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Ethyl glucuronide

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https://www.readbyqxmd.com/read/28340031/one-year-clinical-correlates-of-etg-positive-urine-screening-in-alcohol-dependent-patients-a-survival-analysis
#1
Pablo Barrio, Silvia Mondon, Lídia Teixidor, Lluisa Ortega, Eduard Vieta, Antoni Gual
Aims: Little evidence exists supporting the efficacy of regular alcohol urine screening (RAUS) in the management of alcohol dependence, despite recent improvements in urine biomarkers. In this study, we aimed at investigating 1 year, differential clinical correlates between a positive and a negative baseline urine ethyl glucuronide (EtG) screening. Methods: Alcohol-dependent outpatients participating in a previous cross-sectional study where EtG and ethanol diagnostic performances were compared in a double blind design were included...
March 10, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28335977/simultaneous-determination-of-ethanol-s-four-types-of-non-oxidative-metabolites-in-human-whole-blood-by-liquid-chromatography-tandem-mass-spectrometry
#2
Xinyu Zhang, Feng Zheng, Zebin Lin, Sys Stybe Johansen, Tianfang Yu, Yuming Liu, Zhibin Huang, Jiaolun Li, Jie Yan, Yulan Rao
The importance of ethanol non-oxidative metabolites as the specific biomarkers of alcohol consumption in clinical and forensic settings is increasingly acknowledged. Simultaneous determination of these metabolites can provide a wealth of information like drinking habit and history, but it was difficult to achieve because of their wide range of polarity. This work describes development and validation of a simple liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for 4 types of ethanol non-oxidative metabolites (ethyl glucuronide, ethyl sulfate, fatty acid ethyl esters and phosphatidylethanols) in 50 μL of human whole blood...
April 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28296341/distribution-pattern-of-ethyl-glucuronide-and-caffeine-concentrations-over-the-scalp-of-a-single-person-in-a-forensic-context
#3
Ulf Meier, Thomas Briellmann, Eva Scheurer, Franz Dussy
The distribution of analyte concentrations in hair across the scalp has not been thoroughly investigated. Differences in concentrations depending on sampling location are problematic, especially when measuring a second strand to confirm the result of the first measurement. Aiming at a better understanding of the concentration differences, the distribution of ethyl glucuronide (EtG) and caffeine concentrations in hair across the entire head of one test subject was investigated by dividing the scalp completely into regions of ca...
March 11, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28274229/exposure-to-phthalates-and-bisphenol-a-are-associated-with-atopic-dermatitis-symptoms-in-children-a-time-series-analysis
#4
Eun-Hye Kim, Byoung-Hak Jeon, Jihyun Kim, Young-Min Kim, Youngshin Han, Kangmo Ahn, Hae-Kwan Cheong
BACKGROUND: Despite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children. METHODS: We surveyed 18 boys with AD (age 3-7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary...
March 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28237885/assessment-of-tobacco-alcohol-and-cannabinoid-metabolites-in-645-meconium-samples-of-newborns-compared-to-maternal-self-reports
#5
Sandrine Lamy, Benjamin Hennart, Estelle Houivet, Sylvain Dulaurent, Heloise Delavenne, Jacques Benichou, Delphine Allorge, Stéphane Marret, Florence Thibaut
Prenatal psychoactive substance exposure has significant impact on neonatal health and child development and the development of reliable biomarkers is critical. Meconium presents several advantages for detecting prenatal exposure to psychoactive substances, as it is easy to collect and provides a broad time frame of exposure (third trimester). The aim of our study was to compare the prevalence of alcohol, tobacco and/or cannabis use during the third trimester of pregnancy (using maternal self-reports) with the results of meconium testing of their metabolites in newborns (cotinine, ethyl-glucuronide (EtG) and cannabinoid metabolites)...
February 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28135843/a-randomized-controlled-trial-of-ethyl-glucuronide-based-contingency-management-for-outpatients-with-co-occurring-alcohol-use-disorders-and-serious-mental-illness
#6
Michael G McDonell, Emily Leickly, Sterling McPherson, Jordan Skalisky, Debra Srebnik, Frank Angelo, Roger Vilardaga, Jenny R Nepom, John M Roll, Richard K Ries
OBJECTIVE: The authors examined whether a contingency management intervention using the ethyl glucuronide (EtG) alcohol biomarker resulted in increased alcohol abstinence in outpatients with co-occurring serious mental illnesses. Secondary objectives were to determine whether contingency management was associated with changes in heavy drinking, treatment attendance, drug use, cigarette smoking, psychiatric symptoms, and HIV-risk behavior. METHOD: Seventy-nine (37% female, 44% nonwhite) outpatients with serious mental illness and alcohol dependence receiving treatment as usual completed a 4-week observation period and were randomly assigned to 12 weeks of contingency management for EtG-negative urine samples and addiction treatment attendance, or reinforcement only for study participation...
January 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28126442/a-uhplc-ms-ms-method-for-simultaneous-determination-of-twelve-constituents-from-erigeron-breviscapus-extract-in-rat-plasma-application-to-a-pharmacokinetic-study
#7
Yuanyuan Tian, Qingqian Li, Xinpeng Zhou, Qian Pang, Yuanjin Xu
A rapid, sensitive and specific ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated to simultaneously determine the twelve major bioactive ingredients (neochlorogenic acid, chlorogenic acid, caffeic acid, cynarin, scopoletin, scutellarin, isochlorogenic acid A, apigenin-7-o-glucuronide, isochlorogenic acid C, scutellarein, luteolin, and apigenin) in rat plasma. Gallic acid and wogonoside were used as internal standards (IS1 and IS2). The plasma samples were pretreated and extracted by liquid-liquid extraction and protein precipitation with ethyl acetate-acetonitrile (95:5, v/v)...
January 17, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28107105/optimised-deconjugation-of-androgenic-steroid-conjugates-in-bovine-urine
#8
Mikael Pedersen, Henrik L Frandsen, Jens H Andersen
After administration of steroids to animals the steroids are partially metabolised in the liver and kidney to phase 2 metabolites, i.e., glucuronic acid or sulphate conjugates. During analysis these conjugated metabolites are normally deconjugated enzymatically with aryl sulphatase and glucuronidase resulting in free steroids in the extract. It is well known that some sulphates are not deconjugated using aryl sulphatase; instead, for example, solvolysis can be used for deconjugation of these aliphatic sulphates...
April 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28098942/biomarkers-for-the-detection-of-prenatal-alcohol-exposure-a-review
#9
REVIEW
Heidi Bager, Lars Porskjaer Christensen, Steffen Husby, Lene Bjerregaard
Alcohol exposure during pregnancy can cause adverse effects to the fetus, because it interferes with fetal development, leading to later physical and mental impairment. The most common clinical tool to determine fetal alcohol exposure is maternal self-reporting. However, a more objective and useful method is based on the use of biomarkers in biological specimens alone or in combination with maternal self-reporting. This review reports on clinically relevant biomarkers for detection of prenatal alcohol exposure (PAE)...
February 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28095285/urine-levels-of-phthalate-metabolites-and-bisphenol-a-in-relation-to-main-metabolic-syndrome-components-dyslipidemia-hypertension-and-type-2-diabetes-a-pilot-study
#10
Roman Piecha, Štěpán Svačina, Marek Malý, Karel Vrbík, Zdenka Lacinová, Martin Haluzík, Jana Pavloušková, Adam Vavrouš, Dagmar Matějková, Dana Müllerová, Miloš Mráz, Martin Matoulek
AIM: Human exposure to organic pollutants (some of them also called endocrine disruptors) can be associated with adverse metabolic health outcomes including type 2 diabetes. The goal of this study was to compare the urine levels of bisphenol A and phthalate metabolites in subgroups of patients with metabolic syndrome composed of patients with and without three important components of metabolic syndrome (hypertension, dyslipidemia and diabetes). METHODS: We have investigated 24 hr urine samples of 168 patients with metabolic syndrome from the Metabolic Outpatient Department of General University Hospital in Prague...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28063329/determination-of-ethyl-glucuronide-in-human-hair-samples-a-multivariate-analysis-of-the-impact-of-extraction-conditions-on-quantitative-results
#11
Alexander Mueller, Hilke Jungen, Stefanie Iwersen-Bergmann, Lars Raduenz, Susanne Lezius, Hilke Andresen-Streichert
BACKGROUND: Ethyl glucuronide (EtG), a minor metabolite of ethanol, is used as a direct alcohol biomarker for the prolonged detection of ethanol consumption. Hair testing for EtG offers retrospective, long-term detection of ethanol exposition for several months and has gained practical importance in forensic and clinical toxicology. Since quantitative results of EtG hair testings are included in interpretations, a rugged quantitation of EtG in hair matrix is important. As generally known, sample preparation is critical in hair testing, and the scope of this study was on extraction of EtG from hair matrix...
December 19, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28056375/evaluation-of-direct-and-indirect-ethanol-biomarkers-using-a-likelihood-ratio-approach-to-identify-chronic-alcohol-abusers-for-forensic-purposes
#12
Eugenio Alladio, Agnieszka Martyna, Alberto Salomone, Valentina Pirro, Marco Vincenti, Grzegorz Zadora
The detection of direct ethanol metabolites, such as ethyl glucuronide (EtG) and fatty acid ethyl esters (FAEEs), in scalp hair is considered the optimal strategy to effectively recognize chronic alcohol misuses by means of specific cut-offs suggested by the Society of Hair Testing. However, several factors (e.g. hair treatments) may alter the correlation between alcohol intake and biomarkers concentrations, possibly introducing bias in the interpretative process and conclusions. 125 subjects with various drinking habits were subjected to blood and hair sampling to determine indirect (e...
December 21, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28054395/inhalation-of-alcohol-vapor-measurement-and-implications
#13
REVIEW
Robert Ross MacLean, Gerald W Valentine, Peter I Jatlow, Mehmet Sofuoglu
Decades of alcohol research have established the health risks and pharmacodynamic profile of oral alcohol consumption. Despite isolated periods of public health concern, comparatively less research has evaluated exposure to alcohol vapor. Inhaled alcohol initially bypasses first-pass metabolism and rapidly reaches the arterial circulation and the brain, suggesting that this route of administration may be associated with pharmacological effects that increase the risk of addiction. However, detailed reviews assessing the possible effects of inhaled alcohol in humans are lacking...
February 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28024169/evaluation-of-kims-immunoassays-on-a-cobas-c-501-analyzer-for-drugs-of-abuse-and-ethyl-glucuronide-testing-in-urine-for-forensic-abstinence-control
#14
Merja A Neukamm, Arsham Bahrami, Volker Auwärter, Felix M P Mehne, Eva Höss
For the medico-psychological assessment (MPA) during driving licence re-granting in Germany, abstinence control including urine samples is required. In these programmes, even small amounts of markers for drug or alcohol abuse have to be detected. Thus, the concentrations of the target compounds are very low, and, in consequence, the sensitivity of the applied screening method has to be much higher than for clinical use. Modified drugs of abuse and ethyl glucuronide immunoassays on a Roche cobas c 501 analyzer were evaluated for precision, accuracy, onboard calibration stability, cross reactivity, sensitivity, and specificity using authentic urine samples...
December 26, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27998921/the-performance-of-alcohol-markers-including-ethyl-glucuronide-and-ethyl-sulphate-to-detect-alcohol-use-in-clients-in-a-community-alcohol-treatment-programme
#15
Jane M Armer, Lihini Gunawardana, Rebecca L Allcock
AIMS: The ethanol metabolites ethyl glucuronide (EtG) and ethyl sulphate (EtS) are detectable for longer in urine than breath ethanol or urine ethanol after alcohol intake. This study compared the performance of breath ethanol, urine ethanol, urine EtG and EtS to detect alcohol consumption in clients in community alcohol treatment. METHODS: Clients attending the community alcohol treatment programme were asked to provide an alcohol diary, breathalyser test and urine for ethanol, EtG and EtS measurement (n = 42)...
January 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27920527/pharmacokinetics-and-safety-of-dts-108-a-human-oligopeptide-bound-to-sn-38-with-an-esterase-sensitive-cross-linker-in-patients-with-advanced-malignancies-a-phase-i-study
#16
Romain Coriat, Sandrine J Faivre, Olivier Mir, Chantal Dreyer, Stanislas Ropert, Mohammed Bouattour, Robert Desjardins, François Goldwasser, Eric Raymond
BACKGROUND: DTS-108 is a hydrosoluble prodrug, where the SN-38 moiety is covalently linked to a 20-amino acid vector peptide by a specific esterase-sensitive cross-linker, releasing 7-ethyl-10-hydroxycampthotecin (SN-38) by esterase bond cleavage. METHODS: The pharmacokinetics of DTS-108, adverse events graded according to NCI-CTCv3.1, dose-limiting toxicities at cycle 1, the maximum tolerated dose (MTD), and the recommended Phase II dose (RP2D) of intravenous DTS-108 (1-2 hours) every 2 weeks were evaluated in a first-in-human Phase I study in patients with advanced/metastatic carcinomas, according to an accelerated dose escalation design...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27888306/a-simple-analytical-method-of-determining%C3%A2-1-hydroxypyrene-glucuronide-in-human-urine-by-isotope-dilution-with-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#17
Mingxin Li, Qian Wang, Jing Zhu, Nana Li, Xiaoli Zou
The glucuronide conjugate of 1-hydroxypyrene (1-OHP-G) is a sensitive and reliable index biomarker for assessing low exposure to polycyclic aromatic hydrocarbons (PAHs). A simple method for determining 1-OHP-G in human urine with ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established and applied to evaluate the exposure level of PAHs of pregnant women in a large sample size. After the urine sample was extracted with ethyl acetate, 0.2 mL of the aqueous phase was diluted to 1...
November 25, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27813358/alcohol-use-disorders-in-australia
#18
C H Freyer, K C Morley, P S Haber
Alcohol use disorders are common in Australia and are often unrecognised. Alcohol places a significant burden on our healthcare system by increasing the risk of injuries as well as many chronic medical conditions. Diagnosis requires a high index of suspicion and can be aided by the use of specific questionnaires, such as the Alcohol Use Disorder Identification Test-C. The current available laboratory tests are of limited sensitivity and specificity, but can nevertheless aid in the diagnosis in some circumstances...
November 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27798076/etg-and-ets-in-autopsy-blood-samples-with-and-without-putrefaction-using-uplc-ms-ms
#19
Solfrid Hegstad, Lena Kristoffersen, Veronica H Liane, Olav Spigset
Analytical challenges related to postmortem specimens are well known. The degree of putrefaction of the corpse will influence the quality of the blood samples, and both the efficiency of sample preparation and the subsequent chromatographic performance can be affected. An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the determination of ethyl glucuronide (EtG) and ethyl sulfate (EtS) in postmortem whole blood. Sample preparation prior to UPLC-MS-MS analysis consisted of protein precipitation and filtration through a phospholipid removal plate...
October 26, 2016: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/27797711/influence-of-body-mass-index-on-hair-ethyl-glucuronide-concentrations
#20
Cleo L Crunelle, Hugo Neels, Kristof Maudens, Mireille De Doncker, Delphine Cappelle, Frieda Matthys, Geert Dom, Erik Fransen, Peter Michielsen, Steven De Keukeleire, Adrian Covaci, Michel Yegles
AIM: Analysis of ethyl glucuronide (EtG) concentrations in hair is increasingly used to estimate the consumption of alcohol of the prior months. Linear correlations between the amount of alcohol consumed and the concentration of EtG in hair have been reported, and several variables that may influence this correlation have been investigated: e.g. cosmetic hair treatments, gender influences or hair color. Here, we investigate the influence of body mass index (BMI) on this correlation. METHODS: A post hoc analysis on the influence of BMI on the relation between amounts of alcohol consumed and the measured EtG concentrations in hair in 199 participants...
January 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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