Ulrich Gergs, Maren L Büxel, Merlin Bresinsky, Uwe Kirchhefer, Charlotte Fehse, Carina Höring, Britt Hofmann, Margareta Marusakova, Aneta Čináková, Rebecca Schwarz, Steffen Pockes, Joachim Neumann
In an integrative approach, we studied cardiac effects of recently published novel H2 receptor agonists in the heart of mice that overexpress the human H2 receptor (H2 -TG), littermate wild type control mice (WT) and in isolated electrically driven muscle preparations from patients undergoing cardiac surgery. Under our experimental conditions, the H2 receptor agonists UR-Po563, UR-MB-158 and UR-MB-159 increased force of contraction in left atrium from H2 -TG with pEC50 values of 8.27, 9.38, and 8.28, respectively, but not in WT...
September 17, 2021: Journal of Pharmacology and Experimental Therapeutics