Julian Kött, Noah Zimmermann, Tim Zell, Alessandra Rünger, Isabel Heidrich, Glenn Geidel, Daniel J Smit, Inga Hansen, Finn Abeck, Dirk Schadendorf, Alexander Eggermont, Susana Puig, Axel Hauschild, Christoffer Gebhardt
PURPOSE OF REVIEW: The role of Sentinel Lymph Node Biopsy (SLNB) is pivotal in the contemporary staging of cutaneous melanoma. In this review, we examine advanced molecular testing platforms like gene expression profiling (GEP) and immunohistochemistry (IHC) as tools for predicting the prognosis of sentinel lymph nodes. We compare these innovative approaches with traditional staging assessments. Additionally, we delve into the shared genetic and protein markers between GEP and IHC tests and their relevance to melanoma biology, exploring their prognostic and predictive characteristics...
March 8, 2024: European Journal of Cancer