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https://www.readbyqxmd.com/read/29445236/retinotopic-effects-of-visual-attention-revealed-by-dichoptic-multifocal-pupillography
#1
Yanti Rosli, Corinne Frances Carle, Yiling Ho, Andrew Charles James, Maria Kolic, Emilie Marie Françoise Rohan, Ted Maddess
Multifocal pupillographic objective perimetry (mfPOP) has recently been shown to be able to measure cortical function. Here we assessed 44 regions of the central 60 degrees of the visual fields of each eye concurrently in 7 minutes/test. We examined how foveally- and peripherally-directed attention changed response sensitivity and delay across the 44 visual field locations/eye. Four experiments were completed comparing white, yellow and blue stimulus arrays. Experiments 1 to 4 tested 16, 23, 9 and 6 subjects, 49/54 being unique...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29420653/estimating-the-mutational-load-for-cardiovascular-diseases-in-pakistani-population
#2
Muhammad Shakeel, Muhammad Irfan, Ishtiaq Ahmad Khan
The deleterious genetic variants contributing to certain diseases may differ in terms of number and allele frequency from population to population depending on their evolutionary background. Here, we prioritize the deleterious variants from Pakistani population in manually curated gene list already reported to be associated with common, Mendelian, and congenital cardiovascular diseases (CVDs) using the genome/exome sequencing data of Pakistani individuals publically available in 1000 Genomes Project (PJL), and Exome Aggregation Consortium (ExAC) South Asia...
2018: PloS One
https://www.readbyqxmd.com/read/29415423/vitamin-e-phosphate-nucleoside-prodrugs-a-platform-for-intracellular-delivery-of-monophosphorylated-nucleosides
#3
Richard Daifuku, Michael Koratich, Murray Stackhouse
Vitamin E phosphate (VEP) nucleoside prodrugs are designed to bypass two mechanisms of tumor resistance to therapeutic nucleosides: nucleoside transport and kinase downregulation. Certain isoforms of vitamin E (VE) have shown activity against solid and hematologic tumors and result in chemosensitization. Because gemcitabine is one of the most common chemotherapeutics for the treatment of cancer, it was used to demonstrate the constructs utility. Four different VE isoforms were conjugated with gemcitabine at the 5' position...
February 6, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29408880/daily-visual-stimulation-in-the-critical-period-enhances-multiple-aspects-of-vision-through-bdnf-mediated-pathways-in-the-mouse-retina
#4
Amanda M Mui, Victoria Yang, Moe H Aung, Jieming Fu, Adewumi N Adekunle, Brian C Prall, Curran S Sidhu, Han Na Park, Jeffrey H Boatright, P Michael Iuvone, Machelle T Pardue
Visual experience during the critical period modulates visual development such that deprivation causes visual impairments while stimulation induces enhancements. This study aimed to determine whether visual stimulation in the form of daily optomotor response (OMR) testing during the mouse critical period (1) improves aspects of visual function, (2) involves retinal mechanisms and (3) is mediated by brain derived neurotrophic factor (BDNF) and dopamine (DA) signaling pathways. We tested spatial frequency thresholds in C57BL/6J mice daily from postnatal days 16 to 23 (P16 to P23) using OMR testing...
2018: PloS One
https://www.readbyqxmd.com/read/29398196/monitoring-of-optic-nerve-function-in-neurofibromatosis-2-children-with-optic-nerve-sheath-meningiomas-using-multifocal-visual-evoked-potentials
#5
V Jayanetti, A I Klistorner, S L Graham, M Dexter, M P Flaherty, K Jones, F A Billson, M Wilson, K North, J R Grigg, C L Fraser
Monitoring optic nerve sheath meningiomas (ONSM) in Neurofibromatosis type 2 (NF2) patients remains difficult. Other ocular manifestations of NF2 may obscure ophthalmic assessment of optic nerve function in these patients. Serial magnetic resonance imaging (MRI) used to assess the optic nerve is not without limitations, being expensive and often requiring general anaesthetic in children, with associated risks. This study was undertaken to describe the use of multifocal visual evoked potentials (multifocal VEP, mfVEP) in the regular monitoring of NF2 patients with ONSM...
February 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29397523/iscev-guide-to-visual-electrodiagnostic-procedures
#6
Anthony G Robson, Josefin Nilsson, Shiying Li, Subhadra Jalali, Anne B Fulton, Alma Patrizia Tormene, Graham E Holder, Scott E Brodie
Clinical electrophysiological testing of the visual system incorporates a range of noninvasive tests and provides an objective indication of function relating to different locations and cell types within the visual system. This document developed by the International Society for Clinical Electrophysiology of Vision provides an introduction to standard visual electrodiagnostic procedures in widespread use including the full-field electroretinogram (ERG), the pattern electroretinogram (pattern ERG or PERG), the multifocal electroretinogram (multifocal ERG or mfERG), the electrooculogram (EOG) and the cortical-derived visual evoked potential (VEP)...
February 3, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29367165/evaluation-of-afferent-pain-pathways-in-adrenomyeloneuropathic-patients
#7
Sara Yagüe, Misericordia Veciana, Carlos Casasnovas, Montserrat Ruiz, Jordi Pedro, Josep Valls-Solé, Aurora Pujol
OBJECTIVE: Patients with adrenomyeloneuropathy may have dysfunctions of visual, auditory, motor and somatosensory pathways. We thought on examining the nociceptive pathways by means of laser evoked potentials (LEPs), to obtain additional information on the pathophysiology of this condition. METHODS: In 13 adrenomyeloneuropathic patients we examined LEPs to leg, arm and face stimulation. Normative data were obtained from 10 healthy subjects examined in the same experimental conditions...
December 24, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29364268/visual-evoked-potential-recordings-in-mice-using-a-dry-non-invasive-multi-channel-scalp-eeg-sensor
#8
Chanmi Yeon, Donghyeon Kim, Kiseon Kim, Euiheon Chung
For scalp EEG research environments with laboratory mice, we designed a dry-type 16 channel EEG sensor which is non-invasive, deformable, and re-usable because of the plunger-spring-barrel structural facet and mechanical strengths resulting from metal materials. The whole process for acquiring the VEP responses in vivo from a mouse consists of four steps: (1) sensor assembly, (2) animal preparation, (3) VEP measurement, and (4) signal processing. This paper presents representative measurements of VEP responses from multiple mice with a submicro-voltage signal resolution and sub-hundred millisecond temporal resolution...
January 12, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29352131/early-impoverished-environment-delays-the-maturation-of-cerebral-cortex
#9
Roberta Narducci, Laura Baroncelli, Gabriele Sansevero, Tatjana Begenisic, Concetta Prontera, Alessandro Sale, Maria Cristina Cenni, Nicoletta Berardi, Lamberto Maffei
The influence of exposure to impoverished environments on brain development is unexplored since most studies investigated how environmental impoverishment affects adult brain. To shed light on the impact of early impoverishment on developmental trajectories of the nervous system, we developed a protocol of environmental impoverishment in which dams and pups lived from birth in a condition of reduced sensory-motor stimulation. Focusing on visual system, we measured two indexes of functional development, that is visual acuity, assessed by using Visual Evoked Potentials (VEPs), and VEP latency...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29332121/pattern-onset-ergs-and-veps-produced-by-patterns-arising-from-light-increment-and-decrement
#10
Dennis M Fritsch, Jane C Sowden, Dorothy A Thompson
Purpose: Our aim was to elaborate how on and off signals contribute to pattern ERGs and pattern visual evoked potentials (VEPs) by using pedestal patterns arising from incremental and decremental onset stimulation. Methods: Pattern onset/offset ERGs and VEPs were produced by black and white checks of 60' side length and 88% spatial contrast appearing in a 16° field for 200 ms from white (110 cd/m2), black (7 cd/m2), and gray (48 cd/m2) backgrounds and disappeared for 1000 ms...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29300714/electrophysiology-of-olfactory-and-optic-nerve-in-outpatient-and-intraoperative-settings
#11
Praveen Hariharan, Jeffery R Balzer, Katherine Anetakis, Donald J Crammond, Parthasarathy D Thirumala
Evoked potentials are time-locked electrophysiologic potentials recorded in response to standardized stimuli using scalp electrodes. These responses provide good temporal resolution and have been used in various clinical and intraoperative settings. Olfactory evoked potentials (OEPs) may be used as an adjunct tool in identifying patients of Parkinson disease and Alzheimer dementia. In clinical practice, visual evoked potentials (VEPs) are particularly useful in identifying subclinical cases of optic neuritis and in treatment surveillance...
January 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29286999/comprehensive-evaluation-of-visual-function-in-patients-with-orbital-fracture-by-visual-electrophysiology-and-visual-field-examination
#12
Shao-Rui Liu, Mao Li, Fang-Lin He, Zheng-Kang Li, Xian-Qun Fan
OBJECTIVE: At present, the effect of the visual electrophysiology and vision field examination in patients with orbital blowout fracture is rarely studied. So, the authors investigate the value of visual electrophysiology and vision field examination in the diagnosis of ocular contusion. METHODS: The position and range of fracture of 81 patients were determined by computed tomography (CT) scanning. Visual evoked potential (VEP), electroretinogram (ERG), and mfERG were vision field examination detected in 81 patients and the results were compared with those of contralateral healthy eyes...
January 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29241172/neurophysiological-monitoring-and-awake-craniotomy-for-resection-of-intracranial-gliomas
#13
Taiichi Saito, Manabu Tamura, Mikhail F Chernov, Soko Ikuta, Yoshihiro Muragaki, Takashi Maruyama
Aggressive resection of intracranial gliomas has a positive impact on patients' prognosis, but is associated with a risk of neurological complications. For preservation of brain functions and avoidance of major postoperative morbidity various methods of intraoperative neurophysiological monitoring have been introduced into clinical practice. At present, somatosensory evoked potentials (SSEP), motor evoked potentials (MEP), visual evoked potentials (VEP), brainstem auditory evoked potentials (BAEP), and electrocorticography (ECoG) are used routinely during neurosurgical procedures...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29234872/-multimodal-imaging-in-goldmann-favre-syndrome
#14
D Valler, M Ulbig, C P Lohmann, M Maier
Case report of a 23-year-old male patient suffering from Goldmann-Favre syndrome. The patient reported bilateral visual loss since 10 years of age and difficulties with dark adaptation for 2 years. Until recently a final diagnosis was not found. Multimodal imaging using multicolor fundus imaging (MCFI), optical coherence tomography (OCT), fundus autofluorescence (FAF), fluorescein angiography (FLA), electroretinography (ERG) and visual evoked potential (VEP) confirmed the diagnosis. We describe multimodal imaging of this rare hereditary retinal dystrophy...
December 12, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29234179/vitamin-e-coated-polysulfone-membrane-based-hemodiafiltration-attenuates-inflammation-in-a-rat-model-of-lipopolysaccharide-induced-systemic-inflammation
#15
Yoshihiro Hatanaka, Satoru Inoue, Koji Goto, Norihisa Yasuda, Seigo Hidaka, Takaaki Kitano
Background: Acute blood purification (ABP) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. The present study aimed to determine whether there is a difference in efficacy between polysulfone (PS) membranes, which are currently used regularly in the clinical setting, and vitamin E-coated polysulfone (VEPS) membranes, which are anticipated to exhibit the antioxidant and anti-inflammatory properties of vitamin E...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29197616/the-effect-of-monitor-raster-latency-on-veps-erps-and-brain-computer-interface-performance
#16
Sebastian Nagel, Werner Dreher, Wolfgang Rosenstiel, Martin Spüler
BACKGROUND: Visual neuroscience experiments and Brain-Computer Interface (BCI) control often require strict timings in a millisecond scale. As most experiments are performed using a personal computer (PC), the latencies that are introduced by the setup should be taken into account and be corrected. As a standard computer monitor uses a rastering to update each line of the image sequentially, this causes a monitor raster latency which depends on the position, on the monitor and the refresh rate...
November 29, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29193050/antagonistic-relationship-between-vep-potentiation-and-gamma-power-in-visual-snow-syndrome
#17
Sebastian Luna, Daniel Lai, Alison Harris
OBJECTIVE: Using a "double-pulse" adaptation paradigm, in which two stimuli are presented in quick succession, this study examines the neural mechanisms underlying potentiation of the visual evoked potential (VEP) in visual snow syndrome. BACKGROUND: Visual snow is a persistent visual disturbance characterized by rapid flickering dots throughout the visual field. Like the related condition of migraine with aura, visual snow has been hypothesized to arise from abnormal neuronal responsiveness, as demonstrated by a lack of typical VEP habituation to repeated visual stimulation...
November 29, 2017: Headache
https://www.readbyqxmd.com/read/29190524/four-dimensional-map-of-the-human-early-visual-system
#18
Yasuo Nakai, Akari Nagashima, Akane Hayakawa, Takuya Osuki, Jeong-Won Jeong, Ayaka Sugiura, Erik C Brown, Eishi Asano
OBJECTIVE: We generated a large-scale, four-dimensional map of neuronal modulations elicited by full-field flash stimulation. METHODS: We analyzed electrocorticography (ECoG) recordings from 63 patients with focal epilepsy, and delineated the spatial-temporal dynamics of visually-elicited high-gamma70-110 Hz amplitudes on a standard brain template. We then clarified the neuronal events underlying visual evoked potential (VEP) components, by correlating with high-gamma amplitude measures...
November 27, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29190019/visual-evoked-potentials-in-glaucoma-and-alzheimer-s-disease
#19
Elisa Cerri, Carlotta Fabiani, Chiara Criscuolo, Luciano Domenici
Visual responses to gratings alternating in contrast have been studied in humans and several mammalian species. Previous evidence from human patients and animal models of neurodegeneration has highlighted the importance to record simultaneously the pattern electroretinogram (P-ERG) and visual evoked cortical potentials (VEPs) to investigate retinal and post-retinal sites of neurodegeneration.In view of the increasing importance of research on experimental models of neurodegenerative diseases, we present here the parametric properties of visual evoked responses in animal models of glaucoma and Alzheimer's disease...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29184095/exteroceptive-expectations-modulate-interoceptive-processing-repetition-suppression-effects-for-visual-and-heartbeat-evoked-potentials
#20
Amanda C Marshall, Antje Gentsch, Valentina Jelinčić, Simone Schütz-Bosbach
Interoception refers to the signaling of internal bodily commands. Here, we explore repetition suppression of intero- and exteroceptive neural markers to test whether the perception and predictability of exteroceptive stimulus material affects their expression. Participants completed a repetition suppression paradigm in which angry or neutral facial expressions repeated or alternated. Participants received either an implicit (experiment 1) or explicit (experiment 2) cue enabling the formation of expectations regarding the upcoming facial expression...
November 28, 2017: Scientific Reports
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