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https://www.readbyqxmd.com/read/29908990/development-and-validation-of-response-markers-to-predict-survival-and-pleurodesis-success-in-patients-with-malignant-pleural-effusion-promise-a-multicohort-analysis
#1
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry, Marie Laëtitia Thézénas, Philip D Charles, Anastasia Samsonova, Herbert B Schiller, Roman Fischer, Rachelle Asciak, Robert J Hallifax, Rachel Mercer, Melissa Dobson, Tao Dong, Ian D Pavord, Gary S Collins, Benedikt M Kessler, Harvey I Pass, Nick Maskell, Georgios T Stathopoulos, Najib M Rahman
BACKGROUND: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival. METHODS: In this multicohort study, we used five separate and independent datasets from randomised controlled trials to investigate potential biomarkers of survival and pleurodesis...
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29907512/thoughts-on-the-american-board-of-radiology-examinations-and-the-resident-experience-in-radiation-oncology
#2
EDITORIAL
Paul E Wallner, Lisa A Kachnic, Anthony M Gerdeman
No abstract text is available yet for this article.
April 10, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907338/artificial-intelligence-in-radiation-oncology-a-specialty-wide-disruptive-transformation
#3
REVIEW
Reid F Thompson, Gilmer Valdes, Clifton D Fuller, Colin M Carpenter, Olivier Morin, Sanjay Aneja, William D Lindsay, Hugo J W L Aerts, Barbara Agrimson, Curtiland Deville, Seth A Rosenthal, James B Yu, Charles R Thomas
Artificial intelligence (AI) is emerging as a technology with the power to transform established industries, and with applications from automated manufacturing to advertising and facial recognition to fully autonomous transportation. Advances in each of these domains have led some to call AI the "fourth" industrial revolution [1]. In healthcare, AI is emerging as both a productive and disruptive force across many disciplines. This is perhaps most evident in Diagnostic Radiology and Pathology, specialties largely built around the processing and complex interpretation of medical images, where the role of AI is increasingly seen as both a boon and a threat...
June 12, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29900651/surgery-in-ovarian-cancer-brazilian-society-of-surgical-oncology-consensus
#4
REVIEW
Audrey Tieko Tsunoda, Reitan Ribeiro, Rosilene Jara Reis, Carlos Eduardo Mattos da Cunha Andrade, Renato Moretti Marques, Glauco Baiocchi, Fabio Fin, Paulo Henrique Zanvettor, Deraldo Falcao, Thales Paulo Batista, Bruno Roberto Braga Azevedo, Gustavo Guitmann, Suzana Arenhart Pessini, João Soares Nunes, Leonardo Martins Campbell, José Clemente Linhares, Felipe José Fernandez Coimbra
Surgical management in epithelial ovarian cancer (EOC) has a significant impact in overall survival (OS) and progression free survival (PFS). Brazilian Society of Surgical Oncology (BSSO) supported a taskforce with experts for consensus: experienced and specialized trained surgeons, in cancer centers, provide the best EOC surgery. Laparoscopic and/or radiological staging prognosticate the possibility of complete cytoreduction (CC0) and help to reduce unnecessary laparotomies. Surgical techniques were reviewed...
June 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29899760/appraisal-of-the-role-of-radical-prostatectomy-for-rhabdomyosarcoma-in-children-oncological-and-urological-outcome
#5
Lorenzo Angelini, Gianni Bisogno, Ciro Esposito, Marco Castagnetti
The latest multimodal protocols for treatment of bladder/prostate rhabdomyosarcoma (RMS) have shifted the goal of treatment from patient survival to bladder preservation. Consistently, partial resections, such as radical prostatectomy (RP), are favoured when surgery is deemed necessary. We sought to determine the oncological risks - that is, failure to achieve disease control - and the possible benefits in terms of urinary continence associated with RP in RMS patients based on a review of our experience and the data reported in the literature...
June 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29898894/clinical-predictors-of-successful-and-earlier-pleurodesis-with-a-tunnelled-pleural-catheter-in-malignant-pleural-effusion-a-cohort-study
#6
Pen Li, Alison Graver, Sarah Hosseini, Sunita Mulpuru, Lorraine Cake, Lynn Kachuik, Tinghua Zhang, Kayvan Amjadi
BACKGROUND: Tunnelled pleural catheters used to treat malignant pleural effusions may achieve pleurodesis. We aimed to identify factors associated with higher pleurodesis rates and earlier catheter removal. METHODS: We retrospectively reviewed a prospective database of tunnelled pleural catheters inserted consecutively between May 2006 and June 2013 for confirmed malignant pleural effusion. The cohort included patients who underwent medical thoracoscopy. Clinical, radiologic and pleural fluid data were recorded...
April 2018: CMAJ Open
https://www.readbyqxmd.com/read/29891263/treatment-design-and-rationale-for-a-randomized-trial-of-prophylactic-cranial-irradiation-with-or-without-hippocampal-avoidance-for-sclc-premer-trial-on-behalf-of-the-oncologic-group-for-the-study-of-lung-cancer-spanish-radiation-oncology-group-radiation-oncology
#7
Nuria Rodríguez de Dios, Felipe Couñago, José Luis López, Patricia Calvo, Mauricio Murcia, Mikel Rico, Carmen Vallejo, Javier Luna, Itziar Trueba, Cristina Cigarral, Nuria Farre, Rosa Maria Manero, Xavier Durán, Pilar Samper
BACKGROUND: Prophylactic cranial irradiation (PCI) is part of the usual treatment in most patients with small-cell lung cancer (SCLC) and response after treatment of the primary tumor. Clinical evidence suggests that radiation dose received by the hippocampus during whole brain radiotherapy might play a role in radiation-induced neurocognitive decline. PATIENTS AND METHODS: This study is a multicenter phase III trial (NCT02397733) randomizing SCLC patients after informed consent, to receive standard PCI treatment or PCI with hippocampus avoidance (PCI-HA) by using intensity modulated radiation therapy or volumetric modulated arc therapy...
May 10, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29887695/inadequately-staged-endometrial-cancer-a-clinical-dilemma
#8
Vinotha Thomas, Anitha Thomas, Ajit Sebastian, Rachel Chandy, Abraham Peedicayil
Incidental diagnosis of carcinoma endometrium following hysterectomy requires clinical expertise from a gynecologic oncologist, with regard to subsequent management. We report our experience with completion staging in endometrial cancer, to determine the benefits and risks of completion staging in women with posthysterectomy diagnosis of endometrial cancer. DESIGN: A retrospective case series of 20 women with postoperative diagnosis of endometrial cancer, who had undergone completion staging...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29875066/pembrolizumab-in-patients-with-advanced-hepatocellular-carcinoma-previously-treated-with-sorafenib-keynote-224-a-non-randomised-open-label-phase-2-trial
#9
Andrew X Zhu, Richard S Finn, Julien Edeline, Stephane Cattan, Sadahisa Ogasawara, Daniel Palmer, Chris Verslype, Vittorina Zagonel, Laetitia Fartoux, Arndt Vogel, Debashis Sarker, Gontran Verset, Stephen L Chan, Jennifer Knox, Bruno Daniele, Andrea L Webber, Scot W Ebbinghaus, Junshui Ma, Abby B Siegel, Ann-Lii Cheng, Masatoshi Kudo
BACKGROUND: Immune checkpoint blockade therapy has shown promising results in patients with advanced hepatocellular carcinoma. We aimed to assess the efficacy and safety of pembrolizumab in this patient population. METHODS: KEYNOTE-224 is a non-randomised, multicentre, open-label, phase 2 trial that is set in 47 medical centres and hospitals across ten countries. Eligible patients had pathologically confirmed hepatocellular carcinoma; had previously been treated with sorafenib and were either intolerant to this treatment or showed radiographic progression of their disease after treatment; an Eastern Cooperative Oncology Group performance status of 0-1; adequate organ function, and were Child-Pugh class A...
June 1, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29872643/three-dimensional-map-of-isoprognostic-zones-in-glottic-cancer-treated-by-transoral-laser-microsurgery-as-a-unimodal-treatment-strategy
#10
Cesare Piazza, Marta Filauro, Alberto Paderno, Filippo Marchi, Pietro Perotti, Riccardo Morello, Stefano Taboni, Giampiero Parrinello, Fabiola Incandela, Andrea Iandelli, Francesco Missale, Giorgio Peretti
Introduction: The Union for International Cancer Control-American Joint Committee on Cancer TNM staging system for glottic squamous cell carcinoma (SCC) includes different types of lesions defined by the involvement of specific subsites in each T category. Our study aims to identify different subcategories according to tumor local extension and determine oncologic outcomes after treatment by transoral laser microsurgery (TLM) alone. Methods: We retrospectively evaluated 410 patients affected by previously untreated pT1-pT3 glottic SCC treated by TLM alone from January 2005 to December 2015 at the Departments of Otorhinolaryngology-Head and Neck Surgery, Universities of Genoa and Brescia, Italy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29862084/precision-medicine-for-breast-cancer-the-paths-to-truly-individualized-diagnosis-and-treatment
#11
REVIEW
Eleanor E R Harris
Precision medicine in oncology seeks to individualize each patient's treatment regimen based on an accurate assessment of the risk of recurrence or progression of that person's cancer. Precision will be achieved at each phase of care, from detection to diagnosis to surgery, systemic therapy, and radiation therapy, to survivorship and follow-up care. The precision arises from detailed knowledge of the inherent biological propensities of each tumor, rather than generalizing treatment approaches based on phenotypic, or even genotypic, categories...
2018: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/29860889/texture-analysis-on-diffusion-tensor-imaging-discriminating-glioblastoma-from-single-brain-metastasis
#12
Karoline Skogen, Anselm Schulz, Eirik Helseth, Balaji Ganeshan, Johann Baptist Dormagen, Andrès Server
Background Texture analysis has been done on several radiological modalities to stage, differentiate, and predict prognosis in many oncologic tumors. Purpose To determine the diagnostic accuracy of discriminating glioblastoma (GBM) from single brain metastasis (MET) by assessing the heterogeneity of both the solid tumor and the peritumoral edema with magnetic resonance imaging (MRI) texture analysis (MRTA). Material and Methods Preoperative MRI examinations done on a 3-T scanner of 43 patients were included: 22 GBM and 21 MET...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29852148/significance-of-lymphadenectomy-in-part-solid-lung-adenocarcinoma-propensity-score-matched-analysis
#13
Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
BACKGROUND: It is evident that the frequency of nodal metastasis in part-solid lung adenocarcinoma is significantly low. For those cases, the prognostic impact of the lymph nodal dissection is highly controversial. METHODS: We reviewed 462 clinical-stage I radiological part-solid lung adenocarcinoma patients who underwent lobectomy or segmentectomy with lymphadenectomy. Consolidation tumor ratio (CTR) was evaluated for all patients. Extent of LNDs was classified into systematic/lobe-specific mediastinal-LND (m-LND) and hilar-LND only (h-LND)...
May 28, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29850162/mucinous-cystadenocarcinoma-arising-from-mucinous-cystadenoma-of-the-lung-case-report-and-review-of-the-literature
#14
Isabelle Moneke, Christoph Zeisel, Mirjam Elze, Benedikt Haager, Bernward Passlick, Gian Kayser
Mucinous cystadenoma is a benign tumor commonly found in the pancreas, the ovaries or the appendix. Only very few cases of these tumors originating from the lungs have been reported worldwide, with even less cases describing malignant transformation. We present the case of a 58-year-old woman with a history of recurrent pulmonary infections who underwent left upper lobectomy for lung abscess and was initially diagnosed with pulmonary mucinous cystadenoma (PMCA). Upon thorough immunohistochemical workup, especially due to carcinoembryonic antigen (CEA) positivity, intramucinous singlet cells were eventually diagnostic for invasive carcinoma, in this case a mucinous cystadenocarcinoma arising from a PCMA...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29804825/system-redesign-of-a-radiology-research-clinic-for-oncology-clinical-trial-patients
#15
Lauren Gjolaj, Avantika Dang, Helen Peck, Jonathan Trent, Rosa Patricia Castillo
No abstract text is available yet for this article.
May 24, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29795015/multidisciplinary-approach-for-bone-metastasis-a-review
#16
REVIEW
Takahiro Kimura
Progress in cancer treatment has improved the survival of patients with advanced-stage cancers. Consequently, the clinical courses of patients are prolonged and often accompanied by morbidity due to bone metastases. Skeletal-related events (SREs), such as pathological fractures and spinal paralysis, cause impairment in activities of daily life and quality of life (QOL). To avoid serious SREs causing impairment in QOL and survival, early diagnosis and a prophylactic approach are required. It is necessary to initiate a bone management program concurrently with the initiation of cancer treatment to prevent complications of bone metastasis...
May 24, 2018: Cancers
https://www.readbyqxmd.com/read/29785528/a-rare-case-of-ascending-colon-adenocarcinoma-incarcerated-in-an-inguinoscrotal-hernia-case-report-and-literature-review
#17
Tien Yew Chern, Yeng Kwang Tay, Dayashan Shevantha Perera
BACKGROUND: Inguinal hernias and colorectal cancers are common conditions, but the presentation of a loop of bowel containing cancer within a hernia is rare. Principles of surgery include oncological resection of the involved colonic segment as well as lymphatic drainage. Based on case reports of the last several decades, there have been no reports of a case where the reduction of an inguinoscrotal hernia and oncological colectomy were performed completely laparoscopically. We present the first instance of a completely laparoscopically assisted resection and hernia repair on a patient with T4 ascending colon cancer...
May 21, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29781463/hepatic-arterial-infusion-pump-complications-and-nursing-management-regarding-use-in-patients-with-colorectal-cancer
#18
Deborah Italiano
BACKGROUND: The hepatic arterial infusion (HAI) pump is a treatment-delivery method based on the principle of targeting the tumor site directly and can be used alone or in combination with systemic chemotherapy. OBJECTIVES: The intent of this article is to serve as a resource for oncology nurses to safely identify and manage HAI pump complications. These complications include seroma, flipped HAI pump, infection, changes in pressure and temperature, challenging access, dry pump, high residual volume, chemical hepatitis, risk of ulcer, and radiologic imaging considerations...
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29777175/artificial-intelligence-in-radiology
#19
REVIEW
Ahmed Hosny, Chintan Parmar, John Quackenbush, Lawrence H Schwartz, Hugo J W L Aerts
Artificial intelligence (AI) algorithms, particularly deep learning, have demonstrated remarkable progress in image-recognition tasks. Methods ranging from convolutional neural networks to variational autoencoders have found myriad applications in the medical image analysis field, propelling it forward at a rapid pace. Historically, in radiology practice, trained physicians visually assessed medical images for the detection, characterization and monitoring of diseases. AI methods excel at automatically recognizing complex patterns in imaging data and providing quantitative, rather than qualitative, assessments of radiographic characteristics...
May 17, 2018: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/29771224/discipline-specific-competency-based-curricula-for-leadership-learning-in-medical-specialty-training
#20
Sandra Turner, Ming-Ka Chan, Judy McKimm, Graham Dickson, Timothy Shaw
Purpose Doctors play a central role in leading improvements to healthcare systems. Leadership knowledge and skills are not inherent, however, and need to be learned. General frameworks for medical leadership guide curriculum development in this area. Explicit discipline-linked competency sets and programmes provide context for learning and likely enhance specialty trainees' capability for leadership at all levels. The aim of this review was to summarise the scholarly literature available around medical specialty-specific competency-based curricula for leadership in the post-graduate training space...
May 8, 2018: Leadership in Health Services
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