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Depression, mood disorder, bipolar

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https://www.readbyqxmd.com/read/29141103/risk-profiles-of-personality-traits-for-suicidality-among-mood-disorder-patients-and-community-controls
#1
M-H Su, H-C Chen, M-L Lu, J Feng, I-M Chen, C-S Wu, S-W Chang, P-H Kuo
OBJECTIVE: To examine the associations between personality traits and suicidal ideation (SI) and attempt (SA) in mood disorder patients and community controls. METHOD: We recruited 365 bipolar, 296 major depressive disorder patients, and 315 community controls to assess their lifetime suicidality. Participants filled out self-reported personality questionnaires to collect data of personality traits, including novelty seeking (NS), harm avoidance (HA), extraversion (E), and neuroticism (N)...
November 15, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29137178/antidepressants-and-mood-stabilizers-novel-research-avenues-and-clinical-insights-for-bipolar-depression
#2
REVIEW
In Hee Shim, Young Sup Woo, Moon-Doo Kim, Won-Myong Bahk
The concept of the bipolar-spectrum and of mixed features being a bridge between major depressive disorders and bipolar disorders (BDs) has become increasingly important in mood-disorder diagnoses. Under these circumstances, antidepressants (ADs) and mood stabilizers (MSs) should be used with caution in the treatment of major depressive episodes (MDEs) and to obtain long-term stability in BDs. Before treating MDEs, screening tools, specific symptom evaluation and medical history should be used to distinguish between bipolarity and mixed features in patients for whom AD monotherapy may present a risk...
November 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29136600/effects-of-venlafaxine-versus-lithium-monotherapy-on-quality-of-life-in-bipolar-ii-major-depressive-disorder-findings-from-a-double-blind-randomized-controlled-trial
#3
Lorenzo Lorenzo-Luaces, Jay D Amsterdam
Bipolar disorder is associated with decreased quality of life, especially during depressive episodes. There are few studies that have examined whether quality of life improves following pharmacological treatments of bipolar depression. In this exploratory study, we examined the effects of antidepressant versus mood stabilizer monotherapy on quality of life ratings in bipolar II subjects during acute (12 week) treatment. Data were derived from a randomized double-blind comparison of venlafaxine (n = 65) versus lithium (n = 64) monotherapy...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29128113/measurement-equivalence-of-the-bdsx-scale-with-young-and-older-adults-with-bipolar-disorder
#4
Norm O'Rourke, Yaacov G Bachner, Sarah L Canham, Andrew Sixsmith, Badas Study Team
Instruments developed for mental health research are commonly devised and validated with young adults only. However, the measurement properties of these scales may differ over the lifespan. For this study, we set out to demonstrate the psychometric equivalence of the BDSx scale with an international sample of young and older adults with bipolar disorder (BD). We independently replicated the 4-factor model of BDSx responses with young and older participants (M = 45.63, range 19-87 years of age); we then compared the psychometric properties between models...
October 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29122639/the-p2rx7-polymorphism-rs2230912-is-associated-with-depression-a-meta-analysis
#5
D Czamara, B Müller-Myhsok, S Lucae
Various studies have investigated whether single nucleotide polymorphisms (SNPs) in the gene purinergic receptor P2X7 (P2RX7), and rs2230912 specifically, were associated with mood disorders. While some studies found positive evidence, a large number of studies reported no significant associations. In a previously published meta-analysis, Feng et al. did not find a significant association and only moderate odds ratios (ORs) in case-control studies. They reported significant findings only for family-based studies...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29121879/hypnotic-susceptibility-and-affective-states-in-bipolar-i-and-ii-disorders
#6
Bingren Zhang, Jiawei Wang, Qisha Zhu, Guorong Ma, Chanchan Shen, Hongying Fan, Wei Wang
BACKGROUND: Highly hypnotizable individuals have impaired executive function, elevated motor impulsivity and increased emotional sensitivity, which are sometimes found in bipolar disorder patients. It is then reasonable to assume that certain aspects of hypnotic susceptibility differ with the types of bipolar disorder. METHODS: The Stanford Hypnotic Susceptibility Scale: Form C (SHSS:C) test, the Mood Disorder Questionnaire (MDQ), the Hypomanic Checklist-32 (HCL-32) and the Plutchick-van Praag Depression Inventory (PVP) were applied to 62 patients with bipolar I disorder, 33 bipolar II disorder, and 120 healthy volunteers...
November 9, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29121444/neurocognitive-functioning-clinical-course-and-functional-outcome-in-first-treatment-bipolar-i-disorder-patients-with-and-without-clinical-relapse-a-1-year-follow-up-study
#7
Christine Demmo, Trine V Lagerberg, Levi R Kvitland, Sofie R Aminoff, Tone Hellvin, Carmen Simonsen, Beathe Haatveit, Ole A Andreassen, Ingrid Melle, Torill Ueland
OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established...
November 9, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29119914/obsessive-compulsive-disorder-with-comorbid-bipolar-disorders-clinical-features-and-treatment-implications
#8
Federico Mucci, Cristina Toni, Ettore Favaretto, Giulia Vannucchi, Donatella Marazziti, Giulio Perugi
BACKGROUND: Obsessive-compulsive disorder (OCD) symptoms within the context of a bipolar disorder (BD) have been described since the 19th century. Interestingly, the existence of a relevant overlap between the aforementioned psychiatric syndromes has been confirmed by a number of recent epidemiological and family studies. AIMS: The aim of the present paper is to review the clinical features and the therapeutic implications of the OCD-BD comorbidity. DISCUSSION: In the last two decades, the frequent association between OCD and BD has been earning a growing interest given its relevant nosological and therapeutic implications...
November 8, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29112195/face-and-predictive-validity-of-the-clock%C3%AE-19-mouse-as-an-animal-model-for-bipolar-disorder-a-systematic-review
#9
REVIEW
M Kristensen, A A Nierenberg, S D Østergaard
Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (ClockΔ19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We carried out a systematic search of the databases PubMed and Embase, combining search terms covering BD and ClockΔ19...
November 7, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29102411/what-can-mitochondrial-dna-analysis-tell-us-about-mood-disorders
#10
REVIEW
Takaoki Kasahara, Tadafumi Kato
Variants in mitochondrial DNA (mtDNA) and nuclear genes encoding mitochondrial proteins in bipolar disorder, depression, or other psychiatric disorders have been studied for decades, since mitochondrial dysfunction was first suggested in the brains of patients with these diseases. Candidate gene association studies initially resulted in findings compatible with the mitochondrial dysfunction hypothesis. Many of those studies, however, were conducted with modest sample sizes (N < 1000), which could cause false positive findings...
September 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29100629/metabotropic-glutamatergic-receptor-5-and-stress-disorders-knowledge-gained-from-receptor-imaging-studies
#11
REVIEW
Irina Esterlis, Sophie E Holmes, Priya Sharma, John H Krystal, Christine DeLorenzo
The metabotropic glutamatergic receptor subtype 5 (mGluR5) may represent a promising therapeutic target for stress-related psychiatric disorders. Here, we describe mGluR5 findings in stress disorders, particularly major depressive disorder (MDD), highlighting insights from positron emission tomography studies. Positron emission tomography studies report either no differences or lower mGluR5 in MDD, potentially reflecting MDD heterogeneity. Unlike the rapidly acting glutamatergic agent ketamine, mGluR5-specific modulation has not yet shown antidepressant efficacy in MDD and bipolar disorder...
September 19, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29096909/-assessment-of-mood-disorders-by-passive-data-gathering-the-concept-of-digital-phenotype-versus-psychiatrist-s-professional-culture
#12
A Bourla, F Ferreri, L Ogorzelec, C Guinchard, S Mouchabac
OBJECTIVES: The search for objective clinical signs is a constant practitioners' and researchers' concern in psychiatry. New technologies (embedded sensors, artificial intelligence) give an easier access to untapped information such as passive data (i.e. that do not require patient intervention). The concept of "digital phenotype" is emerging in psychiatry: a psychomotor alteration translated by accelerometer's modifications contrasting with the usual functioning of the subject, or the graphorrhea of patients presenting a manic episode which is replaced by an increase of SMS sent...
October 30, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29096128/are-comorbid-anxiety-disorders-a-risk-factor-for-suicide-attempts-in-patients-with-mood-disorders-a-two-year-prospective-study
#13
L N Abreu, M A Oquendo, H Galfavy, A Burke, M F Grunebaum, L Sher, G M Sullivan, M E Sublette, J Mann, B Lafer
BACKGROUND: Comorbid anxiety disorders have been considered a risk factor for suicidal behavior in patients with mood disorders, although results are controversial. The aim of this two-year prospective study was to determine if lifetime and current comorbid anxiety disorders at baseline were risk factors for suicide attempts during the two-year follow-up. METHODS: We evaluated 667 patients with mood disorders (504 with major depression and 167 with bipolar disorder) divided in two groups: those with lifetime comorbid anxiety disorders (n=229) and those without (n=438)...
September 29, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29079138/a-homer-1-gene-variant-influences-brain-structure-and-function-lithium-effects-on-white-matter-and-antidepressant-response-in-bipolar-disorder-a-multimodal-genetic-imaging-study
#14
Francesco Benedetti, Sara Poletti, Clara Locatelli, Elena Mazza, Cristina Lorenzi, Alice Vitali, Martina Riberto, Silvia Brioschi, Benedetta Vai, Irene Bollettini, Elisa Melloni, Veronica Aggio, Andrea Falini, Andrea De Bartolomeis, Cristina Colombo
BACKGROUND: The Homer family of postsynaptic scaffolding proteins plays a crucial role in glutamate-mediated synaptic plasticity, a phenotype associated with Bipolar Disorder (BD). Homer is a target for antidepressants and mood stabilizers. The AA risk genotype of the Homer rs7713917 A>G SNP has been associated with mood disorders and suicide, and in healthy humans with brain function. Despite the evidence linking Homer 1 gene and function to mood disorder, as well as its involvement in animal models of depression, no study has yet investigated the role of Homer in bipolar depression and treatment response...
October 27, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29077652/self-harm-affective-traits-and-psychosocial-functioning-in-adults-with-depressive-and-bipolar-disorders
#15
Marc J Weintraub, Margaret M Van de Loo, Michael J Gitlin, David J Miklowitz
Self-harm refers to the purposeful destruction of bodily tissue without suicidal intention and for purposes that are not socially sanctioned. Little is known about the associations between a history of self-harm, mood symptoms, and functioning in adults with different types of mood disorders. Lifetime histories of self-harm, current mood symptoms, global functioning, and affective traits were collected on 142 adults with mood disorders. The prevalence of lifetime self-harm was higher in patients with bipolar disorder compared with patients with a unipolar depressive disorder...
November 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29073747/psychometric-properties-of-the-hypomania-checklist-32-in-korean-patients-with-mood-disorders
#16
Bo-Hyun Yoon, Jules Angst, Won-Myong Bahk, Hee Ryung Wang, Seung-Oh Bae, Moon-Doo Kim, Young-Eun Jung, Kyung Joon Min, Hwang-Bin Lee, Seunghee Won, Jeongwan Hong, Myong Su Choi, Duk-In Jon, Young Sup Woo
Objective: The aim of this study was to examine the validity of the Korean version of the Hypomania Checklist-32, second revision (HCL-32-R2) in mood disorder patients. Methods: A total of 454 patients who diagnosed as mood disorder according to Structured Clinical Interview for DSM-IV Axis I Disorders, clinician version (SCID-CV) (bipolar disorder [BD] I, n=190; BD-II, n=72; and major depressive disorder [MDD], n=192) completed the Korean module of the HCL-32-R2 (KHCL-32-R2)...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29073533/planned-and-unplanned-complex-suicides-casuistry-of-the-institute-of-legal-medicine-of-parma-italy
#17
Antonio Banchini, Maria Laura Schirripa, Luca Anzillotti, Rossana Cecchi
Complex suicide is performed using more harmful methods, simultaneously or consecutively. In these cases, the distinction between suicide and homicide represents a challenge for forensic pathologists. In literature, complex suicide is divided in two subgroups: "planned complex suicide" or "unplanned complex suicide" depending from forensic features and often related to psychiatric variables. Aim of this study was to show the casuistry of complex suicide in Parma's Forensic service analyzing, for each case, the forensic medical problems (type and site of lesions on the body), and the supplementary data [Police's inspection report, toxicological analysis and psychiatric anamnesis (when available)], trying, through a multidisciplinary approach, to determine a possible correlation between the victim's mood and suicide's method chosen, whether planned or unplanned...
October 13, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29072179/the-role-of-chronobiology-as-transdisciplinary-field-of-research-application-to-psychiatry
#18
Okan Çalıyurt
Chronobiology is a field that studies the effects of time on biological systems. Periodicity is of particular interest. The master biological clock in the suprachiasmatic nucleus controls daily rhythms of core body temperature, rest-activity cycle, physiological and behavioral functions, psychomotor functions and mood in humans. The clock genes are involved in the generation of the circadian rhythms and the biological clock is synchronized to solar day by direct photic inputs. Various circadian rhythm abnormalities have been demonstrated in mood disorders such as unipolar depression, bipolar depression and seasonal affective disorder...
October 26, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29069624/patterns-of-cannabis-use-and-clinical-correlates-among-individuals-with-major-depressive-disorder-and-bipolar-disorder
#19
Sharon Taub, Daniel Feingold, Jürgen Rehm, Shaul Lev-Ran
BACKGROUND: Major Depressive Disorder (MDD) and Bipolar Disorder (BPD) are the most severe mood disorders globally. Previous reports indicate high co-occurrence of cannabis use and cannabis use disorders (CUDs) associated with both disorders, yet studies comparing patterns of cannabis use between individuals with MDD and BPD are scarce. METHODS: Data were drawn from Wave 1 (2001-2002) of the National Epidemiologic survey on Alcohol and Related Conditions (NESARC)...
September 13, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29063592/omega-3-supplementation-associated-with-improved-parent-rated-executive-function-in-youth-with-mood-disorders-secondary-analyses-of-the-omega-3-and-therapy-oats-trials
#20
Anthony T Vesco, Andrea S Young, L Eugene Arnold, Mary A Fristad
BACKGROUND: Improvements in executive functioning (EF) may lead to improved quality of life and lessened functional impairment for children with mood disorders. The aim was to assess the impact of omega-3 supplementation (Ω3) and psychoeducational psychotherapy (PEP), each alone and in combination, on EF in youth with mood disorders. We completed secondary analyses of two randomized controlled trials (RCTs) of Ω3 and PEP for children with depression and bipolar disorder. METHODS: Ninety-five youths with depression or bipolar disorder not otherwise specified/cyclothymic disorder were randomized in 12-week RCTs...
October 24, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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