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https://www.readbyqxmd.com/read/29045241/taking-assent-to-new-heights-a-case-report-on-do-not-resuscitate-status-in-pediatric-palliative-care-procedures
#1
Heather A Ballard, Santhanam Suresh
Dying adolescents presenting for palliative procedures have complicated developmental and ethical issues, especially when reconsidering do-not-resuscitate orders. Though the American Academy of Pediatrics has guidelines, there is limited information in the literature on how to take care of these patients. We describe the case of a 14-year-old patient presenting to the interventional radiology suite for management of superior vena cava syndrome. The patient's goals of treatment were elucidated through a comprehensive care team consisting of the procedural and oncology teams...
October 17, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29036345/phase-ii-study-of-cabozantinib-in-patients-with-progressive-glioblastoma-subset-analysis-of-patients-with-prior-antiangiogenic-therapy
#2
Timothy F Cloughesy, Jan Drappatz, John de Groot, Michael D Prados, David A Reardon, David Schiff, Marc Chamberlain, Tom Mikkelsen, Annick Desjardins, Jerry Ping, Jaymes Holland, Ron Weitzman, Patrick Y Wen
Background: Cabozantinib is a potent, multi-target inhibitor of hepatocyte growth factor receptor (MET) and vascular endothelial growth factor receptor-2 (VEGFR2). This open-label, phase II trial evaluated cabozantinib in patients with recurrent or progressive glioblastoma (GBM; NCT00704288). Methods: Patients were initially enrolled to a starting cabozantinib dose of 140 mg/day, but the starting dose was amended to 100 mg/day because of safety concerns. Treatment continued until disease progression or unacceptable toxicity...
October 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29030073/comparative-analysis-of-surgery-thermal-ablation-and-active-surveillance-for-renal-oncocytic-neoplasms
#3
Brady L Miller, Lori Mankowski Gettle, Jason R Van Roo, Timothy J Ziemlewicz, Sara L Best, Shane A Wells, Meghan G Lubner, J Louis Hinshaw, Fred T Lee, Stephen Y Nakada, Wei Huang, E Jason Abel
OBJECTIVE: To compare oncologic and procedural outcomes for renal oncocytic tumors treated with surgery, thermal ablation or active surveillance. METHODS AND MATERIALS: Clinical and pathologic data were collected for consecutive patients with a histological diagnosis of oncocytoma, oncocytic neoplasm or chromophobe renal cell cancers (chRCC) from 2003-2016. Independent pathology and radiology review was performed for this study. RESULTS: Of 171 patients, tumor histology included oncocytoma (n=122), chRCC (n=47) and oncocytic neoplasm not otherwise specified (n=2)...
October 10, 2017: Urology
https://www.readbyqxmd.com/read/29028102/the-ten-commandments-of-hepatic-radioembolization-expert-discussion-and-report-from-mediterranean-interventional-oncology-miolive-congress-2017
#4
J L Bilbao, R Iezzi, S N Goldberg, A Sami, O Akhan, F Giuliante, M Pompili, L Crocetti, K Malagari, V Valentini, A Gasbarrini, C Colosimo, R Manfredi
Microsphere and particle technology represent the next-generation agents that have formed the basis of interventional oncology, an evolving subspecialty of interventional radiology. One of these platforms, yttrium-90 microspheres, is increasingly being used as a treatment modality for primary and secondary liver tumors. Due to the widespread use of radioembolization, a comprehensive review of the methodologic and technical considerations seems to be mandatory. This article summarizes the expert discussion and report from Mediterranean Interventional Oncology Live Congress (MIOLive 2017) that was held in Rome, Italy, integrating evidence-reported literature and experience-based perceptions, to assist not only residents and fellows who are training in interventional radiologists but also practicing colleagues who are approaching to this intra-arterial treatment...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29025982/appropriate-use-criteria-for-somatostatin-receptor-pet-imaging-in-neuroendocrine-tumors
#5
Thomas A Hope, Emily Bergsland, Murat Fani Bozkurt, Michael M Graham, Anthony P Heaney, Ken Herrmann, James R Howe, Matthew H Kulke, Pamela L Kunz, Josh Mailman, Lawrence May, David C Metz, Corina Millo, Sue O'Dorisio, Diane L Reidy-Lagunes, Michael C Soulen, Jonathan R Strosberg
Somatostatin receptor positron emission tomography (SSTR-PET) is an imaging modality for patients with neuroendocrine tumors (NETs) that has demonstrated a significant improvement over conventional imaging (CI). SSTR-PET should replace In-111 pentetreotide scintigraphy (OctreoScan) in all indications in which SSTR scintigraphy is currently being used. These appropriate use criteria (AUC) are intended to aid referring medical practitioners in the appropriate use of SSTR-PET for imaging of patients with NETs, and the indications were evaluated in well-differentiated NETs...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29021951/marrow-signal-mimicking-tumor-on-mri-t1-weighted-imaging-after-neoadjuvant-chemotherapy-in-extremity-osteosarcomas
#6
Zhiping Deng, Yi Ding, Lin Hao, Qing Zhang, Yongbin Su, Xiaohui Niu
PURPOSE: Many studies had demonstrated that MRI T1-weighted imaging was the most accurate method to evaluate the intramedullary extent of extremity osteosarcoma. However, we found that after neoadjuvant chemotherapy new low signal of MRI T1 imaging was detected near tumor, which mimicked the tumor progression. The aim of this study was to describe the incidence and type of this new signal, to reveal the pathological correlation with this imaging change. METHODS: We included 74 extremity osteosarcomas managed between June 2011 and November 2012 in this retrospective study...
March 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/28989237/lipofilling-effects-after-breast-cancer-surgery-in-post-radiation-patients-an-analysis-of-results-and-algorithm-proposal
#7
Manuel Debald, Thomas Pech, Christina Kaiser, Mignon-Denise Keyver-Paik, Gisela Walgenbach-Bruenagel, Joerg C Kalff, Walther Kuhn, Klaus J Walgenbach
BACKGROUND: Lipofilling or autologous fat transfer is an established technique in plastic surgery. Herein, we describe the lipofilling effects after implant-based breast reconstruction in post-radiation patients and propose an algorithm for indication of lipofilling. METHODS: Forty patients with a history of breast cancer were included in this retrospective analysis. Patients had undergone either breast conserving therapy or mastectomy. Twenty-six patients underwent additional radiation therapy...
2017: European Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28987630/mri-texture-analysis-reflects-histopathology-parameters-in-thyroid-cancer-a-first-preliminary-study
#8
Hans-Jonas Meyer, Stefan Schob, Anne Kathrin Höhn, Alexey Surov
OBJECT: Thyroid cancer represents the most frequent malignancy of the endocrine system with an increasing incidence worldwide. Novel imaging techniques are able to further characterize tumors and even predict histopathology features. Texture analysis is an emergent imaging technique to extract extensive data from an radiology images. The present study was therefore conducted to identify possible associations between texture analysis and histopathology parameters in thyroid cancer. METHODS: The radiological database was retrospectively reviewed for thyroid carcinoma...
October 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28984116/cerebellar-liponeurocytoma-with-atypical-histological-features-a-rare-example-of-a-glioneuronal-tumor
#9
Blanka Hermann, Michal Woznica, Wojciech Kloc, Piotr Borkowski, Witold Libionka, Ewa Izycka-Swieszewska
We present a case of a rare neoplasm in a 77-year-old woman with previous oncological history, who developed a rapid onset of cerebellar symptoms. The neuroimaging detected a posterior fossa tumor suspected of meningioma which was completely resected soon after. Histologically the neoplasm had two components with different immunophenotype. One constituent was lobular, composed of monotonous mitotically active round cells with a predominant neuronal profile. The second, astrocytic component contained lipomatous cells intermixed with larger gemistocytic astrocytes...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28982791/radiomics-in-brain-tumor-image-assessment-quantitative-feature-descriptors-and-machine-learning-approaches
#10
REVIEW
M Zhou, J Scott, B Chaudhury, L Hall, D Goldgof, K W Yeom, M Iv, Y Ou, J Kalpathy-Cramer, S Napel, R Gillies, O Gevaert, R Gatenby
Radiomics describes a broad set of computational methods that extract quantitative features from radiographic images. The resulting features can be used to inform imaging diagnosis, prognosis, and therapy response in oncology. However, major challenges remain for methodologic developments to optimize feature extraction and provide rapid information flow in clinical settings. Equally important, to be clinically useful, predictive radiomic properties must be clearly linked to meaningful biologic characteristics and qualitative imaging properties familiar to radiologists...
October 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28975117/clinical-practice-and-outcomes-in-advanced-gastrointestinal-stromal-tumor-experience-from-an-indian-tertiary-care-center
#11
Subhadeep Bose, Anant Ramaswamy, Arvind Sahu, Omshree Shetty, Saurabh S Zanwar, Jimmy Mirani, Chaitali Nashikkar, Vikas Ostwal
BACKGROUND: Management of advanced Gastrointestinal stromal tumors (GIST) has been revolutionized with the use of Imatinib guided by mutation analysis. Data from India remains scarce. MATERIALS AND METHODS: Patients with metastatic GIST who were treated at Department of Gastro-intestinal & Hepaticopancreaticobiliary Oncology Unit at Tata Memorial Hospital, Mumbai between December, 2004 and December 2015 were included in the analysis. Clinical and radiological data was retrieved from stored medical records and charts...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28974857/a-phantom-study-on-fetal-dose-reducing-factors-in-pregnant-patients-with-breast-cancer-during-radiotherapy-treatment
#12
Akın Öğretici, Aydın Çakır, Uğur Akbaş, Canan Köksal, Ümmühan Kalafat, Makbule Tambaş, Hatice Bilge
PURPOSE: This study aims to investigate the factors that reduce fetal dose in pregnant patients with breast cancer throughout their radiation treatment. Two main factors in a standard radiation oncology center are considered as the treatment planning systems (TPSs) and simple shielding for intensity modulated radiation therapy technique. MATERIALS AND METHODS: TPS factor was evaluated with two different planning algorithms: Anisotropic analytical algorithm and Acuros XB (external beam)...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28974597/selective-internal-radiation-therapy-for-liver-tumours
#13
Francis X Sundram, John R Buscombe
Primary and secondary liver malignancies are common and associated with a poor prognosis. Surgical resection is the treatment of choice; however, many patients have unresectable disease. In these cases, several liver directed therapies are available, including selective internal radiation therapy (SIRT). SIRT is a multidisciplinary treatment involving nuclear medicine, interventional radiology and oncology. High doses of localised internal radiation are selectively delivered to liver tumour tissues, with relative sparing of adjacent normal liver parenchyma...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28963046/introducing-a-simple-method-of-maxillary-sinus-volume-assessment-based-on-linear-dimensions
#14
Agnieszka Przystańska, Tomasz Kulczyk, Artur Rewekant, Alicja Sroka, Katarzyna Jończyk-Potoczna, Dorota Lorkiewicz-Muszyńska, Krzysztof Gawriołek, Agata Czajka-Jakubowska
Measuring sinus volume in a general practice clinic is a complex and time-consuming procedure, requiring experience in the use of radiological methods In the presented research, the automatically estimated maxillary sinus volume was compared with maxillary sinus volume assessed with mathematical formulas used to calculate the volume of spheres and pyramids. The starting point for the statistical analysis were specific measurements of the sinuses. We wanted to discover which geometric shape has the volume that is nearest to the automatically estimated volume...
September 28, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28953945/incidence-and-clinical-features-of-the-incidentally-found-vascular-stump-thrombus-during-routine-follow-up-after-oncologic-lung-surgery
#15
Mi Hyoung Moon, Kyongmin Sarah Beck, Young Kyu Moon, Jae Kil Park, Sook Whan Sung
OBJECTIVES: We aimed to evaluate the incidence and clinical features of vascular stump thrombus after oncologic lung surgery. METHODS: A retrospective analysis of records from our institutional database dated between 2009 and 2016 was performed. Data regarding demographics, clinical presentation, medication use, operative findings, pathology, and radiologic findings were retrieved. RESULTS: The study cohort consisted of 648 oncologic surgeries for primary lung cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28946909/ct-imaging-features-associated-with-recurrence-in-non-small-cell-lung-cancer-patients-after-stereotactic-body-radiotherapy
#16
Qian Li, Jongphil Kim, Yoganand Balagurunathan, Jin Qi, Ying Liu, Kujtim Latifi, Eduardo G Moros, Matthew B Schabath, Zhaoxiang Ye, Robert J Gillies, Thomas J Dilling
BACKGROUND: Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investigate the association of imaging features derived from the first follow-up computed tomography (CT) on lung cancer patient outcomes following SBRT, and identify patients at high risk of recurrence. METHODS: Fifty nine biopsy-proven non-small cell lung cancer patients were qualified for this study...
September 25, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28934820/-bone-metastases-pathophysiology-diagnostic-testing-and-therapy-part-1
#17
Sebastian Koob, Michael Kehrer, Andreas Strauss, Viktor Janzen, Dieter Christian Wirtz, Jan Schmolders
In Germany and other European countries, cancer is the second most common cause of death after cardiovascular disease. Although 5-year survival rates for several types of cancer have significantly improved over the last 30 years, metastasis to the bone almost always leads to incurable disease. Aside from the rare primary bone tumours, the treatment of bone metastases now accounts for a major part of tumour orthopaedic workload and requires close interdisciplinary coordination between specialists in oncology, radiology and the discipline of the primary tumour entity...
September 21, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28928820/management-of-supratentorial-recurrent-low-grade-glioma-a-multidisciplinary-experience-in-35-adult-patients
#18
Julien Spitaels, Daniel Devriendt, Niloufar Sadeghi, Sylvie Luce, Olivier De Witte, Serge Goldman, Christian Mélot, Florence Lefranc
The management of recurrent diffuse low-grade gliomas (LGGs) is controversial. In the present study, the multidisciplinary management of 35 patients with recurrent LGGs was retrospectively analyzed. Tumor progression or recurrence was defined by clinical, radiological and/or metabolic pejorative evolution. All patients were regularly followed up by a multidisciplinary neuro-oncological group at Hôpital Erasme. Patients with histologically confirmed supratentorial LGGs (7 astrocytoma, 22 oligodendrogliomas and 6 oligoastrocytomas) who had undergone surgery between August 2004 and November 2010 were included...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927746/-proposal-of-screening-for-diffuse-low-grade-gliomas-in-the-population-from-20-to-40years
#19
Emmanuel Mandonnet, Luc Taillandier, Hugues Duffau
Diffuse low-grade gliomas (DLGG) are cerebral tumors occurring in young adults, with an inescapable progression to higher grade of malignancy, resulting in functional impairment and death. DLGG evolve in several phases: an asymptomatic period despite a slow radiological growth; a period in which inaugural symptoms occur, usually epilepsy with possible mild cognitive disorders; then a phase with malignant transformation generating disabling neurological deficits; and ultimately the terminal stage. Early maximal surgical resection significantly increases overall survival while preserving quality of life...
September 15, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28927109/disease-progression-patterns-of-bevacizumab-responders-with-recurrent-malignant-gliomas
#20
Ju-Hwi Kim, Tae-Young Jung, Eu Chang Hwang, Sung-Hoon Jung, Shin Jung, In-Young Kim, Woo-Youl Jang, Kyung-Sub Moon, Kyung-Hwa Lee, Seul-Kee Kim
Tumor progression in patients with recurrent malignant glioma who respond to bevacizumab (BEV) is difficult to assess. The current study reviewed the clinical and radiological results of patients following a BEV-based chemotherapy regimen, and evaluated disease progression patterns in patients who responded to BEV therapy. From August 2011 to November 2015, 24 patients (18 glioblastoma cases and 6 anaplastic astrocytoma cases) were treated with BEV-based chemotherapy. In total, 6 patients were treated with BEV alone and 18 patients were treated with BEV combined with irinotecan...
September 2017: Oncology Letters
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