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Carvacrol

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https://www.readbyqxmd.com/read/28089589/synthesis-anticholinesterase-activity-and-molecular-modeling-study-of-novel-carbamate-substituted-thymol-carvacrol-derivatives
#1
Belma Zengin Kurt, Isil Gazioglu, Aydan Dag, Ramin Ekhteiari Salmas, Gülru Kayık, Serdar Durdagi, Fatih Sonmez
New thymol and carvacrol derivatives with the carbamate moiety were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 5-isopropyl-2-methylphenyl(3-fluorophenyl)carbamate (29) was found to be the most potent AChE inhibitor with IC50 values of 2.22μM, and 5-isopropyl-2-methylphenyl (4-fluorophenyl)carbamate (30) exhibited the strongest inhibition against BuChE with IC50 value of 0.02μM. Additionally, the result of H4IIE hepatoma cell toxicity assay for compounds 18, 20, 29, 30 and 35 showed negligible cell death at 0...
December 26, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28078244/carvacrol-attenuates-serum-levels-of-total-protein-phospholipase-a2-and-histamine-in-asthmatic-guinea-pig
#2
Mohammad Hossein Boskabady, Sedigheh Jalali, Negin Yahyazadeh, Mostafa Boskabady
OBJECTIVE: Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP), phospholipase A2 (PLA2) and histamine in sensitized guinea pigs was evaluated. MATERIALS AND METHODS: Sensitized guinea pigs were given drinking water alone (group S), drinking water containing three concentrations of carvacrol (40, 80 and 160 µg/ml) or dexamethasone. Serum levels of TP, PLA2 and histamine were examined I all sensitized groups as well as a non-sensitized control group (n=6 for each group)...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28063330/endolysin-lyssa97-is-synergistic-with-carvacrol-in-controlling-staphylococcus-aureus-in-foods
#3
Yoonjee Chang, Hyunjin Yoon, Dong-Hyun Kang, Pahn-Shick Chang, Sangryeol Ryu
LysSA97 is an endolysin encoded by the bacteriophage SA97, the genome sequence of which has been recently revealed. LysSA97 has lytic activity against a variety of Staphylococcus strains that cause foodborne illness. In order to improve its potential as a biocontrol agent against Staphylococcus, various types of essential oil-derived active compounds were tested in combination with LysSA97; carvacrol exhibited significant synergistic effects when combined with LysSA97. The synergistic antimicrobial activity between endolysin and carvacrol in food products, including milk and beef, were investigated...
December 27, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28062311/trpa1-and-trpv1-antagonists-do-not-inhibit-human-acidosis-induced-pain
#4
Matthias G Schwarz, Barbara Namer, Peter W Reeh, Michael J M Fischer
: Acidosis occurs in a variety of pathophysiological and painful conditions where it is thought to excite or contribute to excitation of nociceptive neurons. Despite potential clinical relevance the principal receptor for sensing acidosis is unclear, but several receptors have been proposed. We investigated the contribution of the acid sensing ion channels, TRPV1 and TRPA1 to peripheral pain signaling. We first established a human pain model using intra-epidermal injection of TRPA1 agonist carvacrol...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28062292/use-of-carvacrol-thymol-and-eugenol-for-biofilm-eradication-and-resistance-modifying-susceptibility-of-salmonella-enterica-serovar-typhimurium-strains-to-nalidixic-acid
#5
Hanene Miladi, Tarek Zmantar, Bochra Kouidhi, Yassine Chaabouni, Kacem Mahdouani, Amina Bakhrouf, Kamel Chaieb
The Aims of the study was to evaluate the antibacterial susceptibility and the biofilm eradication of three natural compounds carvacrol (CAR), thymol (TH) and eugenol (EUG), alone or in combination with nalidixic acid (NA) against twelve Salmonella Typhimurium strains. The minimum inhibitory concentration (MIC) and the minimum biofilm eradication concentration (BEC50) of the tested compounds (CAR, TH and EUG) and their combinations with NA were evaluated. In order to assess whether these bacteria had active efflux pumps, ethidium bromide (EtBr) accumulation assays was achieved using spectrophotometric accumulation assays...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28055127/lippia-origanoides-essential-oil-an-efficient-and-safe-alternative-to-preserve-food-cosmetic-and-pharmaceutical-products
#6
Camila Hernandes, Edieidia Souza Pina, Silvia H Taleb-Contini, Bianca Waléria Bertoni, Ivanice Maria Cestari, Lívia Greghi Espanha, Eliana A Varanda, Katyana França Bonini Camilo, Edson Zangiacome Martinez, Suzelei de Castro França, Ana Maria Soares Pereira
AIM: The aim of this work was to evaluated the efficacy and safety of Lippia origanoides essential oil as a preservative in industrial products. METHODS AND RESULTS: The composition, antimicrobial activity, mutagenic and toxic potential of L. origanoides was determined. Then the effect of essential oil as preservative in food, cosmetics and pharmaceutical products was evaluated. The essential oil of L. origanoides consisted mainly of oxygenated monoterpenes (38...
January 5, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28024521/a-novel-interpretation-of-the-fractional-inhibitory-concentration-index-the-case-origanum-vulgare-l-and-leptospermum-scoparium-j-r-et-g-forst-essential-oils-against-staphylococcus-aureus-strains
#7
Filippo Fratini, Simone Mancini, Barbara Turchi, Elisabetta Friscia, Luisa Pistelli, Giulia Giusti, Domenico Cerri
Origanum vulgare (oregano) and Leptospermum scoparium (manuka) were traditionally employed as natural remedies for infected wounds and skin injuries where Staphylococcus aureus is mainly involved. The first aim of this study was to investigate oregano and manuka essential oils (EOs) chemical compositions and evaluate their antibacterial activity (MIC, Minimum Inhibitory Concentration) against fourteen S. aureus wild strains. The second aim was to evaluate the antibacterial activities of oregano and manuka EOs mixed in different combination (FIC, Fractional Inhibitory Concentration) with an improved chequerboard technique...
January 2017: Microbiological Research
https://www.readbyqxmd.com/read/28012625/short-communication-interaction-of-the-isomers-carvacrol-and-thymol-with-the-antibiotics-doxycycline-and-tilmicosin-in-vitro-effects-against-pathogenic-bacteria-commonly-found-in-the-respiratory-tract-from-calves
#8
W Kissels, X Wu, R R Santos
Bovine respiratory disease is the major problem faced by cattle, specially calves, leading to reduced animal performance and increased mortality, consequently causing important economic losses. Hence, calves must be submitted to antibiotic therapy to counteract this infection usually initiated by the combination of environmental stress factors and viral infection, altering the animal's defense mechanism, and thus allowing lung colonization by the opportunistic bacteria Mannheimia haemolytica and Pasteurella multocida...
December 21, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28005325/cross-linked-polymer-stabilized-nanocomposites-for-the-treatment-of-bacterial-biofilms
#9
Ryan F Landis, Akash Gupta, Yi-Wei Lee, Li-Sheng Wang, Bianka Golba, Brice Couillaud, Roxane Ridolfo, Riddha Das, Vincent M Rotello
Infections caused by bacterial biofilms are an emerging threat to human health. Conventional antibiotic therapies are ineffective against biofilms due to poor penetration of the extracellular polymeric substance secreted by colonized bacteria coupled with the rapidly growing number of antibiotic-resistant strains. Essential oils are promising natural antimicrobial agents; however, poor solubility in biological conditions limits their applications against bacteria in both dispersed (planktonic) and biofilm settings...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/27986436/interaction-of-plant-essential-oil-terpenoids-with-the-southern-cattle-tick-tyramine-receptor-a-potential-biopesticide-target
#10
Aaron D Gross, Kevin B Temeyer, Tim A Day, Adalberto A Pérez de León, Michael J Kimber, Joel R Coats
An outbreak of the southern cattle tick, Rhipicephalus (Boophilus) microplus, (Canestrini), in the United States would have devastating consequences on the cattle industry. Tick populations have developed resistance to current acaricides, highlighting the need to identify new biochemical targets along with new chemistry. Furthermore, acaricide resistance could further hamper control of tick populations during an outbreak. Botanically-based compounds may provide a safe alternative for efficacious control of the southern cattle tick...
December 14, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27982301/assessment-of-different-lippia-sidoides-genotypes-regarding-their-acaricidal-activity-against-rhipicephalus-boophilus-microplus
#11
Alexandra Martins Dos Santos Soares, Tatiane Aranha Penha, Sandra Alves de Araújo, Elizangela Mércia Oliveira Cruz, Arie Fitzgerald Blank, Livio Martins Costa-Junior
The aim of this study was to select different genotypes of Lippia sidoides with the highest activity against larvae and engorged females of the tick Rhipicephalus (Boophilus) microplus. The germplasms studied were LSID006, LSID102, LSID103 and LSID104. The LSID104 genotype, that presented carvacrol as a major constituent, was the germplasm with the worst larvicide effect (LC50 2.99 mg/mL). The LSID006 genotype was the least effective against engorged females (LC50 12.46 mg/mL), and it was chemically similar to the LSID102 genotype, which presented the highest acaricide activity (LC50 2...
October 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27916558/role-of-carvacrol-in-cardioprotection-against-myocardial-ischemia-reperfusion-injury-in-rats-through-activation-of-mapk-erk-and-akt-enos-signaling-pathways
#12
Yunping Chen, Lina Ba, Wei Huang, Yan Liu, Hao Pan, E Mingyao, Pilong Shi, Ye Wang, Shuzhi Li, Hanping Qi, Hongli Sun, Yonggang Cao
Carvacrol (CAR) is a compound isolated from some essential oils, many studies have demonstrated its therapeutic potential on different diseases. This study aims to evaluate the protective effect of CAR against myocardial ischemia/reperfusion (I/R) injury in rats. Male adult rats underwent ligation of the left anterior descending coronary artery (LAD) in I/R models. Rats were treated with CAR after LAD. The levels of I/R- induced infarct size, cardiomyocyte apoptosis and cardiac functional impairment were examined...
December 1, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27915173/effect-of-prolonged-water-stress-on-essential-oil-content-compositions-and-gene-expression-patterns-of-mono-and-sesquiterpene-synthesis-in-two-oregano-origanum-vulgare-l-subspecies
#13
Mohammad Reza Morshedloo, Lyle E Craker, Alireza Salami, Vahideh Nazeri, Hyunkyu Sang, Filippo Maggi
Origanum vulgare L., recognized throughout the world as a popular medicinal and flavoring herb, contains a wide array of medicinally active components, including phenolic glucosides, flavonoids, tannins, sterols and high amounts of terpenoids. Especially the latter are often extracted by hydrodistillation resulting in the so-called essential oil that is rich in monoterpenes (e.g. carvacrol, thymol, linalyl acetate) and/or sesquiterpenes (e.g. (E)-β-caryophyllene, germacrene D, bicyclogermacrene, β-caryophyllene oxide)...
November 28, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27905512/plant-phenolic-volatiles-inhibit-quorum-sensing-in-pectobacteria-and-reduce-their-virulence-by-potential-binding-to-expi-and-expr-proteins
#14
Janak Raj Joshi, Netaly Khazanov, Hanoch Senderowitz, Saul Burdman, Alexander Lipsky, Iris Yedidia
Quorum sensing (QS) is a population density-dependent regulatory system in bacteria that couples gene expression to cell density through accumulation of diffusible signaling molecules. Pectobacteria are causal agents of soft rot disease in a range of economically important crops. They rely on QS to coordinate their main virulence factor, production of plant cell wall degrading enzymes (PCWDEs). Plants have evolved an array of antimicrobial compounds to anticipate and cope with pathogens, of which essential oils (EOs) are widely recognized...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884791/immunomodulatory-effect-of-characterized-extract-of-zataria-multiflora-on-th1-th2-and-th17-in-normal-and-th2-polarization-state
#15
Majid Kianmehr, Abdolrahim Rezaei, Mahmoud Hosseini, Mohammad Reza Khazdair, Ramin Rezaee, Vahid Reza Askari, Mohammad Hossein Boskabady
The effect of the extract of Zataria multiflora (Z. multiflora) on IFN-γ, FOXP3, IL-4, TGF-β, and IL-17 gene expression was evaluated in cultured splenocytes obtained from control, nontreated asthma or sensitized mice (group S), Sensetized animals treated with dexamethasone or three concentrations of Z. multiflora extract (200, 400 and 800 μg/ml) (n = 6, for each group). IFN-γ and FOXP3 gene expressions were significantly decreased (P < 0.001 for both cases) but IL-4 (P < 0.001) and IL-17 (P < 0...
January 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27878214/lethal-and-sublethal-effects-of-essential-oil-of-lippia-sidoides-verbenaceae-and-monoterpenes-on-chagas-disease-vector-rhodnius-prolixus
#16
Marcela B Figueiredo, Geovany A Gomes, Jayme M Santangelo, Emerson G Pontes, Patricia Azambuja, Elói S Garcia, Mário G de Carvalho
The aim of this study was to identify the composition of the essential oil from leaves of Lippia sidoides (EOLS), a typical shrub commonly found in the dry northeast of Brazil, popularly known as "alecrim-pimenta". Additionally, we investigated the nymphicidal, ovicidal, phagoinhibitory and excretion effects of EOLS, its major constituent thymol and its isomer carvacrol, on fourth instar nymphs and eggs of Rhodnius prolixus, the Chagas' disease vector. The nymphicidal and ovicidal activity of thymol, carvacrol, and EOLS was assessed by tests using impregnated Petri dishes...
January 1, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/27872717/the-antibacterial-effect-of-ziziphora-clinopodioides-essential-oil-and-nisinagainst-salmonella-typhimurium-and-staphylococcus-aureus-in-doogh-a-yoghurt-based-iranian-drink
#17
Yasser Shahbazi
Doogh is the most popular and commonly consumed yoghurt-based Iranian drink. The aim of this study was to investigate the antibacterial effects of Ziziphora clinopodioides essential oil (ZEO) at 0.10 and 0.20% concentrations, nisin at 250 and 500 IU mL(-1), and their combination against Salmonella typhimurium and Staphylococcusaureus in doogh during storage at 4 ˚C for  9 days. Nine batches were studied as follows: control: no ZEO or nisin added, A: 0.10% ZEO, B: 0.20% ZEO, C: 250 IU mL(-1) nisin, D: 500 IU mL(-1) nisin, E: 0...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27866466/preventive-effect-of-carvacrol-against-oxidative-damage-in-aged-rat-liver
#18
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
The present study was designed to investigate the changes in activities of antioxidant enzymes and lipid peroxidation level in the liver of 2, 10 and 20 months old rats, and to see whether these changes are restored to those of the two month old rats after carvacrol treatment. Male rats of 2, 10, and 20 months (n = 10 for each group) were used for all the experiments. The aged rats (10 and 20 months old) were given carvacrol (15 mg/day per body weight) for 30 days. Control animals received an equal volume of vehicle...
November 21, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/27865956/safranal-and-its-analogs-inhibit-escherichia-coli-atp-synthase-and-cell-growth
#19
Mason Liu, Amon Amini, Zulfiqar Ahmad
Safranal, a dominant component of saffron, is known to have antitumor, cytotoxic, and antibacterial properties. In this study, we examined safranal and its structural analogs-thymol, carvacrol, damascenone, cuminol, 2,6,6-trimethyl-2-cyclohexene-1,4-dione (TMCHD), 4-isopropylbenzyl bromide (IPBB), and 4-tert-butylphenol (TBP) induced inhibition of Escherichia coli membrane bound F1Fo ATP synthase. Safranal and its analogs inhibited wild-type enzyme to variable degrees. While safranal caused 100% inhibition of wild-type F1Fo ATP synthase, only about 50% inhibition occurred for αR283D mutant ATP synthase...
February 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27855883/essential-oil-composition-total-phenolic-flavonoid-contents-and-antioxidant-activity-of-thymus-species-collected-from-different-regions-of-iran
#20
Behnaz Tohidi, Mehdi Rahimmalek, Ahmad Arzani
In this study, the essential oil (EO) composition, flavonoid and phenolic contents, and antioxidant activities of fourteen Thymus accessions belonging to ten species were evaluated. Gas chromatography-mass spectrometry (GC-MS) analysis revealed the presence of 38 compounds with the major constituents including thymol (12.4-79.74%), carvacrol (4.37-42.14%), geraniol (0.3-22.44%), and p-cymene (0.8-12.86%). Cluster analysis identified three groups of high thymol, geraniol/linalool, and high carvacrol. The highest phenolic and flavonoid contents were detected in T...
April 1, 2017: Food Chemistry
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