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https://www.readbyqxmd.com/read/27368714/febrile-ulceronecrotic-mucha-habermann-disease-in-an-8-year-old-boy-responding-to-methotrexate
#1
Jehad Alratrout, Fatima Alshammasi, Naseem Ansari
BACKGROUND: Febrile ulceronecrotic Mucha-Habermann disease (FUMHD) is a rare fulminant variant of pityriasis lichenoides et varioliformis acuta (PLEVA) characterized by a rapidly progressive course with predominant ulceronecrotic lesions associated with fever and systemic manifestations. First described by Degos in 1966, it carries a high morbidity and is potentially fatal. The exact pathogenesis is not clear, but it is proposed to be the result of hypersensitivity reaction to an infection...
July 1, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27274548/pityriasis-lichenoides-chronica-presenting-with-bilateral-palmoplantar-involvement
#2
Lyubov Avshalumova, Blakely Richardson, Richard Miller
Pityriasis lichenoides is an uncommon, acquired, idiopathic, self-limiting skin disease that poses a challenge to patients and clinicians to diagnose and treat. Several variants exist including pityriasis lichenoides et varioliformis acuta (PLEVA), pityriasis lichenoides chronica (PLC), and febrile ulcer-onecrotic Mucha-Habermann disease. Precise classification can be difficult due to an overlap of clinical and histologic features. In this case report we describe a patient with a rare presentation of PLC exhibiting bilateral palmoplantar involvement and mimicking psoriasis...
May 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27088695/commentary-on-agreement-between-a-physical-therapist-and-an-orthopedic-surgeon-in-children-referred-for-gait-abnormalities
#3
COMMENT
Stacy Stolzman, Anne Pleva
No abstract text is available yet for this article.
2016: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/27069104/comparison-of-the-efficacy-of-paclitaxel-eluting-balloon-catheters-and-everolimus-eluting-stents-in-the-treatment-of-coronary-in-stent-restenosis-the-treatment-of-in-stent-restenosis-study
#4
Leos Pleva, Pavel Kukla, Pavlina Kusnierova, Jana Zapletalova, Ota Hlinomaz
BACKGROUND: The aim of this prospective randomized noninferiority study was to compare the efficacy of paclitaxel-eluting balloon (PEB) catheters and everolimus-eluting stents (EES) in the treatment of bare metal stent restenosis. METHODS AND RESULTS: A total of 136 patients were enrolled in the study. Each treatment group included 68 patients with 74 in-stent restenotic lesions. The primary end point was in-segment late lumen loss (LLL) at 12 months. Secondary end points were the incidence of binary in-stent restenosis and 12-month major adverse cardiac events...
April 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/26584702/febrile-ulceronecrotic-mucha-habermann-disease-two-cases-with-excellent-response-to-methotrexate
#5
Kelly Griffith-Bauer, Sabra L Leitenberger, Alfons Krol
Febrile ulceronecrotic Mucha-Habermann disease (FUMHD), a severe form of pityriasis lichenoides et varioliformis acuta (PLEVA), featuring large, ulcerative, necrotic skin plaques, high fever, and other systemic symptoms, is a rare disorder of unknown etiology. No randomized controlled trials have established treatment guidelines and multiple modalities are often employed, making it difficult to assess the efficacy of any single agent. We report two cases of this condition in which treatment with methotrexate plus antibiotic treatment for superinfection led to rapid improvement...
November 2015: Pediatric Dermatology
https://www.readbyqxmd.com/read/26552626/-febrile-ulceronecrotic-mucha-habermann-disease
#6
A Dupin, D Bosset, L Atger, B Chevallier, P Saiag, G Benoist
Pityriasis lichenoides et varioliformis acuta (PLEVA) is an inflammatory skin disease that is unknown to pediatricians. The ulceronecrotic febrile form is a rare and potentially lethal variant. We report the case of a 7-year-old boy with a papulovesicular eruption lasting for 4 weeks, secondarily associated with ulcers and necrotic crusts, fever, and systemic signs. After exploring infectious causes such as chickenpox, we discussed and confirmed PLEVA with histological analysis. Systemic steroids and methotrexate improved the symptoms...
January 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26365933/increased-levels-of-mmp-3-mmp-9-and-mpo-represent-predictors-of-in-stent-restenosis-while-increased-levels-of-adma-lcat-apoe-and-apod-predict-bare-metal-stent-patency
#7
Leos Pleva, Pavlina Kusnierova, Pavlina Plevova, Jana Zapletalova, Michal Karpisek, Lucie Faldynova, Petra Kovarova, Pavel Kukla
AIMS: We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting. METHODS: A total of 111 consecutive patients with post-percutaneous coronary intervention (PCI) in-stent restenosis of a target lesion within 12 months were matched for age, sex, vessel diameter, and diabetes with 111 controls without post-PCI ISR. Plasma or serum levels of biochemical markers were measured: matrix metalloproteinases (MMP) 2, 3, 9; myeloperoxidase (MPO); asymmetric dimethylarginine (ADMA); lipoprotein (a) (Lp[a]); apolipoproteins E and D (ApoE and D); and lecitin-cholesterol acyltransferase (LCAT)...
December 2015: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/26263922/atypical-cutaneous-%C3%AE-%C3%AE-t-cell-proliferation-with-morphologic-features-of-lymphoma-but-with-clinical-features-and-course-of-pleva-or-lymphomatoid-papulosis
#8
Rebecca L King, Albert C Yan, Debora R Sekiguchi, John K Choi
Reactive lymphoid infiltrates of the skin composed predominantly of gamma-delta (γδ) T cells are not well described in the literature. Herein we report a case of an otherwise healthy 4-year-old male who presented with a waxing and waning papular rash characterized by small, discrete crusted papules spread across his trunk, face and extremities. Clinical evaluation revealed no evidence of systemic disease. Microscopic examination revealed a dermal, perivascular infiltrate of highly atypical lymphocytes with a γδ T cell phenotype, worrisome for primary cutaneous γδ T cell lymphoma...
August 12, 2015: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/26235693/-pityriasis-lichenoides-case-report-and-review-of-the-literature
#9
María Soledad T Zegpi, Felipe M Ruiz, Ninoska K Porras
INTRODUCTION: Pityriasis lichenoides is a benign inflammatory disease of unknown etiology. There are two types of this condition: an acute form (PLEVA = pityriasis lichenoides et varioliformis acuta) and a chronic one (PLC = pityriasis lichenoid chronica). Both are more common in children and young adults. OBJECTIVE: To describe a case of PLC, discuss its clinical presentation, diagnosis, treatment and present a review of the literature. CASE REPORT: A seven-year-old child who presented with recurrent oligosymptomatic episodes of bright erythematous papular lesions in centripetal distribution, which subsided and left behind hypopigmented macules...
March 2015: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/26151887/reference-intervals-of-plasma-matrix-metalloproteinases-2-3-and-9-and-serum-asymmetric-dimethylarginine-levels
#10
Pavlina Kusnierova, Frantisek Vsiansky, Leos Pleva, Pavlina Plevova, Kristian Safarcik, Zdenek Svagera
OBJECTIVE: The present study aimed to verify the reference intervals of plasma matrix metalloproteinases (MMPs) 2, 3, and 9 and serum asymmetric dimethylarginine (ADMA) in a healthy population with an average age corresponding to that of patients with cardiovascular diseases. METHODS: The study included 180 healthy volunteers. Plasma MMP-2, MMP-3, MMP-9, and serum ADMA levels were determined using an enzyme-linked immunosorbent assay. These levels were analyzed for association with age and gender...
October 2015: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/25816855/pityriasis-lichenoides-in-childhood-review-of-clinical-presentation-and-treatment-options
#11
REVIEW
Lauren Geller, Nina K Antonov, Christine T Lauren, Kimberly D Morel, Maria C Garzon
Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children...
September 2015: Pediatric Dermatology
https://www.readbyqxmd.com/read/25655620/impact-of-an-intravenous-magnesium-shortage-on-potassium-doses-in-adult-surgical-patients-receiving-parenteral-nutrition
#12
Lisa A Scherkenbach, Michael D Kraft, Stephen M Stout, Michael P Dorsch, Xinwei Chen, Hong-Diem Tran, Melissa R Pleva
BACKGROUND: Shortages of parenteral nutrition (PN) components have been common in recent years. Effects on patient management and outcomes have not been well documented. This study aimed to determine the effect of a parenteral magnesium shortage, and an institutional decision to omit magnesium from adult PN, on magnesium and potassium doses and serum concentrations. MATERIALS AND METHODS: This was a retrospective cohort study of adult surgical patients during two 6-month periods: prior to the magnesium shortage (2011) and during the shortage (2012)...
July 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/25580084/tissue-ischemia-microdialysis-assessments-following-severe-traumatic-haemorrhagic-shock-lactate-pyruvate-ratio-as-a-new-resuscitation-end-point
#13
Filip Burša, Leopold Pleva, Jan Máca, Peter Sklienka, Pavel Ševčík
BACKGROUND: Intensive care of severe trauma patients focuses on the treatment of haemorrhagic shock. Tissues should be perfused sufficiently with blood and with sufficient oxygen content to ensure adequate tissue oxygen delivery. Tissue metabolism can be monitored by microdialysis, and the lactate/pyruvate ratio (LPR) may be used as a tissue ischemia marker. The aim of this study was to determine the adequate cardiac output and haemoglobin levels that avoid tissue ischemia. METHODS: Adult patients with serious traumatic haemorrhagic shock were enrolled in this prospective observational study...
2014: BMC Anesthesiology
https://www.readbyqxmd.com/read/25050528/left-atrium-assessment-the-evolving-role-of-mri
#14
REVIEW
Roman Panovsky, Martin Pleva, Vera Feitova, Peter Kruzliak, Jaroslav Meluzin, Vladimir Kincl, Petr Novotny, Jiri Vanicek
The left atrium plays an integral role in cardiac performance. Data regarding the left atrial size, volume, function, and structure are clinically important in the management of patients with different diagnoses. Moreover, left atrial size and function were recognized as robust predictors of poor outcome across a broad range of cardiac diseases. These data are usually obtained using echocardiography. MRI can be used as an alternative tool or in clinical or experimental situations when more exact and detailed assessment is required...
October 2015: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/24891247/-multiple-trauma-treatment-of-skeletal-injuries-with-damage-control-orthopaedics
#15
M Sír, L Pleva, V Procházka
New methods of treating seriously injured patients have been introduced in the field of trauma surgery since 1993. These consist mostly of differentiated and rapid procedures of treatment of the injured skeleton, with the aim of preventing the development of severe haemorrhagic shock and exsanguination of the patient. The precondition for introducing these techniques is the study of the organisms inflammatory response to trauma. Since 2000, this approach has been called damage control orthopaedics. The authors deal with the history of this method, the physiology of severe trauma, selection of patients eligible for this method and the appropriate timing of definitive treatment...
May 2014: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/24699110/the-prognostic-impact-of-myocardial-late-gadolinium-enhancement
#16
REVIEW
Roman Panovsky, Martin Pleva, Vera Feitova, Peter Kruzliak, Jaroslav Meluzin, Vladimir Kincl
Cardiovascular magnetic resonance using late gadolinium enhancement (LGE) provides a unique opportunity to assess myocardial tissue in vivo. LGE enables tissue characterization in ischemic and nonischemic cardiomyopathies and other cardiac diseases. LGE is associated with adverse clinical outcomes across a range of different cardiac conditions and may improve risk stratification for death, sudden cardiac death, or serious adverse events beyond traditional prognostic markers. Generally, matching data for the prognostic impact of LGE are frequently reached in cardiac disorders...
May 2014: Cardiology in Review
https://www.readbyqxmd.com/read/24499479/anaerobic-metabolism-associated-with-traumatic-hemorrhagic-shock-monitored-by-microdialysis-of-muscle-tissue-is-dependent-on-the-levels-of-hemoglobin-and-central-venous-oxygen-saturation-a-prospective-observational-study
#17
Filip Burša, Leopold Pleva
BACKGROUND: Traumatic hemorrhagic shock resulting in tissue hypoxia is a significant cause of morbidity and mortality in polytraumatized patients. Early identification of tissue hypoxia is possible with microdialysis. The aim of this study was to determine the correlation between a marker of tissue hypoxia (L/P; lactate to pyruvate ratio) and selected parameters of systemic oxygen delivery (Hb; hemoglobin) and oxygen extraction (ScvO2; central venous oxygen saturation). We also investigated the severity of tissue hypoxia over the course of care...
2014: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/24438143/epstein-barr-virus-associated-t-natural-killer-cell-lymphomas-in-the-elderly-the-first-consensus-meeting-in-kofu-2013
#18
Toshihisa Hamada, Shigeo Nakamura, Young-Hyeh Ko, Tadashi Yoshino, Koichi Ohshima, Takamitsu Matsuzawa, Keiko Miura, Toshifumi Takahashi, Hisashi Nomura, Tomomi Hoshino, Daisuke Suzuki, Shinji Shimada, Keiji Iwatsuki
From a clinicopathological conference on nine elderly patients with Epstein-Barr virus (EBV)-associated T/natural killer (NK)-cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T-cell lymphoma, nasal type (ENKL) with an NK-cell phenotype, and two patients had EBV(+) T-cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV)...
January 2014: Journal of Dermatology
https://www.readbyqxmd.com/read/24323468/pharmacokinetics-of-ertapenem-in-critically-ill-patients-receiving-continuous-venovenous-hemodialysis-or-hemodiafiltration
#19
Rachel F Eyler, A Mary Vilay, Ahmed M Nader, Michael Heung, Melissa Pleva, Kevin M Sowinski, Daryl D DePestel, Fritz Sörgel, Martina Kinzig, Bruce A Mueller
This study characterizes the pharmacokinetics of ertapenem, a carbapenem antibiotic, in critically ill adult subjects receiving continuous renal replacement therapy (CRRT). Eight critically ill patients with suspected/known Gram-negative infections receiving continuous venovenous hemodialysis (CVVHD) or continuous venovenous hemodiafiltration (CVVHDF) and ertapenem were enrolled. One gram of ertapenem was infused over 30 min. Predialyzer blood samples were drawn with the first dose of ertapenem from the hemodialysis tubing at time zero, 30 min, and 1, 2, 4, 8, 12, 18, and 24 h after the start of the ertapenem infusion...
2014: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/24282656/the-relevance-of-recognizing-clinical-and-morphologic-features-of-pityriasis-lichenoides-clinicopathological-study-of-29-cases
#20
Jandrei Rogério Markus, Vânia Oliveira Carvalho, Monica Nunes Lima, Kerstin Taniguchi Abagge, Alexandre Nascimento, Betina Werner
BACKGROUND: Pityriasis lichenoides (PL) is a lymphoproliferative disease of unknown origin; its diagnosis is based on clinical characteristics and confirmed by histology. OBJECTIVES: To describe clinical and histological features of PL in 29 pediatric patients. MATERIALS AND METHODS: Retrospective descriptive study of children (patients less than 15 years old) diagnosed with PL between 1986 and 2010 at a Reference Service in Pediatric Dermatology from South Brazil...
2013: Dermatology Practical & Conceptual
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