keyword
MENU ▼
Read by QxMD icon Read
search

recurrence colon cancer

keyword
https://www.readbyqxmd.com/read/28915716/implementation-and-utilization-of-the-molecular-tumor-board-to-guide-precision-medicine
#1
REVIEW
Shuko Harada, Rebecca Arend, Qian Dai, Jessica A Levesque, Thomas S Winokur, Rongjun Guo, Martin J Heslin, Lisle Nabell, L Burt Nabors, Nita A Limdi, Kevin A Roth, Edward E Partridge, Gene P Siegal, Eddy S Yang
BACKGROUND: With rapid advances in genomic medicine, the complexity of delivering precision medicine to oncology patients across a university health system demanded the creation of a Molecular Tumor Board (MTB) for patient selection and assessment of treatment options. The objective of this report is to analyze our progress to date and discuss the importance of the MTB in the implementation of personalized medicine. MATERIALS AND METHODS: Patients were reviewed in the MTB for appropriateness for comprehensive next generation sequencing (NGS) cancer gene set testing based on set criteria that were in place...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915207/risk-factors-and-oncologic-outcomes-of-anastomosis-leakage-after-laparoscopic-right-colectomy
#2
Han Deok Kwak, Seon-Hahn Kim, Dong Woo Kang, Se-Jin Baek, Jung Myun Kwak, Jin Kim
PURPOSE: We estimated the incidence of anastomosis leakage and explore possible risk factors and oncologic outcomes following laparoscopic right-side colon resection among colon cancer patients. MATERIALS AND METHODS: We retrospectively analyzed 423 patients who were diagnosed with appendiceal, cecal, ascending, or hepatic flexure colon cancer who underwent laparoscopic colonic resection and anastomosis between September 2006 and July 2014. We compared short-term and long-term outcomes between no-leakage and leakage groups...
September 14, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28913152/early-vulvar-and-umbilical-incisional-scar-recurrence-of-cervical-squamous-cell-carcinoma-earlier-than-usually-expected
#3
Hüseyin Çağlayan Özcan, Aynur Mustafa, Zehra Bozdağ, Seyhun Sucu, Mete Gürol Uğur, Özcan Balat
Cutaneous metastasis is considered as a hazardous condition depending on the mean survival around 9 months, which usually originates from cancers of the breast, lung, ovary, colon, and rarely from the cervix. The crucial prognostic factor of cutaneous metastasis depends on the period between the primary malignancy and cutaneous metastasis. We report two cases of the unusual presentation of squamous cell cancer of the cervix that developed vulvar and umbilical metastasis in the 5(th) month of primary treatment...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912842/a-reliable-method-for-the-sorting-and-identification-of-aldh-high-cancer-stem-cells-by-flow-cytometry
#4
Zhengwei Leng, Zhao Yang, Lifa Li, Xiaorong Zhong, He Zhou, Yong Li, Gang Yang, Guangjun Zhang, Yongfu Xiong, Tong Zhou, Jianshui Li, Dongsheng Wang, Jingdong Li
Cancer stem cells (CSCs) are a rare tumorigenic population of cells found in multiple types of cancer. It has been suggested that CSCs are responsible for cancer drug resistance, metastasis and recurrence. Therefore, it is important to develop techniques to correctly sort and identify CSCs. In the current study, the sorting and identification of aldehyde dehydrogenase high (ALDH(high)) CSCs was performed using flow cytometry. Cells from three colon cancer cell lines were cultured in serum-free medium to obtain CSCs-enriched spheroid cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912072/suprapubic-approach-for-robotic-complete-mesocolic-excision-in-right-colectomy-oncologic-safety-and-short-term-outcomes-of-an-original-technique
#5
W Petz, D Ribero, E Bertani, S Borin, G Formisano, S Esposito, G Spinoglio, P P Bianchi
INTRODUCTION: Right-sided colon cancer has a worse prognosis than left-sided colon cancer. Complete mesocolic excision (CME) with central vessels ligation (CVL) reduces local recurrence, but is technically demanding, particularly with a laparoscopic approach. Aim of this study is to describe a new robotic approach to right colectomy with CME and CVL and to report oncologic safety and short term outcomes. METHODS: Twenty consecutive patients were included. All patients had a right colon adenocarcinoma and underwent right colectomy with a suprapubic approach...
August 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28901407/colon-cancer-recurrence%C3%A2-associated-genes-revealed-by-wgcna-co%C3%A2-expression-network-analysis
#6
Xiaofeng Zhai, Qingfeng Xue, Qun Liu, Yuyu Guo, Zhe Chen
The present study aimed to identify the recurrence‑associated genes in colon cancer, which may provide theoretical evidence for the development of novel methods to prevent tumor recurrence. Colon cancer and matched normal samples microarray data (E‑GEOD‑39582) were downloaded from ArrayExpress. Genes with significant variation were identified, followed by the screening of differentially expressed genes (DEGs). Subsequently, the co‑expression network of DEGs was constructed using the weighted correlation network analysis (WGCNA) method, which was verified using the validation dataset...
August 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899736/characterization-of-genome-wide-copy-number-aberrations-in-colonic-mixed-adenoneuroendocrine-carcinoma-and-neuroendocrine-carcinoma-reveals-recurrent-amplification-of-ptger4-and-myc-genes
#7
Namita Sinha, Daniel Gaston, Daniel Manders, Marissa Goudie, Makoto Matsuoka, Tao Xie, Weei-Yuarn Huang
Colonic Mixed adenoneuroendocrine Carcinoma (MANEC) is an aggressive neoplasm with worse prognosis compared to adenocarcinoma. To gain a better understanding of the molecular features of colonic MANEC, we characterized the genome-wide copy number aberrations (CNA) of 14 MANECs and 5 neuroendocrine carcinomas using the OncoScan FFPE assay. Compared to 269 colonic adenocarcinomas, 19 of 42 chromosomal arms of MANEC exhibited a similar frequency of major aberrant events as adenocarcinomas, and 13 chromosomal arms exhibited a higher frequency of copy number gains...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28893260/long-lasting-complete-response-status-of-advanced-stage-iv-gall-bladder-cancer-and-colon-cancer-after-combined-treatment-including-autologous-formalin-fixed-tumor-vaccine-two-case-reports
#8
Yuki Imaoka, Fumito Kuranishi, Tsubasa Miyazaki, Hiroko Yasuda, Tadao Ohno
BACKGROUND: The prognosis of advanced (stage IV) cancer of the digestive organs is very poor. We have previously reported a case of advanced breast cancer with bone metastasis that was successfully treated with combined treatments including autologous formalin-fixed tumor vaccine (AFTV). Herein, we report the success of this approach in advanced stage IV (heavily metastasized) cases of gall bladder cancer and colon cancer. CASE PRESENTATION: Case 1: A 61-year-old woman with stage IV gall bladder cancer (liver metastasis and lymph node metastasis) underwent surgery in May 2011, including partial resection of the liver...
September 11, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28886423/molecular-imaging-of-colorectal-tumors-by-targeting-colon-cancer-secreted-protein-2-ccsp-2
#9
Jaeil Kim, Eun-Ju Do, Helen Moinova, Sang Mun Bae, Ja Young Kang, Seung-Mo Hong, Stephen P Fink, Jinmyoung Joo, Young-Ah Suh, Se Jin Jang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Jaewon Choe, Suk-Kyun Yang, Sanford D Markowitz, Sang-Yeob Kim, Seung-Jae Myung
A versatile biomarker for detecting colonic adenoma and colon cancer has yet to be developed. Colon cancer secreted protein-2 (CCSP-2) is a protein specifically expressed and secreted in colon adenomas and cancers. We developed a fluorescent imaging method based on CCSP-2 targeting for a more sensitive and specific detection of colorectal tumors. CCSP-2 expression was evaluated in human colon adenoma and colorectal specimens. Anti-CCSP-2 antibody was labeled with a near-infrared fluorescent dye, FPR-675, and molecular imaging of surgical human colorectal tumors was performed...
September 4, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28881655/dna-hypomethylation-of-cbs-promoter-induced-by-folate-deficiency-is-a-potential-noninvasive-circulating-biomarker-for-colorectal-adenocarcinomas
#10
Geng Xue, Chao-Jing Lu, Shu-Jun Pan, Yin-Ling Zhang, Hui Miao, Shi Shan, Xiao-Ting Zhu, Yi Zhang
Aberrant DNA methylation patterns, which induced by folate deficiency, play important roles in tumorigenesis of colorectal cancer (CRC). Some DNA methylation alterations can also be detected in cell-free DNA (cfDNA) of patients' plasma, making cfDNA an ideal noninvasive circulating biomarker. However, exact DNA methylation alterations induced by folate deficiency in tumorigenesis of CRC and exact potential circulating cfDNA methylation biomarker are still unclear. Therefore, DNA methylation patterns of the normal human colon mucosal epithelial cell line (NCM460), cultured with normal or low folate content, were screened and the DNA hypomethylation of cystathionine-beta-synthase (CBS) promoter was further validated in vitro and vivo...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881576/inhibition-of-pi3k-akt-mtor-signaling-in-pi3kr2-overexpressing-colon-cancer-stem-cells-reduces-tumor-growth-due-to-apoptosis
#11
Sugong Chen, Robert C Fisher, Steven Signs, L Alex Molina, Anitha K Shenoy, Maria-Cecilia Lopez, Henry V Baker, John M Koomen, Yi Chen, Haley Gittleman, Jill Barnholtz-Sloan, Annamarie Berg, Henry D Appelman, Emina H Huang
In sporadic colon cancer, colon cancer stem cells (CCSCs) initiate tumorigenesis and may contribute to late disease recurrences and metastases. We previously showed that aldehyde dehydrogenase (ALDH) activity (as indicated by the ALDEFLUOR(®) assay) is an effective marker for highly enriching CCSCs for further evaluation. Here, we used comparative transcriptome and proteome approaches to identify signaling pathways overrepresented in the CCSC population. We found overexpression of several components of the phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway, including PI3KR2, a regulatory subunit of PI3K...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878843/prognostic-relevance-of-an-epigenetic-biomarker-panel-in-sentinel-lymph-nodes-from-colon-cancer-patients
#12
Guro E Lind, Marianne Guriby, Terje Ahlquist, Israr Hussain, Marine Jeanmougin, Kjetil Søreide, Hartwig Kørner, Ragnhild A Lothe, Oddmund Nordgård
BACKGROUND: Patients with early colorectal cancer (stages I-II) generally have a good prognosis, but a subgroup of 15-20% experiences relapse and eventually die of disease. Occult metastases have been suggested as a marker for increased risk of recurrence in patients with node-negative disease. Using a previously identified, highly accurate epigenetic biomarker panel for early detection of colorectal tumors, we aimed at evaluating the prognostic value of occult metastases in sentinel lymph nodes of colon cancer patients...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28878651/ischemic-colitis-associated-with-paclitaxel-and-carboplatin-combination
#13
Ahmed Gamal Elsayed, Roma Srivastava, Toni Pacioles, Teresa Limjoco, Maria Tria Tirona
A 62-year-old white female with a history of early-stage triple-negative breast cancer on a combination of carboplatin and paclitaxel in the adjuvant setting presented with lower gastrointestinal bleeding. She tolerated 4 cycles of dose-dense adriamycin/cyclophosphamide with no major symptoms. After 6 cycles of weekly paclitaxel in combination with carboplatin every 3 weeks, she presented with diarrhea and lower gastrointestinal bleeding. Colonosopic examination showed erythema and inflammation in the splenic flexure, descending colon, and sigmoid colon consistent with ischemic colitis...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28876656/colorectal-cancer-is-there-an-association-between-hiv-infection-and-the-clinicopathological-picture
#14
S K Pillay, Z Moolla, B Sartorius, T E Madiba
BACKGROUND: The link between colorectal cancer (CRC) and HIV has not been extensively studied. METHOD: Study setting: Colorectal unit at a tertiary institution. Study population: HIV negative and positive patients with colorectal cancer over 12 years (2005-2016). Study design: This is an analysis of prospectively collected data from a colorectal cancer database archived in the Gastrointestinal Cancer Research Centre, University of KwaZulu-Natal. Demographic details, HIV status, anatomical site, stage, treatment and follow-up were documented...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28869500/using-na%C3%A3-ve-bayesian-analysis-to-determine-imaging-characteristics-of-kras-mutations-in-metastatic-colon-cancer
#15
Yash Pershad, Siddharth Govindan, Amy K Hara, Mitesh J Borad, Tanios Bekaii-Saab, Alex Wallace, Hassan Albadawi, Rahmi Oklu
Genotype, particularly Ras status, greatly affects prognosis and treatment of liver metastasis in colon cancer patients. This pilot aimed to apply word frequency analysis and a naive Bayes classifier on radiology reports to extract distinguishing imaging descriptors of wild-type colon cancer patients and those with v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations. In this institutional-review-board-approved study, we compiled a SNaPshot mutation analysis dataset from 457 colon adenocarcinoma patients...
September 2, 2017: Diagnostics
https://www.readbyqxmd.com/read/28868482/self-expandable-metal-stents-for-colorectal-cancer-from-guidelines-to-clinical-practice
#16
Maria Pia Costa Santos, Carolina Palmela, Rosa Ferreira, Elídio Barjas, António Alberto Santos, Rui Maio, Marília Cravo
INTRODUCTION: Colonic self-expandable metal stent placement is widely used for palliation of obstructive colorectal cancer. The European recommendations for stent placement as a bridge to elective surgery in obstructive colorectal cancer were recently reviewed. The aim of this study was to evaluate the efficacy and safety of stent placement in obstructive colorectal cancer and to discuss these recent guidelines. MATERIALS AND METHODS: Demographic characteristics, procedure indications, complications and final outcome in patients with obstructive colorectal cancer who underwent endoscopic stent placement between January 2012 and June 2015 were retrospectively analyzed...
November 2016: GE Port J Gastroenterol
https://www.readbyqxmd.com/read/28862125/solitary-adrenal-metastases-from-breast-invasive-ductal-carcinoma
#17
Cezar Stroescu, Iulian Gilca, Dragoş Chirita, Radu Poenaru, Ana Puşcaşu, Diana Pescaru, Adelina Birceanu, Cornelia Niţipir, Narcis Copcă
The usual neoplastic dissease involving suprarenal glands are adrenal metastaes. The majority of suprarenal metastatic disease arise from lung cancer, followed by the stomach and colon cancer, oesophagus, the liver/bile ducts cancer and renal cell carcinoma. Invasive mammary carcinoma usually spreads to the bones, lungs, lymph nodes, liver and the brain. Adrenal gland metastases from invasive no special type carcinoma represents an extremly low rate number of cases. We discuss about a 66 year old patient who presented with a solitary adrenal metastases from triple negative breast invasive carcinoma...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28854900/vegfr2-regulates-endothelial-differentiation-of-colon-cancer-cells
#18
Zhiyong Liu, Lisha Qi, Yixian Li, Xiulan Zhao, Baocun Sun
BACKGROUND: Recent studies suggested that cancer stem-like cells contribute to tumor vasculogenesis by differentiating into endothelial cells. However, such process is governed by still undefined mechanism. METHODS: At varying differentiation levels, three representative colon cancer cells were cultured in endothelial-inducing conditioned medium: human colon cancer cells HCT116 (HCT116) (poorly differentiated), SW480 (moderately differentiated), and HT29 (well differentiated)...
August 30, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28841901/outcome-of-colon-cancer-initially-presenting-as-colon-perforation-and-obstruction
#19
Tsung-Ming Chen, Yen-Ta Huang, Guan-Chyuan Wang
BACKGROUND: Emergency complications of colon cancer include perforation and obstruction which were recognized as poor prognostic factors. Few studies have directly compared the outcomes of these two groups. In this study, we evaluated mortality and morbidity in patients with colon cancer initially presenting as perforation and obstruction. METHODS: Newly diagnosed colon cancer cases initially presenting with perforation or obstruction at Tzu Chi General Hospital, Hualien, Taiwan, between 2009 and 2015 were included...
August 25, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28838457/coexistent-end-stage-nonalcoholic-steatohepatitis-and-colon-cancer-should-we-do-liver-transplantation
#20
V Aliyev, K Yasuchika, A Hammad, A Badawy, Y Nigmet, T Tajima, K Fukumitsu, S Yagi, K Hata, H Okajima, S Uemoto
BACKGROUND: Colon cancer accompanying decompensated liver cirrhosis is a rare clinical condition. Usually, treatment of colon cancer is prioritized, with cirrhosis dealt with later. CASE REPORT: We present a case of end-stage liver disease due to nonalcoholic steatohepatitis evaluated for living donor liver transplant. During the pretransplant examination, an ascending colon cancer was detected. Liver function was too poor to perform colon resection first. Simultaneous living donor liver transplant and colonic resection were carried out...
September 2017: Transplantation Proceedings
keyword
keyword
57073
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"