Marco Matejcic, Jamie K Teer, Hannah J Hoehn, Diana B Diaz, Kritika Shankar, Jun Gong, Nathalie T Nguyen, Nicole Lorona, Domenico Coppola, Clifton Fulmer, Ozlen Saglam, Kun Jiang, Douglas Cress, Teresita Muñoz-Antonia, Idhaliz Flores, Edna Gordian, José A Oliveras Torres, Seth I Felder, Julian A Sanchez, Jason Fleming, Erin M Siegel, Jennifer A Freedman, Julie Dutil, Mariana C Stern, Brooke L Fridley, Jane C Figueiredo, Stephanie L Schmit
UNLABELLED: Ancestrally diverse and admixed populations, including the Hispanic/Latino/a/x/e community, are underrepresented in cancer genetic and genomic studies. Leveraging the Latino Colorectal Cancer Consortium, we analyzed whole exome sequencing data on tumor/normal pairs from 718 individuals with colorectal cancer (128 Latino, 469 non-Latino) to map somatic mutational features by ethnicity and genetic ancestry. Global proportions of African, East Asian, European, and Native American ancestries were estimated using ADMIXTURE...
March 15, 2024: medRxiv