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https://www.readbyqxmd.com/read/28329650/increased-risk-of-opportunistic-infections-among-patients-with-moderate-to-severe-psoriasis-a-population-based-cohort-study-in-the-united-kingdom
#1
Junko Takeshita, Daniel B Shin, Alexis Ogdie, Joel M Gelfand
Infection is the second leading cause of death among psoriasis patients on phototherapy or systemic medications. The types of infections associated with psoriasis remain poorly understood. The aim of our study was to determine the risk of opportunistic infection (OI) among patients with psoriasis. We conducted a cohort study of patients with (N=199,700) and without (N=954,315) psoriasis in The Health Improvement Network electronic medical record database. Patients receiving phototherapy or systemic therapy were considered to have moderate-to-severe psoriasis (N=12,442)...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28321466/the-risk-and-clinical-outcome-of-candidemia-depending-on-underlying-malignancy
#2
Olivier Lortholary, Charlotte Renaudat, Karine Sitbon, Marie Desnos-Ollivier, Stéphane Bretagne, Françoise Dromer
PURPOSE: To assess the risk factors and outcomes associated with fungemia caused by the six most commonly occurring Candida species in patients with and without malignancies. METHODS: Analysis of the episodes of fungemia due to common Candida species in adults, based on an active hospital-based surveillance program (Paris area, France, 2002 to 2014). RESULTS: Of the 3417 patients (3666 isolates), 1164 (34.1%) had a solid tumor (45.7% digestive tract) and 586 (17...
March 20, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28296161/passive-vectoring-of-entomopathogenic-fungus-beauveria-bassiana-among-the-wax-moth-galleria-mellonella-larvae-by-the-ectoparasitoid-habrobracon-hebetor-females
#3
Vadim Yu Kryukov, Natalia A Kryukova, Maksim V Tyurin, Olga N Yaroslavtseva, Viktor V Glupov
Females of the ectoparasitoid Habrobracon hebetor attack and envenomate numerous host individuals during oviposition. The vectoring of the entomopathogenic fungus Beauveria bassiana during the adhesion stage by ectoparasitoid females among the wax moth larvae Galleria mellonella was explored under laboratory conditions. Vectoring occurred both from infected parasitoids to wax moth larvae and from infected to healthy wax moth larvae by parasitoids. The efficacy of vectoring in both cases was dose dependent. Parasitoid females were unable to recognize infected larvae in a labyrinth test...
March 15, 2017: Insect Science
https://www.readbyqxmd.com/read/28295235/cutaneous-manifestations-of-subcutaneous-and-systemic-fungal-infections-in-tropical-regions-a-retrospective-study-from-a-referral-center-in-southern-taiwan
#4
Wen-Chien Tsai, Chih-Hung Lee, Wei-Min Wu, Shang-Hung Lin, Yi-Chien Yang, Yu-Wen Cheng, Ji-Chen Ho, Kwei-Lan Liu
BACKGROUND: Deep cutaneous fungal infections, including subcutaneous mycoses and systemic fungal infection with cutaneous involvement, cause significant morbidity and mortality in light of increasing immunocompromised patients and global warming. Although a few studies reviewed deep fungal infections in temperate regions, a relevant study in tropical regions is lacking. We evaluated features of deep cutaneous fungal infections in southern Taiwan among the tropical regions. METHODS: We retrospectively reviewed all histopathological specimens with deep cutaneous fungal infections in a single referral center from 2001 to 2014 and successfully identified 23 cases...
March 13, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28293759/serious-fungal-diseases-in-the-republic-of-uzbekistan
#5
S A Tilavberdiev, D W Denning, N N Klimko
We have undertaken the first and preliminary estimation of severe and chronic mycotic diseases in the Republic of Uzbekistan, using a model proposed by LIFE (Leading International Fungal Education). Calculation was carried out based on data from 2014. Published results describing mycoses in Uzbekistan were identified. In the absence of published or official data, information about the frequency of mycoses from scientific literature elsewhere in groups at risk of development of fungal infections were taken into account...
March 14, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28264518/synthesis-x-ray-single-crystal-structure-molecular-docking-and-dft-computations-on-n-1e-1-2h-1-3-benzodioxol-5-yl-3-1h-imidazol-1-yl-propylidene-hydroxylamine-a-new-potential-antifungal-agent-precursor
#6
Reem I Al-Wabli, Alwah R Al-Ghamdi, Hazem A Ghabbour, Mohamed H Al-Agamy, James Clemy Monicka, Issac Hubert Joe, Mohamed I Attia
Mycoses are serious health problem, especially in immunocompromised individuals. A new imidazole-bearing compound containing an oxime functionality was synthesized and characterized with different spectroscopic techniques to be used for the preparation of new antifungal agents. The stereochemistry of the oxime double bond was unequivocally determined via the single crystal X-ray technique. The title compound 4, C13H13N₃O₃·C₃H₈O, crystallizes in the monoclinic space group P2₁with a = 9.0963(3) Å, b = 14...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28242238/the-burden-of-facial-cellulitis-leading-to-inpatient-hospitalization
#7
Shelly Abramowicz, Sankeerth Rampa, Veerasathpurush Allareddy, Min Kyeong Lee
PURPOSE: The purpose of the present study was to present nationally representative estimates of hospitalizations primarily attributed to facial cellulitis and to conduct an exploratory analysis on identifying factors associated with outcomes, such as hospital charges, length of stay (LOS), disposition status, and occurrence of infectious complications. MATERIALS AND METHODS: The present study is a retrospective analysis of the Nationwide Inpatient Sample (NIS) for 2012 and 2013...
February 3, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28236353/evaluation-of-growth-conditions-and-dna-extraction-techniques-used-in-the-molecular-analysis-of-dermatophytes
#8
Sebastian Gnat, Aneta Nowakiewicz, Grażyna Ziółkowska, Aleksandra Trościańczyk, Barbara Majer-Dziedzic, Przemysław Zięba
AIMS: Recent molecular methods for diagnosis of superficial mycoses have determined the need for a rapid and easy method of extracting DNA. The aim of study was to determine growth conditions and techniques of DNA extraction for Microsporum canis, Trichophyton mentagrophytes, and T. verrucosum. METHODS AND RESULTS: Samples were prepared of each of the DNA extraction methods (phenol-chloroform, CTAB, and four different kits) for all of the incubation periods (four, seven, and 10 d) of the cultures on the solid and in the liquid medium...
February 25, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28220547/identification-and-molecular-epidemiology-of-dermatophyte-isolates-by-repetitive-sequence-pcr-based-dna-fingerprinting-using-the-diversilab-system-in-turkey
#9
A Nedret Koc, Mustafa A Atalay, Melek Inci, Fatma M Sariguzel, Hafize Sav
Dermatophyte species, isolation and identification in clinical samples are still difficult and take a long time. The identification and molecular epidemiology of dermatophytes commonly isolated in a clinical laboratory in Turkey by repetitive sequence-based PCR (rep-PCR) were assessed by comparing the results with those of reference identification. A total of 44 dermatophytes isolated from various clinical specimens of 20 patients with superficial mycoses in Kayseri and 24 patients in Hatay were studied. The identification of dermatophyte isolates was based on the reference identification and rep-PCR using the DiversiLab System (BioMerieux)...
February 21, 2017: Mycoses
https://www.readbyqxmd.com/read/28218019/nucleic-acid-amplification-methodologies-for-the-detection-of-pulmonary-mold-infections
#10
Matthew William McCarthy, Ruta Petraitiene, Thomas J Walsh
The detection of pulmonary mold infections has historically required technically demanding methods obtained through invasive procedures. Nucleic acid amplification assays have the potential to circumvent the technical hurdles associated with diagnosis, but are not without potential pitfalls. Areas covered: In this paper, the authors review new assays for the diagnosis of pulmonary mold infections due to aspergillosis, mucormycosis, and hyalohyphomycoses as well as uncommon infections caused by dematiaceous molds...
March 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28217816/candida-albicans-survival-growth-and-biofilm-formation-are-differently-affected-by-mouthwashes-an-in-vitro-study
#11
Simona Paulone, Giulia Malavasi, Andrea Ardizzoni, Carlotta Francesca Orsi, Samuele Peppoloni, Rachele Giovanna Neglia, Elisabetta Blasi
Candida albicans is the most common cause of oral mycoses. The aim of the present study was to investigate in vitro the susceptibility of C. albicans to mouthwashes, in terms of growth, survival and biofilm formation. Candida albicans, laboratory strain SC5314, and 7 commercial mouthwashes were employed: 3 with 0.2% chlorhexidine digluconate; 1 with 0.06% chlorhexidine digluconate and 250 ppm F- sodium fluoride; 3 with fluorine-containing molecules. None of the mouthwashes contained ethanol in their formulations...
January 2017: New Microbiologica
https://www.readbyqxmd.com/read/28210571/unmasking-histoplasmosis-immune-reconstitution-inflammatory-syndrome-in-a-patient-recently-started-on-antiretroviral-therapy
#12
Reuben Kiggundu, Henry W Nabeta, Richard Okia, Joshua Rhein, Robert Lukande
Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. We report the case of a 43-year-old male who presented with cutaneous disseminated histoplasmosis due to Histoplasma capsulatum var. capsulatum 4 months after the onset of the antiretroviral therapy and some improvement in the immune reconstitution...
October 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/28205003/antifungal-efficacy-of-an-intravenous-formulation-containing-monomeric-amphotericin-b-5-fluorocytosine-and-saline-for-sodium-supplementation
#13
Celeste Alvarez, David R Andes, Jeong Yeon Kang, Carmen Krug, Glen S Kwon
PURPOSE: Amphotericin B (AmB) and 5-fluorocytosine (5-FC) exhibit additive to synergistic activity against systemic mycoses. Incompatibility of prescribed formulations precludes concomitant IV administration, a route with distinct advantages. Previously, we used PEG-DSPE micelles to produce a reformulation of Fungizone (AmB-SD), AmB solubilized by sodium deoxycholate, called mAmB-90. Herein, we describe a second reformulation that facilitates co-delivery of mAmB-90 and 5-FC, and evaluate the effect of PEG-DSPE micelles on the combination's activity against Candida albicans...
February 15, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28204502/changing-epidemiology-of-candidaemia-in-australia
#14
Belinda Chapman, Monica Slavin, Debbie Marriott, Catriona Halliday, Sarah Kidd, Ian Arthur, Narin Bak, Christopher H Heath, Karina Kennedy, C Orla Morrissey, Tania C Sorrell, Sebastian van Hal, Caitlin Keighley, Emma Goeman, Neil Underwood, Krispin Hajkowicz, Ann Hofmeyr, Michael Leung, Nenad Macesic, Jeannie Botes, Christopher Blyth, Louise Cooley, C Robert George, Pankaja Kalukottege, Alison Kesson, Brendan McMullan, Robert Baird, Jennifer Robson, Tony M Korman, Stella Pendle, Kerry Weeks, Eunice Liu, Elaine Cheong, Sharon Chen
No abstract text is available yet for this article.
February 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28194139/1-10-phenanthroline-5-6-dione-based-compounds-are-effective-in-disturbing-crucial-physiological-events-of-phialophora-verrucosa
#15
Marcela Queiroz Granato, Diego de Souza Gonçalves, Sergio Henrique Seabra, Malachy McCann, Michael Devereux, André Luis Souza Dos Santos, Lucimar Ferreira Kneipp
Phialophora verrucosa is a dematiaceous fungus able to cause chromoblastomycosis, phaeohyphomycosis and mycetoma. All these fungal diseases are extremely difficult to treat and often refractory to the current therapeutic approaches. Therefore, there is an urgent necessity to develop new antifungal agents to combat these mycoses. In this context, the aim of the present work was to investigate the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based derivatives [Ag(phendione)2]ClO4 = ([Ag(phendione)2](+)) and [Cu(phendione)3](ClO4)2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28194062/performance-of-galactomannan-antigen-beta-d-glucan-and-aspergillus-lateral-flow-device-for-the-diagnosis-of-invasive-aspergillosis
#16
Gökhan Metan, Muzaffer Keklik, Gökçen Dinç, Çiğdem Pala, Afra Yıldırım, Berkay Saraymen, Mustafa Yavuz Köker, Leylagül Kaynar, Bülent Eser, Mustafa Çetin
Aspergillus lateral-flow device (LFD) was recently introduced as a practical tool for the diagnosis of invasive aspergillosis (IA). We investigated the performance of Aspergillus-LFD as a point-of-care test for the diagnosis of IA. Serum samples were collected twice weekly from patients who received intensive chemotherapy for acute leukemia, or recepients of allogeneic stem cell transplantation. Aspergillus galactomannan (GM) antigen, 1,3-beta-d-glucan and Aspergillus-LFD tests were carried out according to manufacturers' recommendations...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28188605/-cancer-and-mycoses-and-literature-review
#17
M Develoux
Various infectious agents are classical risk factors for cancer including bacteria, viruses and parasites. There is less evidence concerning the implication of fungal infection in carcinogenesis. The role of chronic Candida infection in the development of squamous cell carcinoma has been suspected for years. Candida sp are more prevalent in potentially malignant disorder and cancer of the oral mucosa. Other epidemiological evidence of a link between Candida infection and cancer is what is observed in patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)...
February 11, 2017: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/28161745/serious-fungal-infections-in-canada
#18
S F Dufresne, D C Cole, D W Denning, D C Sheppard
There are currently no nationwide epidemiological data on fungal infections in Canada. We estimated the burden of serious fungal diseases using literature review and modeling, as per a methodology previously described by the LIFE program ( http://www.LIFE-worldwide.org ). Among the population of Canada (35.5 million in 2014), it was estimated that approximately 1.8% are affected by a serious fungal infection. Recurrent vulvovaginal candidiasis, severe asthma with fungal sensitization, and allergic bronchopulmonary aspergillosis are the most frequent infections, with population prevalences of 498,688 (1403/100,000), 73,344 (206/100,000), and 61,854 (174/100,000) cases, respectively...
February 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28161744/burden-of-serious-fungal-infections-in-bangladesh
#19
H C Gugnani, D W Denning, R Rahim, A Sadat, M Belal, M S Mahbub
In Bangladesh there are several published papers on superficial mycoses. Deep mycoses are also recognized as an important emerging problem. Here, we estimate the annual incidence and prevalence of serious fungal infections in Bangladesh. Demographic data were obtained from world population reports and the data on TB and HIV extracted from the online publications on tuberculosis in Bangladesh and Asia Pacific research statistical data information resources AIDS Data HUB. All the published papers on fungal infections in Bangladesh were identified through extensive search of literature...
February 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28161742/serious-fungal-infections-in-thailand
#20
M Chayakulkeeree, D W Denning
The burden of serious fungal infection in Thailand is increasing but data regarding its incidence and prevalence are lacking. In this study we aimed to estimate the burden of serious fungal diseases in Thailand based on the size of the populations at risk and available epidemiological databases. Data derived from The Bureau of Epidemiology, Department of Disease Control, Thai Ministry of Public Health, World Health Organisation, international and local reports, and some unreported data were used. When no data existed, risk populations were used to estimate frequencies of fungal infections, using previously described methodology by LIFE...
February 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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