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Monocyte chemoattractant protein-1 and cardiovascular disease

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https://www.readbyqxmd.com/read/28986223/inflammatory-response-to-mental-stress-and-mental-stress-induced-myocardial-ischemia
#1
Muhammad Hammadah, Samaah Sullivan, Brad Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T O'Neal, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Heval Mohamed Kelli, Mohamad Mazen Ghafeer, Pratik Pimple, Pratik Sandesara, Amit J Shah, Kareem Mohammed Hosny, Laura Ward, Yi-An Ko, Yan V Sun, Lei Weng, Michael Kutner, J Douglas Bremner, David S Sheps, Fabio Esteves, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia. METHODS: Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor...
October 3, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28919108/the-renin-angiotensin-system-regulates-neurodegeneration-in-a-mouse-model-of-optic-neuritis
#2
Xiaoli Guo, Kazuhiko Namekata, Atsuko Kimura, Chikako Harada, Takayuki Harada
The major role of the renin-angiotensin system (RAS), including that of angiotensin II (Ang II), the principal effector molecule, in the cardiovascular system is well known. Increasing evidence suggests that the RAS also plays a role in the development of autoimmune diseases. Optic neuritis (ie, inflammation of the optic nerve, with retinal ganglion cell loss) is strongly associated with multiple sclerosis. We investigated the effects of candesartan, an Ang II receptor antagonist, on optic neuritis in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis...
September 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28899902/pharmacological-inhibition-of-protein-tyrosine-phosphatase-1b-protects-against-atherosclerotic-plaque-formation-in-the-ldlr-mouse-model-of-atherosclerosis
#3
Dawn Thompson, Nicola Morrice, Louise Grant, Samantha Le Sommer, Emma K Lees, Nimesh Mody, Heather M Wilson, Mirela Delibegovic
Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence suggests a strong link between atherosclerosis and insulin resistance, due to impaired insulin receptor (IR) signalling. Here, we demonstrate that inhibiting the activity of protein tyrosine phosphatase 1B (PTP1B), the major negative regulator of the IR prevents and reverses atherosclerotic plaque formation in an LDLR(-/-) mouse model of atherosclerosis...
October 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28842423/activation-of-liver-x-receptor-suppresses-angiogenesis-via-induction-of-apod
#4
Chih-Jen Lai, Hsu-Chen Cheng, Ching-Yu Lin, Shih-Han Huang, Ting-Huan Chen, Chi-Jung Chung, Chung-Ho Chang, Horng-Dar Wang, Chih-Pin Chuu
Liver X receptors (LXRs) are important sensors and regulators for cholesterol, fatty acid, and glucose. LXRs play essential roles in the development and progression of cardiovascular diseases. We examined the effects of T0901317, a potent LXR agonist, on angiogenesis of human umbilical vein endothelial cells (HUVECs). Treatment with T0901317 inhibited the tube formation and migration of HUVECs as well as reduced the in vivo angiogenesis determined by chorioallantoic membrane assay. T0901317 stimulated gene and protein expression of LXR target gene apolipoprotein D (ApoD)...
August 21, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28683454/interactions-of-tlr4-and-ppar%C3%AE-dependent-on-ampk-signalling-pathway-contribute-to-anti-inflammatory-effects-of-vaccariae-hypaphorine-in-endothelial-cells
#5
Haijian Sun, Xuexue Zhu, Wei Lin, Yuetao Zhou, Weiwei Cai, Liying Qiu
Background /Aims: Accumulating evidence indicates that endothelial inflammation is one of the critical determinants in pathogenesis of atherosclerotic cardiovascular disease. Our previous studies had demonstrated that Vaccariae prevented high glucose or oxidative stress-triggered endothelial dysfunction in vitro. Very little is known about the potential effects of hypaphorine from Vaccariae seed on inflammatory response in endothelial cells. METHODS: In the present study, we evaluated the anti-inflammatory effects of Vaccariae hypaphorine (VH) on lipopolysaccharide (LPS)-challenged endothelial EA...
July 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28619112/docosahexaenoic-acid-regulates-vascular-endothelial-cell-function-and-prevents-cardiovascular-disease
#6
REVIEW
Kazuo Yamagata
Docosahexaenoic acid (DHA) is present in high concentrations in salmon, herring, and trout. Epidemiologic studies have shown that high dietary consumption of these and other oily fish is associated with reduced rates of myocardial infarction, atherosclerosis, and other ischemic pathologies. Atherosclerosis is induced by inflammation and can lead to acute cardiovascular events and extensive plaque. DHA inhibits the development of inflammation in endothelial cells, alters the function and regulation of vascular biomarkers, and reduces cardiovascular risk...
June 15, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28603045/arctigenin-improves-vascular-tone-and-decreases-inflammation-in-human-saphenous-vein
#7
Armond Daci, Burim Neziri, Shaip Krasniqi, Raif Cavolli, Rame Alaj, Giuseppe Danilo Norata, Giangiacomo Beretta
The goal of this study was to test the effects of bioactive phenylpropanoid dibenzylbutyrolactone lignan arctigenin (ATG) in vascular tone. Human bypass graft vessel, from a saphenous vein (SV), were set up in organ bath system and contracted with potassium chloride (KCl, 40mM). Two concentration-response curves of noradrenaline (NE) (10nM-100μM) separated with an incubation period of 30min without (Control) or with ATG (3-100μM) were established. Inhibitors of nitric oxide, prostaglandins, K(+) related channels or calcium influx were used to delineate the molecular mechanisms beyond ATG effects...
September 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28566450/monocyte-subtypes-and-the-ccr2-chemokine-receptor-in-cardiovascular-disease
#8
REVIEW
Carolina N França, Maria C O Izar, Marinella N S Hortêncio, Jônatas B do Amaral, Carlos E S Ferreira, Izabela D Tuleta, Francisco A H Fonseca
Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14(++)CD16(-)CCR2(++) cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14(++)CD16(+)CCR2(+)) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β)...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28410520/maternal-and-infant-inflammatory-markers-in-relation-to-prenatal-arsenic-exposure-in-a-u-s-pregnancy-cohort
#9
Shohreh F Farzan, Elizabeth B Brickley, Zhigang Li, Diane Gilbert-Diamond, Anala Gossai, Yu Chen, Caitlin G Howe, Thomas Palys, Margaret R Karagas
INTRODUCTION: Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. METHODS: We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood...
July 2017: Environmental Research
https://www.readbyqxmd.com/read/28371433/urinary-markers-of-fibrosis-and-risk-of-cardiovascular-events-and-death-in-kidney-transplant-recipients-the-favorit-trial
#10
M Park, R Katz, M G Shlipak, D Weiner, R Tracy, V Jotwani, J Hughes-Austin, F Gabbai, C Y Hsu, M Pfeffer, N Bansal, A Bostom, O Gutierrez, M Sarnak, A Levey, J H Ix
Cardiovascular risk remains high in kidney transplant recipients (KTRs) despite improved kidney function after transplant. Urinary markers of kidney fibrosis and injury may help to reveal mechanisms of this risk. In a case-cohort study among stable KTRs who participated in the FAVORIT trial, we measured four urinary proteins known to correlate with kidney tubulointerstitial fibrosis on biopsy (urine alpha 1 microglobulin [α1m], monocyte chemoattractant protein-1 [MCP-1], procollagen type I [PINP] and type III [PIIINP] N-terminal amino peptide) and evaluated associations with cardiovascular disease (CVD) events (n = 300) and death (n = 371)...
October 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28154178/green-tea-polyphenol-epigallocatechin-3-gallate-suppresses-toll-like-receptor-4-expression-via-up-regulation-of-e3-ubiquitin-protein-ligase-rnf216
#11
Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Kanako Takamatsu, Yuhui Huang, Jaehoon Bae, Shuya Yamashita, Motoki Murata, Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana
Toll-like receptor 4 (TLR4) plays an essential role in innate immunity through inflammatory cytokine induction. Recent studies demonstrated that the abnormal activation of TLR4 has a pivotal role in obesity-induced inflammation, which is associated with several diseases, including hyperinsulinemia, hypertriglyceridemia, and cardiovascular disease. Here we demonstrate that (-)-epigallocatechin-3-O-gallate, a natural agonist of the 67-kDa laminin receptor (67LR), suppressed TLR4 expression through E3 ubiquitin-protein ring finger protein 216 (RNF216) up-regulation...
March 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28153991/sex-based-differences-in-cardiometabolic-biomarkers
#12
Jeanney Lew, Monika Sanghavi, Colby R Ayers, Darren K McGuire, Torbjørn Omland, Dorothee Atzler, Maria O Gore, Ian Neeland, Jarett D Berry, Amit Khera, Anand Rohatgi, James A de Lemos
BACKGROUND: Few data are available comparing cardiovascular disease (CVD) biomarker profiles between women and men in the general population. We analyzed sex-based differences in multiple biomarkers reflecting distinct pathophysiological pathways, accounting for differences between women and men in CVD risk factors, body composition, and cardiac morphology. METHODS: A cross-sectional analysis was performed using data from the Dallas Heart Study, a multiethnic population-based study...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28012280/whey-and-casein-proteins-and-medium-chain-saturated-fatty-acids-from-milk-do-not-increase-low-grade-inflammation-in-abdominally-obese-adults
#13
Mette Bohl, Ann Bjørnshave, Søren Gregersen, Kjeld Hermansen
BACKGROUND: Low-grade inflammation is involved in the development of diabetes and cardiovascular disease (CVD). Inflammation can be modulated by dietary factors. Dairy products are rich in saturated fatty acids (SFA), which are known to possess pro-inflammatory properties. However, different fatty acid compositions may exert different effects. Other components such as milk proteins may exert anti-inflammatory properties which may compensate for the potential negative effects of SFAs. Generally, the available data suggest a neutral role of dairy product consumption on inflammation...
July 2016: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/27830026/puerarin-inhibits-cardiac-fibrosis-via-monocyte-chemoattractant-protein-mcp-1-and-the-transforming-growth-factor-%C3%AE-1-tgf-%C3%AE-1-pathway-in-myocardial-infarction-mice
#14
Zhiwen Tao, Yingbin Ge, Ningtian Zhou, Yunle Wang, Weili Cheng, Zhijian Yang
Transforming growth factor-β1 (TGF-β1) and inflammation play important roles in the cardiac fibrosis development associated with myocardial infarction (MI). Puerarin is wildly used for treatment of diabetes, cardiovascular disease and cerebrovascular disease in China, and recently some studies have shown its anti-cardiac fibrotic effect on myocardial hypertrophy. The purpose of our study was to determine whether puerarin has an anti-cardiac fibrotic effect after MI and find the potential mechanism. A mouse model of MI was established by standard LAD coronary artery ligation, and cardiac fibrosis was confirmed by Masson's staining and the expression of collagen I, III and α-SMA...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27751361/protein-bound-uremic-toxins-from-gut-microbiota-and-inflammatory-markers-in-chronic-kidney-disease
#15
Natália A Borges, Amanda F Barros, Lia S Nakao, Carla J Dolenga, Denis Fouque, Denise Mafra
OBJECTIVE: Protein-bound uremic toxins from gut microbiota tend to accumulate in chronic kidney disease (CKD) patients and are poorly removed by current dialysis techniques. These toxins induce inflammation and are associated with cardiovascular disease (CVD). The aim of this study was to report the relationship between uremic toxins and inflammatory and cardiovascular markers in CKD patients. DESIGN: This was a cross sectional study. SUBJECTS: Twenty-one nondialysis patients were included (43% men, 63...
November 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/27749218/serum-calprotectin-is-a-biomarker-of-carotid-atherosclerosis-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#16
Gabriela M Balarini, Eliana Zandonade, Leandro Tanure, Gilda A Ferreira, Wildner M Sardenberg, Érica V Serrano, Cleia C Dias, Túlio P Navarro, Hilde H Nordal, Piotr M Mydel, Johan G Brun, Karl A Brokstad, Eva Gerdts, Roland Jonsson, Valéria Valim
OBJECTIVES: We aimed to identify the association of carotid atherosclerosis with the traditional risk factors, disease features, cytokine profile, and calprotectin in patients with primary Sjögren's syndrome (pSS). METHODS: 63 primary pSS patients and 63 age- and sex-matched healthy controls underwent carotid ultrasound, clinical and laboratory examination. The presence of carotid plaques was taken as carotid atherosclerosis. The covariates of carotid atherosclerosis were identified in univariate and multivariate regressions...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27613367/large-artery-stiffness-is-associated-with-gamma-glutamyltransferase-in-young-healthy-adults-the-african-predict-study
#17
Melissa Maritz, Carla M T Fourie, Johannes M Van Rooyen, Sarah J Moss, Aletta E Schutte
Increased arterial stiffness is linked to cardiovascular disease development, particularly in black populations. Since detrimental health behaviors in young adults may affect arterial stiffness, we determined whether arterial stiffness associates with specific health behaviors, and whether it is more pronounced in young healthy black compared to white adults. We included 373 participants (49% black, 42% men) aged 20-30 years. Mean arterial pressure was higher for blacks than whites (P < .001), but carotid-femoral pulse wave velocity was similar (6...
October 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27592629/whitmania-pigra-whitman-extracts-inhibit-lipopolysaccharide-induced-rat-vascular-smooth-muscle-cells-migration-and-their-adhesion-ability-to-thp-1-and-raw-264-7-cells
#18
Shuaishuai Li, Long Cheng, Dengkun An, Shuliang Song, Hao Liang, Fulong Chu, Aiguo Ji
AIM: Atherosclerosis is a kind of chronic inflammatory disease. A crucial pathology change of atherosclerosis is the migration of activated VSMCs to the intima where they interact with leukocytes by expressing adhesion molecules, including intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Moreover, monocyte chemoattractant protein-1 (MCP-1) expressed by VSMCs plays an important role in recruiting monocytes and macrophages. Leech (Whitmania pigra Whitman) is a traditional Chinese medicine to treat cardiovascular diseases including atherosclerosis, however previous research has rarely reported the molecular mechanism for its curative effect...
March 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27574042/myeloid-derived-suppressor-cells-are-elevated-in-patients-with-psoriasis-and-produce-various-molecules
#19
Dan Ilkovitch, Laura K Ferris
Psoriasis is a debilitating chronic inflammatory disease. In addition to the characteristic effects on the skin, chronic inflammation associated with the disease is recognized to contribute to cardiovascular, hepatic and renal comorbidities. Immature myeloid regulatory cells, known as myeloid‑derived suppressor cells (MDSCs), have been demonstrated to accumulate in various diseases and chronic inflammatory states, including inflammatory bowel disease and various types of cancer. The results of the present study, obtained using flow cytometry and cell culture analysis of peripheral blood mononuclear cells from psoriasis and healthy patients, revealed that MDSC levels are significantly increased in the blood of patients with psoriasis compared with healthy controls...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27511707/synthesis-and-cardiovascular-protective-effects-of-quercetin-7-o-sialic-acid
#20
Hua Tian, Qingchao Liu, Shucun Qin, Chuanlong Zong, Ying Zhang, Shutong Yao, Nana Yang, Tao Guan, Shoudong Guo
Oxidative stress and inflammation play important roles in the pathogenesis of cardiovascular disease (CVD). Oxidative stress-induced desialylation is considered to be a primary step in atherogenic modification, and therefore, the attenuation of oxidative stress and/or inflammatory reactions may ameliorate CVD. In this study, quercetin 7-O-sialic acid (QA) was synthesized aiming to put together the cardiovascular protective effect of quercetin and the recently reported anti-oxidant and anti-atherosclerosis functions of N-acetylneuraminic acid...
January 2017: Journal of Cellular and Molecular Medicine
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