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https://www.readbyqxmd.com/read/28641397/myocardial-scar-location-as-detected-by-cardiac-magnetic-resonance-is-associated-with-the-outcome-in-heart-failure-patients-undergoing-surgical-ventricular-reconstruction
#1
Serenella Castelvecchio, Giulia Careri, Federico Ambrogi, Antonia Camporeale, Lorenzo Menicanti, Francesco Secchi, Massimo Lombardi
OBJECTIVES: Post-infarction myocardial scar causes adverse left ventricular remodelling and negatively affects the prognosis. We sought to investigate whether scar extent and location obtained by cardiac magnetic resonance may affect the reverse remodelling and survival of heart failure patients undergoing surgical ventricular reconstruction. METHODS: From January 2011 to December 2015, 151 consecutive patients with previous myocardial infarction and left ventricular remodelling underwent surgical ventricular reconstruction at our Institution, of which 88 (58%) patients had a preoperative protocol-standardized late gadolinium enhancement (LGE)-cardiac magnetic resonance examination during the week before surgery...
June 21, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28641394/reoperative-analysis-after-mitral-valve-repair-with-glutaraldehyde-treated-autologous-pericardium
#2
Naoto Fukunaga, Ryuzo Sakata, Tadaaki Koyama
OBJECTIVES: We reviewed reoperations following mitral valve repair (MVR) that used glutaraldehyde-treated autologous pericardium for mitral regurgitation (MR) to analyse the durability and risk factors for reoperation. METHODS: We retrospectively analysed 144 patients (mean age 57.9 years) who underwent MVR using glutaraldehyde-treated pericardium from March 1992 to December 2011. A total of 19 reoperations were necessary during the follow-up period (mean 6.9 years)...
June 21, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28641368/glomerular-hyperfiltration-in-obese-african-american-hypertensive-patients-is-associated-with-elevated-urinary-mitochondrial-dna-copy-number
#3
Alfonso Eirin, Ahmed Saad, John R Woollard, Luis A Juncos, David A Calhoun, Hui Tang, Amir Lerman, Stephen C Textor, Lilach O Lerman
BACKGROUND: Glomerular hyperfiltration may contribute to the high incidence of renal disease in Obese African Americans essential hypertensive (ObAAEH) patients, but the precise mechanisms responsible for renal injury have not been elucidated. Mitochondria are important determinants of renal injury in hypertension, and increased levels of mitochondrial DNA (mtDNA) in the urine may indicate renal mitochondrial injury. We hypothesized that urine mtDNA copy numbers would be higher in ObAAEH compared to Caucasian essential hypertensive (CEH) patients...
June 14, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28641310/potentiating-the-effects-of-radiotherapy-in-rectal-cancer-the-role-of-aspirin-statins-and-metformin-as-adjuncts-to-therapy
#4
K J Gash, A C Chambers, D E Cotton, A C Williams, M G Thomas
BACKGROUND: Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20-30% of patients. Drug repurposing for anti-cancer treatments is gaining momentum, but the potential of such drugs as adjuncts, to increase tumour response to chemo-radiotherapy in rectal cancer, is only just beginning to be recognised. METHODS: A systematic literature search was conducted and all studies investigating the use of drugs to enhance response to neo-adjuvant radiation in rectal cancer were included...
June 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28641294/the-impact-of-gender-on-tumour-stage-in-in-house-complications-and-choice-of-urinary-diversion-results-of-the-austrian-cystectomy-registry
#5
Tanja Gschliesser, Klaus Eredics, Ingrid Berger, Michael Szelinger, Hans Christoph Klingler, Thomas Colombo, Anton Ponholzer, Eugen Plas, Karl Grubmüller, Michael Dunzinger, Klaus Jeschke, Erich Würnschimmel, Frens Steffen Krause, Sharokh Shariat, Karl Leeb, Alexandre Pelzer, Claus Riedl, Michael Rauchenwald, Wilhelm Hübner, Clemens Brössner, Stephan Madersbacher
INTRODUCTION AND OBJECTIVES: Bladder cancer is characterized by gender-dependent disparities. To further address this issue, we analysed a prospective, multicentre cystectomy registry. METHODS: An online database was developed that included patient demographics, intra/perioperative data, surgical data and in-house complications. RESULTS: Four hundred fifty-eight patients (112 [24.5%] women and 346 [75.5%] men) were analysed. Men and women were comparable regarding age (mean 68 years), body mass index (mean 26...
June 23, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28641258/quality-assessment-of-perceptual-crosstalk-on-two-view-auto-stereoscopic-displays
#6
Jongyoo Kim, Taewan Kim, Sanghoon Lee, Alan C Bovik
Crosstalk is one of the most severe factors affecting the perceived quality of stereoscopic 3D (S3D) images. It arises from a leakage of light intensity between multiple views, as in auto-stereoscopic displays. Well-known determinants of crosstalk include the co-location contrast and disparity of the left and right images, which have been dealt with in prior studies. However, when a natural stereo image that contains complex naturalistic spatial characteristics is viewed on an auto-stereoscopic display, other factors may also play an important role in the perception of crosstalk...
June 19, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28641154/serum-albumin-adjusted-glycated-albumin-as-a-better-indicator-of-glycemic-control-in-type-2-diabetes-mellitus-patients-with-short-duration-of-hemodialysis
#7
Takahiro Yajima, Kumiko Yajima, Makoto Hayashi, Hiroshi Takahashi, Keigo Yasuda
AIMS: Serum albumin-adjusted glycated albumin (adjusted GA) is reportedly a better predictor of mortality than GA in patients with Type 2 diabetes mellitus (T2DM) on hemodialysis (HD). We compared how accurately GA and adjusted GA reflected glycemic control in these patients. METHODS: We enrolled 31 patients with T2DM on HD. They were divided into two groups according to duration of HD: ≤6months (short HD group, N=16) and >6months (long HD group, N=15). GA or adjusted GA and parameters of glycemic control obtained by continuous glucose monitoring were measured, and the correlations between these were analyzed...
June 9, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28641146/early-development-and-predictors-of-morphological-awareness-disentangling-the-impact-of-decoding-skills-and-phonological-awareness
#8
Jeremy M Law, Pol Ghesquière
BACKGROUND: Morphological Awareness (MA) has been demonstrated to be influential on the reading outcomes of children and adults. Yet, little is known regarding MA's early development. AIM: The aim of this study is to better understand MA at different stages of development and its association with Phonological Awareness (PA) and reading. METHODS AND PROCEDURES: In a longitudinal design the development of MA was explored in a group of pre-reading children with a family risk of dyslexia and age-matched controls from kindergarten up to and including grade 2...
June 19, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28641119/maternal-progesterone-levels-are-modulated-by-maternal-bmi-and-predict-birth-weight-sex-specifically-in-human-pregnancies
#9
Anke Diemert, Janina Goletzke, Claus Barkmann, Robert Jung, Kurt Hecher, Petra Arck
OBJECTIVE: Successful pregnancy outcome is the result of a tailored adaptation of the maternal endocrine and immune system throughout gestation. We aimed to investigate if maternal endocrine, anthropometric and life style factors assessed longitudinally throughout pregnancy allow prediction of birth weight. STUDY DESIGN: Data on maternal factors and obstetrical characteristics from 220 pregnancies from a German prospective pregnancy cohort were analyzed using univariate and multivariate regression models...
June 3, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28641047/the-interaction-of-distress-tolerance-and-intolerance-of-uncertainty-in-the-prediction-of-symptom-reduction-across-cbt-for-social-anxiety-disorder
#10
Danielle Katz, Neil A Rector, Judith M Laposa
Distress tolerance (DT) and intolerance of uncertainty (IU) have been identified as transdiagnostic processes that predict symptom severity across a range of distinct anxiety disorders. However, the joint effect of these two variables on therapeutic outcome has not yet been examined. It is possible that DT and IU may both impact on treatment response to cognitive-behavioural therapy (CBT) in clients with anxiety, as clients with weak DT and strong IU may be less likely to engage in exposure and cognitive restructuring tasks across treatment due to their associated distress...
June 22, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28641029/gender-differences-in-the-trajectory-classes-of-depressive-symptoms-in-korean-older-adults
#11
Hyunjoo Lee, Sojung Park
OBJECTIVES: This study aimed (1) to identify gender-specific heterogeneous longitudinal patterns of depressive symptoms, (2) to explore the effects of economic status and various health conditions as risk factors in depressive symptom trajectories. METHOD: Data came from the Korean Longitudinal Study of Aging (2006-2012) focuing on older adults aged 65 and older. Latent class growth analysis was used to identify the depressive symptom trajectory groups. Multinomial logistic regression was used to examine the association between economic and health status changes and the depresison trajectories...
June 22, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28640987/independent-effects-of-apolipoprotein-e-and-cerebrovascular-burden-on-later-life-depression-the-wisconsin-longitudinal-study
#12
Rosanna G Scott, Daniel L Paulson
OBJECTIVE: Studies evaluating the effect of apolipoprotein E (APOE) on vascular depression are sparse, employ heterogeneous methods, and yield inconsistent results. One possibility is that APOE is a moderator of another predictor such as cerebrovascular burden. This longitudinal study examines the relationships between APOE, cerebrovascular burden, and depressive symptomatology in a large cohort sample from midlife to later life. METHODS: Data include 3,203 participants across 18 years (1993-2011) from the Wisconsin Longitudinal Study (baseline mean age = 53 years)...
June 20, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28640965/atypical-depression-and-double-depression-predict-new-onset-cardiovascular-disease-in-u-s-adults
#13
Stephanie M Case, Manisha Sawhney, Jesse C Stewart
BACKGROUND: Although depression is a risk factor for cardiovascular disease (CVD), it is unknown whether this risk varies across depressive disorder subtypes. Thus, we investigated atypical major depressive disorder (MDD) and double depression as predictors of new-onset CVD in a nationally representative sample of U.S. adults. METHODS: Prospective data from 28,726 adults initially free of CVD who participated in Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined...
June 22, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28640900/predictors-of-exclusive-breastfeeding-and-consumption-of-soft-semi-solid-or-solid-food-among-infants-in-boucle-du-mouhoun-burkina-faso-a-cross-sectional-survey
#14
Jenny A Cresswell, Rasmané Ganaba, Sophie Sarrassat, Simon Cousens, Henri Somé, Abdoulaye Hama Diallo, Veronique Filippi
INTRODUCTION: Exclusive breastfeeding is among the most effective interventions for preventing child mortality. The objectives of this paper are to describe infant feeding knowledge and practices in Boucle du Mouhoun, Burkina Faso; to identify predictors of exclusive breastfeeding among infants <6 months, and consumption of soft, semi-solid or solid food among infants 6-11 months; to describe mothers' sources of information regarding breastfeeding. METHODS: A cross-sectional survey (n = 2288) of a representative sample of women aged 15-49 years with at least one live birth in past year took place during June and July 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28640871/nomogram-to-predict-rectal-toxicity-following-prostate-cancer-radiotherapy
#15
Jean-Bernard Delobel, Khemara Gnep, Juan David Ospina, Véronique Beckendorf, Ciprian Chira, Jian Zhu, Alberto Bossi, Taha Messai, Oscar Acosta, Joël Castelli, Renaud de Crevoisier
BACKGROUND: To identify predictors of acute and late rectal toxicity following prostate cancer radiotherapy (RT), while integrating the potential impact of RT technique, dose escalation, and moderate hypofractionation, thus enabling us to generate a nomogram for individual prediction. METHODS: In total, 972 patients underwent RT for localized prostate cancer, to a total dose of 70 Gy or 80 Gy, using two different fractionations (2 Gy or 2.5 Gy/day), by means of several RT techniques (3D conformal RT [3DCRT], intensity-modulated RT [IMRT], or image-guided RT [IGRT])...
2017: PloS One
https://www.readbyqxmd.com/read/28640854/maternal-bmi-and-diabetes-in-pregnancy-investigating-variations-between-ethnic-groups-using-routine-maternity-data-from-london-uk
#16
Erin Nishikawa, Laura Oakley, Paul T Seed, Pat Doyle, Eugene Oteng-Ntim
OBJECTIVE: To investigate the ethnicity-specific association between body mass index (BMI) and diabetes in pregnancy, with a focus on the appropriateness of using BMI cut-offs to identify pregnant women at risk of diabetes. STUDY DESIGN: Analysis of routinely-collected data from a maternity unit in London, UK. Data were available on 53 264 women delivering between 2004 and 2012. Logistic regression was used to explore the association between diabetes in pregnancy and BMI among women of different ethnicities, and adjusted probability estimates were used to derive risk equivalent cut-offs...
2017: PloS One
https://www.readbyqxmd.com/read/28640805/high-confidence-assessment-of-functional-impact-of-human-mitochondrial-non-synonymous-genome-variations-by-apogee
#17
Stefano Castellana, Caterina Fusilli, Gianluigi Mazzoccoli, Tommaso Biagini, Daniele Capocefalo, Massimo Carella, Angelo Luigi Vescovi, Tommaso Mazza
24,189 are all the possible non-synonymous amino acid changes potentially affecting the human mitochondrial DNA. Only a tiny subset was functionally evaluated with certainty so far, while the pathogenicity of the vast majority was only assessed in-silico by software predictors. Since these tools proved to be rather incongruent, we have designed and implemented APOGEE, a machine-learning algorithm that outperforms all existing prediction methods in estimating the harmfulness of mitochondrial non-synonymous genome variations...
June 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28640778/a-cohort-study-of-blunt-cerebrovascular-injury-screening-in-children-are-they-just-little-adults
#18
Mackenzie R Cook, Cordelie E Witt, Robert H Bonow, Eileen M Bulger, Ken F Linnau, Saman Arbabi, Bryce R H Robinson, Joseph Cuschieri
BACKGROUND: Blunt cerebrovascular injuries (BCVI) are rare with nonspecific predictors, making optimal screening critical. Radiation concerns magnify these issues in children. The Eastern Association for the Surgery of Trauma (EAST) criteria, the Utah score (US) and the Denver criteria (DC) have been advocated for pediatric BCVI screening, though direct comparison is lacking. We hypothesized that current screening guidelines inaccurately identify pediatric BCVI. METHODS: This was a retrospective cohort study of pediatric trauma patients treated from 2005-2015 with radiographically confirmed BCVI...
June 20, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28640672/consistency-in-patient-reported-outcomes-after-total-hip-replacement
#19
Albin Bengtsson, Gabrielle S Donahue, Szilard Nemes, Göran Garellick, Ola Rolfson
Purpose - The primary objective in this study was to describe the patient-reported outcome measures (PROMs) of total hip replacement (THR) patients 6 years after index surgery. Second, we sought to analyze how the preoperative, 1- and 6-year outcomes were associated. Patients and methods - By assessing the Swedish Hip Arthroplasty Register (SHAR), 15,755 patients with complete follow-up were included in the study group. 1-year and 6-year response rates were 93% and 87%. PROMs used by the SHAR include the EQ-5D instrument, and 2 modified visual analogue scales, 1 for pain and 1 for satisfaction...
June 22, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28640659/phlda1-pleckstrin-homology-like-domain-family-a-member-1-knockdown-promotes-migration-and-invasion-of-mcf10a-breast-epithelial-cells
#20
Naieli Bonatto, Maria José Carlini, Simone Aparecida de Bessa Garcia, Maria Aparecida Nagai
PHLDA1 (pleckstrin homology-like domain, family A, member 1) is a multifunctional protein that plays distinct roles in several biological processes including cell death and therefore its altered expression has been identified in different types of cancer. Progressively loss of PHLDA1 was found in primary and metastatic melanoma while its overexpression was reported in intestinal and pancreatic tumors. Previous work from our group showed that negative expression of PHLDA1 protein was a strong predictor of poor prognosis for breast cancer disease...
June 22, 2017: Cell Adhesion & Migration
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