DNA for the fabrication of Ebola DNA-sensing devices. Prior to the electrochemical detection of the enzymatic product by differential pulse voltammetry (DPV) method, the biotinylated hybrid was labelled with a streptavidin-alkaline phosphate conjugate on the surface of the working electrode...
June 13, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29908097/n-n-bis-2-mercaptoethyl-isophthalamide-binds-electrophilic-paracetamol-metabolites-and-prevents-paracetamol-induced-liver-toxicity
#16
Johan L Å Nilsson, Anders Blomgren, Ulf J Nilsson, Edward D Högestätt, Lars Grundemar
Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N-acetyl-p-benzoquinone imine (NAPQI) and p-benzoquinone (p-BQ). Herein, the chelating agent, N,N'-Bis(2-mercaptoethyl)isophthalamide (NBMI), was examined for its potential ability to entrap NAPQI and p-BQ and to prevent paracetamol-induced liver injury. Both NBMI and the conventional paracetamol antidote N-Acetyl cysteine (NAC) were investigated with regard to their abilities to scavenge the NAPQI and p-BQ in a Transient Receptor Potential Ankyrin 1 (TRPA1)-dependent screening assay...
June 16, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29908092/a-novel-ptch1-mutation-underlies-non-syndromic-cleft-lip-and-or-palate-in-a-han-chinese-family
#17
Huaxiang Zhao, Wenjie Zhong, Chuntao Leng, Jieni Zhang, Mengqi Zhang, Wenbin Huang, Yunfan Zhang, Weiran Li, Peizeng Jia, Jiuxiang Lin, Gulibaha Maimaitili, Feng Chen
OBJECTIVES: Cleft lip and/or palate (CL/P) is the most common craniofacial congenital disease, and it has a complex aetiology. This study aimed to identify the causative gene mutation of a Han Chinese family with CL/P. SUBJECTS AND METHODS: Whole exome sequencing was conducted on the proband and her mother, who exhibited the same phenotype. A Mendelian dominant inheritance model, allele frequency, mutation regions, functional prediction and literature review were used to screen and filter the variants...
June 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29908063/oligonucleotide-therapy-mitigates-disease-in-spinocerebellar-ataxia-type-3-mice
#18
Hayley S McLoughlin, Lauren R Moore, Ravi Chopra, Robert Komlo, Megan McKenzie, Kate G Blumenstein, Hien Zhao, Holly B Kordasiewicz, Vikram G Shakkottai, Henry L Paulson
OBJECTIVE: Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common dominantly inherited ataxia. Despite advances in understanding this CAG repeat/polyglutamine expansion disease, there are still no therapies to alter its progressive fatal course. Here we investigate whether an antisense oligonucleotide (ASO) targeting the SCA3 disease gene, ATXN3, can prevent molecular, neuropathological, electrophysiological and behavioral features of the disease in a mouse model of SCA3...
June 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29908051/use-of-colorectal-cancer-screening-tests-by-state
#19
Djenaba A Joseph, Jessica B King, Thomas B Richards, Cheryll C Thomas, Lisa C Richardson
No abstract text is available yet for this article.
June 14, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29908050/australian-community-pharmacists-experience-of-implementing-a-chronic-kidney-disease-risk-assessment-service
#20
Pankti A Gheewala, Gregory M Peterson, Syed Tabish R Zaidi, Matthew D Jose, Ronald L Castelino
INTRODUCTION: Community pharmacists are well positioned to deliver chronic kidney disease (CKD) screening services. However, little is known about the challenges faced by pharmacists during service implementation. This study aimed to explore community pharmacists' experiences and perceived barriers of implementing a CKD risk assessment service. METHODS: Data collection was performed by using semistructured, open-ended interview questions. Pharmacists who had implemented a CKD screening service in Tasmania, Australia, were eligible to participate...
June 14, 2018: Preventing Chronic Disease
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