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https://www.readbyqxmd.com/read/29232764/brain-biopsy-performed-with-the-ronna-g3-system-a-case-study-on-using-a-novel-robotic-navigation-device-for-stereotactic-neurosurgery
#1
Domagoj Dlaka, Marko Švaco, Darko Chudy, Bojan Jerbić, Bojan Šekoranja, Filip Šuligoj, Josip Vidaković, Fadi Almahariq, Dominik Romić
BACKGROUND: Robotic neuronavigation is becoming an important tool for neurosurgeons. We present a case study of a frameless stereotactic biopsy guided by the RONNA G3 robotic neuronavigation system. METHODS: A 45 year-old patient with a history of vertigo, nausea and vomiting was diagnosed with multiple periventricular lesions. Neurological status was unremarkable. A frameless robotic biopsy of a brain lesion was performed. RESULTS: Three tissue samples were obtained...
December 12, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29232545/influence-of-the-social-determinants-of-health-on-access-to-healthcare-services-among-refugees-in-australia
#2
Jessica Taylor, Greer Lamaro Haintz
Refugees in Australia are not fully utilising the healthcare system for several reasons and this may be affecting their overall health outcomes. This qualitative systematic review examined the influence of the social determinants of health on refugees' access to healthcare services in Australia. Electronic databases were searched using terms relating to refugees, social determinants, healthcare services, barriers, enablers and Australia. Only peer-reviewed studies published in English since 2006, which focused on refugees and specifically discussed social determinants influencing refugees' access to healthcare services in Australia, were included...
December 13, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29232373/disentangling-metabolic-functions-of-bacteria-in-the-honey-bee-gut
#3
Lucie Kešnerová, Ruben A T Mars, Kirsten M Ellegaard, Michaël Troilo, Uwe Sauer, Philipp Engel
It is presently unclear how much individual community members contribute to the overall metabolic output of a gut microbiota. To address this question, we used the honey bee, which harbors a relatively simple and remarkably conserved gut microbiota with striking parallels to the mammalian system and importance for bee health. Using untargeted metabolomics, we profiled metabolic changes in gnotobiotic bees that were colonized with the complete microbiota reconstituted from cultured strains. We then determined the contribution of individual community members in mono-colonized bees and recapitulated our findings using in vitro cultures...
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29232345/factors-associated-with-lack-of-vision-improvement-in-children-with-cortical-visual-impairment
#4
Swati Handa, Seyed E Saffari, Mark Borchert
BACKGROUND: Improvement in vision has been noted in children with cortical visual impairment (CVI), resulting from disparate types of brain injury. The purpose of our study was to determine the risk factors associated with poor recovery of vision in this group of patients. METHODS: Case records of children who were born before 2010 with at least 4 follow-up visits for CVI were reviewed for underlying etiologies of CVI, visual acuity (VA), and associated neurological and ophthalmological disorders...
December 8, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29232342/intraoperative-near-infrared-fluorescence-imaging-of-multiple-pancreatic-neuroendocrine-tumors-a-case-report
#5
Henricus J M Handgraaf, Leonora S F Boogerd, Shirin Shahbazi Feshtali, Arantza Fariña Sarasqueta, Marieke Snel, Rutger-Jan Swijnenburg, Alexander L Vahrmeijer, Bert A Bonsing, J Sven D Mieog
Multiple endocrine neoplasia type 1 syndrome can feature pancreatic neuroendocrine lesions that have the potential to degenerate into malignancies (pancreatic neuroendocrine tumors [PNETs]). Resection is required in selected cases and aims to cure patients and to prevent metastasis. Preoperative imaging is important to assess the number, size, and location of PNETs. However, sensitivity of preoperative imaging modalities to detect small lesions can be rather disappointing. This makes intraoperative reassessment of the pancreas crucial...
January 2018: Pancreas
https://www.readbyqxmd.com/read/29232277/scaling-up-hiv-self-testing-in-sub-saharan-africa-a-review-of-technology-policy-and-evidence
#6
Pitchaya P Indravudh, Augustine T Choko, Elizabeth L Corbett
PURPOSE OF REVIEW: HIV self-testing (HIVST) can provide complementary coverage to existing HIV testing services and improve knowledge of status among HIV-infected individuals. This review summarizes the current technology, policy and evidence landscape in sub-Saharan Africa and priorities within a rapidly evolving field. RECENT FINDINGS: HIVST is moving towards scaled implementation, with the release of WHO guidelines, WHO prequalification of the first HIVST product, price reductions of HIVST products and a growing product pipeline...
December 9, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29232130/atom-transfer-radical-polymerization-of-multi-shelled-cationic-corona-for-the-systemic-delivery-of-sirna
#7
Hyesung Kim, Young Ju Son, Wei Mao, Kam W Leong, Hyuk Sang Yoo
We propose an effective siRNA delivery system by preparing poly(DAMA-HEMA)-multilayered gold nanoparticles using multiple surface-initiated atom transfer radical polymerization (SI-ATRP) processes. The polymeric multilayer structure is characterized by transmission electron microscopy (TEM), matrix-associated laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and ζ-potential. The amount of siRNA electrostatically incorporated into the nanoparticle can be tuned by the number of polymeric shells, which in turn influences the cellular uptake and gene silencing effect...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29232113/hyperbranched-polyglycerol-loaded-with-zinc-porphyrins-photosensitizer-release-under-reductive-and-acidic-conditions-for-improved-photodynamic-therapy
#8
Michael H Staegemann, Susanna Gräfe, Burkhard Gitter, Katharina Achazi, Elisa Quaas, Rainer Haag, Arno Wiehe
An adaptable approach toward cleavable nanoparticle carrier systems for photodynamic therapy (PDT) is presented, comprising a biocompatible carrier loaded with multiple photosensitizer (PS) molecules related to the clinically employed PS Temoporfin, two linkers cleavable under different triggers and glyco-targeting with mannose. A synthetic pathway to stimuli responsive hyperbranched polyglycerol (hPG) porphyrin conjugates via the copper(I)-catalyzed 1,3-dipolar cycloaddition (CuAAC) or the strain-promoted alkyne-azide cycloaddition (SPAAC) has been developed...
December 12, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29232054/high-speed-microscopy-for-in-vivo-monitoring-of-lymph-dynamics
#9
Mustafa Sarimollaoglu, Amanda J Stolarz, Dmitry A Nedosekin, Brittney R Garner, Terry W Fletcher, Ekaterina I Galanzha, Nancy J Rusch, Vladimir P Zharov
The lymphatic system contributes to body homeostasis by clearing fluid, lipids, plasma proteins, and immune cells from the interstitial space. Many studies have been performed to understand lymphatic function under normal conditions and during disease. Nevertheless, a further improvement in quantification of lymphatic behavior is needed. Here, we present advanced bright-field microscopy for in vivo imaging of lymph vessels and automated quantification of lymphatic function at temporal resolution of 2 ms. Full frame videos were compressed and recorded continuously at up to 540 frames per second...
December 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29231920/two-colour-serial-femtosecond-crystallography-dataset-from-gadoteridol-derivatized-lysozyme-for-mad-phasing
#10
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R Bruce Doak, Marie Luise Grünbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Nass Kovács, Eriko Nango, Karol Nass, Christopher M Roome, Robert L Shoeman, Rie Tanaka, Kensuke Tono, Lutz Foucar, Yasumasa Joti, Makina Yabashi, So Iwata, Kiyoshi Ueda, Thomas R M Barends, Ilme Schlichting
We provide a detailed description of a gadoteridol-derivatized lysozyme (gadolinium lysozyme) two-colour serial femtosecond crystallography (SFX) dataset for multiple wavelength anomalous dispersion (MAD) structure determination. The data was collected at the Spring-8 Angstrom Compact free-electron LAser (SACLA) facility using a two-colour double-pulse beam to record two diffraction patterns simultaneously in one diffraction image. Gadolinium lysozyme was chosen as a well-established model system that has a very strong anomalous signal...
December 12, 2017: Scientific Data
https://www.readbyqxmd.com/read/29231813/evolutionary-transitions-between-beneficial-and-phytopathogenic-rhodococcus-challenge-disease-management
#11
Elizabeth A Savory, Skylar L Fuller, Alexandra J Weisberg, William J Thomas, Michael I Gordon, Danielle M Stevens, Allison L Creason, Michael S Belcher, Maryna Serdani, Michele S Wiseman, Niklaus J Grünwald, Melodie L Putnam, Jeff H Chang
Understanding how bacteria affect plant health is crucial for developing sustainable crop production systems. We coupled ecological sampling and genome sequencing to characterize the population genetic history of Rhodococcus and the distribution patterns of virulence plasmids in isolates from nurseries. Analysis of chromosome sequences shows that plants host multiple lineages of Rhodococcus, and suggested that these bacteria are transmitted due to independent introductions, reservoir populations, and point source outbreaks...
December 12, 2017: ELife
https://www.readbyqxmd.com/read/29231509/-summary-of-professor-yang-jun-s-experience-for-intractable-facial-paralysis
#12
Tao Wang, Zaiyuan Li, Tingqiu Ge, Man Zhang, Aihong Yuan, Jun Yang
Professor YANG Jun's experience of diagnosis and treatment for intractable facial paralysis is introduced. Professor YANG focuses on the thinking model that combines TCM, western medicine and acupuncture, and adopts the differentiation system that combines disease differentiation, syndrome differentiation and meridian differentiation; he adopts the treatment integrates etiological treatment, overall regulation, symptomatic treatment as well as acupuncture, moxibustion, medication and flash cupping. The acupoints of yangming meridians are mostly selected, and acupoints of governor vessel such as Dazhui (GV 14) and Jinsuo (GV 8) are highly valued...
June 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29231243/neuromuscular-electrical-stimulation-nmes-for-patellofemoral-pain-syndrome
#13
REVIEW
Ana Luiza C Martimbianco, Maria Regina R Torloni, Brenda Ng Andriolo, Gustavo Jm Porfírio, Rachel Riera
BACKGROUND: Patellofemoral pain syndrome, now generally referred to as patellofemoral pain (PFP), is one of the most common orthopaedic disorders, characterised by pain in the anterior or retropatellar knee region. Neuromuscular electrical stimulation (NMES) has been proposed generally as a complementary treatment, associated with other interventions such as exercise, or as a single treatment to increase muscle force, reduce knee pain, and improve function. OBJECTIVES: To assess the effects (benefits and harms) of neuromuscular electrical stimulation for people with patellofemoral pain...
December 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29231145/learning-from-multiple-classifier-systems-perspectives-for-improving-decision-making-of-qsar-models-in-medicinal-chemistry
#14
Hai V Pham-The, Nguyen-Hai Nam, Doan-Viet Nga, Dang Thanh Hai, Karel Dieguez-Santana, Yovani Marrero-Poncee, Juan A Castillo-Garit, Gerardo M Casanola-Martin, Huong Le-Thi-Thu
Quantitative Structure - Activity Relationship (QSAR) modeling has been widely used in medicinal chemistry and computational toxicology for many years. Today, as the amount of data on chemicals is increasing dramatically, QSAR methods have become pivotal for the purpose of handling the data, identifying a decision, and gathering useful information from data processing. The advances in this field have paved a way for numerous alternative approaches that require deep mathematics in order to enhance the learning capability of QSAR models...
December 11, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29231062/promising-immunotherapy-for-prostate-cancer
#15
John C Henegan, Guru Sonpavde
Sipuleucel-T is the only currently approved immunotherapy for the management of prostate cancer. However, other immunotherapy agents have recently shown activity in prostate cancer and are being developed alone or in combination with other agents. Areas covered: This article provides a review of positive or encouraging clinical trials of agents under development including vaccines, monoclonal antibodies, immune modulators, gene-mediated cytotoxic immunotherapy and chimeric antigen receptor-modified 'designer' T cells in patients with prostate cancer...
December 12, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29230966/transcriptome-analysis-and-anaerobic-c4-dicarboxylate-transport-in-actinobacillus-succinogenes
#16
Mi Na Rhie, Byeonghyeok Park, Hyeok-Jin Ko, In-Geol Choi, Ok Bin Kim
A global transcriptome analysis of the natural succinate producer Actinobacillus succinogenes revealed that 353 genes were differentially expressed when grown on various carbon and energy sources, which were categorized into six functional groups. We then analyzed the expression pattern of 37 potential C4 -dicarboxylate transporters in detail. A total of six transporters were considered potential fumarate transporters: three transporters, Asuc_1999 (Dcu), Asuc_0304 (DASS), and Asuc_0270-0273 (TRAP), were constitutively expressed, whereas three others, Asuc_1568 (DASS), Asuc_1482 (DASS), and Asuc_0142 (Dcu), were differentially expressed during growth on fumarate...
December 12, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29230939/normative-values-and-factors-affecting-water-perfused-esophageal-high-resolution-impedance-manometry-for-a-chinese-population
#17
P-H Tseng, R K M Wong, J-F Wu, C-C Chen, C-H Tu, Y-C Lee, H-C Lee, H-P Wang, M-S Wu
BACKGROUND: Combined esophageal high-resolution impedance manometry (HRIM) measures multiple pressures and bolus transit simultaneously, facilitating detailed assessment of esophageal motility. Currently, normative values for water-perfused HRIM systems for Chinese populations are lacking. METHODS: Healthy volunteers were enrolled for comprehensive anthropometric measures, blood biochemistry tests, and an HRIM study using 22 water-perfused pressure sensors and 12 impedance channels...
December 12, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29230877/neonatal-mouse-cortical-but-not-isogenic-human-astrocyte-feeder-layers-enhance-the-functional-maturation-of-induced-pluripotent-stem-cell-derived-neurons-in-culture
#18
Fritz W Lischka, Anastasia Efthymiou, Qiong Zhou, Michael D Nieves, Nikki M McCormack, Matthew D Wilkerson, Gauthaman Sukumar, Clifton L Dalgard, Martin L Doughty
Human induced pluripotent stem (iPS) cell-derived neurons and astrocytes are attractive cellular tools for nervous system disease modeling and drug screening. Optimal utilization of these tools requires differentiation protocols that efficiently generate functional cell phenotypes in vitro. As nervous system function is dependent on networked neuronal activity involving both neuronal and astrocytic synaptic functions, we examined astrocyte effects on the functional maturation of neurons from human iPS cell-derived neural stem cells (NSCs)...
December 12, 2017: Glia
https://www.readbyqxmd.com/read/29230860/cardiac-gating-using-scattering-of-an-8-channel-parallel-transmit-coil-at-7t
#19
Sven H F Jaeschke, Matthew D Robson, Aaron T Hess
PURPOSE: To establish a cardiac signal from scattering matrix or scattering coefficient measurements made on a 7T 8-channel parallel transmit (pTx) system, and to evaluate its use for cardiac gating. METHODS: Measurements of the scattering matrix and scattering coefficients were acquired using a monitoring pulse sequence and during a standard cine acquisition, respectively. Postprocessing used an independent component analysis and gating feature identification. The effect of the phase of the excitation radiofrequency (RF) field ( B1+ shim) on the cardiac signal was simulated for multiple B1+ shim configurations, and cine images were reconstructed from both the scattering coefficients and electrocardiogram (ECG)...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29230714/obesity-phenotypes-depot-differences-in-adipose-tissue-and-their-clinical-implications
#20
REVIEW
Valeria Guglielmi, Paolo Sbraccia
Obesity, defined as excess fat mass, increases risks for multiple chronic diseases, such as type 2 diabetes, cardiovascular disease, and several types of cancer. Beyond adiposity per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for obesity complications. Not only factors as genetics, environment, gender, and age account for the apparent compartmentalization of white adipose tissue (WAT) in the body...
December 11, 2017: Eating and Weight Disorders: EWD
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