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https://www.readbyqxmd.com/read/29355155/blast-effect-of-shotgun-injury-in-kidney-mimicking-avulsion-of-the-low-pole
#1
Selahattin Caliskan, Musa Türkmen
No abstract text is available yet for this article.
September 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29354373/assessment-of-three-plastid-dna-barcode-markers-for-identification-of-clinacanthus-nutans-acanthaceae
#2
Noor Zafirah Ismail, Hasni Arsad, Mohammed Razip Samian, Mohammad Razak Hamdan, Ahmad Sofiman Othman
This study was conducted to determine the feasibility of using three plastid DNA regions (matK, trnH-psbA, and rbcL) as DNA barcodes to identify the medicinal plant Clinacanthus nutans. In this study, C. nutans was collected at several different locations. Total genomic DNA was extracted, amplified by polymerase chain reaction (PCR), and sequenced using matK, trnH-psbA, and rbcL, primers. DNA sequences generated from PCR were submitted to the National Center for Biotechnology Information's (NCBI) GenBank. Identification of C...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29353929/first-report-of-cactodera-estonica-in-canada
#3
Qing Yu, Fengcheng Sun
A population of cyst nematode with terminal protuberance was found in soil samples associated with and on the roots of Polygonum aviculare L. at N45°23.480', W75°40.463' in South Ottawa, Ontario. Both J2 and cysts were found. It was subsequently confirmed with morphological and molecular methods as Cactodera estonica Krall and Krall, 1978 (Krall and Krall, 1978). The cysts are dark brown, elongated with length/breadth ratio more than 2, and vulval fenestra circumfenestrate 33 ± 4.1 (20-48) µm in diameter...
December 2017: Journal of Nematology
https://www.readbyqxmd.com/read/29353537/exposure-to-impulse-noise-at-explosives-company-a-case-study
#4
Aleksandra Kulik, Jolanta Malinowska-Borowska
Impulse noise encountered in workplaces is a threat to hearing. The aim of this study was to assess the occupational exposure to impulse noise produced by detonation of dynamite in the premises of an explosives company. Test points were located on the blast test area (inside and outside the bunker) and in work buildings across the site. Noise propagation measurement was performed during 130 blast tests in 9 measurement points. At every point, at least 10 separate measurements of equivalent A-weighted sound pressure levels (LAeq), maximum A-weighted sound pressure level (LAmax), and C-weighted peak sound pressure level (LCpeak) were made...
January 22, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29351983/partial-tandem-duplication-of-kmt2a-mll-may-predict-a-subset-of-myelodysplastic-syndrome-with-unique-characteristics-and-poor-outcome
#5
Sarah M Choi, Rajan Dewar, Patrick W Burke, Lina Shao
Partial tandem duplication (PTD) of the KMT2A (MLL) gene is a poor prognostic factor in acute myeloid leukemia, but its significance in the context of myelodysplastic syndrome (MDS) is unknown. Here, we used cytogenomic array to identify MLL-PTD in a group of MDS patients and compared their clinicopathologic characteristics with a cohort of high-risk MDS patients without MLL-PTD. We show that MLL-PTD defines a subset of MDS characterized by high blast count, normal karyotype, and extremely poor prognosis exceeding that of non-MLL-PTD high risk MDS, including those with complex karyotype...
January 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29351734/eogd-the-euplotes-octocarinatus-genome-database
#6
Ruan-Lin Wang, Wei Miao, Wei Wang, Jie Xiong, Ai-Hua Liang
BACKGROUND: Euplotes, a ciliated protozoan, is a useful unicellular model organism. Studies on Euplotes have provided excellent insights into various basic biological principles. We have recently sequenced the macronuclear genome of the common freshwater species Euplotes octocarinatus to provide novel insights into Euplotes genetics and molecular biology. RESULTS: In this study, we present the E. octocarinatus Genome Database (EOGD), a functional annotation and analysis platform for the global study of the Euplotes genome...
January 19, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29351317/hafts-are-novel-lncrna-transcripts-from-aflatoxin-exposure
#7
B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expressed transcripts, several novel, unannotated Cufflinks-assembled transcripts, or HAfTs (Hepatic Aflatoxin Transcripts) were found. We hypothesized PCR-cloning and RACE (rapid amplification of cDNA ends) could further HAfT identification. Sanger data was obtained for 6 transcripts by PCR and 16 transcripts by 5'- and 3'-RACE...
2018: PloS One
https://www.readbyqxmd.com/read/29351059/nematode-thelazia-callipaeda-is-spreading-across-europe-the-first-survey-of-red-foxes-from-slovakia
#8
Viktória Čabanová, Martina Miterpáková, Martin Oravec, Zuzana Hurníková, Slavomír Jerg, Gabriela Nemčíková, Michaela Brincko Červenská
Canine thalaziosis caused by the spirurid nematode Thelazia callipaeda has started to spread across Western and Central Europe during the last decade. In Slovakia, the first autochthonous cases of this infection were recorded in 2016 in four dogs from the south-eastern part of the country. In August 2017 other autochthonous case, again from the same locality, was reported. Seeing that red foxes are considered the main reservoir hosts for T. callipaeda, their examination could provide an integrated view of the real parasite distribution...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29350080/irf2bp2-rara-t-1-17-q42-3-q21-2-apl-blasts-differentiate-in-response-to-all-trans-retinoic-acid
#9
Samir Mazharuddin, Anuja Chattopadhyay, Moshe Y Levy, Robert L Redner
No abstract text is available yet for this article.
January 19, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29348128/pevonedistat-a-first-in-class-nedd8-activating-enzyme-nae-inhibitor-combined-with-azacitidine-in-patients-with-aml
#10
Ronan T Swords, Steven Coutre, Michael B Maris, Joshua F Zeidner, James M Foran, Jose Cruz, Harry P Erba, Jesus G Berdeja, Wayne Tam, Saran Vardhanabhuti, Iwona Pawlikowska-Dobler, Hélène M Faessel, Ajeeta B Dash, Farhad Sedarati, Bruce J Dezube, Douglas V Faller, Michael R Savona
Pevonedistat (TAK-924/MLN4924) is a novel inhibitor of NEDD8-activating enzyme (NAE) with single-agent activity in relapsed/refractory acute myeloid leukemia (AML). We performed a phase 1b study (NCT01814826) of pevonedistat (PEV) with azacitidine (AZA) based on synergistic activity seen preclinically. Primary objectives included safety and tolerability, and secondary objectives included pharmacokinetics (PK) and disease response. Patients ≥60 years with treatment-naïve AML, unfit for standard induction therapy, received PEV 20 or 30 mg/m2 IV on days 1, 3, and 5, combined with fixed-dose AZA (75 mg/m2 IV/SC) on days 1-5, 8, and 9, every 28 days...
January 18, 2018: Blood
https://www.readbyqxmd.com/read/29346862/craters-produced-by-explosions-in-a-granular-medium
#11
F Pacheco-Vázquez, A Tacumá, J O Marston
We report on an experimental investigation of craters generated by explosions at the surface of a model granular bed. Following the initial blast, a pressure wave propagates through the bed, producing high-speed ejecta of grains and ultimately a crater. We analyzed the crater morphology in the context of large-scale explosions and other cratering processes. The process was analyzed in the context of large-scale explosions, and the crater morphology was compared with those resulting from other cratering processes in the same energy range...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346495/long-term-temporal-changes-in-structure-and-function-of-rat-visual-system-after-blast-exposure
#12
Daniel F Shedd, Nikolaus A Benko, Justin Jones, Brian E Zaugg, Robert L Peiffer, Brittany Coats
Purpose: We identify long-term ocular sequelae subsequent to experimental blast exposure. Methods: Male Long-Evans rats were exposed to 230 kPa side-on primary blast overpressure using a compressed air driven shock tube. Visual system function and structure were assessed for 8 weeks after exposure using optokinetic nystagmus and optical coherence tomography. Vitreous protein expression and histology (TUNEL, H&E) were performed at 1 day and 1, 4, and 8 weeks. IOP was recorded bilaterally during blast in a subset of animals...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29346478/differentiation-syndrome-associated-with-enasidenib-a-selective-inhibitor-of-mutant-isocitrate-dehydrogenase-2-analysis-of-a-phase-1-2-study
#13
Amir T Fathi, Courtney D DiNardo, Irina Kline, Laurie Kenvin, Ira Gupta, Eyal C Attar, Eytan M Stein, Stephane de Botton
Importance: Enasidenib mesylate, a mutant isocitrate dehydrogenase 2 (IDH2) protein inhibitor that promotes differentiation of leukemic myeloblasts, was recently approved by the US Food and Drug Administration for use in relapsed/refractory (R/R) mutant IDH2 acute myeloid leukemia (AML). During the first study of enasidenib in humans, a minority of patients with advanced myeloid neoplasms experienced unexpected signs/symptoms of a differentiation syndrome (DS), a potentially lethal entity...
January 18, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29345971/a-blast-from-the-past-back-to-the-1970s
#14
Philipp Dahm, Shahnaz Sultan, M Hassan Murad
No abstract text is available yet for this article.
January 18, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29344492/bilateral-hypopyon-uveitis-in-chronic-myeloid-leukemia
#15
Mudit Tyagi, Vishal Govindhari, Rajeev R Pappuru, Vikas Ambiya
Background: A leukemic hypopyon is considered an early sign of central nervous system involvement or systemic relapse. A differential diagnosis of masquerade syndromes should be considered in cases of hypopyon uveitis that are atypical or unresponsive to treatment. We report a case of a 45-year-old man who presented with bilateral hypopyon uveitis and was subsequently diagnosed as having chronic myeloid leukemia. Method: Retrospective case review. Results: A 45-year-old diabetic male presented with diminished vision in both eyes for 10 days...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344217/aleukemic-extramedullary-t-lymphoid-myeloid-bilineage-hematopoietic-and-lymphoid-malignancy-with-progression-to-bilineage-leukemia-at-relapse-a-case-report
#16
Mengyao Wu, Xiaoqiu Li, Feng Tang, Ping Zhu, Tianling Ding, Yan Yuan, Tong Chen
Bilineage T lymphoid and myeloid (T/My) neoplasms are rare entities among the hematopoietic and lymphoid malignancies. The majority of patients present with leukemic symptoms in which blasts are observed in the peripheral blood (PB) or bone marrow (BM) at a percentage of >20% of nucleated cells. Only a minimal number of cases of T/My bilineage hematopoietic and lymphoid malignancy have been reported with extramedullary infiltration as the initial symptom. The origin of the neoplastic cells in T/My bilineage malignancy has been documented as the hematopoietic stem cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344183/a-patient-with-chronic-myeloid-leukemia-and-situs-inversus-totalis-a-case-report
#17
Yunxia Sun, Xiaoli Li, Lijun Li, Huan Liu, Qian Xu, Bei Liu
In the present study, a case of chronic myeloid leukemia (CML) with complete situs inversus in a 68-year-old female patient was reported. The patient presented with general weakness, abdominal distension and tenderness in the right hypochondrium. A chest X-ray revealed a right-sided heart. Ultrasonography revealed situs inversus totalis. A bone marrow smear demonstrated CML in the accelerated phase. Imatinib mesylate was subsequently administered; the patient stopped taking imatinib mesylate following discharge from the hospital...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343890/first-two-bilateral-hand-transplantations-in-india-part-2-technical-details
#18
Mohit Sharma, Subramania Iyer, P Kishore, Jimmy Mathew, Raghuveer Reddy, Janarthanan Ramu, Sundeep Vijayaraghavan, Abhijeet Wakure, S M Mali Chetan, Visakh Varma, Ashish Chaudhari, Swapnil Dhake, Akshay Omkumar, Jerry Paul, Sunil Rajan, Ayyappan Nair, Druvan Shaji
Introduction: This article deals with two patients who underwent bilateral hand transplantation following amputation of both upper limbs at the distal third of the foream. Materials and Methods: The first patient had a history of loss of hands in a train accident , with possiblity of a run over element during the injury. The second patient lost his both hands in a mine blast. The preoperative work up included detailed clinical and psychological evaluation. The donor retrieval was similar in both the cases and the donors were housed in our own instittution...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343273/inpp4b-promotes-cell-survival-via-sgk3-activation-in-npm1-mutated-leukemia
#19
Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing, Ling Zhang
BACKGROUND: Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification. The genetic events underlying oncogenesis in NPM1-mutated AML that is characterized by a normal karyotype remain unclear. Inositol polyphosphate 4-phosphatase type II (INPP4B), a new factor in the phosphoinositide-3 kinase (PI3K) pathway-associated cancers, has been recently found a clinically relevant role in AML...
January 17, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29343209/mild-blast-injury-produces-acute-changes-in-basal-intracellular-calcium-levels-and-activity-patterns-in-mouse-hippocampal-neurons
#20
Kyle R Hansen, Gloria J DeWalt, Ali I Mohammed, Hua-An Tseng, Moona E Abdulkerim, Seth Bensussen, Venkatesh Saligrama, Bobak Nazer, William D Eldred, Xue Han
Mild traumatic brain injury (mTBI) represents a serious public health concern. While much is understood about long term changes in cell signaling and anatomical pathologies associated with mTBI, little is known about acute changes in neuronal function. Using large scale Ca2+ imaging in vivo, we characterized the intracellular Ca2+ dynamics in thousands of individual hippocampal neurons using a repetitive mild blast injury model where blasts were directed onto the cranium of unanesthetized mice on two consecutive days...
January 17, 2018: Journal of Neurotrauma
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