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https://www.readbyqxmd.com/read/29471544/10-best-resources-on-power-in-health-policy-and-systems-in-low-and-middle-income-countries
#1
Veena Sriram, Stephanie M Topp, Marta Schaaf, Arima Mishra, Walter Flores, Subramania Raju Rajasulochana, Kerry Scott
Power is a critical concept to understand and transform health policy and systems. Power manifests implicitly or explicitly at multiple levels-local, national and global-and is present at each actor interface, therefore shaping all actions, processes and outcomes. Analysing and engaging with power has important potential for improving our understanding of the underlying causes of inequity, and our ability to promote transparency, accountability and fairness. However, the study and analysis of the role of power in health policy and systems, particularly in the context of low- and middle-income countries, has been lacking...
February 17, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29471442/estimation-of-adaptive-ventilation-success-and-failure-using-polysomnogram-and-outpatient-therapy-biomarkers
#2
Stacey Gunn, Sreelatha Naik, Matt Travis Bianchi, Robert Joseph Thomas
Study Objectives: Adaptive servo ventilation (ASV) devices provide anti-cyclic pressure support for treatment of central/complex sleep apnea, including in heart failure patients. Variability in responses in the clinic and negative clinical trials motivated assessment of standard and novel signal biomarkers for ASV efficacy. Methods: Multiple clinical databases were queried to assess potential signal biomarkers of ASV effectiveness, including 1) Attended laboratory adaptive ventilation titrations: 108, of which 66 had mainstream ETCO2 measurements...
February 17, 2018: Sleep
https://www.readbyqxmd.com/read/29471379/do-women-and-men-have-the-same-patterns-of-multiple-occupational-carcinogenic-exposures-results-from-a-cohort-of-cancer-patients
#3
Mélanie Bertin, Annie Thébaud-Mony, Emilie Counil
Complex exposure situations are frequent at the workplace, but few studies have characterized multiple occupational carcinogenic exposures (MOCE) and their gendered differences across jobs' characteristics. We assessed MOCE separately in male and female jobs and identified patterns of MOCE at job level. Participants (834 men and 183 women) were cancer patients recruited between March 2002 and December 2010 in the ongoing SCOP93 cohort study, Seine-Saint-Denis department, France. Job histories were collected through personal interviews, and carcinogenic exposures were assessed by a multidisciplinary expert committee using a list of 53 carcinogens...
February 17, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29471179/the-link-between-income-inequality-and-health-in-europe-adding-strength-dimensions-of-primary-care-to-the-equation
#4
Jens Detollenaere, Ann-Sophie Desmarest, Pauline Boeckxstaens, Sara Willems
Income inequality has been clearly associated with reduced population health. A body of evidence suggests that a strong primary care system may mitigate this negative association. The aim of this study is to assess the strength of the primary care system's effect on the inverse association between income inequality and health in Europe. Health is operationalised using four cross-sectional outcomes: self-rated health, life expectancy, mental well-being, and infant mortality. Strength of the primary care system is measured using the framework of the Primary Health Care Activity Monitor Europe, and income inequality by the Gini coefficient...
February 3, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29471102/high-fructose-diet-induced-metabolic-syndrome-pathophysiological-mechanism-and-treatment-by-traditional-chinese-medicine
#5
REVIEW
Ying Pan, Ling-Dong Kong
Fructose is a natural monosaccharide broadly used in modern society. Over the past few decades, epidemiological studies have demonstrated that high fructose intake is an etiological factor of metabolic syndrome (MetS). This review highlights research advances on fructose-induced MetS, especially the underlying pathophysiological mechanism as well as pharmacotherapy by traditional Chinese medicine (TCM), using the PubMed, Web of science, China National Knowledge Infrastructure, China Science and Technology Journal and Wanfang Data...
February 19, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29471063/intermolecular-interactions-determined-by-noe-build-up-in-macromolecules-from-hyperpolarized-small-molecules
#6
Chia-Hsiu Chen, Yunyi Wang, Christian Hilty
The nuclear Overhauser effect (NOE) is a primary means to characterize intermolecular interactions using modern NMR spectroscopy. Multiple experiments measured using different mixing time can be used for quantifying NOE buildup and measuring cross-relaxation rates. However, this approach using conventional multi-dimensional NMR is time consuming. Hyperpolarization by dissolution dynamic nuclear polarization (D-DNP) can generate deviations from equilibrium spin polarization by orders of magnitude, thereby enhancing signals and allowing to characterize NOE build up in real-time...
February 19, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29471048/new-innovative-method-relating-guided-surgery-to-dental-implant-placement
#7
Marie-Alix Fauroux, Marie De Boutray, Eve Malthiéry, Jacques-Henri Torres
INTRODUCTION: Companies selling dental implant guided systems mostly offer similar surgical guides. The purpose of this paper is to present an innovative guided surgery system which originality lies in its guidance device, and to report the author's experience in using this system for dental implant surgery. TECHNICAL PROTOCOL: Two parallel tubes on either side of the drilling axis guide the successive drills and the implant placement. As a result of the lateral guidance, there is no friction of the drills on the surgical guide which would damage it or contaminate the drilling hole with particles torn out from the guide...
February 19, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29471021/does-male-preference-play-a-role-in-maintaining-female-limited-polymorphism-in-a-batesian-mimetic-butterfly
#8
E L Westerman, R Letchinger, A Tenger-Trolander, D Massardo, D Palmer, M R Kronforst
Female-limited polymorphism occurs in multiple butterfly species with Batesian mimicry. While frequency-dependent selection is often argued as the driving force behind polymorphism in Batesian mimicry systems, male preference and alternative female mating strategies may also influence the maintenance of multiple female forms. Through a series of behavioural assays with the female-limited Batesian mimetic butterfly Papilio polytes, we show that males prefer stationary mimetic females over stationary non-mimetic females, but weigh female activity levels more heavily than female wing pattern when choosing between active mimetic and active non-mimetic females...
February 19, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29470992/control-of-cell-fraction-and-population-recovery-during-tissue-regeneration-in-stem-cell-lineages
#9
Marissa Renardy, Alexandra Jilkine, Leili Shahriyari, Ching-Shan Chou
Multicellular tissues are continually turning over, and homeostasis is maintained through regulated proliferation and differentiation of stem cells and progenitors. Following tissue injury, a dramatic increase in cell proliferation is commonly observed, resulting in rapid restoration of tissue size. This regulation is thought to occur via multiple feedback loops acting on cell self-renewal or differentiation. Models of ordinary differential equations have been widely used to study the cell lineage system. Prior modeling studies have suggested that loss of homeostasis and initiation of tumorigenesis can be contributed to the loss of control of these processes, and the rate of symmetric versus asymmetric division of the stem cells may also be altered...
February 19, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29470968/multiple-sclerosis-mechanisms-and-immunotherapy
#10
REVIEW
Clare Baecher-Allan, Belinda J Kaskow, Howard L Weiner
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act on a genetically susceptible host. It features three clinical stages: a pre-clinical stage detectable only by MRI; a relapsing-remitting (RRMS) stage characterized by episodes of neurologic dysfunction followed by resolution; and a progressive stage, which usually evolves from the relapsing stage. Advances in our understanding of the immune mechanisms that contribute to MS have led to more than ten FDA-approved immunotherapeutic drugs that target effector T cells, regulatory cells, B cells, and cell trafficking into the nervous system...
February 21, 2018: Neuron
https://www.readbyqxmd.com/read/29470844/reference-values-for-respiratory-impedance-measured-by-the-forced-oscillation-technique-in-adult-men-and-women
#11
Fernando Carlos Vetromille Ribeiro, Agnaldo José Lopes, Pedro Lopes de Melo
INTRODUCTION: The Forced oscillation technique (FOT) is a particularly useful test of the mechanical properties of the respiratory system that has an increasingly important role in lung function laboratories. There is general agreement in the literature that the determination of reference values is of utmost importance in the clinical use of the FOT. OBJECTIVE: Our aim was to present reference values for whole-breath FOT measurements, establish which anthropometric variables were more predictive of impedance parameters, and provide all the details to adequately adopt these reference equations in individual laboratories...
February 22, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29470821/is-eq-5d-5l-better-than-eq-5d-3l-a-head-to-head-comparison-of-descriptive-systems-and-value-sets-from-seven-countries
#12
Mathieu F Janssen, Gouke J Bonsel, Nan Luo
OBJECTIVE: This study describes the first empirical head-to-head comparison of EQ-5D-3L (3L) and EQ-5D-5L (5L) value sets for multiple countries. METHODS: A large multinational dataset, including 3L and 5L data for eight patient groups and a student cohort, was used to compare 3L versus 5L value sets for Canada, China, England/UK (5L/3L, respectively), Japan, The Netherlands, South Korea and Spain. We used distributional analyses and two methods exploring discriminatory power: relative efficiency as assessed by the F statistic, and an area under the curve for the receiver-operating characteristics approach...
February 22, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29470774/multi-indication-and-combination-pricing-and-reimbursement-of-pharmaceuticals-opportunities-for-improved-health-care-through-faster-uptake-of-new-innovations
#13
Ulf Persson, J M Norlin
Many pharmaceuticals are effective in multiple indications and the degree of effectiveness may differ. A product-based pricing and reimbursement system with a single price per product is insufficient to reflect the variable values between different indications. The objective of this article is to present examples of actual pricing and reimbursement decisions using current value-based pricing in Sweden and to discuss their implications and possible solutions. The value of several cancer drugs was estimated for various indications based on a willingness-to-pay threshold of 1 million SEK (EUR 104,000) per QALY gained...
February 22, 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29470717/risk-of-central-nervous-system-defects-in-offspring-of-women-with-and-without-mental-illness
#14
Aimina Ayoub, William D Fraser, Nancy Low, Laura Arbour, Jessica Healy-Profitós, Nathalie Auger
We sought to determine the relationship between maternal mental illness and the risk of having an infant with a central nervous system defect. We analyzed a cohort of 654,882 women aged less than 20 years between 1989 and 2013 who later delivered a live born infant in any hospital in Quebec, Canada. The primary exposure was mental illness during pregnancy or hospitalization for mental illness before pregnancy. The outcomes were neural and non-neural tube defects of the central nervous system in any offspring...
February 22, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29470704/relationship-between-sleep-and-exercise-as-colorectal-cancer-survivors-transition-off-treatment
#15
Theresa Coles, Antonia V Bennett, Xianming Tan, Claudio L Battaglini, Hanna K Sanoff, Ethan Basch, Roxanne E Jensen, Bryce B Reeve
PURPOSE: The primary objective of this study was to evaluate the relationship between exercise and sleep disturbance in a sample of individuals diagnosed with stage I, II, and III colorectal cancer (CRC) as patients transitioned off first-line treatment. We also sought to identify heterogeneity in the relationship between sleep disturbance and exercise. METHODS: Data were obtained from the MY-Health study, a community-based observational study of adults diagnosed with cancer...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29470457/hiv-diagnoses-among-persons-aged-13-29-years-united-states-2010-2014
#16
M Cheryl Bañez Ocfemia, Richard Dunville, Tianchi Zhang, Lisa C Barrios, Alexandra M Oster
In 2014, persons aged 13-29 years represented 23% of the U.S. population, yet accounted for 40% of diagnoses of human immunodeficiency virus (HIV) infection during the same year (1). During 2010-2014, the rates of diagnosis of HIV infection decreased among persons aged 15-19 years, were stable among persons aged 20-24 years, and increased among persons aged 25-29 years (1). However, these 5-year age groups encompass multiple developmental stages and potentially mask trends associated with the rapid psychosocial changes during adolescence through young adulthood...
February 23, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29470400/ramp-a-comprehensive-relational-database-of-metabolomics-pathways-for-pathway-enrichment-analysis-of-genes-and-metabolites
#17
Bofei Zhang, Senyang Hu, Elizabeth Baskin, Andrew Patt, Jalal K Siddiqui, Ewy A Mathé
The value of metabolomics in translational research is undeniable, and metabolomics data are increasingly generated in large cohorts. The functional interpretation of disease-associated metabolites though is difficult, and the biological mechanisms that underlie cell type or disease-specific metabolomics profiles are oftentimes unknown. To help fully exploit metabolomics data and to aid in its interpretation, analysis of metabolomics data with other complementary omics data, including transcriptomics, is helpful...
February 22, 2018: Metabolites
https://www.readbyqxmd.com/read/29470361/early-heterogenic-response-of-renal-microvasculature-to-hemorrhagic-shock-resuscitation-and-the-influence-of-nf-%C3%AE%C2%BAb-pathway-blockade
#18
Rui Yan, Matijs van Meurs, Eliane R Popa, Ranran Li, Peter J Zwiers, Jan G Zijlstra, Jill Moser, Grietje Molema
Hemorrhagic shock (HS) is associated with low blood pressure due to excessive loss of circulating blood and causes both macrocirculatory and microcirculatory dysfunction. Fluid resuscitation after HS is used in the clinic to restore tissue perfusion. The persistent microcirculatory damage caused by HS and/or resuscitation can result in multiple organ damage, with the kidney being one of the involved organs. The kidney microvasculature consists of different segments that possess a remarkable heterogeneity in functional properties...
February 21, 2018: Shock
https://www.readbyqxmd.com/read/29470360/oral-supplementation-with-bovine-colostrum-prevents-septic-shock-and-brain-barrier-disruption-during-bloodstream-infection-in-preterm-newborn-pigs
#19
Anders Brunse, Päivi Worsøe, Susanne Elisabeth Pors, Kerstin Skovgaard, Per Torp Sangild
Preterm infants have increased risk of neonatal sepsis, potentially inducing brain injury, and they may benefit from early initiation of enteral milk feeding. Using preterm pigs as models, we hypothesized that early provision of bovine colostrum to parentally nourished newborns protects against sepsis and neuroinflammation during bloodstream infection. Preterm newborn pigs were administered 10 CFU/kg of intra-arterial Staphylococcus epidermidis (SE, an opportunistic pathogen often causing sepsis in preterm infants), followed by administration of total parenteral nutrition (TPN, SE + TPN, n = 15) or oral provision of bovine colostrum with supplementary parenteral nutrition (SE + COL, n = 14), and compared with uninfected, TPN-nourished controls (CON + TPN, n = 11)...
February 21, 2018: Shock
https://www.readbyqxmd.com/read/29470168/evaluation-of-the-healthy-lifestyles-initiative-for-improving-community-capacity-for-childhood-obesity-prevention
#20
Marcie Berman, Frances Bozsik, Robin P Shook, Emily Meissen-Sebelius, Deborah Markenson, Shelly Summar, Emily DeWit, Jordan A Carlson
PURPOSE AND OBJECTIVES: Policy, systems, and environmental approaches are recommended for preventing childhood obesity. The objective of our study was to evaluate the Healthy Lifestyles Initiative, which aimed to strengthen community capacity for policy, systems, and environmental approaches to healthy eating and active living among children and families. INTERVENTION APPROACH: The Healthy Lifestyles Initiative was developed through a collaborative process and facilitated by community organizers at a local children's hospital...
February 22, 2018: Preventing Chronic Disease
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