keyword
https://read.qxmd.com/read/38400747/therapeutic-drug-monitoring-in-pregnancy-levetiracetam
#21
JOURNAL ARTICLE
Noam Fallik, Ilia Trakhtenbroit, Firas Fahoum, Lilach Goldstein
OBJECTIVE: Levetiracetam (LEV) is an antiseizure medication that is mainly excreted by the kidneys. Due to its low teratogenic risk, LEV is frequently prescribed for women with epilepsy (WWE). Physiological changes during gestation affect the pharmacokinetic characteristics of LEV. The goal of our study was to characterize the changes in LEV clearance during pregnancy and the postpartum period, to better plan an LEV dosing paradigm for pregnant women. METHODS: This retrospective observational study incorporated a cohort of women who were followed up at the epilepsy in pregnancy clinic at Tel Aviv Sourasky Medical Center during the years 2020-2023...
February 24, 2024: Epilepsia
https://read.qxmd.com/read/38373491/-indirects-causes-of-maternal-deaths-except-stroke-cardiovascular-diseases-and-infections-in-france-2016-2018
#22
JOURNAL ARTICLE
Véronique Le Guern, Mathias Rossignol, Jacques Lepercq
Maternal deaths from indirect obstetric causes result from a pre-existing condition or a condition that occurred during pregnancy without obstetric causes but was aggravated by the physiological effects of pregnancy. Twenty-nine deaths with an indirect cause related to a pre-existing condition, excluding circulatory diseases or infections, were analysed by the expert committee. Pre-pregnancy pathology was documented in 16 women (epilepsy, n=7; amyloid angiopathy, n=1; Dandy Walker syndrome, n=1; autoimmune diseases, n=3; diffuse infiltrative pneumonitis, n=1; thrombotic thrombocytopenic purpura, n=1; ovarian cancer in fragile X, n=1; major sickle cell disease, n=1)...
February 17, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
https://read.qxmd.com/read/38366344/dose-monitoring-of-lamotriginxe-monotherapy-in-pregnancy-are-pregnant-women-with-epilepsy-currently-optimally-managed-a-systematic-review
#23
JOURNAL ARTICLE
Yeonkyung Goo, Anne Marijn der Nederlanden, Andrew Bleasel, Jan-Willem Alffenaar, Hannah Yejin Kim
BACKGROUND: Lamotrigine monotherapy is the first-line treatment for epilepsy in pregnant women. However, altered pharmacokinetics during pregnancy can lead to suboptimal drug levels and increased seizure risk. This systematic review aimed to evaluate current therapeutic drug monitoring (TDM) strategies for lamotrigine monotherapy in pregnant women with epilepsy and provide guidance for monitoring and dose adjustments. METHODS: A systematic search was performed using the Ovid-MEDLINE, Ovid-EMBASE, and Ovid-Cochrane Central Register of Controlled Trials databases...
February 16, 2024: Therapeutic Drug Monitoring
https://read.qxmd.com/read/38352135/the-science-of-uncertainty-guides-fetal-neonatal-neurology-principles-and-practice-diagnostic-prognostic-opportunities-and-challenges
#24
REVIEW
Mark Steven Scher
Fetal-neonatal neurologists (FNNs) consider diagnostic, therapeutic, and prognostic decisions strengthened by interdisciplinary collaborations. Bio-social perspectives of the woman's health influence evaluations of maternal-placental-fetal (MPF) triad, neonate, and child. A dual cognitive process integrates "fast thinking-slow thinking" to reach shared decisions that minimize bias and maintain trust. Assessing the science of uncertainty with uncertainties in science improves diagnostic choices across the developmental-aging continuum...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38340680/the-teratogenesis-risk-associated-with-antiseizure-medication-duotherapy-in-women-with-epilepsy
#25
JOURNAL ARTICLE
Frank J E Vajda, Terence J O'Brien, Janet E Graham, Alison A Hitchcock, Piero Perucca, Cecilie M Lander, Mervyn J Eadie
PURPOSE: To investigate rates of occurrence of pregnancies associated with a foetal malformation (FM pregnancy rates) following simultaneous intrauterine exposure to two antiseizure medications in 524 pregnancies in women with epilepsy from the Australian Pregnancy Register who were treated simultaneously with various combinations and dosages of two antiseizure medications (duotherapy). RESULTS: FM pregnancy rates tended to be higher in those exposed simultaneously to two antiseizure medications, each of which was a statistically significant teratogen (valproate, topiramate, or carbamazepine), than when there was exposure to only one such teratogen...
February 2024: Epilepsy Research
https://read.qxmd.com/read/38340294/pregnancy-related-knowledge-in-women-with-epilepsy-in-childbearing-age-a-pilot-questionnaire-survey-from-china
#26
JOURNAL ARTICLE
Qiwei Li, Yina Cao, Jingxin Zhang, Yanlu Fu, Beibei Shen, Shuang Wang, Jiajia Fang
PURPOSE: We aim to understand the knowledge of and attitudes toward pregnancy issues among women with epilepsy (WWE) and their caregivers and analyze the answers from the questionnaire to expose topics that require educational activities; thus, WWE experiences pregnancy better. METHODS: WWE at their childbearing age and/or their caregivers who entered the Fourth Affiliated Hospital of Zhejiang University for treatment of their condition were invited to fill out a questionnaire between March 1 and November 31, 2022...
February 2024: Brain and Behavior
https://read.qxmd.com/read/38335875/clinical-characteristics-seizure-control-and-delivery-outcomes-in-pregnant-women-with-focal-and-generalized-epilepsies
#27
JOURNAL ARTICLE
Melikova Shahla, Mammadbayli Aytan
OBJECTIVE: To prospectively investigate the course of epilepsy and assess seizure control during pregnancy in women with focal epilepsy (FE) compared with generalized epilepsy (GE), to ascertain the effects of epilepsy and its types on delivery and neonatal outcomes, and to compare adverse outcomes between pregnancies complicated by epilepsy and normal pregnancies. METHODS: 124 pregnant women with epilepsy (WWE) were enrolled in a prospective study. Obstetric and neonatal outcomes were compared with those of 277 healthy women in the control group...
January 26, 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38308208/neurodevelopmental-outcomes-after-prenatal-exposure-to-lamotrigine-monotherapy-in-women-with-epilepsy-a-systematic-review-and-meta-analysis
#28
JOURNAL ARTICLE
Audrey Peron, Cyndie Picot, Lucie Jurek, Mikaïl Nourredine, Emmanuelle Ripoche, Priscilla Ajiji, Michel Cucherat, Judith Cottin
BACKGROUND: Lamotrigine has become one of the most commonly prescribed antiseizure medications (ASM) in epileptic women during pregnancy and therefore requires regular updates regarding its safety. The aim of this study was to estimate the association between in utero exposure to lamotrigine monotherapy and the occurrence of neurodevelopmental outcomes. METHODS: All comparative studies assessing the occurrence of neurodevelopmental outcomes after epilepsy-indicated lamotrigine monotherapy exposure during pregnancy were searched...
February 2, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38305480/outcomes-following-exposure-to-lacosamide-monotherapy-during-pregnancy-and-breastfeeding-a-prospective-case-series
#29
JOURNAL ARTICLE
Magdalena Bosak, Radosław Dziedzic, Katarzyna Matwiej, Agnieszka Słowik
AIM OF THE STUDY: To evaluate the safety of lacosamide (LCM) monotherapy during pregnancy and breastfeeding. MATERIAL AND METHODS: Patients taking LCM monotherapy treated at the university epilepsy clinic were prospectively followed up during pregnancy, delivery, and breastfeeding. Data on seizure frequency, LCM dosage, pregnancy course, delivery and breastfeeding, birth outcome, congenital malformation, and development of newborns was collected. RESULTS: Four pregnancies in three patients with refractory focal epilepsy treated with LCM monotherapy were reported...
February 2, 2024: Neurologia i Neurochirurgia Polska
https://read.qxmd.com/read/38304661/navigating-the-complexity-of-a-bipolar-pregnant-patient-with-multiple-comorbidities
#30
Paula Traugott, Adriana Medina, Jonathan M Parker
Bipolar disorder I (BDI) is a psychiatric disorder characterized by the occurrence of at least one manic episode. Within the scope of neurological disorders, epilepsy and psychogenic nonepileptic seizures (PNES) share clinical features and can be differentiated using electroencephalogram (EEG). Substance use disorder is a condition defined by impaired control, risky use, social impairment, and addictive behaviors. We present the case of a 20-year-old pregnant woman with BDI associated with a history of epilepsy, PNES, and polyvalent substance use...
January 2024: Curēus
https://read.qxmd.com/read/38294338/topiramate-ban-in-women-of-childbearing-potential-with-idiopathic-generalized-epilepsy-does-effectiveness-offset-the-teratogenic-risks
#31
JOURNAL ARTICLE
Emanuele Cerulli Irelli, Enrico Cocchi, Barbara Mostacci, Biagio Orlando, Joanna Gesche, Roberto H Caraballo, Simona Lattanzi, Gionata Strigaro, Cecilia Catania, Patrizia Pulitano, Chiara Panzini, Edoardo Ferlazzo, Angelo Pascarella, Sara Casciato, Chiara Pizzanelli, Loretta Giuliano, Veronica Viola, Francesco Fortunato, Giancarlo Di Gennaro, Antonio Gambardella, Angelo Labate, Francesca F Operto, Anna T Giallonardo, Betul Baykan, Christoph P Beier, Carlo Di Bonaventura
Regulatory agencies have recently discouraged the prescription of topiramate (TPM) to women of childbearing potential with epilepsy due to growing evidence of the teratogenic and neurodevelopmental risks associated with its use during pregnancy. It remains, however, unclear whether the use of TPM in this population can be supported to some extent by its high effectiveness. In this multicenter, retrospective, cohort study performed at 22 epilepsy centers, we investigated the comparative effectiveness of TPM and levetiracetam (LEV) given as first-line antiseizure medication in a cohort of women of childbearing potential with idiopathic generalized epilepsy (IGE)...
January 31, 2024: Epilepsia
https://read.qxmd.com/read/38277851/preferences-and-experiences-of-parents-guardians-of-youth-with-epilepsy-and-intellectual-disability-on-reproductive-health-counseling
#32
JOURNAL ARTICLE
Geetha Vasudevan, Robyn Filipink, Jenna Gaesser, Traci M Kazmerski, Yoshimi Sogawa, Laura Kirkpatrick
OBJECTIVE: To explore the experiences and preferences of parents/guardians of adolescents and young adults (AYA) of childbearing potential with co-occurring epilepsy and intellectual disability (ID) regarding counseling by neurologists on sexual and reproductive health (SRH) topics such as pregnancy, contraception, menstruation, and folic acid supplementation. METHODS: We conducted semi-structured interviews with parents/guardians of AYAs (12-28 years old) of childbearing potential with co-occurring epilepsy and ID, recruited from a tertiary-care children's hospital...
January 25, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38262329/real-world-practices-in-reproductive-health-and-counselling-for-women-with-epilepsy-a-canadian-perspective
#33
JOURNAL ARTICLE
Hayley F Thornton, Tadeu A Fantaneanu, Tinghua Zhang, Eduard Bercovici, Chantelle Hrazdil, Kristin M Ikeda, Janani Kassiri, Ana Suller Marti, Raluca Pana, Arezoo Rezazadeh, Eliane Kobayashi, Esther Bui
Canadian women of reproductive potential living with epilepsy present unique care challenges due to the complex interplay of hormones, seizures, and medications. This study explores reproductive health practices and counselling for women with epilepsy. Through a questionnaire developed by the Canadian League Against Epilepsy women with epilepsy (WWE) workgroup, we are the first to report demographic and real-world practice characteristics of Canadian healthcare professionals providing care for WWE with specific focus on family planning, birth plans, and postpartum care counselling...
January 22, 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38258470/genotype-phenotype-correlation-in-prader-willi-syndrome-a-large-sample-analysis-in-china
#34
JOURNAL ARTICLE
Shujiong Mao, Lili Yang, Ying Gao, Chaochun Zou
The genotype-phenotype relationship in PWS patients is important for a better understanding of the clinical phenotype and clinical characteristics of different genotypes of PWS in children. We aimed to explore the influence of specific gene changes on the clinical symptoms of PWS and the value of early screening and early intervention of the condition. All data in this study were extracted from the database of the XiaoPang Weili Rare Disease Care Center. The collected information included basic demographics, maternal pregnancy information, endocrine abnormalities, growth and development abnormalities, and other clinical phenotypes...
January 23, 2024: Clinical Genetics
https://read.qxmd.com/read/38255008/sodium-channel-gene-variants-in-fetuses-with-abnormal-sonographic-findings-expanding-the-prenatal-phenotypic-spectrum-of-sodium-channelopathies
#35
JOURNAL ARTICLE
Andrea Hadjipanteli, Athina Theodosiou, Ioannis Papaevripidou, Paola Evangelidou, Angelos Alexandrou, Nicole Salameh, Ioannis Kallikas, Kyriakos Kakoullis, Sofia Frakala, Christina Oxinou, Andreas Marnerides, Ludmila Kousoulidou, Violetta C Anastasiadou, Carolina Sismani
Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation of action potentials in the brain and muscle. Pathogenic variants in genes encoding VGSCs have been associated with severe disorders including epileptic encephalopathies and congenital myopathies. In this study, we identified pathogenic variants in genes encoding the α subunit of VGSCs in the fetuses of two unrelated families with the use of trio-based whole exome sequencing, as part of a larger cohort study. Sanger sequencing was performed for variant confirmation as well as parental phasing...
January 18, 2024: Genes
https://read.qxmd.com/read/38235017/association-of-oxcarbazepine-concentration-with-seizure-frequency-in-pregnant-women-with-epilepsy
#36
JOURNAL ARTICLE
Lin-Yan Wei, Zheng-Yan-Ran Xu, Zhen-Zhen Lai, Na Dong, Yi-Wen Sang, Yi Guo
The management of epilepsy during pregnancy presents particular challenges for neurologists worldwide. Currently, there are no clear recommendations for oxcarbazepine (OXC) specific target concentration during pregnancy. We conducted this retrospective observational cohort study on pregnant women with epilepsy (WWE) who received OXC monotherapy or polytherapy, at the epilepsy outpatient clinic of a tertiary hospital in eastern China. Sixteen pregnancies of 16 WWE were split into the seizure-free group or the non-seizure-free group, according to whether they had been seizure free for more than one year prior to conception or not...
2024: Epilepsy & behavior reports
https://read.qxmd.com/read/38233889/management-of-status-epilepticus-in-pregnancy-a-clinician-survey
#37
JOURNAL ARTICLE
Dionne Swor, Pallavi Juneja, Charlotte Constantine, Catrin Mann, Felix Rosenow, Suzette LaRoche
BACKGROUND: Status epilepticus in pregnancy (SEP) is rare and life-threatening for both mother and fetus. There are well-established guidelines for the management of women with epilepsy during pregnancy; however, there is little evidence guiding the management of SEP, leading to uncertainty among treating physicians. Therefore, this survey aims to investigate the real-world practices of physicians treating SEP to explore management approaches for improvements in care. METHODS: An anonymous, electronic survey was created and distributed to neurointensivists and neurologists between September and December 2021...
January 18, 2024: Neurological research and practice
https://read.qxmd.com/read/38232647/treatment-patterns-in-women-of-childbearing-age-and-pregnant-women-with-epilepsy-in-poland-between-the-years-2019-and-2022-a-nationwide-population-based-cohort-study
#38
JOURNAL ARTICLE
Katarzyna Wójcik, Marcin Kruk, Beata Koń, Agnieszka Słowik, Magdalena Bosak
AIM: To describe the antiseizure medications (ASMs) prescription pattern in women of childbearing age (WOCA) and pregnant women with epilepsy in the 2019-2022 period in Poland MATERIALS AND METHODS: The National Health Fund (NHF) databases were analyzed. Women aged 15-49 years were considered as being of childbearing age, while exposure during pregnancy was estimated taking into account 15 months before delivery. ASMs belonging to the N03A subgroup of the Anatomical Therapeutic Chemical Classification System, reimbursed by NHF were analyzed...
February 2024: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/38223363/issues-of-women-with-epilepsy-and-suitable-antiseizure-drugs
#39
REVIEW
Sang Kun Lee
Seizure aggravation in women with epilepsy (WWE) tends to occur at two specific times during the menstrual cycle: the perimenstrual phase and the ovulation period. Antiseizure drugs (ASDs), especially those that induce enzymes, can accelerate the metabolism of hormones in oral contraceptives, rendering them less effective. Estrogen in contraceptive pills increases the metabolism of lamotrigine. Physiological changes during pregnancy can significantly impact the pharmacokinetics of ASDs, potentially necessitating adjustments in dosage for women with epilepsy to maintain seizure control...
December 2023: Journal of Epilepsy Research
https://read.qxmd.com/read/38205522/the-causal-association-between-maternal-depression-anxiety-and-infection-in-pregnancy-and-neurodevelopmental-disorders-among-410-461-children-a-population-study-using-quasi-negative-control-cohorts-and-sibling-analysis
#40
JOURNAL ARTICLE
Holly Hope, Matthias Pierce, Hend Gabr, Maja R Radojčić, Eleanor Swift, Vicky P Taxiarchi, Kathryn M Abel
BACKGROUND: To address if the long-standing association between maternal infection, depression/anxiety in pregnancy, and offspring neurodevelopmental disorder (NDD) is causal, we conducted two negative-control studies. METHODS: Four primary care cohorts of UK children (pregnancy, 1 and 2 years prior to pregnancy, and siblings) born between 1 January 1990 and 31 December 2017 were constructed. NDD included autism/autism spectrum disorder, attention-deficit/hyperactivity disorder, intellectual disability, cerebral palsy, and epilepsy...
January 11, 2024: Psychological Medicine
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