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Primary mediastinic lymphoma

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https://www.readbyqxmd.com/read/27888880/optimizing-outcomes-in-primary-mediastinal-b-cell-lymphoma
#1
REVIEW
Pier Luigi Zinzani, Alessandro Broccoli
Primary mediastinal B-cell lymphoma is characterized by a high chance of cure, and cured patients have a long disease-free life-expectancy; however, prognosis is severe in the case of relapsed or refractory disease. The initial use of the most effective chemoimmunotherapy regimen is therefore crucial. Understanding who will benefit from postinduction radiotherapy is also of paramount importance; positron emission tomography may be a reliable guide for physicians in determining which patients will require consolidation...
December 2016: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27884092/a-retrospective-analysis-of-outcomes-for-primary-mediastinal-large-b-cell-lymphoma-treated-with-rchop-followed-by-radiotherapy-or-front-line-autologous-stem-cell-transplantation
#2
Xiaojian Liu, Ting Deng, Xianzhi Guo, Ye Guo, Leiping Wang, Jian Zhang, Zuguang Xia, Quanling Zhang, Kai Xue, Junning Cao, Jumei Shi, Xiaonan Hong
OBJECTIVES: Our aim was to retrospectively investigate the data from our institute the response rate and outcome in patients with primary mediastinal B-cell lymphoma (PMBL) who received the rituximab in combination with CHOP (RCHOP) followed by autologous stem cell transplantation (ASCT) or RCHOP followed by involved field radiation therapy (IFRT). METHODS: Sixty five patients with PMBL received RCHOP as first-line chemotherapy between January 2005 and December 2010...
November 25, 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/27879516/performance-of-a-commercially-available-mal-antibody-in-the-diagnosis-of-primary-mediastinal-large-b-cell-lymphoma
#3
Michael Gentry, Juraj Bodo, Lisa Durkin, Eric D Hsi
Myelin and lymphocyte (MAL) protein has been previously reported as a highly specific marker for distinguishing primary mediastinal large B-cell lymphoma (PMBL) from diffuse large B-cell lymphoma, not otherwise specified (DLBCL, NOS). However, there has not been a commercially available MAL antibody for immunohistochemistry. We identified a commercially available MAL monoclonal antibody and evaluated it by immunohistochemistry on 43 cases of PMBL and 63 cases of DLBCL, NOS. We also compared this with a CD200 antibody that was previously reported useful in distinguishing PMBL and DLBCL, NOS...
November 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27866679/-hodgkin-and-non-hodgkin-lymphoma-of-adolescents-and-young-adults
#4
REVIEW
Sylvain Garciaz, Diane Coso, Pauline Brice, Réda Bouabdallah
Lymphoma is one of the most frequent cancers in adolescent and young adults. Hodgkin Lymphoma is curable in more than 90% of cases. Recent pediatric and adults protocols aimed to decrease long term toxicities (mostly gonadic and cardiovascular) and secondary malignancies, reducing the use of alkylating agents and limiting radiation fields. Risk-adapted strategies, using positron emission tomography staging, are about to become a standard, both in adult and pediatric protocols. These approaches allow obtaining excellent results in adolescents with Hodgkin lymphoma...
November 17, 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27861596/pd-l1-status-in-refractory-lymphomas
#5
Semir Vranic, Nilanjan Ghosh, Jeffery Kimbrough, Nurija Bilalovic, Ryan Bender, David Arguello, Yvonne Veloso, Aida Dizdarevic, Zoran Gatalica
Targeted immunotherapy based on PD-1/PD-L1 suppression has revolutionized the treatment of various solid tumors. A remarkable improvement has also been observed in the treatment of patients with refractory/relapsing classical Hodgkin lymphoma (cHL). We investigated PD-L1 status in a variety of treatment resistant lymphomas. Tumor samples from 78 patients with therapy resistant lymphomas were immunohistochemically (IHC) investigated for the expression of PD-L1 using two antibody clones (SP142 and SP263, Ventana)...
2016: PloS One
https://www.readbyqxmd.com/read/27858330/primary-mediastinal-large-b-cell-lymphoma-in-japanese-children-and-adolescents
#6
Tomoo Osumi, Fumiko Tanaka, Tetsuya Mori, Reiji Fukano, Masahito Tsurusawa, Koichi Oshima, Atsuko Nakazawa, Ryoji Kobayashi
This is the first case series to describe primary mediastinal large B-cell lymphoma (PMLBL) patients in children and adolescents in Asia. We retrospectively identified 17 PMLBL patients diagnosed between 1991 and 2014; in seven of these cases, the diagnosis was confirmed by central review, representing 1.0% of all NHL and 2.2% of all B-NHL cases registered. All patients were teenagers, including seven adolescents, with a median age of 14 years (range 12-18 years). Ten patients were male, and seven were female...
November 17, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27810107/tracheobronchial-obstruction-caused-by-primary-mediastinal-lymphoma
#7
María Luisa Valle Feijoo, Violeta Turcu, Fernando Iglesias Río, Ceferino Gutiérrez Mendiguchia
No abstract text is available yet for this article.
October 31, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27806315/primary-mediastinal-large-b-cell-lymphoma-transcriptional-regulation-by-mir-92a-through-foxp1-targeting
#8
Martha Romero, Guillaume Gapihan, Luis Jaime Castro-Vega, Andrés Acevedo, Li Wang, Zhao Wei Li, Morad El Bouchtaoui, Mélanie Di Benedetto, Philippe Ratajczak, Jean-Paul Feugeas, Catherine Thieblemont, Carlos Saavedra, Anne Janin
BACKGROUND: Primary mediastinal large B-cell lymphoma (PMBL) shares pathological features with diffuse large B-cell lymphoma (DLBCL), and molecular features with classical Hodgkin lymphoma (cHL). The miR-17~92 oncogenic cluster, located at chromosome 13q31, is a region that is amplified in DLBCL. METHODS: Here we compared the expression of each member of the miR-17~92 oncogenic cluster in samples from 40 PMBL patients versus 20 DLBCL and 20 cHL patients, and studied the target genes linked to deregulated miRNA in PMBL...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27803409/primary-mediastinal-large-b-cell-lymphoma-exhibiting-endobronchial-involvement
#9
Midori Shimada, Minoru Fukuda, Kensuke Horio, Takayuki Suyama, Takeshi Kitazaki, Kohji Hashiguchi, Masaaki Fukuda, Kazuto Shigematsu, Yoichi Nakamura, Takuya Honda, Kazuto Ashizawa, Hiroshi Mukae
Primary mediastinal large B-cell lymphoma (PMLBCL) is one of the subtypes of diffuse large B-cell lymphoma. We experienced a rare case of PMLBCL that exhibited endobronchial involvement. A 33-year-old Japanese female with the chief complaints of epigastralgia, back pain, and nausea visited a primary care hospital. Computed tomography of the chest and abdomen demonstrated a bulky mass in the left anterior mediastinum, multiple pulmonary nodules, axillary lymph node swelling, and a pancreatic tumor. Fiberoptic bronchoscopy showed a white-tinged irregularly shaped endobronchial tumor accompanied by capillary vessel dilation in the left upper lobar bronchus...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27795778/-primary-mediastinal-large-b-cell-lymphoma-in-women-about-five-cases
#10
Safaa Ouassou, Laila Herrak, Leila Achachi, Fatima Nachite, Kaoutar Znati, Mustapha El Ftouh
Primary mediastinal large B-cell lymphoma (PMBL) is a lymphoma occurring in the anterior mediastinum starting from the cells B of the thymique medullary zone. This is a rare entity characterized by epidemiological, clinical and evolutionary peculiarities as well as by pathological and immunohistochemical peculiarities. We report a case series of 5 patients with diagnosed PMBL hospitalized in Pulmonology Department of Ibn Sina Hospital between January 2012 and May 2016. The average age was 34 years, the median of consultation time was 2 months...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27758822/mediastinal-grey-zone-lymphoma-clinico-pathological-characteristics-and-outcomes-of-99-patients-from-the-lysa
#11
Clémentine Sarkozy, Thierry Molina, Hervé Ghesquières, Anne-Sophie Michallet, Jehan Dupuis, Diane Damotte, Franck Morsschauser, Marie Parrens, Laurent Martin, Peggy Dartigues, Aspasia Stamatoullas, Pierre Hirsch, Betina Fabiani, Krimo Bouabdallah, Maria Gomes da Silva, Marie Maerevoet, Camille Laurent, Bertrand Coiffier, Gilles Salles, Alexandra Traverse-Glehen
Mediastinal grey zone lymphoma, B cell lymphomas with intermediate features between classical Hodgkin lymphoma and primary mediastinal B cell lymphoma, are not well described in the literature. We report the clinical characteristics and outcomes of a large retrospective series of 99 cases centrally reviewed by a panel of hematopathologists, with a consensus established for the diagnosis. Cases were defined as classical Hodgkin lymphoma-like morphology (64.6%) with primary mediastinal B cell lymphoma immunophenotype, primary mediastinal B cell lymphoma-like morphology (30...
October 6, 2016: Haematologica
https://www.readbyqxmd.com/read/27729935/a-case-of-s-100-negative-melanoma-a-diagnostic-pitfall-in-the-workup-of-a-poorly-differentiated-metastatic-tumor-of-unknown-origin
#12
Anna Biernacka, Konstantinos D Linos, Peter A DeLong, Arief A Suriawinata, Vijayalakshmi Padmanabhan, Xiaoying Liu
When confronted with a metastatic poorly differentiated tumor of unknown origin, the initial workup includes the standard panel of immunostains to rule out carcinoma, sarcoma, lymphoma, and the greatest mimicker in pathology - malignant melanoma. Although not specific, the S-100 protein is expressed in over 95% of malignant melanomas. Herein, we present a case of multiorgan metastatic malignancy with a dominant hilar and mediastinal mass in a current smoker; clinically, highly suggestive of widespread primary lung cancer...
2016: CytoJournal
https://www.readbyqxmd.com/read/27725597/clinical-manifestation-and-treatment-of-extranodal-diffuse-large-b-cell-lymphoma
#13
Naoto Tomita
Diffuse large B-cell lymphoma (DLBCL) accounts for 30-40% of all lymphoma subtypes. More than half of DLBCLs are estimated to arise from extranodal sites, and are called extranodal DLBCLs. Generally, the outcomes of extranodal DLBCL are not different from those of nodal DLBCL. To our knowledge, this report is the first to discuss the concept and the cell of origin of extranodal DLBCL, with the significance of the presence/absence of each involvement site in determining the outcome. Second, the evidence of clinical manifestation and outcomes of several extranodal DLBCLs requiring treatments other than R-CHOP, which is the current standard therapy for this malignancy, are discussed...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27688726/primary-mediastinal-b-cell-lymphoma-metabolic-and-anatomical-features-in-18fdg-pet-ct-and-response-to-therapy
#14
Anna Kocurek, Bogdan Małkowski, Agnieszka Giza, Wojciech Jurczak
AIM OF THE STUDY: Determining the role of PET/CT imaging in the evaluation of treatment efficacy in primary mediastinal B-cell lymphoma (PMBCL). MATERIAL AND METHODS: Retrospective analysis of seven PMBCL patients, treated at the University Hospital in Krakow, with interim PET/CT after the third course of chemo-immunotherapy.The analysis was based on the calculation of exact tumour volume and metabolic activity, compared with initial values (directly after diagnosis)...
2016: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/27679780/cd4-positive-diffuse-large-b-cell-lymphoma-a-variant-with-aggressive-clinical-potential
#15
REVIEW
Mohammad O Hussaini, Friederike H Kreisel, Anjum Hassan, TuDung T Nguyen, John L Frater
CD4 expression is rare in diffuse large B-cell lymphoma (DLBCL), with 4 previously reported cases. Its significance is uncertain. We report five patients with CD4(+) DLBCL and one CD4(+) primary mediastinal large B-cell lymphoma. Cases were identified by searching the electronic database of the department; each was reviewed. Average age was 56 years. Neoplastic cells expressed CD20 (5/6 tested cases). BCL2/BCL6 expression were seen in 3/3 tested cases, suggesting a germinal center origin. Additionally, expression of T-cell antigens CD2 and CD5 was noted in 2/2 and CD7 in 1/1 tested case...
September 26, 2016: World Journal of Methodology
https://www.readbyqxmd.com/read/27675775/utilization-of-positron-emission-tomography-computed-tomography-parameters-to-identify-patients-at-risk-for-progression-after-treatment-with-dose-adjusted-r-epoch-for-primary-mediastinal-b-cell-lymphoma-pmbcl
#16
C C Pinnix, Z Abou Yehia, W Qiao, S A Milgrom, G L Smith, M Akhtari, J Reddy, J R Gunther, E M Osborne, O R Mawlawi, L J Medeiros, N Garg, H H Chuang, S Neelapu, J R Westin, B Dabaja
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27670424/frequent-nfkbie-deletions-are-associated-with-poor-outcome-in-primary-mediastinal-b-cell-lymphoma
#17
Larry Mansouri, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, Viktor Ljungström, Markus Schneider, Kenichi Yoshida, Aron Skaftason, Tatjana Pandzic, Blanca Gonzalez, Anna Tasidou, Nils Waldhueter, Alfredo Rivas-Delgado, Maria Angelopoulou, Marita Ziepert, Christopher Maximilian Arends, Lucile Couronné, Dido Lenze, Claudia D Baldus, Christian Bastard, Jessica Okosun, Jude Fitzgibbon, Bernd Dörken, Hans G Drexler, Damien Roos-Weil, Clemens A Schmitt, Helga D Munch-Petersen, Thorsten Zenz, Martin-Leo Hansmann, Jonathan C Strefford, Gunilla Enblad, Olivier A Bernard, Elisabeth Ralfkiaer, Martin Erlanson, Penelope Korkolopoulou, Magnus Hultdin, Theodora Papadaki, Kirsten Grønbæk, Armando Lopez-Guillermo, Seishi Ogawa, Ralf Küppers, Kostas Stamatopoulos, Niki Stavroyianni, George Kanellis, Andreas Rosenwald, Elias Campo, Rose-Marie Amini, German Ott, Theodoros P Vassilakopoulos, Michael Hummel, Richard Rosenquist, Frederik Damm
We recently reported a truncating deletion in the NFKBIE gene, which encodes IκBε, a negative feedback regulator of NF-κB, in clinically aggressive chronic lymphocytic leukemia (CLL). Because preliminary data indicate enrichment of NFKBIE aberrations in other lymphoid malignancies, we screened a large patient cohort (n = 1460) diagnosed with different lymphoid neoplasms. While NFKBIE deletions were infrequent in follicular lymphoma, splenic marginal zone lymphoma, and T-cell acute lymphoblastic leukemia (<2%), slightly higher frequencies were seen in diffuse large B-cell lymphoma, mantle cell lymphoma, and primary central nervous system lymphoma (3% to 4%)...
December 8, 2016: Blood
https://www.readbyqxmd.com/read/27630351/lymphoma-of-the-cervix-case-report-and-review-of-the-literature
#18
Ziad Hilal, Franziska Hartmann, Askin Dogan, Cem Cetin, Harald Krentel, Sven Schiermeier, Beate Schultheis, Clemens B Tempfer
BACKGROUND: Lymphoma of the uterine cervix (LUCX) is rare and may occur as a primary or secondary manifestation of this disease. Clinical and cytological presentations of LUCX vary and establishing diagnosis is often difficult. Surgery followed by radiation or chemotherapy is the mainstay of treatment. CASE REPORT: We present the case of a 73-year-old woman with recurrent pathological PAP smears of the cervix and a history of chronic lymphatic leukemia 15 years ago...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27629966/primary-marginal-zone-lymphoma-in-the-posterior-mediastinum-with-pleural-involvement
#19
Shigeki Shimizu, Yasushi Inoue, Tomoki Utsumi, Tomohisa Okuma, Tomoya Kawaguchi, Takahiko Kasai, Satoru Munakata, Masaru Shibano, Shinji Atagi
We herein report a case of primary marginal zone lymphoma (MZL) of the posterior mediastinum in an 84-year-old woman. Computed tomography of the chest showed a posterior mediastinal mass in the right thoracic paravertebral region with right pleural effusion. Pathological findings of a surgical biopsy from the posterior mediastinum, along with immunohistochemical and flow cytometric results, indicated MZL. The patient was treated with chemotherapy and radiation therapy for the mediastinal lesion and achieved complete remission...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27623181/mediastinal-gray-zone-lymphoma-with-features-intermediate-between-classical-hodgkin-lymphoma-and-primary-mediastinal-b-cell-lymphoma
#20
Haa-Na Song, Seok Jin Kim, Young Hyeh Ko, Won Seog Kim
BACKGROUND: Mediastinal gray zone lymphoma (MGZL) shares clinical characteristics with primary mediastinal B-cell lymphoma (PMBCL) and nodular sclerosing Hodgkin lymphoma (NSHL). However, MGZL is extremely rare, and an appropriate treatment for it has not yet been established. METHODS: We retrospectively analyzed 8 patients who were treated with systemic chemotherapy for MGZL between 2007 and 2014. RESULTS: The patients with MGZL were predominantly young and male (median age 26 years), and 62...
2016: Acta Haematologica
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