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Exercise, type-1 diabetes

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https://www.readbyqxmd.com/read/27906837/different-impacts-of-hypertension-and-diabetes-mellitus-on-all-cause-and-cardiovascular-mortality-in-community-dwelling-older-adults-the-rancho-bernardo-study
#1
Jee-Young Oh, Matthew A Allison, Elizabeth Barrett-Connor
OBJECTIVES: Although the prevalence rates of hypertension (HTN) and diabetes mellitus are slowing in some high-income countries, HTN and diabetes mellitus remain as the two major risk factors for atherosclerotic cardiovascular disease (CVD), the leading cause of death in the United States and worldwide. We aimed to observe the association of HTN and diabetes mellitus with all-cause and CVD mortality in older white adults. METHODS: All community-dwelling Rancho Bernardo Study participants who were at least 55 years old and had carefully measured blood pressure and plasma glucose from 75-g oral glucose tolerance test at the baseline visit (1984-1987, n = 2186) were followed up until death or the last clinic visit in 2013 (median 14...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27904925/breaking-sitting-with-light-activities-vs-structured-exercise-a-randomised-crossover-study-demonstrating-benefits-for-glycaemic-control-and-insulin-sensitivity-in-type-2-diabetes
#2
Bernard M F M Duvivier, Nicolaas C Schaper, Matthijs K C Hesselink, Linh van Kan, Nathalie Stienen, Bjorn Winkens, Annemarie Koster, Hans H C M Savelberg
AIMS/HYPOTHESIS: We aimed to examine the effects of breaking sitting with standing and light-intensity walking vs an energy-matched bout of structured exercise on 24 h glucose levels and insulin resistance in patients with type 2 diabetes. METHODS: In a randomised crossover study, 19 patients with type 2 diabetes (13 men/6 women, 63 ± 9 years old) who were not using insulin each followed three regimens under free-living conditions, each lasting 4 days: (1) Sitting: 4415 steps/day with 14 h sitting/day; (2) Exercise: 4823 steps/day with 1...
December 1, 2016: Diabetologia
https://www.readbyqxmd.com/read/27893563/resistance-training-improves-muscle-function-and-cardiometabolic-risks-but-not-quality-of-life-in-older-people-with-type-2-diabetes-mellitus-a-randomized-controlled-trial
#3
Ping-Lun Hsieh, Chin-Hsiao Tseng, Yufeng Jane Tseng, Wei-Shiung Yang
BACKGROUND AND PURPOSE: In older people with type 2 diabetes mellitus (T2DM), the effects of aging and T2DM may compromise the function of skeletal muscle, deteriorate metabolic status, and jeopardize physical performance, aerobic capacity, and quality of life (QoL). The purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on muscle function, physical performance, cardiometabolic risks, and QoL in older people with T2DM. METHODS: This study was a randomized controlled trial that employed block randomization, assessor blinding, and the intention-to-treat principle...
November 23, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27884660/exenatide-improves-diastolic-function-and-attenuates-arterial-stiffness-but-does-not-alter-exercise-capacity-in-individuals-with-type-2-diabetes
#4
Rebecca L Scalzo, Kerrie L Moreau, Cemal Ozemek, Leah Herlache, Shawna McMillin, Sarah Gilligan, Amy G Huebschmann, Tim A Bauer, Jennifer Dorosz, Jane E B Reusch, Judith G Regensteiner
BACKGROUND: Exercise is recommended as a cornerstone of treatment for type 2 diabetes mellitus (T2DM), however, it is often poorly adopted by patients. Even in the absence of apparent cardiovascular disease, persons with T2DM have an impaired ability to carry out maximal and submaximal exercise and these impairments are correlated with cardiac and endothelial dysfunction. Glucagon-like pepetide-1 (GLP-1) augments endothelial and cardiac function in T2DM. We hypothesized that administration of a GLP-1 agonist (exenatide) would improve exercise capacity in T2DM...
October 7, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27881389/changes-in-skeletal-muscle-and-organ-size-after-a-weight-loss-intervention-in-overweight-and-obese-type-2-diabetic-patients
#5
Dympna Gallagher, David E Kelley, John Thornton, Lawrence Boxt, Xavier Pi-Sunyer, Edward Lipkin, Ebenezer Nyenwe, Isaiah Janumala, Stanley Heshka
BACKGROUND: The effect of a weight-loss intervention on the masses of lean tissues and organs in humans is not well known. OBJECTIVE: We studied the effects of a diet and exercise weight-loss intervention on skeletal muscle (SM) mass and selected organs over 2 y using MRI in overweight adults with type 2 diabetes. DESIGN: Participants were 53 women and 39 men [mean ± SD: age 58 ± 7 y; body mass index (BMI; in kg/m(2)) 32 ± 3] enrolled in the Look AHEAD (Action for Health in Diabetes) trial and randomly assigned to an intensive lifestyle intervention (ILI) or diabetes support and education (DSE) on whom 2 y of data were collected...
November 23, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27876096/a-randomised-controlled-trial-of-the-effects-of-very-low-carbohydrate-and-high-carbohydrate-diets-on-cognitive-performance-in-patients-with-type-2-diabetes
#6
Jeannie Tay, Ian T Zajac, Campbell H Thompson, Natalie D Luscombe-Marsh, Vanessa Danthiir, Manny Noakes, Jonathan D Buckley, Gary A Wittert, Grant D Brinkworth
This study compared the longer-term effects of a very low-carbohydrate, high-fat diet with a high-carbohydrate, low-fat diet on cognitive performance in individuals with type 2 diabetes (T2D). In total, 115 obese adults with T2D (sixty-six males, BMI: 34·6 (sd 4·3) kg/m2, age: 58 (sd 7) years, HbA1c: 7·3 (sd 1·1) %, diabetes duration: 8 (sd 6) years) were randomised to consume either an energy-restricted, very low-carbohydrate, low-saturated-fat (LC) diet or an energy-matched high unrefined carbohydrate, low-fat (HC) diet with supervised aerobic/resistance exercise (60 min, 3 d/week) for 52 weeks...
November 23, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27871063/dioscorea-esculenta-induced-increase-in-muscle-sex-steroid-hormones-is-associated-with-enhanced-insulin-sensitivity-in-a-type-2-diabetes-rat-model
#7
Koji Sato, Satoshi Fujita, Motoyuki Iemitsu
The effects of chronic Dioscorea esculenta administration and exercise training on muscle sex steroid hormone levels and insulin resistance in type 2 diabetes rats was assessed. Twenty-wk-old male Otsuka Long Evans Tokushima Fatty (OLETF) rats were assigned randomly to the control, D. esculenta treatment, D. esculenta with 5α-reductase inhibitor treatment, or the exercise training groups (running at 25 m/min for 1 h, 5 d/wk; n = 10 each group). Eight weeks of D. esculenta treatment or exercise training significantly attenuated the increase in plasma insulin and fasting glucose levels...
November 8, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27866759/adherence-to-healthy-lifestyle-factors-and-risk-of-death-in-men-with-diabetes-mellitus-the-physicians-health-study
#8
Yash R Patel, Taraka V Gadiraju, J Michael Gaziano, Luc Djoussé
BACKGROUND & AIMS: The relationship between healthy lifestyle factors and mortality in people with type 2 diabetes is unclear. The purpose of this study was to examine whether healthy lifestyle factors are associated with mortality in people with type 2 diabetes. METHODS: We prospectively studied 1163 men with type 2 diabetes from the Physicians' Health Study. Lifestyle factors consisted of currently not smoking, moderate drinking (1-2 drinks/day), vigorous exercise (1+/week), BMI < 25 kg/m(2), and being in the top 2 quintiles of the alternate healthy eating index-2010 (AHEI-2010)...
November 11, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27860496/predicting-insulin-treatment-scenarios-with-the-net-effect-method-domain-of-validity
#9
Martina Vettoretti, Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli
BACKGROUND: A simulation methodology based on the net effect, a signal estimated from continuous glucose monitoring (CGM) and insulin data accounting for sources of glucose variability, for example, meals and exercise, has been proposed. This method has been recently used to "replay" real-life treatment scenarios and determine the minimal level of CGM sensor accuracy required for nonadjunctive use. Given the potential of the net effect method, it is important to assess its domain of validity...
November 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27855341/the-relationship-of-fasting-hyperglycemia-to-changes-in-fat-and-muscle-mass-after-exercise-training-in-type-2-diabetes
#10
Swaytha V Yalamanchi, Kerry J Stewart, Nan Ji, Sherita H Golden, Adrian Dobs, Diane M Becker, Dhananjay Vaidya, Brian G Kral, Rita R Kalyani
AIMS: Exercise training (ET) has been variably associated with body composition changes among persons with type 2 diabetes (T2DM). The degree to which these changes are related to hyperglycemia remains unclear. Our objective was to investigate the relationship of baseline fasting glucose (FG) to the magnitude of muscle gains and fat loss after ET in individuals with T2DM. METHODS: Participants were enrolled in the SHAPE-2 trial, a six month supervised aerobic and resistance training intervention (three days/week), at Johns Hopkins...
October 10, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27846876/in-vitro-alpha-amylase-inhibitory-activity-of-the-leaf-extracts-of-adenanthera-pavonina
#11
M Nirmali Wickramaratne, J C Punchihewa, D B M Wickramaratne
BACKGROUND: Diabetes has caused a major burden to the health sector in the developing countries and has shown an increasing trend among the urban population. It is estimated that most patients are with type II diabetes which could be easily treated with dietary changes, exercise, and medication. Sri Lanka carries a long history ayurvedic medicine where it uses the plant for treating many diseases. Therefore it is important to screen medicinal plants scientifically so they could be used safely and effectively in the traditional medical system and also be used for further investigations...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27832652/regulation-of-gene-expression-by-exercise-related-micrornas
#12
Laureane Nunes Masi, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Leonardo Dos Reis Silveira, Maria Fernanda Cury-Boaventura, Tania Cristina Pithon-Curi, Rui Curi, Renata Gorjão, Sandro Massao Hirabara
Gene expression control by microRNAs (miRs) is an important mechanism for maintenance of cellular homeostasis in physiological and pathological conditions as well as in response to different stimuli including nutritional factors and exercise. MiRs are involved in regulation of several processes such as growth and development, fuel metabolism, insulin secretion, immune function, miocardium remodeling, cell proliferation, differenciation, survival, and death. These molecules have also been proposed to be potential biomarkers and/or therapeutical targets in obesity, type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, and cancer...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27819153/faster-heart-rate-and-muscular-oxygen-uptake-kinetics-in-type-2-diabetes-patients-following-endurance-training
#13
Jessica Koschate, Uwe Drescher, Christian Brinkmann, Klaus Baum, Thorsten Schiffer, Joachim Latsch, Klara Brixius, Uwe Hoffmann
Cardiorespiratory kinetics were analyzed in type 2 diabetes patients before and after a 12-week endurance exercise-training intervention. It was hypothesized that muscular oxygen uptake and heart rate (HR) kinetics would be faster after the training intervention and that this would be detectable using a standardized work rate protocol with pseudo-random binary sequences. The cardiorespiratory kinetics of 13 male sedentary, middle-aged, overweight type 2 diabetes patients (age, 60 ± 8 years; body mass index, 33 ± 4 kg·m(-2)) were tested before and after the 12-week exercise intervention...
November 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27810975/association-between-obesity-indices-and-type-2-diabetes-mellitus-among-middle-aged-and-elderly-people-in-jinan-china-a-cross-sectional-study
#14
Shukang Wang, Wei Ma, Zhongshang Yuan, Shu-Mei Wang, Xiangren Yi, Hongying Jia, Fuzhong Xue
BACKGROUND: The relationship between obesity and type 2 diabetes mellitus (T2DM) varies with geographical area and race. OBJECTIVES: To investigate the prevalence of T2DM and the proportion of subjects with undiagnosed T2DM. In addition, to compare the associations between different obesity indices and T2DM for middle-aged and elderly people from six communities in Jinan, China. SETTING: A cross-sectional study was designed and the study subjects were chosen from blocks which were randomly selected in the 6 communities of Jinan, China in 2011-2012...
November 3, 2016: BMJ Open
https://www.readbyqxmd.com/read/27798656/third-exposure-to-a-reduced-carbohydrate-meal-lowers-evening-postprandial-insulin-and-gip-responses-and-homa-ir-estimate-of-insulin-resistance
#15
Po-Ju Lin, Katarina T Borer
BACKGROUND: Postprandial hyperinsulinemia, hyperglycemia, and insulin resistance increase the risk of type 2 diabetes (T2D) and cardiovascular disease mortality. Postprandial hyperinsulinemia and hyperglycemia also occur in metabolically healthy subjects consuming high-carbohydrate diets particularly after evening meals and when carbohydrate loads follow acute exercise. We hypothesized the involvement of dietary carbohydrate load, especially when timed after exercise, and mediation by the glucose-dependent insulinotropic peptide (GIP) in this phenomenon, as this incretin promotes insulin secretion after carbohydrate intake in insulin-sensitive, but not in insulin-resistant states...
2016: PloS One
https://www.readbyqxmd.com/read/27795984/pulmonary-predictors-of-incident-diabetes-in-smokers
#16
Gregory L Kinney, Emma H Baker, Oana L Klein, Jennifer L Black-Shinn, Emily S Wan, Barry Make, Elizabeth Regan, Russell P Bowler, Sharon M Lutz, Kendra A Young, Lindsey M Duca, George R Washko, Edwin K Silverman, James D Crapo, John E Hokanson
BACKGROUND: Diabetes mellitus and its complications are a large and increasing burden for health care worldwide. Reduced pulmonary function has been observed in diabetes (both type 1 and type 2), and this reduction is thought to occur prior to diagnosis. Other measures of pulmonary health are associated with diabetes, including lower exercise tolerance, greater dyspnea, lower quality of life (as measured by the St. George's Respiratory Questionaire [SGRQ]) and susceptibility to lung infection and these measures may also predate diabetes diagnosis...
2016: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://www.readbyqxmd.com/read/27793836/educating-professionals-to-support-self-management-in-people-with-asthma-or-diabetes-protocol-for-a-systematic-review-and-scoping-exercise
#17
Nicola McCleary, Amanda Andrews, Susan Morrow, Sharon Wiener-Ogilvie, Monica Fletcher, Liz Steed, Stephanie J C Taylor, Hilary Pinnock
INTRODUCTION: Supported self-management for asthma helps people adjust their treatment in response to symptom changes. This improves day-to-day control and reduces the risk of asthma attacks and the need for emergency healthcare. However, implementation remains poor in routine clinical practice. This systematic review is part of a programme of work developing an intervention to help primary care practice teams embed self-management support into routine asthma care. The aim of the review is to synthesise the evidence regarding the effectiveness of educational interventions for professionals supporting self-management in people with asthma or diabetes (type 1 and type 2)...
October 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/27792174/-a-vegetarian-vs-conventional-hypocaloric-diet-the-effect-on-physical-fitness-in-response-to-aerobic-exercise-in-patients-with-type-2-diabetes-a-parallel-randomized-study
#18
Jiri Veleba, Martin Matoulek, Martin Hill, Terezie Pelikanova, Hana Kahleova
It has been shown that it is possible to modify macronutrient oxidation, physical fitness and resting energy expenditure (REE) by changes in diet composition. Furthermore, mitochondrial oxidation can be significantly increased by a diet with a low glycemic index. The purpose of our trial was to compare the effects of a vegetarian (V) and conventional diet (C) with the same caloric restriction (-500 kcal/day) on physical fitness and REE after 12 weeks of diet plus aerobic exercise in 74 patients with type 2 diabetes (T2D)...
October 26, 2016: Nutrients
https://www.readbyqxmd.com/read/27776846/-prevention-of-preterm-birth-complications-by-antenatal-corticosteroid-administration
#19
T Schmitz
OBJECTIVE: To evaluate short- and long-term benefits and risks associated with antenatal administration of a single course of corticosteroids and the related strategies: multiple and rescue courses. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: Antenatal administration of a single course of corticosteroids before 34 weeks of gestation is associated in the neonatal period with a significant reduction of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and death (LE1), and in possibly childhood with a reduction of cerebral palsy and increased psychomotor development index and intact survival (LE3)...
October 21, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27773709/effects-of-aerobic-resistance-and-combined-exercise-training-on-insulin-resistance-markers-in-overweight-or-obese-children-and-adolescents-a-systematic-review-and-meta-analysis
#20
REVIEW
Elisa Corrêa Marson, Rodrigo Sudatti Delevatti, Alexandre Konig Garcia Prado, Nathalie Netto, Luiz Fernando Martins Kruel
OBJECTIVE: To assess the associations of aerobic, resistance, and combined exercise with changes in insulin resistance, fasting glucose, and fasting insulin in children and adolescents who are overweight or obese. DATA SEARCHES: MEDLINE via Pubmed, Cochrane-CENTRAL, SPORTDiscus, and LILACS. STUDY SELECTION: Randomized clinical trials of at least six weeks of duration that evaluated the ability of exercise training to lower at least one of the following outcomes: insulin resistance-HOMA, fasting glucose, and fasting insulin in children and/or adolescents classified as obese or overweight...
December 2016: Preventive Medicine
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