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Candida antifungal resistance

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https://www.readbyqxmd.com/read/29143452/engineering-improved-variants-of-the-antifungal-peptide-histatin-5-with-reduced-susceptibility-to-candida-albicans-secreted-aspartic-proteases-and-enhanced-antimicrobial-potency
#1
Svetlana P Ikonomova, Parisa Moghaddam-Taaheri, Mary Ann Jabra-Rizk, Yan Wang, Amy J Karlsson
Candida albicans is an opportunistic fungal pathogen and a commensal organism that commonly colonizes mucosal surfaces, including those inside the human mouth. To help control C. albicans, human saliva contains the antifungal peptide histatin 5 (Hst-5), which has strong antifungal activity against C. albicans. However, the pathogen produces secreted aspartic proteases (Saps) that cleave Hst-5 at lysine residues and eliminate its antifungal properties. We designed variants of Hst-5 with its lysine residues substituted with arginine or leucine to evaluate the effect on proteolysis by Saps...
November 15, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29142078/candida-auris-a-review-of-the-literature
#2
REVIEW
Anna Jeffery-Smith, Surabhi K Taori, Silke Schelenz, Katie Jeffery, Elizabeth M Johnson, Andrew Borman, Rohini Manuel, Colin S Brown
The emerging pathogen Candida auris has been associated with nosocomial outbreaks on five continents. Genetic analysis indicates the simultaneous emergence of separate clades of this organism in different geographical locations. Invasive infection and colonization have been detected predominantly in patients in high-dependency settings and have garnered attention due to variable antifungal resistance profiles and transmission within units instituting a range of infection prevention and control measures. Issues with the identification of C...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29133552/cd101-a-novel-echinocandin-possesses-potent-anti-biofilm-activity-against-early-and-mature-candida-albicans-biofilms
#3
Jyotsna Chandra, Mahmoud A Ghannoum
Currently available echinocandins are generally effective against Candida biofilms, but recent emergence of resistance has underscored the importance of developing new antifungal agents that are effective against biofilms. CD101 is a long-acting, novel echinocandin with distinctive pharmacokinetic properties and improved stability and safety relative to other drugs in the same class. CD101 is currently being evaluated as a once-weekly IV infusion for the treatment of candidemia and invasive candidiasis. In this study, we determined: (1) the effect of CD101 against early and mature phase biofilms formed by C...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29132828/lactoferrin-chitosan-and-melaleuca-alternifolia-natural-products-that-show-promise-in-candidiasis-treatment
#4
REVIEW
Lorena de Oliveira Felipe, Willer Ferreira da Silva Júnior, Katialaine Corrêa de Araújo, Daniela Leite Fabrino
The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance...
November 10, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29127020/does-the-use-of-antifungal-agents-in-agriculture-and-in-food-foster-polyene-resistance-development-a-reason-for-concern
#5
REVIEW
Axel Dalhoff
Environmental fungicides are used in agriculture to reduce fungal spoilage of crop to a minimum and the polyene macrolide natamycin is used as a food preservative. The use of natamycin in yoghurt has recently been authorized in the USA and some other countries. However, resistance development is a serious risk associated with the use of antimicrobials as food additives and environmental fungicides. Cross-resistance between agricultural and medical azoles and amphothericin B, respectively, not being used in agriculture has been demonstrated in clinical and environmental isolates...
November 7, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29126739/discovery-of-simplified-sampangine-derivatives-as-novel-fungal-biofilm-inhibitors
#6
Na Liu, Hua Zhong, Jie Tu, Zhigan Jiang, Yanjuan Jiang, Yan Jiang, Yuanying Jiang, Jian Li, Wannian Zhang, Yan Wang, Chunquan Sheng
Lack of novel antifungal agents and severe drug resistance have led to high incidence and associated mortality of invasive fungal infections. To tackle the challenges, novel antifungal agents with new chemotype, fungicidal activity and anti-resistant potency are highly desirable. On the basis of our previously identified simplified analogue of antifungal natural product sampangine, systemic structure-activity relationships were clarified and two novel derivatives showed promising features as novel antifungal lead compounds...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29111389/antifungal-photosensitive-activity-of-porophyllum-obscurum-spreng-dc-correlation-of-the-chemical-composition-of-the-hexane-extract-with-the-bioactivity
#7
Agustina Postigo, Matías Funes, Elisa Petenatti, Hebe Bottai, Adriana Pacciaroni, Maximiliano Sortino
In this paper, we report Porophyllum obscurum as a source of new photosensitizers with potential use in Photodynamic Therapy as an alternative for oropharyngeal candidiasis treatment. The antifungal photosensitive activity of different extracts from P. obscurum was evaluated by using microdilution and bioautographic assays. The Minimum Fungicidal Concentration for hexanic extract under UV-A irradiation was 0.98μg/mL, but it was inactive in experiments without irradiation. The bioassay-guided fractionation of this extract led to the isolation of four thiophenes responsible for the photosensitive activity: 2,2':5'2″terthiophene, 5-(3-buten-1-ynyl)-2,2'-bithiophene, 5-(4-acetoxy-1-butenyl)-2,2'- bithiophene and 5-(4-hydroxy-1-butenyl)-2,2'- bithiophene, with Minimum Fungicidal Concentrations ranging 0...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29104569/a-linear-19-mer-plant-defensin-derived-peptide-acts-synergistically-with-caspofungin-against-candida-albicans-biofilms
#8
Tanne L Cools, Caroline Struyfs, Jan W Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H S Ramada, Carlos Bloch, Bruno P A Cammue, Karin Thevissen
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co-administered with caspofungin, the preferred antimycotic to treat such infections. In this study, we identified the smallest linear HsAFP1-derived peptide that acts synergistically with caspofungin or anidulafungin against C. albicans as HsLin06_18, a 19-mer peptide derived from the C-terminal part of HsAFP1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29104260/antimicrobial-and-anti-proliferative-effects-of-skin-mucus-derived-from-dasyatis-pastinaca-linnaeus-1758
#9
Virginia Fuochi, Giovanni Li Volti, Giuseppina Camiolo, Francesco Tiralongo, Cesarina Giallongo, Alfio Distefano, Giulio Petronio Petronio, Ignazio Barbagallo, Maria Viola, Pio Maria Furneri, Michelino Di Rosa, Roberto Avola, Daniele Tibullo
Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria...
November 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29103728/short-communication-cold-atmospheric-plasma-inactivation-of-prototheca-zopfii-isolated-from-bovine-milk
#10
E Tyczkowska-Sieron, J Markiewicz, B Grzesiak, H Krukowski, A Glowacka, J Tyczkowski
Mastitis is a serious bovine diseases that can be caused by Prototheca zopfii, yeast-like algae belonging to the family Chlorellaceae. The substantial economic losses and health damage associated with bovine mastitis emphasize the need to develop effective strategies aimed at control of the infection. Unfortunately, P. zopfii is highly resistant to most common antibacterial and antifungal agents, as well as to heat treatment. We report here the first attempt to use cold atmospheric plasma to inactivate this pathogen...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29101485/the-in-vitro-in-vivo-antifungal-activity-and-the-action-mode-of-jelleine-i-against-candida-species
#11
Fengjing Jia, Jiayi Wang, Jinxiu Peng, Ping Zhao, Ziqing Kong, Kairong Wang, Wenjin Yan, Rui Wang
Recently, the mortality of life-threatening fungal infections increased dramatically. However, there are few antifungals existed. Antimicrobial peptides (AMPs) as promising antifungal candidates have attracted much attention. Here, we present a small antimicrobial peptide Jelleine-I that had potent in vitro and in vivo antifungal activity. Negligible hemolytic activity and in vivo toxicity were observed. Selectivity index (SI) of Jelleine-I is at least 4.6 times higher than amphotericin B. Jelleine-I could increase the production of cellular ROS and bind with genome DNA...
November 3, 2017: Amino Acids
https://www.readbyqxmd.com/read/29101061/antimicrobial-efficacy-of-drug-blended-biosynthesized-colloidal-gold-nanoparticles-from-justicia-glauca-against-oral-pathogens-a-nanoantibiotic-approach
#12
Rayappan Emmanuel, Muthupandian Saravanan, Muhammad Ovais, Sethuramasamy Padmavathy, Zabta Khan Shinwari, Periyakaruppan Prakash
Antimicrobial resistance is a challenging task for researchers to develop new strategies. Green synthesis of AuNPs is an eco-friendly approach, which can be utilized in the microbistatic and microbicidal activities. The current study is focused on Justicia glauca (aqueous leaf extract) mediated AuNPs synthesis at room temperature by treating chloroaurate ions, that shows an antagonistic effect with Azithromycin (AZM) and Clarithromycin (CLR) antibiotics against oral pathogenic bacteria and fungi (Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus, Streptococcus mutans, Lactobacillus acidophilus, Escherichia coli, Pseudomonas aeruginosa, Saccharomyces cerevisiae and Candida albicans)...
October 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29095556/antibacterial-and-antifungal-activity-activity-of-pyroligneous-acid-from-wood-of-eucalyptus-urograndis-and-mimosa-tenuiflora
#13
Eduardo de Souza Araújo, Alexandre Santos Pimenta, Francisco M C Feijó, Renato Vinicius Oliveira Castro, Maíra Fasciotti, Thays V C Monteiro, Kássio Michel Gomes de Lima
AIMS: The present work aimed to evaluate the antibacterial and antifungal activity of two types of pyroligneous acid (PA) obtained from slow pyrolysis of wood of Mimosa tenuiflora and of a hybrid of Eucalyptus urophylla x Eucalyptus grandis. METHODS AND RESULTS: Wood wedges were carbonized on a heating rate of 1.25°C/min until 450°C. Pyrolysis smoke was trapped and condensed to yield liquid products. Crude pyrolysis liquids were bi-distilled under 5 mmHg vacuum yielding purified PA...
November 2, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29094611/the-carboxylic-acid-transporters-jen1-and-jen2-affect-the-architecture-and-fluconazole-susceptibility-of-candida-albicans-biofilm-in-the-presence-of-lactate
#14
Rosana Alves, Sandra Mota, Sónia Silva, Célia F Rodrigues, Alistair J P Brown, Mariana Henriques, Margarida Casal, Sandra Paiva
Candida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process...
November 2, 2017: Biofouling
https://www.readbyqxmd.com/read/29091404/incorporation-of-%C3%AE-peptides-enhances-the-antifungal-activity-and-selectivity-of-the-helical-antimicrobial-peptide-aurein-1-2
#15
Myung-Ryul Lee, Namrata Raman, Samuel H Gellman, David M Lynn, Sean P Palecek
Antimicrobial peptides (AMPs) are attractive antifungal drug candidates because they kill microbes via membrane disruption and are thus less likely to provoke development of resistance. Low selectivity for fungal vs. human cells and instability in physiological environments have limited the development of AMPs as therapeutics, but peptidomimetic AMPs can overcome these obstacles and also provide useful insight into AMP structure-function relationships. Here, we describe antifungal peptidomimetic α/β-peptides templated on the natural α-peptidic AMP aurein 1...
November 1, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29081766/an-update-on-candida-tropicalis-based-on-basic-and-clinical-approaches
#16
REVIEW
Diana L Zuza-Alves, Walicyranison P Silva-Rocha, Guilherme M Chaves
Candida tropicalis has emerged as one of the most important Candida species. It has been widely considered the second most virulent Candida species, only preceded by C. albicans. Besides, this species has been recognized as a very strong biofilm producer, surpassing C. albicans in most of the studies. In addition, it produces a wide range of other virulence factors, including: adhesion to buccal epithelial and endothelial cells; the secretion of lytic enzymes, such as proteinases, phospholipases, and hemolysins, bud-to-hyphae transition (also called morphogenesis) and the phenomenon called phenotypic switching...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29080032/anticandidal-activity-of-hetero-dinuclear-copper-ii-mn-ii-schiff-base-and-its-potential-action-of-the-mechanism
#17
Bekir Mustafa Yoğurtçu, Selami Demirci, Ayşegül Doğan, Ayla Burçin Asutay, Fikrettin Şahin
Invasive fungal infections are one of the major challenges especially for immunosuppressed patients since they are drug resistant and pathogen to patients. Therefore, developing new, efficient and nonresistant antifungal agents have been a primary focus of international research. In the current study, a novel Schiff base [hetero-dinuclear copper(II) Mn(II) complex] (SB) derivative was investigated for its anticandidal activity against Candida albicans and possible mechanisms inducing cell death. The results revealed that SB treatment induces apoptotic and necrotic pathways in C...
October 27, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29074435/the-natural-compound-magnolol-affects-growth-biofilm-formation-and-ultrastructure-of-oral-candida-isolates
#18
Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral candidosis has continued to be problematic because of the potential toxicity of antifungals in clinical use, and, above all, development of drug resistance among patients. In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29074432/healthcare-workers-hands-as-a-vehicle-for-the-transmission-of-virulent-strains-of-candida-spp-a-virulence-factor-approach
#19
Karina Mayumi Sakita, Daniella Renata Faria, Eliane Martins da Silva, Flávia Kelly Tobaldini-Valério, Erika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Patricia de Souza Bonfim-Mendonça
BACKGROUND: Although the majority of Candida infections are thought to come from endogenous sources, the healthcare workers' (HCWs) hands are being increasingly reported as vehicles for the transmission of pathogens. The aim of the present study was to evaluate the susceptibility of yeast isolated from the HCWs' hands and ICU (Intensive Care Unit) surfaces to antifungal agents and to determine the virulence potential and the genetic similarity between the same. METHODS: The susceptibility of yeasts from the HCWs' hands (n = 57) and ICU surfaces (n = 98) to conventional antifungals (fluconazole, voriconazole, amphotericin B and micafungin) was evaluated using the broth microdilution assay accordance with CLSI M27-A3...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29062897/synergistic-activity-between-two-antifungal-proteins-the-plant-defensin-nad1-and-the-bovine-pancreatic-trypsin-inhibitor
#20
Mark R Bleackley, Charlotte S Dawson, James A McKenna, Pedro Quimbar, Brigitte M E Hayes, Nicole L van der Weerden, Marilyn A Anderson
Defensins are a large family of small, cationic, cysteine-rich proteins that are part of the defense arsenal that plants use for protection against potentially damaging fungal infections. The plant defensin NaD1 from Nicotiana alata is a potent antifungal protein that inhibits growth and kills a variety of fungal pathogens that affect both plant and animal (human) hosts. Some serine protease inhibitors have also been reported to be antifungal molecules, while others have no inhibitory activity against fungi...
September 2017: MSphere
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