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Exercise, type-1 diabetes

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https://www.readbyqxmd.com/read/28444660/effects-of-cycling-and-exergaming-on-neurotrophic-factors-in-elderly-type-2-diabetic-men-a-preliminary-investigation
#1
Christian Brinkmann, Leonie Schäfer, Magd Masoud, Joachim Latsch, Daniel Lay, Wilhelm Bloch, Klara Brixius
Patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing neurodegenerative diseases. There is growing evidence that repeated exercise-induced transient increases in neurotrophic factors can augment neurogenesis and neuroplasticity. This pilot study compares the effects of 30-min submaximal cycling with those of exergaming (combining exercise and video gaming) at the same duration and same rating of perceived exertion (BORG RPE: 14-15) on serum neurotrophic factors in 8 elderly non-insulin-dependent T2DM patients (71±4 years) (2×2 crossover design)...
April 25, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28442034/improving-follow-up-care-for-women-with-a-history-of-gestational-diabetes-perspectives-of-gps-and-patients
#2
Andrew V R Pennington, Sharleen L O'Reilly, Doris Young, James A Dunbar
This paper investigates factors influencing women's engagement with diabetes preventative care after a pregnancy with gestational diabetes (GDM) from the perspectives of GPs and women and explores the role of the GP in that care. Qualitative research using semi-structured interviews with women who had experienced GDM (n=16) and GPs (n=18) were conducted and a thematic content analysis conducted. Women's interviews explored their experience of GDM, factors influencing, and engagement with, follow-up care for diabetes prevention and role of the GP in that care...
April 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28429777/interleukin-6-increases-the-expression-and-activity-of-insulin-degrading-enzyme
#3
Mirian A Kurauti, José M Costa-Júnior, Sandra M Ferreira, Gustavo J Santos, Carlos H G Sponton, Everardo M Carneiro, Guilherme D Telles, Mara P T Chacon-Mikahil, Cláudia R Cavaglieri, Luiz F Rezende, Antonio C Boschero
Impairment of the insulin-degrading enzyme (IDE) is associated with obesity and type 2 diabetes mellitus (T2DM). Here, we used 4-mo-old male C57BL/6 interleukin-6 (IL-6) knockout mice (KO) to investigate the role of this cytokine on IDE expression and activity. IL-6 KO mice displayed lower insulin clearance in the liver and skeletal muscle, compared with wild type (WT), due to reduced IDE expression and activity. We also observed that after 3-h incubation, IL-6, 50 and 100 ng ml(-1), increased the expression of IDE in HEPG2 and C2C12 cells, respectively...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420762/resting-heart-rate-variability-and-exercise-capacity-in-type-1-diabetes
#4
Luke C Wilson, Karen C Peebles, Neil A Hoye, Patrick Manning, Catherine Sheat, Michael J A Williams, Gerard T Wilkins, Genevieve A Wilson, James C Baldi
People with type 1 diabetes (T1D) have lower exercise capacity (V̇O2max) than their age-matched nondiabetic counterparts (CON), which might be related to cardiac autonomic dysfunction. We examined whether Heart Rate Variability (HRV; indicator of cardiac autonomic modulation) was associated with exercise capacity in those with and without T1D. Twenty-three participants with uncomplicated T1D and 17 matched CON were recruited. Heart rate (HR; ECG), blood pressure (BP; finger photo-plethysmography), and respiratory rate (respiratory belt) were measured during baseline, paced-breathing and clinical autonomic reflex tests (CARTs); deep breathing, lying-to-stand, and Valsalva maneuver...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28420673/a-single-bout-of-high-intensity-interval-training-reduces-awareness-of-subsequent-hypoglycemia-in-patients-with-type-1-diabetes
#5
Hanne M Rooijackers, Evita C Wiegers, Marinette van der Graaf, Dick H Thijssen, Roy P C Kessels, Cees J Tack, Bastiaan E de Galan
High-intensity interval training (HIIT) gains increasing popularity in patients with diabetes. HIIT acutely increases plasma lactate levels. This may be important, since administration of lactate during hypoglycemia suppresses symptoms and counterregulation, whilst preserving cognitive function. We tested the hypothesis that HIIT acutely reduces awareness of hypoglycemia and attenuates hypoglycemia-induced cognitive dysfunction. In a randomized crossover trial, patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), patients with impaired awareness of hypoglycemia (IAH), and healthy participants (n=10 per group) underwent a hyperinsulinemic-hypoglycemic (2...
April 18, 2017: Diabetes
https://www.readbyqxmd.com/read/28420250/the-european-association-of-preventive-cardiology-exercise-prescription-in-everyday-practice-and-rehabilitative-training-expert-tool-a-digital-training-and-decision-support-system-for-optimized-exercise-prescription-in-cardiovascular-disease-concept-definitions
#6
Dominique Hansen, Paul Dendale, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Josef Niebauer, Veronique Cornelissen, Roberto Pedretti, Eva Geurts, Gustavo R Ruiz, Ugo Corrà, Jean-Paul Schmid, Eugenio Greco, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona S Braga, Olga Barna, Paul Beckers, Maurizio Bussotti, Robert Fagard, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Daniel Neunhäuserer, Rona Reibis, Martijn A Spruit, Christoph Stettler, Tim Takken, Cajsa Tonoli, Carlo Vigorito, Heinz Völler, Patrick Doherty
Background Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digital training and decision support system for exercise prescription in cardiovascular disease patients in clinical practice: the European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28416496/long-term-cost-reduction-of-routine-medications-following-a-residential-programme-combining-physical-activity-and-nutrition-in-the-treatment-of-type-2-diabetes-a-prospective-cohort-study
#7
Charlotte Lanhers, Guillaume Walther, Robert Chapier, Bruno Lesourd, Geraldine Naughton, Bruno Pereira, Martine Duclos, Agnès Vinet, Philippe Obert, Daniel Courteix, Frédéric Dutheil
OBJECTIVES: To demonstrate that lifestyle modifications will reduce the cost of routine medications in individuals with type 2 diabetes (T2D), through a mechanism involving glycaemic control. DESIGN: A within-trial cost-medication analysis with a 1-year time horizon. SETTING: Controlled environment within the spa resort of Chatel-Guyon, France. PARTICIPANTS: Twenty-nine participants (aged 50-70 years) with T2D. INTERVENTIONS: A 1-year follow-up intervention, beginning with a 3-week residential programme combining high exercise volume (15-20 hours/week), restrictive diet (-500 kcal/day) and education...
April 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28406039/a-methodology-to-compare-insulin-dosing-recommendations-in-real-life-settings
#8
Danielle Groat, Maria A Grando, Bithika Thompson, Pedro Neto, Hiral Soni, Mary E Boyle, Marilyn Bailey, Curtiss B Cook
BACKGROUND: We propose a methodology to analyze complex real-life glucose data in insulin pump users. METHODS: Patients with type 1 diabetes (T1D) on insulin pumps were recruited from an academic endocrinology practice. Glucose data, insulin bolus (IB) amounts, and self-reported alcohol consumption and exercise events were collected for 30 days. Rules were developed to retrospectively compare IB recommendations from the insulin pump bolus calculator (IPBC) against recommendations from a proposed decision aid (PDA) and for assessing the PDA's recommendation for exercise and alcohol...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28401663/does-personality-matter-in-diabetes-adherence-exploring-the-pathways-between-neuroticism-and-patient-adherence-in-couples-with-type-2-diabetes
#9
Joshua R Novak, Jared R Anderson, Matthew D Johnson, Nathan R Hardy, Ann Walker, Allison Wilcox, Virginia L Lewis, David C Robbins
BACKGROUND: Personality has received some attention in the Type 2 diabetes literature; however, research has not linked personality and diabetes adherence behaviors (diet and exercise), identified pathways through which they are associated, nor taken into consideration important contextual factors that influence behavior (the patient's partner). METHODS: Dyadic data from 117 married, heterosexual couples in which one member is diagnosed with Type 2 diabetes was used to explore associations between each partner's neuroticism and patient dietary and exercise adherence through the pathways of negative affect, depression symptoms, and couple-level diabetes efficacy (both patient and spouse report of confidence in the patient's ability to adhere to diabetes management regimens)...
April 12, 2017: Applied Psychology. Health and Well-being
https://www.readbyqxmd.com/read/28400505/no-effect-of-ascorbate-on-cutaneous-vasodilation-and-sweating-in-older-men-and-those-with-type-2-diabetes-exercising-in-the-heat
#10
Naoto Fujii, Robert D Meade, Pegah Akbari, Jeffrey C Louie, Lacy M Alexander, Pierre Boulay, Ronald J Sigal, Glen P Kenny
Aging and chronic disease such as type 2 diabetes (T2D) are associated with impairments in the body's ability to dissipate heat. To reduce the risk of heat-related injuries in these heat vulnerable individuals, it is necessary to identify interventions that can attenuate this impairment. We evaluated the hypothesis that intradermal administration of ascorbate improves cutaneous vasodilation and sweating in older adults via nitric oxide synthase (NOS)-dependent mechanisms during exercise in the heat and whether these improvements, if any, are greater in individuals with T2D...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28398573/skeletal-muscle-pgc1%C3%AE-1-nucleosome-position-and-260nt-dna-methylation-determine-exercise-response-and-prevent-ectopic-lipid-accumulation-in-men
#11
Sudip Bajpeyi, Jeffrey D Covington, Erin M Taylor, Laura K Stewart, Jose E Galgani, Tara M Henagan
Endurance exercise has been shown to improve lipid oxidation and increase mitochondrial content in skeletal muscle: two features that have shown dependence on increased expression of the PPAR gamma co-activator 1 alpha (PGC1α). It is also hypothesized that exercise related alterations in PGC1α expression occur through epigenetic regulation of nucleosome positioning in association with differential DNA methylation status within the PCG1α promoter. Here we show that when primary human myotubes from obese, type 2 diabetics are exposed to lipolytic stimulus (PFI) in vitro, nucleosome occupancy surrounding the -260 nucleotide (nt) region, a known regulatory DNA methylation site, is reduced...
April 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/28397874/proton-pump-inhibitor-use-and-the-risk-of-first-time-ischemic-stroke-in-the-general-population-a-nationwide-population-based-study
#12
Yen-Feng Wang, Yung-Tai Chen, Jiing-Chyuan Luo, Tzeng-Ji Chen, Jaw-Ching Wu, Shuu-Jiun Wang
OBJECTIVES: An increased risk of adverse cardiovascular events was reported for concomitant use of proton-pump inhibitors (PPIs) in patients taking antiplatelet agents. The present study aimed at determining whether PPI use alone could be associated with first-time ischemic stroke. METHODS: This was a retrospective nationwide study using database from Taiwan National Health Insurance and involved subjects aged ≥20 years. In propensity score-matched analysis, patients with current PPI use were compared with propensity score-matched PPI non-use controls at a 1:1 ratio...
April 11, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28394923/effects-and-underlying-mechanisms-of-irisin-on-the-proliferation-and-apoptosis-of-pancreatic-%C3%AE-cells
#13
Shiwei Liu, Fang Du, Xin Li, Mingming Wang, Ruixue Duan, Jiaxin Zhang, Yaru Wu, Qi Zhang
Pancreatic β cell dysfunction and reduction due to glucose toxicity play a crucial role in the development of type 2 diabetes mellitus (T2DM). Irisin, a novel exercise-induced myokine, reduces obesity, improves insulin resistance and lowers blood glucose by promoting the browning of white adipose tissue, thereby enhancing thermogenesis and increasing energy expenditure. Recent studies have reported that irisin promotes cell proliferation and protects cells from apoptosis. However, the effects of irisin on pancreatic β cells are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28394739/exercise-but-not-metformin-improves-health-related-quality-of-life-and-mood-states-in-older-adults-with-type-2-diabetes
#14
Liliana C Baptista, Aristides M Machado-Rodrigues, Raul A Martins
The aim of this cohort study is to analyse the effect of three types of treatment: (i) exercise training with multicomponent exercise (E); (ii) pharmacologic treatment with oral hypoglycaemic drug - metformin (M); and (iii) a combined therapy - exercise and metformin (E + M) on health-related quality of life (HRQoL) and mood states in older adults with type 2 diabetes (T2D) with comorbidity in an early stage of the disease. Participants (n = 284) underwent 1 of the following 3 conditions: (i) E (n = 59) trained three times/week; (ii) M (n = 30) used 850 mg of metformin twice daily; and (iii) E + M (n = 195) combined exercise and metformin...
April 10, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28394194/the-higher-the-insulin-resistance-the-lower-the-cardiac-output-in-men-with-type-1-diabetes-during-the-maximal-exercise-test
#15
Pawel Niedzwiecki, Dariusz Naskret, Stanislaw Pilacinski, Maciej Pempera, Aleksandra Uruska, Anna Adamska, Dorota Zozulinska-Ziolkiewicz
BACKGROUND: The aim of this study was to assess the hemodynamic parameters analyzed in bioimpedance cardiography during maximal exercise in patients with type 1 diabetes differing in insulin resistance. METHODS: The study group consisted of 40 men with type 1 diabetes. Tissue sensitivity to insulin was assessed on the basis of the glucose disposal rate (GDR) analyzed during hyperinsulinemic-euglycemic clamp. Patients were divided into groups with GDR <4.5 mg/kg/min (G1 group-lower insulin sensitivity) and GDR ≥4...
April 10, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28392856/impact-of-physical-activity-in-cardiovascular-and-musculoskeletal-health-can-motion-be-medicine
#16
REVIEW
Gannon L Curtis, Morad Chughtai, Anton Khlopas, Jared M Newman, Rafay Khan, Shervin Shaffiy, Ali Nadhim, Anil Bhave, Michael A Mont
Physical activity is a well-known therapeutic tool for various types of medical conditions, including vasculopathic diseases such as coronary artery disease, stroke, type 2 diabetes, and obesity. Additionally, increased physical activity has been proposed as a therapy to improve musculoskeletal health; however, there are conflicting reports about physical activity potentially leading to degenerative musculoskeletal disease, especially osteoarthritis (OA). Additionally, although physical activity is known to have its benefits, it is unclear as to what amount of physical activity is the most advantageous...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28392340/exercise-intensity-redox-homeostasis-and-inflammation-in-type-2-diabetes-mellitus
#17
Alistair R Mallard, Siri Marte Hollekim-Strand, Jeff S Coombes, Charlotte B Ingul
OBJECTIVES: To compare 12 weeks of exercise training at two intensities on oxidative stress, antioxidants and inflammatory biomarkers in patients with type 2 diabetes (T2D). DESIGN: Randomized trial. METHODS: Thirty-six participants with T2D were randomized to complete either 12 weeks of treadmill based high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT), followed by 40 weeks of home-based training at the same intensities...
March 21, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28389489/long-term-effect-of-smartphone-delivered-interval-walking-training-on-physical-activity-in-patients-with-type-2-diabetes-protocol-for-a-parallel-group-single-blinded-randomised-controlled-trial
#18
Laura Staun Valentiner, Mathias Ried-Larsen, Kristian Karstoft, Cecilie Fau Brinkløv, Charlotte Brøns, Rasmus Oestergaard Nielsen, Robin Christensen, Jens Steen Nielsen, Allan Arthur Vaag, Bente Klarlund Pedersen, Henning Langberg
INTRODUCTION: Physical activity is a cornerstone in type 2 diabetes (T2D) rehabilitation. Effective long-term and low-cost strategies to keep these patients' physically active are needed. However, maintaining physical activity behaviour is difficult once formalised interventions end. Structured exercise training supported by mobile technology and remote feedback is potentially an effective strategy. The objective of the trial is to investigate whether mobile health support using the InterWalk application for smartphones is effective in increasing physical activity levels in persons with T2D over time compared with standard care...
April 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28386795/-metabolic-and-cardiovascular-response-to-exercise-in-patients-with-type-1-diabetes
#19
I Turinese, P Marinelli, M Bonini, M Rossetti, G Statuto, T Filardi, A Paris, A Lenzi, S Morano, P Palange
PURPOSE: Physical activity is an effective therapeutic tool for cardiovascular risk prevention. However, exercise aerobic capacity of patients with type 1 diabetes (T1DM) has not been thoroughly investigated. Aim of the present study is to evaluate exercise aerobic capacity in patients with T1DM compared to a normal control population. METHODS: This observational study included 17 T1DM patients and 17 matched healthy volunteers. Cardiopulmonary exercise test (CPET) was conducted on an electronically-braked cycle ergometer...
April 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28378202/exercise-training-but-not-curcumin-supplementation-decreases-immune-cell-infiltration-in-the-pancreatic-islets-of-a-genetically-susceptible-model-of-type-1-diabetes
#20
Leandro Kansuke Oharomari, Camila de Moraes, Anderson Marliere Navarro
BACKGROUND: The main mechanism involved in the pathogenesis of autoimmunity is an uncontrolled inflammatory response against self-antigens. Therefore, anti-inflammatory factors, such as the intake of bioactive compounds and a physically active lifestyle, may decrease or cease the development of autoimmune diseases. Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic β cell destruction. The non-obese diabetic (NOD) mouse is a model of spontaneous T1D and is the model most similar to human disease...
December 2017: Sports Medicine—Open
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