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https://www.readbyqxmd.com/read/29447408/survival-advantage-of-planned-haemodialysis-over-peritoneal-dialysis-a-cohort-study
#1
Alicia Thiery, François Séverac, Thierry Hannedouche, Cecile Couchoud, Van Huyen Do, Aurélien Tiple, Clémence Béchade, Erik-Andre Sauleau, Thierry Krummel
Background: Previous studies comparing the outcomes in haemodialysis (HD) with those in peritoneal dialysis (PD) have yielded conflicting results. Methods: The aim of the study was to compare the survival of planned HD versus PD patients in a cohort of adult incident patients who started renal replacement therapy (RRT) between 2006 and 2008 in the nationwide REIN registry (Réseau Epidémiologie et Information en Néphrologie). Patients who started RRT in emergency or stopped RRT within 2 months were excluded...
February 13, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29446172/measuring-the-prevalence-of-intradialytic-hypotension-in-a-satellite-dialysis-clinic-are-we-too-complacent
#2
Ulrich Steinwandel, Nick Gibson, Mandy Towell, Richard Parsons, James Rippey, Johan Rosman
AIMS AND OBJECTIVES: Measuring the prevalence of symptomatic (S-IDH) and asymptomatic intradialytic hypotension (A-IDH) or post-dialysis overhydration in a satellite haemodialysis clinic in Western Australia. BACKGROUND: Intradialytic hypotension is one of the most common side-effects of haemodialysis caused by ultrafiltration provoking a temporary volume depletion. The prevalence of asymptomatic hypotension during dialysis has been rarely reported, but is considered to have the same negative consequences as symptomatic hypotension on various end organs like the brain and the gastro-intestinal tract...
February 15, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29445225/atrial-fibrillation-characteristics-in-patients-on-haemodialysis-vs-peritoneal-dialysis
#3
Ran Abuhasira, Yuval Mizrakli, Avi Shimony, Victor Novack, Alla Shnaider, Yosef S Haviv
Atrial fibrillation (AF) is highly prevalent in dialysis patients, however whether its impact differs between patients on haemodialysis (HD) vs. peritoneal dialysis (PD) is unknown. We aimed to compare the association of AF and clinical outcomes in different dialysis modalities. We performed a population based retrospective cohort study, including adult patients who initiated dialysis between the years 2002 and 2015. Clinical, echocardiographic and laboratory data were reviewed and correlated with outcomes in HD vs...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444222/extracorporeal-membrane-oxygenation-as-a-bridge-to-lung-transplantation-may-not-impact-overall-mortality-risk-after-transplantation-results-from-a-7-year-single-centre-experience
#4
Fabio Ius, Ruslan Natanov, Jawad Salman, Christian Kuehn, Wiebke Sommer, Murat Avsar, Thierry Siemeni, Dmitry Bobylev, Reza Poyanmehr, Dietmar Boethig, Joerg Optenhoefel, Nicolaus Schwerk, Axel Haverich, Gregor Warnecke, Igor Tudorache
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has an important role in bridging patients to lung transplantation. In this study, we present our experience with pretransplant ECMO during the last 7 years and investigate its impact on graft outcomes. METHODS: Records of all lung-transplanted patients at our institution between January 2010 and April 2017 were retrospectively reviewed. Graft survival was compared between patients who required pretransplant ECMO (pre-Tx ECMO+) and patients who did not (pre-Tx ECMO-)...
February 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29441494/cost-minimisation-analysis-of-erythropoiesis-stimulating-agents-in-the-treatment-of-anaemia-in-dialysed-patients-a-pilot-study
#5
Astrid Darsonval, Virginie Besson, Claire Cavalin
OBJECTIVE: This study aimed to assess the cost impact of administering erythropoiesis-stimulating agents once every 4 weeks instead of one to three times a week to treat anaemia in patients undergoing dialysis. METHODS: This was a monocentric retrospective study involving 27 patients who underwent haemodialysis between 2009 and 2013 in a university hospital in Angers, France. The study was a cost-minimisation analysis from the hospital perspective. Only direct medical costs were considered...
September 2017: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29439674/establishing-a-clinical-phenotype-for-cachexia-in-end-stage-kidney-disease-study-protocol
#6
Joanne Reid, Helen R Noble, Gary Adamson, Andrew Davenport, Ken Farrington, Denis Fouque, Kamyar Kalantar-Zadeh, John Mallett, C McKeaveney, S Porter, David S Seres, Joanne Shields, Adrian Slee, Miles D Witham, Alexander P Maxwell
BACKGROUND: Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some evidence of muscle wasting. ESKD is associated with an increase in inflammatory cytokines and can result in cachexia, with the loss of muscle and fat stores. At present, only limited data are available on the classification of wasting experienced by persons with ESKD...
February 13, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29424935/the-effect-of-extended-hours-dialysis-on-sleep-quality-in-a-randomised-trial
#7
Jin-Lan Liao, Oliver van den Broek-Best, Brendan Smyth, Daqing Hong, Kha Vo, Li Zuo, Nicholas A Gray, Christopher T Chan, Janak de Zoysa, Vlado Perkovic, Lei Jiang, Meg Jardine
BACKGROUND: Poor sleep quality is common in haemodialysis patients and associated with worse outcomes. In this pre-specified analysis, we examined the impact of extended hours haemodialysis on sleep quality. METHODS: The ACTIVE Dialysis trial randomized 200 participants to extended (≥24 hours/week) or standard (target 12-15 hours) hours haemodialysis over 12 months. Sleep quality was measured in the Kidney Disease Quality of Life Short Form 1.3 (KDQOL-SF) by overall sleep quality score (0-10, 10 = "very good") and the sleep subscale (0-100, 100 = 'best possible sleep') every three months via blinded telephone interviewer...
February 9, 2018: Nephrology
https://www.readbyqxmd.com/read/29423210/the-european-renal-association-european-dialysis-and-transplant-association-era-edta-registry-annual-report-2015-a-summary
#8
Anneke Kramer, Maria Pippias, Marlies Noordzij, Vianda S Stel, Nikolaos Afentakis, Patrice M Ambühl, Anton M Andrusev, Emma Arcos Fuster, Federico E Arribas Monzón, Anders Åsberg, Myftar Barbullushi, Marjolein Bonthuis, Fergus J Caskey, Pablo Castro de la Nuez, Harijs Cernevskis, Jean-Marin des Grottes, Liliana Garneata, Eliezer Golan, Marc H Hemmelder, Kyriakos Ioannou, Faical Jarraya, Mykola Kolesnyk, Kirill Komissarov, Mathilde Lassalle, Fernando Macario, Beatriz Mahillo-Duran, Angel L Martín de Francisco, Runolfur Palsson, Ülle Pechter, Halima Resic, Boleslaw Rutkowski, Carmen Santiuste de Pablos, Nurhan Seyahi, Sanja Simic Ogrizovic, María F Slon Roblero, Viera Spustova, Olivera Stojceva-Taneva, Jamie Traynor, Ziad A Massy, Kitty J Jager
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry's 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2015 within 36 countries. Methods: In 2016 and 2017, the ERA-EDTA Registry received data on patients who were undergoing RRT for ESRD in 2015, from 52 national or regional renal registries. Thirty-two registries provided individual patient-level data and 20 provided aggregated-level data...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423207/old-and-new-calcimimetics-for-treatment-of-secondary-hyperparathyroidism-impact-on-biochemical-and-relevant-clinical-outcomes
#9
Luciano Pereira, Catarina Meng, Daniela Marques, João M Frazão
Secondary hyperparathyroidism (SHPT) is associated with increased bone turnover, risk of fractures, vascular calcifications, and cardiovascular and all-cause mortality. The classical treatment for SHPT includes active vitamin D compounds and phosphate binders. However, achieving the optimal laboratory targets is often difficult because vitamin D sterols suppress parathyroid hormone (PTH) secretion, while also promoting calcium and phosphate intestinal absorption. Calcimimetics increase the sensitivity of the calcium-sensing receptor, so that even with lower levels of extracellular calcium a signal can still exist, leading to a decrease of the set-point for systemic calcium homeostasis...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423206/achievement-of-kidney-disease-improving-global-outcomes-mineral-and-bone-targets-between-2010-and-2014-in-incident-dialysis-patients-in-france-the-photo-graphe3-study
#10
Denis Fouque, Hubert Roth, Bernadette Darné, Louis Jean-Bouchet, Eric Daugas, Tilman B Drüeke, Thierry Hannedouche, Guillaume Jean, Gérard M London
Background: Abnormal serum phosphate, calcium and parathyroid hormone (PTH) levels in patients with chronic kidney disease (CKD) undergoing haemodialysis have been associated with poor survival. The French Phosphorus and Calcium Observatory (Photo-Graphe ® 3) aimed to estimate the percentage of CKD patients achieving the three Kidney Disease: Improving Global Outcomes (KDIGO) targets about optimal serum phosphate, calcium and PTH over a 3.5-year follow-up period. Methods: This was a prospective, multicentre, epidemiological observational study conducted with nephrologists in France, selected using a clustering approach...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29423205/ckd-mbd-kdigo-guidelines-how-difficult-is-reaching-the-target
#11
Mario Cozzolino
Patients with chronic kidney disease (CKD) are affected by mineral and bone disorder (MBD), resulting in abnormalities in serum calcium (Ca), phosphorous (P) and parathyroid hormone (PTH). Changes in mineral metabolism have also been associated with higher rates of both all-cause and cardiovascular-related mortality. The majority of haemodialysis patients are also deficient in the endogenous hormone 1,25-dihydroxyvitamin D (calcitriol), often contributing to increased secondary hyperparathyroidism (SHPT) and consequently to abnormal levels of Ca, P and PTH...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29422155/the-effect-of-the-emotional-intelligence-education-programme-on-quality-of-life-in-haemodialysis-patients
#12
Masoome Shahnavazi, Zohreh Parsa-Yekta, Mir-Saeed Yekaninejad, Sara Amaniyan, Pauline Griffiths, Mojtaba Vaismoradi
AIM: This study investigated the effect of the emotional intelligence education programme on quality of life of haemodialysis patients. BACKGROUND: Nurses need knowledge development regarding the impact of educational strategies on patients' quality of life suffering from chronic diseases. METHODS: A pragmatic quasi-randomized controlled trial was conducted with 47 haemodialysis patients attending a university hospital in an urban area of Iran...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29420730/clinical-differences-between-men-and-women-undergoing-surgery-for-acute-type-a-aortic-dissection
#13
Tomoaki Suzuki, Tohru Asai, Takeshi Kinoshita
OBJECTIVES: The differences in clinical features, surgical outcome and long-term prognosis between men and women who undergo surgery for Type A aortic dissection are not well known. METHODS: From January 2004 to December 2016, 303 patients, consisting of 147 women and 156 men, underwent surgery for acute Type A aortic dissection at our institution. We compared clinical outcomes between the 2 cohorts. RESULTS: Women were older than men (72...
February 6, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29415360/metformin-induced-encephalopathy-the-role-of-thiamine
#14
Caoimhe McGarvey, Catherine Franconi, David Prentice, Michael Bynevelt
A case of metformin encephalopathy is presented in a patient on haemodialysis for end-stage diabetic renal failure. The patient presented with frequent falls and clinical signs of Parkinsonism, on a background of recent anorexia and significant weight loss. Magnetic resonance imaging showed bilateral, symmetrical abnormalities centred on the lentiform nuclei. Metformin was withheld and signs and symptoms quickly resolved. We hypothesise that metformin may cause thiamine deficiency in patients with end-stage renal failure resulting in a specific metabolic encephalopathy...
February 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29402827/expanded-haemodialysis-therapy-of-chronic-haemodialysis-patients-prevents-calcification-and-apoptosis-of-vascular-smooth-muscle-cells-in-vitro
#15
Kevin Willy, Matthias Girndt, Jakob Voelkl, Roman Fiedler, Peter Martus, Markus Storr, Ralf Schindler, Daniel Zickler
BACKGROUND: Vascular calcification is a common phenomenon in patients with chronic kidney disease and strongly associated with increased cardiovascular mortality. Vascular calcification is an active process mediated in part by inflammatory processes in vascular smooth muscle cells (VSMC). These could be modified by the insufficient removal of proinflammatory cytokines through conventional high-flux (HF) membranes. Recent trials demonstrated a reduction of inflammation in VSMC by use of dialysis membranes with a higher and steeper cut-off...
December 22, 2017: Blood Purification
https://www.readbyqxmd.com/read/29401294/the-first-365-days-on-haemodialysis-variation-in-the-haemodialysis-access-journey-and-its-associated-burden
#16
Eleanor Murray, Mahmoud Eid, Jamie P Traynor, Karen S Stevenson, Ram Kasthuri, David B Kingsmore, Peter C Thomson
Background: The modality by which haemodialysis (HD) is delivered [arteriovenous fistula (AVF), arteriovenous graft (AVG) or central venous catheter (CVC)] varies widely and is influenced by clinical evidence, patient factors and the prevailing service configuration. The aim of this study was to determine the outcome and impact of access strategy on patient outcome by mapping out the HD journey in a cohort of incident patients. Methods: A 2-year cohort of consecutive incident HD patients from the point of referral for first dialysis access to completion of the first 365 days of HD was prospectively reviewed...
February 1, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29392552/a-decision-analytic-model-to-assess-the-cost-effectiveness-of-etelcalcetide-vs-cinacalcet
#17
Björn Stollenwerk, Sergio Iannazzo, Ron Akehurst, Michael Adena, Andrew Briggs, Bastian Dehmel, Patrick Parfrey, Vasily Belozeroff
INTRODUCTION: Etelcalcetide is a novel intravenous calcimimetic for the treatment of secondary hyperparathyroidism (SHPT) in haemodialysis patients. The clinical efficacy and safety of etelcalcetide (in addition to phosphate binders and vitamin D and/or analogues [PB/VD]) was evaluated in three phase III studies, including two placebo-controlled trials and a head-to-head study versus the oral calcimimetic cinacalcet. OBJECTIVE: The objective of this study was to develop a decision-analytic model for economic evaluation of etelcalcetide compared with cinacalcet...
February 2, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29391358/wave-of-renal-impairment
#18
Helena Pinto, Ana Catarina Teixeira, Nuno Oliveira, Rui Alves
We present a case of a 51-year-old man who went to the emergency department after an almost-drowning episode, presenting with muscular weakness, myalgia and dark urine. Laboratory data showed a severe rhabdomyolysis (creatine kinase 497 510 U/L). Despite aggressive fluid therapy, an oliguric acute kidney injury was established with temporary need of haemodialysis. The patient had a longtime history of exercise intolerance and family history of a metabolic myopathy, namely a sister with McArdle's disease...
February 1, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29391354/metformin-associated-lactic-acidosis-mimicking-ischaemic-bowel
#19
Sajjad Ali, Heloise Labuschagne, Nickolay Azarov, Zakaria Hindi, Lavi Oud
Metformin-associated lactic acidosis (MALA) is a rare complication among patients who are diabetic, commonly presenting with non-specific findings, and developing mostly among those with other risk factors for lactic acidosis. We report the development of MALA in a 67-year-old man with diabetes who presented with progressive abdominal pain and bloody diarrhoea. On presentation the patient was in shock, with signs suggestive of peritonitis, and with severe lactic acidosis, renal failure and non-specific findings on abdominal CT...
February 1, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29390243/-bardet-biedl-syndrome-and-kidney-failure-a-case-report
#20
Fabio Tattoli, Daniela Falconi, Chiara Bottaro, Maurizio Gherzi, Federico Marazzi, Marita Marengo, Ilaria Serra, Michela Tamagnone, Marco Formica
Bardet-Biedl Syndrome (BBS) is a rare multi-systemic disease with autosomal recessive transmission. BBS was at first considered to be homogeneous as for its genetics, but subsequent studies have shown an extensive gene variability. Currently, 21 genes (BBS1-21) present on different chromosomes have been mapped: these genes are responsible for BBS phenotypes and they show a great heterogeneity of mutations.The most common genes are BBS1 (locus 11q13) and BBS10.We show here the case of a 50 year old patient with BBS...
February 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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