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Trans cinnamaldehyde

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https://www.readbyqxmd.com/read/29018419/gene-expression-response-of-salmonella-enterica-serotype-enteritidis-phage-type-8-to-subinhibitory-concentrations-of-the-plant-derived-compounds-trans-cinnamaldehyde-and-eugenol
#1
Anup Kollanoor Johny, Jonathan G Frye, Annie Donoghue, Dan J Donoghue, Steffen Porwollik, Michael McClelland, Kumar Venkitanarayanan
Background:Salmonella Enteritidis phage type 8 (PT8) is a major poultry-associated Salmonella strain implicated in foodborne outbreaks in the United States. We previously reported that two plant-derived compounds generally recognized as safe (GRAS), trans-cinnamaldehyde (TC), and eugenol (EG), significantly reduced S. Enteritidis colonization in broiler and layer chickens. To elucidate potential PT8 genes affected by TC and EG during colonization, a whole-genome microarray analysis of the bacterium treated with TC and EG was conducted...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28941901/antimicrobial-efficacy-of-phytochemicals-against-bacillus-cereus-in-reconstituted-infant-rice-cereal
#2
Hayriye Cetin-Karaca, Melissa C Newman
The objective of this study was to determine the potential use of Trans-cinnamaldehyde (TC), (-)-Epigallocatechin gallate (EGCG) and [10]-Gingerol (GI) to inhibit the growth of B. cereus in infant rice cereal reconstituted with infant formula. Samples were inoculated with either vegetative cells or spores of B. cereus (ATCC 14579), and they were treated with 500 ppm (mg/L) TC, EGCG and GI. They were stored at 7 °C, 23 °C, or 37 °C for 0, 4, 8 and 24 h to simulate advance preparation, handling and temperature abuse...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28938783/phytochemicals-reduce-aflatoxin-induced-toxicity-in-chicken-embryos
#3
Hsin-Bai Yin, Chi-Hung Chen, Michael J Darre, Ann M Donoghue, Dan J Donoghue, Kumar Venkitanarayanan
Aflatoxins (AF) are toxic metabolites produced by molds, Aspergillus flavus and Aspergillus parasiticus, which frequently contaminate poultry feed ingredients. Ingestion of AF-contaminated feed by chickens leads to deleterious effects, including decreased bird performance and reduced egg production. Moreover, AF residues in fertilized eggs result in huge economic losses by decreasing embryo viability and hatchability. This study investigated the efficacy of 2 generally recognized as safe phytochemicals, namely carvacrol (CR) and trans-cinnamaldehyde (TC), in protecting chicken embryos from AF-induced toxicity...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28884164/ecoao-a-simple-system-for-the-study-of-human-aldehyde-oxidases-role-in-drug-metabolism
#4
Erickson M Paragas, Sara C Humphreys, Joshua Min, Carolyn A Joswig-Jones, Silke Leimkühler, Jeffrey P Jones
Although aldehyde oxidase (AO) is an important hepatic drug-metabolizing enzyme, it remains understudied and is consequently often overlooked in preclinical studies, an oversight that has resulted in the failure of multiple clinical trials. AO's preclusion to investigation stems from the following: (1) difficulties synthesizing metabolic standards due to the chemospecificity and regiospecificity of the enzyme and (2) significant inherent variability across existing in vitro systems including liver cytosol, S9 fractions, and primary hepatocytes, which lack specificity and generate discordant expression and activity profiles...
August 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28868126/repeated-systemic-administration-of-the-cinnamon-essential-oil-possesses-anti-anxiety-and-anti-depressant-activities-in-mice
#5
Reyhaneh Sohrabi, Nasim Pazgoohan, Hasan Rezaei Seresht, Bahareh Amin
OBJECTIVES: The present study aimed to evaluate the putative antidepressant and anti-anxiety effects of the cinnamon essential oil when administered acute (for 3 doses) and sub-acute (for 14 days) to mice. MATERIALS AND METHODS: In an acute experimental study, forced swim test (FST) was conducted to evaluate the antidepressant-like behavior of animals treated with the intraperitoneal (IP) essential oil of cinnamon in triple doses (0.5, 1, and 2 mg/kg). In a sub-acute study (14 days in 24-hr intervals) antidepressant-like effects of essential oil (0...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28833642/organocatalytic-asymmetric-synthesis-of-trans-%C3%AE-lactams
#6
Shunxi Dong, Marcus Frings, Duo Zhang, Qianqian Guo, Constantin G Daniliuc, Hanchao Cheng, Carsten Bolm
An N-heterocyclic carbene (NHC)-catalyzed highly diastereo- and enantioselective formal [3+2] reaction of o-hydroxy aromatic aldimines and cinnamaldehydes for the preparation of enantioenriched trans-γ-lactams was developed. An internal hydrogen bond between the o-hydroxy and the imine function was crucial for the reactivity and chemical selectivity. Trans-γ-lactam 3 d was easily oxidized to multifunctional 1,4-benzoquinone 8, which could further be transformed to biaryl 9 in the presence of a phosphoric acid...
August 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28769989/synergistic-uric-acid-lowering-effects-of-the-combination-of-chrysanthemum-indicum-linne-flower-and-cinnamomum-cassia-l-j-persl-bark-extracts
#7
Young-Sil Lee, Eunjung Son, Seung-Hyung Kim, Yun Mi Lee, Ohn Soon Kim, Dong-Seon Kim
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Persl bark (CB) extracts have served as the main ingredients in several prescriptions designed to treat hyperuricemia and gout in traditional Chinese and Korean medicine. However, little is known about the combination effects of a CF and CB (CC) mixture on hyperuricemia. In our study, we investigated the antihyperuricemic effects of CC mixture and the mechanisms underlying these effects in normal and potassium oxonate- (PO-) induced hyperuricemic rats...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28627304/the-effects-of-selected-phytochemicals-on-biofilm-formed-by-five-methicillin-resistant-staphylococcus-aureus
#8
Barbara Kot, Kamila Wierzchowska, Agata Grużewska, Dzmitry Lohinau
The aim of this study was to evaluate the ability of 0.1% thyme oil (TO), trans-cinnamaldehyde (TC), ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), lavender essential oil (LO), geranium essential oil (GO) and tee tree oil (TTO) to control biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) strains. Depending on the strains, TO reduced 59.7-85% of biofilm mass, while TC 52.9-82.4% after 48 h of treatment. Reduction of metabolic activity of biofilms in ranges 79.3-86% and 85...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28605202/supramolecular-construction-of-an-aldehyde-cyclobutane-via-the-solid-state-combining-reversible-imine-formation-and-metal-organic-self-assembly
#9
Shalisa M Oburn, Dale C Swenson, S V Santhana Mariappan, Leonard R MacGillivray
A combination of metal-organic self-assembly and reversible imine formation is used to achieve an organic synthesis via the solid state. Imine bond formation is employed to install a pyridyl to the alkene trans-cinnamaldehyde while Ag(I) ions are used in a second step to assemble the pyridyl-functionalized alkene into a geometry in the solid state for an intermolecular [2 + 2] photodimerization. The alkene undergoes the cycloaddition reaction via a 1D coordination polymer to generate a pyridyl-functionalized cyclobutane stereoselectively and in quantitative yield...
June 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28489336/antimicrobial-activity-of-natural-products-against-clostridium-difficile-in%C3%A2-vitro
#10
N Roshan, T V Riley, K A Hammer
AIMS: To investigate the antimicrobial activity of various natural products against Clostridium difficile in vitro. METHODS AND RESULTS: The antibacterial activity of 20 natural products was determined by the agar well diffusion and broth microdilution assays against four C. difficile strains, three comparator organisms and four gastrointestinal commensal organisms. Of the raw natural products, garlic juice had the highest activity. The most active processed products were peppermint oil and the four pure compounds trans-cinnamaldehyde, allicin, menthol and zingerone...
May 10, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28487683/trans-cinnamaldehyde-carvacrol-and-eugenol-reduce-campylobacter-jejuni-colonization-factors-and-expression-of-virulence-genes-in-vitro
#11
Abhinav Upadhyay, Komala Arsi, Basanta R Wagle, Indu Upadhyaya, Sandip Shrestha, Ann M Donoghue, Dan J Donoghue
Campylobacter jejuni is a major foodborne pathogen that causes severe gastroenteritis in humans characterized by fever, diarrhea, and abdominal cramps. In the human gut, Campylobacter adheres and invades the intestinal epithelium followed by cytolethal distending toxin mediated cell death, and enteritis. Reducing the attachment and invasion of Campylobacter to intestinal epithelium and expression of its virulence factors such as motility and cytolethal distending toxin (CDT) production could potentially reduce infection in humans...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28435717/a-cinnamaldehyde-schiff-base-of-s-4-methyl-benz-yl-di-thio-carbazate-crystal-structure-hirshfeld-surface-analysis-and-computational-study
#12
Enis Nadia Md Yusof, Mohamed I M Tahir, Thahira B S A Ravoof, Sang Loon Tan, Edward R T Tiekink
The title di-thio-carbazate ester (I), C18H18N2S2 [systematic name: (E)-4-methyl-benzyl 2-[(E)-3-phenyl-allyl-idene]hydrazinecarbodi-thio-ate, comprises an almost planar central CN2S2 residue [r.m.s. deviation = 0.0131 Å]. The methyl-ene(tolyl-4) group forms a dihedral angle of 72.25 (4)° with the best plane through the remaining non-hydrogen atoms [r.m.s. deviation = 0.0586 Å] so the mol-ecule approximates mirror symmetry with the 4-tolyl group bis-ected by the plane. The configuration about both double bonds in the N-N=C-C=C chain is E; the chain has an all trans conformation...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28429097/immunomodulatory-and-therapeutic-role-of-cinnamomum-verum-extracts-in-collagen-induced-arthritic-balb-c-mice
#13
Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John
ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum verum (CV), also known as 'Dalchini', is the dry bark of the Cinnamomum verum (L.) plant, and has been used as a traditional Pakistani medicine to alleviate pain and inflammation in patients suffering from arthritic rheumatism. It contains alkaloids, triterpenes, Cinnamaldehyde and other volatile oils. The aim of the present study was to investigate the underlying biological effect of ethyl alcohol (EtOH) and methyl alcohol (MeOH) extracts from CV on collagen type-II induced arthritic (CIA) mice...
April 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28400011/use-of-enhanced-nisin-derivatives-in-combination-with-food-grade-oils-or-citric-acid-to-control-cronobacter-sakazakii-and-escherichia-coli-o157-h7
#14
Alicia Campion, Ruth Morrissey, Des Field, Paul D Cotter, Colin Hill, R Paul Ross
Cronobacter sakazakii and Escherichia coli O157:H7 are well known food-borne pathogens that can cause severe disease. The identification of new alternatives to heating to control these pathogens in foods, while reducing the impact on organoleptic properties and nutritional value, is highly desirable. In this study, nisin and its bioengineered variants, nisin V and nisin S29A, are used alone, or in combination with plant essential oils (thymol, carvacrol and trans-cinnamaldehyde) or citric acid, with a view to controlling C...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28353001/de-novo-biosynthesis-of-trans-cinnamic-acid-derivatives-in-saccharomyces-cerevisiae
#15
Manuela Gottardi, Jan Dines Knudsen, Lydie Prado, Mislav Oreb, Paola Branduardi, Eckhard Boles
The production of natural aroma compounds is an expanding field within the branch of white biotechnology. Three aromatic compounds of interest are cinnamaldehyde, the typical cinnamon aroma that has applications in agriculture and medical sciences, as well as cinnamyl alcohol and hydrocinnamyl alcohol, which have applications in the cosmetic industry. Current production methods, which rely on extraction from plant materials or chemical synthesis, are associated with drawbacks regarding scalability, production time, and environmental impact...
March 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28342836/membrane-fatty-acid-composition-as-a-determinant-of-listeria-monocytogenes-sensitivity-to-trans-cinnamaldehyde
#16
Gil Rogiers, Biniam T Kebede, Ann Van Loey, Chris W Michiels
trans-Cinnamaldehyde, the major compound of cinnamon essential oil, is a potentially interesting natural antimicrobial food preservative. Although a number of studies have addressed its mode of action, the factors that determine bacterial sensitivity or tolerance to trans-cinnamaldehyde are poorly understood. We report the detailed characterization of a Listeria monocytogenes Scott A trans-cinnamaldehyde hypersensitive mutant defective in IlvE, which catalyzes the reversible transamination of branched-chain amino acids to the corresponding short-chain α-ketoacids...
March 23, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28334192/insecticidal-properties-of-essential-oils-and-some-of-their-constituents-on-the-turkestan-cockroach-blattodea-blattidae
#17
Sudip Gaire, Mary O'Connell, Francisco O Holguin, Anup Amatya, Scott Bundy, Alvaro Romero
The Turkestan cockroach, Blatta lateralis (Walker), has become the most important peridomestic species in urban areas of the Southwestern United States. The aim of this study was to evaluate the use of botanical compounds to control this urban pest. We tested the acute toxicity and repellency of six botanical constituents and three essential oils on Turkestan cockroach nymphs. Chemical composition of the essential oils was also determined. Topical and fumigant assays with nymphs showed that thymol was the most toxic essential oil constituent, with a LD50 of 0...
April 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28221905/efficacy-of-plant-derived-antimicrobials-in-controlling-enterohemorrhagic-escherichia-coli-virulence-in-vitro
#18
Sangeetha Ananda Baskaran, Anup Kollanoor-Johny, Meera Surendran Nair, Kumar Venkitanarayanan
Escherichia coli O157:H7 is a major foodborne pathogen that can cause serious human illness characterized by hemorrhagic diarrhea and kidney failure. The pathology of enterohemorrhagic E. coli O157:H7 (EHEC) infection is primarily mediated by verotoxins, which bind to the globotriaosylceramide receptor on host cells. Antibiotics are contraindicated for treating EHEC infection because they lead to increased verotoxin release, thereby increasing the risk of renal failure and death in patients. Thus, alternative strategies are needed for controlling EHEC infections in humans...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28129937/determination-of-cinnamaldehyde-carvacrol-and-thymol-in-feedstuff-additives-by-pressurized-liquid-extraction-followed-by-gas-chromatography-mass-spectrometry
#19
Marta Jiménez-Salcedo, María Teresa Tena
Specific blends of essential oils (BEOs) are promising substitutes for antibiotics to promote livestock performance and to reduce the incidence of intestinal disorders. Microencapsulation of BEOs has shown to improve their stability, bioavailability and to control their release rate once they are added to the feedstuff. The development and validation of a method for determining essential oil components such as carvacrol, thymol and cinnamaldehyde in a microencapsulated material used as feed additive is presented...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28075116/metal-organic-frameworks-for-thin-layer-chromatographic-applications
#20
Claudia Schenk, Christel Kutzscher, Franziska Drache, Stella Helten, Irena Senkovska, Stefan Kaskel
Preparation of thin-layer chromatographic (TLC) plates based on metal-organic frameworks (MOFs) as porous stationary phases is described. DUT-67 (DUT = Dresden University of Technology), a zirconium based MOF, was used in combination with a fluorescent indicator as stationary phase for analyzing a small selection of a wide spectrum of relevant analytes. The successful separation of benzaldehyde from trans-cinnamaldehyde and 4-aminophenol from 2-aminotoluene is reported as a model system using optimized eluent mixtures containing acetic acid...
January 11, 2017: ACS Applied Materials & Interfaces
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