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https://www.readbyqxmd.com/read/29643395/low-intensity-repetitive-transcranial-magnetic-stimulation-requires-concurrent-visual-system-activity-to-modulate-visual-evoked-potentials-in-adult-mice
#1
Kalina Makowiecki, Andrew Garrett, Alan R Harvey, Jennifer Rodger
Repetitive transcranial stimulation (rTMS) is an increasingly popular method to non-invasively modulate cortical excitability in research and clinical settings. During rTMS, low-intensity magnetic fields reach areas perifocal to the target brain region, however, effects of these low-intensity (LI-) fields and how they interact with ongoing neural activity remains poorly defined. We evaluated whether coordinated neural activity during electromagnetic stimulation alters LI-rTMS effects on cortical excitability by comparing visually evoked potentials (VEP) and densities of parvalbumin-expressing (PV+) GABAergic interneurons in adult mouse visual cortex after LI-rTMS under different conditions: LI-rTMS applied during visually evoked (strong, coordinated) activity or in darkness (weak, spontaneous activity)...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29625467/detection-of-amblyopia-using-sweep-vep-vernier-and-grating-acuity
#2
Chuan Hou, William V Good, Anthony M Norcia
Purpose: Vernier and grating acuity can be measured with swept-parameter visual evoked potentials (sVEP). However, whether sVEP Vernier and grating acuities are comparable in predicting letter acuity has not been systematically evaluated. This study evaluated the validity and reliability of sVEP Vernier and grating acuity for the detection of amblyopia in adults. Methods: Three types of acuity were measured in 36 adults with amblyopia and 36 age-matched normal-vision controls...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29623523/visual-evoked-potentials-can-be-reliably-recorded-using-noninvasive-epidermal-electrodes-in-the-anesthetized-rat
#3
Roberto Santangelo, Valerio Castoldi, Raffaele D'Isa, Silvia Marenna, Su-Chun Huang, Marco Cursi, Giancarlo Comi, Letizia Leocani
PURPOSE: Visual evoked potentials (VEPs) are a powerful tool to evaluate nervous conduction along the visual pathways, both in humans and in animal models. Traditionally, epidural screw electrodes are used to record VEPs in preclinical research. Here we tested the feasibility in the preclinical setting of the same noninvasive technique used for clinical VEP acquisition, by using epidermal cup electrodes with no surgical procedures. METHODS: Monocular flash VEPs were recorded bilaterally under sevoflurane anesthesia once a week for 6 weeks in 14 dark Agouti rats, 7 with implanted epidural screws and 7 with epidermal 6 mm Ø Ag/AgCl cups...
April 5, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29621385/the-effects-of-red-surrounds-on-visual-magnocellular-and-parvocellular-cortical-processing-and-perception
#4
Laila Hugrass, Thomas Verhellen, Eleanore Morrall-Earney, Caitlin Mallon, David Philip Crewther
More than 50 years ago, Hubel and Wiesel identified a subpopulation of geniculate magnocellular (M) neurons that are suppressed by diffuse red light. Since then, many human psychophysical studies have used red and green backgrounds to study the effects of M suppression on visual task performance, as a means to better understand neurodevelopmental disorders such as dyslexia and schizophrenia. Few of these studies have explicitly assessed the relative effects of red backgrounds on the M and P (parvocellular) pathways...
April 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29600911/intraoperative-monitoring-with-visual-evoked-potentials-for-brain-surgeries
#5
Eveline M Gutzwiller, Ivan Cabrilo, Ivan Radovanovic, Karl Schaller, Colette Boëx
OBJECTIVE The goal of this study was to determine the performance of intraoperative visual evoked potentials (VEPs) in detecting visual field changes. METHODS Assessments of VEPs were performed with simultaneous retinal responses by using white light-emitting diodes protected from scialytic microscope lights. The alarm criterion was a reproducible decrease in amplitude of the VEP P100 wave of 20% or more. Visual fields were assessed preoperatively and 1 month postsurgery (Goldmann perimetry). RESULTS The VEPs were analyzed for 29 patients undergoing resection of a brain lesion...
March 30, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29568651/a-study-of-the-correlation-between-vep-and-clinical-severity-in-children-with-autism-spectrum-disorder
#6
Winai Sayorwan, Nutthida Phianchana, Kannika Permpoonputtana, Vorasith Siripornpanich
Visual evoked potential (VEP) is a technique used to assess the brain's electrical response to visual stimuli. The aims of this study were to examine neural transmission within the visual pathway through VEP testing in preschool children with autism spectrum disorder (ASD) and compare it to age-matched controls, as well as search for a correlation between the VEP parameters and the symptoms of ASD. Participants were composed of ASD children (9 males) and typically developing children (8 males and 4 females), aged between 3 and 5 years...
2018: Autism Research and Treatment
https://www.readbyqxmd.com/read/29565474/implantation-of-adipose-derived-stem-cells-cures-the-optic-nerve-injury-on-rats-through-inhibiting-the-expression-of-inflammation-factors-in-the-tlr4-signaling-pathway
#7
L-J Wang, L-P Liu, X L Gu, M Wang, L-M Liu
OBJECTIVE: The use of adipose-derived stem cells (ADSCs) to cure the optic nerve injury was never shown previously. Here, we implanted purified ADSCs into optic nerve injury of rats. MATERIALS AND METHODS: Male Sprague Dawley (SD) rats were used in this study. The vision degeneration was detected by Flash-visual evoked potential (F-VEP) assay. The expression of Macrophage-1 (Mac-1), myeloid differentiation factor 88 (MyD88), and nuclear transcription factor-κB (NF-κB) were studied by Western blot...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29541531/shades-of-grey-assessing-the-contribution-of-the-magno-and-parvocellular-systems-to-neural-processing-of-the-retinal-input-in-the-human-visual-system-from-the-influence-of-neural-population-size-and-its-discharge-activity-on-the-vep
#8
Valentine L Marcar, Silvana Baselgia, Barbara Lüthi-Eisenegger, Lutz Jäncke
Introduction: Retinal input processing in the human visual system involves a phasic and tonic neural response. We investigated the role of the magno- and parvocellular systems by comparing the influence of the active neural population size and its discharge activity on the amplitude and latency of four VEP components. Method: We recorded the scalp electric potential of 20 human volunteers viewing a series of dartboard images presented as a pattern reversing and pattern on-/offset stimulus...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29541433/effects-of-levothyroxine-on-visual-evoked-potential-impairment-following-local-injections-of-lysolecithin-into-the-rat-optic-chiasm
#9
Cobra Payghani, Fatemeh Khani, Aryan Rafieezadeh, Parham Reisi, Hojjatallah Alaei, Bahman Rashidi
Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system which has no any known definitive treatment. Studies have shown that thyroid hormones (THs) in addition to their roles in the development of the nervous system and the production of myelin have important roles in the adult's brain function. Since the only way to treat MS is the restoration of myelin, the aim of this study was to evaluate the effects of levothyroxine on visual evoked potential (VEP) impairment following local injections of lysolecithin into the rat optic chiasm...
2018: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29539190/mseqdr-mvtool-a-mitochondrial-dna-web-and-api-resource-for-comprehensive-variant-annotation-universal-nomenclature-collation-and-reference-genome-conversion
#10
Lishuang Shen, Marcella Attimonelli, Renkui Bai, Marie T Lott, Douglas C Wallace, Marni J Falk, Xiaowu Gai
Accurate mitochondrial DNA (mtDNA) variant annotation is essential for the clinical diagnosis of diverse human diseases. Substantial challenges to this process include the inconsistency in mtDNA nomenclatures, the existence of multiple reference genomes, and a lack of reference population frequency data. Clinicians need a simple bioinformatics tool that is user-friendly, and bioinformaticians need a powerful informatics resource for programmatic usage. Here, we report the development and functionality of the MSeqDR mtDNA Variant Tool set (mvTool), a one-stop mtDNA variant annotation and analysis web service...
March 14, 2018: Human Mutation
https://www.readbyqxmd.com/read/29536594/detailed-spatiotemporal-brain-mapping-of-chromatic-vision-combining-high-resolution-vep-with-fmri-and-retinotopy
#11
Sabrina Pitzalis, Francesca Strappini, Alessandro Bultrini, Francesco Di Russo
Neuroimaging studies have identified so far, several color-sensitive visual areas in the human brain, and the temporal dynamics of these activities have been separately investigated using the visual-evoked potentials (VEPs). In the present study, we combined electrophysiological and neuroimaging methods to determine a detailed spatiotemporal profile of chromatic VEP and to localize its neural generators. The accuracy of the present co-registration study was obtained by combining standard fMRI data with retinotopic and motion mapping data at the individual level...
March 13, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29536386/long-term-therapy-with-miglustat-and-cognitive-decline-in-the-adult-form-of-niemann-pick-disease-type-c-a-case-report
#12
Stefano Tozza, Raffaele Dubbioso, Rosa Iodice, Antonietta Topa, Marcello Esposito, Lucia Ruggiero, Emanuele Spina, Anna De Rosa, Francesco Saccà, Lucio Santoro, Fiore Manganelli
Niemann-Pick disease type C (NPC) is a recessive lysosomal lipid storage disorder characterized by central nervous system involvement. Miglustat treatment might improve or stabilize neurological manifestations but there is still limited data on the long-term efficacy. The aim of our study was to report a four-year clinical, neuropsychological and electrophysiological follow-up of two sisters under treatment with miglustat. We report data at basal (T0) and after 4 years (T4) of treatment with miglustat from two sisters (P1 and P2) affected by NPC disease...
March 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29532216/early-isolated-optic-neuropathy-caused-by-cyclosporine
#13
Karin Mimouni, Moshe Lusky, Michal Kramer, Michael Gdalevich, Dov Weinberger, Michael Mimouni
PURPOSE: To examine, for the first time, whether cyclosporine intake has an early isolated effect on the optic nerve. MATERIALS AND METHODS: This observational case series consisted of 192 eyes of 98 patients treated with cyclosporine. Patient age and duration and dosage of cyclosporine were recorded, and visual acuity, optic nerve function, visual fields, and visual evoked potential (VEP) were tested. Fundus examination was also performed. Patients with glaucoma, vascular retinopathies, and deep amblyopia were excluded...
March 12, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29523043/light-axis-adjustment-with-a-sterilised-photostimulation-device-for-visually-evoked-potential-monitoring
#14
Masanori Yoshino, Takayuki Hara
Intraoperative monitoring of visually evoked potentials (VEPs) is sometimes unachievable because of light axis misalignments caused by frontal scalp-flap reflection and intraoperative manipulation. Here, we present a new method of intraoperative VEP monitoring that involves a sterilised photostimulation device that can be adjusted in position following disturbances from frontal scalp-flap reflection or intraoperative manipulation.
March 9, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29515351/interhemispheric-transfer-time-asymmetry-of-visual-information-depends-on-eye-dominance-an-electrophysiological-study
#15
Romain Chaumillon, Jean Blouin, Alain Guillaume
The interhemispheric transfer of information is a fundamental process in the human brain. When a visual stimulus appears eccentrically in one visual-hemifield, it will first activate the contralateral hemisphere but also the ipsilateral one with a slight delay due to the interhemispheric transfer. This interhemispheric transfer of visual information is believed to be faster from the right to the left hemisphere in right-handers. Such an asymmetry is considered as a relevant fact in the context of the lateralization of the human brain...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29504295/optical-coherence-tomography-versus-visual-evoked-potentials-for-detecting-visual-pathway-abnormalities-in-patients-with-neuromyelitis-optica-spectrum-disorder
#16
Nam Hee Kim, Ho Jin Kim, Cheol Yong Park, Kyoung Sook Jeong, Joong Yang Cho
BACKGROUND AND PURPOSE: Optical coherence tomography (OCT) and visual evoked potentials (VEPs) can be used to detect optic neuritis (ON). However, the comparative sensitivities of OCT and VEPs for detecting ON in neuromyelitis optica spectrum disorder (NMOSD) are unclear, and so we assessed these sensitivities. METHODS: This cross-sectional study included 73 patients with aquaporin-4 antibody-seropositive NMOSD, and 101 eyes with ON. The clinical characteristics, visual acuity (VA), Expanded Disability Status Scale (EDSS) scores, OCT peripapillary retinal nerve fiber layer (RNFL) thickness, and VEPs of the patients were evaluated...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29501770/querectin-improves-myelin-repair-of-optic-chiasm-in-lyolecithin-induced-focal-demyelination-model
#17
Reza Naeimi, Saeideh Baradaran, Manouchehr Ashrafpour, Ali Akbar Moghadamnia, Maryam Ghasemi-Kasman
Although the beneficial effects of quercetin on oligodendrocyte precursor cell (OPCs) population has been evaluated in-vitro, there are few studies about the effects of quercetin on myelin repair in the context of demyelination. The aim of this study was to investigate the effects of querectin on functional recovery and myelin repair of optic chiasm in lysolecithin (LPC)-induced demyelination model. Demyelination was induced by local injection of LPC 1% (2 μl) into rat optic chiasm. Querectin at doses 25 or 50 mg/kg was administrated daily by oral gavage for 7 or 14 days post LPC...
March 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29489683/assessment-of-visual-evoked-potentials-in-patients-eligible-for-penetrating-keratoplasty
#18
Wojciech Mańkowski, Adam Wylęgała, Edward Wylęgała
Corneal opacities can obstruct ophthalmology examination in patients before penetrating keratoplasty (PK).To assess the usefulness of visual evoked potentials (VEPs) in estimating postoperative visual acuity (VA) in patients eligible for (PK) with opaque cornea in 1 eye and good VA in the fellow eye.In this observational study, the mean age of 52 males and 48 females was 57.17 ± 15.99 (21-87 years old). A total of 100 patients eligible for PK underwent an ophthalmological examination including VA and a VEP examination...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29445236/retinotopic-effects-of-visual-attention-revealed-by-dichoptic-multifocal-pupillography
#19
Yanti Rosli, Corinne Frances Carle, Yiling Ho, Andrew Charles James, Maria Kolic, Emilie Marie Françoise Rohan, Ted Maddess
Multifocal pupillographic objective perimetry (mfPOP) has recently been shown to be able to measure cortical function. Here we assessed 44 regions of the central 60 degrees of the visual fields of each eye concurrently in 7 minutes/test. We examined how foveally- and peripherally-directed attention changed response sensitivity and delay across the 44 visual field locations/eye. Four experiments were completed comparing white, yellow and blue stimulus arrays. Experiments 1 to 4 tested 16, 23, 9 and 6 subjects, 49/54 being unique...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420653/estimating-the-mutational-load-for-cardiovascular-diseases-in-pakistani-population
#20
Muhammad Shakeel, Muhammad Irfan, Ishtiaq Ahmad Khan
The deleterious genetic variants contributing to certain diseases may differ in terms of number and allele frequency from population to population depending on their evolutionary background. Here, we prioritize the deleterious variants from Pakistani population in manually curated gene list already reported to be associated with common, Mendelian, and congenital cardiovascular diseases (CVDs) using the genome/exome sequencing data of Pakistani individuals publically available in 1000 Genomes Project (PJL), and Exome Aggregation Consortium (ExAC) South Asia...
2018: PloS One
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