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https://www.readbyqxmd.com/read/27846662/-the-lymphoid-variant-of-hes-l-hes-as-differential-diagnose-of-severe-asthma-in-childhood
#1
T Leu, S Rauthe, C Wirth, H-U Simon, V Kunzmann, H Hebestreit, S Kunzmann
Based on a case report an overview on the differential diagnostic considerations with respect to blood hypereosinophilia (HE) and hypereosinophilic syndromes (HES) in childhood is given. A 13-year-old boy was admitted for the clarification of an asthma. In the blood count an increased HE with 3 500/µl (30%) was found along with elevated total serum IgE and IL-5 level (2 000 IU/ml and 17 pg/ml). Lung function showed an obstruction (FEV1 38%). Radiologically the picture of bronchiectasis and mucus pluggine appeared...
November 2016: Klinische Pädiatrie
https://www.readbyqxmd.com/read/27820955/antifungal-therapies-for-allergic-bronchopulmonary-aspergillosis-in-people-with-cystic-fibrosis
#2
REVIEW
Heather E Elphick, Kevin W Southern
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is an allergic reaction to colonisation of the lungs with the fungus Aspergillus fumigatus and affects around 10% of people with cystic fibrosis. ABPA is associated with an accelerated decline in lung function. High doses of corticosteroids are the main treatment for ABPA; although the long-term benefits are not clear, their many side effects are well-documented. A group of compounds, the azoles, have activity against Aspergillus fumigatus and have been proposed as an alternative treatment for ABPA...
November 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27814579/the-emergence-of-aspergillus-species-in-chronic-respiratory-disease
#3
Anthony Ca Yii, Mariko S Koh, Therese S Lapperre, Gan L Tan, Sanjay H Chotirmall
Chronic lung disease is recognized as an important risk factor for developing pulmonary aspergillosis. The development of specific aspergillus-associated syndromes depends on host immunity and underlying lung disease. In the setting of asthma, hypersensitivity to Aspergillus can lead to allergic bronchopulmonary aspergillosis (ABPA) or severe asthma with fungal sensitization (SAFS). Chronic use of systemic or inhaled corticosteroids coupled with recurrent antibiotic use for exacerbations prevalent in chronic obstructive pulmonary disease (COPD) predisposes to chronic pulmonary aspergillosis (CPA)...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27805757/the-relationship-between-biomarkers-of-fungal-allergy-and-lung-damage-in-asthma
#4
K F Woolnough, M Richardson, C Newby, M Craner, M Bourne, W Monteiro, S Siddiqui, P Bradding, C H Pashley, A J Wardlaw
BACKGROUND: Immunological biomarkers are the key to the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and fungal sensitisation, but how these relate to clinically relevant outcomes is unclear. OBJECTIVES: To assess how fungal immunological biomarkers are related to fixed airflow obstruction and radiological abnormalities in moderate to severe asthma. METHODS: Cross-sectional study of 431 asthmatics. Inflammatory biomarkers, lung function and an IgE fungal panel to colonising filamentous fungi, yeasts and fungal aeroallergens were measured...
November 2, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27794529/bronchiectasis-and-aspergillus-how-are-they-linked
#5
Anthony De Soyza, Stefano Aliberti
Bronchiectasis is a chronic airway infection syndrome, distinct from cystic fibrosis that is rising in prevalence and is associated with significant morbidity and mortality. It can be caused by many etiologies including post-infectious effects or be seen in common lung diseases such as chronic obstructive pulmonary disease (COPD) or severe asthma. Bronchiectasis is associated with many Aspergillus-associated syndromes: allergic bronchopulmonary aspergillosis (ABPA) may complicate asthma, thus leading to bronchiectasis as part of the diagnostic criteria of ABPA or can complicate preexisting bronchiectasis due to another etiology...
October 28, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27744712/developments-in-the-diagnosis-and-treatment-of-allergic-bronchopulmonary-aspergillosis
#6
Ritesh Agarwal, Inderpaul S Sehgal, Sahajal Dhooria, Ashutosh N Aggarwal
Allergic bronchopulmonary aspergillosis (ABPA) is a complex pulmonary disorder characterized by recurrent episodes of wheezing, fleeting pulmonary opacities and bronchiectasis. It is the most prevalent of the Aspergillus disorders with an estimated five million cases worldwide. Despite six decades of research, the pathogenesis, diagnosis and treatment of this condition remains controversial. The International Society for Human and Animal Mycology has formed a working group to resolve the controversies around this entity...
November 7, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27734646/cavitary-lung-lesions-in-a-difficult-to-treat-asthma-patient
#7
R Ragesh, Animesh Ray, Agrima Mian, Surabhi Vyas, S K Sharma
We describe an interesting case of severe asthma who was not showing satisfactory response to standard treatment. Investigations revealed him to be suffering from allergic bronchopulmonary aspergillosis (ABPA). After starting systemic steroids he showed marked improvement initially only to have recurrent symptoms within a year. He was investigated further and found to have chronic pulmonary aspergillosis in the form of chronic cavitary pulmonary aspergillosis (CCPA) and aspergilloma as also the presence of selective IgA deficiency...
April 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27717223/case-series-of-omalizumab-for-allergic-bronchopulmonary-aspergillosis-in-cystic-fibrosis-patients
#8
Raphaële Nové-Josserand, Soazic Grard, Lila Auzou, Philippe Reix, Marlène Murris-Espin, François Brémont, Benyebka Mammar, Laurent Mely, Dominique Hubert, Isabelle Durieu, Pierre-Régis Burgel
Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti-IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy...
October 7, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27708669/genetic-susceptibility-to-allergic-bronchopulmonary-aspergillosis-in-asthma-a-genetic-association-study
#9
Nicola L D Overton, David W Denning, Paul Bowyer, Angela Simpson
BACKGROUND: In patients with asthma, the fungus Aspergillus fumigatus can cause allergic bronchopulmonary aspergillosis (ABPA). Familial ABPA is reported, and some genetic factors have been associated with the disease, however, these are small studies (n ≤ 38) and do not explain all cases of ABPA. METHODS: We analysed SNPs in 95 ABPA patients, comparing frequencies to 152 atopic asthmatic and 279 healthy controls. Twenty two genes were selected from literature, and 195 tagging SNPs were analysed for genetic association with ABPA using logistic regression corrected for multiple testing...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27608478/clinical-and-radiological-signs-of-abpa-associated-with-airways-infection-with-aspergillus-in-the-absence-of-specific-ige
#10
F Sunzini, C Barbato, C Canofari, L Lugari, R Perricone, A Bergamini
Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus that mainly affects patients with asthma. For diagnosis, elevated serum IgE level are needed according to Greenberger and Patterson criteria. We report a case of 43 years-old woman who developed ABPA with productive cough, fever and radiological findings of multiple confluent areas of consolidation in both upper lobes. Laboratory tests showed elevated peripheral eosinophil counts (9.3 x 10(3)/ml). In bronchial washing A...
September 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27601608/are-allergic-fungal-rhinosinusitis-and-allergic-bronchopulmonary-aspergillosis-lifelong-conditions
#11
Ritesh Agarwal, Sandeep Bansal, Arunaloke Chakrabarti
Aspergillus fumigatus can cause several allergic disorders including Aspergillus-sensitized asthma, allergic bronchopulmonary aspergillosis (ABPA), and allergic fungal rhinosinusitis (AFRS). ABPA is an immunological pulmonary disorder caused by allergic reactions mounted against antigens of A. fumigatus colonizing the airways of patients with asthma (and cystic fibrosis). Allergic bronchopulmonary mycosis is an allergic fungal airway disease caused by thermotolerant fungi other than A. fumigatus On the other hand, AFRS is a type of chronic rhinosinusitis that is also a result of hypersensitivity reactions to the presence of fungi that become resident in the sinuses...
September 6, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27585455/allergic-bronchopulmonary-aspergillosis-alla-radiologist-needs-to-know
#12
REVIEW
Mandeep Kumar Garg, Madhurima Sharma, Ritesh Agarwal, Ashutosh N Aggarwal, Pankaj Gupta, Kushaljit Singh Sodhi, Arunaloke Chakrabarty, Niranjan Khandelwal
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is an immunological lung disorder occurring due to hypersensitivity to fungus Aspergillus fumigatus. Early diagnosis of ABPA is desirable as the disease can cause irreversible damage and end stage lung disease. Diagnosis of ABPA is based upon a set of clinical, serological and radiological criteria. Radiology plays an important role in the diagnosis of ABPA. However a radiologist should also be familiar with various clinical and serological criteria, so as to have a complete understanding of the disease process and to give a confident diagnosis...
2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27542151/aspergillus-fumigatus-components-distinguish-ige-but-not-igg4-profiles-between-fungal-sensitization-and-allergic-broncho-pulmonary-aspergillosis
#13
J Vitte, T Romain, A Carsin, M Gouitaa, N Stremler-Le Bel, M Baravalle-Einaudi, I Cleach, M Reynaud-Gaubert, J-C Dubus, J-L Mège
Aspergillus fumigatus is the causative agent of allergic broncho-pulmonary aspergillosis. Prompt and accurate diagnosis may be difficult to achieve with current clinical and laboratory scores, which do not include immune responses to recombinant A. fumigatus allergens. We measured specific immunoglobulin E and G4 directed to recombinant A. fumigatus allergens in 55 cystic fibrosis patients without allergic broncho-pulmonary aspergillosis but sensitized to A. fumigatus and in nine patients with allergic broncho-pulmonary aspergillosis (two with cystic fibrosis and seven with asthma)...
November 2016: Allergy
https://www.readbyqxmd.com/read/27524978/direct-molecular-diagnosis-of-aspergillosis-and-cyp51a-profiling-from-respiratory-samples-of-french-patients
#14
Yanan Zhao, Cécile Garnaud, Marie-Pierre Brenier-Pinchart, Anne Thiébaut-Bertrand, Christel Saint-Raymond, Boubou Camara, Rebecca Hamidfar, Odile Cognet, Danièle Maubon, Muriel Cornet, David S Perlin
BACKGROUND: Microbiological diagnosis of aspergillosis and triazole resistance is limited by poor culture yield. To better estimate this shortcoming, we compared culture and molecular detection of A. fumigatus in respiratory samples from French patients at risk for aspergillosis. METHODS: A total of 97 respiratory samples including bronchoalveolar lavages (BAL), bronchial aspirates (BA), tracheal aspirates, sputa, pleural fluids, and lung biopsy were collected from 33 patients having invasive aspergillosis (n = 12), chronic pulmonary aspergillosis (n = 3), allergic bronchopulmonary aspergillosis (n = 7), or colonization (n = 11) and 28 controls...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27523578/role-of-aspergillus-fumigatus-specific-igg-in-diagnosis-and-monitoring-treatment-response-in-allergic-bronchopulmonary-aspergillosis
#15
Ritesh Agarwal, Devika Dua, Hansraj Choudhary, Ashutosh N Aggarwal, Inderpaul S Sehgal, Sahajal Dhooria, Mandeep Garg, Digambar Behera, Arunaloke Chakrabarti
Few studies have evaluated the utility of Aspergillus fumigatus-specific IgG in allergic bronchopulmonary aspergillosis (ABPA). Herein, we evaluate the role of specific IgG in diagnosis and monitoring treatment response in ABPA. Forty-eight control subjects with A. fumigatus-associated asthma underwent A. fumigatus-specific IgG measurements at baseline, while specific IgG was assayed in 102 treatment-naïve subjects of ABPA at baseline, after eight weeks of glucocorticoid therapy, and during exacerbations...
January 2017: Mycoses
https://www.readbyqxmd.com/read/27492581/a-distinct-sortase-srtb-anchors-and-processes-a-streptococcal-adhesin-abpa-with-a-novel-structural-property
#16
Xiaobo Liang, Bing Liu, Fan Zhu, Frank A Scannapieco, Elaine M Haase, Steve Matthews, Hui Wu
Surface display of proteins by sortases in Gram-positive bacteria is crucial for bacterial fitness and virulence. We found a unique gene locus encoding an amylase-binding adhesin AbpA and a sortase B in oral streptococci. AbpA possesses a new distinct C-terminal cell wall sorting signal. We demonstrated that this C-terminal motif is required for anchoring AbpA to cell wall. In vitro and in vivo studies revealed that SrtB has dual functions, anchoring AbpA to the cell wall and processing AbpA into a ladder profile...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27489792/delayed-diagnosis-of-allergic-bronchopulmonary-aspergillosis-due-to-absence-of-asthmatic-symptoms
#17
Young Kim, Hong-Yeul Lee, Kang-Mo Gu, Joo-Young Lee, Sang-Won Yoon, Tae-Yeon Park, Jae-Chol Choi, Jae-Yeol Kim, In-Won Park, Jong-Wook Shin, Byoung-Whui Choi, Jae-Woo Jung
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease with small prevalence. Exposure to aspergillus mold causes immunologic hypersensitivity and may cause ranges of symptoms from minimal to detrimental outcomes. Diagnosing and treating the disease before the development of bronchiectasis may save the patient from poor outcomes. This report presents a case of recurrent ABPA without any symptom of asthma, which impeded the correct diagnosis even after numerous hospitalizations.
July 2016: Asia Pacific Allergy
https://www.readbyqxmd.com/read/27453814/allergic-bronchopulmonary-aspergillosis-masquerading-as-recurrent-bacterial-pneumonia
#18
Vu Le Thuong, Lam Nguyen Ho, Ngoc Tran Van
Allergic Bronchopulmonary Aspergillosis (ABPA) can be diagnosed in an asthmatic with suitable radiologic and immunological features. However ABPA is likely to be misdiagnosed with bacterial pneumonia. Here we report a case of ABPA masquerading as recurrent bacterial pneumonia. Treatment with high-dose inhaled corticosteroids was effective. To our best knowledge, this is the first reported case of ABPA in Vietnam.
June 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27419184/human-immunodeficiency-virus-and-allergic-bronchopulmonary-aspergillosis-case-report-and-review-of-literature
#19
Panagis Galiatsatos, Michael T Melia, Leann L Silhan
Allergic bronchopulmonary aspergillosis (ABPA) results from a hypersensitivity response to airways colonization with Aspergillus fumigatus, and it occurs most often in individuals with asthma or cystic fibrosis. Allergic bronchopulmonary aspergillosis is an indolent, but potentially progressive, disease in patients. In patients infected with human immunodeficiency virus (HIV), ABPA is rare, and its description in the literature is limited to case reports. We describe the occurrence of ABPA in a 37-year-old woman with well controlled HIV infection...
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27374215/concurrent-sensitization-to-aspergillus-fumigatus-in-tropical-pulmonary-eosinophilia
#20
Sunil K Chhabra, Devi Jyoti Dash
Tropical pulmonary eosinophilia (TPE) is characterized by lung tissue and peripheral blood eosinophilia. Serum total IgE is also markedly increased in TPE. However, an association with asthma or other hypersensitivity conditions has not been described. During the diagnostic workup of three patients eventually confirmed to have TPE, hypersensitivity to the fungus, Aspergillus Fumigatus was found. However, there was no evidence of diseases of aspergillus hypersensitivity such as severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA)...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
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