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https://www.readbyqxmd.com/read/28423690/preimplantation-factor-pif-protects-cultured-embryos-against-oxidative-stress-relevance-for-recurrent-pregnancy-loss-rpl-therapy
#1
Lindsay F Goodale, Soren Hayrabedran, Krassimira Todorova, Roumen Roussev, Sivakumar Ramu, Christopher Stamatkin, Carolyn B Coulam, Eytan R Barnea, Robert O Gilbert
Recurrent pregnancy loss (RPL) affects 2-3% of couples. Despite a detailed work-up, the etiology is frequently undefined, leading to non-targeted therapy. Viable embryos and placentae express PreImplantation Factor (PIF). Maternal circulating PIF regulates systemic immunity and reduces circulating natural killer cells cytotoxicity in RPL patients. PIF promotes singly cultured embryos' development while anti-PIF antibody abrogates it. RPL serum induced embryo toxicity is negated by PIF. We report that PIF rescues delayed embryo development caused by <3 kDa RPL serum fraction likely by reducing reactive oxygen species (ROS)...
March 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422084/an-algorithm-for-timely-transmission-of-solicitation-messages-in-rpl-for-energy-efficient-node-mobility
#2
Jihong Park, Ki-Hyung Kim, Kangseok Kim
The IPv6 Routing Protocol for Low Power and Lossy Networks (RPL) was proposed for various applications of IPv6 low power wireless networks. While RPL supports various routing metrics and is designed to be suitable for wireless sensor network environments, it does not consider the mobility of nodes. Therefore, there is a need for a method that is energy efficient and that provides stable and reliable data transmission by considering the mobility of nodes in RPL networks. This paper proposes an algorithm to support node mobility in RPL in an energy-efficient manner and describes its operating principle based on different scenarios...
April 19, 2017: Sensors
https://www.readbyqxmd.com/read/28410127/oxidative-stress-major-executioner-in-disease-pathology-role-in-sperm-dna-damage-and-preventive-strategies
#3
Shilpa Bisht, Rima Dada
Oxidative stress (OS) has been implicated in a wide array of diseases such as neurodegenerative disorders, autoimmune diseases, complex lifestyle diseases and cancer. OS is caused by an imbalance in production of Reactive Oxygen Species (ROS) and antioxidant defenses in the cell which results in the damage of cellular components, inactivate essential metabolic enzymes and disrupt signal transduction pathways. OS induces peroxidative damage to the sperm plasma membrane, DNA fragmentation in sperm nuclear/mitochondrial genome and causes dysregulation in levels of mRNAs/transcripts...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28346339/a-power-planning-algorithm-based-on-rpl-for-ami-wireless-sensor-networks
#4
Marcio L F Miguel, Edgard Jamhour, Marcelo E Pellenz, Manoel C Penna
The advanced metering infrastructure (AMI) is an architecture for two-way communication between electric, gas and water meters and city utilities. The AMI network is a wireless sensor network that provides communication for metering devices in the neighborhood area of the smart grid. Recently, the applicability of a routing protocol for low-power and lossy networks (RPL) has been considered in AMI networks. Some studies in the literature have pointed out problems with RPL, including sub-optimal path selection and instability...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28345611/copy-number-variation-profile-in-the-placental-and-parental-genomes-of-recurrent-pregnancy-loss-families
#5
Laura Kasak, Kristiina Rull, Siim Sõber, Maris Laan
We have previously shown an extensive load of somatic copy number variations (CNVs) in the human placental genome with the highest fraction detected in normal term pregnancies. Hereby, we hypothesized that insufficient promotion of CNVs may impair placental development and lead to recurrent pregnancy loss (RPL). RPL affects ~3% of couples aiming at childbirth and idiopathic RPL represents ~50% of cases. We analysed placental and parental CNV profiles of idiopathic RPL trios (mother-father-placenta) and duos (mother-placenta)...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28337825/expression-of-twist-in-the-first-trimester-trophoblast-and-decidual-tissue-of-women-with-recurrent-pregnancy-losses
#6
Jin Hee Ahn, Hye Ran Park, Chan-Woo Park, Dong-Wook Park, Joanne Kwak-Kim
PROBLEM: In this study, we aim to investigate if the expression of TWIST in the first-trimester placenta and decidua has any association with spontaneous abortion (SAB) and recurrent pregnancy losses (RPL). METHODS: Expression of TWIST was measured in the first-trimester trophoblast and decidual tissues using RT-PCR and immunohistochemistry. Women with a pregnancy loss comprised the study group (AB group) including women with two or more recurrent pregnancy loses (RPL group), and women with a spontaneous abortion who had no history of previous pregnancy losses (SAB group)...
March 24, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28326740/successful-pregnancy-after-intralipid-addition-to-sildenafil-and-enoxaparin-in-woman-with-history-of-recurrent-pregnancy-loss-rpl
#7
Malgorzata Jerzak, Monika Szafarowska, Monika Kniotek, Andrzej Gorski
OBJECTIVES: Does addition of Intralipid to sildenafil and enoxaparin immunotherapy improve pregnancy outcome? MATERIALS AND METHOD: Report of a striking case of a patient with history of 4 recurrent pregnancy losses (RPL) and IVF failures. RESULTS: Adding of Intralipid resulted in giving birth to a healthy male baby in the 3th IVF cycle. CONCLUSION: Combination therapy that includes Intralipid may generate successful IVF outcome, although this problem merits further study, especially regarding safety issues...
December 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28282525/association-between-vascular-endothelial-growth-factor-polymorphism-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#8
REVIEW
Yaling Sun, Min Chen, Benyu Mao, Xianglin Cheng, Xianping Zhang, Chuanxin Xu
PURPOSE: Some studies have reported that vascular endothelial growth factor (VEGF) genetic polymorphisms are associated with recurrent pregnancy loss (RPL), but the results are controversial. This study is aimed to quantify the strength of this association. METHODS: A systematic review of the published literature from Medline, Springer, and China National Knowledge Infra structure (CNKI) databases was conducted and investigations of VEGF genetic polymorphisms in RPL were selected...
March 2, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28262239/lmwh-in-ivf-biomarkers-and-benefits
#9
Simon Fishel, Deborah J Baker, Ian A Greer
There is biological plausibility that coagulation activation underlies a proportion of in vitro fertilisation IVF failures and recurrent early clinical pregnancy loss (RPL). However, low-molecular-weight heparin (LMWH) use, based upon previous clinical outcome alone, is not effective in preventing RPL. RPL is heterogeneous in mechanism. Identifying those with an underlying thrombotic mechanism would allow stratification for LMWH treatment. Annexin A5 is an anticoagulant protein expressed on the trophoblast surface...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28261247/selection-of-candidate-reference-genes-for-gene-expression-analysis-in-kentucky-bluegrass-poa-pratensis-l-under-abiotic-stress
#10
Kuiju Niu, Yi Shi, Huiling Ma
Kentucky bluegrass (Poa pratensis L.) belong to Gramineae and is widely used in lawns, golf courses, landscapes, and sport fields as a prominent cool-season grass. Gene expression patterns during different stages of plant development can provide clues toward the understanding of its biological functions. The selection and validation of reference genes are the first steps in any real-time quantitative PCR gene expression study. Therefore, suitable reference genes are necessary for obtaining reliable results in real-time quantitative PCR analyses of Kentucky bluegrass...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28214760/genotyping-analysis-of-protein-s-tokushima-k196e-and-the-involvement-of-protein-s-antigen-and-activity-in-patients-with-recurrent-pregnancy-loss
#11
Yasushi Matsukawa, Eriko Asano, Tomohide Tsuda, Hiroyuki Kuma, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Mayumi Sugiura-Ogasawara
OBJECTIVE: Preston et al. indicated that Protein S (PS) deficiency was associated with stillbirths but not miscarriages. The PS-Tokushima missense variant was reported to serve as a genetic risk factor for deep vein thrombosis in the Japanese population. A previous cross-sectional study showed no increase in the prevalence of PS-Tokushima in patients with recurrent early pregnancy loss or in patients with intra uterine fetal death and/or fetal growth restriction. There has been limited number of prospective studies examining the pregnancy outcome in patients with both a PS deficiency and recurrent pregnancy loss (RPL)...
February 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28176193/obstetric-outcomes-of-recurrent-pregnancy-loss-patients-diagnosed-w%C3%A4-th-inherited-thrombophilia
#12
C Karadağ, T Yoldemir, S D Karadağ, C İnan, Z N Dolgun, L Aslanova
BACKGROUND: Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies. The relation between RPL and inherited thrombophilia requires anticoagulant therapy during pregnancy. However the obstetric outcomes have not been well defined in these RPL patients diagnosed with inherited thrombophilia, who have been given anticoagulant therapy. AIM: To investigate the obstetric outcomes in pregnant women with RPL who are given low molecular weight heparin (LMWH) and low-dose aspirin due to diagnosis of inherited thrombophilia...
February 7, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28132421/serologic-markers-of-autoimmunity-in-women-with-recurrent-pregnancy-loss
#13
Katrin Hefler-Frischmuth, Katharina Walch, Lukas Hefler, Clemens Tempfer, Christoph Grimm
PROBLEM: Various autoimmunologic mechanisms have been shown to be involved in recurrent pregnancy loss (RPL). This study aimed to evaluate whether women with RPL have elevated serum levels of common autoimmunologic parameters. METHOD OF STUDY: Serum levels of antinuclear antibodies (ANAs) were measured in 114 women with RPL, and 107 healthy controls using a qualitative immunometric enzyme immunoassay, serum levels of IgG class autoantibodies against histone, IgG class autoantibodies against nucleosomes, and IgG class autoantibodies against double-stranded (ds) DNA were measured by quantitative enzyme immunoassays...
January 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28108842/genetic-analysis-of-the-m2-anxa5-haplotype-as-recurrent-pregnancy-loss-predisposition-in-the-malay-population
#14
Kai-Cheen Ang, Sushilnathan Kathirgamanathan, Ewe Seng Ch'ng, Yan-Yeow Lee, Anna-Liza Roslani, Bavanandan Naidu, Krishna Kumar, Ridzuan Abdullah, Siti-Nadiah Abdul Kadir, Narazah Mohd Yusoff, Wan Zaidah Abdullah, Nadja Bogdanova, Peter Wieacker, Arseni Markoff, Thean-Hock Tang
PURPOSE: The aim of this study was to evaluate a new predisposition factor, M2/ANXA5 (RPRGL3), in recurrent pregnancy loss (RPL) patients of Malay origin, since it was previously known that the prevalence of this condition is relatively high among the Malay population of Malaysia, where conventional hereditary thrombophilia factors have been generally ruled out. METHODS: A total of 232 women who had experienced ≥2 unexplained RPL and 141 available male partners were recruited, with 360 healthy Malay and 166 parous female controls...
January 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28103273/association-between-genetic-polymorphisms-in-interleukin-genes-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#15
Meixiang Zhang, Jiawei Xu, Xiao Bao, Wenbin Niu, Linlin Wang, Linqing Du, Nan Zhang, Yingpu Sun
Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0...
2017: PloS One
https://www.readbyqxmd.com/read/28048753/su-f-i-32-organ-doses-from-pediatric-head-ct-scan
#16
H Liu, Q Liu, J Qiu, M Majer, Z Knezevic, S Miljanic, H Hrsak, W Zhuo
PURPOSE: To evaluate the organ doses of pediatric patients who undergoing head CT scan using Monte Carlo (MC) simulation and compare it with measurements in anthropomorphic child phantom.. METHODS: A ten years old children voxel phantom was developed from CT images, the voxel size of the phantom was 2mm*2mm*2mm. Organ doses from head CT scan were simulated using MCNPX software, 180 detectors were placed in the voxel phantom to tally the doses of the represented tissues or organs...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047291/su-f-t-175-absorbed-dose-measurement-using-radiophotoluminescent-glass-dosimeter-in-therapeutic-proton-beam
#17
W Chang, Y Koba, T Katayose, M Hariu, K Yasui, H Saitoh
PURPOSE: To measure the absorbed dose to water Dw in therapeutic proton beam with radiophotoluminescent glass dosimeter (RGD), a methodology was proposed. In this methodology, the correction factor for the LET dependence of radiophotoluminescent (RPL) efficiency and the variation of mass stopping power ratio of water to RGD (SPRw, RGD) were adopted. The feasibility of proposed method was evaluated in this report. METHODS: The calibration coefficient in terms of Dw for RGDs (GD-302M, Asahi Techno Glass) was obtained using 60Co beam...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041830/luteal-phase-hcg-support-for-unexplained-recurrent-pregnancy-loss-a-low-hanging-fruit
#18
Chelsea Fox, Denise Azores-Gococo, Linda Swart, Kristin Holoch, Ricardo F Savaris, Creighton E Likes, Paul B Miller, David A Forstein, Bruce A Lessey
Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies and accounts for only 1-5% of pregnancy failures. Treatment options for unexplained RPL (uRPL) are limited. Previous studies suggest a link between delayed implantation and pregnancy loss. Based on this, a timely signal for rescue of the corpus luteum (CL) using human chorionic gonadotrophin (HCG) could improve outcomes in women with uRPL. This retrospective cohort study included 98 subjects with uRPL: 45 underwent 135 monitored cycles without HCG support; and 53 underwent 142 cycles with a single mid-luteal HCG injection...
December 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28012790/the-role-of-parental-microrna-alleles-in-recurrent-pregnancy-loss-an-association-study
#19
Mona Amin-Beidokhti, Reza Mirfakhraie, Shohreh Zare-Karizi, Fatemeh Karamoddin
The medical evaluation of recurrent pregnancy loss (RPL), the occurrence of two or more consecutive pregnancy losses prior to 20th week of gestation, is mainly focused on maternal factors. However, paternally expressed genes may also play a role in implantation and placenta quality. This study aimed to investigate the possible association between parental miR-196a2C>T and miR-499aT>C polymorphisms and RPL in a case-control study including 200 RPL couples and 400 healthy men and women. Genotyping was performed using Tetra-ARMS-PCR and PCR-RFLP for miR-196a2C>T and miR-499aT>C polymorphisms, respectively...
December 13, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27957683/heterogeneity-of-brain-ribosomal-genes-expression-following-positive-fighting-experience-in-male-mice-as-revealed-by-rna-seq
#20
Dmitry A Smagin, Irina L Kovalenko, Anna G Galyamina, Yuriy L Orlov, Vladimir N Babenko, Natalia N Kudryavtseva
Repeated positive fighting experience in daily agonistic interactions is accompanied by changes of brain neurotransmitter activity and genes' expression in male mice. This paper is focused on the analysis of ribosomal genes expression data as revealed by whole-transcriptome analysis (RNA-Seq) in five brain regions of male mice with long repeated experience of aggression accompanied by wins (winners). Downregulation of most Rps, Rpl, Mrps, and Mrpl genes was found in the midbrain raphe nuclei and striatum and upregulation-in the hippocampus and hypothalamus of the winners...
December 12, 2016: Molecular Neurobiology
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