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Exercise, type-1 diabetes

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https://www.readbyqxmd.com/read/28230765/metabolic-effects-of-glucose-fructose-co-ingestion-compared-to-glucose-alone-during-exercise-in-type-1-diabetes
#1
Lia Bally, Patrick Kempf, Thomas Zueger, Christian Speck, Nicola Pasi, Carlos Ciller, Katrin Feller, Hannah Loher, Robin Rosset, Matthias Wilhelm, Chris Boesch, Tania Buehler, Ayse S Dokumaci, Luc Tappy, Christoph Stettler
This paper aims to compare the metabolic effects of glucose-fructose co-ingestion (GLUFRU) with glucose alone (GLU) in exercising individuals with type 1 diabetes mellitus. Fifteen male individuals with type 1 diabetes (HbA1c 7.0% ± 0.6% (53 ± 7 mmol/mol)) underwent a 90 min iso-energetic continuous cycling session at 50% VO2max while ingesting combined glucose-fructose (GLUFRU) or glucose alone (GLU) to maintain stable glycaemia without insulin adjustment. GLUFRU and GLU were labelled with (13)C-fructose and (13)C-glucose, respectively...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28229636/exercise-partially-reverses-the-inhibitory-effect-of-caffeine-on-liver-gluconeogenesis-in-type-1-diabetic-rats-with-hypoglycemia
#2
E H Gilglioni, C M Ghuidotti, V R Vilela, C Bataglini, J P Furlan, J A Berti, Mmd Pedrosa, Vaf Godoi
The purpose was to determine the possible effects of exercise and/or caffeine on hypoglycemia and liver gluconeogenesis in diabetic rats. These were divided into four subgroups: (a) intraperitoneal insulin only, (b) exercise bout before insulin, (c) caffeine after insulin, and (d) exercise bout before and caffeine after insulin. The marked glycemic drop 45 min after insulin (0 min = 229.00, 45 min = 75.75) was considerably reduced (p < 0.05) by caffeine or exercise (45 min: exercise = 127...
September 2016: Physiol Int
https://www.readbyqxmd.com/read/28226972/design-of-a-dual-hormone-model-predictive-control-for-artificial-pancreas-with-exercise-model
#3
Navid Resalat, Joseph El Youssef, Ravi Reddy, Peter G Jacobs, Navid Resalat, Joseph El Youssef, Ravi Reddy, Peter G Jacobs, Navid Resalat, Joseph El Youssef, Peter G Jacobs, Ravi Reddy
The Artificial Pancreas (AP) is a new technology for helping people with type 1 diabetes to better control their glucose levels through automated delivery of insulin and optionally glucagon in response to sensed glucose levels. In a dual hormone AP, insulin and glucagon are delivered automatically to the body based on glucose sensor measurements using a control algorithm that calculates the amount of hormones to be infused. A dual-hormone MPC may deliver insulin continuously; however, it must avoid continuous delivery of glucagon because nausea can occur from too much glucagon...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28212346/the-relationship-between-physical-activity-and-plasma-glucose-level-amongst-ellisras-rural-young-adult-males-and-females-ellisras-longitudinal-study
#4
Moloko Matshipi, Kotsedi Daniel Monyeki, Han Kemper
Unhealthy lifestyle characteristics such as low physical activity (PA) and high plasma glucose levels (PGLs) may lead to the development of type 2 diabetes mellitus in adulthood. The aim of this study was to investigate (i) the level of physical activity; (ii) the prevalence of pre-diabetes and (iii) the relationship between PA and plasma glucose level in a rural Ellisras adult population aged 18 to 28 years. A total of 713 young adults (349 males and 364 females) who took part in the Ellisras Longitudinal Study participated in the study...
February 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28210986/the-role-of-the-pharmacist-in-managing-type-2-diabetes-with-glucagon-like-peptide-1-receptor-agonists-as-add-on-therapy
#5
REVIEW
Jerry Meece
: The prevalence and associated clinical burden of type 2 diabetes (T2D) is increasing in the USA and other countries. As a consequence, the role of the pharmacist in managing T2D is expanding, and it is becoming increasingly important for pharmacists to have a complete understanding of the disease course and treatment options. Pharmacists have a key role in the use of injectable therapies, including incretin-based treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs). This article discusses the role of the pharmacist in the management of patients with T2D, particularly with respect to the use of GLP-1RAs to achieve glycemic control...
February 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28210043/repeated-3-minute-stair-climbing-descending-exercise-after-a-meal-over-2-weeks-increases-serum-1-5-anhydroglucitol-levels-in-people-with-type-2-diabetes
#6
Hiroto Honda, Makoto Igaki, Yuki Hatanaka, Motoaki Komatsu, Shin-Ichiro Tanaka, Tetsuo Miki, Yumika Matsuki, Tetsuo Takaishi, Tatsuya Hayashi
[Purpose] The purpose of this study was to examine the hypoglycemic effect of a postprandial exercise program using brief stair climbing-descending exercise in people with type 2 diabetes. [Subjects and Methods] Seven males with uncomplicated type 2 diabetes (age 68.0 ± 3.7 years) performed two sets of stair climbing-descending exercise 60 and 120 min after each meal for the first 2 weeks but not for the following 2 weeks. Each set of exercise comprised 3-min of continuous repetition of climbing briskly to the second floor followed by slow waking down to the first floor in their home...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28209386/dietary-therapy-in-heart-failure-with-preserved-ejection-fraction-and-or-left-ventricular-diastolic-dysfunction-in-patients-with-metabolic-syndrome
#7
REVIEW
Helene von Bibra, Alexander Ströhle, Martin St John Sutton, Nicolai Worm
BACKGROUND: Heart failure is an ongoing epidemic of left ventricular (LV) dilatation and/or dysfunction due to the increasing prevalence of predisposing risk factors such as age, physical inactivity, (abdominal) obesity, and type-2-diabetes. Approximately half of these patients have diastolic heart failure (HFpEF). The prognosis of HFpEF is comparable to that of systolic heart failure, but without any known effective treatment. DIASTOLIC DYSFUNCTION: A biomathematically corrected diagnostic approach is presented that quantifies diastolic dysfunction via the predominant age dependency of LV diastolic function and unmasks (metabolic) risk factors, that are independent of age and, therefore, potential targets for therapy...
January 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28208021/exercise-timing-and-blood-lactate-concentrations-in-individuals-with-type-2-diabetes
#8
Timothy D Heden, Ying Liu, Jill A Kanaley
The purpose of this study was to characterize how resistance exercise prior to or after a meal alters fasting and postprandial blood lactate concentrations in individuals with type 2 diabetes. Obese individuals with type 2 diabetes (N=12) completed three, 2-d trials including: 1) no exercise (NoEx), 2) resistance exercise prior to dinner (Ex-M), and 3) resistance exercise beginning 45-min postdinner (M-Ex). During day one of each trial fasting and postprandial blood lactate concentrations, perceived exertion, and substrate oxidation were measured, and subsequently on day two the following morning fasting blood lactate was measured...
February 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28205324/evaluation-of-subcutaneous-glucose-monitoring-systems-under-routine-environmental-conditions-in-patients-with-type-1-diabetes
#9
Felix Aberer, Martin Hajnsek, Markus Rumpler, Sabine Zenz, Petra Baumann, Hesham Elsayed, Adelheid Puffing, Gerlies Treiber, Thomas R Pieber, Harald Sourij, Julia K Mader
: Continuous and flash glucose monitoring (GM) systems have been established in diabetes care. We compared sensor performance of three commercially available GM systems. 12 patients with type 1 diabetes were included in a single-centre, open-label study where sensor performance of Abbott FreeStyle libre (Abbott), Dexcom G4 Platinum (Dexcom) and Medtronic MiniMed 640G (Medtronic) over 12 hours was compared during mimicked real-life conditions (meals, exercise, hypo- and hyperglycaemia)...
February 16, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28191913/treatment-with-the-glucagon-receptor-antagonist-ly2409021-increases-ambulatory-blood-pressure-in-patients-with-type-2-diabetes
#10
Christof M Kazda, Juan Frias, Irene Foga, Xuewei Cui, Cristina B Guzman, Parag Garhyan, Cory Heilmann, Jihui Anne Yang, Thomas A Hardy
AIMS: To assess the effect of LY2409021 on systolic blood pressure (SBP) in patients with type 2 diabetes. MATERIALS AND METHODS: This 6-week, randomized, crossover study evaluated the effects of once-daily administration of LY2409021 20 mg vs those of placebo on SBP, diastolic BP (DBP), and mean arterial pressure (MAP) using 24-hour ambulatory BP monitoring (ABPM) in 270 subjects treated with diet/exercise ± metformin. Other measures included changes in glycemic control, serum lipids, and hepatic safety markers...
February 13, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28188972/effect-of-exercise-combined-with-glucagon-like-peptide-1-receptor-agonist-treatment-on-cardiac-function-a-randomised-double-blinded-placebo-controlled-clinical-trial
#11
Peter G Jørgensen, Magnus T Jensen, Pernille Mensberg, Heidi Storgaard, Signe Nyby, Jan S Jensen, Filip K Knop, Tina Vilsbøll
In patients with type 2 diabetes, both supervised exercise and treatment with the glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) liraglutide may improve cardiac function. We evaluated cardiac function before and after 16 weeks of treatment with the GLP-1RA liraglutide or placebo combined with supervised exercise in 33 dysregulated patients with type 2 diabetes on diet and/or metformin. Early diastolic myocardial tissue velocity was improved by exercise in the placebo group (-7.1 ± 1.6 cm/s (mean ± standard deviation) to -7...
February 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28185715/effects-of-oral-antidiabetic-drugs-on-changes-in-the-liver-to-spleen-ratio-on-computed-tomography-and-inflammatory-biomarkers-in-patients-with-type-2-diabetes-and-nonalcoholic-fatty-liver-disease
#12
Koichi Yabiku, Akiko Mutoh, Kazufumi Miyagi, Nobuyuki Takasu
PURPOSE: Oral antidiabetic drugs (OADs) such as pioglitazone and metformin have beneficial effects in patients with nonalcoholic steatohepatitis. We prospectively assessed the effects of OADs on nonalcoholic fatty liver disease (NAFLD) in 886 men with type 2 diabetes mellitus and in a murine model of NAFLD. METHODS: Patients were randomized to receive pioglitazone, metformin, sitagliptin, or a non-OAD (control) for 6 months. All the patients received dietary and exercise guidance once a month during this study...
February 6, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28178985/behaviour-change-techniques-targeting-both-diet-and-physical-activity-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#13
REVIEW
Kevin A Cradock, Gearóid ÓLaighin, Francis M Finucane, Heather L Gainforth, Leo R Quinlan, Kathleen A Martin Ginis
BACKGROUND: Changing diet and physical activity behaviour is one of the cornerstones of type 2 diabetes treatment, but changing behaviour is challenging. The objective of this study was to identify behaviour change techniques (BCTs) and intervention features of dietary and physical activity interventions for patients with type 2 diabetes that are associated with changes in HbA1c and body weight. METHODS: We performed a systematic review of papers published between 1975-2015 describing randomised controlled trials (RCTs) that focused exclusively on both diet and physical activity...
February 8, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28168767/lifestyle-change-reduces-cardiometabolic-risk-factors-and-glucagon-like-peptide-1-levels-in-obese-first-degree-relatives-of-people-with-diabetes
#14
A Bowes, J Begley, D Kerr
BACKGROUND: Preventing type 2 diabetes in a real-world setting remains challenging. The present study aimed to assess the effectiveness of a lifestyle-based programme for individuals at high risk of developing type 2 diabetes as assessed by achieved weight loss, cardiovascular risk factors and glucagon-like peptide-1 (GLP-1). METHODS: Sixty-six obese individuals with history of diabetes in first-degree relatives participated in an 8-month lifestyle programme consisting of 12 × 1...
February 7, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28160083/high-intensity-aerobic-interval-training-improves-aerobic-fitness-and-hba1c-among-persons-diagnosed-with-type-2-diabetes
#15
Eva Maria Støa, Sondre Meling, Lill-Katrin Nyhus, Glenn Strømstad, Karl Magnus Mangerud, Jan Helgerud, Solfrid Bratland-Sanda, Øyvind Støren
PURPOSE: It remains to be established how high-intensity aerobic interval training (HAIT) affects risk factors associated with type 2 diabetes (TD2). This study investigated effects of HAIT on maximal oxygen uptake (VO2max), glycated Hemoglobin type A1C (HbA1c), insulin resistance (IR), fat oxidation (FatOx), body weight (BW), percent body fat (%BF), lactate threshold (LT), blood pressure (BP), and blood lipid profile (BLP) among persons with T2D. Results were compared to the effects after a moderate-intensity training (MIT) program...
February 3, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28155245/scriptaid-enhances-skeletal-muscle-insulin-action-and-cardiac-function-in-obese-mice
#16
Vidhi Gaur, Timothy Connor, Kylie Venardos, Darren C Henstridge, Sheree D Martin, Courtney Swinton, Shona Morrison, Kathryn Aston-Mourney, Stefan M Gehrig, Roelof van Ewijk, Gordon S Lynch, Mark A Febbraio, Gregory R Steinberg, Mark Hargreaves, Ken R Walder, Sean L McGee
AIMS/HYPOTHESIS: Current drugs used to treat metabolic diseases such as obesity and type 2 diabetes have limited efficacy in directly normalising muscle insulin action, while exercise is effective in enhancing this aspect of metabolic disease. We recently identified Scriptaid as a compound that can replicate aspects of the exercise adaptive response, through disruption of the class IIa HDAC corepressor complex. The Aim of this study was to determine the effect of Scriptaid on muscle insulin action in obesity...
February 2, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28153817/searching-for-real-world-effectiveness-of-health-care-innovations-scoping-study-of-social-prescribing-for-diabetes
#17
Karen Pilkington, Martin Loef, Marie Polley
BACKGROUND: Social prescribing is a process whereby primary care patients are linked or referred to nonmedical sources of support in the community and voluntary sector. It is a concept that has arisen in practice and implemented widely in the United Kingdom and has been evaluated by various organizations. OBJECTIVE: The aim of our study was to characterize, collate, and analyze the evidence from evaluation of social prescribing for type 2 diabetes in the United Kingdom and Ireland, comparing information available on publicly available websites with the published literature...
February 2, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28144460/the-effect-of-aerobic-exercise-training-on-plasma-apelin-levels-and-pain-threshold-in-t1dm-rats
#18
Reza Delavar, Ali Heidarianpour
BACKGROUND: Diabetes mellitus (types 1 and 2) leads to secondary complications such as neuropathy, which reduce a patient's quality of life. Apelin and its receptor, APJ, have been shown to have antinociceptive effects and to decrease blood glucose levels. OBJECTIVES: The present experimental study was conducted in Iran and investigated the role of apelin, which is used to manage type 1 diabetes mellitus, during exercise training. MATERIALS AND METHODS: Male Wistar rats (n = 36) were assigned by simple random allocation to six groups (n = 6): non-diabetic (ND), diabetic (D), sedentary non-diabetic (SND), sedentary diabetic (SD), exercise non-diabetic (END), and exercise diabetic (ED)...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28126459/exercise-management-in-type-1-diabetes-a-consensus-statement
#19
REVIEW
Michael C Riddell, Ian W Gallen, Carmel E Smart, Craig E Taplin, Peter Adolfsson, Alistair N Lumb, Aaron Kowalski, Remi Rabasa-Lhoret, Rory J McCrimmon, Carin Hume, Francesca Annan, Paul A Fournier, Claudia Graham, Bruce Bode, Pietro Galassetti, Timothy W Jones, Iñigo San Millán, Tim Heise, Anne L Peters, Andreas Petz, Lori M Laffel
Type 1 diabetes is a challenging condition to manage for various physiological and behavioural reasons. Regular exercise is important, but management of different forms of physical activity is particularly difficult for both the individual with type 1 diabetes and the health-care provider. People with type 1 diabetes tend to be at least as inactive as the general population, with a large percentage of individuals not maintaining a healthy body mass nor achieving the minimum amount of moderate to vigorous aerobic activity per week...
January 23, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28122717/acute-high-intensity-interval-exercise-reduces-human-monocyte-toll-like-receptor-2-expression-in-type-2-diabetes
#20
Cody Durrer, Monique Emily Francois, Helena Neudorf, Jonathan Peter Little
: Type 2 diabetes (T2D) is characterized by chronic low-grade inflammation that contributes to disease pathophysiology. Exercise has anti-inflammatory effects but the impact of high-intensity interval training (HIIT) is not known. PURPOSE: To determine the impact of a single session of HIIT on cellular, molecular, and circulating markers of inflammation in individuals with T2D. METHODS: Participants with T2D (n=10) and healthy age-matched controls (HC; n=9) completed an acute bout of HIIT (7 X 1-min @ ~85% maximal aerobic power output, separated by 1-min recovery) on a cycle ergometer with blood samples obtained before (Pre), immediately after (Post), and at one-hour of recovery (1-h Post)...
January 25, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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