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Mcp-1 and mmp-9 and cardiovascular disease

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https://www.readbyqxmd.com/read/27079193/metabolically-inactive-glucagon-like-peptide-1-9-36-amide-confers-selective-protective-actions-against-post-myocardial-infarction-remodelling
#1
Emma Robinson, Mitchel Tate, Samuel Lockhart, Claire McPeake, Karla M O'Neill, Kevin S Edgar, Danielle Calderwood, Brian D Green, Barbara J McDermott, David J Grieve
BACKGROUND: Glucagon-like peptide-1 (GLP-1) therapies are routinely used for glycaemic control in diabetes and their emerging cardiovascular actions have been a major recent research focus. In addition to GLP-1 receptor activation, the metabolically-inactive breakdown product, GLP-1(9-36)amide, also appears to exert notable cardiovascular effects, including protection against acute cardiac ischaemia. Here, we specifically studied the influence of GLP-1(9-36)amide on chronic post-myocardial infarction (MI) remodelling, which is a major driver of heart failure progression...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26965176/adiponectin-improves-nf-%C3%AE%C2%BAb-mediated-inflammation-and-abates-atherosclerosis-progression-in-apolipoprotein-e-deficient-mice
#2
Xuemei Wang, Qingjie Chen, Hongwei Pu, Qin Wei, Mingjun Duan, Chun Zhang, Tao Jiang, Xi Shou, Jianlong Zhang, Yining Yang
BACKGROUND: Atherosclerosis is a common pathological basis of cardiovascular disease. Adiponectin (APN) has been shown to have an anti-atherosclerosis effect, and the underlying mechanisms, however, are largely unknown. Nuclear factor κB (NF-κB) has also been regarded as a proatherogenic factor, mainly because of its regulation of a variety of the proinflammatory genes linked to atherosclerosis. It was hypothesized that the inhibitory effects of adiponectin on the atherosclerosis is through the inhibition of NF-κB signaling pathway...
2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/26707750/effects-of-korean-red-ginseng-panax-ginseng-on-obesity-and-adipose-inflammation-in-ovariectomized-mice
#3
Hyunghee Lee, Jeonghyun Choi, Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (ginseng, Panax ginseng C.A. Meyer) is a famous traditional drug used in Korea for the treatment and prevention of obesity, type 2 diabetes, cancer, and liver and cardiovascular diseases. Menopause is strongly associated with many of the aforementioned metabolic diseases and increased visceral obesity. The aims of this study were to investigate whether ginseng inhibits obesity and related disorders in ovariectomized (OVX) C57BL/6J mice, which is a mouse model of postmenopausal women, and to determine the mechanism of action involved in this process...
February 3, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26632487/staphylococcal-ssl5-induced-platelet-microparticles-provoke-proinflammatory-responses-via-the-cd40-traf6-nf%C3%AE%C2%BAb-signalling-pathway-in-monocytes
#4
Jun-Jie Bei, Chuan Liu, Song Peng, Cheng-Hai Liu, Wei-Bo Zhao, Xiao-Long Qu, Qiang Chen, Zhou Zhou, Zheng-Ping Yu, Karlheinz Peter, Hou-Yuan Hu
Pathogens-induced platelet activation contributes to inflammation in cardiovascular diseases, but underlying mechanisms remain elusive. Staphylococcal superantigen-like protein 5 (SSL5) is a known activator of platelets. Here we examined whether SSL5 is implicated in Staphylococcus aureus (S. aureus)-induced inflammation and potential mechanisms involved. As expected, we show that SSL5 activates human platelets and induces generation of platelet microparticles (PMPs). Flow cytometry and scanning electron microscopy studies demonstrate that SSL5-induced PMPs (SSL5-PMPs) bind to monocytes, causing aggregate formation...
March 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/26140943/investigating-the-effect-of-a-single-infusion-of-reconstituted-high-density-lipoprotein-in-patients-with-symptomatic-carotid-plaques
#5
RANDOMIZED CONTROLLED TRIAL
Hosaam Nasr, Evelyn Torsney, Robin N Poston, Lawrence Hayes, David C Gaze, Russell Basser, Matthew M Thompson, Ian M Loftus, Gillian W Cockerill
BACKGROUND: Elevation of plasma high-density lipoprotein (HDL) cholesterol concentration reduces cardiovascular mortality and morbidity. HDLs have been shown to possess acute anti-inflammatory, antioxidant, and antithrombotic properties. We hypothesize that HDL therapy can acutely alter local and systemic manifestations of plaque instability. METHODS: Forty patients with early symptomatic carotid disease were randomized to either receive reconstituted HDL (rHDL) 40 mg/kg (n = 20) or placebo (n = 20)...
October 2015: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/26046630/chronic-internal-exposure-to-low-dose-137cs-induces-positive-impact-on-the-stability-of-atherosclerotic-plaques-by-reducing-inflammation-in-apoe-mice
#6
Clélia Le Gallic, Yohann Phalente, Line Manens, Isabelle Dublineau, Marc Benderitter, Yann Gueguen, Stephanie Lehoux, Teni G Ebrahimian
After Chernobyl and Fukushima Daï Chi, two major nuclear accidents, large amounts of radionuclides were released in the environment, mostly caesium 137 (137Cs). Populations living in contaminated territories are chronically exposed to radionuclides by ingestion of contaminated food. However, questions still remain regarding the effects of low dose ionizing radiation exposure on the development and progression of cardiovascular diseases. We therefore investigated the effects of a chronic internal exposure to 137Cs on atherosclerosis in predisposed ApoE-/- mice...
2015: PloS One
https://www.readbyqxmd.com/read/25437887/inflammation-in-childhood-type-1-diabetes-influence-of-glycemic-control
#7
Martin Heier, Hanna Dis Margeirsdottir, Cathrine Brunborg, Kristian F Hanssen, Knut Dahl-Jørgensen, Ingebjørg Seljeflot
OBJECTIVE: Patients with type 1 diabetes have increased mortality from cardiovascular disease, and inflammation is important in the development of atherosclerosis. Our aim was to evaluate the extent of inflammation and the influence of glycemic control in the early phases of atherosclerosis in childhood type 1 diabetes. MATERIALS AND METHODS: A population based cohort representative of all children with type 1 diabetes in Norway was studied. Diabetes patients (n = 314) were compared to healthy controls (n = 120), aged 8-18 years...
January 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25084093/ginsenoside-rb3-protects-cardiomyocytes-against-ischemia-reperfusion-injury-via-the-inhibition-of-jnk-mediated-nf-%C3%AE%C2%BAb-pathway-a-mouse-cardiomyocyte-model
#8
Lijia Ma, Huimin Liu, Zulong Xie, Shuang Yang, Wei Xu, Jingbo Hou, Bo Yu
Ginsenoside Rb3 is extracted from the plant Panax ginseng and plays important roles in cardiovascular diseases, including myocardial ischemia-reperfusion (I/R) injury. NF-κB is an important transcription factor involved in I/R injury. However, the underlying mechanism of ginsenoside Rb3 in myocardial I/R injury remains poorly understood. In the current study, a model of myocardial I/R injury was induced via oxygen and glucose deprivation (OGD) followed by reperfusion (OGD-Rep) in mouse cardiac myoblast H9c2 cells...
2014: PloS One
https://www.readbyqxmd.com/read/24891839/pepsin-pancreatin-protein-hydrolysates-from-extruded-amaranth-inhibit-markers-of-atherosclerosis-in-lps-induced-thp-1-macrophages-like-human-cells-by-reducing-expression-of-proteins-in-lox-1-signaling-pathway
#9
Alvaro Montoya-Rodríguez, Jorge Milán-Carrillo, Vermont P Dia, Cuauhtémoc Reyes-Moreno, Elvira González de Mejía
BACKGROUND: Atherosclerosis is considered a progressive disease that affects arteries that bring blood to the heart, to the brain and to the lower end. It derives from endothelial dysfunction and inflammation, which play an important role in the thrombotic complications of atherosclerosis. Cardiovascular disease is the leading cause of death around the world and one factor that can contribute to its progression and prevention is diet. Our previous study found that amaranth hydrolysates inhibited LPS-induced inflammation in human and mouse macrophages by preventing activation of NF-κB signaling...
2014: Proteome Science
https://www.readbyqxmd.com/read/24126878/higher-levels-of-advanced-glycation-endproducts-in-human-carotid-atherosclerotic-plaques-are-associated-with-a-rupture-prone-phenotype
#10
Nordin M J Hanssen, Kristiaan Wouters, Maya S Huijberts, Marion J Gijbels, Judith C Sluimer, Jean L J M Scheijen, Sylvia Heeneman, Erik A L Biessen, Mat J A P Daemen, Michael Brownlee, Dominique P de Kleijn, Coen D A Stehouwer, Gerard Pasterkamp, Casper G Schalkwijk
AIMS: Rupture-prone atherosclerotic plaques are characterized by inflammation and a large necrotic core. Inflammation is linked to high metabolic activity. Advanced glycation endproducts (AGEs) and their major precursor methylglyoxal are formed during high metabolic activity and can have detrimental effects on cellular function and may induce cell death. Therefore, we investigated whether plaque AGEs are increased in human carotid rupture-prone plaques and are associated with plaque inflammation and necrotic core formation...
May 2014: European Heart Journal
https://www.readbyqxmd.com/read/23983803/the-effect-of-sodium-tanshinone-iia-sulfate-and-simvastatin-on-elevated-serum-levels-of-inflammatory-markers-in-patients-with-coronary-heart-disease-a-study-protocol-for-a-randomized-controlled-trial
#11
Qinghua Shang, Hanjay Wang, Siming Li, Hao Xu
UNLABELLED: Background. Coronary heart disease (CHD) due to atherosclerotic inflammation remains a significant threat to global health despite the success of the lipid-lowering, anti-inflammatory statins. Tanshinone IIA, a potent anti-inflammatory compound derived from Traditional Chinese Medicine (TCM), may be able to supplement statins by further reducing levels of circulating inflammatory markers correlated to cardiovascular risk. Here, we present the protocol of a randomized controlled trial (RCT) that will investigate the synergistic effect of sodium tanshinone IIA sulfate and simvastatin on reducing elevated inflammatory markers in patients with CHD...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/23190520/high-prevalence-of-anti-apolipoprotein-a-1-autoantibodies-in-maintenance-hemodialysis-and-association-with-dialysis-vintage
#12
Menno Pruijm, Jan Schmidtko, Anthony Aho, Sabrina Pagano, Pascale Roux-Lombard, Daniel Teta, Michel Burnier, Nicolas Vuilleumier
Autoantibodies to apolipoprotein/A-1 (anti-ApoA-1 IgG) have pro-atherogenic properties in patients at high cardiovascular risk, but its prevalence in patients with end-stage kidney disease is unknown. The aims of this single-center, cross-sectional study were to assess the prevalence of anti-ApoA-1 antibodies in patients on maintenance hemodialysis (MHD), and to examine its correlation with inflammatory biomarkers related to atherosclerotic plaque vulnerability and dialysis vintage. To this purpose, anti-ApoA-1 IgG levels and the concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), metalloproteinase-9 (MMP-9), tumor necrosis factor-α, and C-reactive protein (CRP) were assessed in the sera of 66 MHD patients (mean age: 68 ± 14 years, 36% women, 32% diabetics)...
December 2012: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/22985398/effect-of-rosemarinus-officinalis-l-on-mmp-9-mcp-1-levels-and-cell-migration-in-raw-264-7-and-smooth-muscle-cells
#13
In Gyeong Chae, Mi Hee Yu, Nam-Kyung Im, Young Tae Jung, Jinho Lee, Kyung-Soo Chun, In-Seon Lee
Atherosclerosis is a chronic and progressive inflammatory disease. Novel anti-inflammatory therapies may have promise as treatment strategies for cardiovascular risk reduction. Rosemary (Rosemarinus officinalis L.) has been used in folk medicine to treat headaches, epilepsy, poor circulation, and many other ailments. It was found that rosemary could act as a stimulant and mild analgesic and could reduce inflammation. However, the mechanisms underlying the anti-inflammatory and antiatherosclerotic effects of rosemary need more study...
October 2012: Journal of Medicinal Food
https://www.readbyqxmd.com/read/22966842/analysis-of-systemic-endothelin-1-matrix-metalloproteinase-9-macrophage-chemoattractant-protein-1-and-high-sensitivity-c-reactive-protein-in-normal-tension-glaucoma
#14
Na Young Lee, Hae-Young Lopilly Park, Chan Kee Park, Myung Douk Ahn
PURPOSE: To investigate the roles of vascular dysregulation and inflammation in normal-tension glaucoma (NTG), we determined the plasma levels of endothelin-1 (ET-1), matrix metalloproteinase-9 (MMP-9), macrophage chemoattractant protein-1 (MCP-1), and high-sensitivity C-reactive protein (hs-CRP). MATERIALS AND METHODS: Forty-five patients with NTG and age-matched 35 healthy controls were enrolled in this study. Blood samples from all subjects were assayed for ET-1, MMP-9, MCP-1, and hs-CRP concentrations and other systemic factors...
December 2012: Current Eye Research
https://www.readbyqxmd.com/read/22658256/meta060-attenuates-tnf-%C3%AE-activated-inflammation-endothelial-monocyte-interactions-and-matrix-metalloproteinase-9-expression-and-inhibits-nf-%C3%AE%C2%BAb-and-ap-1-in-thp-1-monocytes
#15
Anuradha Desai, Gary Darland, Jeffrey S Bland, Matthew L Tripp, Veera R Konda
BACKGROUND: Cytokine-induced monocyte-endothelial interaction and vascular inflammation play a critical role in atherogenesis. A modified hop extract, META060, was identified as an inhibitor of inflammatory mediators in human rheumatoid arthritis synovial fibroblasts. OBJECTIVE: To determine how META060 may impact the initial stages of atherosclerosis, we investigated the effects of META060 in endothelial and monocyte cell models. METHODS: and results: TNF-α (10 ng/mL)-activated human monocytic THP-1 cells adhered to human aortic endothelial cells (HAECs); pre-treatment of cells with META060 (10 μg/mL) significantly inhibited cell adhesion...
July 2012: Atherosclerosis
https://www.readbyqxmd.com/read/21889487/tanshinone-ii-a-attenuates-and-stabilizes-atherosclerotic-plaques-in-apolipoprotein-e-knockout-mice-fed-a-high-cholesterol-diet
#16
Suowen Xu, Peter J Little, Tian Lan, Yan Huang, Kang Le, Xiaoqian Wu, Xiaoyan Shen, Heqing Huang, Yi Cai, Futian Tang, Hua Wang, Peiqing Liu
Tanshinone II-A (Tan), a bioactive diterpene isolated from Salvia miltiorrhiza Bunge (Danshen), possesses anti-oxidant and anti-inflammatory activities. The present study investigated whether Tan can decrease and stabilize atherosclerotic plaques in Apolipoprotein-E knockout (ApoE(-/-)) mice maintained on a high cholesterol diet (HCD). Six week-old mice challenged with a HCD were randomly assigned to 4 groups: (a) C57BL/6J; (b) ApoE(-/-); (c) ApoE(-/-)+Tan-30 (30 mg/kg/d); (d) ApoE(-/-)+Tan-10 (10mg/kg/d). After 16 weeks of intervention, Tan treated mice showed decreased atherosclerotic lesion size in the aortic sinus and en face aorta...
November 2011: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/21808640/downregulation-of-the-proinflammatory-state-of-circulating-mononuclear-cells-by-short-term-treatment-with-pioglitazone-in-patients-with-type-2-diabetes-mellitus-and-coronary-artery-disease
#17
Andreas Pfützner, Alexander Weise, Elisabeth Pfützner-Riehn, Georg Lübben, Michael Morcos, Efstrathios Karagiannis, Matthias Weber, Thomas Forst
Background. This study was performed to investigate the influence of a short-term treatment with pioglitazone versus placebo on inflammatory activation of mononuclear cells (mRNA expression/protein secretion of inflammatory markers). Methods and Results. Sixty-three patients with well-controlled type 2 diabetes (52 males, 11 females, age (Mean ± SD): 66 ± 7 yrs, disease duration: 6.6 ± 9.6 yrs, HbA1c: 6.7 ± 0.6%) were randomized to additional 45 mg of pioglitazone or placebo to their existing metformin and sulfonylurea therpay for four weeks in a double-blind study design...
2011: PPAR Research
https://www.readbyqxmd.com/read/21771657/non-antibacterial-tetracyclines-modulate-mediators-of-periodontitis-and-atherosclerotic-cardiovascular-disease-a-mechanistic-link-between-local-and-systemic-inflammation
#18
REVIEW
Ying Gu, Hsi-Ming Lee, Timo Sorsa, Aino Salminen, Maria E Ryan, Marvin J Slepian, Lorne M Golub
Periodontitis, one of the most common chronic inflammatory diseases afflicting man, is increasingly being recognized as a risk factor for atherosclerotic cardiovascular disease (ASCVD). Non-antimicrobial tetracyclines are known to have inhibitory effects on inflammatory mediators and effector molecules, including cytokines and matrix metalloproteinases (MMPs), associated with both diseases. In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e...
December 2011: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/21411094/monoclonal-antibodies-targeting-il-1-beta-reduce-biomarkers-of-atherosclerosis-in-vitro-and-inhibit-atherosclerotic-plaque-formation-in-apolipoprotein-e-deficient-mice
#19
Vinay Bhaskar, Johnny Yin, Amer M Mirza, Dan Phan, Sandra Vanegas, Hassan Issafras, Kristen Michelson, John J Hunter, Seema S Kantak
OBJECTIVE: Atherosclerosis is a condition that is increasingly contributing to worldwide mortality through complications such as stroke and myocardial infarction. IL-1β plays multiple direct, local roles in the formation and stability of the atheroma by eliciting the production of additional cytokines and proteolytic enzymes from macrophages, endothelial cells (EC) and smooth muscle cells (SMC). We therefore tested whether an anti-IL-1β antibody, XOMA 052, might inhibit the secretion of pro-atherogenic cytokines from macrophages in vitro and affect a positive outcome in the Apolipoprotein E-deficient mouse (ApoE(-/-)) model of atherosclerosis in vivo...
June 2011: Atherosclerosis
https://www.readbyqxmd.com/read/21193197/eicosapentaenoic-acid-reduces-warfarin-induced-arterial-calcification-in-rats
#20
Saeko Kanai, Kenta Uto, Kazuho Honda, Nobuhisa Hagiwara, Hideaki Oda
BACKGROUND: Eicosapentaenoic acid (EPA), a major n-3 polyunsaturated fatty acid, is reported to have various protective effects for cardiovascular disease. However, few studies have focused on the influence of EPA on vascular calcification. METHODS AND RESULTS: Arterial medial calcification (AMC) was induced by administering warfarin (3 mg/g food) and vitamin K1 (1.5 mg/g food) for 2 weeks in Sprague-Dawley rats (control group), and EPA (1 g/kg/day) was administered for 2 weeks simultaneously with warfarin and vitamin K1 (EPA group) or after initiation of AMC (late EPA group)...
March 2011: Atherosclerosis
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