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https://www.readbyqxmd.com/read/29332969/c12h12-interconversions-two-non-pyrolytic-syntheses-of-tricyclo-5-3-2-04-8-dodeca-2-5-9-11-tetraene
#1
Ihsan Erden, Cindy J Gleason
Herein, we describe two independent and non-pyrolytic syntheses of an important C12H12 hydrocarbon which had been prepared previously by gas phase thermolysis of compound 6. The first method is based on an unusual dipolar cycloaddition of dichloroketene onto bullvalene. After reductive dechlorination, a Shapiro-Heath reaction of the tosylhydrazone gave the title compound. Alternatively, compound 13 is also obtained from its isomer 6 by a Ag+ catalyzed reaction.
January 17, 2018: Tetrahedron Letters
https://www.readbyqxmd.com/read/29329189/beta-cell-death-by-cell-free-dna-and-outcome-after-clinical-islet-transplantation
#2
Boris L Gala-Lopez, Daniel Neiman, Tatsuya Kin, Doug O'Gorman, Andrew R Pepper, Andrew J Malcolm, Sheina Pianzin, Peter A Senior, Patricia Campbell, Benjamin Glaser, Yuval Dor, Ruth Shemer, A M James Shapiro
BACKGROUND: Optimizing engraftment and early survival after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures to assess beta cell death. Circulating cell free DNA (cfDNA) derived from beta cells has been identified as a novel biomarker to detect cell loss, and was recently validated in new-onset type 1 diabetes and in islet transplant patients. METHODS: Herein we report beta cell cfDNA measurements after allotransplantation in 37 subjects and the correlation with clinical outcomes...
January 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29329100/a-web-based-system-for-bayesian-benchmark-dose-estimation
#3
Kan Shao, Andrew J Shapiro
BACKGROUND: Benchmark dose (BMD) modeling is an important step in human health risk assessment and is used as the default approach to identify the point of departure for risk assessment. A probabilistic framework for dose-response assessment has been proposed and advocated by various institutions and organizations; therefore, a reliable tool is needed to provide distributional estimates for BMD and other important quantities in dose-response assessment. OBJECTIVES: We developed an online system for Bayesian BMD (BBMD) estimation and compared results from this software with U...
January 11, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29326212/complete-genome-sequence-of-thermoanaerobacterium-sp-strain-rbiitd-a-butyrate-and-butanol-producing-thermophile
#4
Ranjita Biswas, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, T B K Reddy, Chris Daum, Nicole Shapiro, Natalia Ivanova, Nikos C Kyrpides, Tanja Woyke, Adam M Guss
Thermoanaerobacterium sp. strain RBIITD was isolated from contaminated rich growth medium at 55°C in an anaerobic chamber. It primarily produces butyrate as a fermentation product from plant biomass-derived sugars. The whole-genome sequence of the strain is 3.4 Mbp, with 3,444 genes and 32.48% GC content.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325988/arboriscoccus-pini-gen-nov-sp-nov-an-endophyte-from-a-pine-tree-of-the-class-alphaproteobacteria-emended-description-of-geminicoccus-roseus-and-proposal-of-geminicoccaceae-fam-nov
#5
Diogo N Proença, William B Whitman, Neha Varghese, Nicole Shapiro, Tanja Woyke, Nikos C Kyrpides, Paula V Morais
Bacterial strain B29T1T was isolated from the endophytic microbial community of a Pinus pinaster tree trunk and characterized. Strain B29T1T stained Gram-negative and formed diplococci that grew optimally at 26-30°C and at pH 6.0-7.0. The G+C content of the DNA was 61.6mol%. The respiratory quinone was ubiquinone 10 (UK-10), and the major fatty acids were C16:0, cyclo-C19:0ω8c and C18:0 12-methyl, representing 64% of the total fatty acids. Phylogenetic analyses based on the 16S rRNA gene sequences placed strain B29T1T within the order Rhodospirillales in a distinct lineage that also included the genus Geminicoccus...
December 22, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29324729/vital-signs-trends-and-disparities-in-infant-safe-sleep-practices-united-states-2009-2015
#6
Jennifer M Bombard, Katherine Kortsmit, Lee Warner, Carrie K Shapiro-Mendoza, Shanna Cox, Charlan D Kroelinger, Sharyn E Parks, Deborah L Dee, Denise V D'Angelo, Ruben A Smith, Kim Burley, Brian Morrow, Christine K Olson, Holly B Shulman, Leslie Harrison, Carri Cottengim, Wanda D Barfield
There have been dramatic improvements in reducing infant sleep-related deaths since the 1990s, when recommendations were introduced to place infants on their backs for sleep. However, there are still approximately 3,500 sleep-related deaths among infants each year in the United States, including those from sudden infant death syndrome, accidental suffocation and strangulation in bed, and unknown causes. Unsafe sleep practices, including placing infants in a nonsupine (on side or on stomach) sleep position, bed sharing, and using soft bedding in the sleep environment (e...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29323422/community-interest-and-feasibility-of-using-a-novel-smartphone-based-formaldehyde-exposure-detection-technology
#7
Jessica Castner, Gretchen E Gehrke, Nicholas Shapiro, Karen C Dannemiller
OBJECTIVE: This study is the first community engagement phase of a project to develop a residential formaldehyde detection system. The objectives were to conduct a feasibility assessment for device use, and identify factors associated with concerns about environmental exposure and community interest in this device. DESIGN AND SAMPLE: A cross-sectional, internet-based survey employing community-based participatory research principles was utilized. 147 individuals participated from a focused Waycross, Georgia (58...
January 11, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29323202/genome-based-classification-of-micromonosporae-with-a-focus-on-their-biotechnological-and-ecological-potential
#8
Lorena Carro, Imen Nouioui, Vartul Sangal, Jan P Meier-Kolthoff, Martha E Trujillo, Maria Del Carmen Montero-Calasanz, Nevzat Sahin, Darren Lee Smith, Kristi E Kim, Paul Peluso, Shweta Deshpande, Tanja Woyke, Nicole Shapiro, Nikos C Kyrpides, Hans-Peter Klenk, Markus Göker, Michael Goodfellow
There is a need to clarify relationships within the actinobacterial genus Micromonospora, the type genus of the family Micromonosporaceae, given its biotechnological and ecological importance. Here, draft genomes of 40 Micromonospora type strains and two non-type strains are made available through the Genomic Encyclopedia of Bacteria and Archaea project and used to generate a phylogenomic tree which showed they could be assigned to well supported phyletic lines that were not evident in corresponding trees based on single and concatenated sequences of conserved genes...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323175/functional-antibody-response-against-v1v2-and-v3-of-hiv-gp120-in-the-vax003-and-vax004-vaccine-trials
#9
Preetha Balasubramanian, Constance Williams, Mariya B Shapiro, Faruk Sinangil, Keith Higgins, Arthur Nádas, Maxim Totrov, Xiang-Peng Kong, Andrew J Fiore-Gartland, Nancy L Haigwood, Susan Zolla-Pazner, Catarina E Hioe
Immunization with HIV AIDSVAX gp120 vaccines in the phase III VAX003 and VAX004 trials did not confer protection. To understand the shortcomings in antibody (Ab) responses induced by these vaccines, we evaluated the kinetics of Ab responses to the V1V2 and V3 regions of gp120 and the induction of Ab-mediated antiviral functions during the course of 7 vaccinations over a 30.5-month period. Plasma samples from VAX003 and VAX004 vaccinees and placebo recipients were measured for ELISA-binding Abs and for virus neutralization, Ab-dependent cellular phagocytosis (ADCP), and Ab-dependent cellular cytotoxicity (ADCC)...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321155/plasminogen-replacement-therapy-for-the-treatment-of-children-and-adults-with-congenital-plasminogen-deficiency
#10
Amy D Shapiro, Charles Nakar, Joseph M Parker, Gary R Albert, John E Moran, Karen Thibaudeau, Neelam Thukral, Brandon M Hardesty, Pierre Laurin, Per Morten Sandset
Congenital plasminogen deficiency is caused by mutation(s) in PLG, the gene coding for production of the zymogen plasminogen, and is an ultra-rare disorder associated with abnormal accumulation or growth of fibrin-rich pseudomembranous lesions on mucous membranes, such as the conjunctiva, gingiva, and linings of the airways and genitourinary tract. Left untreated, these lesions may impair normal tissue and organ function, and impact quality of life. Plasminogen replacement therapy should provide an effective treatment of the clinical manifestations of congenital plasminogen deficiency...
January 10, 2018: Blood
https://www.readbyqxmd.com/read/29318961/targeting-na-k-atpase-signaling-a-new-approach-to-control-oxidative-stress
#11
Jiang Liu, Megan N Lilly, Joseph I Shapiro
Renal and cardiac function are greatly affected by chronic oxidative stress which can cause many pathophysiological states. The Na/K-ATPase is well-described as an ion pumping enzyme involved in maintaining cellular ion homeostasis; however, in the past two decades, extensive research has been done to understand the signaling function of the Na/K-ATPase and determine its role in physiological and pathophysiological states. Our lab has shown that the Na/K-ATPase signaling cascade can function as an amplifier of reactive oxygen species (ROS) which can be initiated by cardiotonic steroids or increases in ROS...
January 9, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29317627/mapping-the-microscale-origins-of-magnetic-resonance-image-contrast-with-subcellular-diamond-magnetometry
#12
Hunter C Davis, Pradeep Ramesh, Aadyot Bhatnagar, Audrey Lee-Gosselin, John F Barry, David R Glenn, Ronald L Walsworth, Mikhail G Shapiro
Magnetic resonance imaging (MRI) is a widely used biomedical imaging modality that derives much of its contrast from microscale magnetic field patterns in tissues. However, the connection between these patterns and the appearance of macroscale MR images has not been the subject of direct experimental study due to a lack of methods to map microscopic fields in biological samples. Here, we optically probe magnetic fields in mammalian cells and tissues with submicron resolution and nanotesla sensitivity using nitrogen-vacancy diamond magnetometry, and combine these measurements with simulations of nuclear spin precession to predict the corresponding MRI contrast...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29310983/applying-advanced-analytics-to-guide-emergency-department-operational-decisions-a-proof-of-concept-study-examining-the-effects-of-boarding
#13
R Andrew Taylor, Arjun Venkatesh, Vivek Parwani, Sharon Chekijian, Marc Shapiro, Andrew Oh, David Harriman, Asim Tarabar, Andrew Ulrich
BACKGROUND: Emergency Department (ED) leaders are increasingly confronted with large amounts of data with the potential to inform and guide operational decisions. Routine use of advanced analytic methods may provide additional insights. OBJECTIVES: To examine the practical application of available advanced analytic methods to guide operational decision making around patient boarding. METHODS: Retrospective analysis of the effect of boarding on ED operational metrics from a single site between 1/2015 and 1/2017...
January 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29306353/vibrio-cholerae-genomic-diversity-within-and-between-patients
#14
Inès Levade, Yves Terrat, Jean-Baptiste Leducq, Ana A Weil, Leslie M Mayo-Smith, Fahima Chowdhury, Ashraful I Khan, Jacques Boncy, Josiane Buteau, Louise C Ivers, Edward T Ryan, Richelle C Charles, Stephen B Calderwood, Firdausi Qadri, Jason B Harris, Regina C LaRocque, B Jesse Shapiro
Cholera is a severe, water-borne diarrhoeal disease caused by toxin-producing strains of the bacterium Vibrio cholerae. Comparative genomics has revealed 'waves' of cholera transmission and evolution, in which clones are successively replaced over decades and centuries. However, the extent of V. cholerae genetic diversity within an epidemic or even within an individual patient is poorly understood. Here, we characterized V. cholerae genomic diversity at a micro-epidemiological level within and between individual patients from Bangladesh and Haiti...
December 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29305945/urosymphyseal-fistulas-resulting-from-endoscopic-treatment-of-radiation-induced-posterior-urethral-strictures
#15
Daniel D Shapiro, David C Goodspeed, Wade Bushman
Objective To describe the inciting events leading to urosymphyseal fistulas (UF) and pubic osteomyelitis (PO) in patients who had radiation induced urethral strictures. Materials and Methods We retrospectively reviewed patients who underwent simultaneous pubic debridement, simple cystectomy and urinary diversion for refractory UF and PO from 2014-2016. We investigated inciting events leading to UF as well as patient presenting symptoms, diagnosis, management, and outcomes. Results Five patients were identified over a two-year period...
January 3, 2018: Urology
https://www.readbyqxmd.com/read/29304507/perturbation-exercises-during-treadmill-walking-improve-pelvic-and-trunk-motion-in-older-adults-a-randomized-control-trial
#16
Yoav Gimmon, Raziel Riemer, Ilan Kurz, Amir Shapiro, Ronen Debbi, Itshak Melzer
BACKGROUND: Most falls among older adults occur while walking. Pelvic and trunk motions are required to maintain stability during walking. We aimed to explore whether training that incorporates unexpected loss of balance during walking that evokes balance recovery reactions will improve pelvic, thorax, and trunk kinematics at different walking speeds. METHODS: Fifty-three community-dwelling older adults (age 80.1 ± 5.6 years) were randomly allocated to an intervention group (n = 27) or a control group (n = 26)...
December 27, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29303034/the-effects-of-restrictive-housing-on-the-psychological-functioning-of-inmates
#17
J Hunter Astor, Thomas J Fagan, David Shapiro
The use of restrictive housing as a correctional management tool has received much attention in recent years, especially as it impacts psychological functioning. While there is considerable literature advocating for the reduced use of restrictive housing, much of it is based on opinions, interview data, and testimonials. This article reviews only the empirical evidence regarding the effects of restrictive housing on psychological functioning in actual correctional settings. Results of this review indicate that only a limited number of empirical studies examine the effects of restrictive housing on mental functioning in correctional settings...
January 1, 2018: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/29302281/color-stability-of-cad-cam-zirconia-ceramics-following-exposure-to-acidic-and-staining-drinks
#18
Marco Colombo, Marco Cavallo, Matteo Miegge, Alberto Dagna, Riccardo Beltrami, Marco Chiesa, Claudio Poggio
Background: The aim of this in vitro study was to evaluate the color stability of CAD/CAM Zirconia ceramics following exposure to acidic drink (Coca Cola) and after exposure to staining solution (coffee). Material and Methods: All the samples were immersed in different staining solutions over a 28-day test period. A colorimetric evaluation according to the CIE L*a*b* system was performed by a blind trained operator at 7, 14, 21, 28 days of the staining process. Shapiro Wilk test and Kruskal-Wallis ANOVA were applied to assess significant differences among restorative materials...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29300010/acoustic-reporter-genes-for-noninvasive-imaging-of-microorganisms-in-mammalian-hosts
#19
Raymond W Bourdeau, Audrey Lee-Gosselin, Anupama Lakshmanan, Arash Farhadi, Sripriya Ravindra Kumar, Suchita P Nety, Mikhail G Shapiro
The mammalian microbiome has many important roles in health and disease, and genetic engineering is enabling the development of microbial therapeutics and diagnostics. A key determinant of the activity of both natural and engineered microorganisms in vivo is their location within the host organism. However, existing methods for imaging cellular location and function, primarily based on optical reporter genes, have limited deep tissue performance owing to light scattering or require radioactive tracers. Here we introduce acoustic reporter genes, which are genetic constructs that allow bacterial gene expression to be visualized in vivo using ultrasound, a widely available inexpensive technique with deep tissue penetration and high spatial resolution...
January 3, 2018: Nature
https://www.readbyqxmd.com/read/29298418/neuronal-pas-domain-protein-4-suppression-of-oxygen-sensing-optimizes-metabolism-during-excitation-of-neuroendocrine-cells
#20
Paul V Sabatini, Thilo Speckmann, Cuilan Nian, Maria M Glavas, Chi Kin Wong, Ji Soo Yoon, Tatsuya Kin, A M James Shapiro, William T Gibson, C Bruce Verchere, Francis C Lynn
Depolarization of neuroendocrine cells results in calcium influx, which induces vesicle exocytosis and alters gene expression. These processes, along with the restoration of resting membrane potential, are energy intensive. We hypothesized that cellular mechanisms exist to maximize energy production during excitation. Here, we demonstrate that NPAS4, an immediate early basic helix-loop-helix (bHLH)-PAS transcription factor, acts to maximize energy production by suppressing hypoxia-inducible factor 1α (HIF1α)...
January 2, 2018: Cell Reports
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