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Monocyte chemoattractant protein-1 and cardiovascular disease

Natália A Borges, Amanda F Barros, Lia S Nakao, Carla J Dolenga, Denis Fouque, Denise Mafra
OBJECTIVE: Protein-bound uremic toxins from gut microbiota tend to accumulate in chronic kidney disease (CKD) patients and are poorly removed by current dialysis techniques. These toxins induce inflammation and are associated with cardiovascular disease (CVD). The aim of this study was to report the relationship between uremic toxins and inflammatory and cardiovascular markers in CKD patients. DESIGN: This was a cross sectional study. SUBJECTS: Twenty-one nondialysis patients were included (43% men, 63...
November 2016: Journal of Renal Nutrition
Gabriela M Balarini, Eliana Zandonade, Leandro Tanure, Gilda A Ferreira, Wildner M Sardenberg, Érica V Serrano, Cleia C Dias, Túlio P Navarro, Hilde H Nordal, Piotr M Mydel, Johan G Brun, Karl A Brokstad, Eva Gerdts, Roland Jonsson, Valéria Valim
OBJECTIVES: We aimed to identify the association of carotid atherosclerosis with the traditional risk factors, disease features, cytokine profile, and calprotectin in patients with primary Sjögren's syndrome (pSS). METHODS: 63 primary pSS patients and 63 age- and sex-matched healthy controls underwent carotid ultrasound, clinical and laboratory examination. The presence of carotid plaques was taken as carotid atherosclerosis. The covariates of carotid atherosclerosis were identified in univariate and multivariate regressions...
September 8, 2016: Clinical and Experimental Rheumatology
Melissa Maritz, Carla M T Fourie, Johannes M Van Rooyen, Sarah J Moss, Aletta E Schutte
Increased arterial stiffness is linked to cardiovascular disease development, particularly in black populations. Since detrimental health behaviors in young adults may affect arterial stiffness, we determined whether arterial stiffness associates with specific health behaviors, and whether it is more pronounced in young healthy black compared to white adults. We included 373 participants (49% black, 42% men) aged 20-30 years. Mean arterial pressure was higher for blacks than whites (P < .001), but carotid-femoral pulse wave velocity was similar (6...
October 2016: Journal of the American Society of Hypertension: JASH
Shuaishuai Li, Long Cheng, Dengkun An, Shuliang Song, Hao Liang, Fulong Chu, Aiguo Ji
AIM: Atherosclerosis is a kind of chronic inflammatory disease. A crucial pathology change of atherosclerosis is the migration of activated VSMCs to the intima where they interact with leukocytes by expressing adhesion molecules, including intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Moreover, monocyte chemoattractant protein-1 (MCP-1) expressed by VSMCs plays an important role in recruiting monocytes and macrophages. Leech (Whitmania pigra Whitman) is a traditional Chinese medicine to treat cardiovascular diseases including atherosclerosis, however previous research has rarely reported the molecular mechanism for its curative effect...
September 2, 2016: Journal of Atherosclerosis and Thrombosis
Dan Ilkovitch, Laura K Ferris
Psoriasis is a debilitating chronic inflammatory disease. In addition to the characteristic effects on the skin, chronic inflammation associated with the disease is recognized to contribute to cardiovascular, hepatic and renal comorbidities. Immature myeloid regulatory cells, known as myeloid‑derived suppressor cells (MDSCs), have been demonstrated to accumulate in various diseases and chronic inflammatory states, including inflammatory bowel disease and various types of cancer. The results of the present study, obtained using flow cytometry and cell culture analysis of peripheral blood mononuclear cells from psoriasis and healthy patients, revealed that MDSC levels are significantly increased in the blood of patients with psoriasis compared with healthy controls...
October 2016: Molecular Medicine Reports
Hua Tian, Qingchao Liu, Shucun Qin, Chuanlong Zong, Ying Zhang, Shutong Yao, Nana Yang, Tao Guan, Shoudong Guo
Oxidative stress and inflammation play important roles in the pathogenesis of cardiovascular disease (CVD). Oxidative stress-induced desialylation is considered to be a primary step in atherogenic modification, and therefore, the attenuation of oxidative stress and/or inflammatory reactions may ameliorate CVD. In this study, quercetin 7-O-sialic acid (QA) was synthesized aiming to put together the cardiovascular protective effect of quercetin and the recently reported anti-oxidant and anti-atherosclerosis functions of N-acetylneuraminic acid...
August 11, 2016: Journal of Cellular and Molecular Medicine
Kenneth A Earle, Karima Zitouni, John Pepe, Maria Karaflou, James Godbold
BACKGROUND: Diabetes is the western world's leading cause of end-stage renal disease. Glucose-dependent, oxidative stress is linked to the development of renal inflammation and sclerosis, which, in animal models of diabetes, can be prevented by anti-oxidative treatment. Patients of non-Caucasian heritage have low activity of the selenoprotein, antioxidant enzyme, glutathione peroxidase (GPx) and its co-factor vitamin E, which may be linked to their increased propensity to developing end-stage renal disease...
2016: Journal of Translational Medicine
Rosa Casas, Emilio Sacanella, Mireia Urpí-Sardà, Dolores Corella, Olga Castañer, Rosa-María Lamuela-Raventos, Jordi Salas-Salvadó, Miguel-Angel Martínez-González, Emilio Ros, Ramon Estruch
BACKGROUND: The Mediterranean diet (MedDiet) has demonstrated short-term anti-inflammatory effects, but little is known about its long-term immunomodulatory properties. OBJECTIVE: Our goal was to assess the long-term effects of the MedDiet on inflammatory markers related to atherogenesis in adults at high risk of cardiovascular disease (CVD) compared with the effects of a low-fat diet (LFD). METHODS: We randomly assigned 165 high-risk participants (one-half men; mean age: 66 y) without overt CVD to 1 of 3 diets: a MedDiet supplemented with extra-virgin olive oil, a MedDiet supplemented with nuts, or an LFD...
September 2016: Journal of Nutrition
Syed Douhath Yousuf, Fouzia Rashid, Tahira Mattoo, Chander Shekhar, Syed Mudassar, M Afzal Zargar, Mohd Ashraf Ganie
STUDY OBJECTIVES: Polycystic ovary syndrome(PCOS), the commonest endocrinopathy of women, is a state of chronic low grade inflammation and is closely linked to type 2 diabetes mellitus and cardiovascular disease.Oral contraceptive pills(OCP's), is the usual first choice of treatment in women with PCOS.Because OCP use has been linked to the risk of venous thrombosis and there is limited data on impact of OCP use on inflammatory state of PCOS women our objective is to compare the levels of intercellular adhesion molecule-1(ICAM-1),tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1(MCP-1) between drug naive and OCP treated PCOS women...
July 2, 2016: Journal of Pediatric and Adolescent Gynecology
Robert Wolk, Marnie Bertolet, Prachi Singh, Maria M Brooks, Richard E Pratley, Robert L Frye, Arshag D Mooradian, Martin K Rutter, Andrew D Calvin, Bernard R Chaitman, Virend K Somers
OBJECTIVE: To evaluate the cardiovascular (CV) prognostic value of adipokines in a large prospective cohort of patients participating in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial. PATIENTS AND METHODS: The effects of the adipokine levels at baseline and change from baseline on the composite outcome (CV death, myocardial infarction, and stroke) were analyzed using unadjusted and fully adjusted Cox models in 2330 patients with type 2 diabetes and coronary artery disease who had participated in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial (from January 1, 2001, through December 1, 2008)...
July 2016: Mayo Clinic Proceedings
Á Aceña, A M Pello, R Carda, Ó Lorenzo, M L Gonzalez-Casaus, L M Blanco-Colio, J L Martín-Ventura, J Palfy, M Orejas, R Rábago, E Gonzalez-Parra, I Mahíllo-Fernández, J Farré, J Egido, J Tuñón
BACKGROUND: Abnormalities of mineral metabolism and inflammation may affect the cardiovascular system. We have assessed the relationship of left ventricular hypertrophy (LVH) with inflammation and mineral metabolism. METHODS: LVH was measured in 146 outpatients with stable coronary artery disease (SCAD) using echocardiography. Calcidiol (a vitamin D metabolite), parathyroid hormone (PTH), fibroblast growth factor-23, high-sensitivity C-reactive protein, MCP-1 (monocyte chemoattractant protein-1), galectin-3, NGAL (neutrophil gelatinase-associated lipocalin), and sTWEAK (soluble TNF-related weak inducer of apoptosis) plasma levels were studied...
2016: Journal of Nutrition, Health & Aging
Roberto Martín-Reyes, Juan Antonio Franco-Peláez, Óscar Lorenzo, María Luisa González-Casaus, Ana María Pello, Álvaro Aceña, Rocío Carda, José Luis Martín-Ventura, Luis Blanco-Colio, María Luisa Martín-Mariscal, Juan Martínez-Milla, Ricardo Villa-Bellosta, Antonio Piñero, Felipe Navarro, Jesús Egido, José Tuñón
BACKGROUND AND OBJECTIVES: We investigated the relationship of the Syntax Score (SS) and coronary artery calcification (CAC), with plasma levels of biomarkers related to cardiovascular damage and mineral metabolism, as there is sparse information in this field. METHODS: We studied 270 patients with coronary disease that had an acute coronary syndrome (ACS) six months before. Calcidiol, fibroblast growth factor-23, parathormone, phosphate and monocyte chemoattractant protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3, and N-terminal pro-brain natriuretic peptide [NT-proBNP] levels, among other biomarkers, were determined...
2016: PloS One
Xingxing Liu, Daxin Pang, Ting Yuan, Zhuang Li, Zhanjun Li, Mingjun Zhang, Wenzhi Ren, Hongsheng Ouyang, Xiaochun Tang
BACKGROUND: The consumption of n-3 polyunsaturated fatty acids (PUFAs) is important to human health, especially in cases of cardiovascular disease. Although beneficial effects of n-3 PUFAs have been observed in a number of studies, the mechanisms involved in these effects have yet to be discovered. METHODS: We generated hfat-1 transgenic pigs with traditional somatic cell nuclear transfer (SCNT) technology. The fatty acid composition in ear tissue of pigs were detected with gas chromatography...
2016: Lipids in Health and Disease
Hiroaki Sukegawa, Yuichiro Maekawa, Shinsuke Yuasa, Atsushi Anzai, Masaki Kodaira, Makoto Takei, Fumiya Sano, Ikuko Ueda, Takashi Kawakami, Kentaro Hayashida, Takashi Kohno, Shun Kohsaka, Takayuki Abe, Keiichi Fukuda
BACKGROUND: Besides its potent plasma cholesterol-lowering activity, statin treatment has several other important effects, including lowering high-sensitive C-reactive protein (hs-CRP), levels, and stabilizing risk factors of atherosclerosis, thereby reducing the risk of cardiovascular events. Our aim in this study was to identify how intensive statin therapy can affect plasma levels of inflammatory markers over the long term. METHODS AND RESULTS: We used a prospective, randomized, open blinded-endpoint design...
August 2016: Coronary Artery Disease
Kenshi Uemura, Hidekazu Kondo, Yumi Ishii, Mami Kobukata, Miho Haraguchi, Takaaki Imamura, Toyokazu Otsubo, Yuki Ikebe-Ebata, Ichitaro Abe, Reika Ayabe, Shotaro Saito, Kohei Aoki, Yasuko Nagano-Torigoe, Hidefumi Akioka, Tetsuji Shinohara, Yasushi Teshima, Takayuki Masaki, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
BACKGROUND AND OBJECTIVES: Recently, it was reported that mast cells (MCs) could underlie the mechanisms of several cardiovascular diseases. However, the role of MCs in diabetes-induced atrial fibrillation (AF) has not been notably investigated. We tested the hypothesis that MC deficiency attenuates hyperglycemia-induced AF in mice. METHODS AND RESULTS: Mast cell-deficient W/W(v)  mice, and congenic +/+ littermates (WT) were divided into either the vehicle (VEH)-injection group or the streptozotocin (STZ)-injection group (MCKO-VEH, MCKO-STZ, WT-VEH, and WT-STZ groups)...
August 2016: Journal of Cardiovascular Electrophysiology
Emi Nagata, Takahiko Oho
Streptococcus mutans, the primary etiologic agent of dental caries, can gain access to the bloodstream and has been associated with cardiovascular disease. However, the roles of S. mutans in inflammation in cardiovascular disease remain unclear. The aim of this study was to examine cytokine production induced by S. mutans in human aortic endothelial cells (HAECs) and to evaluate the participation of Toll-like receptors (TLRs) and cytoplasmic nucleotide-binding oligomerization domain (NOD)-like receptors in HAECs...
March 23, 2016: Molecular Oral Microbiology
Mette Bohl, Ann Bjørnshave, Søren Gregersen, Kjeld Hermansen
BACKGROUND: Low-grade inflammation is involved in the development of diabetes and cardiovascular disease (CVD). Inflammation can be modulated by dietary factors. Dairy products are rich in saturated fatty acids (SFA), which are known to possess pro-inflammatory properties. However, different fatty acid compositions may exert different effects. Other components such as milk proteins may exert anti-inflammatory properties which may compensate for the potential negative effects of SFAs. Generally, the available data suggest a neutral role of dairy product consumption on inflammation...
March 14, 2016: Review of Diabetic Studies: RDS
Joe W E Moss, Thomas S Davies, Iveta Garaiova, Sue F Plummer, Daryn R Michael, Dipak P Ramji
INTRODUCTION: Atherosclerosis is the underlying cause of cardiovascular disease that leads to more global mortalities each year than any other ailment. Consumption of active food ingredients such as phytosterols, omega-3 polyunsaturated fatty acids and flavanols are known to impart beneficial effects on cardiovascular disease although the combined actions of such agents in atherosclerosis is poorly understood. The aim of this study was to screen a nutritional supplement containing each of these active components for its anti-atherosclerotic effect on macrophages in vitro...
2016: PloS One
Francesco Paneni, Sarah Costantino, Nicolle Kränkel, Francesco Cosentino, Thomas F Lüscher
AIMS: Impaired tissue vascularization is a major determinant of cardiovascular disease (CVD) in the elderly. Accumulation of reactive oxygen species (ROS) may interfere with vascular repair, but the underlying mechanisms remain unknown. Early outgrowth cells (EOCs) play an important role in endothelial repair. We investigated whether key lifespan genes involved in ROS, i.e. the mitochondrial adaptor p66(Shc) and the AP-1 transcription factor JunD, contribute to age-related EOCs dysfunction in humans...
June 7, 2016: European Heart Journal
Nath Zungsontiporn, Raquel R Tello, Guangxiang Zhang, Brooks I Mitchell, Matthew Budoff, Kalpana J Kallianpur, Beau K Nakamoto, Sheila M Keating, Philip J Norris, Lishomwa C Ndhlovu, Scott A Souza, Cecilia M Shikuma, Dominic C Chow
BACKGROUND: Persistent inflammation and immune activation has been hypothesized to contribute to increased prevalence of subclinical atherosclerosis and cardiovascular disease (CVD) risk in patients with chronic HIV infection. In this study, we examined the correlation of peripheral monocyte subsets and soluble biomarkers of inflammation to coronary artery calcium (CAC) progression, as measured by cardiac computed tomography scan. METHODS: We conducted a longitudinal analysis utilizing baseline data of 78 participants with HIV infection on stable antiretroviral therapy (ART) in the Hawaii Aging with HIV-Cardiovascular study who had available baseline monocyte subset analysis as well as CAC measurement at baseline and at 2-year follow up...
2016: PloS One
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