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Carvacrol

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https://www.readbyqxmd.com/read/27905512/plant-phenolic-volatiles-inhibit-quorum-sensing-in-pectobacteria-and-reduce-their-virulence-by-potential-binding-to-expi-and-expr-proteins
#1
Janak Raj Joshi, Netaly Khazanov, Hanoch Senderowitz, Saul Burdman, Alexander Lipsky, Iris Yedidia
Quorum sensing (QS) is a population density-dependent regulatory system in bacteria that couples gene expression to cell density through accumulation of diffusible signaling molecules. Pectobacteria are causal agents of soft rot disease in a range of economically important crops. They rely on QS to coordinate their main virulence factor, production of plant cell wall degrading enzymes (PCWDEs). Plants have evolved an array of antimicrobial compounds to anticipate and cope with pathogens, of which essential oils (EOs) are widely recognized...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884791/immunomodulatory-effect-of-characterized-extract-of-zataria-multiflora-on-th1-th2-and-th17-in-normal-and-th2-polarization-state
#2
Majid Kianmehr, Abdolrahim Rezaei, Mahmoud Hosseini, Mohammad Reza Khazdair, Ramin Rezaee, Vahid Reza Askari, Mohammad Hossein Boskabady
The effect of the extract of Zataria multiflora (Z. multiflora) on IFN-γ, FOXP3, IL-4, TGF-β, and IL-17 gene expression was evaluated in cultured splenocytes obtained from control, nontreated asthma or sensitized mice (group S), Sensetized animals treated with dexamethasone or three concentrations of Z. multiflora extract (200, 400 and 800 μg/ml) (n = 6, for each group). IFN-γ and FOXP3 gene expressions were significantly decreased (P < 0.001 for both cases) but IL-4 (P < 0.001) and IL-17 (P < 0...
November 21, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27878214/lethal-and-sublethal-effects-of-essential-oil-of-lippia-sidoides-verbenaceae-and-monoterpenes-on-chagas-disease-vector-rhodnius-prolixus
#3
Marcela B Figueiredo, Geovany A Gomes, Jayme M Santangelo, Emerson G Pontes, Patricia Azambuja, Elói S Garcia, Mário G de Carvalho
The aim of this study was to identify the composition of the essential oil from leaves of Lippia sidoides (EOLS), a typical shrub commonly found in the dry northeast of Brazil, popularly known as "alecrim-pimenta". Additionally, we investigated the nymphicidal, ovicidal, phagoinhibitory and excretion effects of EOLS, its major constituent thymol and its isomer carvacrol, on fourth instar nymphs and eggs of Rhodnius prolixus, the Chagas' disease vector. The nymphicidal and ovicidal activity of thymol, carvacrol, and EOLS was assessed by tests using impregnated Petri dishes...
November 21, 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27872717/the-antibacterial-effect-of-ziziphora-clinopodioides-essential-oil-and-nisinagainst-salmonella-typhimurium-and-staphylococcus-aureus-in-doogh-a-yoghurt-based-iranian-drink
#4
Yasser Shahbazi
Doogh is the most popular and commonly consumed yoghurt-based Iranian drink. The aim of this study was to investigate the antibacterial effects of Ziziphora clinopodioides essential oil (ZEO) at 0.10 and 0.20% concentrations, nisin at 250 and 500 IU mL(-1), and their combination against Salmonella typhimurium and Staphylococcusaureus in doogh during storage at 4 ˚C for  9 days. Nine batches were studied as follows: control: no ZEO or nisin added, A: 0.10% ZEO, B: 0.20% ZEO, C: 250 IU mL(-1) nisin, D: 500 IU mL(-1) nisin, E: 0...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27866466/preventive-effect-of-carvacrol-against-oxidative-damage-in-aged-rat-liver
#5
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
The present study was designed to investigate the changes in activities of antioxidant enzymes and lipid peroxidation level in the liver of 2, 10 and 20 months old rats, and to see whether these changes are restored to those of the two month old rats after carvacrol treatment. Male rats of 2, 10, and 20 months (n = 10 for each group) were used for all the experiments. The aged rats (10 and 20 months old) were given carvacrol (15 mg/day per body weight) for 30 days. Control animals received an equal volume of vehicle...
November 21, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/27865956/safranal-and-its-analogs-inhibit-escherichia-coli-atp-synthase-and-cell-growth
#6
Mason Liu, Amon Amini, Zulfiqar Ahmad
Safranal, a dominant component of saffron, is known to have antitumor, cytotoxic, and antibacterial properties. In this study, we examined safranal and its structural analogs-thymol, carvacrol, damascenone, cuminol, 2,6,6-trimethyl-2-cyclohexene-1,4-dione (TMCHD), 4-isopropylbenzyl bromide (IPBB), and 4-tert-butylphenol (TBP) induced inhibition of Escherichia coli membrane bound F1Fo ATP synthase. Safranal and its analogs inhibited wild-type enzyme to variable degrees. While safranal caused 100% inhibition of wild-type F1Fo ATP synthase, only about 50% inhibition occurred for αR283D mutant ATP synthase...
November 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27855883/essential-oil-composition-total-phenolic-flavonoid-contents-and-antioxidant-activity-of-thymus-species-collected-from-different-regions-of-iran
#7
Behnaz Tohidi, Mehdi Rahimmalek, Ahmad Arzani
In this study, the essential oil (EO) composition, flavonoid and phenolic contents, and antioxidant activities of fourteen Thymus accessions belonging to ten species were evaluated. Gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of 38 compounds with the major constituents including thymol (12.4-79.74%), carvacrol (4.37-42.14%), geraniol (0.3-22.44%), and p-cymene (0.8-12.86%). Cluster analysis identified three groups of high thymol, geraniol/linalool, and high carvacrol. The highest phenolic and flavonoid contents were detected in T...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27848145/monoterpene-esters-and-aporphine-alkaloids-from-illigera-aromatica-with-inhibitory-effects-against-cholinesterase-and-no-production-in-lps-stimulated-raw264-7-macrophages
#8
Jian-Wei Dong, Le Cai, Xue-Jiao Li, Jia-Peng Wang, Rui-Feng Mei, Zhong-Tao Ding
Three new monoterpene phenylpropionic acid esters, illigerates A-C (1-3), and one new aporphine alkaloid, illigeranine (4), as well as four known ones, actinodaphnine (5), nordicentrine (6), 8-hydroxy carvacrol (7), and 3-hydroxy-α,4-dimethyl styrene (8), were isolated from the tubers of Illigera aromatica. The structures of 1-4 were identified by HRESIMS, 1D and 2D NMR, and electronic circular dichroism spectra. Compound 1 potently inhibited NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 18...
November 15, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27834831/synthesis-and-in-vitro-anti-leishmania-amazonensis-biological-screening-of-morita-baylis-hillman-adducts-prepared-from-eugenol-thymol-and-carvacrol
#9
Francisco José Seixas Xavier, Klinger Antonio da Franca Rodrigues, Ramon Guerra de Oliveira, Claudio Gabriel Lima Junior, Juliana da Câmara Rocha, Tatjana Souza Lima Keesen, Marcia Rosa de Oliveira, Fábio Pedrosa Lins Silva, Mário Luiz Araújo de Almeida Vasconcellos
Leishmaniasis represents a series of severe neglected tropical diseases caused by protozoa of the genus Leishmania and is widely distributed around the world. Here, we present the syntheses of Morita-Baylis-Hillman adducts (MBHAs) prepared from eugenol, thymol and carvacrol, and their bioevaluation against promastigotes of Leishmania amazonensis. The new MBHAs are prepared in two steps from essential oils in moderate to good yields and present IC50 values in the range of 22.30-4.71 μM. Moreover, the selectivity index to the most potent compound is very high (SIrb > 84...
November 8, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27829163/genotoxicity-evaluation-of-carvacrol-in-rats-using-a-combined-micronucleus-and-comet-assay
#10
María Llana-Ruiz-Cabello, Sara Maisanaba, María Puerto, Ana I Prieto, Silvia Pichardo, Rosario Moyano, José A González-Pérez, Ana M Cameán
Genotoxic data of substances which could be incorporated into food packaging are required by the European Food Safety Authority. Due to its antioxidant and antibacterial properties carvacrol is one of these compounds. This work aims to study for the first time the in vivo genotoxic effects produced in rats orally exposed to 81, 256 or 810 mg cavacrol/kg body weight (bw) at 0, 24 and 45 h. A combination of the micronucleus assay (OECD 474) in bone marrow and the standard (OECD 489) and enzyme-modified comet assay was used to determine the genotoxicity on cells isolated from stomach and liver of exposed animals...
November 6, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27825756/carvacrol-attenuates-acute-kidney-injury-induced-by-cisplatin-through-suppression-of-erk-and-pi3k-akt-activation
#11
Iva Potočnjak, Robert Domitrović
We investigated the mechanisms of renoprotective effects of carvacrol, a monoterpenoid compound, against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 1, 3, and 10 mg carvacrol/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, renal oxidative stress was evidenced by increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), cytochrome P450 E1 (CYP2E1), and heme oxygenase-1 (HO-1). CP treatment increased the expression of phosphorylated nuclear factor-kappaB (p-NF-κB) p65 and tumor necrosis factor-alpha (TNF-α) in kidneys, suggesting inflammatory response...
November 4, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27825701/differentiation-of-volatile-aromatic-isomers-and-structural-elucidation-of-volatile-compounds-in-essential-oils-by-combination-of-hplc-separation-and-crystalline-sponge-method
#12
Xiao-Fei Gu, Yue Zhao, Kan Li, Meng-Xiang Su, Fang Yan, Bo Li, Ying-Xiang Du, Bin Di
Structure elucidation of volatile aromatic isomers at trace level has long been considered as an elusive task, due to their structural similarities and similar polarities, even with the aid of many spectroscopic techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. Single-crystal X-ray diffraction (SCD) is recognized as one of the most powerful structural elucidation techniques. The recently developed crystalline sponge method overcomes the intrinsic limitation of SCD that the target molecules must be single crystals, being able to analyze non-crystalline and trace-amount compounds without any special treatment...
October 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27806651/essential-oil-composition-free-radical-scavenging-activity-and-polyphenolic-content-of-gaillonia-eriantha-jaub-spach-from-iran
#13
Atefeh Bahmanzadegan, Vahid Rowshan, Faraneh Zareiyan, Ahmad Hatami
Gaillonia eriantha is a member of family Paederieae (Rubiaceae). The essential oil of G. eriantha growing wild in south of Iran was obtained by hydrodistillation and analysed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). Antioxidante activity and polyphenolic content were identified by DPPH microplate method and HPLC-DAD, respectively. Twenty-two compounds were identified in the oil. The major volatile compounds were camphor (14.8%), octyl formate (14.7%), 1,8-cineole (10.9%), n-decane (8...
November 3, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27803760/carvacrol-alleviates-prostate-cancer-cell-proliferation-migration-and-invasion-through-regulation-of-pi3k-akt-and-mapk-signaling-pathways
#14
Yun Luo, Jie-Ying Wu, Min-Hua Lu, Zhi Shi, Ning Na, Jin-Ming Di
TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27793897/antioxidant-and-antiproliferative-properties-of-the-essential-oils-of-satureja-thymbra-and-satureja-parnassica-and-their-major-constituents
#15
Eleni Fitsiou, Ioannis Anestopoulos, Katerina Chlichlia, Alex Galanis, Ioannis Kourkoutas, Mihalis I Panayiotidis, Aglaia Pappa
AIM: The biopotential of the essential oils of the Greek aromatic plants Satureja thymbra and Satureja parnassica were investigated, together with their major components carvacrol, thymol, γ-terpinene and p-cymene. MATERIALS AND METHODS: Antioxidant and cancer cell cytotoxic properties were determined using 2,2-diphenyl-1-picrylhydrazyl and sulforhodamine B assays, respectively. The antiproliferative potential was studied against the MCF-7, A549, HepG2 and Hep3B cell lines...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27792456/antimicrobial-activity-and-chemical-composition-of-three-essential-oils-extracted-from-mediterranean-aromatic-plants
#16
Hazem S Elshafie, Shimaa Sakr, Stefania M Mang, Sandra Belviso, Vincenzo De Feo, Ippolito Camele
There is a growing interest in essential oils (EOs) as possible alternatives for traditional chemical pesticides. This study was carried out to characterize the chemical composition of the three EOs extracted from Verbena officinalis, Majorana hortensis, and Salvia officinalis using gas chromatography (GC) and GC-mass spectrometry (GC-MS) and to evaluate in vitro their efficacy against some phyto or human pathogens. The antifungal activity was investigated against Colletotrichum acutatum and Botrytis cinerea in comparison with Azoxystrobin as a large spectrum fungicide...
October 28, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27775634/structurally-related-monoterpenes-p-cymene-carvacrol-and-thymol-isolated-from-essential-oil-from-leaves-of-lippia-sidoides-cham-verbenaceae-protect-mice-against-elastase-induced-emphysema
#17
Ellen Games, Marina Guerreiro, Fernanda R Santana, Nathalia M Pinheiro, Emerson A de Oliveira, Fernanda D T Q S Lopes, Clarice R Olivo, Iolanda F L C Tibério, Mílton A Martins, João Henrique G Lago, Carla M Prado
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes (p-cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27765960/coleus-aromaticus-a-therapeutic-herb-with-multiple-potentials
#18
REVIEW
Dadasaheb D Wadikar, Prakash E Patki
The herb Coleus aromaticus belonging to Lamiaceae family and Coleus genus is known by numerous names in different parts of the world and several language specific vernacular names. The herb has been extensively studied as well as reported in several fields of science. The multiple potential of the herb includes allelopathic potential, antibacterial property, antimicrobial activity, insecticidal property; free radical scavenging and radio-protective components from herb extracts and most recently the appetizing potential of the herb have been reported...
July 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27723978/development-of-a-hs-spme-gc-ms-ms-method-for-the-quantitation-of-thymol-and-carvacrol-in-bovine-matrices-and-to-determine-residue-depletion-in-milk-and-tissues
#19
Sara Armorini, James E Yeatts, Keena A E Mullen, Sharon E Mason, Elmira Mehmeti, Kevin L Anderson, Steve P Washburn, Ronald E Baynes
Thymol and carvacrol may be present in several phytoceutical products but there are no well-defined methods to measure these compounds in meat and milk from treated animals. U.S. regulatory authorities deem their presence as an adulteration of food. A rapid and sensitive HS-SPME-GC-MS/MS method was developed for the detection of thymol and carvacrol in bovine milk, plasma, liver, kidney, and fat. Inter- and intraday precision values were all less than 15.7 and 20.2% for thymol and carvacrol, respectively. The accuracy was in ranges of 69...
October 11, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27701813/variations-in-essential-oil-compositions-of-lavandula-pubescens-lamiaceae-aerial-parts-growing-wild-in-yemen
#20
Rowaida N Al-Badani, Joyce Kelly R Da Silva, William N Setzer, Nasser A Awadh Ali, Bushra A Muharam, Ahmed J A Al-Fahad
Lavandula pubescens Decne. is one of five Lavandula species growing wild in Yemen. The plant is used in Yemeni traditional medicine, and the essential oil tends to be rich in carvacrol. In this work, L. pubescens was collected from eight different locations in Yemen, the essential oils obtained by hydrodistillation, and the oils analyzed by gas chromatography - mass spectrometry (GC-MS). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to differentiate between the L. pubescens samples...
October 4, 2016: Chemistry & Biodiversity
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