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Exercise, type-1 diabetes

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https://www.readbyqxmd.com/read/28324962/design-of-a-dual-hormone-model-predictive-control-for-artificial-pancreas-with-exercise-model
#1
Navid Resalat, Joseph El Youssef, Ravi Reddy, Peter G Jacobs
The Artificial Pancreas (AP) is a new technology for helping people with type 1 diabetes to better control their glucose levels through automated delivery of insulin and optionally glucagon in response to sensed glucose levels. In a dual hormone AP, insulin and glucagon are delivered automatically to the body based on glucose sensor measurements using a control algorithm that calculates the amount of hormones to be infused. A dual-hormone MPC may deliver insulin continuously; however, it must avoid continuous delivery of glucagon because nausea can occur from too much glucagon...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28319109/the-broad-study-a-randomised-controlled-trial-using-a-whole-food-plant-based-diet-in-the-community-for-obesity-ischaemic-heart-disease-or-diabetes
#2
N Wright, L Wilson, M Smith, B Duncan, P McHugh
BACKGROUND/OBJECTIVE: There is little randomised evidence using a whole food plant-based (WFPB) diet as intervention for elevated body mass index (BMI) or dyslipidaemia. We investigated the effectiveness of a community-based dietary programme. Primary end points: BMI and cholesterol at 6 months (subsequently extended). SUBJECTS: Ages 35-70, from one general practice in Gisborne, New Zealand. Diagnosed with obesity or overweight and at least one of type 2 diabetes, ischaemic heart disease, hypertension or hypercholesterolaemia...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28318938/diabetes-nurse-case-management-in-a-canadian-tertiary-care-setting-results-of-a-randomized-controlled-trial
#3
Danni Li, Tom Elliott, Gerri Klein, Ehud Ur, Tricia S Tang
OBJECTIVES: To examine the effects of a 6-month nurse case manager (NCM) intervention compared to standard care (SC) on glycemic control and diabetes distress in a Canadian tertiary-care setting. METHODS: We recruited 140 adults with type 2 diabetes and glycated hemoglobin (A1C) levels >8% (64 mmol/mol) from 2 tertiary care facilities and randomized them to: 1) a 6-month NCM intervention in addition to SC or 2) SC by the primary endocrinologists. Assessments were conducted at baseline and at 6 months...
March 17, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28296226/diabetic-polyneuropathy-is-a-risk-factor-for-decline-of-lower-extremity-strength-in-patients-with-type-2-diabetes
#4
Takuo Nomura, Tomoyasu Ishiguro, Masayoshi Ohira, Yukio Ikeda
AIMS/INTRODUCTION: The present study elucidated the effect of diabetic polyneuropathy (DPN) on lower extremity strength in a wide age range of type 2 diabetic patients. MATERIALS AND METHODS: Participants (n = 1,442) were divided into three age groups (30-49 years, 50-69 years, and 70-87 years), and comparisons were made separately for each sex. Lower extremity strength was measured in terms of knee extension force (KEF) with a hand-held dynamometer. KEF was compared according to the presence or absence of DPN...
March 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28292741/writing-for-health-rationale-and-protocol-for-a-randomized-controlled-trial-of-internet-based-benefit-finding-writing-for-adults-with-type-1-or-type-2-diabetes
#5
Joanna Crawford, Kay Wilhelm, Lisa Robins, Judy Proudfoot
BACKGROUND: Diabetes mellitus is Australia's fastest growing chronic disease, and has high comorbidity with depression. Both subthreshold depression and diabetes distress are common amongst people with type 1 or type 2 diabetes, and are associated with poorer diabetes self-care. A need exists for low-intensity self-help interventions for large numbers of people with diabetes and diabetes distress or subthreshold depression, as part of a stepped-care approach to meeting the psychological needs of people with diabetes...
March 14, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28292300/clinical-outcomes-and-glycaemic-responses-to-different-aerobic-exercise-training-intensities-in-type-ii-diabetes-a-systematic-review-and-meta-analysis
#6
Aimee Grace, Erick Chan, Francesco Giallauria, Petra L Graham, Neil A Smart
AIMS: To establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes. METHODS: A systematic search was conducted to identify studies through a search of MEDLINE (1985 to Sept 1, 2016, Cochrane Controlled Trials Registry (1966 to Sept 1, 2016), CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of MeSH and free text terms for related key concepts...
March 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28291838/level-and-correlates-of-physical-activity-and-sedentary-behavior-in-patients-with-type-2-diabetes-a-cross-sectional-analysis-of-the-italian-diabetes-and-exercise-study_2
#7
Stefano Balducci, Valeria D'Errico, Jonida Haxhi, Massimo Sacchetti, Giorgio Orlando, Patrizia Cardelli, Nicolina Di Biase, Lucilla Bollanti, Francesco Conti, Silvano Zanuso, Antonio Nicolucci, Giuseppe Pugliese
OBJECTIVE: Patients with type 2 diabetes usually show reduced physical activity (PA) and increased sedentary (SED)-time, though to a varying extent, especially for low-intensity PA (LPA), a major determinant of daily energy expenditure that is not accurately captured by questionnaires. This study assessed the level and correlates of PA and SED-time in patients from the Italian Diabetes and Exercise Study_2 (IDES_2). METHODS: Three-hundred physically inactive and sedentary patients with type 2 diabetes were enrolled in the IDES_2 to be randomized to an intervention group, receiving theoretical and practical exercise counseling, and a control group, receiving standard care...
2017: PloS One
https://www.readbyqxmd.com/read/28289908/why-should-people-with-type-1-diabetes-exercise-regularly
#8
Roberto Codella, Ileana Terruzzi, Livio Luzi
Plethoric evidence reminds of the protective effects of exercise against a number of health risks, across all ages, in the general population. The benefits of exercise for individuals with type 2 diabetes are indisputable. An in-depth understanding of energy metabolism has reasonably entailed exercise as a cornerstone in the lifestyle of almost all subjects with type 1 diabetes. Nevertheless, individuals with type 1 diabetes often fail in accomplishing exercise guidelines and they are less active than their peer without diabetes...
March 14, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28280005/kcne2-deletion-impairs-insulin-secretion-and-causes-type-2-diabetes-mellitus
#9
Soo Min Lee, Jasmine Baik, Dara Nguyen, Victoria Nguyen, Shiwei Liu, Zhaoyang Hu, Geoffrey W Abbott
Type 2 diabetes mellitus (T2DM) represents a rapidly increasing threat to global public health. T2DM arises largely from obesity, poor diet, and lack of exercise, but it also involves genetic predisposition. Here we report that the KCNE2 potassium channel transmembrane regulatory subunit is expressed in human and mouse pancreatic β cells. Kcne2 deletion in mice impaired glucose tolerance as early as 5 wk of age in pups fed a Western diet, ultimately causing diabetes. In adult mice fed normal chow, skeletal muscle expression of insulin receptor β and insulin receptor substrate 1 were down-regulated 2-fold by Kcne2 deletion, characteristic of T2DM...
March 9, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28272368/use-of-wearable-sensors-and-biometric-variables-in-an-artificial-pancreas-system
#10
Kamuran Turksoy, Colleen Monforti, Minsun Park, Garett Griffith, Laurie Quinn, Ali Cinar
An artificial pancreas (AP) computes the optimal insulin dose to be infused through an insulin pump in people with Type 1 Diabetes (T1D) based on information received from a continuous glucose monitoring (CGM) sensor. It has been recognized that exercise is a major challenge in the development of an AP system. The use of biometric physiological variables in an AP system may be beneficial for prevention of exercise-induced challenges and better glucose regulation. The goal of the present study is to find a correlation between biometric variables such as heart rate (HR), heat flux (HF), skin temperature (ST), near-body temperature (NBT), galvanic skin response (GSR), and energy expenditure (EE), 2D acceleration-mean of absolute difference (MAD) and changes in glucose concentrations during exercise via partial least squares (PLS) regression and variable importance in projection (VIP) in order to determine which variables would be most useful to include in a future artificial pancreas...
March 7, 2017: Sensors
https://www.readbyqxmd.com/read/28271805/endocrinology-and-pediatric-exercise-science-2016
#11
Alon Eliakim
The Pediatric Exercise Science Year That Was section aims to highlight the most important (to the author's opinion) manuscripts that were published in 2016 in the field of endocrinology and pediatric exercise science. This year's selection includes studies showing that 1) Induction of T4 to T3 conversion by type 2 deiodinase following aerobic exercise in skeletal muscles was associated with concomitant increase in peroxisome proliferatoractivated receptor-γ coactivator-1α, and mitochondrial oxidative capacity and therefore plays an important mechanistic role in the muscle adaptation to exercise training...
February 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28270522/high-intensity-exercise-as-a-dishabituating-stimulus-restores-counterregulatory-responses-in-recurrently-hypoglycemic-rodents
#12
Alison D McNeilly, Jennifer R Gallagher, Jeffrey T-J Huang, Michael L J Ashford, Rory J McCrimmon
Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to hypoglycemia explain the frequency of hypoglycemia occurrence in T1D. Defective counterregulation results to a large extent from prior exposure to hypoglycemia per se, leading to a condition called impaired awareness of hypoglycemia (IAH); the cause of which is unknown. In the present study, we investigate the hypothesis that IAH develops through a special type of adaptive memory referred to as habituation...
March 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28267267/peripheral-neuropathy-in-prediabetes-and-the-metabolic-syndrome
#13
REVIEW
Amro M Stino, A Gordon Smith
Peripheral neuropathy is a major cause of disability worldwide. Diabetes is the most common cause of neuropathy, accounting for 50% of cases. Over half of people with diabetes develop neuropathy, and diabetic neuropathy (DPN) is a major cause of reduced quality of life due to pain, sensory loss, gait instability, fall related injury, and foot ulceration and amputation. Most patients with nondiabetic neuropathy have cryptogenic sensory peripheral neuropathy (CSPN). A growing body of literature links prediabetes, obesity and metabolic syndrome (MetS) to risk of both DPN and CSPN (CSPN-MetS)...
March 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28265345/exercise-induced-albuminuria-vs-circadian-variations-in-blood-pressure-in-type-1-diabetes
#14
Isabelle Hota Tadida Meli, Aurel T Tankeu, Mesmin Y Dehayem, David Chelo, Jean Jacques N Noubiap, Eugene Sobngwi
AIM: To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents. METHODS: We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28265302/increased-risk-of-metabolic-disorders-in-healthy-young-adults-with-family-history-of-diabetes-from-the-korea-national-health-and-nutrition-survey
#15
Joon Ho Moon, Eun Roh, Tae Jung Oh, Kyoung Min Kim, Jae Hoon Moon, Soo Lim, Hak Chul Jang, Sung Hee Choi
BACKGROUND: We assessed the impact of a family history of diabetes on type 2 diabetes, metabolic syndrome, and behavioral traits in young Korean adults. METHODS: Subjects aged 25-44 years were included, and the presence of a family history of diabetes was obtained by a self-reported questionnaire (the Korea National Health and Nutrition Survey 2010). We compared the prevalence of type 2 diabetes and metabolic syndrome, and other metabolic parameters, including blood pressure and lipid profile...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28263745/exercise-increases-hyper-acetylation-of-histones-on-the-cis-element-of-nrf-1-binding-to-the-mef2a-promoter-implications-on-type-2-diabetes
#16
Jitcy S Joseph, Ademola O Ayeleso, Emmanuel Mukwevho
Exercise brings changes on the chromatin ensuing the upregulation of many genes that confer protection from type 2 diabetes. In type-2 diabetes, critical genes are down-regulated such as those involved in glucose transport (GLUT4, MEF2A) and also oxidative phosphorylation (NRF-1 and its target genes). Recent reports have shown that NRF-1 not only regulate mitochondrial oxidative genes but also controls MEF2A, the main transcription factor for glucose transporter, GLUT4. Such dual control of the two pathways by NRF-1 place it as critical gene in the design of therapeutic modalities much needed to cure or better manage type 2 diabetes...
March 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28255965/high-intensity-exercise-in-men-with-type-1-diabetes-and-mode-of-insulin-therapy
#17
Andrzej Gawrecki, Dariusz Naskret, Pawel Niedzwiecki, Anna Duda-Sobczak, Aleksandra Araszkiewicz, Dorota Zozulinska-Ziolkiewicz
The purpose of this study was to evaluate the impact of high intensity exercise on glucose levels and risk of metabolic decompensation in males with type 1 diabetes (T1D), depending on the method of insulin administration. The study comprised 29 males (aged 25.3±5.1 years; duration of diabetes 10.3±3.2 years) treated with continuous subcutaneous insulin infusion (CSII) or multiple daily insulin injections (MDI). Treadmill exercise test was performed twice in each patient until subjective exhaustion as maximum according to the Borg scale...
March 2, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28255731/acute-effects-of-post-absorptive-and-postprandial-moderate-exercise-on-markers-of-inflammation-in-hyperglycemic-individuals
#18
Håvard Nygaard, Gunnar Slettaløkken Falch, Jon Elling Whist, Ivana Hollan, Stian Ellefsen, Gerd Holmboe-Ottesen, Bent R Rønnestad, Arne T Høstmark
PURPOSE: Systemic inflammation is involved in the development of several diseases, including cardiovascular disease and type 2 diabetes. It is known that vigorous exercise affects systemic inflammation, but less is known about exercise at lower intensities. Hyperglycemia can also entail pro-inflammatory responses; however, postprandial hyperglycemia is blunted if the meal is followed by exercise. Hypotheses were: (1) moderate physical exercise acutely affects levels of C-reactive protein (CRP) and serum soluble vascular cell adhesion molecule 1 (sVCAM-1) in hyperglycemic individuals and (2) the effect depends on whether the activity is performed in a post-absorptive or postprandial state...
March 2, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28251726/outcomes-of-algorithm-based-modifications-of-insulinotherapy-during-exercise-in-mdi-vs-insulin-pump-treated-children-with-type-1-diabetes-results-from-the-tread-diab-study
#19
S Moniotte, M Owen, T Barrea, A Robert, P A Lysy
OBJECTIVES: To evaluate the evolution of subcutaneous glucose (SG) after a standardized aerobic exercise in children and adolescents treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injection (MDI) regimen before and after adaptation of insulin doses. RESEARCH DESIGN AND METHODS: Eleven CSII- and 13 MDI-treated patients performed 2 30-minute sessions of moderate to vigorous (70% of age-based maximal heart rate) exercise on a treadmill under continuous glucose monitoring (CGM)...
March 2, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28245784/closing-the-loop-on-exercise-in-type-1-diabetes
#20
Lia Bally, Hood Thabit
BACKGROUND: Despite its well-established health benefits, exercise imposes challenges on glucose control in individuals with type 1 diabetes due to to the complex interactions between exercise-induced effects on glucose metabolism and exogenous insulin therapy. Although clinical guidelines for exercise management in type 1 diabetes are available, implementation is challenging in daily -life. The risk of exercise-induced dysglycaemia deters many people with type 1 diabetes from participating and benefiting from exercise...
February 28, 2017: Current Diabetes Reviews
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