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Candida antifungal resistance

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https://www.readbyqxmd.com/read/27931150/in-vitro-synergism-of-a-water-insoluble-fraction-of-uncaria-tomentosa-combined-with-fluconazole-and-terbinafine-against-resistant-non-candida-albicans-isolates
#1
Renata Cougo Moraes, Anderson Ramos Carvalho, Aline Jacobi Dalla Lana, Samuel Kaiser, Bruna Pippi, Alexandre Meneghello Fuentefria, George González Ortega
CONTEXT: Uncaria tomentosa D.C. (Rubiaceae) has several biological activities, including activity against resistant Candida strains. The synergistic interaction with terbinafine or fluconazole can be an important alternative to overcome this resistance. OBJECTIVES: The potential synergy between a water insoluble fraction (WIF) from Uncaria tomentosa bark and the antifungals terbinafine (TRB) and fluconazole (FLZ) against non-Candida albicans resistant strains was investigated...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27931143/synergistic-in-vitro-activity-of-sodium-houttuyfonate-with-fluconazole-against-clinical-candida-albicans-strains-under-planktonic-growing-conditions
#2
Jing Shao, YanYan Cui, MengXiang Zhang, TianMing Wang, DaQiang Wu, ChangZhong Wang
CONTEXT: Fluconazole resistance is an intractable problem of treating Candida albicans, calling for more antifungal agents to enhance the activity of fluconazole. OBJECTIVE: This work investigates the anti-C. albicans activities of sodium houttuyfonate (SH) and/or fluconazole and the associated mechanism. MATERIALS AND METHODS: The minimum inhibitory concentrations (MICs) of SH and fluconazole both ranging from 0.5 to 1024 μg/mL were determined by broth microdilution method in 19 C...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27927053/future-therapies-targeted-towards-eliminating-candida-biofilms-and-associated-infections
#3
H M H N Bandara, V H Matsubara, L P Samaranayake
Candida species are common human commensals and cause either superficial or invasive opportunistic infections. The biofilm form of Candida as opposed to its suspended, planktonic form, is predominantly associated with these infections. Alternative or adjunctive therapies are urgently needed to manage Candida infections as the currently available short arsenal of antifungal drugs has been compromised due to their systemic toxicity, cross-reactivity with other drugs, and above all, by the emergence of drug-resistant Candida species due to irrational drug use...
December 7, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27917162/activity-of-scorpion-venom-derived-antifungal-peptides-against-planktonic-cells-of-candida-spp-and-cryptococcus-neoformans-and-candida-albicans-biofilms
#4
Fernanda Guilhelmelli, Nathália Vilela, Karina S Smidt, Marco A de Oliveira, Alice da Cunha Morales Álvares, Maria C L Rigonatto, Pedro H da Silva Costa, Aldo H Tavares, Sônia M de Freitas, André M Nicola, Octávio L Franco, Lorena da Silveira Derengowski, Elisabeth F Schwartz, Márcia R Mortari, Anamélia L Bocca, Patrícia Albuquerque, Ildinete Silva-Pereira
The incidence of fungal infections has been increasing in the last decades, while the number of available antifungal classes remains the same. The natural and acquired resistance of some fungal species to available therapies, associated with the high toxicity of these drugs on the present scenario and makes an imperative of the search for new, more efficient and less toxic therapeutic choices. Antimicrobial peptides (AMPs) are a potential class of antimicrobial drugs consisting of evolutionarily conserved multifunctional molecules with both microbicidal and immunomodulatory properties being part of the innate immune response of diverse organisms...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27915337/quercetin-assists-fluconazole-to-inhibit-biofilm-formations-of-fluconazole-resistant-candida-albicans-in-in-vitro-and-in-vivo-antifungal-managements-of-vulvovaginal-candidiasis
#5
Mei Gao, Hui Wang, LiJuan Zhu
BACKGROUND: Vulvovaginal candidiasis (VVC) is a common gynecological disease. Candida albicans is believed to be mainly implicated in VVC occurrence, the biofilm of which is one of the virulence factors responsible for resistance to traditional antifungal agents especially to fluconazole (FCZ). Quercetin (QCT) is a dietary flavonoid and has been demonstrated to be antifungal against C. albicans biofilm. METHODS: 17 C. albicans isolates including 15 clinical ones isolated from VVC patients were employed to investigate the effects of QCT and/or FCZ on the inhibition of C...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27915303/candida-species-isolated-from-different-body-sites-and-their-antifungal-susceptibility-pattern-cross-analysis-of-candida-albicans-and-candida-glabrata-biofilms
#6
Valentina Cataldi, Emanuela Di Campli, Paolo Fazii, Tonino Traini, Luigina Cellini, Mara Di Giulio
Candida species are regular commensal in humans, but-especially in immunocompromised patients-they represent opportunistic pathogens giving rise to systemic infection. The aim of the present work was to isolate and characterize for their antifungal profile Candida species from different body sites and to analyze the biofilms produced by C. albicans and C. glabrata isolates. Eighty-one strains of Candida species from 77 patients were identified. Epidemiological study showed that the most isolated species were C...
December 2, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27904062/promising-therapies-for-fungal-infection-based-on-the-study-to-elucidate-mechanisms-to-cope-with-stress-in-candida-species
#7
Kazuyuki Hirai, Tatsuya Inukai, Hironobu Nakayama
In recent years, the incidence of fungal infections has been increasing, particularly among patients with immune systems compromised by human immunodeficiency virus infection, organ transplantation, and/or chemotherapy for cancer. Current therapies for treating systemic fungal infection have limited effectiveness and have created problems of adverse reactions and drug resistance. These issues therefore motivate us to develop novel antifungals. Elucidation of stress response mechanisms and virulence factors in pathogenic fungi is required in developing an effective antifungal strategy...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27902377/comparison-of-susceptibility-patterns-using-commercially-available-susceptibility-testing-methods-performed-on-prevalent-candida-species
#8
David Cretella, Katie E Barber, S Travis King, Kayla R Stover
The rising rates of invasive fungal infections caused by non-albicans Candida and the increasing emergence of antifungal resistance complicate the management of invasive candidiasis. Accurate and timely antifungal susceptibility testing is critical to targeting antifungal therapy. The purpose of this study was to compare commercially available susceptibility testing methods using prospectively collected Candida isolates. Susceptibility testing was performed on 74 Candida isolates collected from July 2014-March 2015 using broth microdilution (BMD) according to the Clinical and Laboratory Standards Institute (CLSI) method, Etest, Vitek2 (YS-05), and Sensititre...
November 1, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27895625/evaluation-of-virulence-factors-in-vitro-resistance-to-osmotic-stress-and-antifungal-susceptibility-of-candida-tropicalis-isolated-from-the-coastal-environment-of-northeast-brazil
#9
Diana L Zuza-Alves, Sayama S T Q de Medeiros, Luanda B F C de Souza, Walicyranison P Silva-Rocha, Elaine C Francisco, Maria C B de Araújo, Reginaldo G Lima-Neto, Rejane P Neves, Analy S de Azevedo Melo, Guilherme M Chaves
Several studies have been developed regarding human health risks associated with the recreational use of beaches contaminated with domestic sewage. These wastes contain various micro-organisms, including Candida tropicalis. In this context, the objective of this study was to characterize C. tropicalis isolates from the sandy beach of Ponta Negra, Natal, Rio Grande do Norte, Brazil, regarding the expression of in vitro virulence factors, adaptation to osmotic stress and susceptibility to antifungal drugs. We analyzed 62 environmental isolates and observed a great variation among them for the various virulence factors evaluated...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27891323/reduced-cx3cl1-secretion-contributes-to-the-susceptibility-of-oral-leukoplakia-associated-fibroblasts-to-candida-albicans
#10
Ran Cheng, Duo Li, Xueke Shi, Qinghong Gao, Changlei Wei, Xiaoyu Li, Yan Li, Hongmei Zhou
Candida leukoplakia (OLK) is a kind of oral leukoplakia combined with chronic candidal infection, which plays an important role in the malignant transformation of OLK. However, little is known about the etiology, including susceptibility of leukoplakia to candidal adhesion, invasion and infection. Some antimicrobial peptides secreted by oral epithelial cells or fibroblasts potentially have antifungal activities against Candida albicans (C. albicans). In this study, we established three co-culture models to simulate different C...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27889440/non-heat-shock-responsive-roles-of-hsf1-in-candida-albicans-are-essential-under-iron-deprivation-and-drug-defense
#11
Remya Nair, Mohd Shariq, Sanjiveeni Dhamgaye, Chinmay K Mukhopadhyay, Shamim Shaikh, Rajendra Prasad
Recently, we have reported that the conditional mutant of the heat shock factor-1 (HSF1) in Candida albicans displays enhanced susceptibility not only towards a plant alkaloid, berberine, but also to diverse antifungal drugs. The present study attempts to identify additional phenotypes highlighting the non-heat shock responsive roles of HSF1 that could be correlated with the enhanced drug susceptibility. We uncover an intricate relationship between cellular iron and HSF1 mediated drug susceptibility of C. albicans...
November 24, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27886119/synthesis-and-antifungal-screening-of-2-1-5-alkyl-arylalkylpyrazin-2-yl-ethylidene-hydrazono-1-3-thiazolidin-4-ones
#12
Veronika Opletalova, Jan Dolezel, Jiri Kunes, Vladimir Buchta, Marcela Vejsova, Marta Kucerova-Chlupacova
Two novel thiosemicarbazones and eight novel 2-{[1-(5-alkyl/arylalkylpyrazin-2-yl)ethylidene]hydrazono}-1,3-thiazolidin-4-ones were prepared and tested against a panel of eight fungal strains-Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E 28, Candida glabrata 20/I, Trichosporon asahii 1188, Aspergillus fumigatus 231, Lichtheimia corymbifera 272, and Trichophyton interdigitale 445. 1,3-Thiazolidin-4-ones exhibited activity against all strains, the most potent derivative was 2-{[1-(5-butylpyrazin-2-yl)ethylidene]hydrazono}e-1,3-thiazolidin-4-one...
November 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27880665/the-current-treatment-landscape-candidiasis
#13
Matteo Bassetti, Maddalena Peghin, Jean-Francois Timsit
The epidemiology of Candida species infection has changed over recent decades, influenced by local hospital-related factors, patient predisposing conditions and type of antifungal agents administered. A shift from Candida albicans as the predominant pathogen towards an increasing prevalence of the species Candida glabrata and Candida parapsilosis amongst critically ill patients has been documented. Changes in Candida species distribution may impact treatment recommendations due to differences in susceptibility to antifungal agents among species...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27870871/functional-genomic-analysis-of-candida-albicans-adherence-reveals-a-key-role-for-the-arp2-3-complex-in-cell-wall-remodelling-and-biofilm-formation
#14
Jason A Lee, Nicole Robbins, Jinglin L Xie, Troy Ketela, Leah E Cowen
Fungal biofilms are complex, structured communities that can form on surfaces such as catheters and other indwelling medical devices. Biofilms are of particular concern with Candida albicans, one of the leading opportunistic fungal pathogens of humans. C. albicans biofilms include yeast and filamentous cells that are surrounded by an extracellular matrix, and they are intrinsically resistant to antifungal drugs such that resolving biofilm infections often requires surgery to remove the contaminated device. C...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27868254/extensive-functional-redundancy-in-the-regulation-of-candida-albicans-drug-resistance-and-morphogenesis-by-lysine-deacetylases-hos2-hda1-rpd3-and-rpd31
#15
Xinliu Li, Nicole Robbins, Teresa R O'Meara, Leah E Cowen
Current treatment efforts for fungal infections are hampered by the limited availability of antifungal drugs and by the emergence of drug resistance. A powerful strategy to enhance the efficacy of antifungal drugs is to inhibit the molecular chaperone Hsp90. Hsp90 governs drug resistance, morphogenesis, and virulence in a leading fungal pathogen of humans, Candida albicans. Our previous work with Saccharomyces cerevisiae established acetylation as a novel mechanism of posttranslational control of Hsp90 function in fungi...
November 21, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27858242/epidemiology-and-reporting-of-candidaemia-in-belgium-a-multi-centre-study
#16
C Trouvé, S Blot, M-P Hayette, S Jonckheere, S Patteet, H Rodriguez-Villalobos, F Symoens, E Van Wijngaerden, K Lagrou
The primary aim of this study was to collect national epidemiological data on candidaemia and to determine the reporting time of species identification and antifungal susceptibility in clinical practice. During a 1-year period (March 2013 until February 2014), every first Candida isolate from each episode of candidaemia was included prospectively from 30 Belgian hospitals. Identification and susceptibility testing were performed according to local procedures and isolates were sent to the National Reference Center for Mycosis...
November 17, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27856170/antifungal-activity-of-acetone-extracts-from-punica-granatum-l-quercus-suber-l-%C3%A2-and-vicia-faba-l
#17
S Akroum
Human and animal mycoses become more frequent and more resistant to traditional treatments. In this work, we tested the in vitro antifungal activity of acetonic extracts of Punica granatum L., Quercus suber L. and Vicia faba L. against seven pathogen fungi and the in vivo antifungal activity against Candida albicans and Trichophyton mentagrophytes. The phytochemical screening was also carried out and showed that the extracts contained mainly proanthocyanidins. Other polyphenols were also present but in low quantity...
November 14, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27855078/echinocandin-resistance-in-candida-spp-isolated-from-liver-transplant-recipients
#18
Gwénolé Prigent, Nawel Aït-Ammar, Eric Levesque, Arnaud Fekkar, Jean-Marc Costa, Sarra El Anbassi, Françoise Foulet, Christophe Duvoux, Jean-Claude Merle, Eric Dannaoui, Françoise Botterel
Liver transplant recipients are at risk of invasive fungal infections, especially candidiasis. Echinocandin is recommended as prophylactic treatment but is increasingly associated with resistance. Our aim was to assess echinocandin drug resistance in Candida spp. isolated from liver transplant recipients treated with this antifungal class. For this, all liver-transplanted patients in a University Hospital (Créteil, France) between January and June of 2013 and 2015 were included. Susceptibilities of Candida isolates to echinocandins were tested by Etest® and EUCAST reference method...
November 14, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27853524/recent-advances-on-candida-albicans-biology-and-virulence
#19
REVIEW
Adnane Sellam, Malcolm Whiteway
Candida albicans is an important human fungal pathogen, in terms of both its clinical significance and its use as an experimental model for scientific investigation. Although this opportunistic pathogen is a natural component of the human flora, it can cause life-threatening infections in immunosuppressed patients. There are currently a limited number of antifungal molecules and drug targets, and increasing resistance to the front-line therapeutics, demonstrating a clear need for new antifungal drugs. Understanding the biology of this pathogen is an important prerequisite for identifying new drug targets for antifungal therapeutics...
2016: F1000Research
https://www.readbyqxmd.com/read/27852744/integrin-cross-talk-regulates-the-human-neutrophil-response-to-fungal-%C3%AE-glucan-in-the-context-of-the-extracellular-matrix-a-prominent-role-for-vla3-in-the-antifungal-response
#20
Courtney M Johnson, Xian M O'Brien, Angel S Byrd, Valentina E Parisi, Alex J Loosely, Wei Li, Hadley Witt, Hafeez M Faridi, Craig T Lefort, Vineet Gupta, Minsoo Kim, Jonathan S Reichner
Candida albicans infection produces elongated hyphae resistant to phagocytic clearance compelling alternative neutrophil effector mechanisms to destroy these physically large microbial structures. Additionally, all tissue-based neutrophilic responses to fungal infections necessitate contact with the extracellular matrix (ECM). Neutrophils undergo a rapid, ECM-dependent mechanism of homotypic aggregation and NETosis in response to C. albicans mediated by the β2 integrin, complement receptor 3 (CR3, CD11b/CD18, αMβ2)...
November 16, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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