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Ellen Games, Marina Guerreiro, Fernanda R Santana, Nathalia M Pinheiro, Emerson A de Oliveira, Fernanda D T Q S Lopes, Clarice R Olivo, Iolanda F L C Tibério, Mílton A Martins, João Henrique G Lago, Carla M Prado
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and inflammation. Natural products, such as monoterpenes, displayed anti-inflammatory and anti-oxidant activities and can be used as a source of new compounds to COPD treatment. Our aim was to evaluate, in an elastase-induced pulmonary emphysema in mice, the effects of and underlying mechanisms of three related natural monoterpenes (p-cymene, carvacrol and thymol) isolated from essential oil from leaves Lippia sidoides Cham...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Dadasaheb D Wadikar, Prakash E Patki
The herb Coleus aromaticus belonging to Lamiaceae family and Coleus genus is known by numerous names in different parts of the world and several language specific vernacular names. The herb has been extensively studied as well as reported in several fields of science. The multiple potential of the herb includes allelopathic potential, antibacterial property, antimicrobial activity, insecticidal property; free radical scavenging and radio-protective components from herb extracts and most recently the appetizing potential of the herb have been reported...
July 2016: Journal of Food Science and Technology
Sara Armorini, James E Yeatts, Keena A E Mullen, Sharon E Mason, Elmira Mehmeti, Kevin L Anderson, Steve P Washburn, Ronald E Baynes
Thymol and carvacrol may be present in several phytoceutical products but there are no well-defined methods to measure these compounds in meat and milk from treated animals. U.S. regulatory authorities deem their presence as an adulteration of food. A rapid and sensitive HS-SPME-GC-MS/MS method was developed for the detection of thymol and carvacrol in bovine milk, plasma, liver, kidney, and fat. Inter- and intraday precision values were all less than 15.7 and 20.2% for thymol and carvacrol, respectively. The accuracy was in ranges of 69...
October 11, 2016: Journal of Agricultural and Food Chemistry
Rowaida N Al-Badani, Joyce Kelly R Da Silva, William N Setzer, Nasser A Awadh Ali, Bushra A Muharam, Ahmed J A Al-Fahad
Lavandula pubescens Decne. is one of five Lavandula species growing wild in Yemen. The plant is used in Yemeni traditional medicine, and the essential oil tends to be rich in carvacrol. In this work, L. pubescens was collected from eight different locations in Yemen, the essential oils obtained by hydrodistillation, and the oils analyzed by gas chromatography - mass spectrometry (GC-MS). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) were used to differentiate between the L. pubescens samples...
October 4, 2016: Chemistry & Biodiversity
Livio M Costa-Júnior, Robert J Miller, Péricles B Alves, Arie F Blank, Andrew Y Li, Adalberto A Pérez de León
Plant-derived natural products can serve as an alternative to synthetic compounds for control of ticks of veterinary and medical importance. Lippia gracilis is an aromatic plant that produces essential oil with high content of carvacrol and thymol monoterpenes. These monoterpenes have high acaricidal activity against Rhipicephalus (Boophilus) microplus. However, there are no studies that show efficacy differences of essential oils between susceptible and organophosphate resistant strains of R. (B.) microplus...
September 15, 2016: Veterinary Parasitology
Juliane C Silva, Jackson R G S Almeida, Jullyana S S Quintans, Rajiv Gandhi Gopalsamy, Saravanan Shanmugam, Mairim Russo Serafini, Maria R C Oliveira, Bruno A F Silva, Anita O B P B Martins, Fyama F Castro, Irwin R A Menezes, Henrique D M Coutinho, Rita C M Oliveira, Parimelazhagan Thangaraj, Adriano A S Araújo, Lucindo J Quintans-Júnior
Orofacial pain is associated with diagnosis of chronic pain of head, face, mouth, neck and all the intraoral structures. Carvacrol, a naturally occurring isoprenoid with diverse class of biological activities including anti-inflammatory, analgesic, antitumor and antioxidant properties. Now, the antinociceptive effect was studied in mice pretreatment with carvacrol (CARV) and β-cyclodextrin complex containing carvacrol (CARV-βCD) in formalin-, capsaicin-, and glutamate- induced orofacial nociception. Mice were pretreated with vehicle (0...
September 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tong-Hong Wang, Shih-Min Hsia, Chi-Hao Wu, Shun-Yao Ko, Michael Yuanchien Chen, Yin-Hua Shih, Tzong-Ming Shieh, Li-Chuan Chuang, Ching-Yi Wu
The aim of the present study was to determine the antibacterial activities of the phenolic essential oil (EO) compounds hinokitiol, carvacrol, thymol, and menthol against oral pathogens. Aggregatibacter actinomycetemcomitans, Streptococcus mutans, Methicillin-resistant Staphylococcus aureus (MRSA), and Escherichia. coli were used in this study. The minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), bacterial growth curves, temperature and pH stabilities, and synergistic effects of the liquid and vapor EO compounds were tested...
2016: PloS One
Julia Fabbri, Marina A Maggiore, Patricia E Pensel, Guillermo M Denegri, Liesel B Gende, María C Elissondo
Currently, benzimidazoles are used as chemotherapeutic agents and as a complement to surgery and PAIR in the treatment of cystic echinococcosis (CE). They are generally applied at high doses causing side effects and, 50% of cases do not respond favorably to such chemotherapy. The use of essential oils obtained by distillation from aromatic plants would be an effective alternative or complementary to the synthetic compounds, because would not bring the appearance of side effects. Carvacrol and his isomer thymol are the main phenolic components from essential oils of Origanum vulgare (oregano) and Thymus vulgaris (thyme)...
September 17, 2016: Acta Tropica
Nameer Khairullah Mohammed, Mohd Yazid Abd Manap, Chin Ping Tan, Belal J Muhialdin, Amaal M Alhelli, Anis Shobirin Meor Hussin
The Nigella sativa L. popularly referred to as black seeds are widely used as a form of traditional nutrition and medicine. N. sativa seeds were used for the extraction of their oil by way of supercritical fluid extraction (SFE) and cold press (CP) to determine the physicochemical properties, antioxidant activity, and thermal behavior. The GC-MS results showed the primary constituents in the Nigella sativa oil (NSO) were Caryophyllene (17.47%) followed by thymoquinone (TQ) (11.80%), 1,4-Cyclohexadiene (7.17%), longifolene (3...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
D O Castro, N Tabary, B Martel, A Gandini, N Belgacem, J Bras
Current investigations deal with new surface functionalization strategy of nanocrystalline cellulose-based substrates to impart active molecule release properties. In this study, cellulose nanocrystals (CNC) were surface-functionalized with β-cyclodextrin (β-CD) using succinic acid (SA) and fumaric acid (FA) as bridging agents. The main objective of this surface modification performed only in aqueous media was to obtain new active materials able to release antibacterial molecules over a prolonged period of time...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
María José Grande Burgos, Maria Luisa Fernández Márquez, Rubén Pérez Pulido, Antonio Gálvez, Rosario Lucas López
Eggs may contain extraintestinal pathogenic (ExPEC) and diarrheogenic (DEC) Escherichia coli which in addition may carry antibiotic resistance. The wide use of biocides and disinfectants in the food industry may induce biocide tolerance in bacteria. The aim of the present study was to evaluate biocide tolerance and antibiotic resistance in E. coli from hen egg shells. A total of 27 isolates obtained from a screening of 180 eggs were studied. Seven isolates carried both eae and bfpA genes of typical enteropathogenic E...
December 5, 2016: International Journal of Food Microbiology
Marimuthu Govindarajan, Shine Kadaikunnan, Naiyf S Alharbi, Giovanni Benelli
The recent outbreaks of dengue, chikungunya, and Zika virus highlighted the pivotal importance of mosquito vector control in tropical and subtropical areas worldwide. However, mosquito control is facing hot challenges, mainly due to the rapid development of pesticide resistance in Culicidae and the limited success of biocontrol programs on Aedes mosquitoes. In this framework, screening botanicals for their mosquitocidal potential may offer effective and eco-friendly tools in the fight against mosquitoes. In the present study, the essential oil (EO) obtained from the medicinal plant Origanum scabrum was analyzed by GC-MS and evaluated for its mosquitocidal and repellent activities towards Anopheles stephensi, Aedes aegypti, Culex quinquefasciatus, and Culex tritaeniorhynchus...
September 8, 2016: Environmental Science and Pollution Research International
Monay Al Hafi, Marc El Beyrouthy, Naim Ouaini, Didier Stien, Douglas Rutledge, Sylvain Chaillou
The essential oils were extracted by hydrodistillation from Satureja cuneifolia, Satureja thymbra, Coridothymus capitatus, Thymus syriacus and Thymbra spicata growing wild in Lebanon. Their phytochemical analysis performed by GC/MS showed that the aforementioned species are characterized either by carvacrol (60.9%) or thymol (54.3%) or by a more or less equal amounts of these two phenols. Assessment of their in vitro antimicrobial activity against Candida albicans and six pathogenic bacteria using the broth dilution method revealed that the tested oils have a broad activity spectrum with minimum inhibitory concentration ranging from 0...
September 1, 2016: Chemistry & Biodiversity
Narcisa Mandras, Antonia Nostro, Janira Roana, Daniela Scalas, Giuliana Banche, Valeria Ghisetti, Simonetta Del Re, Giacomo Fucale, Anna Maria Cuffini, Vivian Tullio
BACKGROUND: The management of Candida infections faces many problems, such as a limited number of antifungal drugs, toxicity, resistance of Candida to commonly antifungal drugs, relapse of Candida infections, and the high cost of antifungal drugs. Though azole antifungal agents and derivatives continue to dominate as drugs of choice against Candida infections, there are many available data referring to the anticandidal activity of essential oils. Since we have previous observed a good antimicrobial activity of some essential oils against filamentous fungi, the aim of this study was to extend the research to evaluate the activity of the same oils on Candida albicans, C...
2016: BMC Complementary and Alternative Medicine
Abderrahmane Djouahri, Saka Boualem, Lynda Boudarene, Aoumeur Baaliouamer
In the present work, the hydrodistillation (HD) and microwave-assisted hydrodistillation (MAHD) kinetics of essential oil extracted from Tetraclinis articulata (Vahl) Masters wood was conducted, in order to assess the impact of extraction time and technique on chemical composition and biological activities. GC and GC-MS analyses showed significant differences between the extracted essential oils, where each family class or component presents a specific kinetic according to extraction time, technique and especially for the major components: camphene, linalool, cedrol, carvacrol and α-acorenol...
August 27, 2016: Chemistry & Biodiversity
Sara A Burt, Simone J M Adolfse, Dina S A Ahad, Monique H G Tersteeg-Zijderveld, Betty G M Jongerius-Gortemaker, Jan A Post, Holger Brüggemann, Regiane R Santos
Essential oils and organic acids are used as feed additives to improve health status and reduce colonization with pathogens. Although bactericidal in vitro, concentrations achieved in the animal gut are probably not lethal to pathogens. The aim of this study was to investigate the effects of cinnamaldehyde, carvacrol and cinnamic, lactic and propionic acids on the ability of Salmonella typhimurium ATCC 14028 (ST) to invade intestinal epithelial cells (IPEC-J2) and on the expression levels of immune related genes in the cells...
August 25, 2016: Phytotherapy Research: PTR
Stefanie Bressan Waller, Isabel Martins Madrid, Anna Luiza Silva, Luciana Laitano Dias de Castro, Marlete Brum Cleff, Vanny Ferraz, Mário Carlos Araújo Meireles, Régis Zanette, João Roberto Braga de Mello
This study evaluated the chemical, cytotoxic and anti-Sporothrix brasiliensis properties of commercial essential oils of rosemary (Rosmarinus officinalis L.), oregano (Origanum vulgare L.) and marjoram (Origanum majorana L.). Chemical composition of the oils was identified through gas chromatography with flame ionization detector, and cytotoxicity was performed through MTT assay in VERO cell line. Anti-S. brasiliensis activity was performed according to the CLSI M38-A2 guidelines using isolates obtained from cats and dogs...
August 16, 2016: Mycopathologia
Lang-Hong Wang, Man-Sheng Wang, Xin-An Zeng, De-Ming Gong, Yan-Bo Huang
BACKGROUND: Some antibacterial agents exert their antimicrobial action by targeting the cytoplasmic macromolecules, such as proteins or nucleic acids, to disturb the properties of macromolecules that may deeply influnence their biological activities and functions. Cinnamaldehyde (CIN) is a natural antibacterial ingredient found in the bark and leaves of cinnamon trees. METHODS: The inhibitory mechanism of a typical enzyme, β-galactosidase by CIN was investigated by UV-visible, fluorescence, 3-D spectroscopy, circular dichroism, atomic force microscopy and molecular modeling studies...
August 12, 2016: Biochimica et Biophysica Acta
Richard Karban, Patrick Grof-Tisza, James D Blande
Plants that are damaged by herbivores emit complex blends of volatile compounds that often cause neighboring branches to induce resistance. Experimentally clipped sagebrush foliage emits volatiles that neighboring individuals recognize and respond to. These volatiles vary among individuals within a population. Two distinct types are most common with either thujone or camphor as the predominate compound, along with other less common types. Individuals respond more effectively to cues from the same type, suggesting that some of the informative message is contained in the compounds that differentiate the types...
August 2016: Journal of Chemical Ecology
Hanene Miladi, Tarek Zmantar, Yassine Chaabouni, Kais Fedhila, Amina Bakhrouf, Kacem Mahdouani, Kamel Chaieb
In this study thymol (THY) and carvacrol (CAR), two monoterpenic phenol produced by various aromatic plants, was tested for their antibacterial and efflux pump inhibitors potencies against a panel of clinical and foodborne pathogenes. Our results demonstrated a substantial susceptibility of the tested bacteria toward THY and CAR. Especially, THY displayed a strong inhibitory activity (MIC's values ranged from 32 to 64 μg/mL) against the majority of the tested strains compared to CAR. Moreover, a significant reduction in MIC's of TET and benzalkonium chloride (QAC) were noticed when tested in combinations with THY and CAR...
October 2016: Microbial Pathogenesis
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