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https://www.readbyqxmd.com/read/28217268/anti-musk-positive-myasthenia-gravis-and-three-semiological-cardinal-signs
#1
André P C Matta, Ana C Andorinho F Ferreira, Arielle Kirmse, Anna Carolina Damm, João Gabriel D I B Farinhas, Mariane D Barbosa, Mayara C M Teles, Camila Fiorelli, Rossano Fiorelli, Osvaldo J M Nascimento, Marco Orsini
Myasthenia gravis (MG) is a relatively uncommon disorder with an annual incidence of approximately 7 to 9 new cases per million. The prevalence is about 70 to 165 per million. The prevalence of the disease has been increasing over the past five decades. This is thought to be due to better recognition of the condition, aging of the population, and the longer life span of affected patients. MG causes weakness, predominantly in bulbar, facial, and extra-ocular muscles, often fluctuating over minutes to weeks, in the absence of wasting, sensory loss, or reflex changes...
November 2, 2016: Neurology International
https://www.readbyqxmd.com/read/28196068/comparison-of-outcomes-following-a-cytological-or-histological-diagnosis-of-malignant-mesothelioma
#2
Sanjeevan Muruganandan, Helman Alfonso, Peter Franklin, Keith Shilkin, Amanda Segal, Nola Olsen, Alison Reid, Nick de Klerk, Aw Bill Musk, Fraser Brims
BACKGROUND: Survival with the epithelioid subtype of malignant mesothelioma (MM) is longer than the biphasic or sarcomatoid subtypes. There is concern that cytology-diagnosed epithelioid MM may underdiagnose the biphasic subtype. This study examines survival differences between patients with epithelioid MM diagnosed by cytology only and other subtypes diagnosed by histology. METHODS: Demographics, diagnosis method, MM subtype and survival were extracted from the Western Australia (WA) Mesothelioma Registry, which records details of all MM cases occurring in WA...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28186707/mesenchymal-stromal-cell-therapy-for-chronic-lung-allograft-dysfunction-results-of-a-first-in-man-study
#3
Daniel C Chambers, Debra Enever, Sharon Lawrence, Marian J Sturm, Richard Herrmann, Stephanie Yerkovich, Michael Musk, Peter M A Hopkins
Chronic lung transplant rejection (termed chronic lung allograft dysfunction [CLAD]) is the main impediment to long-term survival after lung transplantation. Bone marrow-derived mesenchymal stromal cells (MSCs) represent an attractive cell therapy in inflammatory diseases, including organ rejection, given their relative immune privilege and immunosuppressive and tolerogenic properties. Preclinical studies in models of obliterative bronchiolitis and human trials in graft versus host disease and renal transplantation suggest potential efficacy in CLAD...
February 1, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28178923/non-neuronal-cholinergic-activity-is-potentiated-in-myasthenia-gravis
#4
Bin Han, Chao Zhang, Shoufeng Liu, Yiping Xia, Hao Sun, Zhongying Gong, Alain R Simard, Qiang Liu, Junwei Hao
BACKGROUND: Non-neuronal acetylcholine (ACh) restricts autoimmune responses and attenuates inflammation by cholinergic anti-inflammation pathway. To date, the implication of ACh in myasthenia gravis (MG) remained unexplored. This study aimed to investigate the possible relationship between ACh levels, anti-muscle-specific tyrosine kinase (MuSK) antibody titers, main clinical features and outcomes of MG patients. METHODS: We successfully measured ACh levels in human peripheral blood mononuclear cells (PBMCs) from 125 MG patients and 50 matched healthy controls by using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
February 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28174340/genetic-variants-affecting-cross-sectional-lung-function-in-adults-show-little-or-no-effect-on-longitudinal-lung-function-decline
#5
Catherine John, María Soler Artigas, Jennie Hui, Sune Fallgaard Nielsen, Nicholas Rafaels, Peter D Paré, Nadia N Hansel, Nick Shrine, Iain Kilty, Anders Malarstig, Scott A Jelinsky, Signe Vedel-Krogh, Kathleen Barnes, Ian P Hall, John Beilby, Arthur W Musk, Børge G Nordestgaard, Alan James, Louise V Wain, Martin D Tobin
BACKGROUND: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be defined. OBJECTIVES: We aimed to determine whether regions associated with cross-sectional lung function were also associated with longitudinal decline and to seek novel variants which influence decline. METHODS: We analysed genome-wide data from 4167 individuals from the Busselton Health Study cohort, who had undergone spirometry (12 695 observations across eight time points)...
February 7, 2017: Thorax
https://www.readbyqxmd.com/read/28174114/health-risk-benefit-information-for-consumers-of-fish-and-shellfish-fishchoice-a-new-online-tool
#6
Lolita Vilavert, Ferran Borrell, Martí Nadal, Silke Jacobs, Fien Minnens, Wim Verbeke, António Marques, José Luis Domingo
It is well known that due to the content in omega-3 fatty acids, consumption of fish and shellfish is beneficial for human cardiovascular health. However, a number of recent studies have shown that fish consumption may be also a potential dietary source of exposure to various environmental pollutants with well-known potential adverse effects on human health. Moreover, there is still a lack of information regarding levels of emerging contaminants in fish and shellfish, in particular among consumers and stakeholders...
February 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28164324/rituximab-treatment-of-myasthenia-gravis-a-systematic-review
#7
REVIEW
Rup Tandan, Michael K Hehir, Waqar Waheed, Diantha B Howard
Rituximab is a chimeric mouse/human anti-CD20 monoclonal immunoglobulin. We reviewed the efficacy and safety of rituximab in 169 myasthenia gravis (MG) patients from case reports and series. Antibodies to the acetylcholine receptor (AChR) were present in 59% and muscle specific tyrosine kinase (MuSK) in 34%. Modified Myasthenia Gravis Foundation of America post-intervention scale of minimal manifestations (MM) occurred in 44%, and combined pharmacological and chronic stable remission in 27% overall; MM or better was achieved in 72% of MuSK MG and 30% of AChR MG (P<0...
February 6, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28154466/nasopharyngeal-temperature-measurement-in-sheep-during-general-anesthesia
#8
Tabita Tan, Jonathon Tuke, Gabrielle C Musk
The aim of this study was to compare nasopharyngeal and esophageal temperature measurements in anesthetized sheep with a range of fresh gas flows (1 to 6 L/min) through the breathing system. Data were compared using a Bland-Altman plot and correlation coefficients, and error measures were calculated. One hundred and ninety-five sets of data were collected from 20 sheep weighing 41 kg (31 to 51.5 kg). The bias (95% limit of agreement), correlation coefficient, and absolute error for nasopharyngeal compared to esophageal temperature were 0...
January 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28145478/comparison-of-amino-acid-profiles-and-metabolic-gene-expression-in-muskrat-scented-glands-in-secretion-and-non-secretion-season
#9
Yimeng Li, Tianxiang Zhang, Mengyuan Fan, Juntong Zhou, Shuang Yang, Meishan Zhang, Lei Qi, Shaobi Lin, Defu Hu, Shuqiang Liu
The scented gland is an organ responsible for producing musk in muskrats. During musk secretion season, the metabolism of glandular cells increases in the scented glands and a large amount of musk is synthesised. In this study, we collected scented gland arterial blood from six healthy adult male muskrats during non-secretion season (November). We also obtained scented gland arterial blood, venous blood, and musk from six healthy adult males during secretion season (March). Qualitative and quantitative analyses of free amino acids in blood and musk were performed with an automated amino acid analyzer...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129620/in%C3%A2-vitro-determination-of-transdermal-permeation-of-synthetic-musks-and-estimated-dermal-uptake-through-usage-of-personal-care-products
#10
Xiaolan Zhang, Yuling Yu, Yue Gu, Xiaojing Li, Xinyu Zhang, Yingxin Yu
Synthetic musks, chemical constituents of personal care products, enter the human body through dermal contact. Elucidation of the mechanisms underlying transdermal permeation of synthetic musks should enhance our understanding of their uptake and distribution in human skin and allow accurate evaluation of associated human exposure. Here, the transdermal permeation dynamics and distribution of galaxolide (HHCB) and tonalide (AHTN) were investigated using an in vitro skin diffusion model. The transdermal permeation amounts of HHCB and AHTN increased rapidly during the first 6 h...
January 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/28127106/comparative-anatomy-of-gastrin-releasing-peptide-pathways-in-the-trigeminal-sensory-system-of-mouse-and-the-asian-house-musk-shrew-suncus-murinus
#11
Keiko Takanami, Kaihei Inoue, Hiroki Mukai, Kei Tamura, Takamichi Jogahara, Sen-Ichi Oda, Mitsuhiro Kawata, Tatsuya Sakamoto, Hirotaka Sakamoto
Gastrin-releasing peptide (GRP) has recently been identified as an itch-signaling molecule in the primary afferents and spinal cord of rodents. However, little information exists on the expression and localization of GRP in the trigeminal somatosensory system other than in rats. We examined the generality of the trigeminal GRP system in mammals using two distinct species, suncus as a model of specialized placental mammals known to have a well-developed trigeminal sensory system and mice as a representative small laboratory animal...
December 28, 2016: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/28120411/electrical-stimulation-delays-reinnervation-in-denervated-rat-muscle
#12
Clara M Pinheiro-Dardis, Bruna T Erbereli, Davilene Gigo-Benato, Paula A T S Castro, Thiago L Russo
INTRODUCTION: It is not clear if electrical stimulation (ES) can affect muscle reinnervation. This study aimed to verify if ES affects neuromuscular recovery after nerve crush injury in rats. METHODS: Denervated muscles were electrically stimulated daily for 6 or 14 days. Neuromuscular performance and excitability, and muscle morphology were determined. Muscle trophism markers (atrogin-1, MuRF-1, and myoD), as well as neuromuscular junction (NMJ) organization (MuSK, Dok-7, nAChR, and N-CAM) were assessed...
January 24, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28120340/anti-lrp4-autoantibodies-in-chinese-patients-with-myasthenia-gravis
#13
Yuan Li, Yifan Zhang, Gang Cai, Dian He, Qingqing Dai, Zhu Xu, Lan Chu
: Instruction: We assessed antibodies against low-density lipoprotein receptor-related protein 4 (LRP4-Ab) in a Chinese population with myasthenia gravis (MG). METHODS: Serum samples from 116 patients and 80 controls were collected. Acetylcholine receptor antibodies(AChR-Ab) and muscle-specific receptor tyrosine kinase antibodies(MuSK-Ab) were tested using an enzyme-linked immune absorption assay, and LRP4-Ab was identified using a cell-based assay. MG patients with neither AChR-Ab nor MuSK-Ab were defined as double-seronegative MG (dSN-MG)...
January 24, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28107935/tetraphasic-polar-organic-chemical-integrative-sampler-for-the-determination-of-a-wide-polarity-range-organic-pollutants-in-water-the-use-of-performance-reference-compounds-and-in-situ-calibration
#14
A Iparraguirre, A Prieto, A Vallejo, M Moeder, O Zuloaga, N Etxebarria, A Paschke
In the present work, a homemade polar organic chemical integrative sampler (POCIS) was studied for the determination of 16 target analytes. The suitability of the combination of triphasic mixture (used in so called pesticides-POCIS) and octadecyl-functionalized silica gel (C18) as sorbent for POCIS was evaluated for the determination of alkylphenols (APs), several hormones, bisphenol-A (BPA), synthetic musk fragrances and herbicides such as trifluralin (Tri) and alachlor (Ala). With this purpose, POCIS laboratory calibration study, using a continuous-flow calibration system, was carried out in order to determine the uptake behavior and sampling rate (Rs) values for each target analyte...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28087666/dysregulation-of-b-cell-repertoire-formation-in-myasthenia-gravis-patients-revealed-through-deep-sequencing
#15
Jason A Vander Heiden, Panos Stathopoulos, Julian Q Zhou, Luan Chen, Tamara J Gilbert, Christopher R Bolen, Richard J Barohn, Mazen M Dimachkie, Emma Ciafaloni, Teresa J Broering, Francois Vigneault, Richard J Nowak, Steven H Kleinstein, Kevin C O'Connor
Myasthenia gravis (MG) is a prototypical B cell-mediated autoimmune disease affecting 20-50 people per 100,000. The majority of patients fall into two clinically distinguishable types based on whether they produce autoantibodies targeting the acetylcholine receptor (AChR-MG) or muscle specific kinase (MuSK-MG). The autoantibodies are pathogenic, but whether their generation is associated with broader defects in the B cell repertoire is unknown. To address this question, we performed deep sequencing of the BCR repertoire of AChR-MG, MuSK-MG, and healthy subjects to generate ∼518,000 unique VH and VL sequences from sorted naive and memory B cell populations...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28079665/anesthetic-management-of-a-patient-with-antimuscle-specific-kinase-antibody-positive-myasthenia-gravis-undergoing-an-open-cholecystectomy-a-case-report
#16
Masahiko Akatsu, Yukihiro Ikegami, Choichiro Tase, Koichi Nishikawa
Myasthenia gravis (MG) is an autoimmune disease characterized by the production of antibodies against the acetylcholine receptor, muscle-specific kinase (MuSK), or other proteins at the neuromuscular junction. MG with antibodies against MuSK (MuSK-MG) has been described recently. Here, we report the first case of anesthetic management of a patient with MuSK-MG undergoing an open cholecystectomy. In our case, propofol and remifentanil-based anesthesia were used for successful management without using muscle relaxants...
January 11, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28079271/uptake-and-elimination-kinetics-of-the-biocide-triclosan-and-the-synthetic-musks-galaxolide-and-tonalide-in-the-earthworm-dendrobaena-veneta-when-exposed-to-sewage-sludge
#17
Ivo Havranek, Claire Coutris, Hans Ragnar Norli, Pierre-Adrien Rivier, Erik J Joner
Sewage sludge is an important amendment that enriches soils with organic matter and provides plants with nutrients such as nitrogen and phosphorus. However, knowledge on fate and effects of organic pollutants present in the sludge on soil organisms is limited. In the present study, the uptake of triclosan, galaxolide, and tonalide in the earthworm Dendrobaena veneta was measured one week after amendment of agricultural soil with sewage sludge, while elimination kinetics were assessed over a 21-day period after transferring worms to a clean soil...
January 12, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28072465/splicing-regulation-and-dysregulation-of-cholinergic-genes-expressed-at-the-neuromuscular-junction
#18
REVIEW
Kinji Ohno, Mohammad Alinoor Rahman, Mohammad Nazim, Farhana Nasrin, Yingni Lin, Jun-Ichi Takeda, Akio Masuda
We humans have evolved by acquiring diversity of alternative RNA metabolisms including alternative means of splicing and transcribing non-coding genes, and not by acquiring new coding genes. Tissue-specific and developmental stage-specific alternative RNA splicing is achieved by tightly regulated spatiotemporal regulation of expressions and activations of RNA-binding proteins that recognize their cognate splicing cis-elements on nascent RNA transcripts. Genes expressed at the neuromuscular junction (NMJ) are also alternatively spliced...
January 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28069867/the-carboxyl-terminal-region-of-dok-7-plays-a-key-but-not-essential-role-in-activation-of-muscle-specific-receptor-kinase-musk-and-neuromuscular-synapse-formation
#19
Ryo Ueta, Tohru Tezuka, Yosuke Izawa, Sadanori Miyoshi, Satoru Nagatoishi, Kouhei Tsumoto, Yuji Yamanashi
As the synapse between a motor neuron and skeletal muscle, the neuromuscular junction (NMJ) is required for muscle contraction. The formation and maintenance of NMJs are controlled by the muscle-specific receptor kinase MuSK. Dok-7 is the essential cytoplasmic activator of MuSK, and indeed mice lacking Dok-7 form no NMJs. Moreover, DOK7 gene mutations underlie DOK7 myasthenia, an NMJ synaptopathy. Previously, we failed to detect MuSK activation in myotubes by Dok-7 mutated in the N-terminal pleckstrin homology (PH) or phosphotyrosine binding (PTB) domain or that lacked the C-terminal region (Dok-7-ΔC)...
January 7, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28042656/the-emetic-activity-of-staphylococcal-enterotoxins-sek-sel-sem-sen-and-seo-in-a-small-emetic-animal-model-house-musk-shrew
#20
Hisaya K Ono, Shouhei Hirose, Ikunori Naito, Yusuke Sato'o, Krisana Asano, Dong-Liang Hu, Katsuhiko Omoe, Akio Nakane
Staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus are the most recognizable causative agents of emetic food poisoning in humans. New types of SEs and SE-like (SEl) toxins have been reported. Several epidemiological investigations have shown that the SEs and SEls genes, particularly, SEK, SEL, SEM, SEN and SEO genes, were highly detected in the strains isolated from food poisoning cases. The purpose of the present study was to evaluate the emetic activity of the recently identified SEs using a small emetic animal model, house musk shrew...
January 2, 2017: Microbiology and Immunology
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