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https://www.readbyqxmd.com/read/28336569/cued-memory-retrieval-exhibits-reinstatement-of-high-gamma-power-on-a-faster-timescale-in-the-left-temporal-lobe-and-prefrontal-cortex
#1
Robert B Yaffe, Ammar Shaikhouni, Jennifer Arai, Sara K Inati, Kareem A Zaghloul
Converging evidence suggests that reinstatement of neural activity underlies our ability to successfully retrieve memories. However, the temporal dynamics of reinstatement in the human cortex remain poorly understood. One possibility is that neural activity during memory retrieval, like replay of spiking neurons in the hippocampus, occurs at a faster timescale than during encoding. We tested this hypothesis in 34 participants who performed a verbal episodic memory task while we recorded high gamma (62-100 Hz) activity from subdural electrodes implanted for seizure monitoring...
March 23, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28335695/impact-of-cognition-and-noise-reduction-on-speech-perception-in-adults-with-unilateral-cochlear-implants
#2
Suzanne Carolyn Purdy, David Welch, Ellen Giles, Catherine Louise Anne Morgan, Renique Tenhagen, Abin Kuruvilla-Mathew
OBJECTIVES: The purpose of this study was to investigate the impact of cognition and noise reduction (NR) technology in cochlear implants (CIs) on speech perception and listening effort. METHODS: Thirteen adults fitted with unilateral CIs (Nucleus(®) 6, CP900) participated in this study. Participants performed: (I) cognitive tests of working memory and processing speed, (II) speech perception in noise tests, and (III) an auditory-visual dual-task paradigm to quantify listening effort, as a part of the three-phase experimental study...
March 24, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28335018/dissecting-gamma-frequency-activity-during-human-memory-processing
#3
Michal T Kucewicz, Brent M Berry, Vaclav Kremen, Benjamin H Brinkmann, Michael R Sperling, Barbara C Jobst, Robert E Gross, Bradley Lega, Sameer A Sheth, Joel M Stein, Sandthitsu R Das, Richard Gorniak, S Matthew Stead, Daniel S Rizzuto, Michael J Kahana, Gregory A Worrell
Gamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not clear, however, which processes contribute to human brain gamma frequency activity, or their dynamics and roles during memory processing...
March 13, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28333145/the-cryo-thermal-therapy-eradicated-melanoma-in-mice-by-eliciting-cd4-t-cell-mediated-antitumor-memory-immune-response
#4
Kun He, Ping Liu, Lisa X Xu
Tumor metastasis is a major concern in tumor therapy. In our previous studies, a novel tumor therapeutic modality of the cryo-thermal therapy has been presented, highlighting its effect on the suppression of distal metastasis and leading to long-term survival in 4T1 murine mammary carcinoma model. To demonstrate the therapeutic efficacy in other aggressive tumor models and further investigate the mechanism of long-term survival induced, in this study, spontaneous metastatic murine B16F10 melanoma model was used...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28306221/construction-of-small-diameter-vascular-graft-by-shape-memory-and-self-rolling-bacterial-cellulose-membrane
#5
Ying Li, Kai Jiang, Jian Feng, Jinzhe Liu, Rong Huang, Zhaojun Chen, Junchuan Yang, Zhaohe Dai, Yong Chen, Nuoxin Wang, Wenjin Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial cellulose (BC) membranes with shape-memory properties allow the rapid preparation of artificial small-diameter blood vessels when combined with microfluidics-based patterning with multiple types of cells. Lyophilization of a wet multilayered rolled BC tube endows it with memory to recover its tubular shape after unrolling. The unrolling of the BC tube yields a flat membrane, and subsequent patterning with endothelial cells, smooth muscle cells, and fibroblast cells is carried out by microfluidics...
March 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28296559/the-irony-of-highly-effective-bacterial-therapy-of-a-patient-derived-orthotopic-xenograft-pdox-model-of-ewing-s-sarcoma-which-was-blocked-by-ewing-himself-80%C3%A2-years-ago
#6
Takashi Murakami, Tasuku Kiyuna, Kei Kawaguchi, Kentaro Igarashi, Arun S Singh, Yukihiko Hiroshima, Yong Zhang, Ming Zhao, Kentaro Miyake, Scott D Nelson, Sarah M Dry, Yunfeng Li, Jonathan C DeLong, Thinzar M Lwin, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Fritz C Eilber, Robert M Hoffman
William B. Coley developed bacterial therapy of cancer more than 100 years ago and had clinical success. James Ewing, a very famous cancer pathologist for whom the Ewing sarcoma is named, was Coley's boss at Memorial Hospital in New York and terminated Coley's bacterial therapy of cancer. A tumor from a patient with soft-tissue Ewing's sarcoma, who failed doxorubicin (DOX) therapy, was previously implanted in nude mice to establish a patient-derived orthotopic xenograft (PDOX) model. In the present study, the Ewing's sarcoma PDOX was treated with tumor-targeting S...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28287814/activation-and-deactivation-of-5-ht1-receptor-of-accumbens-shell-area-does-not-alter-acpa-induced-aversive-memory-deficit-in-male-rat
#7
Marzieh Keramati-Nojedehsadat, Shahrbanoo Oryan, Mohammad Reza Zarrindast, Vahab Babapour
BACKGROUND: Some studies have indicated a close relation between serotonergic and cannabinoidergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male Wistar rats. METHOD: Bilateral guide cannulae were implanted to allow microinjection of ACPA, CP94253 HCL (5-HT1 receptor agonist agonist) or GR127935 HCL (5-HT1 receptor antagonist)...
March 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28283757/concept-of-patient-specific-shape-memory-implants-for-the-treatment-of-orbital-floor-fractures
#8
Ronny Grunert, Maximilian Wagner, Christian Rotsch, Harald Essig, Susanna Posern, Friedemann Pabst, Welf-Guntram Drossel, Juergen Lichtenstein
PURPOSE: We will aim to develop implants made of a Ni-Ti shape memory alloy which can be applied for the treatment of midface fractures, such as isolated orbital floor fractures. These can then be implanted in a compressed form and unfold automatically in the body. With the help of newly developed application instruments, the implants can be applied along transnasal and transantral approaches into the maxillary sinus. Our objective is to evaluate the operation process and the functionality of these implants, already in a pre-investigation by an experienced surgeon on a phantom...
March 10, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28277213/the-effect-of-learning-modality-and-auditory-feedback-on-word-memory-cochlear-implanted-versus-normal-hearing-adults
#9
Riki Taitelbaum-Swead, Michal Icht, Yaniv Mama
BACKGROUND: In recent years, the effect of cognitive abilities on the achievements of cochlear implant (CI) users has been evaluated. Some studies have suggested that gaps between CI users and normal-hearing (NH) peers in cognitive tasks are modality specific, and occur only in auditory tasks. PURPOSE: The present study focused on the effect of learning modality (auditory, visual) and auditory feedback on word memory in young adults who were prelingually deafened and received CIs before the age of 5 yr, and their NH peers...
March 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28268901/a-flexible-parylene-probe-for-in-vivo-recordings-from-multiple-subregions-of-the-rat-hippocampus
#10
Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song
The hippocampus is crucial to the formation of long-term memory and declarative memory. It is divided into three sub-fields the CA1, the CA3 and the DG. To understand the neuronal circuitry within the hippocampus and to study the role of the hippocampus in memory function requires the collection of neural activities from multiple subregions of the hippocampus simultaneously. Micro-wire electrode arrays are commonly used as an interface with neural systems. However, recording from multiple deep brain regions with curved anatomical structures such as the thin cell body layers of the hippocampus requires the micro-wires to be arranged into a highly accurate, complex layout that is difficult to fabricated manually...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268715/a-32-channel-wireless-system-for-recording-gastric-electrical-activity
#11
Christopher S Springston, Rui Bao, Aydin Farajidavar
This paper presents a wireless system designed to collect, store and transmit gastric electrical activity, known as slow waves. The system is composed of a miniaturized front-end module that can record from up to 32 locations of the stomach, and a back-end module. The front-end could either store the recorded slow waves into a flash memory, or wirelessly transmit them to the back-end connected to a computer featuring a custom-made graphical user interface (GUI). The GUI displays signals in real time, and stores them for off-line analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28259837/shape-memory-polymers-with-enhanced-visibility-for-magnetic-resonance-and-x-ray-imaging-modalities
#12
A C Weems, J M Szafron, A D Easley, S Herting, J Smolen, D J Maitland
Currently, monitoring of minimally invasive medical devices is performed using fluoroscopy. The risks associated with fluoroscopy, including increased risk of cancer, make this method especially unsuitable for pediatric device delivery and follow-up procedures. A more suitable method is magnetic resonance (MR) imaging, which makes use of harmless magnetic fields rather than ionizing radiation when imaging the patient; this method is safer for both the patient and the performing technicians. Unfortunately, there is a lack of research available on bulk polymeric materials to enhance MR-visibility for use in medical devices...
March 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28249730/real-time-changes-in-hippocampal-energy-demands-during-a-spatial-working-memory-task
#13
John Kealy, Rachel Bennett, Barbara Woods, John P Lowry
Activity-dependent changes in hippocampal energy consumption have largely been determined using microdialysis. However, real-time recordings of brain energy consumption can be more accurately achieved using amperometric sensors, allowing for sensitive real-time monitoring of concentration changes. Here, we test the theory that systemic pre-treatment with glucose in rats prevents activity-dependent decreases in hippocampal glucose levels and thus enhances their performance in a spontaneous alternation task. Male Sprague Dawley rats were implanted into the hippocampus with either: 1) microdialysis probe; or 2) an oxygen sensor and glucose biosensor co-implanted together...
February 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28237734/respective-role-of-surface-electrocardiogram-and-his-bundle-recordings-to-assess-the-risk-of-atrioventricular-block-after-transcatheter-aortic-valve-replacement
#14
N Badenco, C Chong-Nguyen, C Maupain, C Himbert, G Duthoit, X Waintraub, T Chastre, E Gandjbakhch, F Hidden-Lucet, P Le Prince, J-P Collet, R Frank
BACKGROUND: Atrioventricular block (AVB) is common after transcatheter aortic valve replacement (TAVR) and permanent pacemaker (PPM) implantation is needed in up to 30% of patients. Main predictors of long term AVB are electrocardiographic. The purpose of this study is to assess the prognostic value of serial HV intervals measured before and after TAVR to shorten the timing of PPM implantation. METHODS: His bundle recordings were performed before (HV1), immediately after TAVR (HV2) and at day 2 for Edwards Sapien (ES) and 5 for Medtronic CoreValve (CV) (HV3)...
February 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28227102/a-flexible-parylene-probe-for-in-vivo-recordings-from-multiple-subregions-of-the-rat-hippocampus
#15
Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song, Huijing Xu, Ahuva Weltman, Min-Chi Hsiao, Kee Scholten, Ellis Meng, Theodore W Berger, Dong Song, Ellis Meng, Dong Song, Min-Chi Hsiao, Theodore W Berger, Ahuva Weltman, Kee Scholten, Huijing Xu
The hippocampus is crucial to the formation of long-term memory and declarative memory. It is divided into three sub-fields the CA1, the CA3 and the DG. To understand the neuronal circuitry within the hippocampus and to study the role of the hippocampus in memory function requires the collection of neural activities from multiple subregions of the hippocampus simultaneously. Micro-wire electrode arrays are commonly used as an interface with neural systems. However, recording from multiple deep brain regions with curved anatomical structures such as the thin cell body layers of the hippocampus requires the micro-wires to be arranged into a highly accurate, complex layout that is difficult to fabricated manually...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226903/a-32-channel-wireless-system-for-recording-gastric-electrical-activity
#16
Christopher S Springston, Rui Bao, Aydin Farajidavar, Christopher S Springston, Rui Bao, Aydin Farajidavar, Christopher S Springston, Aydin Farajidavar, Rui Bao
This paper presents a wireless system designed to collect, store and transmit gastric electrical activity, known as slow waves. The system is composed of a miniaturized front-end module that can record from up to 32 locations of the stomach, and a back-end module. The front-end could either store the recorded slow waves into a flash memory, or wirelessly transmit them to the back-end connected to a computer featuring a custom-made graphical user interface (GUI). The GUI displays signals in real time, and stores them for off-line analysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28204915/-acute-chest-pain-and-new-ecg-changes-in-pacemaker-patients-a%C3%A2-clinical-challenge
#17
Matthias Hoyme, Ralf Surber, P Christian Schulze, Dirk Prochnau
We report the case of a 82-year-old woman who was admitted to our institution with acute chest pain, nausea, and vomiting. Because of atrial fibrillation with intermittent bradycardia, a single-chamber pacemaker was implanted 4 years ago. The initial 12-lead ECG showed atrial fibrillation with a heart rate of 70 bpm, narrow QRS, and T‑wave inversions in the inferolateral leads. Coronary artery disease was excluded by immediate cardiac catheterization. A subsequent ECG three hours later showed a ventricular paced rhythm...
February 15, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28197388/inhibition-of-tumor-growth-and-metastasis-by-emmprin-multiple-antigenic-peptide-map-vaccination-is-mediated-by-immune-modulation
#18
Elina Simanovich, Vera Brod, Maya M Rahat, Ella Drazdov, Miriam Walter, Jivan Shakya, Michal A Rahat
Previously, we have identified a new epitope in EMMPRIN, a multifunctional protein that mediates tumor cell-macrophage interactions and induces both MMP-9 and VEGF. Here, we synthesized this epitope as an octa-branched multiple antigenic peptide (MAP) to vaccinate mice implanted with subcutaneous syngeneic colon (CT26), prostate (TRAMP-C2) or renal (RENCA) cell line carcinomas. Vaccination inhibited, and sometimes regressed, tumor growth in a dose-dependent manner, reaching 94%, 71% and 72% inhibition, respectively, at a 50 μg dose (p < 0...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28195832/four-dimensional-printing-hierarchy-scaffolds-with-highly-biocompatible-smart-polymers-for-tissue-engineering-applications
#19
Shida Miao, Wei Zhu, Nathan J Castro, Jinsong Leng, Lijie Grace Zhang
The objective of this study was to four-dimensional (4D) print novel biomimetic gradient tissue scaffolds with highly biocompatible naturally derived smart polymers. The term "4D printing" refers to the inherent smart shape transformation of fabricated constructs when implanted minimally invasively for seamless and dynamic integration. For this purpose, a series of novel shape memory polymers with excellent biocompatibility and tunable shape changing effects were synthesized and cured in the presence of three-dimensional printed sacrificial molds, which were subsequently dissolved to create controllable and graded porosity within the scaffold...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28193522/intracerebroventricular-injection-of-beta-amyloid-in-mice-is-associated-with-long-term-cognitive-impairment-in-the-modified-hole-board-test
#20
Sebastian Schmid, Bettina Jungwirth, Verena Gehlert, Manfred Blobner, Gerhard Schneider, Stephan Kratzer, Kristine Kellermann, Gerhard Rammes
BACKGROUND: The intracerebroventricular injection of beta-amyloid (Aβ) in mice allows the investigation of acute effects on cognitive function and cellular pathology. The aim of this investigation was to further characterize the time course of Aβ-induced cognitive and behavioural changes and to detect potential molecular mechanisms. METHODS: Cannulas were implanted in the lateral cerebral ventricle. 14days after surgery the mice were injected with Aβ1-42 or phosphate buffered saline (PBS)...
May 1, 2017: Behavioural Brain Research
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