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peripheral neuropathy not diabetic

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https://www.readbyqxmd.com/read/27901334/differential-efficacy-of-methylcobalamin-and-alpha-lipoic-acid-treatment-on-negative-and-positive-symptoms-of-type-2-diabetic-peripheral-neuropathy
#1
Yajuan Han, Min Wang, Jie Shen, Zhen Zhang, Min Zhao, Jing Huang, Youming Chen, Zhi Chen, Yulan Hu, Yubing Wang
BACKGROUND: Diabetic hyperglycemia damages peripheral nerves by triggering ischemia, oxidative stress, and inflammation. Alpha-lipoic acid (ALA) and methylcobalamin (MC) are known to improve signs of diabetic peripheral neuropathy (DPN), possibly by enhancing neural and vascular endothelial cell metabolism and antioxidant capacity. We evaluated differences in efficacy following short-term MC or ALA treatment on DPN symptoms to guide clinical drug selection. METHODS: Forty DPN patients were randomly divided into MC and ALA treatment groups (n=20/20) and assessed by the Toronto Clinical Neuropathy Scoring System (TCSS), total symptom score (TSS), visual analog scale (VAS) of positive symptoms, and easy sensory test (EST) for negative symptoms before and after 2 weeks of treatment...
November 30, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27898216/characterization-of-prostacyclin-associated-leg-pain-in-patients-with-pulmonary-arterial-hypertension
#2
Gabriel L Pagani-Estévez, Keith M Swetz, Michael D McGoon, Robert P Frantz, Susan K Tointon, Ann M Karnyski, Louise A Durst, James C Watson
RATIONALE: Prostacyclin-associated leg pain is a potentially debilitating adverse effect of prostacyclin therapy for patients with pulmonary arterial hypertension (PAH). However, to our knowledge, this entity has not been systematically studied. OBJECTIVE: To characterize the clinical features and metabolic risk factors for prostacyclinassociated leg pain. METHODS: At one academic medical center we assembled and analyzed a case series of patients with PAH and prostacyclin-associated leg pain...
November 29, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27889823/goshajinkigan-for-reducing-chemotherapy-induced-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#3
Nobuaki Hoshino, Koya Hida, Riki Ganeko, Yoshiharu Sakai
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is an issue for both cancer patients and specialists, and the number of cases of CIPN is growing with the increasing number of cancer patients worldwide. CIPN is often caused by common anticancer drugs such as taxanes and platinum analogs. These are key drugs for various cancers including colorectal and gastric cancers. However, there are currently no effective drugs to prevent CIPN. Goshajinkigan, a Japanese traditional herbal medicine (Kampo), is a promising drug which is used to treat diabetic neuropathy in Japan...
November 26, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27882360/static-and-dynamic-predictors-of-foot-progression-angle-in-individuals-with-and-without-diabetes-mellitus-and-peripheral-neuropathy
#4
Ericka N Merriwether, Mary K Hastings, Michael J Mueller, Kathryn L Bohnert, Michael J Strube, Darrah R Snozek, David R Sinacore
INTRODUCTION: Foot progression angle (FPA) is a predictor of elevated regional plantar stresses and loads, which are indicators of dermal injury risk in individuals with diabetes mellitus and peripheral neuropathy (DMPN). FPA accounts for 15-45% of the variance in plantar stresses and loads in adults with DMPN. However, the biomechanical factors underlying an "out-toeing" gait pattern in this clinical population have not been examined. The primary purpose of this study was to identify static and dynamic predictors of foot progression angle magnitude in adults with and without DMPN...
2016: Annals of Gerontology and Geriatric Research
https://www.readbyqxmd.com/read/27881717/localization-of-1-deoxysphingolipids-to-mitochondria-induces-mitochondrial-dysfunction
#5
Irina Alecu, Andrea Tedeschi, Natascha Behler, Klaus Wunderling, Christian Lamberz, Mario A R Lauterbach, Anne Gaebler, Daniela Ernst, Paul P Van Veldhoven, Ashraf Al-Amoudi, Eicke Latz, Alaa Othman, Lars Kuerschner, Thorsten Hornemann, Frank Bradke, Christoph Thiele, Anke Penno
1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and autonomic neuropathy type 1 (HSAN1). Clinically, diabetic neuropathy and HSAN1 are very similar, suggesting the involvement of deoxySLs in the pathology of both diseases. However, very little is known about the biology of these lipids and the underlying pathomechanism. We synthesized an alkyne analogue of 1-deoxysphinganine (doxSA), the metabolic precursor of all deoxySLs, to trace the metabolism and localization of deoxySLs...
November 23, 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27863489/the-effect-of-cumulative-glycemic-burden-on-the-incidence-of-diabetic-foot-disease
#6
Robert G Dekker, Charles Qin, Bryant S Ho, Anish R Kadakia
BACKGROUND: Glycemic control is a known modifiable risk factor for diabetic foot disease. Prior attempts to define its relationship with diabetic foot ulcer and Charcot arthropathy fail to account for variability in control and duration of diabetic disease. We developed a novel metric to reflect aggregate disease exposure in a diabetic, termed cumulative glycemic burden. We hypothesized that it would be positively associated with both diabetic foot ulcer and radiographically diagnosed Charcot arthropathy...
November 18, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27854094/cubital-tunnel-syndrome-caused-by-ulnar-nerve-schwannoma-in-a-patient-with-diabetic-sensorimotor-polyneuropathy
#7
Meng-Ta Liu, Jiunn-Tay Lee, Chih-Hsin Wang, Yu-Chieh Lin, Chung-Hsing Chou
PURPOSE: An uncommon ulnar nerve schwannoma should not be neglected in a diabetic patient with cubital tunnel syndrome, the second most common cause of entrapment neuropathy. CASE REPORT: A 61-year-old woman with a past history of type 2 diabetes mellitus complicated with sensorimotor polyneuropathy presented with progressive numbness and weakness of the left ring and little fingers for one year. A provisional diagnosis of cubital tunnel syndrome was made according to physical examination and electrophysiological studies...
June 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27814471/reference-data-of-the-european-organisation-for-research-and-treatment-of-cancer-eortc-qlq-cipn20-questionnaire-in-the-general-dutch-population
#8
Floortje Mols, Lonneke V van de Poll-Franse, Gerard Vreugdenhil, Antoinetta J Beijers, Jacobien M Kieffer, Neil K Aaronson, Olga Husson
OBJECTIVE: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side-effect of chemotherapy. However, CIPN symptoms are also reported by patients not receiving chemotherapy. Normative data could help interpret CIPN among cancer patients. Our aim was to generate normative data for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 Questionnaire designed to assess CIPN from the patients' perspective. The normative CIPN data have also been generated for stratified subgroups formed on the basis of sex, age and comorbidity...
November 1, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27813425/emerging-drugs-for-diabetic-peripheral-neuropathy-and-neuropathic-pain
#9
Nikolaos Papanas, Dan Ziegler
Diabetic sensorimotor polyneuropathy (DSPN) is a common complication of diabetes. Areas covered: In this review, the authors discuss the emerging drugs for DSPN, which aim either at improving alleviation of neuropathic pain or addressing the putative mechanisms underlying diabetic neuropathy. Expert Opinion: Current treatment does not address the sensory deficits and pathogenesis underlying DSPN, so there is an unmet need for treatment options targeting the natural history of the condition. Some of these pathogenetic therapies have demonstrated clinically relevant improvements in neuropathic endpoints in recent randomised controlled trials...
November 4, 2016: Expert Opinion on Emerging Drugs
https://www.readbyqxmd.com/read/27812455/kinetics-and-kinematics-of-diabetic-foot-in-type-2-diabetes-mellitus-with-and-without-peripheral-neuropathy-a-systematic-review-and-meta-analysis
#10
REVIEW
Animesh Hazari, Arun G Maiya, K N Shivashankara, Ioannis Agouris, Ashma Monteiro, Radhika Jadhav, Sampath Kumar, C G Shashi Kumar, Shreemathi S Mayya
BACKGROUND: Diabetes mellitus patients are at increased risk of developing diabetic foot with peripheral neuropathy, vascular and musculoskeletal complications. Therefore they are prone to develop frequent and often foot problems with a relative high risk of infection, gangrene and amputation. In addition, altered plantar pressure distribution is an important etiopathogenic risk factor for the development of foot ulcers. Thus the review on study of foot kinematic and kinetic in type 2 diabetes mellitus to understand the biomechanical changes is important...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27790428/glycaemia-status-lipid-profile-and-renal-parameters-in-progressive-diabetic-neuropathy
#11
Debahuti Mohapatra, Komaladevi Sampath Damodar
INTRODUCTION: Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes. Existence of systemic co-morbidities in DPN patients has not been studied much, especially in Indian population. AIM: To evaluate glycaemic status, lipid profile, renal parameters and blood count to assess occurrence of co-morbidities as severity of DPN progresses. MATERIALS AND METHODS: A case control study involving 104 DPN patients and 43 controls of age 31-70years were selected...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785092/improvement-in-pain-severity-category-in-clinical-trials-of-pregabalin
#12
Bruce Parsons, Charles E Argoff, Andrew Clair, Birol Emir
BACKGROUND: Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM), diabetic peripheral neuropathy (DPN), postherpetic neuralgia (PHN), and neuropathic pain due to spinal cord injury (SCI). Approval was based on clinical trial data demonstrating statistically significant differences in pain scores versus placebo. However, statistically significant pain relief may not always equate to clinically meaningful pain relief. To further characterize the clinical benefit of pregabalin, this analysis examined shifts in pain severity categories in patients with FM, DPN/PHN (pooled in this analysis), and SCI treated with pregabalin...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27784886/diabetic-peripheral-neuropathy-and-prevalence-of-erectile-dysfunction-in-japanese-patients-aged-65-years-with-type-2-diabetes-mellitus-the-dogo-study
#13
S Furukawa, T Sakai, T Niiya, H Miyaoka, T Miyake, S Yamamoto, K Maruyama, T Ueda, H Senba, Y Todo, M Torisu, H Minami, M Onji, T Tanigawa, B Matsuura, Y Hiasa, Y Miyake
Only limited epidemiological evidence exists regarding the relationship between diabetic neuropathy and erectile dysfunction (ED) among Japanese patients with type 2 diabetes mellitus. To investigate the relationship between diabetic neuropathy and ED among Japanese patients with type 2 diabetes mellitus, a multicenter cross-sectional study was conducted in 287 male Japanese patients with type 2 diabetes mellitus, age (19-65 years). Diabetic neuropathy was diagnosed if the patients showed two or more of the following three characteristics: neuropathic symptoms, decreased or disappeared Achilles tendon reflex and/or abnormal vibration perception...
October 27, 2016: International Journal of Impotence Research
https://www.readbyqxmd.com/read/27769219/advanced-practice-pharmacists-a-retrospective-evaluation-of-the-efficacy-and-cost-of-clinical-pharmacist-practitioners-managing-ambulatory-medicare-patients-in-north-carolina-apple-nc
#14
Michèle M Kislan, Adam T Bernstein, Loretta R Fearrington, Timothy J Ives
BACKGROUND: Clinical Pharmacist Practitioners are advanced practicing pharmacists in North Carolina that provide disease-specific management. The purpose of this retrospective cohort study was to compare the efficacy and charges from referrals to a Clinical Pharmacist Practitioner by the primary care provider, to those managed by a primary care provider alone. METHODS: Patients were separated into cohorts depending if they had at least two appointments with a Clinical Pharmacist Practitioner from November 2008 to November 2011...
October 21, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27756190/comparison-of-sensory-tests-and-neuronal-quantity-of-peripheral-nerves-between-streptozotocin-stz-induced-diabetic-rats-and-paclitaxel-pac-treated-rats
#15
Heung Yong Jin, Na Young Lee, Hyun A Ko, Kyung Ae Lee, Tae Sun Park
Although diabetic peripheral neuropathy (DPN) and chemotherapy-induced peripheral neuropathy (CIPN) are different disease entities, they share similar neuropathic symptoms that impede quality of life for these patients. Despite having very similar downstream effects, there have been no direct comparisons between DPN and CIPN with respect to symptom severity and therapeutic responses. We compared peripheral nerve damage due to hyperglycemia with that caused by paclitaxel (PAC) treatment as represented by biochemical parameters, diverse sensory tests, and immunohistochemistry of cutaneous and sciatic nerves...
September 2016: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/27752287/getting-the-right-balance-insole-design-alters-the-static-balance-of-people-with-diabetes-and-neuropathy
#16
Joanne Paton, Sam Glasser, Richard Collings, Jon Marsden
BACKGROUND: Over 1 in 3 older people with diabetes sustain a fall each year. Postural instability has been identified as independent risk factor for falls within people with Diabetic Peripheral Neuropathy (DPN). People with DPN, at increased risk of falls, are routinely required to wear offloading insoles, yet the impact of these insoles on postural stability and postural control is unknown. The aim of this study was to evaluate the effect of a standard offloading insole and its constituent parts on the balance in people with DPN...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/27723381/high-prevalence-of-achilles-tendon-enthesopathic-changes-in-patients-with-type-2-diabetes-without-peripheral-neuropathy
#17
Francesco Ursini, Franco Arturi, Salvatore D'Angelo, Lewa Amara, Kassandra Nicolosi, Emilio Russo, Saverio Naty, Caterina Bruno, Giovambattista De Sarro, Ignazio Olivieri, Rosa Daniela Grembiale
BACKGROUND: Metabolic disorders are known to alter the mechanical properties of tendons. We sought to evaluate the prevalence of asymptomatic Achilles tendon enthesopathic changes in patients with type 2 diabetes mellitus (T2DM) without peripheral neuropathy. METHODS: We recruited 43 patients with T2DM and 40 controls. Neuropathy was excluded with the Michigan Neuropathy Scoring Instrument. Bilateral ultrasonography of the Achilles tendon enthesis was performed...
October 10, 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27720359/comparison-the-effects-of-two-types-of-therapeutic-exercises-frenkele-vs-swiss-ball-on-the-clinical-balance-measures-in-patients-with-type-ii-diabetic-neuropathy
#18
Zahra Rojhani-Shirazi, Fatemeh Barzintaj, Mohamad Reza Salimifard
BACKGROUND: The number of diabetic patients is increasing in the world. Peripheral neuropathy is the most important problem of diabetes. Neuropathy eventually leads to balance impairment which is the main cause of falling down in these patients However, not sufficient evidences available to compare different protocols for improving balance in diabetic patients. OBJECTIVE: This study aimed to compare the effects of two therapeutic exercises on clinical balance measures in patients with type II diabetic peripheral neuropathy...
September 15, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27716423/vitamin-b12-deficiency-in-metformin-treated-type-2-diabetes-patients-prevalence-and-association-with-peripheral-neuropathy
#19
Marwan A Ahmed, George Muntingh, Paul Rheeder
BACKGROUND: The association between long-term metformin use and low vitamin B12 levels has been proven. However, the prevalence estimates of metformin-induced vitamin B12 deficiency showed considerable variation among the studies. The potential of the deficiency to cause or worsen peripheral neuropathy in type-2 diabetes mellitus (T2DM) patients has been investigated with conflicting results. The aim of the study was to investigate: 1) the prevalence of vitamin B12 deficiency in T2DM patients on metformin; 2) the association between vitamin B12 and peripheral neuropathy; 3) and the risk factors for vitamin B12 deficiency in these patients...
October 7, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27716263/serum-bicarbonate-concentration-and-the-risk-of-cardiovascular-disease-and-death-in-type-2-diabetes-the-fremantle-diabetes-study
#20
S A Paul Chubb, Wendy A Davis, Kirsten E Peters, Timothy M E Davis
BACKGROUND: Serum bicarbonate is associated with mortality, heart failure (HF) and progression of renal failure in studies of healthy people and patients with chronic kidney disease, but the significance of these observations in unselected patients with diabetes in the general population is unknown. The aim of this study was to determine whether serum bicarbonate was associated with mortality and cardiovascular disease risk in type 2 diabetes. METHODS: Baseline serum bicarbonate was available for 1283 well-characterized community-based patients (mean ± SD age 64...
October 6, 2016: Cardiovascular Diabetology
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