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https://www.readbyqxmd.com/read/29335882/clinical-response-to-vim-s-thalamic-stereotactic-radiosurgery-for-essential-tremor-is-associated-with-distinctive-functional-connectivity-patterns
#1
Constantin Tuleasca, Elena Najdenovska, Jean Régis, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
INTRODUCTION: Essential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard surgical stereotactic procedures (deep brain stimulation, thalamotomy) or minimally invasive high-intensity focused ultrasound (HIFU) or stereotactic radiosurgical thalamotomy (SRS-T). Resting-state fMRI (rs-fMRI) is a non-invasive imaging method acquired in absence of a task. We examined whether rs-fMRI correlates with tremor score on the treated hand (TSTH) improvement 1 year after SRS-T...
January 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29332084/thalamic-deep-brain-stimulation
#2
Benjamin B Whiting, Alexander C Whiting, Donald M Whiting
The use of deep brain stimulation (DBS) of the thalamus has been proven to be a safe and efficacious treatment for the management of many diseases. The most common indication for thalamic DBS remains essential tremor (ET), one of the most common movement disorders in the world. ET patients should be considered for surgical intervention when their tremor has demonstrated to be refractory to medication, a characteristic estimated to be present in roughly 50% of ET cases. Advantages of DBS over thalamotomy include its reversibility, the ability to adjust stimulation settings to optimize efficacy and minimize side effects, the ability to perform bilateral procedures safely, and an association with a lower risk of postoperative cognitive problems...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29332079/radiosurgical-thalamotomy
#3
Edward A Monaco Iii, Samuel S Shin, Ajay Niranjan, L Dade Lunsford
Tremor is a common movement disorder that can be disabling, and its initial treatment is in the form of medical therapies. Often patients are refractory and seek surgical intervention. Treatment options for these patients include surgical radiofrequency thalamotomy and deep brain stimulation. There are a subset of patients who, for various reasons, are not candidates for open surgical procedures, or who opt to avoid them. For these patients, radiosurgical thalamotomy is a safe and useful alternative. Herein, we provide a review of the use of radiosurgical thalamotomy for the treatment of medically refractory tremor by discussing its history, defining the technique and its indications, evaluating its efficacy, and exploring its complications and shortcomings...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29315459/pretherapeutic-functional-neuroimaging-predicts-tremor-arrest-after-thalamotomy
#4
C Tuleasca, E Najdenovska, J Régis, T Witjas, N Girard, J Champoudry, M Faouzi, J-P Thiran, M Bach Cuadra, M Levivier, D Van De Ville
OBJECTIVE: Essential tremor (ET) represents the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic procedures (deep brain stimulation or radiofrequency thalamotomy) or alternatively minimally invasive high-focused ultrasound or radiosurgery. All aim at same target, thalamic ventro-intermediate nucleus (Vim). METHODS: The study included a cohort of 17 consecutive patients, with ET, treated only with left unilateral stereotactic radiosurgical thalamotomy (SRS-T) between September 2014 and August 2015...
January 7, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29286434/mri-guided-focused-ultrasound-thalamotomy-for-patients-with-medically-refractory-essential-tremor
#5
Ying Meng, Yuexi Huang, Benjamin Solomon, Kullervo Hynynen, Nadia Scantlebury, Michael L Schwartz, Nir Lipsman
Essential tremor (ET) is the most common type of tremor in adults. While ET does not result in decreased life expectancy, the disabilities associated with ET can have a significant impact on quality of life, mood, functional activities, and socialization. Patients suffering from ET not sufficiently treated with first line medications may be eligible for alternative strategies such as deep brain stimulation, radiofrequency ablation, and MRI guided focused ultrasound (MRgFUS). High-intensity MRgFUS is an emerging modality to treat ET, its attraction for patients being that it is noninvasive and associated with short recovery time, as patients are home the day after treatment...
December 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29239020/successful-treatment-of-task-specific-lower-extremity-dystonia-by-ventro-oral-thalamotomy
#6
Shiro Horisawa, Kotaro Kohara, Takakazu Kawamata, Takaomi Taira
No abstract text is available yet for this article.
December 14, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29227251/-stereotactic-thalamotomy-and-contralateral-subthalamotomy-in-treatment-of-parkinson-s-disease
#7
K Kostiuk, V Lomadze, N Vasyliv
Aim - to evaluate the efficacy of combined bilateral stereotactic destruction of subcortical nucleus - thalamotomy and contralateral subthalamotomy in patients with Parkinson disease. The study included 10 patients with PD, aged 54-73 (mean age 61.1±5.2 years). The time between two surgeries ranged from 1 to 5 years (mean 2.5±0.5 years). The surgeries were conducted on CRW Radionics stereotactic system using StereoPlan, Atlas (Radionics) andFraimLink (Medtronic) software for target calculating. The neuropsychological status was assessed by UPDRS II, Hoehn and Yahr scale, Schwab and England scale, MMSE...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29194808/the-changing-landscape-of-surgery-for-parkinson-s-disease
#8
REVIEW
Christopher S Lozano, Joseph Tam, Andres M Lozano
Neurosurgical interventions have been used to treat PD for over a century. We examined the changing landscape of surgery for PD to appraise the value of various procedures in the context of advances in our understanding and technology. We assessed the number of articles published on neurosurgical procedures for PD over time as an albeit imprecise surrogate for their usage level. We identified over 8,000 publications associated with PD surgery. Over half the publications were on DBS. The field of DBS for PD showed a rapid rise in articles, but is now in a steady state...
November 30, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29128955/right-brodmann-area-18-predicts-tremor-arrest-after-vim-radiosurgery-a-voxel-based-morphometry-study
#9
Constantin Tuleasca, Tatiana Witjas, Dimitri Van de Ville, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Eric Guedj, Jean Régis
INTRODUCTION: Drug-resistant essential tremor (ET) can benefit from open standard stereotactic procedures, such as deep-brain stimulation or radiofrequency thalamotomy. Non-surgical candidates can be offered either high-focused ultrasound (HIFU) or radiosurgery (RS). All procedures aim to target the same thalamic site, the ventro-intermediate nucleus (e.g., Vim). The mechanisms by which tremor stops after Vim RS or HIFU remain unknown. We used voxel-based morphometry (VBM) on pretherapeutic neuroimaging data and assessed which anatomical site would best correlate with tremor arrest 1 year after Vim RS...
November 11, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29101536/vib-bracelet-a-passive-absorber-for-attenuating-forearm-tremor
#10
Eran Buki, Reuven Katz, Miriam Zacksenhouse, Ilana Schlesinger
Tremor is a rhythmic, involuntary, oscillatory movement of a limb produced by alternating contractions of reciprocally innervated muscles. More than 4% of the population over 40 years old suffer from tremor. There is no cure for most tremors, and while psychological therapy is sometimes helpful, tremors are usually treated with either medication or invasive surgery including thalamotomy and deep brain stimulation. Both medications and surgery may have adverse effects, and thus, there is a growing interest in developing non-invasive vibration attenuation devices...
November 4, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29100066/neuronal-activity-patterns-in-the-ventral-thalamus-comparison-between-parkinson-s-disease-and-cervical-dystonia
#11
Dmitriy Devetiarov, Ulia Semenova, Svetlana Usova, Alexey Tomskiy, Vladimir Tyurnikov, Dinara Nizametdinova, Artem Gushcha, Elena Belova, Alexey Sedov
OBJECTIVE: The aim of this study was to distinguish neuronal activity patterns in the human ventral thalamus and reveal common and disease-specific features in patients with Parkinson's disease (PD) and cervical dystonia (CD). METHODS: Single unit activity of neurons was recorded during microelectrode-guided thalamotomies. We classified neurons of surgical target and surrounding area into patterns and compared their characteristics and responsiveness to voluntary movement between PD and CD patients...
December 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29084313/safety-and-efficacy-of-focused-ultrasound-thalamotomy-for-patients-with-medication-refractory-tremor-dominant-parkinson-disease-a-randomized-clinical-trial
#12
Aaron E Bond, Binit B Shah, Diane S Huss, Robert F Dallapiazza, Amy Warren, Madaline B Harrison, Scott A Sperling, Xin-Qun Wang, Ryder Gwinn, Jennie Witt, Susie Ro, W Jeffrey Elias
Importance: Clinical trials have confirmed the efficacy of focused ultrasound (FUS) thalamotomy in essential tremor, but its effectiveness and safety for managing tremor-dominant Parkinson disease (TDPD) is unknown. Objective: To assess safety and efficacy at 12-month follow-up, accounting for placebo response, of unilateral FUS thalamotomy for patients with TDPD. Design, Setting, and Participants: Of the 326 patients identified from an in-house database, 53 patients consented to be screened...
December 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29054781/superselective-thalamotomy-in-the-most-lateral-part-of-the-ventralis-intermedius-nucleus-for-controlling-essential-and-parkinsonian-tremor
#13
Masafumi Hirato, Takaaki Miyagishima, Akio Takahashi, Yuhei Yoshimoto
OBJECTIVE: The minimum and essential thalamic areas for reducing tremor were investigated in cases treated by superselective thalamotomy in the most lateral part of ventralis intermedius nucleus (mlp-VIM). METHODS: Stereotactic superselective VIM thalamotomy with depth microrecording was performed in 21 patients with essential tremor (ET) and 15 patients with tremor-dominant Parkinson's disease (PD). A very small and narrow (axial plane) therapeutic lesion was formed as a square on the sagittal plane and inverse V on the axial plane in the mlp-VIM, which covered the kinesthetic response area topographically related to tremor...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29053074/clinical-improvement-associated-with-targeted-interruption-of-the-cerebellothalamic-tract-following-mr-guided-focused-ultrasound-for-essential-tremor
#14
J Levi Chazen, Harini Sarva, Philip E Stieg, Robert J Min, Douglas J Ballon, Kane O Pryor, Paul M Riegelhaupt, Michael G Kaplitt
OBJECTIVE The objective of this study was to evaluate the utility of diffusion tensor imaging (DTI) tractography-based targeting of the dentatorubrothalamic tract (DRT) for magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in patients with essential tremor (ET) and correlate postprocedural tract disruption with clinical outcomes. METHODS Four patients received preprocedural and immediate postprocedural DTI in addition to traditional anatomical MRI sequences for MRgFUS thalamotomy. Optimal ablation sites were selected based on the patient-specific location of the DRT as demonstrated by DTI (direct targeting) and correlated with traditional atlas-based measurements for thalamic ventral intermediate nucleus (Vim) lesioning (indirect targeting)...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28942466/assessing-the-clinical-outcome-of-vim-radiosurgery-with-voxel-based-morphometry-visual-areas-are-linked-with-tremor-arrest
#15
Constantin Tuleasca, Tatiana Witjas, Elena Najdenovska, Antoine Verger, Nadine Girard, Jerome Champoudry, Jean-Philippe Thiran, Dimitri Van de Ville, Meritxell Bach Cuadra, Marc Levivier, Eric Guedj, Jean Régis
INTRODUCTION: Radiosurgery (RS) is an alternative to open standard stereotactic procedures (deep-brain stimulation or radiofrequency thalamotomy) for drug-resistant essential tremor (ET), aiming at the same target (ventro-intermediate nucleus, Vim). We investigated the Vim RS outcome using voxel-based morphometry by evaluating the interaction between clinical response and time. METHODS: Thirty-eight patients with right-sided ET benefited from left unilateral Vim RS...
November 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28904473/surgical-interventions-for-task-specific-dystonia-writer-s-dystonia
#16
Paresh K Doshi, Raghvendra Vijay Ramdasi, Bharati Karkera, Dilraj B Kadlas
OBJECTIVES: Writer's cramp is a focal dystonia producing abnormal postures during selective motor activities. Thalamotomy or globus pallidus internus deep brain stimulation (GPi DBS) has been used as a surgical treatment in patients not responding to medical treatment. MATERIALS AND METHODS: Eight patients (all men, age 16-47 years) with refractory focal hand dystonia underwent either ventrooralis (Vo) thalamotomy (seven patients) or GPi DBS (one patient) using stereotactic techniques...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28869946/stereotactic-radiosurgery-for-intractable-tremor-dominant-parkinson-disease-a-retrospective-analysis
#17
Sudesh S Raju, Ajay Niranjan, Edward A Monaco Iii, John C Flickinger, L Dade Lunsford
OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory Parkinson disease (PD) tremor. METHODS: We retrospectively studied the outcomes of 33 patients who were treated with gamma knife thalamotomy (GKT) over a 19-year period. Twelve patients were ≥80 years. A median dose of 140 Gy (range, 130-150 Gy) was delivered to the nucleus ventralis intermedius through a single 4-mm isocenter...
September 2, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28862542/letter-to-the-editor-magnetic-resonance-guided-focused-ultrasound-thalamotomy-for-parkinson-s-disease
#18
Martin Chapman, Jordan Tarshis
No abstract text is available yet for this article.
September 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28818305/treatment-of-the-ventral-intermediate-nucleus-for-medically-refractory-tremor-a-cost-analysis-of-stereotactic-radiosurgery-versus-deep-brain-stimulation
#19
Shearwood McClelland, Jerry J Jaboin
INTRODUCTION: Medically refractory tremor treatment has evolved over the past half-century from intraoperative thalamotomy to deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM). Within the past 15years, unilateral radiosurgical VIM thalamotomy has emerged as a comparably efficacious treatment modality. METHODS: An extensive literature search of VIM DBS series was performed; the total cost of VIM DBS was calculated from hospitals geographically representative of the entire United States using current procedural terminology and work relative value unit (RVU) codes...
August 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28817495/nursing-management-of-the-patient-undergoing-focused-ultrasound-a-new-treatment-option-for-essential-tremor
#20
Katherine Dale Shaw, Amy Sue Johnston, Shelly Rush-Evans, Susan Prather, Kathy Maynard
Essential tremor (ET) is among the most common neurological movement disorders that causes postural or action tremors, with an estimated prevalence nationwide of less than 3% of the population. The incidence of ET increases with age but often affects younger adults and has a familial trait association. Depending on disease progression, ET can cause significant limitations for individuals, in many cases, significantly limiting their ability to perform activities of daily living and occupational responsibilities...
October 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
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