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https://www.readbyqxmd.com/read/27900043/second-look-surgery-following-hartmann-s-procedure-for-obstructive-left-sided-colorectal-cancer
#1
Naohito Beppu, Fumihiko Kimura, Nagahide Matsubara, Masashi Noda, Naohiro Tomita, Hidenori Yanagi, Naoki Yamanaka
The aim of the present study was to investigate the short- and long-term outcomes of patients undergoing second-look surgery following Hartmann's procedure for obstructive left-sided colorectal cancer (LSCC). All patients included in the present study had undergone radical surgery with Hartmann's procedure for obstructive LSCC. Adjuvant chemotherapy was recommended for all patients, and patients with no signs of recurrence following six months of surveillance were planned to undergo second-look surgery. The aim of second-look surgery was early detection of local recurrence and determination of the efficacy of laparoscopic Hartmann procedure reversal...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27824253/a-comparative-pre-phase-i-study-of-the-impact-of-gel-vehicle-volume-on-distal-colon-distribution-user-experience-and-acceptability
#2
Ethel D Weld, Hiwot Hiruy, Kate Morrow Guthrie, Joseph L Fava, Sara Vargas, Karen W Buckheit, Robert W Buckheit, Hans Spiegel, Jennifer C Breakey, Edward J Fuchs, Craig W Hendrix
For persons at risk of HIV infection who practice receptive anal intercourse (RAI), topical rectal microbicides represent a promising option for coitally-dependent protection. The study compared colorectal distribution and user sensory experiences of two different volumes of rectal gel for suitability as rectal microbicide. Eight HIV negative men with a history of recent RAI were enrolled into a two-period, sequence randomized, dosing study comparing 3.5 mL and 10 mL of radiolabeled (1 mCi 99mTc-DTPA) universal placebo hydroxyethyl cellulose (HEC) gel...
November 8, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27768599/a-role-for-the-vitamin-d-pathway-in-non-intestinal-lesions-in-genetic-and-carcinogen-models-of-colorectal-cancer-and-in-familial-adenomatous-polyposis
#3
Yong-Sik Bong, Shahin Assefnia, Therese Tuohy, Deborah W Neklason, Randall W Burt, Jaeil Ahn, Hao-Wen J Jiang, Stephen W Byers
Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/β-catenin/TCF tumor suppressor pathway. The vitamin D receptor (VDR) is also implicated in cardiovascular and skin diseases as well as in immunity. Activated VDR can indirectly alter β-catenin nuclear localization and directly suppress β-catenin/TCF mediated transcriptional activity. We treated VDR null mice with the carcinogen azoxymethane (AOM) and generated mice bearing a mutated APC (hypomorph) on a VDR null background (Apc1638N/+Vdr-/-)...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27704244/laparoscopic-surgery-in-patients-with-colon-cancer-a-population-based-analysis
#4
Stefan Benz, Hagen Barlag, Michael Gerken, Alois Fürst, Monika Klinkhammer-Schalke
BACKGROUND: The long-term outcomes after laparoscopic surgery for colon cancer remain debatable, as randomized trials have reported similar outcomes for open and laparoscopic surgery but population-based data are scarce. Thus, it is unclear whether, outside of clinical trials, laparoscopic surgery that is performed as a standard clinical treatment has detrimental effects on patients' long-term survival. METHODS: This study examined a unified database of 30 German regional cancer registries for patients with colorectal cancer who were diagnosed between 2003 and 2011...
October 4, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27686516/the-association-between-location-age-and-advanced-colorectal-adenoma-characteristics-a-propensity-matched-analysis
#5
Hans-Christian Pommergaard, Jakob Burcharth, Jacob Rosenberg, Hans Raskov
PURPOSE: Evidence supports an association between certain colorectal adenoma characteristics and predisposition to cancer. The association between anatomical location of colorectal adenoma, age and advanced adenomas needs attention. The objective of this study was to evaluate the possible association between occurrence of sporadic advanced adenomas with location and age. MATERIALS AND METHODS: A cross-sectional study using baseline data from index colonoscopy from a randomized controlled trial evaluating chemopreventive treatment against recurrence of colorectal adenomas was performed...
August 16, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27629565/selection-process-can-improve-the-outcome-in-locally-advanced-and-recurrent-colorectal-cancer-activity-and-results-of-a-dedicated-multidisciplinary-colorectal-cancer-centre
#6
Christos Kontovounisios, Emile Tan, Nikhil Pawa, Gina Brown, Diana Tait, David Cunningham, Shahnawaz Rasheed, Paris Tekkis
AIM: There is wide disparity in the care of patients with multi-visceral involvement of rectal cancer. The results of treatment of advanced and recurrent colorectal cancer are presented from a centre where a dedicated Multidisciplinary Team (MDT) is central to the management. METHOD: All consecutive MDT referrals between 2010 and 2014 were examined. Analysis was undertaken of the referral pathway, site, selection process, management decision, R0 resection rate, mortality / morbidity / Clavien-Dindo (CD) classification of morbidity, length of stay (LOS), and improvement of quality of life...
September 15, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27572063/accuracy-of-preoperative-tumor-localization-in-large-bowel-using-3d-magnetic-endoscopic-imaging-randomized-clinical-trial
#7
Miroslaw Szura, Artur Pasternak, Rafal Solecki, Maciej Matyja, Antoni Szczepanik, Andrzej Matyja
BACKGROUND: Laparoscopic surgery has become the standard treatment for colorectal cancer. A tumor that does not involve serosa is invisible intraoperatively, and manual palpation of the tumor during laparoscopy is not possible. Therefore, accurate localization of the neoplastic infiltrate remains one of the most important tasks prior to elective laparoscopic surgery. The aim of this study was to evaluate the utility of a magnetic endoscopic imaging (MEI) for precise preoperative endoscopic localization of neoplastic infiltrate within the large bowel...
August 29, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27566017/trends-in-lymph-node-excision-and-impact-of-positive-lymph-node-ratio-in-patients-with-colectomy-for-primary-colon-adenocarcinoma-population-based-study-1988-to-2011
#8
Brandon Garcia, Carlos Guzman, Christopher Johnson, Nicholas J Hellenthal, Daphne Monie, Jose Raul Monzon
BACKGROUND: Studies suggest increased lymph node excision in patients with colon cancer portends improved survival. Guidelines recommend excising 12 or more lymph nodes during colectomy. There is an inverse correlation between the positive lymph node ratio and survival in patients of these patients. OBJECTIVE: We sought to determine whether colon cancer patients have adequate lymph node excision and whether positive lymph node ratio can be used as a guiding factor for their treatment plan...
September 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27542763/-positron-emission-tomography-pet-in-gastro-intestinal-cancer
#9
Myriam Wartski
The existing recommendations for fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) use in digestive cancers (excluding neuroendocrine tumours) are summarized in the present article. FDG-PET/CT is nowadays a routine imaging modality for digestive malignancies and its use is currently increasing. FDG-PET/CT is considered to be a crucial tool in pretherapeutic assessment of esophageal, localized pancreatic and anal cancer. It represents a key exam in suspicion of recurrence of colorectal cancer in case of elevated serum tumor markers...
September 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27475305/regular-aspirin-use-associates-with-lower-risk-of-colorectal-cancers-with-low-numbers-of-tumor-infiltrating-lymphocytes
#10
Yin Cao, Reiko Nishihara, Zhi Rong Qian, Mingyang Song, Kosuke Mima, Kentaro Inamura, Jonathan A Nowak, David A Drew, Paul Lochhead, Katsuhiko Nosho, Teppei Morikawa, Xuehong Zhang, Kana Wu, Molin Wang, Wendy S Garrett, Edward L Giovannucci, Charles S Fuchs, Andrew T Chan, Shuji Ogino
BACKGROUND & AIMS: Aspirin use reduces colorectal cancer risk. Aspirin, a nonsteroidal anti-inflammatory drug, inhibits prostaglandin-endoperoxide synthase 2 (PTGS2 or cyclooxygenase-2); PTGS2 promotes inflammation and suppresses T-cell-mediated adaptive immunity. We investigated whether the inverse association of aspirin use with colorectal carcinoma risk was stronger for tumors with lower degrees of lymphocytic infiltrates than for tumors with higher degrees of lymphocytic infiltrates...
July 27, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27467330/-the-effect-of-oxygen-on-endotoxin-production-in-bacteria-of-the-bacteroides-fragilis-group-isolated-from-patients-with-colorectal-carcinoma
#11
D Chmelař, M Hájek, J Janečková, J Vobejdová, P Martineková, A Kašíková
OBJECTIVE: The aim of the study was to draw attention to the risk posed by anaerobic bacteria of the Bacteroides fragilis (BAFR) group, isolated particularly from abdominal lesions, and to assess the possible role of these species in colorectal cancer. A correlation has previously been suggested between the detection of the bacteria of the genus Bacteroides in patients on a meat-based diet and intestinal and, in particular, colorectal cancer. Given that the species of the BAFR group are major producers of endotoxins, measurements and statistical analysis of endotoxin production were used to compare the Bacteroides strains isolated from clinical specimens of patients with colon cancer, rectal cancer, and other abdominal lesions...
2016: Epidemiologie, Mikrobiologie, Imunologie
https://www.readbyqxmd.com/read/27458493/laparoscopic-and-natural-orifice-transluminal-restorative-proctocolectomy-no-abdominal-incision-for-specimen-extraction-or-ileostomy
#12
Cuneyt Kayaalp, Mehmet Ali Yagci, Vural Soyer
The aim of this study was to demonstrate the feasibility of laparoscopic restorative proctocolectomy (LRPC) without additional abdominal incisions. Two sisters with familial adenomatous polyposis were enrolled. The colon and rectum were mobilized entirely through the five abdominal trocars. The terminal ileum and distal rectum were transected with endoscopic staplers. The entire colorectal specimen was extracted transanally. A circular stapler anvil was introduced transanally. The J-pouch was created intracorporeally...
2016: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/27456545/two-stage-laparoscopic-curative-resection-for-synchronous-multiple-colorectal-cancers-a-case-report
#13
Rina Takahashi, Kazuhiro Sakamoto, Yuichi Tomiki, Yutaka Kojima, Makoto Takahashi, Kiichi Sugimoto, Masaya Kawai, Yu Okazawa, Yurika Makino
A 75-year-old man tested positive for occult blood in the stool. A subsequent examination indicated concurrent locally advanced cancer (cT3) at the hepatic flexure and lower rectum cancer in the external anal sphincter. Because of the locally advanced rectal cancer (cT4), preoperative chemoradiotherapy was administered. First, laparoscopic right hemicolectomy and colostomy were performed at the sigmoid colon. Chemoradiotherapy for rectal cancer was initiated on day 18 after the surgeries. Seven weeks after chemoradiotherapy had been completed, laparoscopic abdominoperineal resection and right lateral pelvic lymph node dissection were performed...
July 26, 2016: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/27446464/laparoscopic-subtotal-colectomy-for-synchronous-triple-colorectal-cancer-a-case-report
#14
Xuetong Jiang, Chuanqi Xu, Dong Tang, Daorong Wang
Synchronous colorectal cancers refer to the simultaneous occurrence of multiple colorectal tumors in a single patient, excluding any metastases from other organs. At present, radical surgery is considered the standard curative treatment; however, individualized surgical strategies depend on tumor location, the depth of invasion and the general health of the patient. In the present study, the case of a 52-year-old man who presented with a 2-month history of abdominal pain that was accompanied by intermittent hematochezia and weight loss is reported...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27353095/-advances-of-minimally-invasive-technique-in-colorectal-cancer-surgery
#15
Xishan Wang
Colorectal surgery is rapidly developing in the direction of minimally invasive surgery and functional surgery. New technology and ideas are constantly emerging recently. Laparoscopic colon surgery has already been recommended by NCCN guideline. However, laparoscopic rectal cancer surgery still needs to wait for survival and recurrence rates of long-term follow-up data for verification. In recent years, with the rapid progression of imaging equipment of laparoscope, the new 3D laparoscopic system will process image more quickly, and surgeons can get space depth feeling like open surgery only with a pair of glasses...
June 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27333993/colorectal-cancer-mortality-trends-in-serbia-during-1991-2010-an-age-period-cohort-analysis-and-a-joinpoint-regression-analysis
#16
Milena Ilic, Irena Ilic
BACKGROUND: For both men and women worldwide, colorectal cancer is among the leading causes of cancer-related death. This study aimed to assess the mortality trends of colorectal cancer in Serbia between 1991 and 2010, prior to the introduction of population-based screening. METHODS: Joinpoint regression analysis was used to estimate average annual percent change (AAPC) with the corresponding 95% confidence interval (CI). Furthermore, age-period-cohort analysis was performed to examine the effects of birth cohort and calendar period on the observed temporal trends...
2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27266353/-clinical-analysis-of-laparoscopic-surgery-in-patients-with-maintenance-hemodialysis-and-colon-cancer
#17
D X Chen, X A Zhan, Q S Guo, X F Zhou, X J Xu
OBJECTIVE: To explore the safety of laparoscopic assisted radical resection of colon cancer in uremic patients. METHODS: Retrospective analysis of Zhejiang Jinhua Guangfu hospital 2012 March to 2015 March 5 cases of uremia patients complicated with colon cancer underwent laparoscopic assisted colorectal cancer radical resection, and compared with 10 cases, observing two groups of operative time, intraoperative bleeding volume, postoperative drainage volume, lymph nodes dissect, anal exhaust time, postoperative complications, postoperative hospitalization time and postoperative pathological staging...
May 17, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27241609/colonic-casts-unexpected-complications-of-colonic-ischaemia
#18
D Mantas, C Damaskos, G Bamias, D Dimitroulis
Introduction Extensive colonic ischaemia can result in passage of a colonic 'cast' (CC) through the rectum. Case Study We report a 69-year-old male who initially underwent surgery to remove a sessile polyp. On postoperative day (POD)15, he was febrile, suffering from diarrhoea, and was treated conservatively. On POD18, the patient returned to our hospital with a CC that presented after defaecation. Computed tomography of the abdomen revealed a CC extending from the descending colon to the anal orifice with presentation of air between the affected colonic wall and the CC...
September 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27144002/colonic-polyposis-in-a-15-year-old-boy-challenges-and-lessons-from-a-rural-resource-poor-area
#19
Nasser Kakembo, Phyllis Kisa, Tamara Fitzgerald, Doruk Ozgediz, John Sekabira
INTRODUCTION: Colorectal polyps usually present with rectal bleeding and are associated with increased risk of colorectal carcinoma. Evaluation and management in resource-poor areas present unique challenges. PRESENTATION OF CASE: This 15 year-old boy presented with 9 years of painless rectal bleeding and 2 years of a prolapsing rectal mass after passing stool. He had 3 nephews with similar symptoms. On clinical assessment and initial exam under anesthesia, an impression of a polyposis syndrome was made and a biopsy taken from the mass that revealed inflammatory polyps with no dysplasia...
May 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27025236/use-of-the-circular-compression-stapler-and-circular-mechanical-stapler-in-the-end-to-side-transanal-colorectal-anastomosis-after-left-colon-and-rectal-resections-a-single-center-experience
#20
Daniele Pironi, Maurizio Vendettuoli, Stefano Pontone, Alessandra Panarese, Stefano Arcieri, Angelo Filippini, Gianmarco Grimaldi
AIM: The aim of our study was to compare the efficacy of the circular compression stapler and the circular mechanical stapler in transanal colorectal anastomosis after left colectomy or anterior rectal resection. MATERIALS AND METHODS: We performed a retrospective analysis of 10 patients with disease of the, sigmoid colon or rectum (carcinoma or diverticular disease) who underwent left colectomy or anterior rectal resection with end-to-side transanal colorectal anastomosis...
2016: Annali Italiani di Chirurgia
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