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https://www.readbyqxmd.com/read/28944715/balance-training-enhances-motor-coordination-during-a-perturbed-side-step-cutting-task
#1
Anderson Souza Oliveira, Priscila de Brito Silva, Morten Enemark Lund, Dario Farina, Uwe Gustav Kersting
Study Design Controlled laboratory study. Background Balance training (BTR) may improve motor coordination, however little is known about the changes in motor coordination during unexpected perturbations to postural control following BTR. Objectives To study the effects of BTR on motor coordination and knee mechanics during perturbed side-step cutting maneuvers in healthy adults. Methods Twenty-six healthy men were randomly assigned to a training group (TG) or control (CG). Before BTR, subjects performed unperturbed, 90° side-step cutting maneuvers and one unexpected perturbed cut (10-cm translation of a moveable platform)...
September 23, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28942240/cortical-signatures-of-vicarious-tactile-experience-in-four-month-old-infants
#2
Silvia Rigato, Michael J Banissy, Aleksandra Romanska, Rhiannon Thomas, José van Velzen, Andrew J Bremner
The human brain recruits similar brain regions when a state is experienced (e.g., touch, pain, actions) and when that state is passively observed in other individuals. In adults, seeing other people being touched activates similar brain areas as when we experience touch ourselves. Here we show that already by four months of age, cortical responses to tactile stimulation are modulated by visual information specifying another person being touched. We recorded somatosensory evoked potentials (SEPs) in 4-month-old infants while they were presented with brief vibrotactile stimuli to the hands...
September 14, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28941313/different-intervention-strategies-for-preventing-type-2-diabetes-mellitus-in-china-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#3
Bing Pang, Lin-Hua Zhao, Xin-Long Li, Jun Song, Qing-Wei Li, Xing Liao, Shuo Feng, Xi-Yan Zhao, Yu-Jiao Zheng, Xiao-Wen Gou, Qing Ni, Xiao-Lin Tong
Different strategies are increasingly used for early intervention on prediabetes in China, but the effects of these strategies on incident diabetes have not yet been confirmed. This study was to systematically assess the effects of different strategies on preventing diabetes, aimed at Chinese prediabetic subjects. Seven electronic databases were searched to identify eligible trials published from inception to Sep 20, 2016. Randomized controlled trials with a minimum follow-up duration of 6 months were included...
September 23, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28939588/childhood-socioeconomic-position-and-pubertal-onset-in-a-cohort-of-multiethnic-girls-implications-for-breast-cancer
#4
Robert A Hiatt, Susan L Stewart, Kristin S Hoeft, Lawrence H Kushi, Gayle C Windham, Frank M Biro, Susan M Pinney, Mary S Wolff, Susan L Teitelbaum, Dejana Braithwaite
BACKGROUND: Higher socioeconomic position (SEP) has been associated with increased risk of breast cancer. Its relationship with earlier age of pubertal onset, a risk factor for breast cancer, is less clear. METHODS: We studied the relationship of SEP to pubertal onset in multiethnic cohort of 1237 girls aged 6-8 years at baseline. Girls in three U.S. cities were followed for 5-8 years with annual clinical examinations from 2004 to 2012. SEP measures were examined for associations with pubertal onset, assessed by breast budding (thelarche) and pubic hair development (adrenarche)...
September 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28933875/-sex-differences-in-left-handedness-a-meta-analysis-of-144-studies-correction-to-papadatou-pastou-et-al-2008
#5
(no author information available yet)
Reports an error in "Sex differences in left-handedness: A meta-analysis of 144 studies" by Marietta Papadatou-Pastou, Maryanne Martin, Marcus R. Munafò and Gregory V. Jones (Psychological Bulletin, 2008[Sep], Vol 134[5], 677-699). In the article the statistical evidence is weaker than reported for the moderating effect of writing hand compared to all the other instruments (reported finding: Q(1) = 8.36, p = .02; corrected finding: Q(1) = 3.17, p = .075). While the statistical evidence is thus somewhat weaker on this particular point, the broad conclusions of the article remain unchanged...
October 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28926725/association-between-x-ray-repair-cross-complementing-group-1-xrcc1-arg399gln-polymorphism-and-endometriosis-a-systematic-review-and-meta-analysis
#6
Mo-Qi Lv, Jin Wang, Xiao-Qing Yu, Hui-Hui Hong, Wen-Juan Ren, Pang Ge, Dang-Xia Zhou
OBJECTIVE(S): X-ray repair cross-complementing group 1(XRCC1) gene is one of the DNA repair pathway genes playing a vital role in endometriosis risk. Various studies have explored the association between them, however, the results remained inconsistent. So to confirm the association between XRCC1 Arg399Gln polymorphism and the risk of endometriosis, a meta-analysis was conducted. STUDY DESIGN: PubMed, Web of Science, Science Director, Cochrane Library, Google Scholar, China National Knowledge Infrastructure (CNKI) and Wanfang Data databases were searched to identify the all relevant studies before Sep...
September 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28920006/dosing-immunotherapy-combinations-analysis-of-3-526-patients-for-toxicity-and-response-patterns
#7
Mina Nikanjam, Harsh Patel, Razelle Kurzrock
Immunotherapy combinations are used to improve outcomes in metastatic cancer, but evidence-based knowledge of appropriate starting doses for novel combinations is lacking. Phase I-III adult combination clinical trials (≥ 1 drug was immunotherapy; anti-PD-1, PD-L1, or CTLA-4) were reviewed (PubMed Jan 1, 2010 to Sep 1, 2016; ASCO 2014-2016, ASH/ESMO 2014-2015 abstracts). The safe dose for each drug used in each combination was divided by the single-agent recommended dose to calculate dose percentage. Additive dose percentage was the sum of each dose percentage...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28918691/measuring-musculoskeletal-pain-in-infants-children-and-adolescents
#8
Zoe A Michaleff, Steven J Kamper, Jennifer N Stinson, Lise Hestbaek, Chris M Williams, Paul Campbell, Kate M Dunn
Synopsis Accurate, reliable, and timely assessment of pain is critical for effective management of musculoskeletal pain conditions. The assessment of pain in infants, children, and adolescents with and without cognitive impairment can be particularly challenging for clinicians for a number of reasons, including factors related to: the consultation (eg, heterogeneous patient population, time constraints), the clinician (eg, awareness / knowledge of available pain scales), standardised assessment scales (eg, availability, psychometric properties, and application of each scale) the patient (eg, developmental stage, ability to communicate), and the context in which the interaction takes place (eg, familiarity with the setting and physiological and psychological state)...
September 16, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28917044/simultaneous-speciation-of-selenoproteins-and-selenometabolites-in-plasma-and-serum
#9
Belén Callejón-Leblic, Gema Rodríguez-Moro, Tamara García-Barrera, José Luis Gómez-Ariza
Selenium is an essential element incorporated to different proteins with important biological functions in connection to antioxidant activity, cancer-protective properties, neurodegenerative pathologies, and prevention of effects of diabetes, among others. In addition, selenoamino acids play a basic role in the global equilibrium of key selenium-biomolecules synthesis, including selenoprotein P, selenoalbumin, and glutathione peroxidase. Homeostasis of these selenium-containing biomolecules involves different organs in living organisms including human, and bloodstream is the connection fluid in this process...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28915773/does-motor-development-in-infancy-predict-spinal-pain-in-later-childhood-a-cohort-study
#10
Steven J Kamper, Christopher M Williams, Lise Hestbaek
Study Design Longitudinal cohort study. Background Spinal pain is responsible for a huge personal and societal burden but the aetiology remains unclear. Deficits in motor control have been implicated with spinal pain in adults, and delayed motor development is associated with a range of health problems and risks in children. Objectives To assess whether there is an independent relationship between the age at which infants first sit and walk without support, and spinal pain at age 11 years. Methods Data from the Danish National Birth Cohort were analysed...
September 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28915772/hypermobility-in-adolescent-athletes-pain-functional-ability-quality-of-life-and-musculoskeletal-injuries
#11
Heidi Schmidt, Trine Lykke Pedersen, Tina Junge, Raoul Engelbert, Birgit Juul-Kristensen
Study Design Cross-sectional. Background Generalised joint hypermobility (GJH) may increase pain and likelihood of injuries and also decrease function and health-related quality of life (HRQoL) in elite level adolescent athletes. Objectives To assess the prevalence of GJH in elite level adolescent athletes, and to study the association of GJH with pain, function, HRQoL, and musculoskeletal injuries. Methods A total of 132 elite level adolescent athletes (36 males; 96 females), mean (SD) age 14.0 (0.9) years, participated (n=22 ballet dancers, n=57 teamgym gymnasts, n=53 team handball players)...
September 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28915771/low-back-pain-with-impact-at-17-years-of-age-is-predicted-by-early-adolescent-risk-factors-from-multiple-domains-analysis-of-the-western-australian-pregnancy-cohort-raine-study
#12
Anne Smith, Darren Beales, Peter O'Sullivan, Natasha Bear, Leon Straker
Study Design Prospective cohort study of the Western Australian Pregnancy Cohort (Raine) Study. Background Low back pain (LBP) commonly develops in adolescence and is a significant risk factor for adult LBP. A broad range of factors have been associated with the development of adolescent LBP, but prior literature has limitations related to characterisation of LBP and scope of risk factors considered. Objective This study aimed to identify potential factors contributing to the development of LBP with and without impact at 17 years of age, utilising a broad range of exposures at 14...
September 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28915381/adult-vitamin-d-deficiency-exacerbates-impairments-caused-by-social-stress-in-balb-c-and-c57bl-6-mice
#13
Natalie J Groves, Mei Zhou, Dhanisha J Jhaveri, John J McGrath, Thomas H J Burne
Vitamin D deficiency is prevalent in adults throughout the world. Epidemiological studies have shown significant associations between vitamin D deficiency and an increased risk of various neuropsychiatric and neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease and cognitive impairment. However, studies based on observational epidemiology cannot address questions of causality; they cannot determine if vitamin D deficiency is a causal factor leading to the adverse health outcome...
September 6, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28912734/malm%C3%A3-treatment-referral-and-intervention-study-high-12-month-retention-rates-in-patients-referred-from-syringe-exchange-to-methadone-or-buprenorphine-naloxone-treatment
#14
Martin Bråbäck, Lars Ekström, Katja Troberg, Suzan Nilsson, Pernilla Isendahl, Louise Brådvik, Anders Håkansson
BACKGROUND: Heroin dependence is associated with high mortality. Opioid agonist treatment (OAT) with methadone or buprenorphine has strong evidence for treatment of this relapsing condition. In our setting, OAT has been associated with strict and demanding intake procedures, often with requirements of social stability, but also high, approximately 80 percent 12-month retention rates. In a recent randomized controlled trial, we demonstrated high rates of successful rapid referral from a syringe exchange programme (SEP) to treatment with methadone or buprenorphine, including actual treatment initiation...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28912657/moderate-intensity-cycling-exercise-after-upper-extremity-resistance-training-interferes-response-to-muscle-hypertrophy-but-not-strength-gains
#15
Shigeto Tomiya, Naoki Kikuchi, Koichi Nakazato
The purpose of the present study was to examine the effect of 30-min moderate intensity cycling exercise immediately after upper-body resistance training on the muscle hypertrophy and strength gain. Fourteen subjects were randomly divided between two groups. One group performed moderate intensity (55% of maximum oxygen consumption [VO2max], 30 min) cycle training immediately after arm resistance training as concurrent training (CT; n = 7, age: 21.8 ± 0.7 years, height: 1.68 ± 0.06 m, weight: 60.3 ± 7.4 kg); the second group performed the same endurance and arm RT on separate days as control group (SEP; n=7, age: 22...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28910891/-clinical-study-of-aged-patients-with-secondary-benign-paroxysmal-positional-vertigo
#16
Z J Zhu, L P Wei, Z X Xu, H J Xu, Q Liu, N Luo
Objective: To investigate the clinical features and evaluate the efficacy of manual reduction in treatment of age patients with secondary benign paroxysmal positional vertigo (s-BPPV). Methods: Thirty-two cases of aged patients ( the s-BPPV group: including 19 cases of female and 13 males, age from 60 to 86 years old)with secondary benign paroxysmal positional vertigo from Jul. 2013 to Sep. 2015 in our hospital were retrospectively analyzed. The results were compared with 121 patients( the primary group: including 82 cases of female and 39males, aged from 60 to 86 years old)with aged primary benign paroxysmal positional vertigo(p -BPPV)...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28910148/bulk-scale-formulation-of-therapeutic-doses-of-clinical-grade-ready-to-use-177-lu-dota-tate-the-intricate-radiochemistry-aspects
#17
Anupam Mathur, Vrinda Prashant, Navin Sakhare, Sudipta Chakraborty, K V Vimalnath, Repaka Krishna Mohan, Chanda Arjun, Barkha Karkhanis, Ravi Seshan, Sandip Basu, Aruna Korde, Sharmila Banerjee, Ashutosh Dash, Satbir Singh Sachdev
INTRODUCTION: (177)Lu-DOTA-TATE is a clinically useful and promising therapeutic radiopharmaceutical for peptide receptor radionuclide therapy of neuroendocrine tumors (NETs) overexpressing somatostatin receptors. Currently, the radiopharmaceutical is prepared in-house at nuclear medicine centers, thereby restricting its use to limited centers only. In this article, the authors describe systematic studies toward bulk scale formulation of "ready-to-use" (177)Lu-DOTA-TATE using medium specific activity (177)Lu (740-1110 GBq/mg) at a centralized radiopharmacy facility...
September 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28905308/an-automated-multidose-synthesis-of-the-potentiometric-pet-probe-4-18-f-fluorobenzyl-triphenylphosphonium-18-f-fbntp
#18
Christopher M Waldmann, Adrian Gomez, Phillip Marchis, Sean T Bailey, Milica Momcilovic, Anthony E Jones, David B Shackelford, Saman Sadeghi
PURPOSE: The aim of this study was the automated synthesis of the mitochondrial membrane potential sensor 4-[(18)F]fluorobenzyl-triphenylphosphonium ([(18)F]FBnTP) on a commercially available synthesizer in activity yields (AY) that allow for imaging of multiple patients. PROCEDURES: A three-pot, four-step synthesis was implemented on the ELIXYS FLEX/CHEM radiosynthesizer (Sofie Biosciences) and optimized for radiochemical yield (RCY), radiochemical purity (RCP) as well as chemical purity during several production runs (n = 24)...
September 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28898562/skipping-breakfast-among-australian-children-and-adolescents-findings-from-the-2011-12-national-nutrition-and-physical-activity-survey
#19
Kylie J Smith, Monique C Breslin, Sarah A McNaughton, Seana L Gall, Leigh Blizzard, Alison J Venn
OBJECTIVE: Skipping breakfast has been linked with poor diet quality, higher BMI and adverse cardiometabolic outcomes. This study aimed to determine the prevalence and correlates of skipping breakfast among Australian children and adolescents. METHODS: A total of 1,592 2-17-year-olds completed two 24-hour recalls, collected via face-to-face and telephone interview, in the 2011-12 National Nutrition and Physical Activity Survey. Breakfast was an eating occasion of ≥210kJ named as 'breakfast' by the participant...
September 12, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28898490/inclusion-of-equity-in-economic-analyses-of-public-health-policies-systematic-review-and-future-directions
#20
Anita Lal, Marjory Moodie, Anna Peeters, Rob Carter
OBJECTIVES: To assess current approaches to inclusion of equity in economic analysis of public health interventions and to recommend best approaches and future directions. METHODS: We conducted a systematic review of studies that have used socioeconomic position (SEP) in cost-effectiveness analyses. Studies were identified using MedLine, EconLit and HEED and were evaluated based on their SEP specific inputs and methods of quantification of the health and financial inequalities...
September 12, 2017: Australian and New Zealand Journal of Public Health
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