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https://www.readbyqxmd.com/read/29785774/thymol-thyme-and-other-plant-sources-health-and-potential-uses
#1
REVIEW
Bahare Salehi, Abhay Prakash Mishra, Ila Shukla, Mehdi Sharifi-Rad, María Del Mar Contreras, Antonio Segura-Carretero, Hannane Fathi, Nafiseh Nasri Nasrabadi, Farzad Kobarfard, Javad Sharifi-Rad
Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. This plant, native to Mediterranean regions, is commonly used as a culinary herb and also with a long history of use for different medicinal purposes. Nowadays, thymol and thyme present a wide range of functional possibilities in pharmacy, food, and cosmetic industry...
May 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29771453/functionalization-of-lipid-based-nutrient-supplement-with-%C3%AE-cyclodextrin-inclusions-of-oregano-essential-oil
#2
Shashank Gaur, Emely C Lopez, Ankur Ojha, Juan E Andrade
Intestinal parasitic infection is one of the main causes of acute undernutrition in children. Oral consumption of oregano essential oil (OEO) can reduce intestinal parasitic infections, however, its addition to therapeutic and supplementary foods is hampered by its undesirable flavor. The objective of this study was to develop a functional lipid-based nutrient supplement (LNS) containing OEO, which is stable, acceptable and provides targeted intestinal delivery of bioactive. β-cyclodextrin (β-CyD) inclusion complexes of OEO (β-CyD-OEO), and carvacrol (β-CyD-CV) (1:1 molar) were prepared using slurry complexation (-20 °C) method and characterized based on encapsulation efficiency, moisture content, morphology, and 2-phase in vitro digestion stability...
May 17, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29770558/pharmacokinetic-and-antimicrobial-activity-of-a-new-carvacrol-based-product-against-a-human-pathogen-campylobacter-jejuni
#3
Marion Allaoua, Pierre Etienne, Virginie Noirot, Jean-Luc Carayon, Nathan Téné, Elsa Bonnafé, Michel Treilhou
AIM: In vitro and in vivo studies were conducted to test a new carvacrol-based product designed to delay the carvacrol release so that it could reach the caeca of broiler chickens in order to control Campylobacter jejuni. METHODS AND RESULTS: Antimicrobial activity of carvacrol, a constituent of oregano and thyme essential oil, has been demonstrated against C. jejuni in vitro, and this compound was found beneficial for broiler growth. Here, we tested a new liquid formulation that did not change the antibacterial efficacy of carvacrol against C...
May 16, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29769620/carvacrol-and-linalool-co-loaded-in-%C3%AE-cyclodextrin-grafted-chitosan-nanoparticles-as-sustainable-biopesticide-aiming-pest-control
#4
Estefânia V R Campos, Patrícia L F Proença, Jhones L Oliveira, Anderson E S Pereira, Lígia Nunes de Morais Ribeiro, Fabrício O Fernandes, Kelly C Gonçalves, Ricardo A Polanczyk, Tatiane Pasquoto-Stigliani, Renata Lima, Cirano C Melville, Jaqueline F Della Vechia, Daniel J Andrade, Leonardo F Fraceto
Pesticides are the main tactics for pest control because they reduce the pest population very fast and their efficiency does not depend on abiotic factors. However, the indiscriminate use of these substances can speed up the development of resistant populations and causing environmental contamination. Therefore, alternative methods of pest control are sought, such as the use of botanical compounds. Nanoencapsulation of volatile compounds has been shown to be an important tool that can be used to overcome the lack of stability of these compounds...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29749766/evaluation-of-the-impact-of-varied-carvacrol-concentrations-on-salmonella-recovery-in-oregano-and-how-corn-oil-can-minimize-the-effect-of-carvacrol-during-preenrichment
#5
Junia Jean-Gilles Beaubrun, Nicole Addy, Zachary Keltner, Samantha Farris, Laura Ewing, Gopal Gopinath, Darcy E Hanes
Phenolic compounds, like carvacrol, in oregano interfere with the detection of foodborne pathogens such as Salmonella enterica. Carvacrol concentration varies based on plant cultivars and growth region. Six oregano cultivars were used to compare the impact of carvacrol concentration on Salmonella and to evaluate the effectiveness of corn oil to help increase Salmonella survival for detection. The results of Agilent 1200 series high-performance liquid chromatography analysis showed that carvacrol concentration in the six oregano cultivars ranged from 64 to 11,200 ppm...
May 11, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29748726/in-vitro-and-in-silico-studies-of-terpenes-terpenoids-and-related-compounds-with-larvicidal-and-pupaecidal-activity-against-culex-quinquefasciatus-say-diptera-culicidae
#6
S Andrade-Ochoa, J Correa-Basurto, L M Rodríguez-Valdez, L E Sánchez-Torres, B Nogueda-Torres, G V Nevárez-Moorillón
BACKGROUND: In order to develop new larvicidal agents derived from phytochemicals, the larvicidal activity of fifty molecules that are constituent of essential oils was evaluated against Culex quinquefasciatus Say. Terpenes, terpenoids and phenylpropanoids molecules were included in the in vitro evaluation, and QSAR models using genetic algorithms were built to identify molecular and structural properties of biological interest. Further, to obtain structural details on the possible mechanism of action, selected compounds were submitted to docking studies on sterol carrier protein-2 (SCP-2) as possible target...
May 10, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/29744941/carvacrol-and-human-health-a-comprehensive-review
#7
REVIEW
Mehdi Sharifi-Rad, Elena Maria Varoni, Marcello Iriti, Miquel Martorell, William N Setzer, María Del Mar Contreras, Bahare Salehi, Azam Soltani-Nejad, Sadegh Rajabi, Mercedeh Tajbakhsh, Javad Sharifi-Rad
Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety...
May 9, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29741243/antibacterial-potential-of-phytochemicals-alone-or-in-combination-with-antimicrobials-against-fish-pathogenic-bacteria
#8
G Bandeira Junior, F J Sutili, L T Gressler, V L Ely, B P Silveira, C Tasca, M Reghelin, L B Matter, A P C Vargas, B Baldisserotto
AIMS: This study investigated the antibacterial activity of five phytochemicals (carvacrol, citral, eugenol, linalool, and thymol) alone or in combination with florfenicol or oxytetracycline against bacteria isolated from silver catfish (Rhamdia quelen). We also analyzed the potential of these compounds to inhibit biofilm formation and hemolysis caused by the bacteria. METHODS AND RESULTS: Bacteria were tested with antimicrobials to calculate the multiple antibiotic resistance (MAR)...
May 9, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29736255/addition-of-capsicum-oleoresin-carvacrol-cinnamaldehyde-and-their-mixtures-to-the-broiler-diet-ii-effects-on-meat-quality
#9
Hasan Hüseyin İpçak, Ahmet Alçiçek
Background: In recent years, with the prohibition of antibiotics used as growth stimulants in the nutrition of farm animals, researchers have searched for alternative natural and reliable products in order to be able to sustain the developments experienced during the use of antibiotics and to overcome the possible inconveniences. In this context, studies on evaluation of essential oils in poultry nutrition have been reported to improve the utilization of feed, stimulate the release of digestive enzymes, increase absorption in the stomach and intestines, antimicrobial and anti-parasitic effects and thus, can be an alternative to antibiotics and improve meat quality as well...
2018: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/29726703/chemical-characterization-and-antifungal-activity-of-origanum-vulgare-thymus-vulgaris-essential-oils-and-carvacrol-against-malassezia-furfur
#10
Vittorio Vinciguerra, Florencia Rojas, Viviana Tedesco, Gustavo Giusiano, Letizia Angiolella
The composition of the essential oils (EOs) of O. vulgare L. EO and T. vulgaris EO, were analyzed by GC and GC-MS. Antifungal activities of the EOs and its main component, carvacrol, were evaluated against 27 clinical isolates of Malassezia furfur. Minimum inhibitory concentrations (MICs) were measured according to the broth microdilution protocols by Clinical and Laboratory Standards Institute (CLSI) modified for Malassezia spp. EOs and carvacrol showed low MIC values ranged 450-900 μg/ml against M. furfur...
May 4, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29724221/use-of-pinus-sylvestris-l-pinaceae-origanum-vulgare-l-lamiaceae-and-thymus-vulgaris-l-lamiaceae-essential-oils-and-their-main-components-to-enhance-itraconazole-activity-against-azole-susceptible-not-susceptible-cryptococcus-neoformans-strains
#11
Daniela Scalas, Narcisa Mandras, Janira Roana, Roberta Tardugno, Anna Maria Cuffini, Valeria Ghisetti, Stefania Benvenuti, Vivian Tullio
BACKGROUND: Cryptococcal infections, besides being a problem for immunocompromised patients, are occasionally being a problem for immunocompetent patients. In addition, the lower susceptibility of this yeast to azoles is a growing problem in health care. To date, there are very few molecules with any activity towards Cryptococcus neoformans, leading to heightened interest in finding new alternatives or adjuvants to conventional drugs for the treatment of mycosis caused by this yeast. Since the essential oils (EOs) are considered as a potential rich source of bioactive antimicrobial compounds, we evaluated the antifungal activity of Origanum vulgare (oregano), Pinus sylvestris (pine), and Thymus vulgaris (thyme red) EOs, and their components (α-pinene, carvacrol, thymol) compared with fluconazole, itraconazole, and voriconazole, against C...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29717370/chemical-composition-and-assessment-of-larvicidal-and-repellent-capacity-of-14-lamiaceae-essential-oils-against-aedes-albopictus
#12
Athanassios Giatropoulos, Athanasios Kimbaris, Αntonios Michaelakis, Dimitrios P Papachristos, Moschos G Polissiou, Nickolaos Emmanouel
In the current laboratory study, 14 essential oils (EOs) derived from 12 Lamiaceae plant species and their major components were screened for their larvicidal and repellent properties against Aedes albopictus, an invasive mosquito species of great medical importance. The results of toxicity bioassays revealed that the EOs from Thymus vulgaris, Ocimum basilicum, Origanum dictamnus, Origanum majorana, and Origanum vulgare, as well as their major components (terpenes), namely thymol, carvacrol, p-cymene, and γ-terpinene exerted the highest larvicidal effect...
May 1, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29692550/effect-of-soil-application-of-humic-acid-on-nutrients-uptake-essential-oil-and-chemical-compositions-of-garden-thyme-thymus-vulgaris-l-under-greenhouse-conditions
#13
Alireza Noroozisharaf, Maryam Kaviani
Humic acid is natural biological organic, which has a high effect on plant growth and quality. However, the mechanisms of the promoting effect of humic acid on the volatile composition were rarely reported. In this study, the effects of soil application of humic acid on the chemical composition and nutrients uptake of Thymus vulgaris were investigated. Treatments comprised 0, 50, 75 and 100 g m-2 . Essential oil was extracted by hydrodistillation and analyzed using GC-MS and GC-FID. Essential oil content was enhanced by increase of the humic acid level and its content ranged from 0...
May 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29680052/antimicrobial-antioxidant-and-sensory-features-of-eugenol-carvacrol-and-trans-anethole-in-active-packaging-for-organic-ready-to-eat-iceberg-lettuce
#14
Justyna Wieczyńska, Ivana Cavoski
In this study, bio-based emitting sachets containing eugenol (EUG), carvacrol (CAR) and trans-anethole (ANT) were inserted into cellulose (CE) and polypropylene (PP) pillow packages of organic ready-to-eat (RTE) iceberg lettuce to investigate their functional features. EUG, CAR and ANT sachets in CE; and CAR in PP packages showed antimicrobial activities against coliforms (Δlog CFU g-1 of -1.38, -0.91, -0.93 and -0.93, respectively). EUG and ANT sachets in both packages reduced discoloration (ΔE of 9.5, 1...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29672979/interaction-of-ascaridole-carvacrol-and-caryophyllene-oxide-from-essential-oil-of-chenopodium-ambrosioides-l-with-mitochondria-in-leishmania-and-other-eukaryotes
#15
Lianet Monzote, Gerald Geroldinger, Matthias Tonner, Ramón Scull, Sritama De Sarkar, Sophie Bergmann, Markus Bacher, Katrin Staniek, Mitali Chatterjee, Thomas Rosenau, Lars Gille
The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major EO compounds carvacrol, caryophyllene oxide (Caryo), and the antileishmanial endoperoxide ascaridole (Asc) on mitochondrial functions in Leishmania tarentolae promastigotes (LtP). EO and Caryo were able to partially inhibit the leishmanial electron transport chain, whereas other components failed to demonstrate a direct immediate effect...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29668311/chemical-composition-and-antimicrobial-activities-of-essential-oil-from-wedelia-urticifolia-growing-wild-in-hunan-province-china
#16
Junpeng Hu, Mengmeng Jia, Liang Zhu
The essential oil obtained from Wedelia urticifolia growing in Hunan Province, China, was analyzed for the first time by capillary GC and GC-MS. A total of 67 constituents, representing 98.68% in essential oil were identified. The major constituents of the oil were: α-pinene (8.85%), limonene (6.38%), carvacrol (6.15%), caryophyllene (6.08%), spathulenol (5.49%), sabinene (5.36%), camphor (4.34%). Antimicrobial potential of oil against bacterial strains (Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis, and Staphylococcus aureus), yeast strains (Hansenula anomala and Saccharomy cescerevisiae) and molds (Aspergillus niger, Chaetomium globosum, Mucor racemosus, and Monascus anka) was determined by disc diffusion method and broth micro dilution method, respectively...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29656020/odorant-binding-protein-based-identification-of-natural-spatial-repellents-for-the-african-malaria-mosquito-anopheles-gambiae
#17
Thomas Kröber, Konstantinos Koussis, Martine Bourquin, Panagiota Tsitoura, Maria Konstantopoulou, Taiwo Sam Awolola, Francesca R Dani, Huili Qiao, Paolo Pelosi, Kostas Iatrou, Patrick M Guerin
There is increasing interest in the development of effective mosquito repellents of natural origin to reduce transmission of diseases such as malaria and yellow fever. To achieve this we have employed an in vitro competition assay involving odorant-binding proteins (OBPs) of the malaria mosquito, Anopheles gambiae, with a predominantly female expression bias to identify plant essential oils (EOs) containing bioactive compounds that target mosquito olfactory function. EOs and their fractions capable of binding to such OBPs displayed repellence against female mosquitoes in a laboratory repellent assay...
April 12, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29609011/relaxant-effect-of-lippia-origanoides-essential-oil-in-guinea-pig-trachea-smooth-muscle-involves-potassium-channels-and-soluble-guanylyl-cyclase
#18
Pedro Modesto Nascimento Menezes, Mariana Coelho Brito, Gabriela Olinda de Paiva, Carine Oliveira Dos Santos, Lenaldo Muniz de Oliveira, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima, Angélica Maria Lucchese, Fabrício Souza Silva
ETHNOPHARMACOLOGICAL RELEVANCE: Lippia origanoides H.B.K. is an aromatic species used in folk medicine to treat respiratory diseases, including asthma. AIM OF THE STUDY: The aim of this work was to evaluate the relaxing potential and mechanism of action of the L. origanoides (LOO) essential oil in isolated guinea-pig trachea MATERIALS AND METHODS: Leaves from L. origanoides were collected at experimental fields under organic cultivation, at the Forest Garden of Universidade Estadual de Feira de Santana...
March 30, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29606967/effects-of-oregano-essential-oil-on-brain-tlr4-and-tlr2-gene-expression-and-depressive-like-behavior-in-a-rat-model
#19
Azam Amiresmaeili, Samira Roohollahi, Ali Mostafavi, Nayere Askari
The aim of the present study was to evaluate the effects of oregano essential oil (OEO) on the hippocampus and prefrontal cortex TLR 2/4 gene expression and depressive like behavior induced by chronic unpredictable stress (CUS). Sucrose preference and forced swim tests were adopted to examine the antidepressant effect. Control (CON), OEO, CUS, and CUS + OEO groups were used. The OEO and CUS + OEO groups received OEO (0.2 mL/kg, i.p.), CON and CUS received saline (0.2 mL/kg, i.p.), and the positive drug groups of CUS rats received fluoxetine (10 mg/kg) and diazepam (3 mg/kg) once daily for 14 days...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29600750/terpenes-phenylpropanoids-sulfur-and-other-essential-oil-constituents-as-inhibitors-of-cholinesterases
#20
Olivera Politeo, Franko Burcul, Ivica Blazevic, Mila Radan
Essential oils constituents are a diverse family of low molecular weight organic compounds with comprehensive biological activity. According to their chemical structure these active compounds can be divided into four major groups: terpenes, terpenoids, phenylpropenes, and "others". In addition, they may contain diverse functional groups according to which they can be classified as hydrocarbons (monoterpenes, sesquiterpenes, and aliphatic hydrocarbons); oxygenated compounds (monoterpene and sesquiterpene alcohols, aldehydes, ketones, esters, and other oxygenated compounds); and sulfur and/or nitrogen sulfur-containing compounds (thioesters, sulfides, isothiocyantes, nitriles, and others)...
March 29, 2018: Current Medicinal Chemistry
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