Jana Koers, Rocco Sciarrillo, Ninotska I L Derksen, Esther M Vletter, Yvonne E Fillié-Grijpma, Elisabeth Raveling-Eelsing, Nuno A G Graça, Thiemo Leijser, Hendri H Pas, L Laura van Nijen-Vos, Maaike V J Braham, Anne-Marie Buisman, Jan de Jong, Angela I Schriek, Anne P Tio-Gillen, Y K Onno Teng, Maurice Steenhuis, Francis H Swaneveld, Steven W de Taeye, Marit J van Gils, Jan J G M Verschuuren, Bram Rutgers, Peter Heeringa, Barbara Horváth, Bart C Jacobs, Karina de Leeuw, Casper F M Franssen, Agnès Veyradier, Paul Coppo, Kyra A Gelderman, S Marieke van Ham, Cécile A C M van Els, Diane van der Woude, Ruth Huizinga, Maartje G Huijbers, Taco W Kuijpers, Rene E M Toes, Nicolaas A Bos, Theo Rispens
BACKGROUND: Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases. OBJECTIVE: To study if elevated Fab glycosylation is a common feature of autoimmunity, we investigated Fab glycosylation levels on serum IgG and its subclasses for autoantibodies associated with a range of different B cell-mediated autoimmune diseases, including rheumatoid arthritis, myasthenia gravis subtypes, pemphigus vulgaris, ANCA-associated vasculitis, systemic lupus erythematosus, anti-GBM glomerulonephritis, thrombotic thrombocytopenic purpura and Guillain-Barré syndrome...
January 27, 2023: Journal of Allergy and Clinical Immunology