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https://www.readbyqxmd.com/read/28933124/-analysis-on-pharmacokinetics-pharmacodynamics-correlation-of-effective-ingredients-of-qing-e-wan
#1
Ling Liu, Ze-Bin Weng, Heng Wang, Xing-Yu Zhu, Zhi-Peng Chen, Li Wu, Wei-Dong Li
To study the pharmacokinetics of three active ingredients in Qing'e wan, namely geniposidic acid, psoralen and isopsoralen, in rats, in order to investigate their correlation in the anti-osteoporotic effect. The rats were taken blood from their eye sockets at different time points after being orally administered with raw and salt-processed Qing'e wan. Geniposidic acid, psoralen and isopsoralen in rats plasma were determined by means of UHPLC-MS/MS to draw the concentration-time curve. The proliferation rate of osteoblasts was taken as the pharmacodynamic index, and determined by MTT method to draw effect-time curve...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28932653/a-bio-inspired-approach-for-the-design-of-a-multifunctional-robotic-end-effector-customized-for-automated-maintenance-of-a-reconfigurable-vibrating-screen
#2
O A Makinde, K Mpofu, R Vrabic, B I Ramatsetse
The development of a robotic-driven maintenance solution capable of automatically maintaining reconfigurable vibrating screen (RVS) machine when utilized in dangerous and hazardous underground mining environment has called for the design of a multifunctional robotic end-effector capable of carrying out all the maintenance tasks on the RVS machine. In view of this, the paper presents a bio-inspired approach which unfolds the design of a novel multifunctional robotic end-effector embedded with mechanical and control mechanisms capable of automatically maintaining the RVS machine...
2017: Robotics and Biomimetics
https://www.readbyqxmd.com/read/28932154/malpositioned-canine-treatment-with-autotransplantation-and-laser
#3
Serap Keskin Tunc, Mehmet Savas Kayasan, Esma Ozeroglu, Cennet Neslihan Eroglu
Children and young adults often have tooth loss due to congenital tooth deficiency, trauma, or caries. Autotransplantation has many benefits. The transplanted tooth can be moved orthodontically, maintains alveolar bone growth potential during eruption, and functional periodontal ligament function also permits tooth eruption, allows the defected areas to be filled with the bones; gingival contour is much more successful than the one obtained with prosthesis. In this paper, treatment steps and follow-up results of autotransplantation case supported with biostimulation are mentioned...
July 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28932043/gingival-mesenchymal-stem-cells
#4
Deepak Venkatesh, K P Mohan Kumar, Jyoti B Alur
The human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone. In the last year's gingival mesenchymal stem/progenitor cells (GMSCs), with promising regenerative and immunomodulatory properties, have been isolated and characterized from the gingival lamina propria. These cells, in contrast to other mesenchymal stem/progenitor cell (MSC) sources, are abundant, readily accessible and easily obtainable through minimally invasive cell isolation techniques...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28927643/a-combined-kinematic-and-kinetic-analysis-at-the-residuum-socket-interface-of-a-knee-disarticulation-amputee
#5
Jinghua Tang, Michael McGrath, Nick Hale, Liudi Jiang, Dan Bader, Piotr Laszczak, David Moser, Saeed Zahedi
The bespoke interface between a lower limb residuum and a prosthetic socket is critical for an amputee's comfort and overall rehabilitation outcomes. Analysis of interface kinematics and kinetics is important to gain full understanding of the interface biomechanics, which could aid clinical socket fit, rehabilitation and amputee care. This pilot study aims to investigate the dynamic correlation between kinematic movement and kinetic stresses at the interface during walking tests on different terrains. One male, knee disarticulation amputee participated in the study...
September 15, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28926380/osseointegrated-transtibial-implants-in-patients-with-peripheral-vascular-disease-a-multicenter-case-series-of-5-patients-with-1-year-follow-up
#6
Robin Atallah, Jiao Jiao Li, William Lu, Ruud Leijendekkers, Jan Paul Frölke, Munjed Al Muderis
BACKGROUND: Osseointegration is an alternative treatment for amputees who are unable to wear or have difficulty wearing a socket prosthesis. Although the majority of limb amputations are due to vascular disease, such amputations have been perceived as a contraindication to osseointegration surgery. We report the outcomes of osseointegrated reconstruction in a series of 5 patients with limb amputation due to peripheral vascular disease. METHODS: Five patients with transtibial amputation and a history of peripheral vascular disease who received an osseointegration implant from 2014 to 2015 were followed for 12 months...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28921659/ligature-induced-peri-implantitis-and-periodontitis-in-mice
#7
Sarah Hiyari, Ryan Wong, Aline Yaghsezian, Azadi Naghibi, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih
AIM: Peri-implantitis (PI), inflammation around dental implants, shares characteristics with periodontitis (PD). However, PI is more difficult to control, treat, and detailed pathophysiology is unclear. We aimed to compare PI and PD progression utilizing a murine model. MATERIALS AND METHODS: Four-week-old male C57BL/6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets and osseointegrated. Ligatures were tied around the implant and second molar...
September 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28918664/outcomes-of-surface-replacement-proximal-interphalangeal-joint-arthroplasty-using-the-self-locking-finger-joint-implant-minimum-two-years-follow-up
#8
Issei Komatsu, Yoshiya Arishima, Hirotomo Shibahashi, Toshihito Yamaguchi, Yoshitaka Minamikawa
BACKGROUND: The Self Locking Finger Joint (SLFJ) implant is a new type of surface replacement implant. The purpose of this study was to evaluate midterm clinical outcomes of the proximal interphalangeal (PIP) arthroplasty with the SLFJ implant. METHODS: We retrospectively studied 26 PIP joint arthroplasties using the SLFJ implant in 17 patients with osteoarthritis or posttraumatic osteoarthritis. Preoperative and postoperative range of motion, grip strength and key pinch, radiographic findings, and complications were evaluated...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28913407/early-intraprosthetic-dislocation-in-dual-mobility-implants-a%C3%A2-systematic-review
#9
Ivan De Martino, Rocco D'Apolito, Bradford S Waddell, Alexander S McLawhorn, Peter K Sculco, Thomas P Sculco
BACKGROUND: Dual mobility implants are subject to a specific implant-related complication, intraprosthetic dislocation (IPD), in which the polyethylene liner dissociates from the femoral head. For older generation designs, IPD was attributable to late polyethylene wear and subsequent failure of the head capture mechanism. However, early IPDs have been reportedly affecting contemporary designs. METHODS: A systematic review of the literature according to the preferred reporting items for systematic reviews and meta-analyses guidelines was performed...
September 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28905475/evaluation-of-volumetric-dimensional-changes-in-posterior-extraction-sites-with-and-without-arp-using-a-novel-imaging-device
#10
Carolina Sbordone, Paolo Toti, Ranieri Martuscelli, Franco Guidetti, Massimo Porzio, Ludovico Sbordone
BACKGROUND: Alveolar ridge volume loss may be minimized when postextraction sockets are filled by bone substitutes. PURPOSE: The aim of the study was to measure the effect of alveolar ridge preservation (ARP) in maintaining the external contour of the ridge after fresh socket grafting with or without particulate anorganic bovine bone mineral (BBM) and resorbable barrier covering. MATERIALS AND METHODS: In the present controlled study, patients subjected to single-tooth extraction were allocated to 2 groups: postextraction sockets grafted with bovine bone mineral (bbm), and naturally healing sockets (nat)...
September 14, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28902422/transplantation-of-non-cultured-stromal-vascular-fraction-cells-of-adipose-tissue-ameliorates-osteonecrosis-of-the-jaw-like-lesions-in-mice
#11
Shinichiro Kuroshima, Muneteru Sasaki, Kazunori Nakajima, Saki Tamaki, Hiroki Hayano, Takashi Sawase
The precise pathoetiology and effective treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) remain unknown. Transplantation of non-cultured stromal vascular fraction (SVF) cells has been demonstrated to be a useful method for regenerative medicine in place of stem cell therapy. This study investigated the effects of non-cultured SVF transplantation on tooth extraction socket healing in mice. Both chemotherapeutic/bisphosphonate combination therapy for 7 weeks and tooth extraction of maxillary first molars at 3 weeks after drug administration were performed using female C57BL/6J mice...
September 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28895779/combination-of-bone-graft-and-resorbable-membrane-for-alveolar-ridge-preservation-a-systematic-review-meta-analysis-and-trial-sequential-analysis
#12
Giuseppe Troiano, Khrystyna Zhurakivska, Lorenzo Lo Muzio, Luigi Laino, Marco Cicciù, Lucio Lo Russo
INTRODUCTION: Alveolar ridge preservation (ARP) techniques are aimed to reduce the resorption after tooth extraction. The combination of a graft material covered with a resorbable membrane represent one of the most common strategies performed in the clinical practice. The aim of this systematic review was to analyse evidence regarding potential benefits of ARP procedures performed with allogenic/xenogenic grafts in combination with a resorbable membrane coverage in comparison to a spontaneous healing...
September 12, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28885317/ridge-preservation-after-maxillary-third-molar-extraction-using-30-porosity-plga-ha-%C3%AE-tcp-scaffolds-with-and-without-simvastatin-a-pilot-randomized-controlled-clinical-trial
#13
Miguel Noronha Oliveira, Levy Hermes Rau, Aline Marodin, Márcio Corrêa, Letícia Ruhland Corrêa, Aguedo Aragones, Ricardo de Souza Magini
OBJECTIVE: To evaluate clinically and radiographically, in humans, the healing of maxillary third molars postextraction sockets after application of different ridge preservation techniques 3 months after tooth extraction. MATERIALS AND METHODS: Twenty-six sockets (13 patients) were randomly assigned to 4 treatment modalities: deproteinized bovine bone mineral with 10% collagen (DBBM-C), poly(D,L-lactide-co-glycolide) with hydroxyapatite/β-TCP scaffold (PLGA/HA), PLGA/HA/β-TCP with 2...
September 6, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28885113/a-3d-printed-surgical-analogue-to-reduce-donor-tooth-trauma-during-autotransplantation
#14
Richard R J Cousley, Andrew Gibbons, Jeremy Nayler
Surgical trauma and prolonged extra-alveolar exposure of the donor tooth's root sheath are both complicating factors during tooth autotransplantation surgery. This case report describes a 12-year-old female patient who underwent surgical transplantation of a maxillary second premolar to a central incisor site. A three-dimensional printed analogue of the donor tooth was fabricated from a cone beam (CBCT) scan of the tooth in order to minimise the extra-oral (exposure) time and frequency of trial insertions of the donor tooth into the recipient socket...
September 8, 2017: Journal of Orthodontics
https://www.readbyqxmd.com/read/28880245/evaluation-of-the-healing-potential-of-demineralized-dentin-matrix-fixed-with-recombinant-human-bone-morphogenetic-protein-2-in-bone-grafts
#15
Sang-Yun Kim, Young-Kyun Kim, Yeoung-Hyun Park, Joo-Cheol Park, Jeong-Kui Ku, In-Woong Um, Ji-Yun Kim
We aimed to evaluate the efficacy of demineralized dentin matrix (DDM) fixed with recombinant human bone morphogenetic protein-2 (rhBMP-2) through an experimental and a clinical study. Unilateral upper second and third premolars of eight beagles were extracted. A mucoperiosteal flap was elevated around the extraction socket, and a bone defect was made using a surgical drill. Each DDM was fixed with rhBMP-2, and autogenous bone was grafted at the bone defect area with a collagenous membrane. The beagles were euthanized at two, four, eight, and 12 weeks after receiving the bone graft...
September 7, 2017: Materials
https://www.readbyqxmd.com/read/28869901/transtibial-prosthetic-socket-shape-in-a-developing-country-a-study-to-compare-initial-outcomes-in-pressure-cast-hydrostatic-and-patella-tendon-bearing-designs
#16
Sheridan Laing, Noel Lythgo, Jim Lavranos, Peter Vee Sin Lee
This study compared the physical function and comfort level of patients with unilateral transtibial amputation after being fitted with a hand-cast Patella Tendon Bearing (PTB) socket and a pressure-cast (PCAST) hydrocast socket. The latter technique aims to reduce the skill dependency currently required for socket manufacture and fit. The study was conducted at the Vietnamese Training Centre for Orthopaedic Technologies and involved seventeen Vietnamese participants with unilateral transtibial amputation, all of whom were long term users of prosthetics...
August 18, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28865815/evaluation-of-the-need-for-antibiotic-prophylaxis-during-routine-intra-alveolar-dental-extractions-in-healthy-patients-a-randomized-double-blind-controlled-trial
#17
Sunil Sidana, Yusuf Mistry, Adil Gandevivala, Nitesh Motwani
OBJECTIVE: The aim of this randomized double-blind controlled trial was to evaluate the role of antibiotics in the perioperative period of dental extractions in healthy patients. METHODS: The study population included patients visiting the outpatient department of our institute. Four hundred patients were selected and randomly divided into 4 groups and underwent routine dental extraction. In group A, patients were prescribed only anti-inflammatory drugs in the postoperative period...
September 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28863119/effect-of-optic-nerve-disinsertion-during-evisceration-on-nonporous-implant-migration-a-comparative-case-series-and-a-review-of-literature
#18
Tarjani V Dave, Edak Ezeanosike, Sayan Basu, Mohammad Javed Ali, Swathi Kaliki, Milind N Naik
AIM: To determine whether evisceration with optic nerve disinsertion and nonporous implant placement increases the risk of implant migration. METHODS: This was a single-center, retrospective consecutive comparative interventional case series including patients undergoing evisceration with nonporous implant between January and December 2014. Patients were grouped into 2 groups: group I where the optic nerve was not disinserted (n = 37) and group II with optic nerve disinsertion (n = 50)...
August 23, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28862584/a-root-volume-study-of-the-adult-dentition-for-ridge-preservation-purposes
#19
John Thousand, Joseph Datar, Kerri Font, Charles A Powell
Ridge preservation has become a common practice to preserve the remaining alveolar bone volume after tooth extraction. The most common volume of graft material in commercially available vials is between 0.50 and 1.00 mL. The clinician must estimate how much grafting material is needed after extracting a tooth. The aim of this study is to provide the clinician with a volumetric guide for selection of graft material for ridge preservation after tooth extraction. Fifteen sets of permanent teeth, each representing a full adult dentition excluding the third molars, were selected at random from a collection of extracted teeth...
September 2017: General Dentistry
https://www.readbyqxmd.com/read/28861284/alveolar-socket-preservation-with-demineralised-bovine-bone-mineral-and-a-collagen-matrix
#20
Carlo Maiorana, Pier Paolo Poli, Matteo Deflorian, Tiziano Testori, Federico Mandelli, Heiner Nagursky, Raffaele Vinci
PURPOSE: The aim of the present study was to evaluate the healing of post-extraction sockets following alveolar ridge preservation clinically, radiologically, and histologically. METHODS: Overall, 7 extraction sockets in 7 patients were grafted with demineralised bovine bone mineral and covered with a porcine-derived non-crosslinked collagen matrix (CM). Soft tissue healing was clinically evaluated on the basis of a specific healing index. Horizontal and vertical ridge dimensional changes were assessed clinically and radiographically at baseline and 6 months after implant placement...
August 2017: Journal of Periodontal & Implant Science
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