keyword
https://read.qxmd.com/read/38546237/should-atelectasis-be-considered-a-pulmonary-complication-and-indicator-of-poor-prognosis-in-cystic-fibrosis
#1
JOURNAL ARTICLE
María Martínez Redondo, Carlos Carpio Segura, Ester Zamarrón De Lucas, Rodolfo Álvarez-Sala Walther, Concepción Prados Sánchez
OBJECTIVE: This study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF. METHODS: This multicenter, case-control, observational, retrospective study included two groups of patients with CF: a case group (patients with persistent atelectasis who were followed-up at least for 2 years) and a control group (patients without atelectasis matched 1:1 by sex and age [±3 years])...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38520686/bronchiectasis-severity-index-and-faced-scores-in-patients-with-allergic-bronchopulmonary-aspergillosis-complicating-asthma-do-they-correlate-with-immunological-severity-or-high-attenuation-mucus
#2
JOURNAL ARTICLE
Shruti Phadnis, Valliappan Muthu, Inderpaul S Sehgal, Kuruswamy T Prasad, Sahajal Dhooria, Ashutosh N Aggarwal, Ritesh Agarwal
Background: The utility of two disease-severity indices, namely bronchiectasis severity index (BSI) and FACED score in allergic bronchopulmonary aspergillosis (ABPA) remains unknown. Objective: To correlate the BSI and FACED scores with immunological parameters (serum IgE [total and A. fumigatus -specific], A. fumigatus -specific IgG, blood eosinophil count), and high-attenuation mucus on chest computed tomography in ABPA. The secondary objectives were to evaluate the correlation between BSI and FACED scores and correlate the BSI/FACED scores with the bronchiectasis health questionnaire (BHQ) and Saint George's Respiratory Questionnaire (SGRQ)...
March 23, 2024: Journal of Asthma
https://read.qxmd.com/read/38514095/th2-skewed-peripheral-t-helper-cells-drives-b-cells-in-allergic-bronchopulmonary-aspergillosis
#3
JOURNAL ARTICLE
Rong-Guang Luo, Yi-Fan Wu, Hai-Wen Lu, Dong Weng, Jia-Yan Xu, Le-Le Wang, Li-Sha Zhang, Cai-Qi Zhao, Jian-Xiong Li, Yong Yu, Xin-Ming Jia, Jin-Fu Xu
INTRODUCTION: Patients with allergic bronchopulmonary aspergillosis (ABPA) suffer from repeated exacerbations. However, the involvement of T cell subsets remains unclear. METHODS: We enrolled ABPA patients, asthma patients and healthy controls. Th1, Th2, Th17, Treg and IL-21+ CD4+ T cells in total or sorted subsets of peripheral blood mononuclear cells (PBMCs) and ABPA Bronchoalveolar Lavage fluid (BALF) were analyzed by flow cytometry. RNA sequencing of subsets of CD4+ T cells were done in exacerbated ABPA patients and healthy controls...
March 21, 2024: European Respiratory Journal
https://read.qxmd.com/read/38508949/ecfs-standards-of-care-on-cftr-related-disorders-identification-and-care-of-the-disorders
#4
JOURNAL ARTICLE
N J Simmonds, K W Southern, E De Wachter, K De Boeck, F Bodewes, J G Mainz, P G Middleton, C Schwarz, V Vloeberghs, M Wilschanski, E Bourrat, J D Chalmers, C Y Ooi, D Debray, D G Downey, P Eschenhagen, E Girodon, G Hickman, A Koitschev, D Nazareth, J A Nick, D Peckham, D VanDevanter, C Raynal, I Scheers, M D Waller, I Sermet-Gaudelus, C Castellani
This is the third paper in the series providing updated information and recommendations for people with cystic fibrosis transmembrane conductance regulator (CFTR)-related disorder (CFTR-RD). This paper covers the individual disorders, including the established conditions - congenital absence of the vas deferens (CAVD), diffuse bronchiectasis and chronic or acute recurrent pancreatitis - and also other conditions which might be considered a CFTR-RD, including allergic bronchopulmonary aspergillosis, chronic rhinosinusitis, primary sclerosing cholangitis and aquagenic wrinkling...
March 19, 2024: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://read.qxmd.com/read/38423624/revised-clinical-practice-guidelines-for-diagnosing-classifying-and-treating-allergic-bronchopulmonary-aspergillosis-mycoses-a-delphi-statement-from-the-isham-abpa-working-group
#5
JOURNAL ARTICLE
Ritesh Agarwal, Inderpaul Singh Sehgal, Valliappan Muthu, David W Denning, Arunaloke Chakrabarti, Kathirvel Soundappan, Mandeep Garg, Shivaprakash M Rudramurthy, Sahajal Dhooria, Darius Armstrong-James, Koichiro Asano, Jean-Pierre Gangneux, Sanjay H Chotirmall, Helmut J F Salzer, James D Chalmers, Cendrine Godet, Marcus Joest, Iain Page, Parameswaran Nair, P Arjun, Raja Dhar, Kana Ram Jat, Geethu Joe, Uma Maheswari Krishnaswamy, Joseph L Mathew, Venkata Nagarjuna Maturu, Anant Mohan, Alok Nath, Dharmesh Patel, Jayanthi Savio, Puneet Saxena, Rajeev Soman, Balamugesh Thangakunam, Caroline G Baxter, Felix Bongomin, William J Calhoun, Oliver A Cornely, Jo A Douglass, Chris Kosmidis, Jacques F Meis, Richard Moss, Alessandro C Pasqualotto, Danila Seidel, Rosanne Sprute, Kuruswamy Thurai Prasad, Ashutosh N Aggarwal
BACKGROUND: The ISHAM working group proposed recommendations for managing allergic bronchopulmonary aspergillosis (ABPA) nearly a decade ago. There is a need to update these recommendations due to advances in diagnostics and therapeutics. METHODS: An international expert group was convened to develop guidelines for managing ABPA (caused by Aspergillus spp.) and allergic bronchopulmonary mycosis (ABPM, fungi other than Aspergillus spp.) in adults and children using a modified Delphi method (two online rounds and one in-person meeting)...
February 29, 2024: European Respiratory Journal
https://read.qxmd.com/read/38417459/-allergic-bronchopullmonary-aspergillosis-abpa-an-update
#6
JOURNAL ARTICLE
Marcus Joest, Johanna Klein, Daniel Kütting, Dirk Skowasch
Allergic bronchopulmonary aspergillosis (ABPA) is a regular occurrence in everyday pneumology. ABPA should be considered in patients with severe asthma, in mould allergic patients with very high serum IgE levels and in patients with cystic fibrosis. The aim should be to make the diagnosis as early as possible in the course of the disease to avoid late complications such as bronchiectasis and fibrotic lung remodelling. Symptoms are highly variable and rather non-specific, overlapping with those of the underlying primary disease...
March 2024: Pneumologie
https://read.qxmd.com/read/38407762/polymorphisms-in-innate-and-adaptive-immune-genes-in-subjects-with-allergic-bronchopulmonary-aspergillosis-complicating-asthma
#7
JOURNAL ARTICLE
Rimjhim Kanaujia, Amit Arora, Arunaloke Chakrabarti, Shivaprakash M Rudramurthy, Ritesh Agarwal
Innate and adaptive immunity play a crucial role in allergic bronchopulmonary aspergillosis (ABPA) pathogenesis. We performed next-generation sequencing using the Illumina TruSight One panel (4,811 human disease-associated genes, at least 20 × coverage) and selected 22 known immune genes (toll-like receptors (TLRs), C-type lectin, interleukin-4 receptor, and others). We included ABPA (n = 18), asthma without ABPA (n = 12), and healthy controls (n = 8)...
February 26, 2024: Mycopathologia
https://read.qxmd.com/read/38387646/ct-imaging-assessment-of-response-to-treatment-in-allergic-bronchopulmonary-aspergillosis-in-adults-with-bronchial-asthma
#8
JOURNAL ARTICLE
Cendrine Godet, Anne-Laure Brun, Francis Couturaud, François Laurent, Jean-Pierre Frat, Sylvain Marchand-Adam, Frédéric Gagnadoux, Elodie Blanchard, Camille Taillé, Bruno Philippe, Sandrine Hirschi, Claire Andréjak, Arnaud Bourdin, Cécile Chenivesse, Stéphane Dominique, Gilles Mangiapan, Marlène Murris-Espin, Frédéric Rivière, Gilles Garcia, François-Xavier Blanc, François Goupil, Anne Bergeron, Thomas Flament, Pascaline Priou, Hervé Mal, Joe de Keizer, Stéphanie Ragot, Jacques Cadranel
BACKGROUND: One of the major challenges in managing allergic bronchopulmonary aspergillosis (ABPA) remains consistent and reproducible assessment of response to treatment. RESEARCH QUESTION: What are the most relevant changes in computed tomography (CT-scan) parameters over time for assessing response to treatment? STUDY DESIGN AND METHODS: In this ancillary study of a randomized clinical trial (NEBULAMB), asthmatic patients with available CT-scan and without exacerbation during a 4-month ABPA exacerbation treatment period (corticosteroids and itraconazole) were included...
February 20, 2024: Chest
https://read.qxmd.com/read/38369615/sensitivity-and-specificity-of-ldbio-aspergillus-ict-lateral-flow-assay-for-diagnosing-allergic-bronchopulmonary-aspergillosis-in-adult-asthmatics
#9
JOURNAL ARTICLE
Inderpaul Singh Sehgal, Valliappan Muthu, Sahajal Dhooria, Kuruswamy Thurai Prasad, Shivaprakash M Rudramurthy, Ashutosh Nath Aggarwal, Mandeep Garg, Jean-Pierre Gangneux, Arunaloke Chakrabarti, Ritesh Agarwal
BACKGROUND: Aspergillus fumigatus-specific IgG estimation is crucial for diagnosing allergic bronchopulmonary aspergillosis (ABPA). A point-of-care LDBio immunochromatographic lateral flow assay (LFA) had 0%-90% sensitivity to detect IgG/IgM antibodies against A. fumigatus. OBJECTIVE: To assess the accuracy of LDBio-LFA in diagnosing ABPA, using the modified ISHAM-ABPA working group criteria as the reference standard. The secondary objective was to compare the diagnostic performance between LDBio-LFA and A...
February 2024: Mycoses
https://read.qxmd.com/read/38350129/case-report-allergic-bronchopulmonary-aspergillosis-and-tropical-pulmonary-eosinophilia-co-occurrence-masquerading-as-refractory-allergic-bronchopulmonary-aspergillosis
#10
Manish Singh, Deepu K Peter, Simple Gupta, Vandana Rani V, Shalendra Singh
Pulmonary infiltrates with eosinophilia are a heterogeneous group of disorders that are characterized by pulmonary infiltrates on chest radiograph and elevated levels of eosinophils in the peripheral blood. Among patients with these disorders, reports of either allergic bronchopulmonary aspergillosis (ABPA) or tropical pulmonary eosinophilia (TPE) are common. However, the simultaneous occurrence of ABPA and TPE is not often reported. We present the case of a young man with a history of asthma who was diagnosed with ABPA and TPE...
February 13, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38295145/epidemiology-of-the-relationship-between-allergic-bronchopulmonary-aspergillosis-and-asthma
#11
JOURNAL ARTICLE
Matteo Maule, Joana Vitte, Francesca Ambrosani, Marco Caminati
PURPOSE OF REVIEW: Allergic bronchopulmonary aspergillosis (ABPA) can complicate the natural history of asthmatic patients, especially the more severe ones, worsening disease control and increasing the need for therapies, steroids in particular, and medical care. The aim of the present review is to summarize the latest epidemiological data related to the relationship between asthma and ABPA and to offer a summary of the most recent strategies that could potentially facilitate in the identification of ABPA in asthmatic patients...
January 31, 2024: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/38294679/near-fatal-asthma-in-a-case-of-allergic-bronchopulmonary-aspergillosis-abpa-treated-with-ecmo
#12
JOURNAL ARTICLE
Shili Zhong, Zhengbin Wu, Chunyan Chen, Hong Xiao, Zhen Wang
BACKGROUND: Fatal asthma is a rapidly progressing and highly fatal form of asthma. Mechanical ventilation, although necessary for respiratory support, can exacerbate the condition and lead to ventilator-associated lung injury. ECMO therapy is crucial in allowing the lungs to rest and recover, as it provides extracorporeal membrane oxygenation. CASE PRESENTATION: A 40-year-old man presented with dyspnea following a mountain climb, which rapidly worsened, leading to respiratory failure and loss of consciousness...
January 31, 2024: Journal of Asthma
https://read.qxmd.com/read/38282191/clinical-characteristics-of-allergic-bronchopulmonary-mycosis-caused-by-schizophyllum-commune
#13
JOURNAL ARTICLE
Tsuyoshi Oguma, Takashi Ishiguro, Katsuhiko Kamei, Jun Tanaka, Junko Suzuki, Akira Hebisawa, Yasushi Obase, Hiroshi Mukae, Takae Tanosaki, Shiho Furusho, Koji Kurokawa, Kentaro Watai, Hiroto Matsuse, Norihiro Harada, Ai Nakamura, Takuo Shibayama, Rie Baba, Kentaro Fukunaga, Hisako Matsumoto, Hisano Ohba, Susumu Sakamoto, Shinko Suzuki, Shintetsu Tanaka, Takahiro Yamada, Akira Yamasaki, Yuma Fukutomi, Yoshiki Shiraishi, Takahito Toyotome, Koichi Fukunaga, Terufumi Shimoda, Satoshi Konno, Masami Taniguchi, Katsuyoshi Tomomatsu, Naoki Okada, Koichiro Asano
BACKGROUND: Allergic bronchopulmonary mycosis (ABPM) is an allergic disease caused by type I and type III hypersensitivity to environmental fungi. Schizophyllum commune, a basidiomycete fungus, is one of the most common fungi that causes non-Aspergillus ABPM. OBJECTIVE: Herein, we attempted to clarify the clinical characteristics of ABPM caused by S. commune (ABPM-Sc) compared with those of allergic bronchopulmonary aspergillosis (ABPA). METHODS: Patients with ABPM-Sc or ABPA were recruited from a nationwide survey in Japan, a multicenter cohort, and a fungal database at the Medical Mycology Research Center of Chiba University...
January 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38240869/efficacy-of-omalizumab-in-adult-patients-with-allergic-bronchopulmonary-aspergillosis-a-multicentre-study-in-china
#14
JOURNAL ARTICLE
Peixv Chen, Yali Yu, Li He, Chunyi Zhang, Yiting Li, Di Wu, Ying Chen, Ran Wang, Guopeng Xu, Chao Cao
Despite conventional glucocorticoid and antifungal therapy, acute exacerbation and hospitalization occur frequently in patients with allergic bronchopulmonary aspergillosis (ABPA). Whether omalizumab is an effective and safe treatment for adult patients with ABPA complicating asthma. Patients with ABPA complicating asthma who were treated with omalizumab from October 2019 to May 2023 were collected from five tertiary hospitals and evaluated. The frequencies of acute exacerbation and hospitalization; the number of eosinophils; the total IgE levels; and the average monthly medical dosages after 3, 6, and 12 months of omalizumab treatment were analysed, and the data before and after treatment (up to one year) were compared...
January 19, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38232815/corticosteroid-sparing-effect-of-biologics-in-patients-with-allergic-bronchopulmonary-aspergillosis
#15
JOURNAL ARTICLE
Keara Darragh, Praveen Akuthota
No abstract text is available yet for this article.
January 15, 2024: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/38214461/abpa-and-afrs-addressing-prevalence-early-diagnosis-allergens-and-occupational-concerns
#16
REVIEW
Anu Priya Minhas, Santasabuj Das
ObjectiveThis study aimed to comprehensively investigate the prevalence of ABPA and AFRS, scrutinize existing diagnostic criteria and immunoassays, pinpoint their limitations, highlight ABPA as an occupational health implication, and identify suggestive measures to improve ABPA diagnosis in the context of Occupational Health Nursing and primary healthcare.Data SourcesThe data sources such as PubMed, Health and Safety Science Abstracts, OSH Update, Medline, and Google Scholar were searched.Study SelectionsAll published studies in the English language from 1990 till Oct, 2023 using Mesh terms keywords "Allergic bronchopulmonary aspergillosis", "Allergic fungal rhinosinusitis", "Signs and Symptoms", "Rapid Diagnostic Tests", "Diagnosis", "Occupational Health", "Occupational Health Nursing", "Prevalence", "Allergens" following "Boolean operators" search strategy were selected...
January 12, 2024: Journal of Asthma
https://read.qxmd.com/read/38196063/antifungal-resistance-in-pulmonary-aspergillosis
#17
JOURNAL ARTICLE
Paul E Verweij, Yinggai Song, Jochem B Buil, Jianhua Zhang, Willem J G Melchers
Aspergilli may cause various pulmonary diseases in humans, including allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), and acute invasive pulmonary aspergillosis (IPA). In addition, chronic colonization may occur in cystic fibrosis (CF). Aspergillus fumigatus represents the main pathogen, which may employ different morphotypes, for example, conidia, hyphal growth, and asexual sporulation, in the various Aspergillus diseases. These morphotypes determine the ease by which A...
January 9, 2024: Seminars in Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38192543/successful-treatment-with-dupilumab-in-mepolizumab-resistant-allergic-bronchopulmonary-aspergillosis
#18
Yasutaka Kawasaki, Kazuaki Nishiki, Takeshi Ishizaki
A 67-year-old woman with a history of poorly controlled asthma was admitted to our hospital with a persistent cough and abnormal chest radiographic findings. Her diagnosis was allergic bronchopulmonary aspergillosis (ABPA). Following treatment with mepolizumab, her symptoms and imaging findings improved initially. However, after approximately 2 years, the patient experienced a recurrent cough with elevated non-specific immunoglobulin E levels and worsening chest imaging findings, thereby changing her diagnosis to recurrent ABPA...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38186818/subacute-invasive-pulmonary-aspergillosis-in-a-nondiabetic-immunocompetent-female-suffering-from-allergic-broncho-pulmonary-aspergillosis
#19
Subodh Kumar, Devesh Pratap Singh, Sana Ansari, Vivek Hada
A 55-year-old female presented with recent exacerbation of the chronic cough, dyspnea, and copious expectoration. The symptoms worsened during the winter months. In the past, she was misdiagnosed with pulmonary tuberculosis. A computed tomography scan revealed bronchiectasis changes, high attenuated mucus, and hypereosinophilia. The diagnosis of Allergic Bronchopulmonary Aspergillosis (ABPA) with subacute invasion was confirmed through bronchoscopy and fungal culture. Treatment with oral voriconazole significantly improved lung function and quality of life...
November 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38154470/clinical-manifestation-and-treatment-of-allergic-bronchopulmonary-aspergillosis
#20
JOURNAL ARTICLE
Ritesh Agarwal, Valliappan Muthu, Inderpaul S Sehgal
Allergic bronchopulmonary aspergillosis (ABPA) is a complex hypersensitivity reaction to airway colonization by Aspergillus fumigatus in patients with asthma and cystic fibrosis. The pathophysiology of ABPA involves a complex interplay between the fungus and the host immune response, which causes persistent inflammation and tissue damage. Patients present with chronic cough, wheezing, and dyspnea due to uncontrolled asthma. Characteristic symptoms include the expectoration of brownish mucus plugs. Radiographic findings often reveal fleeting pulmonary infiltrates, bronchiectasis, and mucus impaction...
December 28, 2023: Seminars in Respiratory and Critical Care Medicine
keyword
keyword
57068
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.