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https://www.readbyqxmd.com/read/28544202/breaking-up-sedentary-time-with-seated-upper-body-activity-can-regulate-metabolic-health-in-obese-high-risk-adults-a-randomised-crossover-trial
#1
Matthew McCarthy, Charlotte L Edwardson, Melanie J Davies, Joseph Henson, Alex Rowlands, James King, Danielle H Bodicoat, Kamlesh Khunti, Thomas Yates
AIMS: To investigate the impact of performing short bouts of seated upper body activity on postprandial blood glucose and insulin levels during prolonged sitting. MATERIALS AND METHODS: Participants undertook two 7 · 5 hour experimental conditions in a randomised order: 1) prolonged sitting only 2) sitting interspersed with 5 minutes of seated arm ergometry every 30 minutes. Blood samples were obtained while fasting and throughout the postprandial period following ingestion of two standardised meals...
May 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28544064/obesity-is-inversely-related-to-the-risks-of-dental-caries-in-korean-adults
#2
In-Seok Song, Kyungdo Han, Jae-Jun Ryu, Jun-Beom Park
OBJECTIVE: This study investigated whether obesity is linked with dental caries. The present study hypothesized that obesity may influence the number or prevalence of dental caries in Korean adults. SUBJECTS AND METHODS: Data was derived from Korea National Health and Nutrition Examination Survey performed at 2008-2010. Lifestyle, sociodemographic, and biochemical variables were analyzed. Indices related with obesity, sarcopenia, and metabolic syndrome were investigated...
May 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28543830/weight-change-obesity-and-risk-of-prostate-cancer-progression-among-men-with-clinically-localized-prostate-cancer
#3
Barbra A Dickerman, Thomas U Ahearn, Edward Giovannucci, Meir J Stampfer, Paul L Nguyen, Lorelei A Mucci, Kathryn M Wilson
Obesity is associated with an increased risk of fatal prostate cancer. We aimed to elucidate the relevant timing and importance of obesity and weight change for prostate cancer progression. We identified 5,158 men diagnosed with localized prostate cancer (clinical stage T1/T2) from 1986-2012 in the Health Professionals Follow-up Study. Men were followed for biochemical recurrence and lethal prostate cancer (development of distant metastasis or prostate cancer-specific mortality) until 2012. Cox regression estimated hazard ratios (HRs) for body mass index (BMI) at age 21, BMI at diagnosis, "long-term" weight change from age 21 to diagnosis, and "short-term" weight change over spans of 4 and 8 years preceding diagnosis...
May 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28542544/development-and-characterization-of-an-experimental-model-of-diet-induced-metabolic-syndrome-in-rabbit
#4
Oscar Julián Arias-Mutis, Vannina G Marrachelli, Amparo Ruiz-Saurí, Antonio Alberola, Jose Manuel Morales, Luis Such-Miquel, Daniel Monleon, Francisco J Chorro, Luis Such, Manuel Zarzoso
Metabolic syndrome (MetS) has become one of the main concerns for public health because of its link to cardiovascular disease. Murine models have been used to study the effect of MetS on the cardiovascular system, but they have limitations for studying cardiac electrophysiology. In contrast, the rabbit cardiac electrophysiology is similar to human, but a detailed characterization of the different components of MetS in this animal is still needed. Our objective was to develop and characterize a diet-induced experimental model of MetS that allows the study of cardiovascular remodeling and arrhythmogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28541730/results-of-a-metabolic-health-clinic-at-a-hostel-for-homeless-men
#5
Olav Nielssen, Alan Chudleigh, Mia Chen, Matthew Large, Tania Markovic, Lucy Cooper
OBJECTIVES: People who are homeless have high mortality and morbidity, including from metabolic disorder. The aim of this study was to report on the characteristics and progress of the metabolic health of people attending a metabolic clinic at a homeless men's shelter. METHODS: Homeless men attending the clinic were assessed by measuring their weight, height, body mass index (BMI), waist circumference, blood pressure, blood lipids, fasting blood glucose and, if indicated, HbA1c...
June 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28540690/microrna-regulatory-networks-as-biomarkers-in-obesity-the-emerging-role
#6
Lihua Zhang, Daniel Miller, Qiuping Yang, Bin Wu
Even though it is a pandemic health problem worldwide, the pathogenesis of obesity is poorly understood. Recently, emerging studies verified that microRNAs (miRNAs) are involved in complicated metabolic processes including adipocyte differentiation, fat cell formation (adipogenesis), obesity-related insulin resistance and inflammation. Many regulatory networks have been identified in murine adipose tissue, but those in human adipose tissue are not as well known. In addition, miRNAs have been detected in circulation, and thus may be usable as diagnostic indicators...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28540644/the-epigenetic-machinery-in-vascular-dysfunction-and-hypertension
#7
REVIEW
Emile Levy, Schohraya Spahis, Jean-Luc Bigras, Edgard Delvin, Jean-Michel Borys
Hypertension (HT) is among the major components of the metabolic syndrome, i.e., obesity, dyslipidemia, and hyperglycemia/insulin resistance. It represents a significant health problem with foremost risks for chronic cardiovascular disease and a significant cause of morbidity and mortality worldwide. Therefore, it is not surprising that this disorder constitutes a serious public health concern. Although multiple studies have stressed the multifactorial nature of HT, the pathogenesis remains largely unknown...
June 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28540432/central-overweight-and-obesity-in-polish-schoolchildren-aged-7-18%C3%A2-years-secular-changes-of-waist-circumference-between-1966-and-2012
#8
Agnieszka Suder, Aleksandra Gomula, Slawomir Koziel
We investigated secular trends of body mass index (BMI) and waist circumference (WC) in Polish schoolchildren examined through a period of almost 50 years. Data on height, weight and WC came from four cross-sectional surveys conducted in Poland between 1966 and 2012, covering 34,005 boys and 34,008 girls. Raw data of BMI and WC were standardized for age classes. Statistical analyses included the Kruskal-Willis test and Pearson Chi-square test. BMI and WC increased during the studied period; however, the growth was higher for WC (increase by 0...
May 24, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28540059/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#9
EDITORIAL
Csaba P Kovesdy, Susan L Furth, Carmine Zoccali
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long term...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28538842/-diagnostic-concordance-between-seven-definitions-of-metabolic-syndrome-in-overweight-and-obese-adults
#10
Eduardo Cabrera-Rode, Beatriz Stusser, Wenny Cálix, Neraldo Orlandi, Janet Rodríguez, Ileana Cubas-Dueñas, Ragmila Echevarría, Aimee Álvarez
Objectives: The aim of this study was to determine the level of diagnostic concordance between seven definitions of metabolic syndrome (MS) in a group of overweight and obese adults. Materials and Methods: 350 subjects aged from 19 to 70 years were recruited for study from a clinic for overweight and obese subjects. The definitions of MS used were those given by the WHO (World Health Organization), EGIR (European Group for the Study of Insulin Resistance), NCEP- ATPIII (Adult Treatment Panel), AHA/NHLBI (American Heart Association), IDF (International Diabetes Federation), and JIS (Joint Interim Statement) as well as the Szabo criteria...
January 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28538182/targeting-metabolic-reprogramming-by-influenza-infection-for-therapeutic-intervention
#11
Heather S Smallwood, Susu Duan, Marie Morfouace, Svetlana Rezinciuc, Barry L Shulkin, Anang Shelat, Erika E Zink, Sandra Milasta, Resha Bajracharya, Ajayi J Oluwaseum, Martine F Roussel, Douglas R Green, Ljiljana Pasa-Tolic, Paul G Thomas
Influenza is a worldwide health and financial burden posing a significant risk to the immune-compromised, obese, diabetic, elderly, and pediatric populations. We identified increases in glucose metabolism in the lungs of pediatric patients infected with respiratory pathogens. Using quantitative mass spectrometry, we found metabolic changes occurring after influenza infection in primary human respiratory cells and validated infection-associated increases in c-Myc, glycolysis, and glutaminolysis. We confirmed these findings with a metabolic drug screen that identified the PI3K/mTOR inhibitor BEZ235 as a regulator of infectious virus production...
May 23, 2017: Cell Reports
https://www.readbyqxmd.com/read/28537332/comparison-of-intermittent-fasting-versus-caloric-restriction-in-obese-subjects-a-two-year-follow-up
#12
F B Aksungar, M Sarıkaya, A Coskun, M Serteser, I Unsal
OBJECTIVE: Caloric restriction (CR) is proven to be effective in increasing life span and it is well known that, nutritional habits, sleeping pattern and meal frequency have profound effects on human health. In Ramadan some Muslims fast during the day-light hours for a month, providing us a unique model of intermittent fasting (IF) in humans. In the present study, we have investigated the effects of IF versus CR on the same non-diabetic obese subjects who were followed for two years according to the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28533263/prior-weight-loss-exacerbates-the-biological-drive-to-gain-weight-after-the-loss-of-ovarian-function
#13
Vanessa D Sherk, Matthew R Jackman, Erin D Giles, Janine A Higgins, Rebecca M Foright, David M Presby, Ginger C Johnson, Julie A Houck, Jordan L Houser, Robera Oljira, Paul S MacLean
Both the history of obesity and weight loss may change how menopause affects metabolic health. The purpose was to determine whether obesity and/or weight loss status alters energy balance (EB) and subsequent weight gain after the loss of ovarian function. Female lean and obese Wistar rats were randomized to 15% weight loss (WL) or ad libitum fed controls (CON). After the weight loss period, WL rats were kept in EB at the reduced weight for 8 weeks prior to ovariectomy (OVX). After OVX, all rats were allowed to eat ad libitum until weight plateaued...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28529329/body-mass-index-growth-trajectories-associated-with-the-different-parameters-of-the-metabolic-syndrome-at-adulthood
#14
K V Giudici, M-F Rolland-Cachera, G Gusto, D Goxe, O Lantieri, S Hercberg, S Péneau
BACKGROUND: Growth trajectories have shown to be related to obesity and metabolic risks in later life, however body mass index (BMI) trajectories according to the presence or absence of metabolic syndrome (MS) and its parameters in adulthood are scarce in literature. OBJECTIVES: To investigate BMI trajectories during childhood in relation to MS and its parameters in adult age. METHODS: A total of 1919 subjects (43.4% male, 20-60y) participated in this retrospective cohort study...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28529179/mitochondria-and-endoplasmic-reticulum-targets-for-a-better-insulin-sensitivity-in-skeletal-muscle
#15
REVIEW
Alexis Boulinguiez, Bart Staels, Helene Duez, Steve Lancel
Obesity and its associated metabolic disorders represent a major health burden, with economic and social consequences. Although adapted lifestyle and bariatric surgery are effective in reducing body weight, obesity prevalence is still rising. Obese individuals often become insulin-resistant. Obesity impacts on insulin responsive organs, such as the liver, adipose tissue and skeletal muscle, and increases the risk of cardiovascular diseases, type 2 diabetes and cancer. In this review, we discuss the effects of obesity and insulin resistance on skeletal muscle, an important organ for the control of postprandial glucose...
May 18, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28526378/association-between-prepregnancy-obesity-and-metabolic-risk-in-chilean-premenopausal-women-10%C3%A2-y-postpartum
#16
Maria Luisa Garmendia, Carolina Zamudio, Marcela Araya, Juliana Kain
OBJECTIVES: One of every four pregnant women in Chile is obese. Gestational obesity is associated with maternal metabolic complications in pregnancy (e.g., gestational diabetes, preeclampsia), but to our knowledge, there is little evidence on relationships with future metabolic risk. The aim of this study was to evaluate the association between prepregnancy obesity (prepregnancy body mass index ≥30 kg/m(2)) or excessive gestational weight gain (GWG; according to the 2009 recommendations from the Institute of Medicine), and maternal metabolic complications 10 y postpartum in premenopausal Chilean women...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526377/orange-juice-allied-to-a-reduced-calorie-diet-results-in-weight-loss-and-ameliorates-obesity-related-biomarkers-a-randomized-controlled-trial
#17
Carolina Ribeiro, Grace Dourado, Thais Cesar
OBJECTIVE: Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals. METHODS: A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m(2)) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526006/cardiometabolic-profile-of-obese-children-in-a-sub-saharan-african-setting-a-cross-sectional-study
#18
Eunice Chedjou-Nono, Suzanne Sap, Simeon-Pierre Choukem, Issa Ngosso Tetanye, Daniel Nebongo, Olivier Koki Ndombo
BACKGROUND: Cardiovascular and metabolic consequences of obesity in children, unlike adults, are still not well understood nor have they been subject to extensive research in Africa. We aimed to identify the cardio-metabolic complications associated with childhood obesity at the early phase of the management of obese children in a reference center in Cameroon. METHODS: In this cross-sectional study conducted from November 2013 to September 2014 and based on World Health Organization (WHO) classification of Obesity (BMI > 3SD under 5 years and BMI > 2SD from 5 and above), we included children aged 3 to 17 years who were being followed up for obesity at the pediatric endocrinology unit of the Mother and Child Center of the Chantal BIYA Foundation in Yaounde, Cameroon...
May 19, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28521687/diet-and-contaminants-driving-the-rise-to-obesity-epidemics
#19
Agostino Di Ciaula, Piero Portincasa
The obesity epidemic is spreading worldwide without reversal trend and despite specific policies oriented to dietary habits and lifestyle, which seem to have modest effects. Genetic factors only partly explain the rise, whereas environmental factors seem to play a key role, mainly by gene-environment interactions through epigenetic mechanisms. A number of animal and human studies point to maternal diet, intestinal microbiota and chemicals introduced as contaminants with food, all factors able to increase the risk of obesity...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28521681/effects-of-diets-on-adipose-tissue
#20
Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa, Gema Frühbeck
Obesity is a major health problem that has become a global epidemic. Overweight and obesity are commonly associated with the development of several pathologies, such as insulin resistance, cardiovascular diseases, sleep apnea and several types of cancer, which can lead to further morbidity and mortality. An increased abdominal adiposity renders overweight and obese individuals more prone to metabolic and cardiovascular problems. In this sense, excess adiposity leads to several changes in the biology, morphology and function of the adipose tissue, such as adipocyte hypertrophy and hyperplasia, adipose tissue inflammation and fibrosis and an impaired secretion of adipokines, contributing to the onset of obesity-related co-morbidities...
May 17, 2017: Current Medicinal Chemistry
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