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https://www.readbyqxmd.com/read/29791768/vaccine-immunotherapy-with-arnax-induces-tumor-specific-memory-t-cells-and-durable-anti-tumor-immunity-in-mouse-models
#1
Yohei Takeda, Sumito Yoshida, Ken Takashima, Noriko Ishii-Mugikura, Hiroaki Shime, Tsukasa Seya, Misako Matsumoto
Immunological checkpoint blockade therapies benefit a limited population of cancer patients. We have previously shown that vaccine immunotherapy with TLR3-adjuvant and tumor antigen overcomes anti-programmed death ligand-1 (PD-L1) resistance in mouse tumor models. In this study, four different OVA-expressing tumor cell lines were implanted into syngeneic mice and subjected to antitumor immunotherapy using ARNAX and whole OVA protein. ARNAX is a Toll-like receptor 3-specific agonist that does not activate the MAVS pathway, and thus does not induce systemic inflammation...
May 23, 2018: Cancer Science
https://www.readbyqxmd.com/read/29791138/a-three-dimensional-printed-poly-vinyl-alcohol-substrate-with-controlled-on-demand-degradation-for-transient-electronics
#2
Jinsu Yoon, Jungmin Han, Bongsik Choi, Yongwoo Lee, Yeamin Kim, Jinhee Park, Meehyun Lim, Min-Ho Kang, Dae Hwan Kim, Dong Myong Kim, Sungho Kim, Sung-Jin Choi
Electronics that degrade after stable operation for a desired operating time, called transient electrons, are of great interest in many fields, including biomedical implants, secure memory devices, and environmental sensors. Thus, the development of transient materials is critical for the advancement of transient electronics and their applications. However, previous reports have mostly relied on achieving transience in aqueous solutions where the transience time is largely pre-determined based on the materials initially selected at the beginning of fabrication...
May 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29784482/role-of-surface-electrocardiograms-in-patients-with-cardiac-implantable-electronic-devices
#3
REVIEW
Emanuela T Locati, Giuseppe Bagliani, Alessio Testoni, Maurizio Lunati, Luigi Padeletti
Surface electrocardiograms, both resting 12-lead electrocardiographs and ambulatory electrocardiograph monitoring, play an essential role in establishing indications for cardiac implantable electronic devices (pacemakers, cardiac implantable defibrillators, and cardiac resynchronization therapies), and in the evaluation of patients already implanted. Current devices have prolonged memory capabilities (defined as Holter functions) and remote monitoring functions, to evaluate the electrical properties and the automatic detection of arrhythmias...
June 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29780967/visual-working-memory-span-in-adults-with-cochlear-implants-some-preliminary-findings
#4
Aaron C Moberly, David B Pisoni, Michael S Harris
Objective: Neurocognitive functions, specifically verbal working memory (WM), contribute to speech recognition in postlingual adults with cochlear implants (CIs) and normal-hearing (NH) listener shearing degraded speech. Three hypotheses were tested: (1) WM accuracy as assessed using three visual span measures - digits, objects, and symbols - would correlate with recognition scores for spectrally degraded speech (through a CI or when noise-vocoded); (2) WM accuracy would be best for digit span, intermediate for object span, and lowest for symbol span, due to the increasing cognitive demands across these tasks...
December 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29775630/the-basolateral-amygdala-dopaminergic-system-contributes-to-the-improving-effect-of-nicotine-on-stress-induced-memory-impairment-in-rats
#5
Elnaz Keshavarzian, Zahra Ghasemzadeh, Ameneh Rezayof
Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneous (s.c.) administration of nicotine on memory formation under stress and 2) to assess the possible role of the basolateral amygdala (BLA) dopamine D1 and D2 receptors in the effect of nicotine on stress-induced memory retrieval impairment...
May 15, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29761565/cooling-triggered-shapeshifting-hydrogels-with-multi-shape-memory-performance
#6
Xiaobo Hu, Daixuan Zhang, Sergei S Sheiko
Heating-triggered shape actuation is vital for biomedical applications. The likely overheating and subsequent damage of surrounding tissue, however, severely limit its utilization in vivo. Herein, cooling-triggered shapeshifting is achieved by designing dual-network hydrogels that integrate a permanent network for elastic energy storage and a reversible network of hydrophobic crosslinks for "freezing" temporary shapes when heated. Upon cooling to 10 °C, the hydrophobic interactions weaken and allow recovery of the original shape, and thus programmable shape alterations...
May 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29761552/analysis-of-the-bipolar-resistive-switching-behavior-of-a-biocompatible-glucose-film-for-resistive-random-access-memory
#7
Sung Pyo Park, Young Jun Tak, Hee Jun Kim, Jin Hyeok Lee, Hyukjoon Yoo, Hyun Jae Kim
Resistive random access memory (RRAM) devices are fabricated through a simple solution process using glucose, which is a natural biomaterial for the switching layer of RRAM. The fabricated glucose-based RRAM device shows nonvolatile bipolar resistive switching behavior, with a switching window of 103 . In addition, the endurance and data retention capability of glucose-based RRAM exhibit stable characteristics up to 100 consecutive cycles and 104 s under constant voltage stress at 0.3 V. The interface between the top electrode and the glucose film is carefully investigated to demonstrate the bipolar switching mechanism of the glucose-based RRAM device...
May 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29741115/the-role-of-biomaterials-in-implantation-for-central-nervous-system-injury
#8
Yu-Shuan Chen, Horng-Jyh Harn, Tzyy-Wen Chiou
Permanent deficits that occur in memory, sensation, and cognition can result from central nervous system (CNS) trauma that causes dysfunction and/or unregulated CNS regeneration. Some therapeutic approaches are preferentially applied to the human body. Therefore, cell transplantation, one of the therapeutic strategies, may be used to benefit people. However, poor cell viability and low efficacy are the limitations to cell transplantation strategies. Biomaterials have been widely used in several fields (e.g...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29731788/the-first-case-of-the-reveal-linq%C3%A2-insertable-cardiac-monitor-implanted-in-a-child-in-malta
#9
A Aquilina, O Aquilina, M Sammut, V Grech
Background: The Reveal LINQ™Insertable Cardiac Monitor (ICM) or Implantable Loop recorder (ILR), is a miniaturized, subcutaneous, single lead, electrocardiographic monitoring device which has been extensively used in the differential diagnosis of unexplained syncope and palpitations in adults. Patient Description: We describe an asymptomatic 20-month-old boy, noted to have incidental bradycardia on routine examination and in whom Holter monitoring revealed complete heart block (CHB)...
October 2017: Images in Paediatric Cardiology
https://www.readbyqxmd.com/read/29728186/passive-sentence-comprehension-difficulties-and-its-related-factors-in-children-with-cochlear-implants
#10
Youngmee Lee, Jee Eun Sung, Hyunsub Sim
OBJECTIVES: The purposes of this study were to investigate which syntactic structures, from active and passive sentences, sensitively differentiate children with cochlear implants (CIs) from children with normal hearing (NH), to explore the correlations among working memory (WM) and other factors for each group, and to examine predictors of the active and passive sentence scores for both groups. METHODS: Twenty deaf children with CIs and 20 children with NH, aged 8-14 years, were included in this study...
June 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29719382/can-cochlear-implantation-improve-neurocognition-in-the-aging-population
#11
Christiane Völter, Lisa Götze, Stefan Dazert, Michael Falkenstein, Jan Peter Thomas
Introduction: The relationship between cognition and the ability to hear is well known. Due to changes in demographics, the number of people with sensorineural hearing loss and cognitive impairment is increasing. The aim of this study was to identify the impact of hearing rehabilitation via cochlear implantation on cognitive decline among the aging population. Patients and methods: This prospective study included 60 subjects aged between 50 and 84 years (mean 65...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29708567/relationship-of-blood-metal-ion-levels-and-leukocyte-profiles-in-patients-with-articular-surface-replacement-metal-on-metal-hip-replacement
#12
David C Markel, Christopher Bergum, Jeffrey Flynn, Nancy Jackson, Therese Bou-Akl, Weiping Ren
The purpose of this study was to compare blood leukocyte profiles and metal ion concentrations between hip resurfacing arthroplasty (articular surface replacement) patients with and without revision. A total of 25 articular surface replacement patients were recruited (10 with stable implants and 15 undergoing revision). Blood concentrations of chromium (Cr) and cobalt (Co) were measured. Flow cytometry was used to quantify the subpopulations of leukocytes, including CD14+ monocytes, CD16+ monocytes, CD3+ T-lymphocytes, CD19+ B-lymphocytes, CD4+ helper T-cells, and CD45+ RA memory vs naïve T-cells...
April 27, 2018: Orthopedics
https://www.readbyqxmd.com/read/29705082/transvenous-extraction-of-advisory-implantable-cardioverter-defibrillator-leads-with-a-relatively-long-implant-duration
#13
Masahiko Goya, Michio Nagashima, Ken-Ichi Hiroshima, Kentaro Hayashi, Yu Makihara, Masato Fukunaga, Yoshimori An, Masatsugu Ohe, Takeshi Sasaki, Shinya Shiohira, Yasuhiro Shirai, Mihoko Kawabata, Kenji Ando, Mitsuaki Isobe, Kenzo Hirao
BACKGROUND: Optimal management of advisory implantable cardioverter defibrillator (ICD) leads has not been established. Several studies were reported concerning the lead extraction of advisory ICD leads, but the implant duration of those studies was short. We estimated the efficacy of lead extractions of advisory ICD leads with a relatively longer duration in Japanese patients. METHODS: We retrospectively analyzed 28 patients who underwent a lead extraction at Kokura Memorial Hospital and Tokyo Medical and Dental University Hospital [Fidelis (Medtronic, Minneapolis, MN, USA): n=19, Riata (St...
April 25, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29704312/self-expandable-tubular-collagen-implants
#14
Luuk R M Versteegden, Marja Ter Meer, Roger M L M Lomme, J Adam van der Vliet, Leo J Schultze Kool, Toin H van Kuppevelt, Willeke F Daamen
Collagen has been extensively used as a biomaterial, yet for tubular organ repair synthetic polymers or metals (e.g. stents) are typically used. In this study we report a novel type of tubular implant solely consisting of type I collagen, suitable to self-expand in case of minimal invasive implantation. Potential benefits of this collagen scaffold over conventional materials include improved endothelialization, biodegradation over time and possibilities to add bioactive components to the scaffold, such as anti-coagulants...
April 28, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29703901/cvd-grown-monolayer-mos-2-in-bioabsorbable-electronics-and-biosensors
#15
Xiang Chen, Yong Ju Park, Minpyo Kang, Seung-Kyun Kang, Jahyun Koo, Sachin M Shinde, Jiho Shin, Seunghyun Jeon, Gayoung Park, Ying Yan, Matthew R MacEwan, Wilson Z Ray, Kyung-Mi Lee, John A Rogers, Jong-Hyun Ahn
Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS2 , including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models...
April 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29702445/insulin-treatment-partially-prevents-cognitive-and-hippocampal-alterations-as-well-as-glucocorticoid-dysregulation-in-early-onset-insulin-deficient-diabetic-rats
#16
Nathalie Marissal-Arvy, Marie-Neige Campas, Audrey Semont, Céline Ducroix-Crepy, Marie-Christine Beauvieux, Julie Brossaud, Jean-Benoit Corcuff, Jean-Christophe Helbling, Sylvie Vancassel, Anne-Karine Bouzier-Sore, Katia Touyarot, Guillaume Ferreira, Pascal Barat, Marie-Pierre Moisan
The diagnosis of Type 1 Diabetes (T1D) in ever younger children led us to question the impact of insulin deficiency or chronic hyperglycemia on cerebral development and memory performances. Here, we sought abnormalities in these traits in a model of streptozotocin-induced diabetes in juvenile rats treated or not by insulin. We made the assumption that such alterations would be related, at least in part, to excessive glucocorticoid exposition in hippocampal neurons. We have compared 3 groups of juvenile rats: controls, untreated diabetics and insulin-treated diabetics...
April 17, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29690711/-the-application-of-stereo-electroencephalography-guided-radiofrequency-thermocoagulation-in-refractory-temporal-epilepsy
#17
C W Xu, W J Zhou, J J Bai, B Q Zhang, H X Wang, J Ruan, J Li, J L Lin, Y Q Zhang
Objective: To investigate the clinical value of stereo-electroencephalography guided radiofrequency thermos-coagulation (RFTC) in drug resistant temporal epilepsy. Methods: The clinical data of 12 patients with refractory temporal epilepsy who underwent implantation of SEEG electrodes and radiofrequency thermos-coagulation from July 2016 to November 2017 were analysed retrospectively. Results: The mean follow-up time was 6.4±4.6 months after thermos-coagulation, and 10.2±3.5 months after resection. Engel Ⅰa was observed in 9 cases, with Ⅱa, Ⅲa and Ⅳa 1 cases respectively...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29687605/shape-memory-properties-and-enzymatic-degradability-of-poly-%C3%AE%C2%B5-caprolactone-based-polyurethane-urea-containing-phenylalanine-derived-chain-extender
#18
Rong Wang, Fanjun Zhang, Weiwei Lin, Wenkai Liu, Jiehua Li, Feng Luo, Yaning Wang, Hong Tan
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(ε-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29649583/noradrenergic-%C3%AE-receptor-antagonism-in-the-basolateral-amygdala-impairs-reconsolidation-but-not-extinction-of-alcohol-self-administration-intra-bla-propranolol-impairs-reconsolidation-of-alcohol-self-administration
#19
Rose Chesworth, Laura H Corbit
A critical barrier to recovery from alcohol addiction is relapse propensity. Alcohol cues can trigger relapse, and pharmacologically facilitating processes such as extinction, which decreases cue associations, may help prevent relapse. The noradrenergic system mediates extinction learning for alcohol; however, the neural locus of this effect is unknown. This study sought to determine whether the basolateral amygdala (BLA), a region critical for fear extinction, also mediates extinction of alcohol seeking. Hooded Wistar rats (N = 12-15 per experiment) were implanted with bilateral cannula targeting the BLA and trained to lever press for 10% ethanol during auditory or visual cues...
April 9, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29623942/combined-acupuncture-and-huangdisan-treatment-affects-behavior-and-synaptophysin-levels-in-the-hippocampus-of-senescence-accelerated-mouse-prone-8-after-neural-stem-cell-transplantation
#20
Chun-Lei Zhou, Lan Zhao, Hui-Yan Shi, Jian-Wei Liu, Jiang-Wei Shi, Bo-Hong Kan, Zhen Li, Jian-Chun Yu, Jing-Xian Han
Sanjiao acupuncture and HuangDiSan can promote the proliferation, migration and differentiation of exogenous neural stem cells in senescence-accelerated mouse prone 8 (SAMP8) mice and can improve learning and memory impairment and behavioral function in dementia-model mice. Thus, we sought to determine whether Sanjiao acupuncture and HuangDiSan can elevate the effect of neural stem cell transplantation in Alzheimer's disease model mice. Sanjiao acupuncture was used to stimulate Danzhong (CV17), Zhongwan (CV12), Qihai (CV6), bilateral Xuehai (SP10) and bilateral Zusanli (ST36) 15 days before and after implantation of neural stem cells (5 × 105 ) into the hippocampal dentate gyrus of SAMP8 mice...
March 2018: Neural Regeneration Research
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