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https://www.readbyqxmd.com/read/29781334/surgical-treatment-of-dystonia
#1
Rubens G Cury, Suneil K Kalia, Binit B Shah, Joohi Jimenez-Shahed, L K Prashanth, Elena Moro
Treatment of dystonia should be individualized and tailored to the specific needs of patients. Surgical treatment is an important option in medically refractory cases. Several issues regarding type of the surgical intervention, targets, and predict factors of benefit are still under debate. Areas covered: To date, several clinical trials have proven the benefit and safety of deep brain stimulation (DBS) for inherited and idiopathic isolated dystonia, whereas there is still insufficient evidence in combined and acquired dystonia...
May 21, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29758099/the-reduction-in-treatment-efficiency-at-high-acoustic-powers-during-mr-guided-transcranial-focused-ultrasound-thalamotomy-for-essential-tremor
#2
Alec Hughes, Yuexi Huang, Michael L Schwartz, Kullervo Hynynen
PURPOSE: To analyze clinical data indicating a reduction in the induced energy-temperature efficiency relationship during transcranial focused ultrasound (FUS) essential tremor (ET) thalamotomy treatments at higher acoustic powers, establish its relationship with the spatial distribution of the focal temperature elevation, and explore its cause. METHODS: A retrospective observational study of patients (N = 19) treated between July 2015-August 2016 for Essential Tremor (ET) by FUS thalamotomy was performed...
May 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29726769/skull-bone-marrow-injury-caused-by-mr-guided-focused-ultrasound-for-cerebral-functional-procedures
#3
Michael L Schwartz, Robert Yeung, Yuexi Huang, Nir Lipsman, Vibhor Krishna, Jennifer D Jain, Martin G Chapman, Andres M Lozano, Kullervo Hynynen
OBJECTIVE One patient for whom an MR-guided focused ultrasound (MRgFUS) pallidotomy was attempted was discovered to have multiple new skull lesions with the appearance of infarcts on the MRI scan 3 months after his attempted treatment. The authors conducted a retrospective review of the first 30 patients treated with MRgFUS to determine the incidence of skull lesions in patients undergoing these procedures and to consider possible causes. METHODS A retrospective review of the MRI scans of the first 30 patients, 1 attempted pallidotomy and 29 ventral intermediate nucleus thalamotomies, was conducted...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29701263/neurological-adverse-event-profile-of-magnetic-resonance-imaging-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#4
Paul S Fishman, W Jeffrey Elias, Pejman Ghanouni, Ryder Gwinn, Nir Lipsman, Michael Schwartz, Jin W Chang, Takaomi Taira, Vibhor Krishna, Ali Rezai, Kazumichi Yamada, Keiji Igase, Rees Cosgrove, Haruhiko Kashima, Michael G Kaplitt, Travis S Tierney, Howard M Eisenberg
BACKGROUND: Magnetic resonance imaging-guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. OBJECTIVE: To determine the safety profile of magnetic resonance imaging-guided focused ultrasound unilateral thalamotomy for essential tremor, including frequency, and severity of adverse events, including serious adverse events...
April 27, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29679783/radiofrequency-lesioning-through-deep-brain-stimulation-electrodes-in-patients-with-generalized-dystonia
#5
Nobuhiko Takeda, Shiro Hoeisawa, Takaomi Taira, Takakazu Kawamata
BACKGROUND: Deep brain stimulation (DBS) is an established treatment for generalized dystonia. However, the DBS device is sometimes removed owing to hardware complications. Here, we present four cases of generalized dystonia treated with radiofrequency lesioning through the DBS electrodes. CASE DESCRIPTION: The patients were three men and one woman (34 to 44 years old). They had undergone DBS for generalized dystonia. However, they subsequently developed complications, such as infection, and removal of the devices became necessary...
April 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29659494/deep-brain-stimulation-of-the-subthalamic-nucleus-in-patients-with-parkinson-disease-with-prior-pallidotomy-or-thalamotomy
#6
Elena A Khabarova, Natalia P Denisova, Aleksandr B Dmitriev, Konstantin V Slavin, Leo Verhagen Metman
Objective. To evaluate the efficacy of deep brain stimulation of the subthalamic nucleus (STN DBS) in patients with Parkinson disease (PD) who previously underwent lesioning of the basal ganglia. Material and methods. The study included 22 patients who underwent STN DBS. Eleven patients had undergone prior unilateral pallidotomy ( n = 6) or VL/VIM thalamotomy ( n = 5) while the other 11 patients had not. The primary outcome was the change from baseline in the motor subscore of the Unified Parkinson Disease Rating Scale (UPDRS-III) 12 months after STN DBS...
April 16, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29582050/assessing-tremor-and-adverse-events-in-patients-with-tremor-dominant-parkinson-disease-undergoing-focused-ultrasound-thalamotomy
#7
Ilana Schlesinger, Alon Sinai, Menashe Zaaroor
No abstract text is available yet for this article.
March 26, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29582048/assessing-tremor-and-adverse-events-in-patients-with-tremor-dominant-parkinson-disease-undergoing-focused-ultrasound-thalamotomy-reply
#8
Aaron E Bond, Binit B Shah, W Jeffrey Elias
No abstract text is available yet for this article.
March 26, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29579287/prospective-tractography-based-targeting-for-improved-safety-of-focused-ultrasound-thalamotomy
#9
Vibhor Krishna, Francesco Sammartino, Punit Agrawal, Barbara K Changizi, Eric Bourekas, Michael V Knopp, Ali Rezai
BACKGROUND: Focused ultrasound thalamotomy (FUS-T) was recently approved for the treatment of refractory essential tremor (ET). Despite its noninvasive approach, FUS-T reinitiated concerns about the adverse effects and long-term efficacy after lesioning. OBJECTIVE: To prospectively assess the outcomes of FUS-T in 10 ET patients using tractography-based targeting of the ventral intermediate nucleus (VIM). METHODS: VIM was identified at the intercommissural plane based on its neighboring tracts: the pyramidal tract and medial lemniscus...
March 21, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29527503/the-potential-value-of-probabilistic-tractography-based-for-mr-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#10
Evangelia Tsolaki, Angela Downes, William Speier, W Jeff Elias, Nader Pouratian
Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due to lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used to localize the lesion. Here, we investigate the potential predictive value of probabilistic tractography guided thalamic targeting by defining how tractography-defined targets, lesion size and location, and clinical outcomes interrelate. MR imaging and clinical outcomes from 12 ET patients that underwent MRgFUS thalamotomy in a pilot study at the University of Virginia were evaluated in this analysis...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29483322/author-response-mri-guided-focused-ultrasound-thalamotomy-in-non-et-tremor-syndromes
#11
Alfonso Fasano, Andres M Lozano
No abstract text is available yet for this article.
February 27, 2018: Neurology
https://www.readbyqxmd.com/read/29483321/reader-response-mri-guided-focused-ultrasound-thalamotomy-in-non-et-tremor-syndromes
#12
Narayanaswamy Venketasubramanian
No abstract text is available yet for this article.
February 27, 2018: Neurology
https://www.readbyqxmd.com/read/29483320/editors-note-mri-guided-focused-ultrasound-thalamotomy-in-non-et-tremor-syndromes
#13
Chafic Karam, Robert C Griggs
No abstract text is available yet for this article.
February 27, 2018: Neurology
https://www.readbyqxmd.com/read/29475059/ventrolateral-motor-thalamus-abnormal-connectivity-in-essential-tremor-before-and-after-thalamotomy-a-resting-state-functional-magnetic-resonance-imaging-study
#14
Constantin Tuleasca, Elena Najdenovska, Jean Régis, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
OBJECTIVE: To evaluate functional connectivity (FC) of the ventrolateral thalamus, a common target for drug-resistant essential tremor (ET), resting-state data were analyzed before and 1 year after stereotactic radiosurgical thalamotomy and compared against healthy controls (HCs). METHODS: In total, 17 consecutive patients with ET and 10 HCs were enrolled. Tremor network was investigated using the ventrolateral ventral (VLV) thalamic nucleus as the region of interest, extracted with automated segmentation from pretherapeutic diffusion magnetic resonance imaging...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29473775/stereotactic-radiosurgery-for-tremor-systematic-review
#15
Nuria E Martínez-Moreno, Arjun Sahgal, Antonio De Salles, Motohiro Hayashi, Marc Levivier, Lijun Ma, Ian Paddick, Jean Régis, Sam Ryu, Ben J Slotman, Roberto Martínez-Álvarez
OBJECTIVE The aim of this systematic review is to offer an objective summary of the published literature relating to stereotactic radiosurgery (SRS) for tremor and consensus guideline recommendations. METHODS This systematic review was performed up to December 2016. Article selection was performed by searching the MEDLINE (PubMed) and EMBASE electronic bibliographic databases. The following key words were used: "radiosurgery" and "tremor" or "Parkinson's disease" or "multiple sclerosis" or "essential tremor" or "thalamotomy" or "pallidotomy...
February 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29433124/thalamic-deep-brain-stimulation-salvages-failed-focused-ultrasound-thalamotomy-for-essential-tremor-a-case-report
#16
Tony R Wang, Robert F Dallapiazza, Shayan Moosa, Diane Huss, Binit B Shah, W Jeffrey Elias
BACKGROUND: A recent randomized controlled trial investigating unilateral MRI-guided focused ultrasound (FUS) for essential tremor demonstrated efficacy. The long-term durability of this thalamotomy, however, is unknown. Furthermore, the feasibility of stimulating a previously lesioned target such as the thalamic nucleus ventralis intermedius (Vim) is poorly understood. We report a case of tremor recurrence, following an initially successful FUS thalamotomy, in which Vim-DBS was subsequently utilized to regain tremor control...
2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29423776/full-recovery-from-drummer-s-dystonia-with-foot-and-arm-symptoms-after-stereotactic-ventro-oral-thalamotomy-a-case-report
#17
Takashi Asahi, Takaomi Taira, Kiyonobu Ikeda, Jiro Yamamoto, Shuji Sato
Ventro-oral (Vo) thalamotomy is effective in patients with focal task-specific dystonias (FTSDs), but only in those with upper-limb symptoms. We describe a patient with drummer's dystonia who completely recovered after Vo thalamotomy. A 37-year-old man who started playing drums at 14 began having difficulty performing fine movements with his right foot when drumming at 22. He experienced right hand cramps while drumming 3 months before visiting our hospital. He was diagnosed with FTSD. Left Vo thalamotomy was performed, which led to complete improvement of symptoms...
April 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29410136/pretherapeutic-functional-imaging-allows-prediction-of-head-tremor-arrest-after-thalamotomy-for-essential-tremor-the-role-of-altered-interconnectivity-between-thalamolimbic-and-supplementary-motor-circuits
#18
Constantin Tuleasca, Jean Régis, Elena Najdenovska, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
OBJECTIVE: To correlate pretherapeutic resting-state functional magnetic resonance imaging (rs-fMRI) measures with pretherapeutic head tremor presence and/or further improvement 1 year after stereotactic radiosurgical thalamotomy (SRS-T) for essential tremor (ET). METHODS: We prospectively collected head tremor scores (range, 0-3) and rs-fMRI data for a cohort of 17 consecutive ET patients in pretherapeutic and 1 year after SRS-T states. We additionally acquired rs-fMRI data for a healthy control (HC) group (n = 12)...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29385928/effects-on-cognition-and-quality-of-life-with-unilateral-magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#19
Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
OBJECTIVE Although neurosurgical procedures are effective treatments for controlling involuntary tremor in patients with essential tremor (ET), they can cause cognitive decline, which can affect quality of life (QOL). The purpose of this study is to assess the changes in the neuropsychological profile and QOL of patients following MR-guided focused ultrasound (MRgFUS) thalamotomy for ET. METHODS The authors prospectively analyzed 20 patients with ET who underwent unilateral MRgFUS thalamotomy at their institute in the period from March 2012 to September 2014...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29385927/preliminary-experience-with-a-transcranial-magnetic-resonance-guided-focused-ultrasound-surgery-system-integrated-with-a-1-5-t-mri-unit-in-a-series-of-patients-with-essential-tremor-and-parkinson-s-disease
#20
Domenico Gerardo Iacopino, Cesare Gagliardo, Antonella Giugno, Giuseppe Roberto Giammalva, Alessandro Napoli, Rosario Maugeri, Francesca Graziano, Francesca Valentino, Giuseppe Cosentino, Marco D'Amelio, Tommaso Vincenzo Bartolotta, Carlo Catalano, Brigida Fierro, Massimo Midiri, Roberto Lagalla
OBJECTIVE Transcranial magnetic resonance-guided focused ultrasound surgery (tcMRgFUS) is one of the emerging noninvasive technologies for the treatment of neurological disorders such as essential tremor (ET), idiopathic asymmetrical tremor-dominant Parkinson's disease (PD), and neuropathic pain. In this clinical series the authors present the preliminary results achieved with the world's first tcMRgFUS system integrated with a 1.5-T MRI unit. METHODS The authors describe the results of tcMRgFUS in a sample of patients with ET and with PD who underwent the procedure during the period from January 2015 to September 2017...
February 2018: Neurosurgical Focus
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