keyword
https://read.qxmd.com/read/38547044/construction-and-analysis-of-a-network-of-exercise-induced-mitochondria-related-non-coding-rna-in-the-regulation-of-diabetic-cardiomyopathy
#1
JOURNAL ARTICLE
Shuo Wang, Jiacong Li, Yungang Zhao
Diabetic cardiomyopathy (DCM) is a major factor in the development of heart failure. Mitochondria play a crucial role in regulating insulin resistance, oxidative stress, and inflammation, which affect the progression of DCM. Regular exercise can induce altered non-coding RNA (ncRNA) expression, which subsequently affects gene expression and protein function. The mechanism of exercise-induced mitochondrial-related non-coding RNA network in the regulation of DCM remains unclear. This study seeks to construct an innovative exercise-induced mitochondrial-related ncRNA network...
2024: PloS One
https://read.qxmd.com/read/38545661/cyclooxygenase-products-contribute-to-the-exaggerated-exercise-pressor-reflex-evoked-by-static-muscle-contraction-in-male-ucd-type-2-diabetes-mellitus-rats
#2
JOURNAL ARTICLE
Milena Samora, Yu Huo, Kimber L Stanhope, Peter J Havel, Marc P Kaufman, Michelle L Harrison, Audrey J Stone
Cyclooxygenase (COX) products of arachidonic acid metabolism, specifically prostaglandins, play a role in evoking and transmitting the exercise pressor reflex in health and disease. Individuals with type 2 diabetes mellitus (T2DM) have an exaggerated exercise pressor reflex; however, the mechanisms for this exaggerated reflex are not fully understood. We aimed to determine the role played by COX products in the exaggerated exercise pressor reflex in T2DM rats. The exercise pressor reflex was evoked by static muscle contraction in unanesthetized, decerebrate, male, adult UCD-T2DM (n=8) and healthy Sprague-Dawley (n=8) rats...
March 28, 2024: Journal of Applied Physiology
https://read.qxmd.com/read/38536038/impaired-muscle-oxygenation-despite-normal-pulmonary-function-in-uncomplicated-type-2-diabetes
#3
JOURNAL ARTICLE
Islem Jlali, Imen Touil, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Omar Hammouda, Elsa Heyman, Pierre Fontaine, Hamdi Chtourou, Remi Rabasa-Lhoret, Georges Baquet, Semah Tagougui
Long-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38531890/highlighting-the-effects-of-high-intensity-interval-training-on-the-changes-associated-with-hypertrophy-apoptosis-and-histological-proteins-of-the-heart-of-old-rats-with-type-2-diabetes
#4
JOURNAL ARTICLE
Mohammad Rami, Amirhossein Ahmadi Hekmatikar, Samaneh Rahdar, Sayed Shafa Marashi, D Maryama Awang Daud
T2DM is known to cause disturbances in glucose homeostasis and negative changes in the heart muscle, while aging and diabetes are recognized risk factors for CVD. Given this, our study aims to investigate a method for controlling and managing CVDs induced by T2DM in elderly populations. To achieve this, we categorized 40 rats into 5 groups, including HAD (n = 8), HA (n = 8), AD (n = 8), AHT (n = 8), and ADT (n = 8). The exercise protocol consisted of eight weeks of HIIT (three sessions per week) performed at 90-95% of maximal speed...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38528818/the-effect-of-glucagon-like-peptide-1-receptor-agonists-on-cardiac-function-and-structure-in-patients-with-or-without-type-2-diabetes-mellitus-an-updated-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Yu Zhang, Danning Yang, Qiufeng Jia, Jie Yan, Fengshuang An
AIMS: To conduct an updated systematic review and meta-analysis to evaluate the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1RAs) with regard to cardiac function and structure in people with or without type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: We conducted a systematic search using the PubMed, Embase and ClinicalTrials.gov online databases. The primary outcome of interest was changes in mitral inflow E-velocity to tissue Doppler e' velocity (E/e') ratio...
March 26, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38527636/the-effect-of-a-combined-lifestyle-intervention-with-and-without-protein-drink-on-inflammation-in-older-adults-with-obesity-and-type-2-diabetes
#6
JOURNAL ARTICLE
Robert G Memelink, Rose Njemini, Minse J J de Bos Kuil, Suzan Wopereis, Johan de Vogel-van den Bosch, Josje D Schoufour, Michael Tieland, Peter J M Weijs, Ivan Bautmans
BACKGROUND: Chronic low-grade inflammatory profile (CLIP) is one of the pathways involved in type 2 diabetes (T2D). Currently, there is limited evidence for ameliorating effects of combined lifestyle interventions on CLIP in type 2 diabetes. We investigated whether a 13-week combined lifestyle intervention, using hypocaloric diet and resistance exercise plus high-intensity interval training with or without consumption of a protein drink, affected CLIP in older adults with T2D. METHODS: In this post-hoc analysis of the PROBE study 114 adults (≥55 years) with obesity and type 2 (pre-)diabetes had measurements of C-reactive protein (CRP), pro-inflammatory cytokines interleukin (IL)-6, tumor-necrosis-factor (TNF)-α, and monocyte chemoattractant protein (MCP)-1, anti-inflammatory cytokines IL-10, IL-1 receptor antagonist (RA), and soluble tumor-necrosis-factor receptor (sTNFR)1, adipokines leptin and adiponectin, and glycation biomarkers carboxymethyl-lysine (CML) and soluble receptor for advanced glycation end products (sRAGE) from fasting blood samples...
March 23, 2024: Experimental Gerontology
https://read.qxmd.com/read/38527395/relationship-of-microvascular-complications-and-healthy-lifestyle-with-all-cause-and-cardiovascular-mortality-in-women-compared-with-men-with-type-2-diabetes
#7
JOURNAL ARTICLE
Yu-Jie Liu, Fu-Rong Li, Wen-Wen Han, Yan Liu, Yu Liu, Jia-Min Wang, Meng-Yuan Miao, Jie-Qiong Lyu, Zhong-Xiao Wan, Li-Qiang Qin, Guo-Chong Chen
BACKGROUND: Sex differences exist in the prevalence of microvascular disease (MVD) and healthy-lifestyle adherence. Whether MVD and healthy lifestyles are associated with mortality risk similarly for women and men who have type 2 diabetes mellitus (T2DM) remains unknown. METHODS: The present study included 9992 women and 15,860 men with T2DM from the UK Biobank. MVDs included retinopathy, peripheral neuropathy, and chronic kidney disease. Healthy lifestyle factors consisted of ideal BMI, nonsmoking, healthy diet, regular exercise, and appropriate sleep duration...
March 20, 2024: Clinical Nutrition
https://read.qxmd.com/read/38523172/effects-of-bariatric-surgery-on-sarcopenic-obesity-outcomes-a-one-year-prospective-study-in-middle-aged-women
#8
JOURNAL ARTICLE
Pietra S Rodrigues, Fernando M Mendonça, João S Neves, Carla Luís, Ilda Rodrigues, Telma Moreno, Diana Festas, Jorge Pedro, Ana Varela, Ana Fernandes, Eduardo L Costa, Paula Freitas
INTRODUCTION: Sarcopenic obesity (SO) is characterised by the confluence of muscle deterioration and high adiposity. When non-surgical interventions prove insufficient, bariatric surgery (BS) becomes the primary approach. This study aimed to address BS effects on SO outcomes 1 year post-surgery among middle-aged women, also considering physical exercise's impact. METHODS: Prospective single-centre study of 140 patients who underwent Roux-en-Y gastric bypass or sleeve gastrectomy between November 2019 and December 2022...
March 25, 2024: Obesity Surgery
https://read.qxmd.com/read/38513989/continuous-moderate-and-intermittent-high-intensity-exercise-in-youth-with-type-1-diabetes-which-protection-for-dysglycemia
#9
JOURNAL ARTICLE
Cassandra Parent, Elodie Lespagnol, Serge Berthoin, Sémah Tagougui, Chantal Stuckens, Cajsa Tonoli, Michelle Dupire, Aline Dewaele, Julie Dereumetz, Chloé Dewast, Iva Gueorgieva, Rémi Rabasa-Lhoret, Elsa Heyman
AIM: From an early age, exercise is key to managing type 1 diabetes (T1D). However, hypoglycemia around aerobic exercise is a major barrier to physical activity in children. We explore whether intermittent high-intensity aerobic exercise (IHE), designed to mimic spontaneous childhood physical activity patterns, offers better protection against glycemic drop than continuous moderate-intensity exercise (CME). METHODS: Five boys and 7 girls with T1D (9.8 ± 1...
March 19, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38513367/high-intensity-interval-training-combining-rowing-and-cycling-improves-but-does-not-restore-beta-cell-function-in-type-2-diabetes
#10
JOURNAL ARTICLE
Maria Houborg Petersen, Jacob Volmer Stidsen, Martin Eisemann de Almeida, Emil Kleis Wentorf, Kurt Jensen, Niels Ørtenblad, Kurt Højlund
AIMS: We investigated whether a high-intensity interval training (HIIT)-protocol could restore beta-cell function in type 2 diabetes compared with sedentary obese and lean individuals. MATERIALS AND METHODS: In patients with type 2 diabetes, and age-matched, glucose-tolerant obese and lean controls, we examined the effect of 8-weeks of supervised HIIT combining rowing and cycling on the acute (first-phase) and second-phase insulin responses, beta-cell function adjusted for insulin sensitivity (disposition index) and serum free fatty acid (FFA) levels using the Botnia clamp (1-h IVGTT followed by 3-h hyperinsulinemic-euglycemic clamp)...
March 1, 2024: Endocrine Connections
https://read.qxmd.com/read/38512333/effectiveness-of-a-smartphone-app-to-promote-physical-activity-among-persons-with-type-2-diabetes-randomized-controlled-trial
#11
JOURNAL ARTICLE
Stephanie E Bonn, Madeleine Hummel, Giulia Peveri, Helén Eke, Christina Alexandrou, Rino Bellocco, Marie Löf, Ylva Trolle Lagerros
BACKGROUND: Physical activity is well known to have beneficial effects on glycemic control and to reduce risk factors for cardiovascular disease in persons with type 2 diabetes. Yet, successful implementation of lifestyle interventions targeting physical activity in primary care has shown to be difficult. Smartphone apps may provide useful tools to support physical activity. The DiaCert app was specifically designed for integration into primary care and is an automated mobile health (mHealth) solution promoting daily walking...
March 21, 2024: Interactive Journal of Medical Research
https://read.qxmd.com/read/38511400/gut-hormones-and-appetite-regulation
#12
JOURNAL ARTICLE
So-Hyeon Hong, Kyung Mook Choi
PURPOSE OF REVIEW: Various gut hormones interact with the brain through delicate communication, thereby influencing appetite and subsequent changes in body weight. This review summarizes the effects of gut hormones on appetite, with a focus on recent research. RECENT FINDINGS: Ghrelin is known as an orexigenic hormone, whereas glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), cholecystokinin (CCK), postprandial peptide YY (PYY), and oxyntomodulin (OXM) are known as anorexigenic hormones...
March 22, 2024: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/38510054/exercise-training-improves-diabetic-renal-injury-by-reducing-fetuin-a-oxidative-stress-and-inflammation-in-type-2-diabetic-rats
#13
JOURNAL ARTICLE
Shadan Saberi, Majid Askaripour, Mohammad Khaksari, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Mohammad Akhbari, Elham Jafari, Kayvan Khoramipour
BACKGROUND: Diabetic kidney disease (DKD) stands as a primary contributor to end-stage renal disease, associated with heightened mortality in cardiovascular diseases. This study aimed to explore the impact of an eight-week high-intensity interval training (HIIT) on renal injury in diabetic rats. METHODS: Twenty-eight male Wistar rats were randomly allocated into four groups: healthy control (CTL), diabetic control (DC), exercise (EX), and diabetes-exercise (D + EX)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38503670/a-non-invasive-nomogram-for-predicting-heart-failure-with-preserved-ejection-fraction-in-taiwanese-outpatients-with-unexplained-dyspnea-and-fatigue
#14
JOURNAL ARTICLE
Yi-Wei Chung, Jen-Fang Cheng, Yen-Liang Lin, Hung-Jui Chuang, Chia-Chuan Chuang, Cheng-Wei Chen, Wei-Ming Huang, Cho-Kai Wu, Lian-Yu Lin
BACKGROUND: While Reddy proposed the H2FPEF diagnostic algorithm to aid in diagnosing heart failure with preserved ejection fraction (HFpEF), certain parameters like age and obesity are not suitable for Asian population, especially given the increasing incidence of HFpEF in younger individuals. Therefore, this study aimed to develop an easy-to-use nomogram with non-invasive indices that can be used in outpatient clinics in Taiwan to quickly estimate the probability of HFpEF and help decide whether further invasive cardiopulmonary exercise test (CPET) is needed...
March 18, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38502241/associations-between-daily-step-count-classifications-and-continuous-glucose-monitoring-metrics-in-adults-with-type-1-diabetes-analysis-of-the-type-1-diabetes-exercise-initiative-t1dexi-cohort
#15
JOURNAL ARTICLE
Lauren V Turner, Martin Chase Marak, Robin L Gal, Peter Calhoun, Zoey Li, Peter G Jacobs, Mark A Clements, Corby K Martin, Francis J Doyle, Susana R Patton, Jessica R Castle, Melanie B Gillingham, Roy W Beck, Michael R Rickels, Michael C Riddell
AIMS/HYPOTHESIS: Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence of daily step counts on continuous glucose monitoring (CGM) metrics are unclear. This analysis used the Type 1 Diabetes Exercise Initiative (T1DEXI) dataset to investigate the effect of daily step count on CGM-based metrics. METHODS: In a 4 week free-living observational study of adults with type 1 diabetes, with available CGM and step count data, we categorised participants into three groups-below (<7000), meeting (7000-10,000) or exceeding (>10,000) the daily step count goal-to determine if step count category influenced CGM metrics, including per cent time in range (TIR: 3...
March 19, 2024: Diabetologia
https://read.qxmd.com/read/38500351/new-insights-into-nanomedicines-for-oral-delivery-of-glucagon-like-peptide-1-analogs
#16
REVIEW
Soraia Filipa Tavares Pinto, Hélder Almeida Santos, Bruno Filipe Carmelino Cardoso Sarmento
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that arises when the body cannot respond fully to insulin, leading to impaired glucose tolerance. Currently, the treatment embraces non-pharmacological actions (e.g., diet and exercise) co-associated with the administration of antidiabetic drugs. Metformin is the first-line treatment for T2DM; nevertheless, alternative therapeutic strategies involving glucagon-like peptide-1 (GLP-1) analogs have been explored for managing the disease. GLP-1 analogs trigger insulin secretion and suppress glucagon release in a glucose-dependent manner thereby, reducing the risk of hyperglycemia...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/38497881/metabolic-control-level-and-glucose-variability-in-adolescents-with-type-1-diabetes-during-low-and-high-intensity-exercise
#17
JOURNAL ARTICLE
M Skalska, A Myśliwiec, A Michalak, J Chrzanowski, A Lejk, J Jastrzębska, Ł Radzimiński, G F Lopez-Sanchez, K Myśliwiec, Z Jastrzębski, K Weiss, B Knechtle
OBJECTIVE: The main purpose of this study was to characterize the determinants of metabolic changes in young type 1 diabetes (T1DM) and to determine glycemic variability during low and high-intensity exercise. PATIENTS AND METHODS: 20 young male T1DM patients were divided into two subgroups characterized by levels of glycated hemoglobin (HbA1c): HbA1c<7.3% (better HbA1c subgroup, n=10) and with levels HbA1c>7.3% (worse HbA1c subgroup, n=10). All participants performed a maximal oxygen uptake test and two efforts of various intensities (45 minutes of aerobic exercise and 30 minutes of mixed aerobic-anaerobic intensity exercise)...
March 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38494538/aerobic-training-with-moderate-or-high-doses-of-vitamin-d-improve-liver-enzymes-lxr%C3%AE-and-pgc-1%C3%AE-levels-in-rats-with-t2dm
#18
JOURNAL ARTICLE
Zahra Hoseini, Nasser Behpour, Rastegar Hoseini
Dysregulation of key transcription factors involved in hepatic energy metabolism, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and liver X receptor alpha (LXRα), has been observed in T2DM. The present study aims to investigate the effects of aerobic training and vitamin D supplementation on liver enzyme levels and the levels of PGC-1α and LXRα proteins in hepatocytes, in a rat model of T2DM. The study involved 56 male Wistar rats, divided into two groups: one was non-diabetic and acted as a control group (n = 8), and the other had induced diabetes (n = 48)...
March 17, 2024: Scientific Reports
https://read.qxmd.com/read/38493812/irisin-delays-the-onset-of-type-1-diabetes-in-nod-mice-by-enhancing-intestinal-barrier
#19
JOURNAL ARTICLE
Yujing Sun, Yilin Wang, Ziang Lin, Fuhua Zhang, Yan Zhang, Tongxin Ren, LiNa Wang, Qincheng Qiao, Mengyang Shen, Juncheng Wang, Youchen Song, Yu Sun, Peng Lin
Type 1 diabetes (T1D), a complex autoimmune disease, is intricately linked to the gut's epithelial barrier function. Emerging evidence emphasizes the role of irisin, an exercise-related hormone, in preserving intestinal integrity. This study investigates whether irisin could delay T1D onset by enhancing the colon intestinal barrier. Impaired colon intestinal barriers were observed in newly diagnosed T1D patients and non-obese diabetic (NOD) mice, worsening with age and accompanied by islet inflammation. Using an LPS-induced colonic inflammation model, a dose-dependent impact of LPS on colon cells irisin expression, secretion, and barrier function was revealed...
March 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38492549/association-of-aerobic-and-muscle-strengthening-physical-activity-with-all-cause-and-cardiovascular-disease-mortality-among-adults-with-type-2-diabetes-a-prospective-cohort-of-us-adults
#20
JOURNAL ARTICLE
Jiehua Wei, Luying Fan, Fan Xia, Xidi Zhu, Lizhang Chen, Tingting Wang
OBJECTIVE: To investigate the relationship of moderate physical activity (MPA), vigorous physical activity (VPA), and muscle strengthening activity (MSA), independently and jointly, with all-cause, cardiovascular disease (CVD), and non-CVD mortality in individuals with type 2 diabetes (T2D). MATERIAL AND METHODS: This cohort study included 47,538 adults with T2D and 561,963 adults without T2D from the National Health Interview Survey 1997-2018 who provided data on self-reported physical activity (PA)...
March 13, 2024: Diabetes & Metabolic Syndrome
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