Myrtle F Krul, Niels F M Kok, Harun Osmani, Florian E Buisman, Bas Groot Koerkamp, Dirk J Grunhagen, Cornelis Verhoef, Bianca Mostert, Petur Snaebjornsson, Bram Westerink, Elisabeth G Klompenhouwer, Maarten L Donswijk, Theo J M Ruers, Joeri A J Douma, Nico van Blijderveen, T Peter Kingham, Michael I D'Angelica, Nancy E Kemeny, Karen Bolhuis, Tineke E Buffart, Koert F D Kuhlmann
BACKGROUND: Hepatic arterial infusion pump chemotherapy combined with systemic chemotherapy (HAIP-SYS) for liver-only colorectal liver metastases (CRLMs) has shown promising results but has not been adopted worldwide. This study evaluated the feasibility of HAIP-SYS in the Netherlands. METHODS: This was a single-arm phase II study of patients with CRLMs who received HAIP-SYS consisting of floxuridine with concomitant systemic FOLFOX or FOLFIRI. Main inclusion and exclusion criteria were borderline resectable or unresectable liver-only metastases, suitable arterial anatomy and no previous local treatment...
April 3, 2024: British Journal of Surgery