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https://www.readbyqxmd.com/read/29150996/the-sep-1-quality-mandate-may-be-harmful-how-to-drown-a-patient-with-30-ml-per-kg-fluid
#1
Paul E Marik, Manu L N G Malbrain
No abstract text is available yet for this article.
November 18, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29142203/mode-of-delivery-and-child-and-adolescent-psychological-well-being-evidence-from-hong-kong-s-children-of-1997-birth-cohort
#2
Cherry Y Leung, Gabriel M Leung, C Mary Schooling
Mode of delivery (vaginal or cesarean section) is thought to affect gut microbiota, which in turn may affect psychological well-being. As such, mode of delivery is potentially a modifiable factor for psychological well-being. Here we examined the association of mode of delivery with child and adolescent psychological well-being. We used multivariable linear regression in a population-representative Hong Kong Chinese birth cohort, "Children of 1997," to examine the adjusted associations of mode of delivery with behavioral problems assessed from parent-reported Rutter score at ~7 (n = 6294) and ~11 years (n = 5598), self-esteem assessed from self-reported Culture-Free Self-Esteem Inventory score at ~11 years (n = 6937) and depressive symptoms assessed from self-reported Patient Health Questionnaire-9 score at ~13 years (n = 5797)...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142195/structural-basis-for-trna-dependent-cysteine-biosynthesis
#3
Meirong Chen, Koji Kato, Yume Kubo, Yoshikazu Tanaka, Yuchen Liu, Feng Long, William B Whitman, Pascal Lill, Christos Gatsogiannis, Stefan Raunser, Nobutaka Shimizu, Akira Shinoda, Akiyoshi Nakamura, Isao Tanaka, Min Yao
Cysteine can be synthesized by tRNA-dependent mechanism using a two-step indirect pathway, where O-phosphoseryl-tRNA synthetase (SepRS) catalyzes the ligation of a mismatching O-phosphoserine (Sep) to tRNA(Cys) followed by the conversion of tRNA-bounded Sep into cysteine by Sep-tRNA:Cys-tRNA synthase (SepCysS). In ancestral methanogens, a third protein SepCysE forms a bridge between the two enzymes to create a ternary complex named the transsulfursome. By combination of X-ray crystallography, SAXS and EM, together with biochemical evidences, here we show that the three domains of SepCysE each bind SepRS, SepCysS, and tRNA(Cys), respectively, which mediates the dynamic architecture of the transsulfursome and thus enables a global long-range channeling of tRNA(Cys) between SepRS and SepCysS distant active sites...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29141374/-association-of-pd-1-tim-3-and-trem-1-single-nucleotide-polymorphisms-with-pulmonary-tuberculosis-susceptibility
#4
F M Wang, X Zhang, L Lan, J M Ji, H B Tang, X J Yao, Y Jiang, J Qian, X G Xu, Q Li, P Yao, J H Li, Y P Shen
Objective: To investigate the association of programmed cell death 1(PD-1), T cell immunoglobulin mucin 3 (TIM-3) and triggering receptor expressed on myeloid cells-1 (TREM-1) genes polymorphisms with pulmonary tuberculosis susceptibility. Methods: In this case-control study, peripheral venous blood of 100 pulmonary tuberculosis patients (pulmonary tuberculosis group) in the Jintan People's Hospital of Changzhou and of community physical examination volunteers (health control group) was collected from Mar 2015 to Sep 2016...
November 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29138091/longitudinal-electrophysiological-changes-after-cervical-hemi-contusion-spinal-cord-injury-in-rats
#5
Zucheng Huang, Rong Li, Junhao Liu, Zhiping Huang, Yong Hu, Xiaoliang Wu, Qingan Zhu
OBJECTIVE: To evaluate the longitudinal somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) characterization from acute to chronic injury following the cervical hemi-contusion spinal cord injury (SCI) in rats, and correlate the MEPs & SEPs to the behavioral outcomes. METHODS: Fifteen adult male Sprague-Dawley rats were subjected to the hemi-contusion spinal cord injury at C5. Forelimb MEPs & SEPs were applied to 5 animals before injury and 3h, 1d, 3d, 1w, 2w, 4w and 8w after injury respectively...
November 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29136360/investigating-socioeconomic-position-in-dental-caries-and-traumatic-dental-injury-among-children-in-quebec
#6
P Da Rosa, Marie-Claude Rousseau, A Edasseri, M Henderson, B Nicolau
OBJECTIVES: Socioeconomic position (SEP) is inversely associated with most oral health outcomes, but the patterns of association may vary depending on the specific outcome. We estimated associations between SEP and two oral health outcomes, dental caries and traumatic dental injuries (TDI), in Quebec children. METHODS: We used data from the baseline visit of the QUALITY (QUebec Adipose and Lifestyle Investigation in Youth) Cohort, an ongoing study in Montreal and Quebec, Canada...
November 10, 2017: Community Dental Health
https://www.readbyqxmd.com/read/29132084/integrated-and-ecosystemic-approaches-for-bridging-the-gap-between-environmental-management-and-port-management
#7
Javier García-Onetti, Marinez E G Scherer, Juan Manuel Barragán
The rapid exploitation of coastal and marine ecosystemic capital is on course to reach a critical point. The difficulty of implementing Integrated and ecosystem based management models, taking into the account the great complexity of the marine socio-ecological systems, has resulted in a significant gap between theory and practice. The majority of authors emphasize difficulties in engaging and convincing private stakeholders and a number of economic sectors involved in these processes. This reticence is traditionally more pronounced in the port sector, despite their important role in the transformation of coastal and marine areas...
November 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29129015/melanoma-inhibition-by-anthocyanins-is-associated-with-the-reduction-of-oxidative-stress-biomarkers-and-changes-in-mitochondrial-membrane-potential
#8
Zoriţa Diaconeasa, Huseyin Ayvaz, Dumitriţa Ruginǎ, Loredana Leopold, Andreea Stǎnilǎ, Carmen Socaciu, Flaviu Tăbăran, Lavinia Luput, Diana Carla Mada, Adela Pintea, Andrew Jefferson
Anthocyanins are water soluble pigments which have been proved to exhibit health benefits. Several studies have investigated their effects on several types of cancer, but little attention has been given to melanoma. The phytochemical content of nine different berry samples was assessed by liquid chromatography followed by electrospray ionization mass spectrometry (LC-ESI(+)-MS). Twenty-six anthocyanins were identified, after a previous C18 Sep-pak clean-up procedure. Chokeberry and red grape anthocyanins rich extracts (C-ARE and RG-ARE) were selected to be tested on normal and melanoma cell lines, due to their different chemical pattern...
November 11, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29123102/semisynthetic-fluorescent-ph-sensors-for-imaging-exocytosis-and-endocytosis
#9
Magalie Martineau, Agila Somasundaram, Jonathan B Grimm, Todd D Gruber, Daniel Choquet, Justin W Taraska, Luke D Lavis, David Perrais
The GFP-based superecliptic pHluorin (SEP) enables detection of exocytosis and endocytosis, but its performance has not been duplicated in red fluorescent protein scaffolds. Here we describe "semisynthetic" pH-sensitive protein conjugates with organic fluorophores, carbofluorescein, and Virginia Orange that match the properties of SEP. Conjugation to genetically encoded self-labeling tags or antibodies allows visualization of both exocytosis and endocytosis, constituting new bright sensors for these key steps of synaptic transmission...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29122298/evoked-potential-and-eeg-study-of-the-neurotoxicity-of-hydramethylnon-in-rats
#10
George M Strain
The objective of the study was to assess the neurotoxicity, using electrodiagnostic tests, of hydramethylnon (Amdro, AC 217,300), an insecticide marketed for the treatment of red imported fire ants, cockroaches, and other insects. Animals were male Fisher 344 albino rats and Long-Evans hooded rats. Brainstem auditory, visual, and somatosensory evoked potentials (BAER, VEP, SEP) and electroencephalograms (EEG) were recorded from implanted screw electrodes before and at multiple time points through day 10 after a single oral dose of hydramethylnon (at 50% or 75% of the LD50) plus vehicle, or vehicle alone...
October 31, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29113612/socioeconomic-inequalities-in-resilience-and-vulnerability-among-older-adults-a-population-based-birth-cohort-analysis
#11
T D Cosco, R Cooper, D Kuh, M Stafford
BACKGROUND: Aging is associated with declines in physical capability; however, some individuals demonstrate high well-being despite this decline, i.e. they are "resilient." We examined socioeconomic position (SEP) and resilience and the influence of potentially modifiable behavioral resources, i.e. social support and leisure time physical activity (LTPA), on these relationships. METHODS: Data came from the Medical Research Council National Survey of Health and Development, a nationally-representative birth cohort study...
November 8, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29112889/challenges-in-the-automated-synthesis-of-18-f-1-fluoroethyl-tryptophan-formation-of-both-o-and-n-alkylated-products
#12
T K Venkatachalam, D H R Stimson, G K Pierens, R Bhalla, D C Reutens
[(18)F]Fluoroethyl tosylate was synthesized using an automated "Synthra" module using ethylene di-tosylate and [(18)F]fluoride/K222/K2CO3 in acetonitrile. [(18)F]Fluoroethyl tosylate was purified by semi-preparative HPLC followed by reformulation using a C18 Sep-Pak cartridge and eluted with DMF. Using this [(18)F]fluoroethyl tosylate, we attempted to alkylate protected tryptophan aiming to obtain the N-[(18)F]fluoroethyl-t-Boc-tryptophan methyl ester. Initial attempts resulted in the formation of the O-alkylated, rather than N-alkylated product...
October 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29110569/beliefs-about-smoking-related-lung-cancer-risk-among-low-socioeconomic-individuals-the-role-of-smoking-experience-and-interpersonal-communication
#13
Mesfin Awoke Bekalu, Sara Minsky, Kasisomayajula Viswanath
INTRODUCTION: Previous research has documented that smoking prevalence is generally high among low socioeconomic groups and that tobacco industries continue to target these population groups. However, little research has investigated the beliefs of individuals with low socioeconomic position (SEP) about the association between smoking and cancer risks. In this study, we examined beliefs about smoking-related lung cancer risk and the role of smoking experience, mass media exposure and health-related interpersonal communication among a sample of low SEP population...
November 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/29110097/geographic-region-socioeconomic-position-and-the-utilisation-of-primary-total-joint-replacement-for-hip-or-knee-osteoarthritis-across-western-victoria-a-cross-sectional-multilevel-study-of-the-australian-orthopaedic-association-national-joint-replacement-registry
#14
Sharon Brennan-Olsen, Sara Vogrin, Kara L Holloway, Richard S Page, Muhammad A Sajjad, Mark A Kotowicz, Patricia M Livingston, Mustafa Khasraw, Sharon Hakkennes, Trish L Dunning, Susan Brumby, Daryl Pedler, Alasdair Sutherland, Svetha Venkatesh, Lana J Williams, Gustavo Duque, Julie A Pasco
Compared to urban residents, those in rural/regional areas often experience inequitable healthcare from specialist service providers. Independent of small between-area differences in utilisation, socially advantaged groups had the greatest uptake of joint replacement. These data suggest low correlation between 'need' vs. 'uptake' of surgery in rural/regional areas. BACKGROUND AND PURPOSE: Compared to urban residents, those in rural and regional areas often experience inequitable healthcare from specialist service providers, often due to geographical issues...
November 6, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29108354/ultrasound-guided-percutaneous-microwave-ablation-assisted-by-three-dimensional-visualization-operative-treatment-planning-system-and-percutaneous-transhepatic-cholangial-drainage-with-intraductal-chilled-saline-perfusion-for-larger-hepatic-hilum-hepatocellular
#15
Xin Li, Jie Yu, Ping Liang, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Shaobo Duan, Jiasheng Zheng
To assess the clinical efficiency of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by three-dimensional (3D) visualization operative treatment planning system and percutaneous transhepatic cholangial drainage with intraductal chilled saline perfusion (PTCD-ICSP) for larger hepatic hilum hepatocellular carcinoma (HH-HCC) (D ≥ 3 cm). The combination therapy was performed in 14 patients from Sep 2011 to May 2017. The major outcomes for assessment were biliary duct complications, local tumor recurrence, distant recurrence and overall survival rates...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103596/simultaneous-determination-of-three-pesticide-adjuvant-residues-in-plant-derived-agro-products-using-liquid-chromatography-tandem-mass-spectrometry
#16
Hui Li, Zejun Jiang, Xiaolin Cao, Hang Su, Hua Shao, Fen Jin, A M Abd El-Aty, Jing Wang
Herein, an accurate and reliable isotope-labelled internal standard method was developed and validated for simultaneous determination of three polar pesticide adjuvants, namely 2-pyrrolidone, N-methyl-2-pyrrolidone, and N-ethyl-2-pyrrolidone in plant-derived agro-products. Matrices, including apple, cabbage, tomato, cucumber, rice, and wheat were extracted with a modified quick, easy, cheap, effective, rugged, and safe "QuEChERS" method and purified with a new clean-up sorbent (Z-Sep). A hydrophilic interaction liquid chromatography column (HILIC), exhibiting a lipophilic-hydrophilic character, was used to separate the three analytes over 10min using liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
November 2, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29095274/comparison-of-the-effects-of-extracorporeal-shock-wave-therapy-and-a-vacuum-erectile-device-on-penile-erectile-dysfunction-a-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Tao Qi, Lei Ye, Bo Wang, Bin Zhang, Jun Chen
BACKGROUND: This randomized clinical trial (October 2012-December 2013) compared extracorporeal shock wave therapy (ESWT) and a vacuum erectile device (VED) for management of erectile dysfunction (ED). METHODS: Consecutive Chinese patients (20-55 years) with ED, abnormal nocturnal penile tumescence and rigidity (NPTR), and international index of erectile function-5 items (IIEF-5) score <22 were randomized to receive ESWT or VED (twice weekly, 4 weeks). Primary outcomes were treatment efficacy and success rate 4 weeks after completion of therapy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29088953/somatosensory-evoked-potentials-in-patients-with-high-grade-aneurysmal-subarachnoid-hemorrhage
#18
Klaus Christian Mende, Mathias Gelderblom, Cindy Schwarz, Patrick Czorlich, Nils Ole Schmidt, Eik Vettorazzi, Jan Regelsberger, Manfred Westphal, Tammam Abboud
OBJECTIVE The aim of this prospective study was to investigate the value of somatosensory evoked potentials (SEPs) in predicting outcome in patients with high-grade aneurysmal subarachnoid hemorrhage (SAH). METHODS Between January 2013 and January 2015, 48 patients with high-grade SAH (Hunt and Hess Grade III, IV, or V) who were admitted within 3 days after hemorrhage were enrolled in the study. Right and left median and tibial nerve SEPs were recorded on Day 3 after hemorrhage and recorded again 2 weeks later...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29077031/social-demography-of-transitional-dietary-patterns-in-thailand-prospective-evidence-from-the-thai-cohort-study
#19
Keren Papier, Susan Jordan, Catherine D'Este, Cathy Banwell, Vasoontara Yiengprugsawan, Sam-Ang Seubsman, Adrian Sleigh
In recent decades, a health-risk transition with changes in diet and lifestyle in low and middle-income countries (LMICs) led to an emergence of chronic diseases. These trends in Southeast Asian LMICs are not well studied. Here, we report on transitional dietary patterns and their socio-demographic predictors in Thai adults. Dietary data in 2015 were from a random sub-sample (N = 1075) of 42,785 Thai Cohort Study (TCS) members who completed all three TCS surveys (2005, 2009, 2013). Principle Component Analysis identified dietary patterns and multivariable linear regression assessed associations (Beta estimates (ß) and confidence intervals (CIs)) between socio-demographic factors and dietary intake pattern scores...
October 27, 2017: Nutrients
https://www.readbyqxmd.com/read/29069091/childhood-socioeconomic-position-and-adult-mental-wellbeing-evidence-from-four-british-birth-cohort-studies
#20
Natasha Wood, David Bann, Rebecca Hardy, Catharine Gale, Alissa Goodman, Claire Crawford, Mai Stafford
BACKGROUND: There is much evidence showing that childhood socioeconomic position is associated with physical health in adulthood; however existing evidence on how early life disadvantage is associated with adult mental wellbeing is inconsistent. This paper investigated whether childhood socioeconomic position (SEP) is associated with adult mental wellbeing and to what extent any association is explained by adult SEP using harmonised data from four British birth cohort studies. METHODS: The sample comprised 20,717 participants with mental wellbeing data in the Hertfordshire Cohort Study (HCS), the MRC National Survey of Health and Development (NSHD), the National Child Development Study (NCDS), and the British Cohort Study (BCS70)...
2017: PloS One
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