keyword
Keywords Mcp-1 and mmp-9 and cardiovasc...

Mcp-1 and mmp-9 and cardiovascular disease

https://read.qxmd.com/read/32382533/the-role-of-a-selective-p2y-6-receptor-antagonist-mrs2578-on-the-formation-of-angiotensin-ii-induced-abdominal-aortic-aneurysms
#21
JOURNAL ARTICLE
Xiao Du, Shilan Zhang, Qunyan Xiang, Jingyuan Chen, Feng Tian, Jin Xu, Xin Li, Yuansheng Tan, Ling Liu
OBJECTIVE: The P2Y6 receptor has been shown to be involved in many cardiovascular diseases, including hypertension and atherosclerosis. The study is aimed at exploring the role of the P2Y6 receptor in Ang II-induced abdominal aortic aneurysm (AAA) formation in apolipoprotein E-deficient (apoE-/- ) mice by using its selective antagonist. METHODS: Male apoE-/- mice were fed with high-fat diet and infused with angiotensin (Ang) II (1000 ng/kg/min) for 4 weeks to induce AAA or saline as controls...
2020: BioMed Research International
https://read.qxmd.com/read/30302090/serum-matrix-metalloproteinase-9-and-macrophage-migration-inhibitory-factor-mif-are-increased-in-young-healthy-nonobese-subjects-with-positive-family-history-of-type-2-diabetes
#22
JOURNAL ARTICLE
Agnieszka Nikołajuk, Natalia Matulewicz, Magdalena Stefanowicz, Monika Karczewska-Kupczewska
Insulin resistance increases the risk for cardiovascular disease (CVD) even in the absence of classic risk factors, such as hyperglycemia, hypertension, dyslipidemia, and obesity. Low-grade chronic inflammatory state is associated both with insulin resistance and atherosclerosis. An increased circulating level of proinflammatory proatherogenic factors and biomarkers of endothelial activation was observed in diabetes and CVD. The aim of our study was to assess serum proatherogenic and proinflammatory factors in young healthy nonobese subjects with positive family history of type 2 diabetes...
2018: International Journal of Endocrinology
https://read.qxmd.com/read/30172946/posttraumatic-stress-disorder-is-associated-with-enhanced-interleukin-6-response-to-mental-stress-in-subjects-with-a-recent-myocardial-infarction
#23
JOURNAL ARTICLE
Bruno B Lima, Muhammad Hammadah, Kobina Wilmot, Brad D Pearce, Amit Shah, Oleksiy Levantsevych, Belal Kaseer, Malik Obideen, Mohamad Mazen Gafeer, Jeong Hwan Kim, Samaah Sullivan, Tené T Lewis, Lei Weng, Lisa Elon, Lian Li, J Douglas Bremner, Paolo Raggi, Arshed Quyyumi, Viola Vaccarino
BACKGROUND: Posttraumatic Stress Disorder (PTSD) is prevalent among patients who survived an acute coronary syndrome, and is associated with adverse outcomes, but the mechanisms underlying these associations are unclear. Individuals with PTSD have enhanced sensitivity of the noradrenergic system to stress which may lead to immune activation. We hypothesized that survivors of a myocardial infarction (MI) who have PTSD would show an enhanced inflammatory response to acute psychological stress compared to those without PTSD...
January 2019: Brain, Behavior, and Immunity
https://read.qxmd.com/read/29884547/the-incretin-hormone-gip-is-upregulated-in-patients-with-atherosclerosis-and-stabilizes-plaques-in-apoe-mice-by-blocking-monocyte-macrophage-activation
#24
JOURNAL ARTICLE
Florian Kahles, Ana Liberman, Constantin Halim, Matthias Rau, Julia Möllmann, Robert Werner Mertens, Marcia Rückbeil, Irmgard Diepolder, Benedikt Walla, Sebastian Diebold, Mathias Burgmaier, Corinna Lebherz, Nikolaus Marx, Michael Lehrke
OBJECTIVE: The incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by the gut after food intake leading to pancreatic insulin secretion and glucose lowering. Beyond its role in glucose control, GLP-1 was found in mice and men to beneficially modulate the process of atherosclerosis, which has been linked to improved cardiovascular outcome of patients with diabetes at high cardiovascular risk treated with GLP-1 receptor agonists...
August 2018: Molecular Metabolism
https://read.qxmd.com/read/29464937/vascular-dysfunction-elicited-by-a-cross-talk-between-periaortic-adipose-tissue-and-the-vascular-wall-is-reversed-by-pioglitazone
#25
JOURNAL ARTICLE
Isabel Quesada, Jimena Cejas, Rodrigo García, Beatriz Cannizzo, Analía Redondo, Claudia Castro
AIM: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers...
June 2018: Cardiovascular Therapeutics
https://read.qxmd.com/read/28986223/inflammatory-response-to-mental-stress-and-mental-stress-induced-myocardial-ischemia
#26
JOURNAL ARTICLE
Muhammad Hammadah, Samaah Sullivan, Brad Pearce, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Samman Tahhan, Wesley T O'Neal, Malik Obideen, Ayman Alkhoder, Naser Abdelhadi, Heval Mohamed Kelli, Mohamad Mazen Ghafeer, Pratik Pimple, Pratik Sandesara, Amit J Shah, Kareem Mohammed Hosny, Laura Ward, Yi-An Ko, Yan V Sun, Lei Weng, Michael Kutner, J Douglas Bremner, David S Sheps, Fabio Esteves, Paolo Raggi, Viola Vaccarino, Arshed A Quyyumi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia. METHODS: Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor...
February 2018: Brain, Behavior, and Immunity
https://read.qxmd.com/read/28957799/epigallocatechin-3-gallate-inhibits-matrix-metalloproteinase-9-and-monocyte-chemotactic-protein-1-expression-through-the-67-%C3%AE%C2%BAda-laminin-receptor-and-the-tlr4-mapk-nf-%C3%AE%C2%BAb-signalling-pathway-in-lipopolysaccharide-induced-macrophages
#27
JOURNAL ARTICLE
Ya-Fei Li, Hao Wang, Yi Fan, Hao-Jie Shi, Qi-Ming Wang, Bing-Rui Chen, Mohammad Reeaze Khurwolah, Qing-Qing Long, Si-Bo Wang, Ze-Mu Wang, Lian-Sheng Wang
BACKGROUND/AIMS: Epigallocatechin-3-gallate (EGCG), a major catechin found in green tea, has been shown to prevent cardiovascular diseases. Previously, Matrix metalloproteinase-9 (MMP-9), monocyte chemotactic protein-1 (MCP-1) and toll-like receptor 4 (TLR4) were confirmed to play an important role in atherosclerosis and plaque instability. Both TLR4 and its negative regulator, Toll-interacting protein (Tollip), could be mediated by EGCG. The present study aimed to examine the effect of physiological concentration of EGCG (1 µM) on the expression of MMP-9 and MCP-1 in lipopolysaccharide (LPS)-induced macrophages and the potential mechanisms underlying its actions...
2017: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/27079193/metabolically-inactive-glucagon-like-peptide-1-9-36-amide-confers-selective-protective-actions-against-post-myocardial-infarction-remodelling
#28
JOURNAL ARTICLE
Emma Robinson, Mitchel Tate, Samuel Lockhart, Claire McPeake, Karla M O'Neill, Kevin S Edgar, Danielle Calderwood, Brian D Green, Barbara J McDermott, David J Grieve
BACKGROUND: Glucagon-like peptide-1 (GLP-1) therapies are routinely used for glycaemic control in diabetes and their emerging cardiovascular actions have been a major recent research focus. In addition to GLP-1 receptor activation, the metabolically-inactive breakdown product, GLP-1(9-36)amide, also appears to exert notable cardiovascular effects, including protection against acute cardiac ischaemia. Here, we specifically studied the influence of GLP-1(9-36)amide on chronic post-myocardial infarction (MI) remodelling, which is a major driver of heart failure progression...
April 14, 2016: Cardiovascular Diabetology
https://read.qxmd.com/read/26965176/adiponectin-improves-nf-%C3%AE%C2%BAb-mediated-inflammation-and-abates-atherosclerosis-progression-in-apolipoprotein-e-deficient-mice
#29
JOURNAL ARTICLE
Xuemei Wang, Qingjie Chen, Hongwei Pu, Qin Wei, Mingjun Duan, Chun Zhang, Tao Jiang, Xi Shou, Jianlong Zhang, Yining Yang
BACKGROUND: Atherosclerosis is a common pathological basis of cardiovascular disease. Adiponectin (APN) has been shown to have an anti-atherosclerosis effect, and the underlying mechanisms, however, are largely unknown. Nuclear factor κB (NF-κB) has also been regarded as a proatherogenic factor, mainly because of its regulation of a variety of the proinflammatory genes linked to atherosclerosis. It was hypothesized that the inhibitory effects of adiponectin on the atherosclerosis is through the inhibition of NF-κB signaling pathway...
February 18, 2016: Lipids in Health and Disease
https://read.qxmd.com/read/26707750/effects-of-korean-red-ginseng-panax-ginseng-on-obesity-and-adipose-inflammation-in-ovariectomized-mice
#30
JOURNAL ARTICLE
Hyunghee Lee, Jeonghyun Choi, Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (ginseng, Panax ginseng C.A. Meyer) is a famous traditional drug used in Korea for the treatment and prevention of obesity, type 2 diabetes, cancer, and liver and cardiovascular diseases. Menopause is strongly associated with many of the aforementioned metabolic diseases and increased visceral obesity. The aims of this study were to investigate whether ginseng inhibits obesity and related disorders in ovariectomized (OVX) C57BL/6J mice, which is a mouse model of postmenopausal women, and to determine the mechanism of action involved in this process...
February 3, 2016: Journal of Ethnopharmacology
https://read.qxmd.com/read/26632487/staphylococcal-ssl5-induced-platelet-microparticles-provoke-proinflammatory-responses-via-the-cd40-traf6-nf%C3%AE%C2%BAb-signalling-pathway-in-monocytes
#31
JOURNAL ARTICLE
Jun-Jie Bei, Chuan Liu, Song Peng, Cheng-Hai Liu, Wei-Bo Zhao, Xiao-Long Qu, Qiang Chen, Zhou Zhou, Zheng-Ping Yu, Karlheinz Peter, Hou-Yuan Hu
Pathogens-induced platelet activation contributes to inflammation in cardiovascular diseases, but underlying mechanisms remain elusive. Staphylococcal superantigen-like protein 5 (SSL5) is a known activator of platelets. Here we examined whether SSL5 is implicated in Staphylococcus aureus (S. aureus)-induced inflammation and potential mechanisms involved. As expected, we show that SSL5 activates human platelets and induces generation of platelet microparticles (PMPs). Flow cytometry and scanning electron microscopy studies demonstrate that SSL5-induced PMPs (SSL5-PMPs) bind to monocytes, causing aggregate formation...
March 2016: Thrombosis and Haemostasis
https://read.qxmd.com/read/26140943/investigating-the-effect-of-a-single-infusion-of-reconstituted-high-density-lipoprotein-in-patients-with-symptomatic-carotid-plaques
#32
RANDOMIZED CONTROLLED TRIAL
Hosaam Nasr, Evelyn Torsney, Robin N Poston, Lawrence Hayes, David C Gaze, Russell Basser, Matthew M Thompson, Ian M Loftus, Gillian W Cockerill
BACKGROUND: Elevation of plasma high-density lipoprotein (HDL) cholesterol concentration reduces cardiovascular mortality and morbidity. HDLs have been shown to possess acute anti-inflammatory, antioxidant, and antithrombotic properties. We hypothesize that HDL therapy can acutely alter local and systemic manifestations of plaque instability. METHODS: Forty patients with early symptomatic carotid disease were randomized to either receive reconstituted HDL (rHDL) 40 mg/kg (n = 20) or placebo (n = 20)...
October 2015: Annals of Vascular Surgery
https://read.qxmd.com/read/26046630/chronic-internal-exposure-to-low-dose-137cs-induces-positive-impact-on-the-stability-of-atherosclerotic-plaques-by-reducing-inflammation-in-apoe-mice
#33
JOURNAL ARTICLE
Clélia Le Gallic, Yohann Phalente, Line Manens, Isabelle Dublineau, Marc Benderitter, Yann Gueguen, Stephanie Lehoux, Teni G Ebrahimian
After Chernobyl and Fukushima Daï Chi, two major nuclear accidents, large amounts of radionuclides were released in the environment, mostly caesium 137 (137Cs). Populations living in contaminated territories are chronically exposed to radionuclides by ingestion of contaminated food. However, questions still remain regarding the effects of low dose ionizing radiation exposure on the development and progression of cardiovascular diseases. We therefore investigated the effects of a chronic internal exposure to 137Cs on atherosclerosis in predisposed ApoE-/- mice...
2015: PloS One
https://read.qxmd.com/read/25437887/inflammation-in-childhood-type-1-diabetes-influence-of-glycemic-control
#34
JOURNAL ARTICLE
Martin Heier, Hanna Dis Margeirsdottir, Cathrine Brunborg, Kristian F Hanssen, Knut Dahl-Jørgensen, Ingebjørg Seljeflot
OBJECTIVE: Patients with type 1 diabetes have increased mortality from cardiovascular disease, and inflammation is important in the development of atherosclerosis. Our aim was to evaluate the extent of inflammation and the influence of glycemic control in the early phases of atherosclerosis in childhood type 1 diabetes. MATERIALS AND METHODS: A population based cohort representative of all children with type 1 diabetes in Norway was studied. Diabetes patients (n = 314) were compared to healthy controls (n = 120), aged 8-18 years...
January 2015: Atherosclerosis
https://read.qxmd.com/read/25084093/ginsenoside-rb3-protects-cardiomyocytes-against-ischemia-reperfusion-injury-via-the-inhibition-of-jnk-mediated-nf-%C3%AE%C2%BAb-pathway-a-mouse-cardiomyocyte-model
#35
JOURNAL ARTICLE
Lijia Ma, Huimin Liu, Zulong Xie, Shuang Yang, Wei Xu, Jingbo Hou, Bo Yu
Ginsenoside Rb3 is extracted from the plant Panax ginseng and plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. NF-κB is an important transcription factor involved in I/R injury. However, the underlying mechanism of ginsenoside Rb3 in myocardial I/R injury remains poorly understood. In the current study, a model of myocardial I/R injury was induced via oxygen and glucose deprivation (OGD) followed by reperfusion (OGD-Rep) in mouse cardiac myoblast H9c2 cells...
2014: PloS One
https://read.qxmd.com/read/24891839/pepsin-pancreatin-protein-hydrolysates-from-extruded-amaranth-inhibit-markers-of-atherosclerosis-in-lps-induced-thp-1-macrophages-like-human-cells-by-reducing-expression-of-proteins-in-lox-1-signaling-pathway
#36
JOURNAL ARTICLE
Alvaro Montoya-Rodríguez, Jorge Milán-Carrillo, Vermont P Dia, Cuauhtémoc Reyes-Moreno, Elvira González de Mejía
BACKGROUND: Atherosclerosis is considered a progressive disease that affects arteries that bring blood to the heart, to the brain and to the lower end. It derives from endothelial dysfunction and inflammation, which play an important role in the thrombotic complications of atherosclerosis. Cardiovascular disease is the leading cause of death around the world and one factor that can contribute to its progression and prevention is diet. Our previous study found that amaranth hydrolysates inhibited LPS-induced inflammation in human and mouse macrophages by preventing activation of NF-κB signaling...
2014: Proteome Science
https://read.qxmd.com/read/24126878/higher-levels-of-advanced-glycation-endproducts-in-human-carotid-atherosclerotic-plaques-are-associated-with-a-rupture-prone-phenotype
#37
JOURNAL ARTICLE
Nordin M J Hanssen, Kristiaan Wouters, Maya S Huijberts, Marion J Gijbels, Judith C Sluimer, Jean L J M Scheijen, Sylvia Heeneman, Erik A L Biessen, Mat J A P Daemen, Michael Brownlee, Dominique P de Kleijn, Coen D A Stehouwer, Gerard Pasterkamp, Casper G Schalkwijk
AIMS: Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation endproducts (AGEs) and their major precursor methylglyoxal are formed during high metabolic activity and can have detrimental effects on cellular function and may induce cell death. Therefore, we investigated whether plaque AGEs are increased in human carotid rupture-prone plaques and are associated with plaque inflammation and necrotic core formation...
May 2014: European Heart Journal
https://read.qxmd.com/read/23983803/the-effect-of-sodium-tanshinone-iia-sulfate-and-simvastatin-on-elevated-serum-levels-of-inflammatory-markers-in-patients-with-coronary-heart-disease-a-study-protocol-for-a-randomized-controlled-trial
#38
JOURNAL ARTICLE
Qinghua Shang, Hanjay Wang, Siming Li, Hao Xu
UNLABELLED: Background. Coronary heart disease (CHD) due to atherosclerotic inflammation remains a significant threat to global health despite the success of the lipid-lowering, anti-inflammatory statins. Tanshinone IIA, a potent anti-inflammatory compound derived from Traditional Chinese Medicine (TCM), may be able to supplement statins by further reducing levels of circulating inflammatory markers correlated to cardiovascular risk. Here, we present the protocol of a randomized controlled trial (RCT) that will investigate the synergistic effect of sodium tanshinone IIA sulfate and simvastatin on reducing elevated inflammatory markers in patients with CHD...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/23190520/high-prevalence-of-anti-apolipoprotein-a-1-autoantibodies-in-maintenance-hemodialysis-and-association-with-dialysis-vintage
#39
JOURNAL ARTICLE
Menno Pruijm, Jan Schmidtko, Anthony Aho, Sabrina Pagano, Pascale Roux-Lombard, Daniel Teta, Michel Burnier, Nicolas Vuilleumier
Autoantibodies to apolipoprotein/A-1 (anti-ApoA-1 IgG) have pro-atherogenic properties in patients at high cardiovascular risk, but its prevalence in patients with end-stage kidney disease is unknown. The aims of this single-center, cross-sectional study were to assess the prevalence of anti-ApoA-1 antibodies in patients on maintenance hemodialysis (MHD), and to examine its correlation with inflammatory biomarkers related to atherosclerotic plaque vulnerability and dialysis vintage. To this purpose, anti-ApoA-1 IgG levels and the concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), metalloproteinase-9 (MMP-9), tumor necrosis factor-α, and C-reactive protein (CRP) were assessed in the sera of 66 MHD patients (mean age: 68 ± 14 years, 36% women, 32% diabetics)...
December 2012: Therapeutic Apheresis and Dialysis
https://read.qxmd.com/read/22985398/effect-of-rosemarinus-officinalis-l-on-mmp-9-mcp-1-levels-and-cell-migration-in-raw-264-7-and-smooth-muscle-cells
#40
JOURNAL ARTICLE
In Gyeong Chae, Mi Hee Yu, Nam-Kyung Im, Young Tae Jung, Jinho Lee, Kyung-Soo Chun, In-Seon Lee
Atherosclerosis is a chronic and progressive inflammatory disease. Novel anti-inflammatory therapies may have promise as treatment strategies for cardiovascular risk reduction. Rosemary (Rosemarinus officinalis L.) has been used in folk medicine to treat headaches, epilepsy, poor circulation, and many other ailments. It was found that rosemary could act as a stimulant and mild analgesic and could reduce inflammation. However, the mechanisms underlying the anti-inflammatory and antiatherosclerotic effects of rosemary need more study...
October 2012: Journal of Medicinal Food
keyword
keyword
57029
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.