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Trans cinnamaldehyde

P Suwanamornlert, S Sangchote, W Chinsirikul, A Sane, V Chonhenchob
The aim of this study was to find alternatives to conventional synthetic fungicides to control postharvest decay of longan fruit. The antifungal potential of thymol, carvacrol and trans-cinnamaldehyde was evaluated against four major longan pathogens, Lasiodiplodia spp., Phomopsis spp., Pestalotiopsis spp. and Geotrichum candidum, using vapor phase and direct contact methods. The vapor phase of all active compounds was more effective on fungal growth than direct contact. A volatile vapor of thymol and carvacrol had strong antifungal activity against the tested fungi, exhibiting minimum inhibitory concentration (MIC) in the range of 40 to 80 mg/L air; trans-cinnamaldehyde showed the least efficiency, with MIC ranging from 80 to 160 mg/L air for G...
February 10, 2018: International Journal of Food Microbiology
Shiowshuh Sheen, Chi-Yun Huang, Rommel Ramos, Shih-Yung Chien, O Joseph Scullen, Christopher Sommers
Pathogenic Escherichia coli, intestinal (O157:H7) as well as extraintestinal types (for example, Uropathogenic E. coli [UPEC]) are commonly found in many foods including raw chicken meat. The resistance of E. coli O157:H7 to UPEC in chicken meat under the stresses of high hydrostatic Pressure (HHP, also known as HPP-high pressure processing) and trans-cinnamaldehyde (an essential oil) was investigated and compared. UPEC was found slightly less resistant than O157:H7 in our test parameter ranges. With the addition of trans-cinnamaldehyde as an antimicrobial to meat, HPP lethality enhanced both O157:H7 and UPEC inactivation...
February 7, 2018: Journal of Food Science
Mi Eun Kim, Ju Yong Na, Jun Sik Lee
OBJECTIVES: Inflammation is a primary response of the innate immune system against various infections. Macrophages are a type of immune cell that have a critical role in the inflammation. Recent studies reported that various natural compounds could regulate immune responses such as inflammation. Trans-cinnamaldehyde (TCA) is a natural compound from cinnamon, especially abundant in cinnamon bark. Previous studies reported that TCA has anti-biofilm, anti-microbial, and anti-cancer activities...
January 22, 2018: Immunopharmacology and Immunotoxicology
Yan Fu, Pin Yang, Yang Zhao, Liqing Zhang, Zhangang Zhang, Xianwen Dong, Zhongping Wu, Ying Xu, Yongjun Chen
Background: Microglial activation contributes to neuroinflammation and neuronal damage in neurodegenerative disorders including Alzheimer's and Parkinson's diseases. It has been suggested that neurodegenerative disorders may be improved if neuroinflammation can be controlled. trans -cinnamaldehyde (TCA) isolated from the stem bark of Cinnamomum cassia possesses potent anti-inflammatory capability; we thus tested whether TCA presents neuroprotective effects on improving neuronal survival by inhibiting neuroinflammatory responses in BV2 microglial cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Des Field, Inès Baghou, Mary C Rea, Gillian E Gardiner, R Paul Ross, Colin Hill
Post-weaning diarrhoea (PWD) due to enterotoxigenic Escherichia coli (ETEC) is an economically important disease in pig production worldwide. Although antibiotics have contributed significantly to mitigate the economic losses caused by PWD, there is major concern over the increased incidence of antimicrobial resistance among bacteria isolated from pigs. Consequently, suitable alternatives that are safe and effective are urgently required. Many naturally occurring compounds, including the antimicrobial peptide nisin and a number of plant essential oils, have been widely studied and are reported to be effective as antimicrobial agents against pathogenic microorganisms...
December 12, 2017: Antibiotics
Manuela Gottardi, Peter Grün, Helge B Bode, Thomas Hoffmann, Wilfried Schwab, Mislav Oreb, Eckhard Boles
Trans-cinnamic acid (tCA) and hydrocinnamyl alcohol (HcinOH) are valuable aromatic compounds with applications in the flavour, fragrance and cosmetic industry. They can be produced with recombinant yeasts from sugars via phenylalanine after expression of a phenylalanine ammonia lyase (PAL) and an aryl carboxylic acid reductase. Here, we show that in Saccharomyces cerevisiae a PAL enzyme from the bacterium Photorhabdus luminescens was superior to a previously used plant PAL enzyme for the production of tCA. Moreover, after expression of a UDP-glucose:cinnamate glucosyltransferase (FaGT2) from Fragaria x ananassa, tCA could be converted to cinnamoyl-D-glucose which is expected to be less toxic to the yeast cells...
December 1, 2017: FEMS Yeast Research
Anup Kollanoor Johny, Jonathan G Frye, Annie Donoghue, Dan J Donoghue, Steffen Porwollik, Michael McClelland, Kumar Venkitanarayanan
Background:Salmonella Enteritidis phage type 8 (PT8) is a major poultry-associated Salmonella strain implicated in foodborne outbreaks in the United States. We previously reported that two plant-derived compounds generally recognized as safe (GRAS), trans-cinnamaldehyde (TC), and eugenol (EG), significantly reduced S. Enteritidis colonization in broiler and layer chickens. To elucidate potential PT8 genes affected by TC and EG during colonization, a whole-genome microarray analysis of the bacterium treated with TC and EG was conducted...
2017: Frontiers in Microbiology
Hayriye Cetin-Karaca, Melissa C Newman
The objective of this study was to determine the potential use of Trans-cinnamaldehyde (TC), (-)-Epigallocatechin gallate (EGCG) and [10]-Gingerol (GI) to inhibit the growth of B. cereus in infant rice cereal reconstituted with infant formula. Samples were inoculated with either vegetative cells or spores of B. cereus (ATCC 14579), and they were treated with 500 ppm (mg/L) TC, EGCG and GI. They were stored at 7 °C, 23 °C, or 37 °C for 0, 4, 8 and 24 h to simulate advance preparation, handling and temperature abuse...
February 2018: Food Microbiology
Hsin-Bai Yin, Chi-Hung Chen, Michael J Darre, Ann M Donoghue, Dan J Donoghue, Kumar Venkitanarayanan
Aflatoxins (AF) are toxic metabolites produced by molds, Aspergillus flavus and Aspergillus parasiticus, which frequently contaminate poultry feed ingredients. Ingestion of AF-contaminated feed by chickens leads to deleterious effects, including decreased bird performance and reduced egg production. Moreover, AF residues in fertilized eggs result in huge economic losses by decreasing embryo viability and hatchability. This study investigated the efficacy of 2 generally recognized as safe phytochemicals, namely carvacrol (CR) and trans-cinnamaldehyde (TC), in protecting chicken embryos from AF-induced toxicity...
October 1, 2017: Poultry Science
Erickson M Paragas, Sara C Humphreys, Joshua Min, Carolyn A Joswig-Jones, Silke Leimkühler, Jeffrey P Jones
Although aldehyde oxidase (AO) is an important hepatic drug-metabolizing enzyme, it remains understudied and is consequently often overlooked in preclinical studies, an oversight that has resulted in the failure of multiple clinical trials. AO's preclusion to investigation stems from the following: (1) difficulties synthesizing metabolic standards due to the chemospecificity and regiospecificity of the enzyme and (2) significant inherent variability across existing in vitro systems including liver cytosol, S9 fractions, and primary hepatocytes, which lack specificity and generate discordant expression and activity profiles...
August 31, 2017: ACS Omega
Reyhaneh Sohrabi, Nasim Pazgoohan, Hasan Rezaei Seresht, Bahareh Amin
OBJECTIVES: The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. MATERIALS AND METHODS: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0.5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0...
June 2017: Iranian Journal of Basic Medical Sciences
Shunxi Dong, Marcus Frings, Duo Zhang, Qianqian Guo, Constantin G Daniliuc, Hanchao Cheng, Carsten Bolm
An N-heterocyclic carbene (NHC)-catalyzed highly diastereo- and enantioselective formal [3+2] reaction of o-hydroxy aromatic aldimines and cinnamaldehydes for the preparation of enantioenriched trans-γ-lactams was developed. An internal hydrogen bond between the o-hydroxy and the imine function was crucial for the reactivity and chemical selectivity. Trans-γ-lactam 3 d was easily oxidized to multifunctional 1,4-benzoquinone 8, which could further be transformed to biaryl 9 in the presence of a phosphoric acid...
August 22, 2017: Chemistry: a European Journal
Young-Sil Lee, Eunjung Son, Seung-Hyung Kim, Yun Mi Lee, Ohn Soon Kim, Dong-Seon Kim
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
Barbara Kot, Kamila Wierzchowska, Agata Grużewska, Dzmitry Lohinau
The aim of this study was to evaluate the ability of 0.1% thyme oil (TO), trans-cinnamaldehyde (TC), ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), lavender essential oil (LO), geranium essential oil (GO) and tee tree oil (TTO) to control biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) strains. Depending on the strains, TO reduced 59.7-85% of biofilm mass, while TC 52.9-82.4% after 48 h of treatment. Reduction of metabolic activity of biofilms in ranges 79.3-86% and 85...
June 18, 2017: Natural Product Research
Shalisa M Oburn, Dale C Swenson, S V Santhana Mariappan, Leonard R MacGillivray
A combination of metal-organic self-assembly and reversible imine formation is used to achieve an organic synthesis via the solid state. Imine bond formation is employed to install a pyridyl to the alkene trans-cinnamaldehyde while Ag(I) ions are used in a second step to assemble the pyridyl-functionalized alkene into a geometry in the solid state for an intermolecular [2 + 2] photodimerization. The alkene undergoes the cycloaddition reaction via a 1D coordination polymer to generate a pyridyl-functionalized cyclobutane stereoselectively and in quantitative yield...
June 15, 2017: Journal of the American Chemical Society
N Roshan, T V Riley, K A Hammer
AIMS: To investigate the antimicrobial activity of various natural products against Clostridium difficile in vitro. METHODS AND RESULTS: The antibacterial activity of 20 natural products was determined by the agar well diffusion and broth microdilution assays against four C. difficile strains, three comparator organisms and four gastrointestinal commensal organisms. Of the raw natural products, garlic juice had the highest activity. The most active processed products were peppermint oil and the four pure compounds trans-cinnamaldehyde, allicin, menthol and zingerone...
May 10, 2017: Journal of Applied Microbiology
Abhinav Upadhyay, Komala Arsi, Basanta R Wagle, Indu Upadhyaya, Sandip Shrestha, Ann M Donoghue, Dan J Donoghue
Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal distending toxin mediated cell death, and enteritis. Reducing the attachment and invasion of Campylobacter to intestinal epithelium and expression of its virulence factors such as motility and cytolethal distending toxin (CDT) production could potentially reduce infection in humans...
2017: Frontiers in Microbiology
Enis Nadia Md Yusof, Mohamed I M Tahir, Thahira B S A Ravoof, Sang Loon Tan, Edward R T Tiekink
The title di-thio-carbazate ester (I), C18H18N2S2 [systematic name: (E)-4-methyl-benzyl 2-[(E)-3-phenyl-allyl-idene]hydrazinecarbodi-thio-ate, comprises an almost planar central CN2S2 residue [r.m.s. deviation = 0.0131 Å]. The methyl-ene(tolyl-4) group forms a dihedral angle of 72.25 (4)° with the best plane through the remaining non-hydrogen atoms [r.m.s. deviation = 0.0586 Å] so the mol-ecule approximates mirror symmetry with the 4-tolyl group bis-ected by the plane. The configuration about both double bonds in the N-N=C-C=C chain is E; the chain has an all trans conformation...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John
ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum verum (CV), also known as 'Dalchini', is the dry bark of the Cinnamomum verum (L.) plant, and has been used as a traditional Pakistani medicine to alleviate pain and inflammation in patients suffering from arthritic rheumatism. It contains alkaloids, triterpenes, Cinnamaldehyde and other volatile oils. The aim of the present study was to investigate the underlying biological effect of ethyl alcohol (EtOH) and methyl alcohol (MeOH) extracts from CV on collagen type-II induced arthritic (CIA) mice...
April 20, 2017: Inflammopharmacology
Alicia Campion, Ruth Morrissey, Des Field, Paul D Cotter, Colin Hill, R Paul Ross
Cronobacter sakazakii and Escherichia coli O157:H7 are well known food-borne pathogens that can cause severe disease. The identification of new alternatives to heating to control these pathogens in foods, while reducing the impact on organoleptic properties and nutritional value, is highly desirable. In this study, nisin and its bioengineered variants, nisin V and nisin S29A, are used alone, or in combination with plant essential oils (thymol, carvacrol and trans-cinnamaldehyde) or citric acid, with a view to controlling C...
August 2017: Food Microbiology
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