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peripheral neuropathy not diabetic

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https://www.readbyqxmd.com/read/29672293/microarray-analysis-of-long-noncoding-rnas-in-female-diabetic-peripheral-neuropathy-patients
#1
Lin Luo, Lin-Dan Ji, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Wen-Hua Zhou
BACKGROUND/AIMS: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Because of its controversial pathogenesis, DPN is still not diagnosed or managed properly in most patients. METHODS: In this study, human lncRNA microarrays were used to identify the differentially expressed lncRNAs in DM and DPN patients, and some of the discovered lncRNAs were further validated in additional 78 samples by quantitative realtime PCR (qRT-PCR)...
April 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29661547/influence-of-injection-volume-on-rate-of-subsequent-intervention-in-carpal-tunnel-syndrome-over-1-year-follow-up
#2
Stefanie Evers, Andrew J Bryan, Thomas L Sanders, Tina Gunderson, Russell Gelfman, Peter C Amadio
PURPOSE: The optimal volume and dose of corticosteroid injections for treatment of carpal tunnel syndrome (CTS) have not yet been established. It is unknown whether the volume of injectate influences the outcome of carpal tunnel injection. The purpose of this study was to assess whether there is an association between the volume of injectate and subsequent intervention in the treatment of CTS. METHODS: This study evaluated residents of Olmsted County, MN, who were treated with a corticosteroid injection for CTS between 2001 and 2010...
April 13, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#3
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29649429/deletion-of-the-insulin-receptor-in-sensory-neurons-increases-pancreatic-insulin-levels
#4
Caleb W Grote, Natalie M Wilson, Natalie K Katz, Brianne L Guilford, Janelle M Ryals, Lesya Novikova, Lisa Stehno-Bittel, Douglas E Wright
Insulin is known to have neurotrophic properties and loss of insulin support to sensory neurons may contribute to peripheral diabetic neuropathy (PDN). Here, genetically-modified mice were generated in which peripheral sensory neurons lacked the insulin receptor (SNIRKO mice) to determine whether disrupted sensory neuron insulin signaling plays a crucial role in the development of PDN and whether SNIRKO mice develop symptoms of PDN due to reduced insulin neurotrophic support. Our results revealed that SNIRKO mice were euglycemic and never displayed significant changes in a wide range of sensorimotor behaviors, nerve conduction velocity or intraepidermal nerve fiber density...
April 9, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29629375/arterial-stiffness-is-associated-with-peripheral-sensory-neuropathy-in-diabetes-patients-in-ghana
#5
Kwame Yeboah, Jennifer A Agyekum, Richard N A Owusu Mensah, Patrick K Affrim, Linda Adu-Gyamfi, Rita O Doughan, Afua B Adjei
Objective: Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation. Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes. We investigated the association between PSN and arterial stiffness, measured as aortic pulse wave velocity (PWVao) and cardio-ankle vascular index (CAVI). Method: In a case-control design, arterial stiffness was measured in 240 diabetes patients and 110 nondiabetic control...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29615658/systemic-igf-1-gene-delivery-by-raav9-improves-spontaneous-autoimmune-peripheral-polyneuropathy-sapp
#6
Tong Gao, Nataliia Bogdanova, Sameera Ghauri, Gang Zhang, Jianxin Lin, Kazim Sheikh
Spontaneous autoimmune peripheral polyneuropathy (SAPP) is a mouse model of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in non-obese diabetic (NOD) mice null for costimulatory molecule, B7-2 gene (B7-2-/- ). SAPP is a chronic progressive and multifocal inflammatory and demyelinating polyneuropathy of spontaneous onset with secondary axonal degeneration. Insulin-like growth factor 1(IGF-1) is a pleiotropic factor with neuroprotective, regenerative, and anti-inflammatory effects with extensive experience in its preclinical and clinical use...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29607003/patients-with-type-2-diabetes-demonstrate-proprioceptive-deficit-in-the-knee
#7
Lucas Richard Ettinger, Ami Boucher, Elisabeth Simonovich
AIM: To investigate proprioceptive discrepancies in the lower extremity in persons with type 2 diabetes mellitus (T2DM). METHODS: In this cross-sectional study, a total of 46 older persons were divided into a T2DM group ( n = 23) and a control group who did not have T2DM ( n = 23). Participants were given a brief warm up with stretching exercises. Diabetic neuropathy scores were collected prior to proprioceptive testing. For proprioceptive testing, participants performed leg extensions to randomized target positions of 15°, 30°, 45, 60° degrees of elevation in the sagittal plane, each target was repeated a total of four times...
March 15, 2018: World Journal of Diabetes
https://www.readbyqxmd.com/read/29606547/effect-of-aerobic-training-on-nerve-conduction-in-men-with-type-2-diabetes-and-peripheral-neuropathy-a-randomized-controlled-trial
#8
Farhad Gholami, Saeed Nikookheslat, Yaghoub Salekzamani, Normand Boule, Afshar Jafari
OBJECTIVE: Peripheral neuropathy (PN) is one of the long-term complications of diabetes. Few studies have investigated the role of regular exercise on diabetic PN. We examined the effect of aerobic training on nerve conduction velocity and action potential amplitude in the lower limbs of men with type 2 diabetes and PN. METHODS: In a randomized controlled study, 24 volunteers diagnosed with diabetic PN were randomly assigned to exercise or control groups. Aerobic training consisted of 20-45min walking or running at 50-70% of heart rate reserve for three sessions per week over 12weeks...
March 29, 2018: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/29597081/a-comparison-of-the-assay-sensitivity-of-average-and-worst-pain-intensity-in-pharmacologic-trials-an-acttion-systematic-review-and-meta-analysis
#9
REVIEW
Shannon M Smith, Mark P Jensen, Hua He, Rachel Kitt, James Koch, Andrew Pan, Laurie B Burke, John T Farrar, Michael P McDermott, Dennis C Turk, Robert H Dworkin
Identifying methods to improve assay sensitivity in randomized clinical trials (RCTs) may facilitate the discovery of efficacious pain treatments. RCTs evaluating pain treatments typically use average pain intensity (API) or worst pain intensity (WPI) as the primary efficacy outcome. However, little evidence is available comparing the assay sensitivity of these 2 measures. In this systematic review and meta-analysis, we comprehensively reviewed all low back pain, osteoarthritis pain, fibromyalgia, diabetic peripheral neuropathy pain, and postherpetic neuralgia RCTs that used a parallel group design...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29589820/text-messaging-to-improve-disease-management-in-patients-with-painful-diabetic-peripheral-neuropathy
#10
Victoria Bauer, Nancy Goodman, Brittany Lapin, Camille Cooley, Ed Wang, Terri L Craig, Scott E Glosner, Mark S Juhn, Joseph C Cappelleri, Alesia B Sadosky, Christopher Masi
Purpose The purpose of the study was to determine the impact of educational text messages on diabetes self-management activities and outcomes in patients with painful diabetic peripheral neuropathy (pDPN). Methods Patients with pDPN identified from a large integrated health system who agreed to participate were randomized to 6 months of usual care (UC) or UC plus twice-daily diabetes self-management text messages (UC+TxtM). Outcomes included the Pain Numerical Rating Scale, Summary of Diabetes Self-Care Activities (SDSCA), questions on diabetes health beliefs, and glycated hemoglobin (A1C)...
March 1, 2018: Diabetes Educator
https://www.readbyqxmd.com/read/29578944/efficacy-of-the-nav1-7-blocker-pf-05089771-in-a-randomised-placebo-controlled-double-blind-clinical-study-in-subjects-with-painful-diabetic-peripheral-neuropathy
#11
Aoibhinn Mc Donnell, Susie Collins, Zahid Ali, Laura Iavarone, Raulin Surujbally, Simon Kirby, Richard P Butt
The effect of PF-05089771, a selective, peripherally restricted Nav1.7 sodium channel blocker on pain due diabetic peripheral neuropathy was investigated in a randomised, placebo and active-controlled parallel group clinical trial (NCT02215252). A 1-week placebo-run in period was followed by a 4-week treatment period and a 1-week placebo run-out/taper down period. Single-blind placebo was administered throughout run-in and run-out periods. Subjects were randomised to receive either PF-05089771 150 mg BID, pregabalin 150 mg BID or placebo during the 4-week treatment period...
March 23, 2018: Pain
https://www.readbyqxmd.com/read/29567079/early-onset-physical-frailty-in-adults-with-diabesity-and-peripheral-neuropathy
#12
Lori J Tuttle, Daniel C Bittel, Adam J Bittel, David R Sinacore
OBJECTIVES: Diabesity (obesity and diabetes mellitus) has been identified as a potential contributor to early-onset frailty. Impairments contributing to early onset of physical frailty in this population are not well understood, and there is little evidence of the impact of peripheral neuropathy on frailty. The purpose of this study was to determine impairments that contribute to early-onset physical frailty in individuals with diabesity and peripheral neuropathy. METHODS: We studied 105 participants, 82 with diabesity and peripheral neuropathy (57 years of age, body mass index [BMI] 31 kg/m2 ); 13 with diabesity only (53 years of age, BMI 34 kg/m2 ) and 10 obese controls (67 years of age, BMI 32 kg/m2 )...
December 7, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29565948/a-randomized-double-blind-study-of-the-effects-of-a-sustained-release-formulation-of-sodium-nitrite-sr-nitrite-on-patients-with-diabetic-neuropathy
#13
Amol Soin, Glen Bock, Anthony Giordano, Chirag Patel, David Drachman
BACKGROUND: Sodium nitrite has been reported to be effective in reducing chronic peripheral pain. OBJECTIVES: To evaluate the safety and efficacy of 40 and 80 mg, BID, of an oral sustained release formulation of sodium nitrite (SR-nitrite) in patients suffering from diabetic neuropathy, and to determine whether SR-nitrite would reduce the frequency of headaches reported previously by subjects receiving the same doses of an immediate release formulation. STUDY DESIGN: Phase II, single-center, randomized, double-blind, placebo controlled clinical trial...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29563324/binding-characteristics-and-analgesic-effects-of-mirogabalin-a-novel-ligand-for-the-%C3%AE-2-%C3%AE-subunit-of-voltage-gated-calcium-channels
#14
Yuki Domon, Naohisa Arakawa, Tatsuya Inoue, Fumihiko Matsuda, Makoto Takahashi, Naotoshi Yamamura, Kiyonori Kai, Yutaka Kitano
Mirogabalin ([(1 R ,5 S ,6 S )-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the α2 δ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. In the present study, we investigated the in vitro binding characteristics and in vivo analgesic effects of mirogabalin, compared to those of pregabalin, a standard α2 δ ligand. Mirogabalin showed potent and selective binding affinities for the α2 δ subunits, while having no effects on 186 off-target proteins...
March 21, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29544239/-transthyretin-familial-amyloid-polyneuropathy-disease-profile-of-a-multisystem-disorder
#15
Christoph Niemietz, Christoph Röcken, Matthias Schilling, Jörg Stypman, Constantin E Uhlig, Hartmut H-J Schmidt
Transthyretin-related Familial Amyloid Polyneuropathy (ATTR Amyloidosis, former FAP, here called TTR-FAP) is a rare, progressive autosomal dominant inherited amyloid disease ending fatal within 5 - 15 years after final diagnosis. TTR-FAP is caused by mutations of transthyretin (TTR), which forms amyloid fibrils affecting peripheral and autonomic nerves, the heart and other organs. Due to the phenotypic heterogeneity and partly not specific enough clinical symptoms, diagnosis of TTR-FAP can be complicated...
March 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29527628/efficiencies-of-low-level-laser-therapy-lllt-and-gabapentin-in-the-management-of-peripheral-neuropathy-diabetic-neuropathy
#16
Khaled G Abdel-Wahhab, Eitedal M Daoud, Aliaa El Gendy, Hagar H Mourad, Fathia A Mannaa, Maha M Saber
Diabetic neuropathy (DN) is the highly occurred complication of diabetes mellitus; it has been defined as an event of peripheral nerve dysfunction characterized by pain, allodynia, hyperalgesia, and paraesthesia. The current study was conducted to evaluate the efficacy of low-level laser therapy (LLLT) in the management of neuropathy in diabetic rats. The used animals were divided into the following groups: negative control, streptozotocin-induced diabetic rats, and diabetic rats with peripheral neuropathy (DNP) and DNP treated with gabapentin or with LLLT...
March 12, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29504257/correlation-of-retinal-neurodegeneration-with-measures-of-peripheral-autonomic-neuropathy-in-type-1-diabetes
#17
Berthold Pemp, Stefan Palkovits, Kinga Howorka, Jiri Pumprla, Stefan Sacu, Gerhard Garhöfer, Michaela Bayerle-Eder, Leopold Schmetterer, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation...
March 5, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29500139/assessing-the-risk-for-peripheral-neuropathy-in-patients-treated-with-dronedarone-compared-with-that-in-other-antiarrhythmics
#18
Chuntao Wu, Stephanie Tcherny-Lessenot, Wanju Dai, Yunxun Wang, Hayet Kechemir, Sampada Gandhi, Stephen Lin, Juhaeri Juhaeri
PURPOSE: There are few data on the risk for peripheral neuropathy associated with dronedarone, a newer antiarrhythmic medicine. The objective of this study was to assess whether dronedarone is potentially associated with an increased risk for peripheral neuropathy compared with other antiarrhythmics, including amiodarone, sotalol, flecainide, and propafenone. METHODS: The MarketScan database was used for identifying patients who were at least 18 years of age, had atrial fibrillation or flutter, and had not been diagnosed with peripheral neuropathy in the 180-day period prior to or on the date of the first prescription of an antiarrhythmic between July 20, 2009, and December 31, 2011...
February 27, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29488552/-safety-of-fluoroquinolones-risks-usually-forgotten-for-the-clinician
#19
Claudio González M, Ruth Rosales C, Daniela Pavez, Luz M Fuenzalida, Andrés Soto, Regina Pérez, Jorge Pérez, Rafael Araos, M Eugenia Pinto
Quinolones are a group of widely used antimicrobials. Although they are considered safe for patients, knowledge of the safety profile is necessary so that professionals become aware of what is necessary to monitor. At the musculoskeletal level, quinolones have the potential to damage cartilage, causing even tendon rupture in infrequent cases. Hypoglycemia / hyperglycemia has been observed at the endocrine level, thus, careful monitoring of glycemia in patients with quinolone is recommended in diabetic patients...
December 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29476444/dose-titration-of-pregabalin-in-patients-with-painful-diabetic-peripheral-neuropathy-simulation-based-on-observational-study-patients-enriched-with-data-from-randomized-studies
#20
Joe Alexander, Roger A Edwards, Luigi Manca, Roberto Grugni, Gianluca Bonfanti, Birol Emir, Edward Whalen, Stephen Watt, Bruce Parsons
INTRODUCTION: Achieving a therapeutic response to pregabalin in patients with painful diabetic peripheral neuropathy (pDPN) requires adequate upward dose titration. Our goal was to identify relationships between titration and response to pregabalin in patients with pDPN. METHODS: Data were integrated from nine randomized, placebo-controlled clinical trials as well as one 6-week open-label observational study conducted by 5808 physicians (2642 patients with pDPN) in standard outpatient settings in Germany...
February 23, 2018: Advances in Therapy
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