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Safety culture

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https://www.readbyqxmd.com/read/29777389/iron-based-metal-organic-frameworks-as-a-theranostic-carrier-for-local-tuberculosis-therapy
#1
Gabriela Wyszogrodzka, Przemysław Dorożyński, Barbara Gil, Wieslaw J Roth, Maciej Strzempek, Bartosz Marszałek, Władysław P Węglarz, Elżbieta Menaszek, Weronika Strzempek, Piotr Kulinowski
PURPOSE: The purpose of the study was initial evaluation of applicability of metal organic framework (MOF) Fe-MIL-101-NH2 as a theranostic carrier of antituberculous drug in terms of its functionality, i.e. drug loading, drug dissolution, magnetic resonance imaging (MRI) contrast and cytotoxic safety. METHODS: Fe-MIL-101-NH2 was characterized using X-ray powder diffraction, FTIR spectrometry and scanning electron microscopy. The particle size analysis was determined using laser diffraction...
May 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29776002/the-chaos-of-hospitalisation-for-patients-with-critical-limb-ischaemia-approaching-major-amputation
#2
Susan Monaro, Sandra West, Jana Pinkova, Janice Gullick
AIMS AND OBJECTIVES: To illuminate the hospital experience for patients and families when major amputation has been advised for critical limb ischaemia (CLI). BACKGROUND: CLI creates significant burden to the health system and the family, particularly as the person with CLI approaches amputation. Major amputation is often offered as a late intervention for CLI in response to the marked deterioration of an ischaemic limb, and functional decline from reduced mobility, intractable pain, infection and/or toxaemia...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29774970/priming-patient-safety-a-middle-range-theory-of-safety-goal-priming-via-safety-culture-communication
#3
Patricia S Groves, Jacinda L Bunch
The aim of this paper is discussion of a new middle-range theory of patient safety goal priming via safety culture communication. Bedside nurses are key to safe care, but there is little theory about how organizations can influence nursing behavior through safety culture to improve patient safety outcomes. We theorize patient safety goal priming via safety culture communication may support organizations in this endeavor. According to this theory, hospital safety culture communication activates a previously held patient safety goal and increases the perceived value of actions nurses can take to achieve that goal...
May 18, 2018: Nursing Inquiry
https://www.readbyqxmd.com/read/29774019/long-term-effects-of-residual-chlorine-on-pseudomonas-aeruginosa-in-simulated-drinking-water-fed-with-low-aoc-medium
#4
Guannan Mao, Yuhao Song, Mark Bartlam, Yingying Wang
Residual chlorine is often required to remain present in public drinking water supplies during distribution to ensure water quality. It is essential to understand how bacteria respond to long-term chlorine exposure, especially with the presence of assimilable organic carbon (AOC). This study aimed to investigate the effects of chlorination on Pseudomonas aeruginosa in low AOC medium by both conventional plating and culture-independent methods including flow cytometry (FCM) and quantitative PCR (qPCR). In a simulated chlorinated system using a bioreactor, membrane damage and DNA damage were measured by FCM fluorescence fingerprint...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29772687/metformin-induces-apoptosis-and-alters-cellular-responses-to-oxidative-stress-in-ht29-colon-cancer-cells-preliminary-findings
#5
Paola Sena, Stefano Mancini, Marta Benincasa, Francesco Mariani, Carla Palumbo, Luca Roncucci
Accumulating evidence suggests that metformin, used as an antidiabetic drug, possesses anti-cancer properties. Metformin reduced the incidence and growth of experimental tumors in vivo. In a randomized clinical trial among nondiabetic patients, metformin treatment significantly decreased the number of aberrant crypt foci compared to the untreated group with a follow-up of 1 month. In our study, HT29 cells were treated with graded concentrations of metformin, 10 mM/25 mM/50 mM for 24/48 h. We performed immunofluorescence experiments by means of confocal microscopy and western blot analysis to evaluate a panel of factors involved in apoptotic/autophagic processes and oxidative stress response...
May 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29767578/-death-is-difficult-in-any-language-a-qualitative-study-of-palliative-care-professionals-experiences-when-providing-end-of-life-care-to-patients-from-culturally-and-linguistically-diverse-backgrounds
#6
Anna Green, Natalia Jerzmanowska, Marguerite Green, Elizabeth A Lobb
BACKGROUND: Ethnic minority patients have unique challenges in accessing health services. These include language difficulties, unfamiliarity with the health system, lower rates of cancer screening and survival, higher rates of reported side effects from cancer treatment and poorer quality of life. Little is known about this patient group when transitioning to palliative care. AIM: To elicit the experiences of palliative care health professionals when providing care for patients from culturally and linguistically diverse backgrounds which differ from mainstream Australian language and culture...
May 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29766570/melatonin-improves-endothelial-function-in-vitro-and-prolongs-pregnancy-in-women-with-early-onset-preeclampsia
#7
Sebastian R Hobson, Seshi Gurusinghe, Rebecca Lim, Nicole O Alers, Suzanne L Miller, John C Kingdom, Euan M Wallace
Preeclampsia remains a leading cause of maternal and perinatal morbidity and mortality. There have been no material advances in the treatment of preeclampsia for nearly 50 years. Combining in vitro studies and a clinical trial, we aimed to determine if melatonin could be a useful adjuvant therapy. In a xanthine/xanthine oxidase (X/XO) placental explant model, melatonin reduced oxidative stress (8-isoprostane) and enhanced antioxidant markers (Nrf2 translocation, HO-1), but did not affect explant production of anti-angiogenic factors (sFlt, sEng, activin A)...
May 16, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29766338/an-unusual-surgical-indication-for-cerebral-tuberculosis-status-dystonicus-case-report
#8
Andrea Franzini, Angelo Franzini, Vincenzo Levi, Roberto Cordella, Giuseppe Messina
Actual indications for surgery in tuberculosis are limited to obtaining a diagnosis, acquiring tissue for culture studies, treating hydrocephalus, aspiring a brain abscess, and reducing intracranial pressure in patients with multiple tuberculomas. Tuberculosis-related movement disorders are usually treated pharmacologically. We report on a child affected by post-tubercular generalized dystonia, who progressed to status dystonicus (SD) and underwent stereotactic bilateral pallidotomy. After surgery, SD resolved, and drugs were rapidly tapered...
May 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29765596/an-evolutionary-perspective-on-night-terrors
#9
Sean D Boyden, Martha Pott, Philip T Starks
Night terrors, also known as sleep terrors, are an early childhood parasomnia characterized by screams or cries, behavioral manifestations of extreme fear, difficulty waking and inconsolability upon awakening. The mechanism causing night terrors is unknown, and a consistently successful treatment has yet to be documented. Here, we argue that cultural practices have moved us away from an ultimate solution: cosleeping. Cosleeping is the norm for closely related primates and for humans in non-Western cultures...
2018: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/29765415/human-recombinant-peptide-sponge-enables-novel-less-invasive-cell-therapy-for-ischemic-stroke
#10
Michiyuki Miyamoto, Kentaro Nakamura, Hideo Shichinohe, Tomohiro Yamauchi, Masaki Ito, Hisayasu Saito, Masahito Kawabori, Toshiya Osanai, Tasuku Sasaki, Kiyohiro Houkin, Satoshi Kuroda
Bone marrow stromal cell (BMSC) transplantation has the therapeutic potential for ischemic stroke. However, it is unclear which delivery routes would yield both safety and maximal therapeutic benefits. We assessed whether a novel recombinant peptide (RCP) sponge, that resembles human collagen, could act as a less invasive and beneficial scaffold in cell therapy for ischemic stroke. BMSCs from green fluorescent protein-transgenic rats were cultured and Sprague-Dawley rats were subjected to permanent middle cerebral artery occlusion (MCAo)...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29764889/autologous-stem-cells-in-achilles-tendinopathy-ascat-protocol-for-a-phase-iia-single-centre-proof-of-concept-study
#11
Andrew J Goldberg, Razi Zaidi, Deirdre Brooking, Louise Kim, Michelle Korda, Lorenzo Masci, Ruth Green, Paul O'Donnell, Roger Smith
INTRODUCTION: Achilles tendinopathy (AT) is a cause of pain and disability affecting both athletes and sedentary individuals. More than 150 000 people in the UK every year suffer from AT.While there is much preclinical work on the use of stem cells in tendon pathology, there is a scarcity of clinical data looking at the use of mesenchymal stem cells to treat tendon disease and there does not appear to be any studies of the use of autologous cultured mesenchymal stem cells (MSCs) for AT...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29762887/the-underreporting-of-medication-errors-a-retrospective-and-comparative-root-cause-analysis-in-an-acute-mental-health-unit-over-a-3-year-period
#12
Maeve Morrison, Vicki Cope, Melanie Murray
Medication errors remain a commonly reported clinical incident in health care as highlighted by the World Health Organization's focus to reduce medication-related harm. This retrospective quantitative analysis examined medication errors reported by staff using an electronic Clinical Incident Management System (CIMS) during a 3-year period from April 2014 to April 2017 at a metropolitan mental health ward in Western Australia. The aim of the project was to identify types of medication errors and the context in which they occur and to consider recourse so that medication errors can be reduced...
May 15, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29762797/contrasting-incoming-medical-students-attitudes-dual-degree-vs-traditional-tracks
#13
Kristina A Monteiro, Karl Dietrich, Jeffrey Borkan, Luba Dumenco, Allan R Tunkel, Richard Dollase, Paul George
BACKGROUND AND OBJECTIVES: The Warren Alpert Medical School of Brown University (AMS) recently implemented a novel dual degree MD-ScM program in primary care and population medicine (PC-PM) that enrolls up to 24 of its nearly 144 yearly matriculants. The overarching goal of this track is to train medical students to become physician leaders who focus on issues in population medicine within primary care. METHODS: We conducted a baseline assessment of the students enrolled in this parallel track in comparison to our traditional students to identify characteristics of and group differences between students in the PC-PM program and traditional students...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29760597/application-of-an-incident-taxonomy-for-radiation-therapy-analysis-of-five-years-of-data-from-three-integrated-cancer-centres
#14
Stuart Greenham, Stephen Manley, Kirsty Turnbull, Matthew Hoffmann, Amara Fonseca, Justin Westhuyzen, Andrew Last, Noel J Aherne, Thomas P Shakespeare
Aim: To develop and apply a clinical incident taxonomy for radiation therapy. Background: Capturing clinical incident information that focuses on near-miss events is critical for achieving higher levels of safety and reliability. Methods and materials: A clinical incident taxonomy for radiation therapy was established; coding categories were prescription, consent, simulation, voluming, dosimetry, treatment, bolus, shielding, imaging, quality assurance and coordination of care...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29760364/-pharmacology-education-in-nursing-based-on-the-patient-oriented-pharmacology-personal-drug-p-drug-and-integrated-drug-idrug
#15
Toshihiko Yanagita
The installation of nursing colleges/universities has rapidly increased from the late 1990s, there are 255 institutions in Japan as of 2017. Pharmacology and clinical pharmacology education in undergraduate and postgraduate nursing colleges/universities is highly important, however, the lack of human resources involved in pharmacology education due to the rapid increase of nursing colleges/universities cannot be denied. The Ministry of Education, Culture, Sports, Science and Technology of Japan established a 〝nursing education model core curriculum〟 for quality assurance of education at nursing colleges/universities...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29759284/quality-and-the-health-system-becoming-a-high-reliability-organization
#16
REVIEW
Monaliza Gaw, Frank Rosinia, Thomas Diller
Since the publication of "To Err is Human" in 1999, substantial efforts have been made within the health care industry to improve quality and patient safety. Although improvements have been made, recent estimates continue to indicate the need for a marked change in approach. In this article, the authors discuss the concepts and characteristics of high reliability organizations, safety culture, and clinical microsystems. The health care delivery system must move beyond current quality and patient safety approaches and fully engage in these new concepts to transform health care system performance...
June 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29759281/measuring-quality-for-individual-anesthesia-clinicians
#17
REVIEW
John Allyn, Craig Curry
A robust quality management system (QMS) will provide value to patients, providers, and hospitals or systems by focusing on system performance. The QMS must remain independent of provider-specific measures used for privileging. Some outcome measures may be used to assess system performance; they must not be used to assess individual provider performance. All anesthesia providers, especially leaders, must be guardians of an organization's safety culture.
June 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29758485/isolation-characterization-and-strain-selection-of-a-paenibacillus-species-for-use-as-a-probiotic-to-aid-in-ruminal-methane-mitigation-nitrate-nitrite-detoxification-and-food-safety
#18
Elizabeth A Latham, William E Pinchak, Julian Trachsel, Heather K Allen, Todd R Callaway, David J Nisbet, Robin C Anderson
The effects of dietary nitrate and Paenibacillus 79R4 (79R4), a denitrifying bacterium, when co-administered as a probiotic, on methane emissions, nitrate and nitrite-metabolizing capacity and fermentation characteristics were studied in vitro. Mixed populations of rumen microbes inoculated with 79R4 metabolized all levels of nitrite studied after 24 h in vitro incubation. Results from in vitro simulations resulted in up to 2 log10 colony forming unit reductions in E. coli O157:H7 and Campylobacter jejuni when these were co-cultured with 79R4...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29758128/nurses-perceptions-of-patient-safety-culture-in-three-hospitals-in-saudi-arabia
#19
Nahed Alquwez, Jonas Preposi Cruz, Ahmed Mohammed Almoghairi, Raid Salman Al-Otaibi, Khalid Obaid Almutairi, Jerico G Alicante, Paolo C Colet
PURPOSE: To assess the present patient safety culture of three general hospitals in Saudi Arabia, as perceived by nurses. DESIGN: This study utilized a descriptive, cross-sectional design. METHODS: A convenience sample of 351 nurses working in three general hospitals in the central region of Saudi Arabia was surveyed in this study using the Hospital Survey of Patients' Safety Culture (HSOPSC) from October 2016 to April 2017. RESULTS: From the 12 composites of the HSOPSC, the nurses perceived only the following two patient safety areas as strengths: teamwork within units and organizational learning-continuous improvement...
May 14, 2018: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29757934/comparison-of-synthetic-media-designed-for-expansion-of-adipose-derived-mesenchymal-stromal-cells
#20
Michelle Lensch, Angela Muise, Lisa White, Michael Badowski, David Harris
Mesenchymal stromal cells (MSCs) are multipotent cells that can differentiate into various cell types, such as osteoblasts, myocytes, and adipocytes. This characteristic makes the cells a useful tool in developing new therapies for a number of common maladies and diseases. The utilization of animal-derived growth serum, such as fetal bovine serum (FBS), for the expansion of MSCs has traditionally been used for cell culture. However, in clinical applications, animal-derived products present limitations and safety concerns for the recipient, as exposure to animal (xeno-) antigens and infectious agents is possible...
May 14, 2018: Biomedicines
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