Alberto Insuasty, Juan Ramírez, Marcela Raimondi, Carlos Echeverry, Jairo Quiroga, Rodrigo Abonia, Manuel Nogueras, Justo Cobo, María Victoria Rodríguez, Susana A Zacchino, Braulio Insuasty
New hetaryl- and alkylidenerhodanine derivatives 3a-d, 3e, and 4a-d were prepared from heterocyclic aldehydes 1a-d or acetaldehyde 1e. The treatment of several rhodanine derivatives 3a-d and 3e with piperidine or morpholine in THF under reflux, afforded (Z)-5-(hetarylmethylidene)-2-(piperidin-1-yl)thiazol-4(5H)-ones and 2-morpholinothiazol-4(5H)-ones 5a-d, 6a-d, and (Z)-5-ethylidene-2-morpholinothiazol-4(5H)-one (5e), respectively, in good yields. Structures of all compounds were determined by IR, 1D and 2D NMR and mass spectrometry...
2013: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry