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Phosphate food

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https://www.readbyqxmd.com/read/29148163/development-and-validation-of-a-high-performance-liquid-chromatography-method-for-determination-of-lisinopril-in-human-plasma-by-magnetic-solid-phase-extraction-and-pre-column-derivatization
#1
Noushin Rastkari, Reza Ahmadkhaniha
A sensitive, reliable and simple HPLC method was developed for the determination of lisinopril in human plasma. The method consists of extraction and clean-up steps based on magnetic solid-phase extraction and pre-column derivatization with a fluorescent reagent. The mobile phase consisted of a mixture of methanol-sodium dihydrogen phosphate (pH 3.0; 0.005 m; 75:25, v/v). The flow rate was set at 0.7 mL/min. Fluorescence detection was performed at 470nm excitation and 530nm emission wavelengths. Total chromatography run time was 5 min...
November 16, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29148025/a-3-day-diary-of-dietary-protein-and-calorie-intake-by-serum-phosphate-concentration-and-binder-use-in-hemodialysis-patients
#2
Meiry J S Araújo, Luciana F Silva, Maria T S Martins, Cacia M Matos, Marcelo B Lopes, Rilma F S Santos, LarissaS Santos, Angiolina C Kraychete, Márcia T S Martins, Fernanda A Silva, Antonio A Lopes
INTRODUCTION: The use of phosphate binders to control hyperphosphatemia may allow diets less restricted in protein and calories for maintenance hemodialysis (MHD) patients. The study compared intakes of protein, calorie and phosphate among MHD patients with different serum phosphate concentrations, taking into account binder use. The hypothesis was that low serum phosphate would be associated with low intakes of protein and calories only in patients not on binders. METHODS: A cross-sectional study of 443 patients enrolled in the Prospective Study of the Prognosis of Chronic Hemodialysis Patients (PROHEMO) in Salvador, Brazil, with stratified sampling on serum phosphate: ≤3...
November 4, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29144406/evaluating-differences-in-aluminum-exposure-through-parenteral-nutrition-in-neonatal-morbidities
#3
Megan Fortenberry, Lela Hernandez, Jacob Morton
Aluminum is a common contaminant in many components of parenteral nutrition, especially calcium and phosphate additives. Although long-term effects have been described in the literature, short-term effects are not well-known. Currently, the Food and Drug Administration recommends maintaining aluminum at <5 mcg/kg/day. This was a single center, retrospective case-control study of 102 neonatal intensive care unit patients. Patients were included if they had a diagnosis of necrotizing enterocolitis, rickets/osteopenia, or seizures and received at least 14 days of parenteral nutrition...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29142410/methanolic-extract-of-costus-pictus-d-don-induces-cytotoxicity-in-liver-hepatocellular-carcinoma-cells-mediated-by-histone-deacetylase-inhibition
#4
P V Neethu, K Suthindhiran, M A Jayasri
Background: Leaves of Costus pictus D. Don, (insulin plant) are used as dietary supplement for the treatment of diabetes. Objective: The antidiabetic activity of this plant is well documented, but its activity on different cell types and mechanism remains unknown. Thus, the present study evaluates the cytotoxicity of C. pictus methanolic extract (CPME) against various cancer and normal cells. Materials and Methods: Dried leaves of C. pictus were extracted using methanol and were subjected to histone deacetylase (HDAC) inhibition and toxicity studies...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142398/cytotoxic-antimitotic-and-antiproliferation-studies-on-rasam-a-south-indian-traditional-functional-food
#5
Agilandeswari Devarajan, M K Mohan Maruga Raja
Background: Rasam is a traditional South Indian food, prepared using tamarind juice as a base, with a variety of spices. Rasam, with all its ingredients medicinally claimed for various ailments, is a functional food. Systematic consumption of traditional functional food provides an excellent preventive measure to ward off many diseases. Objective: To study rasam for cytotoxic, antimitotic, and antiproliferation potential beyond its culinary and nutritional effect...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137730/the-influence-of-bovine-serum-albumin-modified-silica-on-the-physicochemical-properties-of-poly-vinyl-alcohol-nanocomposites-synthesized-by-ultrasonication-technique
#6
Shadpour Mallakpour, Hossein Yazdan Nazari
In this study, for the first time polymeric nanocomposite (NC) films of poly(vinyl alcohol)/SiO2@bovine serum albumin (PVA/SiO2@BSA) were synthesized by solution casting method under facile and fast method of sonication. In this regard, SiO2 nanoparticles (NPs) were modified by BSA, at room temperature by using phosphate buffer and ultrasonic-assisted method. Then, PVA/SiO2@BSA NCs were prepared by insertion of variant amount (3, 6 and 9wt%) of SiO2@BSA into the PVA matrix, under ultrasonic irradiation. The morphological traits of the NCs were surveyed by Fourier transform infrared spectroscopy, transmission electron microscopy, X-ray diffraction and field emission scanning electron microscopy...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136806/multivariate-analysis-of-organic-acids-in-fermented-food-from-reversed-phase-high-performance-liquid-chromatography-data
#7
Pablo Mortera, Federico A Zuljan, Christian Magni, Santiago A Bortolato, Sergio H Alarcón
Multivariate calibration coupled to RP-HPLC with diode array detection (HPLC-DAD) was applied to the identification and the quantitative evaluation of the short chain organic acids (malic, oxalic, formic, lactic, acetic, citric, pyruvic, succinic, tartaric, propionic and α-cetoglutaric) in fermented food. The goal of the present study was to get the successful resolution of a system in the combined occurrence of strongly coeluting peaks, of distortions in the time sensors among chromatograms, and of the presence of unexpected compounds not included in the calibration step...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29126994/a-dual-promoter-gene-orchestrates-the-sucrose-coordinated-synthesis-of-starch-and-fructan
#8
Yunkai Jin, Mingliang Fei, Sara Rosenquist, Lu Jin, Suresh Gohil, Corine Sandström, Helena Olsson, Cecilia Persson, Anna-Stina Höglund, Gunnel Fransson, Ying Ruan, Per Åman, Christer Jansson, Chunlin Liu, Roger Andersson, Chuanxin Sun
Sequential carbohydrate synthesis is important for plant survival because it guarantees energy supplies for growth and development during plant ontogeny and reproduction. Starch and fructan are two important carbohydrates in many flowering plants and in human diets. Understanding this coordinated starch and fructan synthesis and unravelling how plants allocate photosynthates and prioritize different carbohydrate synthesis for survival could lead to improvements to cereals in agriculture for the purposes of greater food security and production quality...
November 7, 2017: Molecular Plant
https://www.readbyqxmd.com/read/29125718/effects-of-high-and-low-fat-meals-on-the-pharmacokinetics-of-ozanimod-a-novel-sphingosine-1-phosphate-receptor-modulator
#9
Jonathan Q Tran, Jeffrey P Hartung, Cindy-Ann Tompkins, Paul A Frohna
Ozanimod (RPC1063) is an oral selective modulator of the sphingosine-1-phosphate 1 and 5 receptors under development for the treatment of relapsing multiple sclerosis and inflammatory bowel disease. The effects of high-fat and low-fat meals on the pharmacokinetics (PK) of a single oral dose of ozanimod were evaluated in 24 healthy volunteers in a randomized, open-label crossover trial. Each subject received a 1-mg dose of ozanimod hydrochloride under 3 meal conditions (fasted, high-fat, and low-fat), each separated by 7 days...
November 10, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29125000/salivary-evaluation-in-radioactive-i-131-treated-patients-with-thyroid-carcinoma
#10
Filipe Ivan Daniel, Luiza Dutra Lima, Liliane Janete Grando, Renata Castro, Elke Annegret K Cordeiro, Claudia Regina Dos Santos
BACKGROUND AND OBJECTIVE: radioiodine treatment (I(131)) used to treat thyroid carcinomas produces side effects (sialadenitis, xerostomia, dysphagia and caries susceptibility) reflecting in a poor patient quality of life. This study aimed to evaluate the effect of I(131) on salivary function and possible oral impairment. MATERIAL AND METHODS: Thirty-seven patients undergoing I(131) were submitted to oral examination, answer questions regarding xerostomia/hyposalivation and collect saliva at three moments (M1: 30-45 days before I(131), M2: 1-2 days after I(131) and M3: 7-10 days after treatment)...
November 10, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29119383/determination-of-trace-metal-concentration-in-compost-dap-and-tsp-fertilizers-by-neutron-activation-analysis-naa-and-insights-from-density-functional-theory-calculations
#11
Md Sajjadur Rahman, Syed Mohammod Hossain, Mir Tamzid Rahman, Mohammad A Halim, Mohammad Niaz Ishtiak, Mahbub Kabir
Leaching of toxic metals from fertilizers is a growing concern in an agricultural country like Bangladesh due to the serious consequences in health and food chain. Fertilizers used in farming fields and nurseries (plant sales outlet) in the mid-southern part of Bangladesh were collected for the determination of toxic metals. This study employed the neutron activation method and a relative standardization approach. Three standard/certified reference materials, namely NIST coal fly ash 1633b, IAEA-Soil-7, and IAEA-SL-1 (lake sediment), were considered for elemental quantification...
November 8, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29112739/organophosphate-flame-retardants-alter-adult-mouse-homeostasis-and-gene-expression-in-a-sex-dependent-manner-potentially-through-interactions-with-er%C3%AE
#12
Elizabeth A Krumm, Vipa J Patel, Taylor S Tillery, Ali Yasrebi, Jianliang Shen, Grace L Guo, Stephanie M Marco, Brian T Buckley, Troy A Roepke
Flame retardants (FR) such as polybrominated diphenyl ethers (PBDE) and organophosphate FR (OPFR) persist in the environment and interact with multiple nuclear receptors involved in homeostasis, including estrogen receptors (ER). However, little is known about the effects of FR, especially OPFR, on mammalian neuroendocrine functions. Therefore, we investigated if exposure to FR alters hypothalamic gene expression and whole-animal physiology in adult wild-type (WT) and ERα KO mice. Intact WT and KO males and ovariectomized WT and KO females were orally dosed daily with vehicle (oil), 17α-ethynylestradiol (2...
November 3, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29111888/stability-of-don-and-don-3-glucoside-during-baking-as-affected-by-the-presence-of-food-additives
#13
Arnau Vidal, Vicente Sanchis, Antonio J Ramos, Sonia Marín
The mycotoxin deoxynivalenol (DON) is one of the most common mycotoxins of cereals worldwide, and its occurrence has been widely reported in raw wheat. The free mycotoxin form is not the only route of exposure; modified forms can also be present in cereal products. Deoxynivalenol-3-glucoside (DON-3-glucoside) is a common DON plant conjugate. The mycotoxin concentration could be affected by food processing; here, we studied the stability of DON and DON-3-glucoside during baking of small doughs made from white wheat flour and other ingredients...
November 7, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29111855/neuroprotective-effects-of-inhibitors-of-acid-sensing-ion-channels-asics-in-optic-nerve-crush-model-in-rodents
#14
Dorota L Stankowska, Brett H Mueller, Hidehiro Oku, Tsunehiko Ikeda, Adnan Dibas
PURPOSE: The purpose of the current study was to assess the potential involvement of acid-sensing ion channel 1 (ASIC1) in retinal ganglion cell (RGC) death and investigate the neuroprotective effects of inhibitors of ASICs in promoting RGC survival following optic nerve crush (ONC). RESULTS: ASIC1 protein was significantly increased in optic nerve extracts at day 7 following ONC in rats. Activated calpain-1 increased at 2 and 7 days following ONC as evidenced by increased degradation of α-fodrin, known substrate of calpain...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29101780/thyroid-disrupting-effects-of-halogenated-and-next-generation-chemicals-on-the-swim-bladder-development-of-zebrafish
#15
Amy Godfrey, Blair Hooser, Ahmed Abdelmoneim, Katharine A Horzmann, Jennifer L Freemanc, Maria S Sepúlveda
Endocrine disrupting chemicals (EDCs) can alter thyroid function and adversely affect growth and development. Halogenated compounds, such as perfluorinated chemicals commonly used in food packaging, and brominated flame retardants used in a broad range of products from clothing to electronics, can act as thyroid disruptors. Due to the adverse effects of these compounds, there is a need for the development of safer next generation chemicals. The objective of this study was to test the thyroid disruption potential of old use and next generation halogenated chemicals...
October 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29095161/structure-and-function-of-the-thermostable-l-asparaginase-from-thermococcus-kodakarensis
#16
Jingxu Guo, Alun R Coker, Steve P Wood, Jonathan B Cooper, Shahid Mahmood Chohan, Naeem Rashid, Muhummad Akhtar
L-Asparaginases catalyse the hydrolysis of asparagine to aspartic acid and ammonia. In addition, L-asparaginase is involved in the biosynthesis of amino acids such as lysine, methionine and threonine. These enzymes have been used as chemotherapeutic agents for the treatment of acute lymphoblastic leukaemia and other haematopoietic malignancies since the tumour cells cannot synthesize sufficient L-asparagine and are thus killed by deprivation of this amino acid. L-Asparaginases are also used in the food industry and have potential in the development of biosensors, for example for asparagine levels in leukaemia...
November 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/29083435/dairy-intakes-in-older-irish-adults-and-effects-on-vitamin-micronutrient-status-data-from-the-tuda-study
#17
E Laird, M C Casey, M Ward, L Hoey, C F Hughes, K McCarroll, C Cunningham, J J Strain, H McNulty, A M Molloy
BACKGROUND: Consumption of dairy products has been associated with positive health outcomes including a lower risk of hypertension, improved bone health and a reduction in the risk of type 2 diabetes. The suggested dairy intake for health in older adults is three servings per day but recent analysis of the NHANES data for older adults reported 98% were not meeting these recommendations. No studies have investigated the consequences of such declines in the dairy intakes of Irish older adults and the subsequent effects on vitamin micronutrient status...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29070807/functional%C3%A2-characterization-of-the-pht1-family-transporters-of-foxtail-millet-with-development-of-a-novel-agrobacterium-mediated-transformation-procedure
#18
S Antony Ceasar, Alison Baker, S Ignacimuthu
Phosphate is an essential nutrient for plant growth and is acquired from the environment and distributed within the plant in part through the action of phosphate transporters of the PHT1 family. Foxtail millet (Setaria italica) is an orphan crop essential to the food security of many small farmers in Asia and Africa and is a model system for other millets. A novel Agrobacterium-mediated transformation and direct plant regeneration procedure was developed from shoot apex explants and used to downregulate expression of 3 members of the PHT1 phosphate transporter family SiPHT1;2 SiPHT1;3 and SiPHT1;4...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29068210/direct-conversion-of-co2-to-%C3%AE-farnesene-using-metabolically-engineered-synechococcus-elongatus-pcc-7942
#19
Hyun Jeong Lee, Jiwon Lee, Sun-Mi Lee, Youngsoon Um, Yunje Kim, Sang Jun Sim, Jong-Il Choi, Han Min Woo
Direct conversion of carbon dioxide (CO2) to value-added chemicals by engineering of cyanobacteria has received attention as a sustainable strategy in food and chemical industries. Herein, Synechococcus elongatus PCC 7942, a model cyanobacterium, was engineered to produce α-farnesene from CO2. Due to the lack of farnesene synthase (FS) activity in the wild-type cyanobacterium, we metabolically engineered S. elongatus PCC 7942 to express heterologous FS from either Norway spruce or apple fruit, resulting in detectable peaks of α-farnesene...
October 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29064180/a-service-review-to-assess-if-innovative-intensive-phosphate-dietary-education-can-help-reduce-phosphate-levels-to-the-recommended-range-in-a-hemodialysis-population
#20
Eileen A Duff, Fiona M Chawke
INTRODUCTION: Studies suggest that hemodialysis (HD) patients are less likely to adhere to phosphate dietary restriction than to potassium, sodium, or fluid restriction. It is particularly important that dietary education is provided appropriately, consistently, and reinforced regularly to encourage compliance with diet and phosphate-binder regimens. Patient awareness of the consequences of a chronically raised phosphate and its treatment is associated with lower serum phosphate levels...
October 2017: Hemodialysis International
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