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Candida antifungal resistance

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https://www.readbyqxmd.com/read/28105725/antifungal-peptides-a-potential-new-class-of-antifungals-for-treating-vulvovaginal-candidiasis-caused-by-fluconazole-resistant-candida-albicans
#1
Siew Mei Samantha Ng, Yi Yong Alvin Yap, Jin Wei Darryl Cheong, Fui Mee Ng, Qiu Ying Lau, Timothy Barkham, Jeanette Woon Pei Teo, Jeffrey Hill, Cheng San Brian Chia
Vulvovaginal candidiasis/candidosis is a common fungal infection afflicting approximately 75% of women globally caused primarily by the yeast Candida albicans. Fluconazole is widely regarded as the antifungal drug of choice since its introduction in 1990 due to its high oral bioavailability, convenient dosing regimen and favourable safety profile. However, its widespread use has led to the emergence of fluconazole-resistant C. albicans, posing a universal clinical concern. Coupled to the dearth of new antifungal drugs entering the market, it is imperative to introduce new drug classes to counter this threat...
January 19, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28101934/detection-of-neonatal-unit-clusters-of-candida-parapsilosis-fungaemia-by-microsatellite-genotyping-results-from-laboratory-based-sentinel-surveillance-south-africa-2009-2010
#2
Rindidzani E Magobo, Serisha D Naicker, Jeannette Wadula, Maphoshane Nchabeleng, Yacoob Coovadia, Anwar Hoosen, Shawn R Lockhart, Nelesh P Govender
Neonatal candidaemia is a common, deadly and costly hospital-associated disease. To determine the genetic diversity of Candida parapsilosis causing fungaemia in South African neonatal intensive care units (NICUs). From February 2009 through to August 2010, cases of candidaemia were reported through laboratory-based surveillance. C. parapsilosis isolates from neonatal cases were submitted for identification by internal transcribed spacer (ITS) region sequencing, antifungal susceptibility testing and microsatellite genotyping...
January 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28098553/biofilm-forming-capability-of-highly-virulent-multidrug-resistant-candida-auris
#3
Leighann Sherry, Gordon Ramage, Ryan Kean, Andrew Borman, Elizabeth M Johnson, Malcolm D Richardson, Riina Rautemaa-Richardson
The emerging multidrug-resistant yeast pathogen Candida auris has attracted considerable attention as a source of healthcare-associated infections. We report that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensitive to the disinfectant chlorhexidine in vitro.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28094180/antifungal-activity-of-substituted-aurones
#4
Caleb L Sutton, Zachary E Taylor, Mary B Farone, Scott T Handy
Novel antifungals are in high demand as there is a growing resistance to antifungals currently in use. In particular, opportunistic fungal infections caused by Candida spp. are on the rise with infections by this genus accounting for the most severe fungal infections following chemotherapy, implantation procedures, and in patients with HIV/AIDS. A series of simple aurone analogs were synthesized and screened for antifungal activity versus Candida spp. Several compounds displayed activity at 100μM, with two having IC50 values below 20μM for three species of Candida...
January 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28090278/isolation-and-identification-of-phyllospheric-bacteria-possessing-antimicrobial-activity-from-astragalus-obtusifolius-prosopis-juliflora-xanthium-strumarium-and-hippocrepis-unisiliqousa
#5
Zohreh Mazinani, Marzieh Zamani, Soroush Sardari
BACKGROUND: The widespread utilization of antimicrobial compounds has caused emergence of resistant microorganisms in the world. Hence, the research to probe the products with antimicrobial features has led to finding natural habitats and discovering new pharmaceutical products. METHODS: In this study, an attempt was made to explore the niche of novel habitat to isolate pyllospheric bacteria from the above ground parts (stems and leaves) of Astragalus obtusifolius, Prosopis juliflora, Xanthium strumarium, and Hippocrepis unisiliqousa to evaluate their antimicrobial features...
January 2017: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/28071858/synthesis-and-biological-evaluation-of-novel-2-aminonicotinamide-derivatives-as-antifungal-agents
#6
Tingjunhong Ni, Ran Li, Fei Xie, Jing Zhao, Xin Huang, Maomao An, Chengxu Zang, Zhan Cai, Dazhi Zhang, Yuanying Jiang
Based on the structures of the reported compounds G884 [N-(3-(pentan-2-yloxy)phenyl)nicotinamide], E1210 [3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine], and 10 b [2-amino-N-((5-(3-fluorophenoxy)thiophen-2-yl)methyl)nicotinamide], which inhibit the biosynthesis of glycosylphosphatidylinositol (GPI)-anchored proteins in fungi, a series of novel 2-aminonicotinamide derivatives were designed, synthesized, and evaluated for in vitro antifungal activity. Most of these compounds were found to exhibit potent in vitro antifungal activity against Candida albicans, with MIC80 values ranging from 0...
January 10, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28065893/pan-azole-resistant-candida-tropicalis-carrying-homozygous-erg11-mutations-at-position-k143r-a-new-emerging-superbug
#7
Mariana I D S Xisto, Rita D F Caramalho, Débora A S Rocha, Antonio Ferreira-Pereira, Bettina Sartori, Eliana Barreto-Bergter, Maria L Junqueira, Cornelia Lass-Flörl, Michaela Lackner
OBJECTIVES: Candidaemia is a public health problem mainly in hospitalized individuals worldwide. In Brazil, Candida albicans is the most prevalent species that causes candidaemia, followed by Candida tropicalis and Candida parapsilosis Few data on the abundance of antifungal resistance are available for Latin America. METHODS: We analysed the frequency of azole and echinocandin resistance in Candida isolates (n = 75) collected between 2012 and 2014 at the University Hospital of Federal University of Juiz de Fora (Brazil)...
January 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28052349/chemical-composition-and-antifungal-activity-of-carica-papaya-linn-seeds-essential-oil-against-candida-spp
#8
Xiaowen He, Yinzheng Ma, Guohui Yi, Jinyan Wu, Limin Zhou, Hong Guo
In recent years, the incidence of clinical yeast infections has increased dramatically. Due to the extensive use of broad-spectrum antifungal agents, there has been a notable increase in drug resistance among infections yeast species. As one of the most popular natural antimicrobial agents, essential oils (EOs) have attracted a lot of attention from the scientific community. The aim of this study was to analyze the chemical composition and examine the antifungal activity of the EO extracted from the seeds of Carica papaya Linn...
January 4, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28050365/caspofungin-mic-distribution-amongst-commonly-isolated-candida-species-in-a-tertiary-care-centre-an-indian-experience
#9
Shashir Wanjare, Rajarshi Gupta, Preeti Mehta
INTRODUCTION: Emergence of Candida species resistant to Amphotericin B and triazole has led to use of echinocandins, mostly caspofungin in the management of invasive candidiasis. There are some published reports of caspofungin resistance in Candida species yet no studies on caspofungin susceptibility pattern of Candida species exist in Indian setup. AIM: To carry out the antifungal susceptibility of Candida isolates against caspofungin. MATERIALS AND METHODS: In a retrospective study at a tertiary care teaching hospital, 60 preserved Candida isolates from inpatients of invasive candidiasis obtained over a period of 6 months from January 2015 to June 2015 were subjected to antifungal susceptibility to caspofungin and the Minimum Inhibitory Concentrations (MICs) of Candida species to caspofungin were determined by Epsilometer test (E-test)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28040409/antifungal-effects-of-phytocompounds-on-candida-species-alone-and-in-combination-with-fluconazole
#10
REVIEW
Mengjiao Lu, Tao Li, Jianjian Wan, Xiuyun Li, Lei Yuan, Shujuan Sun
Invasive fungal infections caused by Candida spp. remain the most predominant nosocomial fungal infections. Owing to the increased use of antifungal agents, resistance of Candida spp. to antimycotics has emerged frequently, especially to fluconazole (FLC). To cope with this issue, new efforts have been dedicated to discovering novel antimycotics or new agents that can enhance the susceptibility of Candida spp. to existing antimycotics. The secondary metabolites of plants represent a large library of compounds that are important sources for new drugs or compounds suitable for further modification...
December 15, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28029734/investigation-of-the-first-seven-reported-cases-of-candida-auris-a-globally-emerging-invasive-multidrug-resistant-fungus-united-states-may-2013-august-2016
#11
EDITORIAL
S Vallabhaneni, A Kallen, S Tsay, N Chow, R Welsh, J Kerins, S K Kemble, M Pacilli, S R Black, E Landon, J Ridgway, T N Palmore, A Zelzany, E H Adams, M Quinn, S Chaturvedi, J Greenko, R Fernandez, K Southwick, E Y Furuya, D P Calfee, C Hamula, G Patel, P Barrett, P Lafaro, E L Berkow, H Moulton-Meissner, J Noble-Wang, R P Fagan, B R Jackson, S R Lockhart, A P Litvintseva, T M Chiller
November 11, 2016/65(44);1234-1237. What is already known about this topic? Candida auris is an emerging pathogenic fungus that has been reported from at least a dozen countries on four continents during 2009-2015. The organism is difficult to identify using traditional biochemical methods, some isolates have been found to be resistant to all three major classes of antifungal medications, and C. auris has caused health care-associated outbreaks. What is added by this report? This is the first description of C...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28025839/biological-and-structural-effects-of-the-conjugation-of-an-antimicrobial-decapeptide-with-saturated-unsaturated-methoxylated-and-branched-fatty-acids
#12
María Verónica Húmpola, María Carolina Rey, Nestor M Carballeira, Arturo Carlos Simonetta, Georgina Guadalupe Tonarelli
The increasing bacterial resistance against conventional antibiotics has led to the search for new antimicrobial drugs with different modes of action. Cationic antimicrobial peptides (AMPs) and lipopeptides are promising candidates to treat infections because they act on bacterial membranes causing rapid destruction of sensitive bacteria. In this study, a decapeptide named A2 (IKQVKKLFKK) was conjugated at the N-terminus with saturated, unsaturated, methoxylated and methyl -branched fatty acids of different chain lengths (C8 - C20), the antimicrobial and structural properties of the lipopeptides being then investigated...
December 26, 2016: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28018323/genetic-drivers-of-multidrug-resistance-in-candida-glabrata
#13
Kelley R Healey, Cristina Jimenez Ortigosa, Erika Shor, David S Perlin
Both the incidence of invasive fungal infections and rates of multidrug resistance associated with fungal pathogen Candida glabrata have increased in recent years. In this perspective, we will discuss the mechanisms underlying the capacity of C. glabrata to rapidly develop resistance to multiple drug classes, including triazoles and echinocandins. We will focus on the extensive genetic diversity among clinical isolates of C. glabrata, which likely enables this yeast to survive multiple stressors, such as immune pressure and antifungal exposure...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28018316/leveraging-the-attributes-of-mucor-hiemalis-derived-silver-nanoparticles-for-a-synergistic-broad-spectrum-antimicrobial-platform
#14
Nafe Aziz, Rishikesh Pandey, Ishan Barman, Ram Prasad
Driven by the need to engineer robust surface coatings for medical devices to prevent infection and sepsis, incorporation of nanoparticles has surfaced as a promising avenue to enhance non-fouling efficacy. Microbial synthesis of such nanoscale metallic structures is of substantive interest as this can offer an eco-friendly, cost-effective, and sustainable route for further development. Here we present a Mucor hiemalis-derived fungal route for synthesis of silver nanoparticles, which display significant antimicrobial properties when tested against six pathological bacterial strains (Klebsiella pneumoniae, Pseudomonas brassicacearum, Aeromonas hydrophila, Escherichia coli, Bacillus cereus, and Staphylococcus aureus) and three pathological fungal strains (Candida albicans, Fusarium oxysporum, and Aspergillus flavus)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28011958/cationic-porphyrin-mediated-photodynamic-inactivation-of-candida-biofilms-and-the-effect-of-miconazole
#15
A Davies, S Gebremedhin, M Yee, R J Padilla, N Duzgunes, K Konopka, B Dorocka-Bobkowska
The formation of biofilms by Candida and the increasing resistance of Candida species to antifungals contribute to the high recurrence rates of denture stomatitis. This increase has stimulated an interest in antimicrobial photodynamic therapy (aPDT) as an alternative treatment. We examined the photoactivity of the porphyrin-based photosensitizer, TMP-1363, against biofilms of C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, and the effect of the combined use of miconazole and aPDT. Biofilms of three American Type Culture Collection (ATCC) strains and four clinical isolates developed on poly(methyl methacrylate) (PMMA) disks, were incubated with miconazole, followed by treatment with TMP-1363 for 30 min at 37°C...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28006028/synergistic-effects-and-mechanisms-of-budesonide-in-combination-with-fluconazole-against-resistant-candida-albicans
#16
Xiuyun Li, Cuixiang Yu, Xin Huang, Shujuan Sun
Candida albicans is an important opportunistic pathogen, causing both superficial mucosal infections and life-threatening systemic diseases in the clinic. The emergence of drug resistance in Candida albicans has become a noteworthy phenomenon due to the extensive use of antifungal agents and the development of biofilms. This study showed that budesonide potentiates the antifungal effect of fluconazole against fluconazole-resistant Candida albicans strains both in vitro and in vivo. In addition, our results demonstrated, for the first time, that the combination of fluconazole and budesonide can reverse the resistance of Candida albicans by inhibiting the function of drug transporters, reducing the formation of biofilms, promoting apoptosis and inhibiting the activity of extracellular phospholipases...
2016: PloS One
https://www.readbyqxmd.com/read/28004519/antimicrobial-assay-and-genetic-screening-of-selected-freshwater-cyanobacteria-and-identification-of-a-biomolecule-dihydro-2h-pyran-2-one-derivative
#17
A Srivastava, V K Singh, S Patnaik, J Tripathi, P Singh, G Nath, R K Asthana
AIMS: Explorations of freshwater cyanobacteria as antimicrobial (bacteria, fungi and MRSA strains) drug resource using bioassay, NRPS (non-ribosomal polypeptide synthetase) and PKS (polyketide synthase) genes, as well as in silico approach. METHODS AND RESULTS: We have bioassayed the extracts of Phormidium CCC727, Geitlerinema CCC728, Arthrospira CCC729, Leptolyngbya CCC732, Phormidium CCC730, Phormidium CCC731 against six pathogenic bacteria Gram (+ve): Staphylococcus aureus including seven clinical methicillin-resistant S...
December 22, 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27999568/potential-antifungal-targets-against-a-candida-biofilm-based-on-an-enzyme-in-the-arachidonic-acid-cascade-a-review
#18
REVIEW
Xinning Liu, Decai Wang, Cuixiang Yu, Tao Li, Jianqiao Liu, Shujuan Sun
Candida is an important opportunistic fungal pathogen, especially in biofilm associated infections. The formation of a Candida biofilm can decrease Candida sensitivity to antifungal drugs and cause drug resistance. Although many effective antifungal drugs are available, their applications are limited due to their high toxicity and cost. Seeking new antifungal agents that are effective against biofilm-associated infection is an urgent need. Many research efforts are underway, and some progress has been made in this field...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27999566/isolation-screening-and-identification-of-novel-isolates-of-actinomycetes-from-india-for-antimicrobial-applications
#19
Vineeta Singh, Shafiul Haque, Harshita Singh, Jyoti Verma, Kumari Vibha, Rajbir Singh, Arshad Jawed, C K M Tripathi
The search for novel bioactive compounds from the natural environment has rapidly been gaining momentum with the increase in multi-drug resistant (MDR) pathogens. In the present study, the antimicrobial potential of novel actinomycetes has been evaluated by initial screening of six soil samples. Primary and secondary screening was performed against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Candida albicans, Candida tropicalis, Trichophyton rubrum, and other MDR bacterial and fungal test strains, thirteen active isolates were selected for further study...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27998758/the-synthesis-and-antifungal-activity-of-20s-3%C3%AE-acetoxy-5%C3%AE-pregnane-20-16%C3%AE-carbolactone-against-fluconazole-resistant-candida-cells
#20
Izabella Jastrzebska, Katarzyna Niemirowicz, Wioleta I Brzozowska, Robert Bucki
An efficient procedure for the synthesis of (20S)-3β-acetoxy-5α-pregnane-20,16β-carbolactone is described. Bactericidal and fungicidal activity of the lactone against different bacteria such as MSSA, MRSA, E. coli ESBL, P. aeruginosa and clinical isolates of Candida spp., in planktonic and biofilm growth stage were assessed. Additionally, the affinity of this new compound to microbial plasma membrane and hemoglobin release from human red blood cells were determined using fluorometric and colorimetric assay, respectively...
December 18, 2016: Steroids
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