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https://www.readbyqxmd.com/read/29435277/methylenetetrahydrofolate-reductase-gene-c677t-and-a1298c-polymorphisms-and-susceptibility-to-recurrent-pregnancy-loss
#1
Domenico Dell'Edera, Antonella L'Episcopia, Francesca Simone, Maria Giovanna Lupo, Annunziata Anna Epifania, Arianna Allegretti
Several studies have investigated the link between two different polymorphisms (C677T and A1298T) of the gene encoding methylenetetrahydrofolate reductase (MTHFR) and the risk of recurrent pregnancy loss (RPL); however, the results remain controversial. This study aimed to provide greater insight into this debated topic. In the current study, two groups of pregnant women (group A: RPL women; group B: non-RPL women), each of which were subdivided further into two subgroups based on their gestational age, were screened for C677T and A1298T variants of the MTHFR gene...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29433402/the-effect-of-low-dose-ovarian-stimulation-with-hmg-plus-progesterone-on-pregnancy-outcome-in-women-with-history-of-recurrent-pregnancy-loss-and-secondary-infertility-a-retrospective-cohort-study
#2
Maria Elisabetta Coccia, Francesca Rizzello, Mauro Cozzolino, Valentina Turillazzi, Tommaso Capezzuoli
We assessed the outcome of pregnancy in women with a history of recurrent pregnancy loss (RPL) following treatment with low-dose human menopausal gonadotropin (HMG)+progesterone or progesterone alone. This single-center retrospective cohort study included data from women diagnosed with RPL and treated between February 2005 and December 2012 with one cycle of HMG + progesterone or progesterone alone. Primary endpoint was the rate of ongoing pregnancies and losses by treatment, age (<38 vs. ≥38 years) and in the subgroup with unexplained RPL...
February 12, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29411465/association-mapping-reveals-candidate-loci-for-resistance-and-anemic-response-to-an-emerging-temperature-driven-parasitic-disease-in-a-wild-salmonid-fish
#3
F Ahmad, P V Debes, G Palomar, A Vasemägi
Even though parasitic infections are often costly or deadly for the host, we know very little which genes influence parasite susceptibility and disease severity. Proliferative kidney disease (PKD) is an emerging and, at elevated water temperatures, potentially deadly disease of salmonid fishes that is caused by the myxozoan parasite Tetracapsuloides bryosalmonae. By screening > 7.6 K SNPs in 255 wild brown trout (Salmo trutta) and combining association mapping and random forest approaches, we identified several candidate genes for both the parasite resistance (inverse of relative parasite load; RPL) and the severe anemic response to the parasite...
February 7, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29373499/a-proposal-for-iot-dynamic-routes-selection-based-on-contextual-information
#4
Harilton da Silva Araújo, Raimir Holanda Filho, Joel J P C Rodrigues, Ricardo de A L Rabelo, Natanael de C Sousa, José C C L S Filho, José V V Sobral
The Internet of Things (IoT) is based on interconnection of intelligent and addressable devices, allowing their autonomy and proactive behavior with Internet connectivity. Data dissemination in IoT usually depends on the application and requires context-aware routing protocols that must include auto-configuration features (which adapt the behavior of the network at runtime, based on context information). This paper proposes an approach for IoT route selection using fuzzy logic in order to attain the requirements of specific applications...
January 26, 2018: Sensors
https://www.readbyqxmd.com/read/29351691/out-of-field-doses-in-children-treated-for-large-arteriovenous-malformations-using-hypofractionated-gamma-knife-radiosurgery-and-intensity-modulated-radiation-therapy
#5
Marijke De Saint-Hubert, Marija Majer, Hrvoje Hršak, Zdravko Heinrich, Željka Kneževic, Saveta Miljanic, Paulina Porwol, Liliana Stolarczyk, Filip Vanhavere, Roger M Harrison
The purpose of this study was to measure out-of-field organ doses in two anthropomorphic child phantoms for the treatment of large brain arteriovenous malformations (AVMs) using hypofractionated gamma knife (GK) radiosurgery and to compare these with an alternative treatment using intensity-modulated radiation therapy (IMRT). Target volume was identical in size and shape in all cases. Radiophotoluminescent (RPL), thermoluminescent (TL) and optically stimulated luminescent (OSL) dosimeters were used for out-of-field dosimetry during GK treatment and a good agreement within 1-2% between results was shown...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29347522/semiclassical-catastrophe-theory-of-simple-bifurcations
#6
A G Magner, K Arita
The Fedoriuk-Maslov catastrophe theory of caustics and turning points is extended to solve the bifurcation problems by the improved stationary phase method (ISPM). The trace formulas for the radial power-law (RPL) potentials are presented by the ISPM based on the second- and third-order expansion of the classical action near the stationary point. A considerable enhancement of contributions of the two orbits (pair consisting of the parent and newborn orbits) at their bifurcation is shown. The ISPM trace formula is proposed for a simple bifurcation scenario of Hamiltonian systems with continuous symmetries, where the contributions of the bifurcating parent orbits vanish upon approaching the bifurcation point due to the reduction of the end-point manifold...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29313278/genetic-and-epigenetic-variations-associated-with-idiopathic-recurrent-pregnancy-loss
#7
REVIEW
Luis Alejandro Arias-Sosa, Iván Darío Acosta, Elkin Lucena-Quevedo, Harold Moreno-Ortiz, Clara Esteban-Pérez, Maribel Forero-Castro
Recurrent pregnancy loss (RPL) is a reproductive disorder defined as two or more successive and spontaneous pregnancy losses (before 20 weeks of gestation), which affects approximately 1-2% of couples. At present, the causes of RPL remain unknown in a considerable number of cases, leading to complications in treatment and high levels of stress in couples. Idiopathic recurrent pregnancy loss (iRPL) has become one of the more complicated reproductive problems worldwide due to the lack of information about its etiology, which limits the counseling and treatment of patients...
January 9, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29281611/association-of-of-il-1-receptor-antagonist-il-1rn-and-interleukin-1%C3%AE-genes-il-1%C3%AE-polymorphisms-with-recurrent-pregnancy-loss-in-iranian-azeri-women
#8
Seyyed Ali Rahmani, Zeynab Paknejad, Masoumeh Mohammadkhanlou, Marina Daneshparvar
Objective One of the most important problems in human reproduction is recurrent pregnancy loss (RPL). RPL is defined as three or more consecutive abortions in the first trimester of pregnancy. The association between the polymorphisms in the immunological factors and RPL was investigated. The aim of our study was to determine the association of interleukin receptor antagonist (IL-IRN) and interleukin-1β (IL-1β) polymorphisms with RPL in Iranian Azeri women. Materials and methods The study participants consisted of 100 women with RPL of Iranian Azeri origin...
December 27, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29276169/prevalence-and-treatment-choices-for-couples-with-recurrent-pregnancy-loss-due-to-structural-chromosomal-anomalies
#9
Savanie Maithripala, Ursula Durland, Jon Havelock, Sonya Kashyap, Jason Hitkari, Justin Tan, Mahmoud Iews, Sarka Lisonkova, Mohamed A Bedaiwy
OBJECTIVE: Parental carriers of balanced structural chromosomal rearrangements such as reciprocal or Robertsonian translocations are at increased risk of recurrent pregnancy loss (RPL) due to the production of gametes with unbalanced non-viable chromosome variants. As a purported means of improving reproductive outcomes in this population, IVF and preimplantation genetic diagnosis (PGD) have been introduced as an alternative to natural conception and prenatal diagnosis. In this study, we evaluate the prevalence and treatment choices of couples with structural chromosomal rearrangement referred to a tertiary care RPL clinic...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29243350/maternal-history-of-recurrent-pregnancy-loss-is-associated-with-increased-risk-for-long-term-pediatric-gastrointestinal-morbidity-in-the-offspring
#10
Yael Lichtman, Eyal Sheiner, Tamar Wainstock, Idit Segal, Daniella Landau, Asnat Walfisch
PROBLEM: Recurrent pregnancy loss (RPL) potentially involves an abnormal maternal inflammatory response. We investigated whether children of mothers with a history of RPL are at an increased risk for childhood gastrointestinal (GI) morbidity, with a specific focus on inflammatory bowel diseases (IBD). METHOD OF STUDY: A population-based cohort analysis comparing the risk for long-term GI morbidity in children born to mothers with and without a history of RPL. Gastrointestinal (GI) morbidity included hospitalizations involving a pre-defined set of ICD-9 codes...
December 15, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29224883/utilization-of-protein-in-red-clover-and-alfalfa-silages-by-lactating-dairy-cows-and-growing-lambs
#11
Glen A Broderick
Feeding trials were conducted with lactating cows and growing lambs to quantify effects of replacing dietary alfalfa silage (AS) with red clover silage (RCS) on nutrient utilization. The lactation trial had a 2 × 4 arrangement of treatments: AS or RCS fed with no supplement, rumen-protected Met (RPM), rumen-protected Lys (RPL), or RPM plus RPL. Grass silage was fed at 13% of dry matter (DM) with AS to equalize dietary neutral detergent fiber (NDF) and crude protein contents. All diets contained (DM basis) 5% corn silage and 16% crude protein...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29218261/bilateral-occipital-lobe-hemorrhages-presenting-as-denial-of-blindness-in-posterior-reversible-encephalopathy-syndrome-a-rare-combination-of-anton-syndrome-and-encephalopathy
#12
Raja Godasi, Chintan Rupareliya, Pradeep C Bollu
Posterior reversible encephalopathy syndrome (PRES) or reversible posterior leukoencephalopathy (RPL) is an acute neurological syndrome characterized by the development of radiological abnormalities on brain imaging along with clinical manifestations, such as a headache, seizures, encephalopathy, etc. We report the case of a middle-aged male who presented to the emergency department after he woke up with complete blindness and was found to have hemorrhagic PRES. Intracranial hemorrhages were seen in around 15% of patients who presented with this condition...
October 4, 2017: Curēus
https://www.readbyqxmd.com/read/29195508/thbd-sequence-variants-potentially-related-to-recurrent-pregnancy-loss
#13
Paula Quintero-Ronderos, Eric Mercier, Jean-Christophe Gris, Clara Esteban-Perez, Harold Moreno-Ortiz, Dora Janeth Fonseca, Elkin Lucena, Daniel Vaiman, Paul Laissue
Recurrent pregnancy loss (RPL) is a frequently occurring disease, which is classified as idiopathic in more than 50% of cases. THBD, the endothelial cell receptor for thrombin, has been associated with distinct biological processes and considered a coherent RPL-related candidate gene. In the present study, we have sequenced the complete coding region of THBD in 262 patients affected by RPL. Bioinformatics analysis and screening of controls strongly suggested that the THBD-p.Trp153Gly mutation might be related to RPL aetiology...
December 1, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29193686/genetic-linkage-studies-for-the-non-geneticist
#14
S Romero
No abstract text is available yet for this article.
November 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29187946/the-endoscopic-endonasal-approach-to-cranio-cervical-junction-the-complete-panel
#15
REVIEW
Nouman Aldahak, Bertram Richter, Joseph Synèse Bemora, Jeffery Thomas Keller, Sebastien Froelich, Khaled Mohamed Abdel Aziz
We aim to establish a complete summary on the Endoscopic Endonasal Approach (EEA) to Cranio Cervical Junction (CCJ): evolution since first description, criteria to predict the feasibility and limitations, anatomical landmarks, indications and biomechanical evaluation after performing the approach. A comprehensive literature search to identify all available literature published between March 2002 and June 2015, the articles were divided into four categories according to their main purpose: 1- surgical technique, 2- anatomical landmarks and limitations, 3- literature reviews to identify main indications, 4- biomechanical studies...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29184886/expression-profiling-of-ribosomal-protein-gene-family-in-dehydration-stress-responses-and-characterization-of-transgenic-rice-plants-overexpressing-rpl23a-for-water-use-efficiency-and-tolerance-to-drought-and-salt-stresses
#16
Mazahar Moin, Achala Bakshi, M S Madhav, P B Kirti
Our previous findings on the screening of a large-pool of activation tagged rice plants grown under limited water conditions revealed the activation of Ribosomal Protein Large (RPL) subunit genes, RPL6 and RPL23A in two mutants that exhibited high water-use efficiency (WUE) with the genes getting activated by the integrated 4x enhancers (Moin et al., 2016a). In continuation of these findings, we have comprehensively characterized the Ribosomal Protein (RP) gene family including both small (RPS) and large (RPL) subunits, which have been identified to be encoded by at least 70 representative genes; RP-genes exist as multiple expressed copies with high nucleotide and amino acid sequence similarity...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29174418/responses-of-human-ankle-muscles-to-mediolateral-balance-perturbations-during-walking
#17
A L Hof, J Duysens
During walking our balance is maintained by muscle action. In part these muscle actions automatically respond to the imbalance. This paper considers responses to balance perturbations in muscles around the ankle, peroneus longus (PL), tibialis anterior (TA) and soleus (SO). It is investigated if their action is related to previously observed balance mechanisms: the 'braking reaction' and the mediolateral ankle strategy. Subjects walked on a treadmill and received pushes to the left and pulls to the right in various phases of the gait cycle...
November 22, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29165619/comparison-of-response-of-passive-dosimetry-systems-in-scanning-proton-radiotherapy-a-study-using-paediatric-anthropomorphic-phantoms
#18
Ž Kneževic, I Ambrozova, C Domingo, M De Saint-Hubert, M Majer, I Martínez-Rovira, S Miljanic, N Mojzeszek, P Porwol, O Ploc, M Romero-Expósito, L Stolarczyk, S Trinkl, R M Harrison, P Olko
Proton beam therapy has advantages in comparison to conventional photon radiotherapy due to the physical properties of proton beams (e.g. sharp distal fall off, adjustable range and modulation). In proton therapy, there is the possibility of sparing healthy tissue close to the target volume. This is especially important when tumours are located next to critical organs and while treating cancer in paediatric patients. On the other hand, the interactions of protons with matter result in the production of secondary radiation, mostly neutrons and gamma radiation, which deposit their energy at a distance from the target...
November 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29154465/the-role-of-immunological-testing-and-intervention-in-reproductive-medicine-a-fertile-collaboration
#19
REVIEW
Syed B Ali, Yogesh Jeelall, Craig E Pennell, Roger Hart, Andrew McLean-Tooke, Michaela Lucas
Advances in reproductive medicine have significantly increased the success of fertility treatments. Nevertheless, some women experience recurrent implantation failure (RIF) after in-vitro fertilization (IVF) or recurrent pregnancy loss (RPL). Imbalances in the immune system and failure to achieve immune tolerance to the foetus have been implicated as potentially modifiable causes of idiopathic RIF and RPL. As such, women are increasingly being treated with immunomodulatory agents in an attempt to achieve a successful pregnancy...
November 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29136194/fast-skin-dose-estimation-system-for-interventional-radiology
#20
Takeshi Takata, Jun'ichi Kotoku, Hideyuki Maejima, Shinobu Kumagai, Norikazu Arai, Takenori Kobayashi, Kenshiro Shiraishi, Masayoshi Yamamoto, Hiroshi Kondo, Shigeru Furui
To minimise the radiation dermatitis related to interventional radiology (IR), rapid and accurate dose estimation has been sought for all procedures. We propose a technique for estimating the patient skin dose rapidly and accurately using Monte Carlo (MC) simulation with a graphical processing unit (GPU, GTX 1080; Nvidia Corp.). The skin dose distribution is simulated based on an individual patient's computed tomography (CT) dataset for fluoroscopic conditions after the CT dataset has been segmented into air, water and bone based on pixel values...
November 10, 2017: Journal of Radiation Research
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