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https://www.readbyqxmd.com/read/28534447/selenium-selenoproteins-and-selenometabolites-in-mothers-and-babies-at-the-time-of-birth
#1
Cristina Santos, Eduardo García-Fuentes, Belén Callejón-Leblic, Tamara García-Barrera, José Luis Gómez-Ariza, Margaret P Rayman, Inés Velasco
The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother-baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC...
May 23, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28533805/electronic-brachytherapy-management-of-atypical-fibroxanthoma-report-of-8-lesions
#2
Stephen Doggett, James Brazil, Marketa Limova, Leah Press, Sidney Smith, Jeremy Peck
PURPOSE: To evaluate the suitability of treating atypical fibroxanthoma (AFX), an uncommon skin malignancy, with electronic brachytherapy. MATERIAL AND METHODS: From Feb 2013 to Sep 2014, we were referred a total of 8 cases of AFX in 7 patients, all involving the scalp. All of them were treated with electronic brachytherapy 50 Kev radiations (Xoft Axxent(®), Fremont, California). All lesions received 40 Gy in two fractions per week with 5mm margins. RESULTS: At a median follow-up of 23...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28531169/expression-of-liver-receptor-homolog-1-lrh-1-in-villi-and-decidua-of-patients-with-unexplained-recurrent-spontaneous-abortion
#3
Zhiyan Xu, Xiangqing Hou, Hongtao Lv, Binghui Sun, Yingying Cui, Ling Liu, Fengnian Rong
BACKGROUND In view of the important function of nuclear receptor liver receptor homolog 1 (LRH 1) in various biological processes and the physiological changes accompanying unexplained recurrent spontaneous abortion (USRA), our study was carried out to investigate the potential roles of LRH-1 in USRA. MATERIAL AND METHODS Thirty patients with URSA at early the early state of pregnancy were selected, and 30 patients with normal early pregnancy were also selected from Aug 2015 to Sep 2016 as a control group. The expression of LRH-1 protein in decidua and villi were detected by immunohistochemistry and Western blot analysis, and the expression of LRH-1 mRNA was detected by RT-PCR...
May 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28528987/mining-for-micropeptides
#4
REVIEW
Catherine A Makarewich, Eric N Olson
Advances in computational biology and large-scale transcriptome analyses have revealed that a much larger portion of the genome is transcribed than was previously recognized, resulting in the production of a diverse population of RNA molecules with both protein-coding and noncoding potential. Emerging evidence indicates that several RNA molecules have been mis-annotated as noncoding and in fact harbor short open reading frames (sORFs) that encode functional peptides and that have evaded detection until now due to their small size...
May 18, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/28523037/frequency-of-dyslipidemia-in-patients-with-lupus-nephritis
#5
Saba Sajjad, Sumaira Farman, Muhammad Ahmed Saeed, Nighat Mir Ahmad, Bilal Azeem Butt
OBJECTIVE: To determine the frequency of dyslipidemia in patients with lupus nephritis and its association with the degree of proteinuria. METHODS: This cross-sectional analytic study included 65 patients who fulfilled the ACR (American College of Rheumatology) criteria for SLE and had renal involvement, presenting to the Division of Rheumatology, Fatima Memorial Hospital (FMH), and Lahore from 21(st) Sep 2016 to 20(th) Dec 2016. After 12 hours overnight fast their blood samples were assessed for total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL)...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521814/access-to-healthcare-insurance-and-healthcare-services-among-syringe-exchange-program-clients-in-massachusetts-qualitative-findings-from-health-navigators-with-the-idu-i-do-care-collaborative
#6
Thomas J Stopka, Marguerite Hutcheson, Ashley Donahue
BACKGROUND: Little is known about access to health insurance among people who inject drugs (PWID) who attend syringe exchange programs (SEPs). The goal of the current study was to assess perceptions of SEP staff, including health navigators and program managers, on access to health insurance and healthcare access among SEP clients following implementation of state and federal policies to enhance universal healthcare access in Massachusetts. METHODS: Between December 2014 and January 2015, we conducted in-depth interviews (n = 14) with SEP staff, including both program managers and health navigators, to assess knowledge, attitudes, and beliefs related to health insurance enrollment and access to enhanced referrals among SEP clients...
May 18, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28512076/considering-the-public-in-public-health-popular-resistance-to-the-smallpox-eradication-programme-in-india
#7
Luke Juran, Jennifer Trivedi, Korine N Kolivras
Public health initiatives, including large-scale vaccination and disease eradication programmes, regularly pit the rights of the individual against broader benefits to society. At times, the public resists such initiatives, with the World Health Organisation's Smallpox Eradication Programme (SEP) in India being a case in point. Here, we critically investigate resistance to smallpox vaccines in India and argue that while the SEP successfully eradicated a global killer; individuals were stripped of human rights through coercion, forcible vaccination and quarantine...
April 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28507944/a-survey-on-phytochemical-composition-and-biological-activity-of-zygophyllum-fabago-from-iran
#8
Saeid Yaripour, Mohammad-Reza Delnavazi, Parina Asgharian, Samira Valiyari, Saeed Tavakoli, Hossein Nazemiyeh
Purpose: Zygophyllum fabago L. (Z. fabago) is a widespread perennial herb which is used as a medicinal plant in traditional medicine of Iran, Turkey and China. The present study was a survey on phytochemical constituents and biological activities of this plant. Methods: Methanolic extract of the roots was fractionated over a C-18 pre-packed cartridge (Sep-pak) and chromatographic separation was performed on a reversed-phase preparative HPLC. Structural elucidation of the isolated compounds was carried out using UV, (1)H-NMR and 13C-NMR spectral analyses...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28498233/wearable-sensor-technology-efficacy-in-peripheral-vascular-disease-wstep-a-randomized-controlled-trial
#9
Pasha Normahani, Richard Kwasnicki, Colin Bicknell, Louise Allen, Mike P Jenkins, Richard Gibbs, Nicholas Cheshire, Ara Darzi, Celia Riga
OBJECTIVE: To evaluate the effect of using wearable activity monitors (WAMs) in patients with intermittent claudication (IC) within a single-center randomized controlled trial. BACKGROUND: WAMs allow users to set daily activity targets and monitor their progress. They may offer an alternative treatment to supervised exercise programs (SEPs) for patients with IC. METHODS: Thirty-seven patients with IC were recruited and randomized into intervention or control group...
May 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28497235/spatiotemporal-dynamics-of-the-cortical-responses-induced-by-a-prolonged-tactile-stimulation-of-the-human-fingertips
#10
Clara Genna, Calogero M Oddo, Chiara Fanciullacci, Carmelo Chisari, Henrik Jörntell, Fiorenzo Artoni, Silvestro Micera
The sense of touch is fundamental for daily behavior. The aim of this work is to understand the neural network responsible for touch processing during a prolonged tactile stimulation, delivered by means of a mechatronic platform by passively sliding a ridged surface under the subject's fingertip while recording the electroencephalogram (EEG). We then analyzed: (i) the temporal features of the Somatosensory Evoked Potentials and their topographical distribution bilaterally across the cortex; (ii) the associated temporal modulation of the EEG frequency bands...
May 11, 2017: Brain Topography
https://www.readbyqxmd.com/read/28494753/preventing-sickness-absenteeism-among-employees-with-common-mental-disorders-or-stress-related-symptoms-at-work-design-of-a-cluster-randomized-controlled-trial-of-a-problem-solving-based-intervention-versus-care-as-usual-conducted-at-the-occupational-health
#11
G Bergström, M Lohela-Karlsson, L Kwak, L Bodin, I Jensen, M Torgén, L Nybergh
BACKGROUND: Common mental disorders (CMDs) are among the leading causes of sick leave in Sweden and other OECD countries. They result in suffering for the individual and considerable financial costs for the employer and for society at large. The occupational health service (OHS) can offer interventions in which both the individual and the work situation are taken into account. The aim of this paper is to describe the design of a study evaluating the effectiveness of an intervention given at the OHS to employees with CMDs or stress-related symptoms at work...
May 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28488087/comparison-of-three-popular-methods-for-recruiting-young-persons-who-inject-drugs-for-interventional-studies
#12
Melissa G Collier, Richard S Garfein, Jazmine Cuevas-Mota, Eyasu H Teshale
Persons who inject drugs (PWID) are at risk for adverse health outcomes as a result of their drug use, and the resulting social stigma makes this a difficult population to reach for interventions aimed at reducing morbidity and mortality. During our study of adult PWID aged ≤40 years living in San Diego during 2009 and 2010, we compared three different sampling methods: respondent-driven sampling (RDS), venue-based sampling at one syringe exchange program (SEP), and street-based outreach. We compared demographic, socioeconomic, health, and behavioral factors and tested participants for HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) and compared across the three methods...
May 9, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28487660/sedentary-behavior-is-only-marginally-associated-with-physical-function-in-adults-aged-40-75-years-the-maastricht-study
#13
Jeroen H P M van der Velde, Hans H C M Savelberg, Julianne D van der Berg, Simone J S Sep, Carla J H van der Kallen, Pieter C Dagnelie, Miranda T Schram, Ronald M A Henry, Petronella L M Reijven, Tineke A C M van Geel, Coen D A Stehouwer, Annemarie Koster, Nicolaas C Schaper
Background: In an aging population, regular physical activity (PA) and exercise have been recognized as important factors in maintaining physical function and thereby preventing loss of independence and disability. However, (older) adults spent the majority of their day sedentary and therefore insight into the consequences of sedentary behavior on physical function, independent of PA, is warranted. Objective: To examine the associations of objectively measured sedentary time (ST), patterns of sedentary behavior, overall PA, and higher intensity PA (HPA) with objective measures of physical function...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28487430/rna-dependent-cysteine-biosynthesis-in-bacteria-and-archaea
#14
Takahito Mukai, Ana Crnković, Takuya Umehara, Natalia N Ivanova, Nikos C Kyrpides, Dieter Söll
The diversity of the genetic code systems used by microbes on earth is yet to be elucidated. It is known that certain methanogenic archaea employ an alternative system for cysteine (Cys) biosynthesis and encoding; tRNA(Cys) is first acylated with phosphoserine (Sep) by O-phosphoseryl-tRNA synthetase (SepRS) and then converted to Cys-tRNA(Cys) by Sep-tRNA:Cys-tRNA synthase (SepCysS). In this study, we searched all genomic and metagenomic protein sequence data in the Integrated Microbial Genomes (IMG) system and at the NCBI to reveal new clades of SepRS and SepCysS proteins belonging to diverse archaea in the four major groups (DPANN, Euryarchaeota, TACK, and Asgard) and two groups of bacteria ("Candidatus Parcubacteria" and Chloroflexi)...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28487133/the-association-between-insulin-use-and-volumetric-bone-mineral-density-bone-micro-architecture-and-bone-strength-of-the-distal-radius-in-patients-with-type-2-diabetes-the-maastricht-study
#15
E A C de Waard, J H M Driessen, J J A de Jong, T A C M van Geel, R M A Henry, H A W van Onzenoort, M T Schram, P C Dagnelie, C J van der Kallen, S J S Sep, C D A Stehouwer, N C Schaper, A Koster, H H C M Savelberg, C Neef, P P M M Geusens, F de Vries, J P W van den Bergh
Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of fractures, despite normal to increased bone mineral density (BMD). Insulin use is one of the factors linked to this increased fracture risk. However, direct negative effects of insulin on bone quality are not expected since insulin is thought to be anabolic to bone. In this cross-sectional study the association between insulin use and volumetric BMD (vBMD), bone micro-architecture and bone strength of the distal radius, as measured with HR-pQCT, was examined...
May 6, 2017: Bone
https://www.readbyqxmd.com/read/28483129/accountability-for-sepsis-treatment-the-sep-1-core-measure
#16
EDITORIAL
Christine A Motzkus, Craig M Lilly
No abstract text is available yet for this article.
May 2017: Chest
https://www.readbyqxmd.com/read/28476112/does-a-deep-seated-l5-vertebra-position-with-respect-to-the-iliac-crests-affect-the-accuracy-of-percutaneous-pedicle-screw-placement-at-lumbosacral-junction
#17
Jing Guo, Lianjin Guo, Juzhou Gao, Qinjie Ling, Zhixun Yin, Erxing He
BACKGROUND: Significant prominence of iliac crests with a deep seated L5 vertebra can potentially interfere with the screw trajectory when placing percutaneous pedicle screws (PPS) at the lumbosacral segment. The objective of this study was to investigate the influence of L5 position in relation to the iliac crests on the accuracy of percutaneous placement of lumbosacral pedicle screws. METHODS: From Oct 2012 to Sep 2014, 54 patients who underwent PPS placement at L5-S1 segment were recruited...
May 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28475042/novel-modeling-of-somatosensory-evoked-potentials-for-the-assessment-of-spinal-cord-injury
#18
Hasan Mir, Hasan Al-Nashash, Jukka Kortelainen, Angelo All
OBJECTIVE: Previous work has shown that differences in the somatosensory evoked potential (SEP) signals between a normal spinal pathway and spinal pathway affected by spinal cord injury (SCI) provide a means to study the degree of injury. This paper proposes a novel quantitative SCI assessment method using time-domain SEP signals. METHODS: A pruned and unstructured fit between SEP signals from a normal spinal pathway and a spinal pathway affected by SCI is developed using methods inspired by recent results in sparse reconstruction theory...
May 2, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28472960/absolute-rather-than-relative-income-is-a-better-socioeconomic-predictor-of-chronic-obstructive-pulmonary-disease-in-swedish-adults
#19
Sten Axelsson Fisk, Juan Merlo
BACKGROUND: While psychosocial theory claims that socioeconomic status (SES), acting through social comparisons, has an important influence on susceptibility to disease, materialistic theory says that socioeconomic position (SEP) and related access to material resources matter more. However, the relative role of SEP versus SES in chronic obstructive pulmonary disease (COPD) risk has still not been examined. METHOD: We investigated the association between SES/SEP and COPD risk among 667 094 older adults, aged 55 to 60, residing in Sweden between 2006 and 2011...
May 4, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28463818/high-frequency-somatosensory-stimulation-increases-sensori-motor-inhibition-and-leads-to-perceptual-improvement-in-healthy-subjects
#20
Lorenzo Rocchi, Roberto Erro, Elena Antelmi, Alfredo Berardelli, Michele Tinazzi, Rocco Liguori, Kailash Bhatia, John Rothwell
OBJECTIVE: High frequency repetitive somatosensory stimulation (HF-RSS), which is a patterned electric stimulation applied to the skin through surface electrodes, improves two-point discrimination, somatosensory temporal discrimination threshold (STDT) and motor performance in humans. However, the mechanisms which underlie these changes are still unknown. In particular, we hypothesize that refinement of inhibition might be responsible for the improvement in spatial and temporal perception...
June 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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