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Ethyl glucuronide

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https://www.readbyqxmd.com/read/29304397/evaluation-of-a-novel-method-for-the-analysis-of-alcohol-biomarkers-ethyl-glucuronide-ethyl-sulfate-and-phosphatidylethanol
#1
Van Long Nguyen, Phillip Paull, Paul S Haber, Kate Chitty, Devanshi Seth
Currently available markers and methods to evaluate alcohol consumption are indirect and suboptimal, or rely on self-report, which have inherent problems. Direct metabolites of alcohol, phosphatidylethanol (PEth), ethyl sulfate (EtS), and ethyl glucuronide (EtG), are known to improve diagnostic accuracy. In this study, methods were established for the identification of PEth in erythrocytes and EtG and EtS in serum using ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The three biomarkers were tested and validated in volunteer teetotalers (n = 4) and drinkers (n = 10), and applied in patients (n = 8) hospitalized with alcohol-related problems...
August 31, 2017: Alcohol
https://www.readbyqxmd.com/read/29291550/filling-the-gap-between-lab-and-clinical-impact-an-open-randomized-diagnostic-trial-comparing-urinary-ethylglucuronide-and-ethanol-in-alcohol-dependent-outpatients
#2
Pablo Barrio, Lídia Teixidor, Lluisa Ortega, Anna Lligoña, Nayra Rico, José Luis Bedini, Eduard Vieta, Antoni Gual
BACKGROUND: Efforts aimed at reducing alcohol-related harm include early detection of risky drinkers as well as detection of early relapse in patients with alcohol dependence. Ethyl glucuronide (EtG) has been proven to be a reliable biomarker for the detection of recent drinking; however, no randomized, diagnostic trial to date has tested its impact on drinking outcomes. The aim of this study was to assess, in a randomized design, the implications of EtG screening on alcohol outcomes, compared to screening with a low sensitivity biomarker such as ethanol...
December 27, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29289821/maternal-hair-testing-to-disclose-self-misreporting-in-drinking-and-smoking-behavior-during-pregnancy
#3
Maria Dolores Gomez-Roig, Emilia Marchei, Sally Sabra, Francesco Paolo Busardò, Luisa Mastrobattista, Simona Pichini, Eduard Gratacós, Oscar Garcia-Algar
This study aimed to objectively verify smoking and drinking behavior during pregnancy and to disclose self-misreporting through maternal hair analysis. A total of 153 women attending a university hospital in Barcelona (Spain) were selected and interviewed after delivery, on their smoking and drinking habits during pregnancy. A 9-cm hair strand was collected and analyzed by liquid chromatography tandem mass spectrometry for the presence of nicotine (NIC) and ethyl glucuronide (EtG) as biomarkers of tobacco and alcohol consumption, respectively...
August 31, 2017: Alcohol
https://www.readbyqxmd.com/read/29206963/occupational-exposure-to-alcohol-based-hand-sanitizers-the-diagnostic-role-of-alcohol-biomarkers-in-hair
#4
A Salomone, A Bozzo, D Di Corcia, E Gerace, M Vincenti
Ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs) in hair are effective direct biomarkers of ethanol ingestion, whose analytical determination can be used to discriminate between chronic and occasional ethanol intake. Ethanol is a compound widely used in some workplaces (e.g., clinics, hospitals) and is present in considerable amounts in mouthwash for oral cleaning, medications, cosmetic products, hydro-alcoholic disinfectants and antiseptics for hands. This study examined the ethyl alcohol exposure derived from hand disinfectants (in gel form) by simulating the typical occupational situation of medical-health workers (healthcare workers, nurses, surgeons, etc...
December 1, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29182997/bioanalytical-methods-for-the-quantification-of-hydromorphone-fentanyl-norfentanyl-morphine-morphine-3%C3%A3-glucuronide-and-morphine-6%C3%A3-glucuronide-in-human-plasma
#5
Peter de Bruijn, Evelien J M Kuip, Mei-Ho Lam, Ron H J Mathijssen, Stijn L W Koolen
The aim of this study was to develop an assay for the quantification of hydromorphone, morphine, fentanyl and the metabolites norfentanyl, morphine-3ß-glucuronide and morphine-6ß-glucuronide in human plasma to support pharmacokinetic studies investigating the large interpatient variability in response to opioid treatment. For the quantitation of hydromorphone, morphine, fentanyl and its metabolite norfentanyl aliquots of 200μL human potassium EDTA plasma were deproteinized with deuterated internal standards in a mixture of acetonitrile and acetone, followed by a liquid-liquid extraction with 4% ammonium hydroxide and ethyl acetate...
November 17, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29174052/development-and-validation-of-a-partial-least-squares-discriminant-analysis-pls-da-model-based-on-the-determination-of-ethyl-glucuronide-etg-and-fatty-acid-ethyl-esters-faees-in-hair-for-the-diagnosis-of-chronic-alcohol-abuse
#6
E Alladio, L Giacomelli, G Biosa, D Di Corcia, E Gerace, A Salomone, M Vincenti
The chronic intake of an excessive amount of alcohol is currently ascertained by determining the concentration of direct alcohol metabolites in the hair samples of the alleged abusers, including ethyl glucuronide (EtG) and, less frequently, fatty acid ethyl esters (FAEEs). Indirect blood biomarkers of alcohol abuse are still determined to support hair EtG results and diagnose a consequent liver impairment. In the present study, the supporting role of hair FAEEs is compared with indirect blood biomarkers with respect to the contexts in which hair EtG interpretation is uncertain...
November 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29161228/homelessness-predicts-attrition-but-not-alcohol-abstinence-in-outpatients-experiencing-co-occurring-alcohol-dependence-and-serious-mental-illness
#7
Emily Leickly, Jordan Skalisky, Oladunni Oluwoye, Sterling M McPherson, Debra Srebnik, John M Roll, Richard K Ries, Michael G McDonell
BACKGROUND: Adults experiencing homelessness and serious mental illnesses (SMI) are at an increased risk for poor mental health and treatment outcomes compared to stably housed adults with SMI. The additional problem of alcohol misuse further complicates the difficulties of those living with homelessness and SMI. In this secondary data analysis, we investigated the impact of homelessness on attrition and alcohol use in a contingency management (CM) intervention that rewarded alcohol abstinence in outpatients with SMI...
November 21, 2017: Substance Abuse
https://www.readbyqxmd.com/read/29127890/the-role-of-ethyl-glucuronide-in-supporting-medico-legal-investigations-analysis-of-this-biomarker-in-different-postmortem-specimens-from-21-selected-autopsy-cases
#8
Anna Laura Santunione, Patrizia Verri, Filippo Marchesi, Cecilia Rustichelli, Federica Palazzoli, Daniele Vandelli, Manuela Licata, Enrico Silingardi
Ethanol determination in postmortem blood is one of the most frequently requested analyses in legal medicine and forensic toxicology. Ethyl glucuronide is a non-oxidative ethanol metabolite. It is also a useful marker of ante-mortem alcohol ingestion when ethanol itself has been completely eliminated from the body and could be considered in autopsy cases to obtain more reliable indications. The aim of the present study was to investigate the ethyl glucuronide distribution in postmortem specimens from autopsy cases found to be positive for ethanol...
November 1, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29101909/lessons-learned-from-a-case-of-tert-butyl-glucuronide-excretion-in-urine-new-psychoactive-alcohols-knocking-on-the-back-door
#9
Torsten Arndt, Hubert C Buschmann, Katja Schulz, Karsten Stemmerich
BACKGROUND: Ethyl glucuronide (EtG) in urine is considered a marker of recent ethanol consumption or ethanol exposition. tert-Butanol is primarily used as a solvent and intermediate chemical. Like tert-amyl alcohol, tert-butanol is discussed in Internet forums as ethanol replacement. We discuss false-positive immunological EtG screenings by excretion of different alcohol glucuronides (EtG homologs), mainly tert-butyl glucuronide in urine of a polytoxikomanic in-patient. METHODS: Three consecutive urine samples from an in-patient with a long history of multiple substance abuse including solvents were analyzed by DRI EtG enzyme immunoassay (ThermoFisher Scientific Microgenics) on a Beckman Coulter AU680 analyzer, an in-house LC-MS/MS for EtG, 1-propyl, 2-propyl, 1-butyl, 2-butyl, and tert-butyl glucuronide, and an in-house headspace GC-FID of free congener substances methanol, 1-propanol, 2-butanone, 2-butanol, isobutanol, 1-butanol, 3-methyl-1-butanol, 2-methyl-1-butanol, and additionally for ethanol, acetone, 2-propanol, tert-butanol and 2-methyl-2-butanol...
October 18, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29042582/portable-biosensor-for-monitoring-cortisol-in-low-volume-perspired-human-sweat
#10
David Kinnamon, Ramesh Ghanta, Kai-Chun Lin, Sriram Muthukumar, Shalini Prasad
A non-faradaic label-free cortisol biosensor was demonstrated using MoS2 nanosheets integrated into a nanoporous flexible electrode system. Low volume (1-5 μL) sensing was achieved through use of a novel sensor stack design comprised of vertically aligned metal electrodes confining semi-conductive MoS2 nanosheets. The MoS2 nanosheets were surface functionalized with cortisol antibodies towards developing an affinity biosensor specific to the physiological relevant range of cortisol (8.16 to 141.7 ng/mL) in perspired human sweat...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992662/sample-preparation-method-for-the-combined-extraction-of-ethyl-glucuronide-and-drugs-of-abuse-in-hair
#11
Ulf Christian Juhl Meier, Thomas Briellmann, Eva Scheurer, Franz Dussy
In hair analysis often little hair sample is available while the analysis of a multitude of structurally diverse substances with different concentration ranges is demanded. Often, the analysis of the different substances requires different sample preparation methods, increasing the amount of required hair sample. When segmental hair analysis is necessary, the amount of needed hair sample is further increased. Therefore, the required sample amount for a full analysis can quickly exceed the available hair sample...
October 9, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28982313/biomarkers-of-alcohol-consumption-in-body-fluids-possibilities-and-limitations-of-application-in-toxicological-analysis
#12
Mateusz K Woźniak, Marek Wiergowski, Jacek Namieśnik, Marek Biziuk
Ethyl alcohol is the most popular legal drug, but its excessive consumption causes social problems. Despite many public campaigns against alcohol use, car accidents, instances of aggressive behaviour, sexual assaults and deterioration in labor productivity caused by inebriated people is still commonplace. Fast and easy diagnosis of alcohol consumption is required in order to introduce proper and effective therapy, and is crucial in forensic toxicology analysis. The easiest method to prove alcohol intake is determination of ethanol in body fluids or in breath...
October 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28954578/portable-chronic-alcohol-consumption-monitor-in-human-sweat-through-square-wave-voltammetry
#13
David Kinnamon, Sriram Muthukumar, Anjan Panneer Selvam, Shalini Prasad
Chronic alcohol consumption is a significant financial and physical burden in the United States each year. Alcohol consumption monitors focus on establishing a state of intoxication, not assessing a user's health risks as a function of consumed alcohol. This work demonstrates a biosensor for a chronic alcohol consumption monitor through the electrochemical detection of ethyl glucuronide (EtG) in human sweat using square-wave voltammetry (SWV). A novel affinity assay was demonstrated in which monoclonal antibodies were chemically coabsorbed onto a gold electrode surface in parallel with thiolated charge transfer molecule...
September 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28938866/the-interpretation-of-hair-analysis-for-drugs-and-drug-metabolites
#14
Eva Cuypers, Robert J Flanagan
INTRODUCTION: Head hair analysis for drugs and drug metabolites has been used widely with the aim of detecting exposure in the weeks or months prior to sample collection. However, inappropriate interpretation of results has likely led to serious miscarriages of justice, especially in child custody cases. OBJECTIVE: The aim of this review is to assess critically what can, and perhaps more importantly, what cannot be claimed as regards the interpretation of hair test results in a given set of circumstances in order to inform future testing...
September 22, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28892761/ethyl-glucuronide-in-keratinous-matrices-as-biomarker-of-alcohol-use-a-correlation-study-between-hair-and-nails
#15
Delphine Cappelle, Hugo Neels, Steven De Keukeleire, Erik Fransen, Geert Dom, Annemie Vermassen, Adrian Covaci, Cleo L Crunelle, Alexander L N van Nuijs
To quantify alcohol use, objective, specific and sensitive long-term alcohol markers are necessary. Ethyl glucuronide (EtG), a direct metabolite of alcohol, accumulates in keratinous matrices such as hair and nails, and is a specific and sensitive long-term biomarker for the detection of chronic alcohol consumption. So far, research has primarily focused on the detection of EtG in hair, and studies on its measurement in nails are scarce. In this article, we assessed EtG concentrations in hair, finger- and toenails from the same individuals in order to evaluate the direct correlation between the matrices...
October 2017: Forensic Science International
https://www.readbyqxmd.com/read/28892122/effects-of-prenatal-alcohol-consumption-on-cognitive-development-and-adhd-related-behaviour-in-primary-school-age-a-multilevel-study-based-on-meconium-ethyl-glucuronide
#16
Anna Eichler, Linda Hudler, Juliane Grunitz, Jennifer Grimm, Eva Raabe, Tamme W Goecke, Peter A Fasching, Matthias W Beckmann, Oliver Kratz, Gunther H Moll, Johannes Kornhuber, Hartmut Heinrich
BACKGROUND: Alcohol intake during pregnancy is considered to be a risk factor for child development. Child biomarkers of intrauterine alcohol exposure have been rarely studied. We investigated whether a meconium alcohol metabolite (ethyl glucuronide, EtG) was associated with cognitive development, ADHD-related behaviour and neurophysiological markers of attention and executive control of children at primary-school age. METHODS: Mothers provided self-report on prenatal alcohol consumption during their 3rd trimester...
September 11, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28856820/decrease-of-ethyl-glucuronide-concentrations-in-hair-after-exposure-to-chlorinated-swimming-pool-water
#17
Marc Luginbühl, Susanne Nussbaumer, Wolfgang Weinmann
The direct alcohol marker ethyl glucuronide (EtG) is widely used for the assessment of alcohol consumption behavior and abstinence monitoring by hair analysis. We investigated the influence of chlorinated swimming pool water on EtG concentrations in hair in comparison to deionized water (Milli-Q) containing no chlorine. EtG concentrations were measured with a validated online-SPE-LC-MS/MS method. EtG positive hair samples were obtained from three regular drinkers and incubated for 0, 2, 4, 6, 8, and 10 hours at room temperature...
August 30, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28852244/value-of-ethyl-glucuronide-and-ethyl-sulfate-in-serum-as-biomarkers-of-alcohol-consumption
#18
Lekhansh Shukla, Priyamvada Sharma, Suhas Ganesha, Deepak Ghadigaonkar, Evan Thomas, Arun Kandasamy, Pratima Murthy, Vivek Benegal
BACKGROUND: Urinary Ethyl glucuronide (EtG) and Ethyl sulfate (EtS) are established markers of alcohol conumption. Measurement of these markers in serum offers certain advantages. This outpatient department based study evaluated performance of serum Ethyl glucuronide (EtG) and Ethyl sulphate (EtS) as biomarkers of recent alcohol consumption in alcohol dependent subjects. It also evaluated effect of alcohol dose and time since consumption on serum EtG and EtS concentration. METHODS: Information regarding alcohol intake was collected using Time line follow back calendar method from 152 subjects...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28833832/pretreatment-ethyl-glucuronide-levels-predict-response-to-a-contingency-management-intervention-for-alcohol-use-disorders-among-adults-with-serious-mental-illness
#19
Michael Gerard McDonell, Emily Leickly, Sterling McPherson, Jordan Skalisky, Katherine Hirchak, Oladunni Oluwoye, Debra Srebnik, John Michael Roll, Richard Kirkland Ries
BACKGROUND AND OBJECTIVES: This study investigated if pretreatment ethyl glucuronide (EtG) levels corresponding to light (100 ng/mL), heavy (500 ng/mL), and very heavy (1,000 ng/mL) drinking predicted longest duration of alcohol abstinence (LDA) and proportion of EtG-negative urine tests in outpatients receiving a 12-week EtG-based contingency management (CM) intervention for alcohol dependence. METHODS: Participants were 40 adults diagnosed with alcohol use disorders and serious mental illness who submitted up to 12 urine samples for EtG analysis during a 4-week observation period and were then randomized to 12-weeks of CM for alcohol abstinence and addiction treatment attendance...
October 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28832233/bioactivity-guided-isolation-and-identification-of-anti-adipogenic-compounds-from-sanguisorba-officinalis
#20
Sun Hyuk Im, Zhiqiang Wang, Soon Sung Lim, Ok-Hwan Lee, Il-Jun Kang
CONTEXT: Sanguisorba officinalis Linne (Rosaceae) is a medicinal plant used traditionally for the treatment of inflammatory and metabolic diseases in Korea, China, and Japan. In our previous study, a 50% ethanol extract inhibited fat accumulation in 3T3-L1 adipocytes. OBJECTIVE: This study investigates bioassay-guided fractionation, isolation, and identification of anti-adipogenic bioactive compounds in S. officinalis. MATERIALS AND METHODS: The bioassay-guided fractionation was conducted using effective differentiation of 3T3-L1 cells into adipocytes (with 50 μg/mL test material for 8 days) to isolate the inhibitory compounds from ethyl acetate fraction of S...
December 2017: Pharmaceutical Biology
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