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https://www.readbyqxmd.com/read/29228352/tumour-necrosis-factor-alpha-in-uraemic-serum-promotes-osteoblastic-transition-and-calcification-of-vascular-smooth-muscle-cells-via-extracellular-signal-regulated-kinases-and-activator-protein-1-c-fos-mediated-induction-of-interleukin-6-expression
#1
Daniel Zickler, Christian Luecht, Kevin Willy, Lei Chen, Janusz Witowski, Matthias Girndt, Roman Fiedler, Markus Storr, Julian Kamhieh-Milz, Janosch Schoon, Sven Geissler, Olle Ringdén, Ralf Schindler, Guido Moll, Duska Dragun, Rusan Catar
Background: Vascular calcification is enhanced in uraemic chronic haemodialysis patients, likely due to the accumulation of midsize uraemic toxins, such as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Here we have assessed the impact of uraemia on vascular smooth muscle cell (VSMC) calcification and examined the role of IL-6 and TNF-α as possible mediators and, most importantly, its underlying signalling pathway in VSMCs. Methods: VSMCs were incubated with samples of uraemic serum obtained from patients treated with haemodialysis for renal failure in the Permeability Enhancement to Reduce Chronic Inflammation-I clinical trial...
December 8, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29226133/circulating-interferon-%C3%AE-3-responsiveness-to-hbv-vaccination-and-hbv-hcv-infections-in-haemodialysis-patients
#2
Alicja E Grzegorzewska, Monika K Świderska, Adrianna Mostowska, Paweł P Jagodziński
The IFN-λ3 gene (IFNL3) plays a role in HCV clearance. We investigated circulating IFN-λ3 and IFNL3 SNPs in haemodialysis patients who differed in their response to HBV vaccination and their HBV/HCV infection status. In 201 patients, plasma IFN-λ3 was determined using ELISA. IFNL3 SNPs (rs12979860, rs8099917) were genotyped using HRM analysis. Differences in IFN-λ3 levels were shown between responders and nonresponders to HBV vaccination and between HBsAg-positive patients and those who developed anti-HBs after infection and became HBsAg negative...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225812/the-utility-of-whole-body-vibration-exercise-in-haemodialysis-patients-a-pilot-study
#3
Arthur Doyle, Karen Chalmers, David J Chinn, Fiona McNeill, Nicola Dall, Christopher H Grant
Background: Exercise improves physical capacity in patients with end-stage renal disease on haemodialysis (HD), but few patients engage in it. Whole-body vibration exercise (WBVE) is a novel protocol that has been shown to benefit frail elderly patients' rehabilitation. We assessed the utility of WBVE before HD sessions and tested methods to inform the design of a randomized controlled trial (RCT). Methods: Physical condition and quality of life were assessed at enrolment and repeated 2 weeks later in a pilot study of 49 patients undergoing regular HD...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225811/regular-exercise-during-haemodialysis-promotes-an-anti-inflammatory-leucocyte-profile
#4
Maurice Dungey, Hannah M L Young, Darren R Churchward, James O Burton, Alice C Smith, Nicolette C Bishop
Background: Cardiovascular disease is the most common cause of mortality in haemodialysis (HD) patients and is highly predicted by markers of chronic inflammation. Regular exercise may have beneficial anti-inflammatory effects, but this is unclear in HD patients. This study assessed the effect of regular intradialytic exercise on soluble inflammatory factors and inflammatory leucocyte phenotypes. Methods: Twenty-two HD patients from a centre where intradialytic cycling was offered thrice weekly and 16 HD patients receiving usual care volunteered...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29217095/sofosbuvir-plus-daclatasvir-as-an-alternative-for-patients-on-haemodialysis-with-genotype-2-hepatitis-c-virus-infection
#5
Jara Llenas-García, Sergio Padilla, Mar Masiá, Félix Gutiérrez
No abstract text is available yet for this article.
December 4, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29207754/clinicopathological-characteristics-and-outcomes-of-diffuse-crescentic-glomerulonephritis-a-single-center-experience-from-southern-india
#6
Shankar Prasad Nagaraju, Sindhura Lakshmi Koulmane Laxminarayana, Srinivas Kosuru, Rajeevalochana Parthasarathy, Ravindra Prabhu Attur, Dharshan Rangaswamy, Uday Venkat Matteti, Vasudeva Guddattu
Introduction: Diffuse Crescentic glomerulonephritis (CrGN) is characterized by rapidly progressive renal failure and has grave prognosis. There is significant regional and temporal variation in aetiology, prevalence and prognosis of diffuse crescentic glomerulonephritis (CrGN) with limited data available in adult Indian population. Aim: This study aims to identify the aetiology, clinico-pathological features and outcomes of diffuse CrGN in south Indian population...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29199769/peritoneal-dialysis-for-acute-kidney-injury
#7
REVIEW
Linfeng Liu, Ling Zhang, Guan J Liu, Ping Fu
BACKGROUND: Peritoneal dialysis (PD) has been suggested as an effective and safe dialysis modality in patients with acute kidney injury (AKI). However, whether PD is superior to extracorporeal therapy (e.g. haemodialysis) in terms of improving survival, recovery of kidney function, metabolic and clinical outcomes is still inconclusive. OBJECTIVES: The aim of this review was to evaluate the benefits and harms of PD for patients with AKI compared with extracorporeal therapy or different PD modalities...
December 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29199277/the-renaissance-of-complement-therapeutics
#8
REVIEW
Daniel Ricklin, Dimitrios C Mastellos, Edimara S Reis, John D Lambris
The increasing number of clinical conditions that involve a pathological contribution from the complement system - many of which affect the kidneys - has spurred a regained interest in therapeutic options to modulate this host defence pathway. Molecular insight, technological advances, and the first decade of clinical experience with the complement-specific drug eculizumab, have contributed to a growing confidence in therapeutic complement inhibition. More than 20 candidate drugs that target various stages of the complement cascade are currently being evaluated in clinical trials, and additional agents are in preclinical development...
December 4, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29198593/a-new-generation-of-cellulose-triacetate-suitable-for-online-haemodiafiltration
#9
Francisco Maduell, Raquel Ojeda, Marta Arias-Guillén, Néstor Fontseré, Manel Vera, Lida Rodas, Miquel Gómez, Karen P Huablocho, Fanny Esquivel, Paola D Mori, Valentina Hoffmann, Jessica Ugalde, Nayra Rico
BACKGROUND: Online haemodiafiltration (OL-HDF) is currently the most effective dialysis technique that also improves survival. To date, high permeability membranes with low albumin loss, such as polysulfone, polyamide and polyacrylonitrile membranes have been the most widely used. However, the initially restricted use of cellulose triacetate (CTA) membranes in OL-HDF has expanded. The aim of the study was to ascertain whether the latest generation asymmetric CTA membranes are more effective in obtaining high convective transport...
November 29, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29198453/effects-of-rotigotine-on-clinical-symptoms-quality-of-life-and-sleep-hygiene-adequacy-in-haemodialysis-associated-restless-legs-syndrome
#10
Vicent Esteve, Jose Carneiro, Gabriel Salazar, Mónica Pou, Irati Tapia, Miquel Fulquet, Verónica Duarte, Anna Saurina, Fátima Moreno, Manel Ramírez de Arellano
BACKGROUND: Restless legs syndrome (RLS) is a neurological disorder characterised by bothersome symptoms associated with impaired quality of life and sleep hygiene. Rotigotine is a novel therapeutic alternative, although few studies have been published in patients on haemodialysis (HD) with RLS treated with rotigotine. OBJECTIVES: 1.- To establish the prevalence of RLS in our HD unit. 2.- To evaluate the efficacy and safety profile of rotigotine and its effect on symptoms, quality of life and sleep hygiene in our HD population with RLS...
November 30, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29198413/is-carotid-revascularization-worthwhile-in-patients-waiting-for-kidney-transplantation
#11
REVIEW
Peter Balaz, Petrut Gogalniceanu, Chris Callaghan
Renal failure and haemodialysis are associated with an increased risk of cardiovascular disease. Patients undergoing renal transplantation undergo rigorous pre-operative vascular assessment, including optimisation of risk factors for stroke. The indication for carotid intervention and the threshold for carotid endarterectomy in asymptomatic patients with incidental carotid disease has not been clarified in the context chronic kidney disease (CKD). This review aims to analyse outcomes following carotid endarterectomy in patients with CKD, in order to ascertain whether general guidelines for carotid artery revascularisation apply to this specific cohort...
November 16, 2017: Transplantation Reviews
https://www.readbyqxmd.com/read/29198062/an-evaluation-of-four-modes-of-low-dose-anticoagulation-during-intermittent-haemodialysis
#12
Malin S E Skagerlind, Bernd G Stegmayr
INTRODUCTION: Intensive care participants that need dialysis frequently suffer from increased risk of bleeding. Standard intermittent haemodialysis (SHD) includes anticoagulation to avoid clotting of the dialysis system. The aim of this study was to clarify which of four different low-dose anticoagulant modes was preferable in reducing the exposure to i.v. unfractionated heparin (heparin) and maintaining patency of the dialysis circuit. METHODS: Twenty-three patients on SHD were included to perform haemodialysis with four modes of low-dose anticoagulation...
December 2, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29193511/epidemiology-of-haemodialysis-patients-and-haemodialysis-performance-in-nauru
#13
Chia-Tien Hsu, Richard Leona, Ming-Ju Wu
AIM: There is limited literature on haemodialysis in island countries in the Central Pacific. The primary aim of this study was to report on the epidemiology of haemodialysis patients and haemodialysis performance in Nauru. METHODS: We obtained registry data from the haemodialysis unit in Nauru to calculate the incidence rate, prevalence, and survival probability of haemodialysis patients in Nauru. We also reviewed medical records from January 2015 to February 2017 to evaluate the haemodialysis performance in Nauru...
November 28, 2017: Nephrology
https://www.readbyqxmd.com/read/29192721/haemodialysis-vascular-access-current-practices-amongst-indian-nephrologists
#14
Dinesh Bansal, Vijay Kher, Krishan Lal Gupta, Debasish Banerjee, Vivekanand Jha
INTRODUCTION: Despite the growing number of haemodialysis (HD) patients in India, little is known about vascular access practice. We investigated the use and cost of different vascular accesses by Indian nephrologists. METHODS: An online survey was emailed to 920 Indian nephrologists and 388 (42.1%) responded; 98.5% of whom were responsible for managing dialysis patients, 98% in hospitals. RESULTS: Sixty-four percent of patients initiated renal replacement therapy with HD, 7% with peritoneal dialysis, 10% kidney transplantation and 19% conservative care...
November 25, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29190613/n-terminal-prohormone-of-brain-natriuretic-peptide-but-not-c-terminal-pre-pro-vasopressin-copeptin-level-is-associated-with-the-response-to-antihypertensive-therapy-in-haemodialysis-patients
#15
Katarzyna Wyskida, Joanna Ficek, Rafał Ficek, Dagmara Adamska, Patrycja Jędrzejowska, Jarosław Wajda, Dariusz Klein, Joanna Witkowicz, Sylwia Rotkegel, Urszula Spiechowicz-Zatoń, Joanna Kocemba-Dyczek, Jarosław Ciepał, Andrzej Więcek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
BACKGROUND/AIMS: Volume overload, frequently clinically asymptomatic is considered as a causative factor limiting the effectiveness of antihypertensive therapy in haemodialysis (HD) patients. Therefore, the aim of this study was to assess plasma levels of N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) and a C-terminal portion of the precursor of vasopressin (CT-proAVP, copeptin), surrogate markers of volume overload in HD patients in relation to the number of antihypertensive drugs used in the hypertension treatment...
November 30, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29178891/rationale-and-design-for-sharehd-a-quality-improvement-collaborative-to-scale-up-shared-haemodialysis-care-for-patients-on-centre-based-haemodialysis
#16
James Fotheringham, Tania Barnes, Louese Dunn, Sonia Lee, Steven Ariss, Tracey Young, Stephen J Walters, Paul Laboi, Andy Henwood, Rachel Gair, Martin Wilkie
BACKGROUND: The study objective is to assess the effectiveness and economic impact of a structured programme to support patient involvement in centre-based haemodialysis and to understand what works for whom in what circumstances and why. It implements a program of Shared Haemodialysis Care (SHC) that aims to improve experience and outcomes for those who are treated with centre-based haemodialysis, and give more patients the confidence to dialyse independently both at centres and at home...
November 24, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29178879/residual-renal-function-in-chronic-dialysis-is-not-associated-with-reduced-erythropoietin-stimulating-agent-dose-requirements-a-cross-sectional-study
#17
Elizabeth Helene Louw, Mogamat-Yazied Chothia
BACKGROUND: Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is associated with a reduction in ESA resistance and mortality in chronic dialysis. The primary aim was to establish whether RRF has an association with ESA dose requirements in ESKD patients receiving chronic dialysis. METHODS: A single center, cross-sectional study involving 100 chronic dialysis patients was conducted from December 2015 to May 2016...
November 25, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29166338/use-of-organs-from-hepatitis-c-virus-positive-donors-for-uninfected-recipients-a-potential-cost-effective-approach-to-save-lives
#18
Patrick B Trotter, Dominic M Summers, Ines Ushiro-Lumb, Matthew Robb, J Andrew Bradley, James Powell, Christopher J E Watson, James Neuberger
BACKGROUND: Organs from hepatitis C virus (HCV) seropositive (HCVpos) individuals are seldom used for transplantation because of the risk of disease transmission. Because transmitted HCV is now amenable to effective treatment we estimated the potential impact of using HCVpos deceased donor organs for transplantation. METHODS: The Potential Donor Audit (PDA) of patients (<80years) dying in UK critical care units and the UK Transplant Registry (UKTR) was searched to identify HCVpos potential and proceeding deceased donors...
November 22, 2017: Transplantation
https://www.readbyqxmd.com/read/29148006/autogenous-forearm-loop-arteriovenous-fistula-creation
#19
Weng Jun Tang, Arman Zaharil Mat Saad
INTRODUCTION: Arteriovenous fistula is a lifeline for end-stage kidney disease patients on dialysis. The quality of the vein and artery to be used plays a crucial role in attaining a functioning, reliable and long-lasting arteriovenous fistula. The aim of the study is to present an alternative for haemodialysis access to preserve the upper arm vasculature for future use - the forearm loop arteriovenous fistula. METHODS: From October 2015 to September 2016, 202 patients with chronic kidney disease (CKD), stages 4 and 5, underwent arteriovenous fistula creation at the Universiti Sains Malaysia Hospital, Malaysia...
November 13, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/29148005/microsurgery-for-wrist-arteriovenous-fistula-creation-in-children-a-retrospective-cohort-study
#20
Afram Akturk, Roel Bakx, Michiel J S Oosterveld, Jim C H Wilde, Mirza M Idu
INTRODUCTION: Creating functional arteriovenous fistulae (AVF) at the wrist is challenging in paediatric patients because of the small calibre of the blood vessels. METHODS: We report our experience with AVF surgery in children younger than 15 years of age using microsurgical techniques. Twenty-five patients underwent AVF surgery between 2003 and 2015 (20 for haemodialysis, 4 for plasmapheresis and 1 for parenteral nutrition). Median (range) age was 9 (2-15) years and median weight was 24 (8-61) kg...
November 13, 2017: Journal of Vascular Access
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