keyword
https://read.qxmd.com/read/38458869/evaluation-of-the-safety-profile-of-the-quadrivalent-vaccine-against-human-papillomavirus-in-the-risk-of-developing-autoimmune-neurological-and-hematological-diseases-in-adolescent-women-in-colombia
#1
JOURNAL ARTICLE
Ivette Maldonado, Nicolas Rodríguez Niño, Carlos F Valencia, Daniela Ortiz, Nathalia Ayala, Liz D'silva, Santiago Castro Villarreal, Diego Salazar, Catalina Lozano, Daniela Angulo
BACKGROUND: Cervical cancer eradication is one of the main goals for 2030 by the World Health Organization, which can only be achieved with high vaccination rates against Human Papilloma Virus. In Colombia, more and better scientific evidence is required to increase confidence in vaccination. The objective of this study is to evaluate the safety profile of the quadrivalent vaccine against HPV in the risk of developing autoimmune, neurological, and hematological diseases in adolescent women in Colombia...
March 7, 2024: Vaccine
https://read.qxmd.com/read/37882232/low-dose-il-2-therapy-in-autoimmune-diseases-an-update-review
#2
REVIEW
Ruizhi Zhang, Yuyang Zhao, Xiangming Chen, Zhuoqing Zhuang, Xiaomin Li, Erxia Shen
Regulatory T (Treg) cells are essential for maintaining self-immune tolerance. Reduced numbers or functions of Treg cells have been involved in the pathogenesis of various autoimmune diseases and allograft rejection. Therefore, the approaches that increase the pool or suppressive function of Treg cells in vivo could be a general strategy to treat different autoimmune diseases and allograft rejection. Interleukin-2 (IL-2) is essential for the development, survival, maintenance, and function of Treg cells, constitutively expressing the high-affinity receptor of IL-2 and sensitive response to IL-2 in vivo ...
October 26, 2023: International Reviews of Immunology
https://read.qxmd.com/read/37673192/paraneoplastic-autoimmune-laminin-332-syndrome-pals-anti-laminin-332-mucous-membrane-pemphigoid-as-a-prototype
#3
REVIEW
A Razzaque Ahmed, Mikole Kalesinskas, Sarah Kooper-Johnson
IMPORTANCE: Laminin-332 is an important component of the basement membrane. Recently, autoantibodies to Laminin-332 have been described in several autoimmune diseases. Many of these autoimmune diseases have a high incidence of malignancy. The importance of Laminin-332 autoantibodies and its relationship to malignancy is highlighted by using Laminin-332 Pemphigoid (LM-332Pg) as a prototype. OBJECTIVE: To identify several autoimmune diseases that have autoantibodies to Laminin-332 present, and to determine the prevalence of malignancy in them...
September 4, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/36716825/differences-in-igg-autoantibody-fab-glycosylation-across-autoimmune-diseases
#4
JOURNAL ARTICLE
Jana Koers, Rocco Sciarrillo, Ninotska I L Derksen, Esther M Vletter, Yvonne E Fillié-Grijpma, Elisabeth Raveling-Eelsing, Nuno A G Graça, Thiemo Leijser, Hendri H Pas, L Laura van Nijen-Vos, Maaike V J Braham, Anne-Marie Buisman, Jan de Jong, Angela I Schriek, Anne P Tio-Gillen, Y K Onno Teng, Maurice Steenhuis, Francis H Swaneveld, Steven W de Taeye, Marit J van Gils, Jan J G M Verschuuren, Bram Rutgers, Peter Heeringa, Barbara Horváth, Bart C Jacobs, Karina de Leeuw, Casper F M Franssen, Agnès Veyradier, Paul Coppo, Kyra A Gelderman, S Marieke van Ham, Cécile A C M van Els, Diane van der Woude, Ruth Huizinga, Maartje G Huijbers, Taco W Kuijpers, Rene E M Toes, Nicolaas A Bos, Theo Rispens
BACKGROUND: Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases. OBJECTIVE: To study if elevated Fab glycosylation is a common feature of autoimmunity, we investigated Fab glycosylation levels on serum IgG and its subclasses for autoantibodies associated with a range of different B cell-mediated autoimmune diseases, including rheumatoid arthritis, myasthenia gravis subtypes, pemphigus vulgaris, ANCA-associated vasculitis, systemic lupus erythematosus, anti-GBM glomerulonephritis, thrombotic thrombocytopenic purpura and Guillain-Barré syndrome...
January 27, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/36556100/immune-mediated-diseases-following-covid-19-vaccination-report-of-a-teaching-hospital-based-case-series
#5
JOURNAL ARTICLE
Eric Liozon, Matthieu Filloux, Simon Parreau, Guillaume Gondran, Holy Bezanahary, Kim-Heang Ly, Anne-Laure Fauchais
The occurrence and course of immune-mediated diseases (IMDs) following COVID-19 vaccination has been little explored so far. We retrieved, among adult patients hospitalized at the Internal Department of a French university hospital up to May 2022, all those who had developed, or relapsed to, an IMD less than 3 weeks following COVID-19 vaccination, without other triggers. Twenty-seven (24 new-onset) post-COVID-19 vaccine IMDs were recorded. They comprised giant cell arteritis or polymyalgia rheumatica ( n = 16, HLA-DRB1*04 in 58% of 12 assessed GCA cases), immune-mediated necrotizing myositis or acute rhabdomyolysis, systemic vasculitis, immune thrombocytopenic purpura, rheumatoid arthritis, anti-synthetase syndrome, and adult-onset Still's disease...
December 16, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36018829/full-length-recombinant-antibodies-from-escherichia-coli-production-characterization-effector-function-fc-engineering-and-clinical-evaluation
#6
REVIEW
Md Harunur Rashid
Although several antibody fragments and antibody fragment-fusion proteins produced in Escherichia coli ( E. coli ) are approved as therapeutics for various human diseases, a full-length monoclonal or a bispecific antibody produced in E. coli has not yet been approved. The past decade witnessed substantial progress in expression of full-length antibodies in the E. coli cytoplasm and periplasm, as well as in cell-free expression systems. The equivalency of E. coli -produced aglycosylated antibodies and their mammalian cell-produced counterparts, with respect to biochemical and biophysical properties, including antigen binding, in vitro and in vivo serum stability, pharmacokinetics, and in vivo serum half-life, has been demonstrated...
January 2022: MAbs
https://read.qxmd.com/read/35628931/bruton-s-kinase-inhibitors-for-the-treatment-of-immunological-diseases-current-status-and-perspectives
#7
REVIEW
Ewa Robak, Tadeusz Robak
The use of Bruton's tyrosine kinase (BTK) inhibitors has changed the management of patients with B-cell lymphoid malignancies. BTK is an important molecule that interconnects B-cell antigen receptor (BCR) signaling. BTK inhibitors (BTKis) are classified into three categories, namely covalent irreversible inhibitors, covalent reversible inhibitors, and non-covalent reversible inhibitors. Ibrutinib is the first covalent, irreversible BTK inhibitor approved in 2013 as a breakthrough therapy for chronic lymphocytic leukemia patients...
May 16, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35434592/sars-cov2-acute-and-post-active-infection-in-the-context-of-autoimmune-and-chronic-inflammatory-diseases
#8
JOURNAL ARTICLE
Regina Larionova, K Byvaltsev, Оlga Kravtsova, Elena Takha, Sergei Petrov, Gevorg Kazarian, Anna Valeeva, Eduard Shuralev, Malik Mukminov, Yves Renaudineau, Marina Arleevskaya
The clinical and immunological spectrum of acute and post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Indeed, following SARS-Cov2 infection, the innate immune response is altered with an initial delayed production of interferon type I (IFN-I), while the NF-kappa B and inflammasome pathways are activated. In lung and digestive tissues, an alternative and extrafollicular immune response against SARS-Cov2 takes place with, consequently, an altered humoral and memory T cell response leading to breakdown of tolerance with the emergence of autoantibodies...
2022: Journal of translational autoimmunity
https://read.qxmd.com/read/35366433/hmgb1-is-increased-in-patients-with-immune-thrombocytopenia-and-negatively-associates-with-tregs
#9
JOURNAL ARTICLE
Guoyang Zhang, Pengfeng Yang, Xiaoyan Liu, Hongyun Liu, Jue Wang, Jieyu Wang, Jie Xiao, Danian Nie, Liping Ma
INTRODUCTION: Refractory or recurrent immune thrombocytopenia (ITP) patients suffer from the dual threat of high mortality and drug toxicity in addition to a very poor quality of life. Previous studies have shown that high mobility group box 1 (HMGB1) can promote the development of rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases. However, there is still a lack of research on the role of HMGB1 in the pathogenesis of ITP and whether it can be used as a predictor of efficacy and prognosis...
May 2022: Thrombosis Research
https://read.qxmd.com/read/35054471/covid-19-a-trigger-factor-for-severe-immune-mediated-thrombocytopenia-in-active-rheumatoid-arthritis
#10
JOURNAL ARTICLE
Anca Bobircă, Florin Bobircă, Ioan Ancuța, Anca Florescu, Mihai Bojincă, Alice Muscă, Dan Nicolae Florescu, Lucian Mihai Florescu, Romina Marina Sima, Alesandra Florescu, Anca Emanuela Mușetescu
Thrombocytopenia is defined as a platelet count below 150,000/mm3 for adults. There is still controversy about whether individuals with platelet counts of 100,000/mm3 to 150,000/mm3 should be classified as having genuine thrombocytopenia or borderline thrombocytopenia. Thrombocytopenia is considered mild when the platelet count is between 70,000 and 150,000/mm3 and severe if the count is less than 20,000/mm3 . Thrombocytopenia in rheumatoid arthritis is a rare complication, with an incidence estimated between 3 and 10%...
January 6, 2022: Life
https://read.qxmd.com/read/35029180/early-treatment-of-rituximab-combined-with-eltrombopag-for-secondary-thrombocytopenic-purpura-in-rheumatoid-arthritis-a-case-report
#11
JOURNAL ARTICLE
Naidan Zhang, Chaixia Ji, Xiao Bao, Chengliang Yuan
RATIONALE: Secondary immune thrombocytopenic purpura (ITP) is also known as acquired thrombocytopenic purpura, autoimmune disease is usually one of the important causes. There are few reports about treatment of refractory thrombocytopenic purpura in rheumatoid arthritis (RA). We report a case of refractory ITP in which changes in platelet-related markers with therapeutic agents are worthy of the attention of clinicians. PATIENT CONCERNS: A 69-year-old woman admitted for ecchymosis on the neck and arms for 15 days presented to our hospital...
January 14, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/34803999/bruton-s-tyrosine-kinase-btk-inhibitors-and-autoimmune-diseases-making-sense-of-btk-inhibitor-specificity-profiles-and-recent-clinical-trial-successes-and-failures
#12
REVIEW
Garth E Ringheim, Matthew Wampole, Kinsi Oberoi
Clinical development of BTK kinase inhibitors for treating autoimmune diseases has lagged behind development of these drugs for treating cancers, due in part from concerns over the lack of selectivity and associated toxicity profiles of first generation drug candidates when used in the long term treatment of immune mediated diseases. Second generation BTK inhibitors have made great strides in limiting off-target activities for distantly related kinases, though they have had variable success at limiting cross-reactivity within the more closely related TEC family of kinases...
2021: Frontiers in Immunology
https://read.qxmd.com/read/34326842/predictive-value-of-high-icam-1-level-for-poor-treatment-response-to-low-dose-decitabine-in-adult-corticosteroid-resistant-itp-patients
#13
JOURNAL ARTICLE
Chaoyang Li, Lizhen Li, Meng Sun, Jianzhi Sun, Linlin Shao, Miao Xu, Yu Hou, Jun Peng, Lin Wang, Ming Hou
Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease. Endothelial cell activation/injury has been found in some autoimmune diseases including SLE, systemic sclerosis, and rheumatoid arthritis, but its role in ITP pathogenesis remains unclear. This study attempted to elucidate the correlation between endothelial dysfunction and disease severity of ITP and find related markers to predict response to low-dose decitabine treatment. Compared with healthy volunteers, higher plasma levels of soluble intercellular adhesion molecule-1 (ICAM-1), vascular endothelial growth factor (VEGF), and Angiopoietin-2 were found in adult corticosteroid resistant ITP patients...
2021: Frontiers in Immunology
https://read.qxmd.com/read/33875273/emerging-roles-of-coronavirus-in-autoimmune-diseases
#14
REVIEW
Si-Yu Zhou, Chi Zhang, Wen-Jing Shu, Li-Ye Chong, Jun He, Zhiwei Xu, Hai-Feng Pan
Virus infection can alter immune regulatory activity, and thus may be involved in the occurrence of autoimmune diseases. Recently, the pandemic of COVID-19 has posed a huge threat to public health and emerging evidence suggests that coronavirus may be implicated in the development and pathogenesis of autoimmune diseases. However, how coronavirus infection impacts the risk of autoimmune disease remains largely unknown. In this review, we focused on the association between coronavirus and autoimmunity, and elucidated the molecular mechanisms linking coronavirus exposure to autoimmunity...
October 2021: Archives of Medical Research
https://read.qxmd.com/read/33810369/autoimmune-complications-in-hematologic-neoplasms
#15
REVIEW
Wilma Barcellini, Juri Alessandro Giannotta, Bruno Fattizzo
Autoimmune cytopenias (AICy) and autoimmune diseases (AID) can complicate both lymphoid and myeloid neoplasms, and often represent a diagnostic and therapeutic challenge. While autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP) are well known, other rarer AICy (autoimmune neutropenia, aplastic anemia, and pure red cell aplasia) and AID (systemic lupus erythematosus, rheumatoid arthritis, vasculitis, thyroiditis, and others) are poorly recognized. This review analyses the available literature of the last 30 years regarding the occurrence of AICy/AID in different onco-hematologic conditions...
March 26, 2021: Cancers
https://read.qxmd.com/read/33356722/immunomodulatory-cytokine-interleukin-35-and-immune-thrombocytopaenia
#16
REVIEW
Jing-Jing Zhu, Ning-Ning Shan
Considerable attention has been paid to interleukin (IL)-35 because of its immunosuppressive effects in a variety of autoimmune diseases. IL-35, a recently identified cytokine of the IL-12 family, is a negative regulatory factor secreted by IL-35-inducible regulatory T cells (iTr35 cells) and the recently reported regulatory B cells (Breg cells). Four biological effects of IL-35 have been discovered in vitro and in vivo : (i) suppression of T cell proliferation; (ii) conversion of naive T cells into iTr35 cells; (iii) downregulation of type 17 helper T (Th 17) cells; and (iv) conversion of Breg cells into a Breg subset that produces IL-35 and IL-10...
December 2020: Journal of International Medical Research
https://read.qxmd.com/read/33123604/identification-of-long-noncoding-rnas-lnc-dc-in-plasma-as-a-new-biomarker-for-primary-sj%C3%A3-gren-s-syndrome
#17
JOURNAL ARTICLE
Yanhong Chen, Yongqiang Chen, Beibei Zu, Jia Liu, Li Sun, Chen Ding, Duping Wang, Xing Cheng, DeLiang Yang, Guoping Niu
OBJECTIVE: To evaluate the plasma levels of lnc-DC in primary Sjögren's syndrome (pSS) patients and investigate the potential associations between lnc-DC and disease activity. METHODS: In this study, we recruited 358 enrollments, including 127 pSS patients without immune thrombocytopenia (ITP), 22 pSS patients with ITP, 50 systemic lupus erythematosus (SLE) patients, and 50 patients with rheumatoid arthritis (RA) and 109 healthy individuals, from Xuzhou Central Hospital...
2020: Journal of Immunology Research
https://read.qxmd.com/read/31837028/isoagglutinin-reduced-immunoglobulin-retains-efficacy-in-mouse-models-of-immune-thrombocytopenia-and-rheumatoid-arthritis-and-is-less-likely-to-cause-intravenous-immunoglobulin-associated-hemolysis
#18
JOURNAL ARTICLE
Selena Y Cen, Donald R Branch
BACKGROUND: Immunoglobulin therapy including intravenous immunoglobulin (IVIg) has been used as an effective treatment for autoimmune/inflammatory conditions with few side effects. However, high-dose IVIg (1-2 g/kg) has been recognized as a cause of hemolytic anemia in non-blood group O patients. Hemolysis when observed has been due to anti-A/anti-B isoagglutinins contained in the IVIg. Recently, an isoagglutinin-reduced IVIg, whereby the anti-A and anti-B titers have been reduced by immunoaffinity chromatography, has been introduced; however, whether this new product is as efficacious as nonreduced immunoglobulin (Ig) or will result in less IVIg-associated hemolysis has not been resolved...
February 2020: Transfusion
https://read.qxmd.com/read/31325552/comorbid-diseases-of-vitiligo-a-10-year-cross-sectional-retrospective-study-of-an-urban-us-population
#19
JOURNAL ARTICLE
Ali Hadi, Jason F Wang, Pushpinder Uppal, Lauren A Penn, Nada Elbuluk
BACKGROUND: Vitiligo is associated with medical conditions, primarily autoimmune disorders; however, only a few studies in the United States have investigated these associations. OBJECTIVE: Our purpose was to investigate the diseases associated with vitiligo in the New York, New York, population and evaluate if these associations differ by race/ethnicity and sex. METHODS: In this retrospective study, we analyzed data collected from the medical records of 1487 vitiligo patients seen at New York University during a 10-year period...
March 2020: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30773373/clinical-significance-and-immunobiology-of-il-21-in-autoimmunity
#20
REVIEW
Di Long, Yongjian Chen, Haijing Wu, Ming Zhao, Qianjin Lu
Interleukin-21 (IL-21), an autocrine cytokine predominantly produced by follicular helper T (Tfh) and T helper 17 (Th17) cells, has been proven to play an important role in the immune system, for example, by promoting proliferation and the development of Tfh and Th17 cells, balancing helper T cell subsets, inducing B cell generation and differentiation into plasma cells, and enhancing the production of immunoglobulin. These effects are mainly mediated by activation of the JAK/STAT, MAPK and PI3K pathways...
May 2019: Journal of Autoimmunity
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