Emanuele Cerulli Irelli, Enrico Cocchi, Barbara Mostacci, Biagio Orlando, Joanna Gesche, Roberto H Caraballo, Simona Lattanzi, Gionata Strigaro, Cecilia Catania, Patrizia Pulitano, Chiara Panzini, Edoardo Ferlazzo, Angelo Pascarella, Sara Casciato, Chiara Pizzanelli, Loretta Giuliano, Veronica Viola, Francesco Fortunato, Giancarlo Di Gennaro, Antonio Gambardella, Angelo Labate, Francesca F Operto, Anna T Giallonardo, Betul Baykan, Christoph P Beier, Carlo Di Bonaventura
Regulatory agencies have recently discouraged the prescription of topiramate (TPM) to women of childbearing potential with epilepsy due to growing evidence of the teratogenic and neurodevelopmental risks associated with its use during pregnancy. It remains, however, unclear whether the use of TPM in this population can be supported to some extent by its high effectiveness. In this multicenter, retrospective, cohort study performed at 22 epilepsy centers, we investigated the comparative effectiveness of TPM and levetiracetam (LEV) given as first-line antiseizure medication in a cohort of women of childbearing potential with idiopathic generalized epilepsy (IGE)...
January 31, 2024: Epilepsia