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https://www.readbyqxmd.com/read/29768437/oral-health-status-in-historic-population-macroscopic-and-metagenomic-evidence
#1
Claire Willmann, Xavier Mata, Kristian Hanghoej, Laure Tonasso, Lenka Tisseyre, Céline Jeziorski, Elodie Cabot, Pierre Chevet, Eric Crubézy, Ludovic Orlando, Rémi Esclassan, Catherine Thèves
Recent developments in High-Throughput DNA sequencing (HTS) technologies and ancient DNA (aDNA) research have opened access to the characterization of the microbial communities within past populations. Most studies have, however, relied on the analysis of dental calculus as one particular material type particularly prone to the molecular preservation of ancient microbial biofilms and potential of entire teeth for microbial characterization, both of healthy communities and pathogens in ancient individuals, remains overlooked...
2018: PloS One
https://www.readbyqxmd.com/read/29767545/pharmacogenetics-of-novel-oral-anticoagulants-a-review-of-identified-gene-variants-future-perspectives
#2
Adna Ašić, Damir Marjanović, Jure Mirat, Dragan Primorac
Novel oral anticoagulants (NOACs) are becoming a therapy of choice in everyday clinical practice after almost 50 years during which warfarin and related coumarin derivatives were used as the main anticoagulants. Advantages of NOACs over standard anticoagulants include their predictable pharmacodynamics and pharmacokinetics, stable plasma concentrations and less drug-drug and food-drug interactions. However, pharmacogenetics has its place in administration of NOACs, as considerable interindividual variations have been detected...
May 16, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29719544/genome-sequencing-of-ancient-plant-remains-findings-uses-and-potential-applications-for-the-study-and-improvement-of-modern-crops
#3
REVIEW
Antimo Di Donato, Edgardo Filippone, Maria R Ercolano, Luigi Frusciante
The advent of new sequencing technologies is revolutionizing the studies of ancient DNA (aDNA). In the last 30 years, DNA extracted from the ancient remains of several plant species has been explored in small-scale studies, contributing to understand the adaptation, and migration patterns of important crops. More recently, NGS technologies applied on aDNA have opened up new avenues of research, allowing investigation of the domestication process on the whole-genome scale. Genomic approaches based on genome-wide and targeted sequencing have been shown to provide important information on crop evolution and on the history of agriculture...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29684051/estimating-genetic-kin-relationships-in-prehistoric-populations
#4
Jose Manuel Monroy Kuhn, Mattias Jakobsson, Torsten Günther
Archaeogenomic research has proven to be a valuable tool to trace migrations of historic and prehistoric individuals and groups, whereas relationships within a group or burial site have not been investigated to a large extent. Knowing the genetic kinship of historic and prehistoric individuals would give important insights into social structures of ancient and historic cultures. Most archaeogenetic research concerning kinship has been restricted to uniparental markers, while studies using genome-wide information were mainly focused on comparisons between populations...
2018: PloS One
https://www.readbyqxmd.com/read/29607044/ancient-pathogen-dna-in-human-teeth-and-petrous-bones
#5
Ashot Margaryan, Henrik B Hansen, Simon Rasmussen, Martin Sikora, Vyacheslav Moiseyev, Alexandr Khoklov, Andrey Epimakhov, Levon Yepiskoposyan, Aivar Kriiska, Liivi Varul, Lehti Saag, Niels Lynnerup, Eske Willerslev, Morten E Allentoft
Recent ancient DNA (aDNA) studies of human pathogens have provided invaluable insights into their evolutionary history and prevalence in space and time. Most of these studies were based on DNA extracted from teeth or postcranial bones. In contrast, no pathogen DNA has been reported from the petrous bone which has become the most desired skeletal element in ancient DNA research due to its high endogenous DNA content. To compare the potential for pathogenic aDNA retrieval from teeth and petrous bones, we sampled these elements from five ancient skeletons, previously shown to be carrying Yersinia pestis ...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29595343/on-the-persistence-and-detectability-of-ancient-beothuk-mitochondrial-dna-genomes-in-living-first-nations-peoples
#6
Ashley Collier, Steven M Carr
Claims have long been made as to the survival to the present day of descendants of the Newfoundland Beothuk, a group generally accepted to have become extinct with the death of the last known member, Shanawdithit, in 1829. Interest has recently been revived by the availability of commercial genetic testing, which some claim can assign living individuals to specific Native American groups. We compare complete mitogenome sequences (16569 bp) from aDNA of eight distinct Beothuk lineages, including Shanawdithit's uncle Nonosabasut and his wife Demasduit, with three Newfoundland Mi'kmaq lineages and 21 other living Native Americans drawn from GenBank...
March 29, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29444125/exploration-of-avocado-by-products-as-natural-sources-of-bioactive-compounds
#7
Maria Augusta Tremocoldi, Pedro Luiz Rosalen, Marcelo Franchin, Adna Prado Massarioli, Carina Denny, Érica Regina Daiuto, Jonas Augusto Rizzato Paschoal, Priscilla Siqueira Melo, Severino Matias de Alencar
This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic properties and phenolic composition of peel and seed of avocado varieties Hass and Fuerte using green solvents. Ethanol soluble compounds were identified in peel and seed of both varieties using HPLC-MS/MS and quantified using HPLC-DAD. Agro-industrial by-products of both varieties exhibited high radical scavenging activity against synthetic free radicals (DPPH and ABTS) and reactive oxygen species (peroxyl, superoxide, and hypochlorous acid) and high ability to reduce Fe3+ to Fe2+...
2018: PloS One
https://www.readbyqxmd.com/read/29440435/unique-parasite-adna-in-moa-coprolites-from-new-zealand-suggests-mass-parasite-extinctions-followed-human-induced-megafauna-extinctions
#8
Kevin D Lafferty, Skylar R Hopkins
No abstract text is available yet for this article.
February 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29426903/identifying-source-populations-for-the-reintroduction-of-the-eurasian-beaver-castor-fiber-l-1758-into-britain-evidence-from-ancient-dna
#9
Melissa M Marr, Selina Brace, Danielle C Schreve, Ian Barnes
Establishing true phylogenetic relationships between populations is a critical consideration when sourcing individuals for translocation. This presents huge difficulties with threatened and endangered species that have become extirpated from large areas of their former range. We utilise ancient DNA (aDNA) to reconstruct the phylogenetic relationships of a keystone species which has become extinct in Britain, the Eurasian beaver Castor fiber. We sequenced seventeen 492 bp partial tRNAPro and control region sequences from Late Pleistocene and Holocene age beavers and included these in network, demographic and genealogy analyses...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29399824/atlantic-mammal-traits-a-data-set-of-morphological-traits-of-mammals-in-the-atlantic-forest-of-south-america
#10
Fernando Gonçalves, Ricardo S Bovendorp, Gabrielle Beca, Carolina Bello, Raul Costa-Pereira, Renata L Muylaert, Raisa R Rodarte, Nacho Villar, Rafael Souza, Maurício E Graipel, Jorge J Cherem, Deborah Faria, Julio Baumgarten, Martín R Alvarez, Emerson M Vieira, Nilton Cáceres, Renata Pardini, Yuri L R Leite, Leonora P Costa, Marco A R Mello, Erich Fischer, Fernando C Passos, Luiz H Varzinczak, Jayme A Prevedello, Ariovaldo P Cruz-Neto, Fernando Carvalho, Alexandre R Percequillo, Agustin Paviolo, Alessandra Nava, José M B Duarte, Noé U de la Sancha, Enrico Bernard, Ronaldo G Morato, Juliana F Ribeiro, Rafael G Becker, Gabriela Paise, Paulo S Tomasi, Felipe Vélez-Garcia, Geruza L Melo, Jonas Sponchiado, Felipe Cerezer, Marília A S Barros, Albérico Q S de Souza, Cinthya C Dos Santos, Gastón A F Giné, Patricia Kerches-Rogeri, Marcelo M Weber, Guilherme Ambar, Lucía V Cabrera-Martinez, Alan Eriksson, Maurício Silveira, Carolina F Santos, Lucas Alves, Eder Barbier, Gabriela C Rezende, Guilherme S T Garbino, Élson O Rios, Adna Silva, Alexandre Túlio A Nascimento, Rodrigo S de Carvalho, Anderson Feijó, Juan Arrabal, Ilaria Agostini, Daniela Lamattina, Sebastian Costa, Ezequiel Vanderhoeven, Fabiano R de Melo, Plautino de Oliveira Laroque, Leandro Jerusalinsky, Mônica M Valença-Montenegro, Amely B Martins, Gabriela Ludwig, Renata B de Azevedo, Agustin Anzóategui, Marina X da Silva, Marcela Figuerêdo Duarte Moraes, Alexandre Vogliotti, Andressa Gatti, Thomas Püttker, Camila S Barros, Thais K Martins, Alexine Keuroghlian, Donald P Eaton, Carolina L Neves, Marcelo S Nardi, Caryne Braga, Pablo R Gonçalves, Ana Carolina Srbek-Araujo, Poliana Mendes, João A de Oliveira, Fábio A M Soares, Patrício A Rocha, Peter Crawshaw, Milton C Ribeiro, Mauro Galetti
Measures of traits are the basis of functional biological diversity. Numerous works consider mean species-level measures of traits while ignoring individual variance within species. However, there is a large amount of variation within species and it is increasingly apparent that it is important to consider trait variation not only between species, but also within species. Mammals are an interesting group for investigating trait-based approaches because they play diverse and important ecological functions (e...
February 2018: Ecology
https://www.readbyqxmd.com/read/29391530/inferring-genetic-origins-and-phenotypic-traits-of-george-b%C3%A3-hr-the-architect-of-the-dresden-frauenkirche
#11
Alexander Peltzer, Alissa Mittnik, Chuan-Chao Wang, Tristan Begg, Cosimo Posth, Kay Nieselt, Johannes Krause
For historic individuals, the outward appearance and other phenotypic characteristics remain often non-resolved. Unfortunately, images or detailed written sources are only scarcely available in many cases. Attempts to study historic individuals with genetic data so far focused on hypervariable regions of mitochondrial DNA and to some extent on complete mitochondrial genomes. To elucidate the potential of in-solution based genome-wide SNP capture methods - as now widely applied in population genetics - we extracted DNA from the 17th century remains of George Bähr, the architect of the Dresdner Frauenkirche...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328350/-helicobacter-pylori-dna-obtained-from-the-stomach-specimens-of-two-17-th-century-korean-mummies
#12
Dong Hoon Shin, Chang Seok Oh, Jong Ha Hong, Hyejin Lee, Soong Deok Lee, Eunju Lee
Helicobacter pylori is a bacterium that grows in the stomach mucosal epithelium, and can induce gastric diseases. Although many studies on modern H. pylori genomes have been reported from all over the world, a comprehensive picture of H. pylori is still lacking. Therefore, there is a pressing need to obtain archaeological specimens and to subject the ancient DNA (aDNA) extracted therefrom to analysis. Considering the typically excellent state of preservation of Joseon mummies discovered in Korea, we thus tried to isolate ancient H...
February 1, 2018: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/29304796/referral-gynecological-ambulatory-clinic-principal-diagnosis-and-distribution-in-health-services
#13
Adna Thaysa Marcial da Silva, Camila Lohmann Menezes, Edige Felipe de Sousa Santos, Paulo Francisco Ramos Margarido, José Maria Soares, Edmund Chada Baracat, Luiz Carlos de Abreu, Isabel Cristina Esposito Sorpreso
BACKGROUND: The association between gynecological diagnoses and their distribution in the health sectors provides benefits in the field of women's health promotion and in medical and interdisciplinary education, along with rationalization according to level of care complexity. Thus, the objective is analyze the clinical-demographic characteristics, main diagnoses in gynecological ambulatory care, and their distribution in health services. METHOD: This is a research project of retrospective audit study design with a chart review of data from 428 women treated at University Ambulatory Clinic of Women's Health, the facility in gynecology and training for Family and Community Medical Residents, São Paulo, Brazil, from 2012 to 2014...
January 5, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29246100/investigating-population-continuity-with-ancient-dna-under-a-spatially-explicit-simulation-framework
#14
Nuno Miguel Silva, Jeremy Rio, Mathias Currat
BACKGROUND: Recent advances in sequencing technologies have allowed for the retrieval of ancient DNA data (aDNA) from skeletal remains, providing direct genetic snapshots from diverse periods of human prehistory. Comparing samples taken in the same region but at different times, hereafter called "serial samples", may indicate whether there is continuity in the peopling history of that area or whether an immigration of a genetically different population has occurred between the two sampling times...
December 15, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29209321/consumption-of-diet-containing-free-amino-acids-exacerbates-colitis-in-mice
#15
Adna Luciana Souza, Sarah Leão Fiorini Aguiar, Mariana Camila Gonçalves Miranda, Luisa Lemos, Mauro Andrade Freitas Guimaraes, Daniela Silva Reis, Patrícia Aparecida Vieira Barros, Emerson Soares Veloso, Toniana Gonçalves Carvalho, Fabiola Mara Ribeiro, Enio Ferreira, Denise Carmona Cara, Ana Cristina Gomes-Santos, Ana Maria Caetano Faria
Dietary proteins can influence the maturation of the immune system, particularly the gut-associated lymphoid tissue, when consumed from weaning to adulthood. Moreover, replacement of dietary proteins by amino acids at weaning has been shown to impair the generation of regulatory T cells in the gut as well as immune activities such as protective response to infection, induction of oral and nasal tolerance as well as allergic responses. Polymeric and elemental diets are used in the clinical practice, but the specific role of intact proteins and free amino acids during the intestinal inflammation are not known...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29205120/synthesis-and-in-vitro-antioxidant-activity-study-of-some-novel-substituted-piperazinyl-flavone-compounds
#16
Elmas Sari, Paweł Berczynski, Aleksandra Kładna, Irena Kruk, Oya B Dundar, Monika Szymanska, Hassan Y Aboul-Enein
BACKGROUND: A new series of 13 piperazinyl flavone derivatives has been synthesized and examined for their in vitro antiradical and antioxidant activities as response to the pharmacy industry's increasing demand for new non-toxic anti-inflammatory and anticancer drugs. METHODS: Their antioxidant activity was evaluated by the reactive oxygen species (ROS) scavenging assays, 2,2-diphenyl-1-picrylhydrazyl free radical (DPPH ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical cation (ABTS+ ) scavenging assays, and the ferric reducing antioxidant potency (TAC) method, and compared to known positive controls, herbal infusions, and penicillins...
December 3, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29162098/malaria-early-warning-tool-linking-inter-annual-climate-and-malaria-variability-in-northern-guadalcanal-solomon-islands
#17
Jason Smith, Lloyd Tahani, Albino Bobogare, Hugo Bugoro, Francis Otto, George Fafale, David Hiriasa, Adna Kazazic, Grant Beard, Amanda Amjadali, Isabelle Jeanne
BACKGROUND: Malaria control remains a significant challenge in the Solomon Islands. Despite progress made by local malaria control agencies over the past decade, case rates remain high in some areas of the country. Studies from around the world have confirmed important links between climate and malaria transmission. This study focuses on understanding the links between malaria and climate in Guadalcanal, Solomon Islands, with a view towards developing a climate-based monitoring and early warning for periods of enhanced malaria transmission...
November 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29117125/the-small-and-the-dead-a-review-of-ancient-dna-studies-analysing-micromammal-species
#18
REVIEW
Roseina Woods, Melissa M Marr, Selina Brace, Ian Barnes
The field of ancient DNA (aDNA) has recently been in a state of exponential growth, largely driven by the uptake of Next Generation Sequencing (NGS) techniques. Much of this work has focused on the mammalian megafauna and ancient humans, with comparatively less studies looking at micromammal fauna, despite the potential of these species in testing evolutionary, environmental and taxonomic theories. Several factors make micromammal fauna ideally suited for aDNA extraction and sequencing. Micromammal subfossil assemblages often include the large number of individuals appropriate for population level analyses, and, furthermore, the assemblages are frequently found in cave sites where the constant temperature and sheltered environment provide favourable conditions for DNA preservation...
November 8, 2017: Genes
https://www.readbyqxmd.com/read/29114402/comparative-scaffolding-and-gap-filling-of-ancient-bacterial-genomes-applied-to-two-ancient-yersinia-pestis-genomes
#19
Nina Luhmann, Daniel Doerr, Cedric Chauve
Yersinia pestis is the causative agent of the bubonic plague, a disease responsible for several dramatic historical pandemics. Progress in ancient DNA (aDNA) sequencing rendered possible the sequencing of whole genomes of important human pathogens, including the ancient Y. pestis strains responsible for outbreaks of the bubonic plague in London in the 14th century and in Marseille in the 18th century, among others. However, aDNA sequencing data are still characterized by short reads and non-uniform coverage, so assembling ancient pathogen genomes remains challenging and often prevents a detailed study of genome rearrangements...
September 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29065339/reduced-graphene-oxide-bifeo3-nanohybrids-based-signal-on-photoelectrochemical-sensing-system-for-prostate-specific-antigen-detection-coupling-with-magnetic-microfluidic-device
#20
Qian Zhou, Youxiu Lin, Kangyao Zhang, Meijin Li, Dianping Tang
A novel magnetic controlled photoelectrochemical (PEC) sensing system was designed for sensitive detection of prostate-specific antigen (PSA) using reduced graphene oxide-functionalized BiFeO3 (rGO-BiFeO3) as the photoactive material and target-triggered hybridization chain reaction (HCR) for signal amplification. Remarkably enhanced PEC performance could be obtained by using rGO-BiFeO3 as the photoelectrode material due to its accelerated charge transfer and improved the visible light absorption. Additionally, efficient and simple operation could be achieved by introducing magnetic controlled flow-through device...
October 16, 2017: Biosensors & Bioelectronics
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