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https://www.readbyqxmd.com/read/29330691/bis-guanylhydrazones-as-efficient-anti-candida-compounds-through-dna-interaction
#1
Jelena Lazić, Vladimir Ajdačić, Sandra Vojnovic, Mario Zlatović, Marina Pekmezovic, Selene Mogavero, Igor Opsenica, Jasmina Nikodinovic-Runic
Candida spp. are leading causes of opportunistic mycoses, including life-threatening hospital-borne infections, and novel antifungals, preferably aiming targets that have not been used before, are constantly needed. Hydrazone- and guanidine-containing molecules have shown a wide range of biological activities, including recently described excellent antifungal properties. In this study, four bis-guanylhydrazone derivatives (BG1-4) were generated following a previously developed synthetic route. Anti-Candida (two C...
January 12, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29325170/ecology-of-paracoccidioides-brasiliensis-p-lutzii-and-related-species-infection-in-armadillos-soil-occurrence-and-mycological-aspects
#2
Marluce Francisca Hrycyk, Hans Garcia Garces, Sandra de Moraes Gimenes Bosco, Sílvio Luis de Oliveira, Sílvio Alencar Marques, Eduardo Bagagli
Paracoccidioides brasiliensis and the related species P. americana, P. restrepiensis, P. venezuelensis, and P. lutzii (Ascomycota, Ajellomycetaceae) are the etiological agents of paracoccidoidoimycosis (PCM), one of the most important systemic mycoses in Latin America. They are dimorphic fungi, with a mycelial life cycle in soil and a yeast phase associated with tissues of mammalian hosts. This study aimed to detect Paracoccidioides spp. in armadillo tissues and associated soil samples in three well-defined geographic areas, including the Alta Floresta, an area not only endemic for PCM in the central region of Brazil but also of probable P...
January 6, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29313514/upper-gastrointestinal-tract-endoscopic-lesions-in-a-rural-african-hospitalo-252%C3%A2-endoscopies-at-the-kara-university-hospital-togo
#3
O Bouglouga, A Bagny, L M Lawson-Ananissoh, K Amanga, R El-Hadj Yakoubou, L Kaaga, M Djibril, D Redah
To analyze the indications for upper gastrointestinal endoscopy (UGIE) and determine the frequency of the pathological findings observed in rural areas of Africa. This retrospective study includes 9 series of 5-day visits to perform these examinations. Patients were informed of the presence of the endoscopy team by a bulletin on a rural radio station and by general practitioners at the Kara University Hospital. Patients were recruited from the hospital clinics and from the general population of the Kara region...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29304209/tolerability-profile-of-the-current-antifungal-armoury
#4
Ahmad Mourad, John R Perfect
The tolerability of available antifungal agents is essential to the final outcome of the management of invasive mycoses. There are limited classes of antifungal agents for use, and they can have serious direct toxicities and/or drug-drug interactions. In this review, we examine the common toxicities noted for antifungal agents and attempt to both identify the issues around the adverse events and provide clinical context for their occurrence in these fragile patients.
January 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29287097/standardization-and-validation-of-real-time-pcr-assays-for-the-diagnosis-of-histoplasmosis-using-three-molecular-targets-in-an-animal-model
#5
Luisa F López, César O Muñoz, Diego H Cáceres, Ángela M Tobón, Vladimir Loparev, Oliver Clay, Tom Chiller, Anastasia Litvintseva, Lalitha Gade, Ángel González, Beatriz L Gómez
Histoplasmosis is considered one of the most important endemic and systemic mycoses worldwide. Until now few molecular techniques have been developed for its diagnosis. The aim of this study was to develop and evaluate three real time PCR (qPCR) protocols for different protein-coding genes (100-kDa, H and M antigens) using an animal model. Fresh and formalin-fixed and paraffin-embedded (FFPE) lung tissues from BALB/c mice inoculated i.n. with 2.5x106 Histoplasma capsulatum yeast or PBS were obtained at 1, 2, 3, 4, 8, 12 and 16 weeks post-infection...
2017: PloS One
https://www.readbyqxmd.com/read/29261004/exploring-and-exploiting-the-connection-between-mitochondria-and-the-virulence-of-human-pathogenic-fungi
#6
Surbhi Verma, Viplendra P S Shakya, Alexander Idnurm
Mitochondria are best known for their role in the production of ATP; however, recent research implicates other mitochondrial functions in the virulence of human pathogenic fungi. Inhibitors of mitochondrial succinate dehydrogenase or the electron transport chain are successfully used to combat plant pathogenic fungi, but similar inhibition of mitochondrial functions has not been pursued for applications in medical mycology. Advances in understanding mitochondrial function relevant to human pathogenic fungi are in four major directions: 1) the role of mitochondrial morphology in virulence, 2) mitochondrial genetics, with a focus on mitochondrial DNA recombination and mitochondrial inheritance 3) the role of mitochondria in drug resistance, and 4) the interaction of mitochondria with other organelles...
December 20, 2017: Virulence
https://www.readbyqxmd.com/read/29239468/the-importance-of-risk-factors-for-the-prediction-of-patients-with-invasive-pulmonary-aspergillosis
#7
Selçuk Kaya, Eda Gençalioğlu, Mehmet Sönmez, Iftihar Köksal
OBJECTIVE: Invasive pulmonary aspergillosis (IPA) is a major challenge in the management of immunocompromised patients. Despite all the advances in diagnosis, it remains a problem. The purpose of our study was to investigate the risk factors associated with IPA seen in patients with hematological malignancies. METHOD: A total of 152 febrile neutropenia (FEN) patients with hematological malignancies aged over 18 years and receiving high-dose chemotherapy or stem cell transplant between January 1, 2010, and December 31, 2012 were included in the study...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29237128/host-control-of-fungal-infections-lessons-from-basic-studies-and-human-cohorts
#8
Michail S Lionakis, Stuart M Levitz
In the last few decades, the AIDS pandemic and the significant advances in the medical management of individuals with neoplastic and inflammatory conditions have resulted in a dramatic increase in the population of immunosuppressed patients with opportunistic, life-threatening fungal infections. The parallel development of clinically relevant mouse models of fungal disease and the discovery and characterization of several inborn errors of immune-related genes that underlie inherited human susceptibility to opportunistic mycoses have significantly expanded our understanding of the innate and adaptive immune mechanisms that protect against ubiquitous fungal exposures...
December 13, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/29188072/systemic-rasamsonia-piperina-infection-in-a-german-shepherd-cross-dog
#9
Joanna Lodzinska, Paola Cazzini, Claire S Taylor, Jenifer Harris, Scott Kilpatrick, Tiziana Liuti, Gavin K Paterson
Introduction. Infection with the Rasamsonia argillacea species complex represents an emerging problem in human and veterinary medicine with systemic mycoses presenting with significant clinical complications and being a cause of death. Case presentation. In this report, a case of systemic Rasamsonia piperina infection discovered in a 3-year-old male neutered, German shepherd cross dog is described together with the clinical presentation, the course of the disease and diagnosis. This report describes the first case of veterinary mycosis due to R...
October 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29187719/-small-animal-aspergillosis-and-cryptococcosis-in-japan
#10
Rui Kano
 Canine and feline upper respiratory tract (URT) infection due to Aspergillus spp. is considered an emerging disease, with the number of reported cases continuing to rise in Japan. Aspergillus fumigatus has been the most frequently reported etiologic agent of sino-orbital aspergillosis in dogs and cats; the other Aspergillus species, Aspergillus felis, Aspergillus fischeri, Aspergillus udagawae, Aspergillus viridinutans, and A. fumigatus, have also been implicated in feline cases. The minimum inhibitory concentrations (MICs) of antifungal drugs are elevated for these cryptic species compared with A...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29186267/incidence-of-skin-diseases-diagnosed-in-a-public-institution-comparison-between-2003-and-2014
#11
Livia Maria Zanardi Miguel, Marilia Formentini Scotton Jorge, Bruna Rocha, Hélio Amante Miot
Epidemiology of diseases is influenced by population socio-demographic circumstances. Therefore it can be modified along the time. There are no studies exploring epidemiological transition in dermatology. This study investigated the incidence of dermatoses in new patients from a Brazilian country town public service in 2003 and 2014. There was a significant increase in the incidence of sexually transmitted diseases, leprosy, melasma, pruritus and hidradenitis suppurativa. However, a prominent reduction in scheduling of appointments for surgeries of benign lesions, drug reactions, urticaria and superficial mycoses was detected...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29186263/white-piedra-black-piedra-tinea-versicolor-and-tinea-nigra-contribution-to-the-diagnosis-of-superficial-mycosis
#12
John Verrinder Veasey, Ricardo Bertozzi de Avila, Barbara Arruda Fraletti Miguel, Laura Hitomi Muramatu
Superficial mycoses are fungal infections restricted to the stratum corneum and to the hair shafts, with no penetration in the epidermis; they are: white piedra, black piedra, tinea versicolor, and tinea nigra. This study presents images of mycological tests performed in the laboratory, as well as exams performed at the authors office, in order to improve the dermatologist's knowledge about the diagnosis of these dermatoses, which are common in many countries.
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29164168/aids-related-endemic-mycoses-in-western-cape-south-africa-and-clinical-mimics-a-cross-sectional-study-of-adults-with-advanced-hiv-and-recent-onset-widespread-skin-lesions
#13
Ilan S Schwartz, Chris Kenyon, Rannakoe Lehloenya, Saskya Claasens, Zandile Spengane, Hans Prozesky, Rosie Burton, Arifa Parker, Sean Wasserman, Graeme Meintjes, Marc Mendelson, Jantjie Taljaard, Johann W Schneider, Natalie Beylis, Bonnie Maloba, Nelesh P Govender, Robert Colebunders, Sipho Dlamini
Background: Skin lesions are common in advanced HIV infection and are sometimes caused by serious diseases like systemic mycoses (SM). AIDS-related SM endemic to Western Cape, South Africa, include emergomycosis (formerly disseminated emmonsiosis), histoplasmosis, and sporotrichosis. We previously reported that 95% of patients with AIDS-related emergomycosis had skin lesions, although these were frequently overlooked or misdiagnosed clinically. Prospective studies are needed to characterize skin lesions of SM in South Africa and to help distinguish these from common HIV-related dermatoses...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29154044/modulating-host-immune-responses-to-fight-invasive-fungal-infections
#14
REVIEW
James E Scriven, Mark W Tenforde, Stuart M Levitz, Joseph N Jarvis
Modulation of host immunity in invasive fungal infection is an appealing but as yet mostly elusive treatment strategy. Animal studies in invasive candidiasis and aspergillosis have demonstrated beneficial effects of colony stimulating factors, interferon-gamma and monoclonal antibodies. More recent studies transfusing leukocytes pre-loaded with lipophilic anti-fungal drugs, or modulated T-cells, along with novel vaccination strategies show great promise. The translation of immune therapies into clinical studies has been limited to date but this is changing and the results of new Candida vaccine trials are eagerly awaited...
December 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29153538/oral-paracoccidioidomycosis-in-a-single-center-retrospective-analysis-from-a-brazilian-southeastern-population
#15
Laís Moreira Dutra, Thiago Humberto Mendonça Silva, Aloísio Falqueto, Paulo Mendes Peçanha, Lucia Renata Meireles Souza, Sarah Santos Gonçalves, Tânia Regina Grão Velloso
BACKGROUND: Paracoccidioidomycosis (PCM) is the most prevalent endemic systemic fungal infection in Latin America. In Brazil, it stands out as the eighth-highest cause of mortality among chronic or recurrent infections and has the highest mortality rate among systemic mycoses. Oral mucosal lesions may be the first visible physical manifestation of the disease. This study traced the epidemiological and clinical profiles of patients with oral lesions treated at the University Hospital Cassiano Antonio Moraes, Federal University of Espirito Santo...
November 16, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29147867/population-structure-of-candida-parapsilosis-no-genetic-difference-between-french-and-urugayan-isolates-using-microsatellite-length-polymorphism
#16
Marie Desnos-Ollivier, Victoria Bórmida, Philippe Poirier, Céline Nourrisson, Dinorah Pan, Stéphane Bretagne, Andrès Puime, Françoise Dromer
Candida parapsilosis is a human commensal yeast, frequently involved in infection worldwide and especially in neonates. It is the second species responsible for bloodstream infections in Uruguay and the third species in France. We were interested in knowing whether the population structure of isolates responsible for candidemia in France and in Uruguay was different. Genotyping methods based on microsatellite length polymorphism (MLP) have been described and are especially used for investigation of local outbreaks...
November 16, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29141535/sln-and-nlc-encapsulating-antifungal-agents-skin-drug-delivery-and-their-unexplored-potential-for-treating-onychomycosis
#17
Tais Gratieri, Anna Paula Krawczyk-Santos, Priscila Bianca Rodrigues da Rocha, Marcilio Cunha-Filho, Guilherme Martins Gelfuso, Ricardo Neves Marreto, Stephania Fleury Taveira
BACKGROUND: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. METHODS: We therefore compare skin and nail physiopathological structure and discuss the potential use of lipid nanoparticles in managing skin and nail mycoses, highlighting their unexplored use in onychomycosis...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29128761/inborn-errors-of-immunity-underlying-fungal-diseases-in-otherwise-healthy-individuals
#18
REVIEW
Juan Li, Donald C Vinh, Jean-Laurent Casanova, Anne Puel
It has been estimated that there are at least 1.5 million fungal species, mostly present in the environment, but only a few of these fungi cause human disease. Most fungal diseases are self-healing and benign, but some are chronic or life-threatening. Acquired and inherited defects of immunity, including breaches of mucocutaneous barriers and circulating leukocyte deficiencies, account for most severe modern-day mycoses. Other types of infection typically accompany these fungal infections. More rarely, severe fungal diseases can strike otherwise healthy individuals...
November 9, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29114929/disfiguring-facial-mycoses-a-diagnostic-and-therapeutic-challenge
#19
G H D C Janappriya, C N Gunasekera, B S D N Keragala, B S Dissanayake, P D Liyanagama, V Shanmuhathas, B Thanushah, L S M Sigera, P I Jayasekera
Some fungal infections may lead to devastating destruction of face, sometimes followed by fatal consequences. Conidiobolus coronatus is a rare, but serious emerging fungal pathogen of humans, causing Conidiobolomycosis, commonly infecting nasal mucosa and with potential to extend to involve vital structures such as brain and eyes. Treatment of this infection is extremely difficult and can cause significant disfiguring sequale, unless aggressively treated. We illustrate an interesting case, encountered within a short space of time affected by such infections and emphasize the need for thorough evaluation, investigation and aggressive initial treatment to achieve a good clinical response...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29112282/antifungals-discovery-an-insight-into-new-strategies-to-combat-antifungal-resistance
#20
REVIEW
Alexandre M Fuentefria, Bruna Pippi, Daiane F Dalla Lana, Katarzyna K Donato, Saulo F de Andrade
Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogs. Moreover, the treatment of mycoses has several limitations, such as; undesirable side effects, narrow activity spectrum, a small number of targets and fungal resistance; which are still of major concern in clinical practice...
November 7, 2017: Letters in Applied Microbiology
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