Qian Xiao, Liying Shen, Haoling He, Xueying Wang, Yan Fu, Jun Ding, Furong Jiang, Jinfan Zhang, Zhejia Zhang, Alessandro Grecucci, Xiaoping Yi, Bihong T Chen
The neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. The study aimed to assess the alterations in neural activity within prefrontal cortex in adolescents with BPD and investigate the relationship of prefrontal activity with emotional regulation and cognitive function. This study enrolled 50 adolescents aged 12-17 years with BPD and 21 gender and age-matched healthy control (HC) participants. Study assessment for each participant included a brain resting-state functional MRI (rs-fMRI), clinical assessment questionnaires such as Borderline Personality Features Scale (BPFS), Difficulties in Emotion Regulation Scale (DERS), Ottawa Self-Injury Inventory and Childhood Trauma Questionnaire (CTQ) and cognitive testing with Stroop Color-Word Test (SCWT)...
April 20, 2024: European Child & Adolescent Psychiatry