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https://www.readbyqxmd.com/read/29906814/magnoflorine-enhances-lps-activated-pro-inflammatory-responses-via-myd88-dependent-pathways-in-u937-macrophages
#1
Md Areeful Haque, Ibrahim Jantan, Hemavathy Harikrishnan, Siti Mariam Abdul Wahab
Magnoflorine, a major bioactive metabolite isolated from Tinospora crispa, has been reported for its diverse biochemical and pharmacological properties. However, there is little report on its underlying mechanisms of action on immune responses, particularly on macrophage activation. In this study, we aimed to investigate the effects of magnoflorine, isolated from T. crispa on the pro-inflammatory mediators generation induced by LPS and the concomitant NF- κ B, MAPKs, and PI3K-Akt signaling pathways in U937 macrophages...
June 15, 2018: Planta Medica
https://www.readbyqxmd.com/read/29906812/congenital-arteriovenous-malformation-of-the-scalp-involving-the-orbit
#2
Alberto Feletti, Stavros Dimitriadis, Stefano Vallone, Giacomo Pavesi
BACKGROUND:  Arteriovenous malformations (AVMs) of the scalp are rare and infrequently encountered by the neurosurgeon. CASE DESCRIPTION:  We report a unique case of a 42-year-old patient who presented with a progressive worsening of visual acuity in the right eye (lower quadrantanopia) and palpebral ptosis. Physical examination revealed a right exophthalmos and a right frontoparietal scalp soft swelling when the patient was in the supine position. Neurologic work-up showed a scalp AVM extending into the orbit and connected to an intraorbital cavernous angioma...
June 15, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29906811/comparison-of-hand-sewn-versus-coupled-venous-anastomoses-in-traumatic-lower-extremity-reconstruction
#3
John T Stranix, William J Rifkin, Z-Hye Lee, Lavinia Anzai, Adam Jacoby, Daniel J Ceradini, Vishal Thanik, Pierre B Saadeh, Jamie P Levine
BACKGROUND:  Microvascular reconstruction of the lower extremity has the highest reported complication and flap failure rates of any anatomical region. Despite widespread adoption of the mechanical anastomotic venous coupler and encouraging results in other anatomical regions, there are limited reports examining its use in the lower extremity. This study compares outcomes between coupled and hand-sewn venous anastomoses in traumatic lower extremity reconstruction. METHODS:  Retrospective review of our institutional flap registry from 1979 to 2016 identified soft tissue free flaps performed for the reconstruction of Gustilo type IIIB/IIIC open tibial fractures...
June 15, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29906795/national-survey-of-neonatal-intensive-care-unit-medication-safety-practices
#4
Rachel G Greenberg, P Brian Smith, Carl Bose, Reese H Clark, C Michael Cotten, Chris DeRienzo
OBJECTIVE:  We conducted a detailed survey to identify medication safety practices among a large network of United States neonatal intensive care units (NICUs). METHODS:  We created a 53-question survey to assess 300 U.S. NICU's demographics, medication safety practices, adverse drug event (ADE) reporting, and ADE response plans. RESULTS:  Among the 164 (55%) NICUs that responded to the survey, more than 85% adhered to practices including use of electronic health records, computerized physician order entry, and clinical decision support; fewer reported adopting barcoding, formal safety surveys, and formal culture training; 137 of 164 (84%) developed at least one NICU-specific order-set with a median of 10 order-sets...
June 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29906794/development-of-a-hybrid-course-on-wheelchair-service-provision-for-clinicians-in-international-contexts
#5
Yohali Burrola-Mendez, Mary Goldberg, Rachel Gartz, Jon Pearlman
INTRODUCTION: Wheelchair users worldwide are at high risk of developing secondary health conditions and premature death due to inappropriate wheelchair provision by untrained providers. The International Society of Wheelchair Professionals (ISWP) has developed a Hybrid Course based on the World Health Organization's Wheelchair Service Training Package-Basic Level. The Hybrid Course leverages online modules designed for low-bandwidth internet access that reduces the in-person training exposure from five to three and a half days, making it less expensive and more convenient for both trainees and trainers...
2018: PloS One
https://www.readbyqxmd.com/read/29906787/overall-cortisol-diurnal-slope-and-stress-reactivity-in-psychosis-an-experience-sampling-approach
#6
Thomas Vaessen, Zuzana Kasanova, Dennis Hernaus, Johan Lataster, Dina Collip, Martine van Nierop, Inez Myin-Germeys
OBJECTIVE: Results from experimental studies suggest that psychosis and psychosis liability are associated with increased cortisol levels and blunted cortisol reactivity, and that use of antipsychotics may reduce these aberrations. Here, we report on overall cortisol, diurnal slope, and cortisol stress reactivity in everyday life in psychosis and psychosis liability using the experience sampling method (ESM). METHODS: Our sample consisted of individuals diagnosed with psychotic disorder currently on (MPD; n = 53) or off antipsychotic medication (NMPD; n = 20), first-degree relatives of psychotic patients (REL; n = 47), and healthy volunteers (HV; n = 67)...
June 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29906780/in-vivo-evaluation-of-the-response-of-galleria-mellonella-larvae-to-novel-copper-ii-phenanthroline-phenazine-complexes
#7
Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Malachy McCann, Andrew Kellett, Orla Howe, Kevin Kavanagh
Herein we report the in-vivo characterisation and metabolic changes in Galleria mellonella larvae to a series of bis-chelate copper(II) phenanthroline-phenazine cationic complexes of [Cu(phen)2 ]2+ (Cu-Phen), [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen) and [Cu(DPPZ)(Phen)]2+ (Cu-DPPZ-Phen) (where phen = 1,10-phenanthroline, DPQ = dipyrido[3,2-ƒ:2',3'-h]quinoxaline and DPPZ = dipyrido[3,2-a:2',3'-c]phenazine). Our aim was to investigate the influence of the systematic extension of the ligated phenazine ligand in the G...
June 1, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29906771/academic-stress-and-active-learning-of-nursing-students-a-cross-sectional-study
#8
Nicola Magnavita, Carlo Chiorri
BACKGROUND: The active role of nursing students is particularly important in the delivery of health care, since playing an active role at the bedside and the use of active and collaborative engagement of students in the nursing activities has been associated with improved student learning. This is consistent with Karasek's learning hypothesis, but it has never been tested on nursing students. This study aimed at investigating whether nursing students in high control conditions reported lower levels of work impairment than students in the conditions with low control, compared them with a group of healthcare workers (HCWs), and tested the moderating role of social support at work...
June 8, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29906768/in-vitro-analysis-of-various-cell-lines-responses-to-electroporative-electric-pulses-by-means-of-electrical-impedance-spectroscopy
#9
Tomás García-Sánchez, Ramon Bragós, Lluis M Mir
This paper reports the comparative analysis, by means of electric impedance spectroscopy measurements, of three different cell lines subjected to electroporative pulses. The multifrequency information is recorded simultaneously at 21 frequency values in the range between 5 kHz and 1.3 MHz using a multisine based measuring approach. The analysis of the pre-electroporation impedance spectra shows how the system is able to detect differences and similarities between the cell lines under analysis. Particularly, a good agreement is found between the average cell diameter and the characteristic frequency (the frequency corresponding to a maximum in the imaginary part of the impedance)...
June 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29906757/transport-of-oxaliplatin-species-in-water-saturated-natural-soil
#10
Natalia Goykhman, Ishai Dror, Brian Berkowitz
This study reports the transport characteristics of the organometallic anticancer compound oxaliplatin and its derivatives in natural soil-water environments. Although pharmaceuticals and their derivatives have for many years been detected in water resources, and linked to toxicological impacts on ecological systems, their transport in soil and groundwater is not fully understood. Specifically, studies that describe transport of organometallic pharmaceuticals in porous media are rare, and the transport characteristics of platinum complexes have received little attention...
June 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29906749/long-non-coding-rna-linc00339-facilitates-the-tumorigenesis-of-non-small-cell-lung-cancer-by-sponging-mir-145-through-targeting-foxm1
#11
Yuan Yuan, Gao Haiying, Li Zhuo, Lu Ying, He Xin
Non-small cell lung cancer (NSCLC) is one of leading causes of cancer-related death worldwide. Long noncoding RNAs (lncRNAs) has been identified to modulate the tumorigenesis of NSCLC. However, the precise molecular mechanism of lncRNAs in the course is still unclear. Results showed that LINC00339 was significantly up-regulated in NSCLC tissue and cells, which indicated the poor prognosis of NSCLC patients. Loss-of-function experiments showed that LINC00339 silencing inhibited the proliferation and invasion, accelerated the apoptosis, and suppressed the tumor growth of NSCLC cells in vitro and in vivo...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906746/linc-pou3f3-is-overexpressed-in-hepatocellular-carcinoma-and-regulates-cell-proliferation-migration-and-invasion
#12
Yichun Li, Yannan Li, Dan Wang, Qingdong Meng
Linc-POU3F3 showed an up-regulated tendency and functioned as tumor promoter in glioma, esophageal cancer and colorectal cancer. There was no report about the expression pattern and clinical value of linc-POU3F3 in hepatocellular carcinoma. Thus, the purpose of our study is to explore the clinical significance and biological role of linc-POU3F3 in hepatocellular carcinoma. Our results suggested that levels of linc-POU3F3 were dramatically increased in hepatocellular carcinoma tissues and cell lines compared with paired normal hepatic tissues and normal hepatic cell line, respectively...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906745/long-noncoding-rna-linc00460-targets-mir-539-mmp-9-to-promote-meningioma-progression-and-metastasis
#13
Hongshun Xing, Shilei Wang, Quancai Li, Yongqian Ma, Peng Sun
Emerging evidence reveal that long noncoding RNAs (lncRNAs) participates in the epigenetic regulation of pathophysiological process. However, the deepgoing role of lncRNAs on meningioma is still unclear. In present study, we investigate the roles of lncRNA LINC00460 in meningeoma tissue and uncover its molecular mechanism. Results revealed that LINC00460 expression level was significantly up-regulated in meningeoma tissues and malignant meningeoma cell lines (IOMM-Lee, CH157-MN). Mechanically, loss-of-function assays showed that LINC00460 knockdown significantly suppressed the proliferation ability, increased the apoptosis and decreased the proteins (MMP-2, MMP-9, ZEB1) expression...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906744/microrna-302c-represses-epithelial-mesenchymal-transition-and-metastasis-by-targeting-transcription-factor-ap-4-in-colorectal-cancer
#14
Wenqi Ma, Bailing Liu, Jie Li, Jue Jiang, Ru Zhou, Lili Huang, Xiaopeng Li, Xin He, Qi Zhou
MicroRNAs (miRNAs) contribute to tumorigenesis and progression via acting as tumor suppressors or oncogenes in human cancer. Aberrant expression of miR-302c has been reported in various types of cancer except colorectal cancer (CRC). Thus, our study was aimed to verify the expression of miR-302c and its functional role in CRC. We found a significant reduced expression of miR-302c in CRC tissues compared to tumor-adjacent tissues. Low miR-302c level was remarkably correlated with deeper tumor invasion, lymph node metastasis and advanced TNM stage...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906743/costunolide-ameliorates-lipoteichoic-acid-induced-acute-lung-injury-via-attenuating-mapk-signaling-pathway
#15
Zhengxu Chen, Dan Zhang, Man Li, Baolong Wang
Lipoteichoic acid (LTA)-induced acute lung injury (ALI) is an experimental model for mimicking Gram-positive bacteria-induced pneumonia that is a refractory disease with lack of effective medicines. Here, we reported that costunolide, a sesquiterpene lactone, ameliorated LTA-induced ALI. Costunolide treatment reduced LTA-induced neutrophil lung infiltration, cytokine and chemokine production (TNF-α, IL-6 and KC), and pulmonary edema. In response to LTA challenge, treatment with costunolide resulted less iNOS expression and produced less inflammatory cytokines in bone marrow derived macrophages (BMDMs)...
June 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29906742/xanthohumol-attenuates-cisplatin-induced-nephrotoxicity-through-inhibiting-nf-%C3%AE%C2%BAb-and-activating-nrf2-signaling-pathways
#16
Fan Li, Yunyi Yao, Hui Huang, Hua Hao, Mingzhong Ying
Cisplatin is a chemotherapeutic agent that widely used in the treatment of cancer. However, cisplatin has been reported to induce nephrotoxicity by directly inducing inflammatory response and oxidative stress. In this study, we aimed to investigate the protective effects and mechanism of xanthohumol on cisplatin-induced nephrotoxicity. The model of nephrotoxicity was induced by intraperitoneal injection of cisplatin and xanthohumol was given intraperitoneally for three consecutive days. The results showed that xanthohumol significantly attenuated kidney histological changes and serum creatinine and BUN production...
June 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29906731/the-impact-of-fire-on-the-geochemistry-of-speleothem-forming-drip-water-in-a-sub-alpine-cave
#17
Katie Coleborn, Andy Baker, Pauline C Treble, Martin S Andersen, Andrew Baker, Carol V Tadros, Mark Tozer, Ian J Fairchild, Andy Spate, Sophia Meehan
Fire dramatically modifies the surface environment by combusting vegetation and changing soil properties. Despite this well-documented impact on the surface environment, there has been limited research into the impact of fire events on karst, caves and speleothems. Here we report the first experiment designed to investigate the short-term impacts of a prescribed fire on speleothem-forming cave drip water geochemistry. Before and after the fire, water was collected on a bi-monthly basis from 18 drip sites in South Glory Cave, New South Wales, Australia...
June 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29906729/atmospheric-particle-bound-organophosphate-ester-flame-retardants-and-plasticizers-in-a-north-african-mediterranean-coastal-city-bizerte-tunisia
#18
Javier Castro-Jiménez, Richard Sempéré
Organophosphate ester (OPE) flame retardants and plasticizers have been detected at generally high frequencies (70-98%) for the first time in the atmosphere over the NW African coastal Mediterranean. Results from sixty air samples (total suspended particles, TSP) collected between March 2015 and January 2016 in an urban coastal site (Bizerte, Tunisia) revealed ∑9 OPE concentrations of ~100-1060 pg m-3 (470 pg m-3 , median) with TCPPs, EHDPP and TiBP exhibiting the higher median concentrations (~110, 100 and 85 pg m-3 , respectively)...
June 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29906718/review-adjunctive-pharmacologic-approaches-for-benzodiazepine-tapers
#19
REVIEW
Justine W Welsh, Valeria Tretyak, R Kathryn McHugh, Roger D Weiss, Olivera Bogunovic
BACKGROUND: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints. METHODS: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term...
May 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29906710/a-meta-analysis-of-cytokine-concentrations-in-eating-disorders
#20
REVIEW
Bethan Dalton, Savani Bartholdy, Lauren Robinson, Marco Solmi, Mohammad A A Ibrahim, Gerome Breen, Ulrike Schmidt, Hubertus Himmerich
Cytokines are signalling molecules, which play an important role in both immune system function and brain development and function, and subsequently mental states and behaviour. Cytokines have been implicated in eating disorders (EDs) due to their role in psychological health, body weight and appetite regulation. This meta-analysis examined cross-sectional and longitudinal studies measuring concentrations of cytokines in individuals with EDs. Using PRISMA guidelines, we systematically reviewed relevant articles in PubMed, Web of Science, and MEDLINE...
June 7, 2018: Journal of Psychiatric Research
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