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intra uterine injection HCG

Semih Zeki Uludag, Mehmet Serdar Kutuk, Mehmet Dolanbay, Mahmut Tuncay Ozgun, Gunel Eliyeva, Ozguc Altun
The aim of this study was to compare the effect of local intracavitary methotrexate (MTX) injection and laparoscopic (L/S) cornuostomy in the treatment of interstitial pregnancy (IP) in terms of clinical and reproductive outcome. The data of patients with IP (n:10) who were treated between September 2011 and December 2016 with either an intra-amniotic MTX injection (n:7) or L/S cornuostomy (n:3) were retrospectively evaluated. All cases (7/7) in the local injection group and two (2/3) in the L/S group were successfully treated with the initial treatment...
March 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Juan Gao, Xiaobing Li, Jianwei Chen, Weidong Gong, Kun Yue, Zhiqun Wu
BACKGROUND: To compare the efficiency and safety of uterine artery embolization (UAE) combined with local infusion of methotrexate (MTX) or MTX and 5-fluorouracil (5-FU) in the treatment of ectopic pregnancy (EP). METHODS: One hundred women with EP were prospectively enrolled from December 2012 to February 2015 and randomly allocated into 2 groups. One group was treated with UAE combined MTX, and the other with UAE combined with MTX and 5-FU. Local MTX was administrated at a dose of 80 to 120 mg, based on the initial β-human chorionic gonadotropin (β-HCG) levels, and 5-FU was given intra-arterially at a uniform dose of 0...
February 2018: Medicine (Baltimore)
L Haller, F Severac, C Rongieres, J Ohl, K Bettahar, I Lichtblau, O Pirrello
OBJECTIVE: Comparing rates of pregnancy and childbirth between IUI at either 24 or 48hours after injection of HCG. METHODS: This is a single-center retrospective study of couples who underwent intrauterine insemination between January 2013 and December 2014 at Medical-Surgical Obstetrical Centre of Schiltigheim. Stimulation of ovulation was done by FSH or HMG, and ovulation induction by 250μg of recombinant HCG. The insemination was performed after 2 days (group D2) or the day after (group D1)...
April 2017: Gynecologie, Obstetrique, Fertilite & Senologie
Sara Mahgoub, Victor Gabriele, Emilie Faller, Bruno Langer, Arnaud Wattiez, Lise Lecointre, Cherif Akladios
STUDY OBJECTIVE: To illustrate a laparoscopic technique for the resection of cesarean scar ectopic pregnancy, associated with isthmocele repair. DESIGN: Case report (Canadian Task Force classification III). SETTING: A tertiary referral center in Strasbourg, France. BACKGROUND: Cesarean scar pregnancy is a rare form of ectopic pregnancy. The major risk of this type of pregnancy is the early uterine rupture with massive, sometimes life-threatening, bleeding...
February 2018: Journal of Minimally Invasive Gynecology
Shu Zhang, Huan Yan, Wen-Ting Ji
OBJECTIVE: To investigate the efficacy and safety of uterine artery chemoembolization (UAE) combined with intra-arterial MTX infusion for the treatment of cervical pregnancy. METHODS: Retrospective chart review for 26 cervical pregnancy patients treated at Renji hospital between January 2000 and December 2012. 14 patients received UAE combined with intra-arterial MTX infusion (UAE group) and 12 patients received single intramuscular MTX injection combined with subsequent uterine curettage (non-UAE group)...
May 2016: Archives of Gynecology and Obstetrics
I E Timor-Tritsch, G Cali, A Monteagudo, N Khatib, R E Berg, F Forlani, E Avizova
OBJECTIVE: To demonstrate the efficacy of placement and inflation of Foley balloon catheters prophylactically to prevent, or as an adjuvant therapy to control, bleeding in women undergoing treatment for Cesarean scar pregnancy (CSP) or cervical pregnancy (CxP). METHODS: This was a retrospective study of 18 women with either CSP (n = 16) or CxP (n = 2), who underwent Foley balloon catheter placement under continuous transvaginal or transabdominal ultrasound guidance to prevent or manage bleeding following treatment, which in most cases comprised local (intragestational sac) and intramuscular (IM) methotrexate (MTX) injections...
July 2015: Ultrasound in Obstetrics & Gynecology
Haim Krissi, Liran Hiersch, Natan Stolovitch, Shmuel Nitke, Arnon Wiznitzer, Yoav Peled
OBJECTIVE: To determine the effectiveness and safety of uterine artery methotrexate (MTX) infusion and embolization combined with systemic MTX for treatment of non-tubal ectopic pregnancy. STUDY DESIGN: We retrospectively reviewed the electronic files of all women admitted to a single tertiary, university-affiliated medical center with a diagnosis of non-tubal (cervical, interstitial or cesarean section scar) ectopic pregnancy, who were treated by a combination of uterine artery MTX infusion and embolization and systemic MTX between January 2001 and March 2014...
November 2014: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Kalyansree Chaudhury, Sudeshna Chaudhury, Gautam Khastgir, Srikanta Purakaystha
Clomiphene citrate, by stimulating the endogenous gonadotrophin secretion, reduces the dose of exogenous gonadotrophin for controlled ovarian stimulation. However, the benefit of clomiphene citrate may be offset by its oestrogen-receptor depleting effect on target tissues like endometrium. Letrozole, an aromatase inhibitor, stimulates endogenous gonadotrophin secretion (like clomiphene citrate). However, it does not deplete oestrogen receptors and hence does not have adverse effect on endometrium (unlike clomiphene citrate)...
September 2013: Journal of the Indian Medical Association
M Kleppe, M H van Hooff, J P Rhemrev
In a descriptive retrospective cohort study, we determined the cumulative pregnancy rate for couples undergoing intra-uterine insemination (IUI) with at least one total motile sperm count (TMC) <1 million compared to couples with a TMC consistently >1 million. Eight hundred and ninety-five cycles in 273 couples were studied from 2006 to 2009. In 895 cycles, ovarian stimulation was performed through recFSH injections. IUI was scheduled 38 ± 2 h after the administration of HCG when at least one follicle measured >18 mm...
December 2014: Andrologia
Sujata Kar
OBJECTIVE: To compare Letrozole (5 mg) and clomiphene citrate (100 mg) as first line ovulation induction drug in infertile PCOS women. STUDY DESIGN: Prospective Randomised trial. SETTING: A Tertiary level infertility centre. PATIENTS: 103 infertile PCOS women. INTERVENTIONS: Treatment naïve infertile PCOS women were randomised to treatment with 5 mg letrozole (51 patients) or 100 mg clomiphene citrate (52 patients) daily starting day 2 to day 6 of menstrual cycle...
September 2012: Journal of Human Reproductive Sciences
Xia Wu, Xuebin Zhang, Jie Zhu, Wen Di
OBJECTIVES: The aim of this study was to investigate the efficacy and safety of uterine artery embolization (UAE) combined with intra-arterial methotrexate (MTX) infusion for the treatment of caesarean scar pregnancy (CSP), compared with systemic MTX injection combined with uterine curettage. STUDY DESIGN: A retrospective cohort study. An analysis of CSP patients was performed using records from the Department of Obstetrics and Gynecology in Renji Hospital for the period between January 1, 2000 and December 30, 2010...
March 2012: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Mark A Zakaria, Mazen E Abdallah, Valerie I Shavell, Jay M Berman, Michael P Diamond, David C Kmak
OBJECTIVE: To evaluate the use of uterine artery embolization (UAE) in conjunction with methotrexate in the conservative treatment of cervical ectopic pregnancy (CEP). DESIGN: Case series. SETTING: Tertiary-care university hospital. PATIENT(S): Cases of CEP treated at Hutzel Women's Hospital between January 1997 and December 2008. INTERVENTION(S): Multidose methotrexate treatment with or without UAE and intra-amniotic potassium chloride injection (KCl)...
March 1, 2011: Fertility and Sterility
Ulun Ulug, Suleyman Tosun, Esra Aksoy Jozwiak, Ali Mesut, Alper Sismanoglu, Mustafa Bahceci
BACKGROUND: The purpose of this study is to asses the frequency of subclinical pregnancy loss (SPL) among women undergoing controlled ovarian hyperstimulation (COH) and in-vitro fertilization with ICSI. METHODS: The study was retrospectively conducted in a private IVF center. SPL was defined by a temporary rise in serum beta hCG, along with the absence of signs of intra- and extra-uterine pregnancy by transvaginal ultrasonography. Overall 5273 COH and ICSI cycles with embryo transfer (ET) were segregated according to serum E(2) levels percentiles (-24th, 25th, 74th, and 75th), women age and the type of spermatozoa for assisted fertilization (ejaculated and surgically retrieved)...
June 2006: Journal of Assisted Reproduction and Genetics
F Zayed, I Ghazawi, L Francis, H Alchalabi
OBJECTIVE: This study was designed to evaluate the predictive value of beta-hCG levels in predicting the pregnancy outcome. METHODS: A retrospective analysis was done on 423 pregnant patients following assisted conception (stimulated in vitro fertilization [SIVF] and stimulated intra uterine insemination [SIUI]). These were monitored with plasma beta-hCG on day +18 post hCG injection. Ongoing pregnancy was defined as greater than 20 weeks. RESULTS: Four hundred twenty three patients had a positive serum quantitative beta-hCG level 18 days post hCG injection...
March 2001: Archives of Gynecology and Obstetrics
F T Kung, S Y Chang
OBJECTIVES: This retrospective study examined the overall efficacy of methotrexate chemotherapy in the treatment of cervical pregnancy and attempted to determine whether differences in the response to methotrexate therapy exist between patients with viable and nonviable cervical pregnancies. STUDY DESIGN: A MEDLINE database search and a bibliographic review of the relevant literature were conducted to find reported cases of cervical pregnancy treated with methotrexate administration during the period from 1983 to 1997...
December 1999: American Journal of Obstetrics and Gynecology
P Abboud, B Delépine, F Pigeon, L Bednarczyk, C Quéreux
OBJECTIVE: to evaluate the results of superovulation, protocol hMG-hCG, associated to IUI for treatment of infertility. PATIENTS AND METHODS: this prospective study, includes 77 couples who underwent 204 consecutive cycles of homologous IUI. The same protocol was applied for all the couples. hMG was administrated from cycle days 2 to 5 (3 then 2 ampuls per day). Patients were monitored daily, by evaluation of serum oestradiol. Insemination was done 36 to 38 hours after hCG injection...
June 1997: Contraception, Fertilité, Sexualité
J L Benifla, H Fernandez, E Sebban, E Darai, R Frydman, P Madelenat
OBJECTIVE: To evaluate medical treatment of interstitial pregnancy. METHODS: This series was a retrospective study of medical treatment of interstitial pregnancies which was managed in two French Departments of Obstetrics and Gynecology (Bichat public Hospital. Paris and A. Béclère public Hospital, Clamart, France). Fifteen patients with clear evidence of an unruptured interstitial pregnancy were treated by injection of methotrexate (MTX) or potassium chloride (KCL) without surgery since January 1988...
December 27, 1996: European Journal of Obstetrics, Gynecology, and Reproductive Biology
P diDonato, V F Nola, T V Pittman, V Marr, C Stubbs, D R Meldrum
OBJECTIVE: To determine whether leuprolide acetate (LA), given subcutaneously at the time of follicular maturity in stimulated cycles, can result in ovulation and in vivo fertilization. STUDY DESIGN: Sixty-seven women underwent 91 cycles of ovarian stimulation (OS) and received a single subcutaneous injection of 1 mg of LA when follicular maturity was reached. Only clomiphene citrate (CC) was used for 15 cycles, CC/FSH for 66 cycles and human menopausal gonadotropin only for 10 cycles...
October 1995: Journal of Reproductive Medicine
R Wainer, F Merlet, M Bailly, P Aegerter, S Tribalat, C Roussel, J P Bisson
The results of 109 intra-uterine inseminations with cryopreserved prepared donor semen (IUId) in stimulated cycles, performed among 42 couples from November 1987 to June 1991, were analysed. The single IUId was performed 39 +/- 3 hours after the injection of human chorionic gonadotrophin. For each IUID 1,25 +/- 1.4 x 10(6) motile spermatozoa (mean +/- standard deviation) were inseminated. 27 pregnancies were obtained and the pregnancy rate per cycle was 24.8%. The number of motile spermatozoa inseminated was significantly higher in the group of pregnant women than in the population without pregnancy (1...
November 1993: Contraception, Fertilité, Sexualité
J L Frederick, M S Denker, A Rojas, I Horta, S C Stone, R H Asch, J P Balmaceda
The objective of this study was to determine the conception rate in infertile couples in which the female partner was > or = 40 years old and who had received ovarian stimulation treatment and intra-uterine insemination (IUI). It was a retrospective study of 77 patients who underwent a total of 210 treatment cycles. Protocols for ovulation induction included clomiphene citrate, human menopausal gonadotrophin (HMG) and clomiphene citrate plus HMG. Patients were monitored using transvaginal ultrasound, and two IUI were performed 24 and 48 h after the determination of urinary luteinizing hormone (LH) surge or human chorionic gonadotrophin (HCG) injection...
December 1994: Human Reproduction
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