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https://www.readbyqxmd.com/read/28222540/top-altmetric-scores-in-the-parkinson-s-disease-literature
#1
Rui Araújo, Aaron A Sorensen, Stacy Konkiel, Bastiaan R Bloem
A new class of social web-based metrics for scholarly publications (altmetrics) has surfaced as a complement to traditional citation-based metrics. Our aim was to study and characterize those recent papers in the field of Parkinson's disease which had received the highest Altmetric Attention Scores and to compare this attention measure to the traditional metrics. The top 20 papers in our analysis covered a variety of topics, mainly new disease mechanisms, treatment options and risk factors for the development of PD...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28222402/impact-of-anchor-type-on-porcine-lumbar-biomechanics-finite-element-modelling-and-in-vitro-validation
#2
Martin Brummund, Vladimir Brailovski, Yvan Petit, Yann Facchinello, Jean-Marc Mac-Thiong
BACKGROUND: Rigid posterior implants used for spinal stabilization can be anchored to the vertebrae using pedicle screws or screws combined with transverse process hooks. In the present study, a finite element model of a porcine lumbar spine instrumented with screws and hooks is presented and validated. METHODS: The porcine lumbar spine model was validated using in-vitro measurements on six porcine specimens. Validation metrics included intervertebral rotations (L1 to L6) and nucleus pressure in the topmost cranial instrumented disc...
February 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28222363/very-short-term-reactive-forecasting-of-the-solar-ultraviolet-index-using-an-extreme-learning-machine-integrated-with-the-solar-zenith-angle
#3
Ravinesh C Deo, Nathan Downs, Alfio V Parisi, Jan F Adamowski, John M Quilty
Exposure to erythemally-effective solar ultraviolet radiation (UVR) that contributes to malignant keratinocyte cancers and associated health-risk is best mitigated through innovative decision-support systems, with global solar UV index (UVI) forecast necessary to inform real-time sun-protection behaviour recommendations. It follows that the UVI forecasting models are useful tools for such decision-making. In this study, a model for computationally-efficient data-driven forecasting of diffuse and global very short-term reactive (VSTR) (10-min lead-time) UVI, enhanced by drawing on the solar zenith angle (θs) data, was developed using an extreme learning machine (ELM) algorithm...
February 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28221991/detecting-clinically-meaningful-shape-clusters-in-medical-image-data-metrics-analysis-for-hierarchical-clustering-applied-to-healthy-and-pathological-aortic-arches
#4
Jan L Bruse, Maria A Zuluaga, Abbas Khushnood, Kristin McLeod, Hopewell N Ntsinjana, Tain-Yen Hsia, Maxime Sermesant, Xavier Pennec, Andrew M Taylor, Silvia Schievano
OBJECTIVE: Today's growing medical image databases call for novel processing tools to structure the bulk of data and extract clinically relevant information. Unsupervised hierarchical clustering may reveal clusters within anatomical shape data of patient populations as required for modern Precision Medicine strategies. Few studies have applied hierarchical clustering techniques to three-dimensional patient shape data and results depend heavily on the chosen clustering distance metrics and linkage functions...
February 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28221055/psychometric-properties-of-the-generalized-anxiety-disorder-questionnaire-iv-gad-q-iv-in-postpartum-mothers
#5
Mark E Pierson, Jason M Prenoveau, Michelle G Craske, Elena Netsi, Alan Stein
Generalized anxiety disorder (GAD) is a mental disorder of which the main feature is persistent and impairing worry. GAD symptoms are common for women during the postpartum period and GAD prevalence rates have been reported as higher in postpartum mothers than in the general population. Currently, little psychometric evidence exists for a screening measure to detect the possible presence of diagnosable GAD for postpartum women. The purpose of this investigation was to gather psychometric information for the Generalized Anxiety Disorder Questionnaire-IV (GAD-Q-IV; Newman et al...
February 20, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28220868/image-based-adaptive-optics-for-in-vivo-imaging-in-the-hippocampus
#6
D Champelovier, J Teixeira, J-M Conan, N Balla, L M Mugnier, T Tressard, S Reichinnek, S Meimon, R Cossart, H Rigneault, S Monneret, A Malvache
Adaptive optics is a promising technique for the improvement of microscopy in tissues. A large palette of indirect and direct wavefront sensing methods has been proposed for in vivo imaging in experimental animal models. Application of most of these methods to complex samples suffers from either intrinsic and/or practical difficulties. Here we show a theoretically optimized wavefront correction method for inhomogeneously labeled biological samples. We demonstrate its performance at a depth of 200 μm in brain tissue within a sparsely labeled region such as the pyramidal cell layer of the hippocampus, with cells expressing GCamP6...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220844/waist-to-height-ratio-is-an-effective-indicator-for-comprehensive-cardiovascular-health
#7
Shiwei Shen, Yun Lu, Huajin Qi, Feng Li, Zhenhai Shen, Liuxin Wu, Chengjian Yang, Ling Wang, Kedong Shui, Weifeng Yao, Dongchang Qiang, Jingting Yun, Lin Zhou
The aim of this study was to determine the associations between cardiovascular health and the waist circumference (WC) and waist-to-height ratio (WHtR). A cross-sectional study was performed recruiting 26701 middle-aged Chinese men. Of the seven ideal cardiovascular health metrics, body mass index (BMI), total cholesterol (TC), blood pressure (BP), and fasting blood glucose (FBG) were found to increase with an elevation of the mean WC and WHtR. The mean WC and WHtR were significantly lower in the subjects with intermediate or ideal cardiovascular health than those with poor or intermediate health...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220450/the-potential-role-of-symptom-questionnaires-in-palliative-and-supportive-cancer-care-delivery
#8
REVIEW
Angela M Stover, Ethan M Basch
PURPOSE OF REVIEW: The American Society of Clinical Oncology (ASCO) palliative care recommendations have been updated into a full guideline. Symptom questionnaires-completed and reviewed with patients during care delivery-are poised to play a large role in this guideline because they provide a more comprehensive understanding of symptoms. This article provides an overview of the guideline and describes how symptom questionnaires can be used to satisfy the guideline. RECENT FINDINGS: Standardized symptom questionnaires can be used for three purposes in care delivery: symptom management, referral to specialty palliative and supportive care, and to assess high-quality care...
February 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28218889/scaling-human-cancer-risks-from-low-let-to-high-let-when-dose-effect-relationships-are-complex
#9
Igor Shuryak, Albert J Fornace, Kamal Datta, Shubhankar Suman, Santosh Kumar, Rainer K Sachs, David J Brenner
Health risks from space radiations, particularly from densely ionizing radiations, represent an important challenge for long-ranged manned space missions. Reliable methods are needed for scaling low-LET to high-LET radiation risks for humans, based on animal or in vitro studies comparing these radiations. The current standard metric, relative biological effectiveness (RBE) compares iso-effect doses of two radiations. By contrast, a proposed new metric, radiation effects ratio (RER), compares effects of two radiations at the same dose...
February 20, 2017: Radiation Research
https://www.readbyqxmd.com/read/28218687/uv-radiation-from-physics-to-impacts
#10
EDITORIAL
Hanns Moshammer, Stana Simic, Daniela Haluza
Ultraviolet (UV) radiation has affected life at least since the first life forms moved out of the seas and crawled onto the land. Therefore, one might assume that evolution has adapted to natural UV radiation. However, evolution is mostly concerned with the propagation of the genetic code, not with a long, happy, and fulfilling life. Because rickets is bad for a woman giving birth, the beneficial effects of UV-radiation outweigh the adverse effects like aged skin and skin tumors of various grades of malignancy that usually only afflict us at older age...
February 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28218399/smooth-operator-the-effects-of-different-3d-mesh-retriangulation-protocols-on-the-computation-of-dirichlet-normal-energy
#11
Jackson P Spradley, James D Pampush, Paul E Morse, Richard F Kay
OBJECTIVES: Dirichlet normal energy (DNE) is a metric of surface topography that has been used to evaluate the relationship between the surface complexity of primate cheek teeth and dietary categories. This study examines the effects of different 3D mesh retriangulation protocols on DNE. We examine how different protocols influence the DNE of a simple geometric shape-a hemisphere-to gain a more thorough understanding than can be achieved by investigating a complex biological surface such as a tooth crown...
February 20, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28218240/scaffolding-and-completing-genome-assemblies-in-real-time-with-nanopore-sequencing
#12
Minh Duc Cao, Son Hoang Nguyen, Devika Ganesamoorthy, Alysha G Elliott, Matthew A Cooper, Lachlan J M Coin
Third generation sequencing technologies provide the opportunity to improve genome assemblies by generating long reads spanning most repeat sequences. However, current analysis methods require substantial amounts of sequence data and computational resources to overcome the high error rates. Furthermore, they can only perform analysis after sequencing has completed, resulting in either over-sequencing, or in a low quality assembly due to under-sequencing. Here we present npScarf, which can scaffold and complete short read assemblies while the long read sequencing run is in progress...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28217137/reshaping-plant-biology-qualitative-and-quantitative-descriptors-for-plant-morphology
#13
REVIEW
Mathilde Balduzzi, Brad M Binder, Alexander Bucksch, Cynthia Chang, Lilan Hong, Anjali S Iyer-Pascuzzi, Christophe Pradal, Erin E Sparks
An emerging challenge in plant biology is to develop qualitative and quantitative measures to describe the appearance of plants through the integration of mathematics and biology. A major hurdle in developing these metrics is finding common terminology across fields. In this review, we define approaches for analyzing plant geometry, topology, and shape, and provide examples for how these terms have been and can be applied to plants. In leaf morphological quantifications both geometry and shape have been used to gain insight into leaf function and evolution...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28216431/optimizing-fmri-preprocessing-pipelines-for-block-design-tasks-as-a-function-of-age
#14
Nathan W Churchill, Pradeep Raamana, Robyn Spring, Stephen C Strother
Functional Magnetic Resonance Imaging (fMRI) is a powerful neuroimaging tool, which is often hampered by significant noise confounds. There is evidence that our ability to detect activations in task fMRI is highly dependent on the preprocessing steps used to control noise and artifact. However, the vast majority of studies examining preprocessing pipelines in fMRI have focused on young adults. Given the widespread use of fMRI for characterizing the neurobiology of aging, it is critical to examine how the impact of preprocessing choices varies as a function of age...
February 12, 2017: NeuroImage
https://www.readbyqxmd.com/read/28216288/home-automated-office-and-conventional-office-blood-pressure-as-predictors-of-cardiovascular-risk
#15
Emmanuel A Andreadis, Vasilios Papademetriou, Charalampia V Geladari, George N Kolyvas, Epameinondas T Angelopoulos, Konstantinos N Aronis
Automated office blood pressure (AOBP) has recently been shown to closely predict cardiovascular (CV) events in the elderly. Home blood pressure (HBP) has also been accepted as a valuable method in the prediction of CV disease. This study aimed to compare conventional office BP (OBP), HBP, and AOBP in order to evaluate their value in predicting CV events and deaths in hypertensives. We assessed 236 initially treatment naïve hypertensives, examined between 2009 and 2013. The end points were any CV and non-CV event including mortality, myocardial infarction, coronary heart disease, hospitalization for heart failure, severe arrhythmia, stroke, and intermittent claudication...
February 3, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28216043/multivariate-analyses-of-quality-metrics-for-crystal-structures-in-the-pdb-archive
#16
Chenghua Shao, Huanwang Yang, John D Westbrook, Jasmine Y Young, Christine Zardecki, Stephen K Burley
Following deployment of an augmented validation system by the Worldwide Protein Data Bank (wwPDB) partnership, the quality of crystal structures entering the PDB has improved. Of significance are improvements in quality measures now prominently displayed in the wwPDB validation report. Comparisons of PDB depositions made before and after introduction of the new reporting system show improvements in quality measures relating to pairwise atom-atom clashes, side-chain torsion angle rotamers, and local agreement between the atomic coordinate structure model and experimental electron density data...
February 15, 2017: Structure
https://www.readbyqxmd.com/read/28215811/intra-annual-variation-of-the-association-between-agricultural-best-management-practices-and-stream-nutrient-concentrations
#17
Nolan J T Pearce, Adam G Yates
Temporal variation may influence the ability of best management practices (BMPs) to mitigate the loss of agricultural pollutants to streams. Our goal was to assess variation in mitigation effects of BMPs by examining the associations between instream nutrient concentrations and the abundance and location of four structural BMPs over a hydrologic year. Water samples were collected monthly (Nov. 2013-Oct. 2014) in 15 headwater streams representing a gradient of BMP use in Southern Ontario, Canada. Partial least squares (PLS) regression models were used to associate two groups of collinear nutrient forms with the abundance and location of BMPs, antecedent precipitation and time of year...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28215769/quality-metrics-beyond-adenoma-detection-rate
#18
EDITORIAL
Brian R Weston, William A Ross
No abstract text is available yet for this article.
March 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28215632/ventricular-geometry-from-non-contrast-non-ecg-gated-ct-scans-an-imaging-marker-of-cardiopulmonary-disease-in-smokers
#19
Farbod N Rahaghi, Gonzalo Vegas-Sanchez-Ferrero, Jasleen K Minhas, Carolyn E Come, Isaac De La Bruere, James M Wells, Germán González, Surya P Bhatt, Brett E Fenster, Alejandro A Diaz, Puja Kohli, James C Ross, David A Lynch, Mark T Dransfield, Russel P Bowler, Maria J Ledesma-Carbayo, Raúl San José Estépar, George R Washko
RATIONALE AND OBJECTIVES: Imaging-based assessment of cardiovascular structure and function provides clinically relevant information in smokers. Non-cardiac-gated thoracic computed tomographic (CT) scanning is increasingly leveraged for clinical care and lung cancer screening. We sought to determine if more comprehensive measures of ventricular geometry could be obtained from CT using an atlas-based surface model of the heart. MATERIALS AND METHODS: Subcohorts of 24 subjects with cardiac magnetic resonance imaging (MRI) and 262 subjects with echocardiography were identified from COPDGene, a longitudinal observational study of smokers...
February 15, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28214667/effects-of-prior-testing-lasting-a-full-year-in-ncanda-adolescents-contributions-from-age-sex-socioeconomic-status-ethnicity-site-family-history-of-alcohol-or-drug-abuse-and-baseline-performance
#20
Edith V Sullivan, Ty Brumback, Susan F Tapert, Devin Prouty, Rosemary Fama, Wesley K Thompson, Sandra A Brown, Kevin Cummins, Ian M Colrain, Fiona C Baker, Duncan B Clark, Tammy Chung, Michael D De Bellis, Stephen R Hooper, Bonnie J Nagel, B Nolan Nichols, Weiwei Chu, Dongjin Kwon, Kilian M Pohl, Adolf Pfefferbaum
Longitudinal study provides a robust method for tracking developmental trajectories. Yet inherent problems of retesting pose challenges in distinguishing biological developmental change from prior testing experience. We examined factors potentially influencing change scores on 16 neuropsychological test composites over 1year in 568 adolescents in the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) project. The twice-minus-once-tested method revealed that performance gain was mainly attributable to testing experience (practice) with little contribution from predicted developmental effects...
January 24, 2017: Developmental Cognitive Neuroscience
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