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Thalamotomy

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https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#1
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28298033/diffusion-tractography-imaging-guided-frameless-linear-accelerator-stereotactic-radiosurgical-thalamotomy-for-tremor-case-report
#2
Won Kim, Justin Sharim, Stephen Tenn, Tania Kaprealian, Yvette Bordelon, Nzhde Agazaryan, Nader Pouratian
Essential tremor and Parkinson's disease-associated tremor are extremely prevalent within the field of movement disorders. The ventral intermediate (VIM) nucleus of the thalamus has been commonly used as both a neuromodulatory and neuroablative target for the treatment of these forms of tremor. With both deep brain stimulation and Gamma Knife radiosurgery, there is an abundance of literature regarding the surgical planning, targeting, and outcomes of these methodologies. To date, there have been no reports of frameless, linear accelerator (LINAC)-based thalomotomies for tremor...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298022/magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-tremor-a-report-of-30-parkinson-s-disease-and-essential-tremor-cases
#3
Menashe Zaaroor, Alon Sinai, Dorith Goldsher, Ayelet Eran, Maria Nassar, Ilana Schlesinger
OBJECTIVE Thalamotomy of the ventral intermediate nucleus (VIM) is effective in alleviating medication-resistant tremor in patients with essential tremor (ET) and Parkinson's disease (PD). MR-guided focused ultrasound (MRgFUS) is an innovative technology that enables noninvasive thalamotomy via thermal ablation. METHODS Patients with severe medication-resistant tremor underwent unilateral VIM thalamotomy using MRgFUS. Effects on tremor were evaluated using the Clinical Rating Scale for Tremor (CRST) in patients with ET and by the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS) in patients with PD and ET-PD (defined as patients with ET who developed PD many years later)...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28244011/focused-ultrasound-an-emerging-therapeutic-modality-for-neurologic-disease
#4
Paul S Fishman, Victor Frenkel
Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted through the skull to a brain region selected with real time magnetic resonance imaging and thermography, using a commercial array of focused emitters. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull...
February 27, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28242608/thalamotomy-using-mri-guided-focused-ultrasound-significantly-improves-contralateral-symptoms-and-quality-of-life-in-essential-tremor
#5
Ludvic Zrinzo
No abstract text is available yet for this article.
February 27, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28195357/one-step-backward-magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-the-treatment-of-medically-refractory-tremor
#6
Ron L Alterman
No abstract text is available yet for this article.
March 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28175402/132%C3%A2-a-randomized-sham-controlled-trial-of-transcranial-magnetic-resonance-guided-focused-ultrasound-thalamotomy-trial-for-the-treatment-of-tremor-dominant-idiopathic-parkinson-disease
#7
Aaron E Bond, Robert Dallapiazza, Diane Huss, Amy L Warren, Scott Sperling, Ryder Gwinn, Binit B Shah, W Jeffrey Elias
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28124434/speech-and-language-adverse-effects-after-thalamotomy-and-deep-brain-stimulation-in-patients-with-movement-disorders-a-meta-analysis
#8
REVIEW
Soha Alomar, Nicolas K K King, Joseph Tam, Ausaf A Bari, Clement Hamani, Andres M Lozano
BACKGROUND: The thalamus has been a surgical target for the treatment of various movement disorders. Commonly used therapeutic modalities include ablative and nonablative procedures. A major clinical side effect of thalamic surgery is the appearance of speech problems. OBJECTIVE: This review summarizes the data on the development of speech problems after thalamic surgery. METHODS: A systematic review and meta-analysis was performed using nine databases, including Medline, Web of Science, and Cochrane Library...
January 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28063895/improvement-of-table%C3%A2-tennis-dystonia-by-stereotactic-ventro-oral-thalamotomy-a-case-report
#9
Takashi Asahi, Takaomi Taira, Kiyonobu Ikeda, Jiro Yamamoto, Shuji Sato
BACKGROUND: Task-specific focal dystonia, such as writer's cramp and musician's cramp, is a type of dystonia that affects performance of particular tasks. Such movement disorders have been treated with stereotactic ventro-oral (Vo) thalamotomy with excellent outcomes. However, there has been no previous report of treatment of sport-related or athlete's dystonia by means of stereotactic surgery. We treated a patient with table tennis-related dystonia with Vo thalamotomy, and evaluated the outcome...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28044461/equivalence-of-cell-survival-data-for-radiation-dose-and-thermal-dose-in-ablative-treatments-analysis-applied-to-essential-tremor-thalamotomy-by-focussed-ultrasound-and-gamma-knife
#10
D Schlesinger, M Lee, G Ter Haar, B Sela, M Eames, J Snell, N Kassell, J Sheehan, J M Larner, J-F Aubry
Thermal dose and absorbed radiation dose have historically been difficult to compare because different biological mechanisms are at work. Thermal dose denatures proteins and the radiation dose causes DNA damage in order to achieve ablation. The purpose of this paper is to use the proportion of cell survival as a potential common unit by which to measure the biological effect of each procedure. Survival curves for both thermal and radiation doses have been extracted from previously published data for three different cell types...
January 31, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27959761/a-trial-of-focused-ultrasound-thalamotomy-for-essential-tremor
#11
LETTER
Eng-King Tan, Ling-Ling Chan
No abstract text is available yet for this article.
December 1, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959760/a-trial-of-focused-ultrasound-thalamotomy-for-essential-tremor
#12
LETTER
Ron L Alterman
No abstract text is available yet for this article.
December 1, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959759/a-trial-of-focused-ultrasound-thalamotomy-for-essential-tremor
#13
LETTER
W Jeff Elias
No abstract text is available yet for this article.
December 1, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27903196/the-impact-of-cobalt-60-source-age-on-biologically-effective-dose-in-high-dose-functional-gamma-knife-radiosurgery
#14
Benjamin H Kann, James B Yu, John M Stahl, James E Bond, Christopher Loiselle, Veronica L Chiang, Ranjit S Bindra, Jason L Gerrard, David J Carlson
OBJECTIVE Functional Gamma Knife radiosurgery (GKRS) procedures have been increasingly used for treating patients with tremor, trigeminal neuralgia (TN), and refractory obsessive-compulsive disorder. Although its rates of toxicity are low, GKRS has been associated with some, if low, risks for serious sequelae, including hemiparesis and even death. Anecdotal reports have suggested that even with a standardized prescription dose, rates of functional GKRS toxicity increase after replacement of an old cobalt-60 source with a new source...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27903188/the-role-of-diffusion-tensor-imaging-tractography-for-gamma-knife-thalamotomy-planning
#15
João Gabriel Ribeiro Gomes, Alessandra Augusta Gorgulho, Amanda de Oliveira López, Crystian Wilian Chagas Saraiva, Lucas Petri Damiani, Anderson Martins Pássaro, João Victor Salvajoli, Ludmila de Oliveira Siqueira, Bernardo Peres Salvajoli, Antônio Afonso Ferreira De Salles
OBJECTIVE The role of tractography in Gamma Knife thalamotomy (GK-T) planning is still unclear. Pyramidal tractography might reduce the risk of radiation injury to the pyramidal tract and reduce motor complications. METHODS In this study, the ventralis intermedius nucleus (VIM) targets of 20 patients were bilaterally defined using Iplannet Stereotaxy Software, according to the anterior commissure-posterior commissure (AC-PC) line and considering the localization of the pyramidal tract. The 40 targets and tractography were transferred as objects to the GammaPlan Treatment Planning System (GP-TPS)...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27874491/movement-disorders-in-multiple-sclerosis-and-their-treatment
#16
Günther Deuschl
Hyperkinetic movement disorders such as tremors are not uncommon in patients with multiple sclerosis (MS). The classical feature is intention tremor, whereas rest tremors appear not to occur. Treatment is mainly invasive, with options of Gamma Knife surgery, thalamotomy or deep brain stimulation depending on individual circumstances. Deep brain stimulation is the only option for patients who require a bilateral intervention. All treatment recommendations have only low evidence. Tremors can also be cured spontaneously by a subsequent strategic MS lesion...
December 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27833521/treatment-responsive-holmes-tremor-case-report-and-literature-review
#17
REVIEW
Mohammed Alqwaifly
Holmes tremor is a rare symptomatic movement disorder, characterized by a combination of resting, postural, and action tremors. It is usually caused by lesions involving the brainstem, thalamus, and cerebellum. It is often difficult to treat, many medications have been used with varying degrees of success. It may respond to stereotactic thalamotomy and deep brain stimulation in ventralis intermedius nucleus. Here I report a case of Holmes tremor secondary to multiple sclerosis that treated with L-dopa/carpidopa and showed marked improvement...
October 2016: International Journal of Health Sciences
https://www.readbyqxmd.com/read/27822200/immediate-and-longitudinal-alterations-of-functional-networks-after-thalamotomy-in-essential-tremor
#18
Changwon Jang, Hae-Jeong Park, Won Seok Chang, Chongwon Pae, Jin Woo Chang
Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablation technique, we investigated functional network changes due to a focal lesion. To classify the diverse time courses of those network changes with respect to symptom-related long-lasting treatment effects and symptom-unrelated transient effects, we applied graph-theoretic analyses to longitudinal resting-state functional magnetic resonance imaging data before and 1 day, 7 days, and 3 months after thalamotomy with essential tremor...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27777349/teaching-neuroimages-stroke-mimicking-thalamotomy-cessation-of-tremor-following-ventrolateral-thalamic-ischemia
#19
Andreas Horn, Laura Kipp, Antonio Meola, Andrea A Kühn, Christoph Leithner
No abstract text is available yet for this article.
October 25, 2016: Neurology
https://www.readbyqxmd.com/read/27720703/margin-of-error-for-a-frameless-image-guided-radiosurgery-system-direct-confirmation-based-on-posttreatment-mri-scans
#20
Guozhen Luo, Joseph S Neimat, Anthony Cmelak, Austin N Kirschner, Albert Attia, Manuel Morales-Paliza, George X Ding
PURPOSE: To report on radiosurgery delivery positioning accuracy in the treatment of tremor patients with frameless image guided radiosurgery using the linear accelerator (LINAC) based ExacTrac system and to describe quality assurance (QA) procedures used. METHODS AND MATERIALS: Between 2010 and 2015, 20 patients underwent radiosurgical thalamotomy targeting the ventral intermediate nucleus for the treatment of severe tremor. The median prescription dose was 140 Gy (range, 120-145 Gy) in a single fraction...
August 20, 2016: Practical Radiation Oncology
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