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https://www.readbyqxmd.com/read/29053979/associations-between-use-of-mood-stabilizers-and-risk-of-cataract-a-population-based-nested-case-control-study
#1
Che-Sheng Chu, Ching-Heng Lin, Tsuo-Hung Lan, Po-Han Chou
BACKGROUND: The aim of this study was to investigate whether use of mood stabilizers (MS) is associated with an increased risk of cataract development. METHODS: We conducted a nested case-control study using National Health Insurance Research Database in Taiwan. A total of 14,288 patients with bipolar disorder (BD) and schizophrenia were included; 7651 in the cataract group and 6637 in the control group. Based on overall cumulative period of MS (lithium, carbamazepine, valproate, and lamotrigine) treatment, we categorized into following groups: no use, and duration < 1 year, 1 to 2 years, and > 2 years...
October 5, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29050348/imatinib-dose-escalation-versus-sunitinib-as-a-second-line-treatment-against-advanced-gastrointestinal-stromal-tumors-a-nationwide-population-based-cohort-study
#2
Jun-Te Hsu, Puo-Hsien Le, Chang-Fu Kuo, Meng-Jiun Chiou, Chia-Jung Kuo, Tsung-Hsing Chen, Chun-Jung Lin, Jen-Shi Chen, Huang-Pin Yu, Chun-Nan Yeh, Yi-Yin Jan, Ta-Sen Yeh
BACKGROUND: Although treatment with imatinib in advanced gastrointestinal stromal tumor (GIST) patients has led to significant clinical benefits, the disease will eventually progress due to imatinib resistance. Treatment options after failure of first-line imatinib include imatinib dose escalation or shifting to sunitinib. However, there is no large-scale study to compare the efficacy difference between these two treatment strategies or the role of surgery. RESULTS: This study recruited 521 advanced GIST patients including 246, 125, and 150 placed in groups 1, 2, and 3, respectively...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049319/clinical-outcome-and-prognostic-factors-associated-with-invasive-pulmonary-aspergillosis-an-11-year-follow-up-report-from-taiwan
#3
Kuo-Shao Sun, Ching-Fang Tsai, Solomon Chih-Cheng Chen, Wan-Chun Huang
BACKGROUND: Invasive pulmonary aspergillosis (IPA) has high mortality rate but prognostic factors are not well established. The aim of our study was to evaluate the trend in in-hospital mortality over a period of 11 years and identify factors affecting the clinical outcomes of patients with IPA. METHOD: We conducted a nationwide inpatient population study using data from the Taiwan National Health Insurance Research Database. A total of 407 IPA patients from 2002 to 2012 were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/29049192/effect-of-alcohol-intoxication-on-the-risk-of-venous-thromboembolism-a-nationwide-retrospective-cohort-study
#4
Chih-Jung Shen, Chia-Hung Kao, Tai-Yi Hsu, Chih-Yu Chen, Cheng-Li Lin, Hong-Mo Shih
This study investigated whether alcohol intoxication (AI) increases the risk of venous thromboembolism (VTE) by using the Taiwan National Health Insurance Research Database (NHIRD).Using data from the NHIRD, we assembled 61,229 patients with acute AI and randomly selected 244,916 controls. Each patient was monitored from 2000 to 2011 to identify those who were subsequently diagnosed with deep vein thrombosis (DVT) and pulmonary embolism (PE). Cox proportional hazard regression analysis was conducted to determine the risk of VTE in the patients with AI compared with the controls...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048544/valproic-acid-attenuates-the-risk-of-acute-respiratory-failure-in-patients-with-subarachnoid-hemorrhage
#5
Wen-I Liao, Wu-Chien Chien, Chi-Hsiang Chung, Jen-Chun Wang, Tzu-Tsao Chung, Shi-Jye Chu, Shih-Hung Tsai
Background: To determine whether the use of valproic acid (VPA) is associated with a decreased risk of acute respiratory failure (ARF) in patients with subarachnoid hemorrhage (SAH). Methods: The Taiwan National Health Insurance Research Database was used to analyze all patients newly diagnosed with SAH from 2000 to 2010. The VPA users were matched for age, gender and index date in 1:2 ratios with randomly selected non-VPA users as a comparison group. Multivariate Cox regression was used to identify the predictors of ARF and to compare the incidence rates of ARF among SAH patients using and not using VPA...
October 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29045621/using-proton-pump-inhibitors-correlates-with-an-increased-risk-of-chronic-kidney-disease-a-nationwide-database-derived-case-controlled-study
#6
Shih-Chang Hung, Kuan-Fu Liao, Hung-Chang Hung, Cheng-Li Lin, Shih-Wei Lai, Po-Chang Lee, Shih-Rong Hung
Background: Those taking proton pump inhibitors (PPIs) might have a higher risk of acute kidney injury. The long-term safety, especially the PPI-associated chronic kidney disease (CKD) is the subsequent concern. Objective: This study explores the potential relationship between using PPIs and CKD in Taiwan. Methods: Using a database collated by the Taiwan National Health Insurance programme, we conducted a population-based case-controlled study to identify 16 704 cases of patients aged 20 years or older with newly diagnosed CKD between 2000 and 2013...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29042385/association-between-malignancies-and-marfan-syndrome-a-population-based-nested-case-control-study-in-taiwan
#7
Chin-Wang Hsu, Jen-Chun Wang, Wen-I Liao, Wu-Chien Chien, Chi-Hsiang Chung, Chang-Huei Tsao, Yung-Fu Wu, Min-Tser Liao, Shih-Hung Tsai
OBJECTIVE: Marfan syndrome (MFS) involves a deficiency of the structural extracellular matrix component fibrillin-1 and overactivation of the transforming growth factor-β (TGF-β) signalling pathway. The TGF-β signalling pathway also actively participates in malignant transformation. Although anecdotal case reports have suggested associations between MFS/MFS-like conditions and several haematological and solid malignancies, such associations have not been thoroughly evaluated in large-scale studies...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29037552/the-impact-of-prenatal-group-b-streptococcus-screening-as-a-national-health-policy-in-taiwan
#8
Fung-Wei Chang, Chun-I Lee, Hueng-Chuen Fan, Her-Young Su, Yung-Liang Liu, Cheng-Yu Chen
OBJECTIVE: There was no national data on group B streptococcus (GBS) infections in Taiwan. Until 2012, when prenatal GBS screening was introduced to obstetric practices as a national health policy aimed at reducing neonatal GBS infections. The purpose of this study was to examine the impact of this national health policy on the incidence of maternal GBS colonization and neonatal GBS infection rate. Relatedly, the clinical characteristics of neonatal GBS infection were investigated to determine the correlations between the incidence of maternal GBS colonization and the neonatal GBS infection rate...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29036872/factors-influencing-the-occupational-injuries-of-physical-therapists-in-taiwan-a-hierarchical-linear-model-approach
#9
Yu-Hui Tao, Yu-Lung Wu, Wan-Yun Huang
BACKGROUND: The evidence literature suggests that physical therapy practitioners are subjected to a high probability of acquiring work-related injuries, but only a few studies have specifically investigated Taiwanese physical therapy practitioners. OBJECTIVE: This study was conducted to determine the relationships among individual and group hospital-level factors that contribute to the medical expenses for the occupational injuries of physical therapy practitioners in Taiwan...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036295/psychotropic-medications-prescribing-trends-in-adolescents-a-nationwide-population-based-study-in-taiwan
#10
Chin-Yen Tsai, Hsuan-Chia Yang, Mohaimenul Islam, Wan-Shan Hsieh, Shing-Hwa Juan, Jiang-Chen Chen, Hafsah Arshed Ali Khan, Wen-Shan Jian
Objective: To describe psychotropic medications prescription patterns among adolescents in Taiwan; focusing on age, gender, duration of treatments and various classes of psychotropic medications. Design: A retrospective description analysis. Setting: Taiwan National Health Insurance Database. Participants: Twelve to seventeen years' patients treated with psychotropic medications. Intervention: None...
September 20, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29032572/effect-of-enterovirus-infections-on-asthma-in-young-children-a-national-cohort-study
#11
Jun-Jun Yeh, Cheng-Li Lin, Wu-Huei Hsu
BACKGROUND: We conducted a cohort study to determine the relationship between enterovirus (EV) infection and asthma. MATERIALS AND METHODS: From the National Health Insurance Research Database of Taiwan, we identified patients who received a new diagnosis of asthma and concurrent treatment between January 2000 and December 2011 (EV cohort: n = 208,213; non-EV cohort: n = 208,213). Cox proportional hazards regression analysis was performed to determine and compare the adjusted hazard ratios (aHRs) of asthma between these 2 cohorts...
October 15, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29032384/proton-pump-inhibitor-use-and-the-risk-of-osteoporosis-and-fracture-in-stroke-patients-a-population-based-cohort-study
#12
S-M Lin, S-H Yang, C-C Liang, H-K Huang
A considerable proportion of stroke survivors are prescribed with proton pump inhibitors (PPIs). Our study indicated that PPI use is associated with an increased risk of osteoporosis, hip fracture, and vertebral fracture in stroke patients. The risk tends to increase as the cumulative doses of PPIs increase. INTRODUCTION: A considerable proportion of stroke survivors are prescribed with proton pump inhibitors (PPIs). Our study investigated the association between PPI use and the risk of osteoporosis and fracture among stroke survivors...
October 14, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29029334/effect-of-long-term-hydroxychloroquine-on-vascular-events-in-patients-with-systemic-lupus-erythematosus-a-database-prospective-cohort-study
#13
Chung-Yuan Hsu, Yu-Sheng Lin, Yu-Jih Su, Hsing-Fen Lin, Ming-Shyan Lin, Ya-Jhu Syu, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Tien-Hsing Chen
Objectives: The incidence of thromboembolism in patients with SLE is higher than that in the general population. HCQ, widely used to treat lupus, may have vascular protective effects. The aim of this study was to determine whether long-term HCQ exposure is associated with decreased thromboembolism risk in SLE. Methods: We designed a prospective cohort study within an SLE population based on the National Health Insurance Research Database in Taiwan. We divided participants into HCQ and control groups according to HCQ prescription during the first year...
September 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/29028676/air-pollution-as-a-potential-determinant-of-rheumatoid-arthritis-a-population-based-cohort-study-in-taiwan
#14
Chau-Ren Jung, Hui-Ya Hsieh, Bing-Fang Hwang
BACKGROUND: Limited studies have explored the relationship between air pollution and rheumatoid arthritis (RA), with the results being somewhat inconsistent. METHODS: This was a retrospective cohort study that included 322,301 subjects aged 30-50 years, selected from the National Health Insurance Research Database in Taiwan, were followed from 2001 to 2010. We used a time-dependent extended Cox model and incorporated time-dependent variables to estimate the associations between the annual mean concentrations of air pollutants with RA, including carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), particles with an aerodynamic diameter less than 10 μm (PM10), and sulfur dioxide (SO2), and reported the hazard ratio (HR) and 95% confidence interval (CI)...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028675/the-risk-of-stroke-in-physicians-a-population-based-cohort-study-in-taiwan
#15
Hon-Pheng Tam, Hung-Jung Lin, Shih-Feng Weng, Chien-Chin Hsu, Jhi-Joung Wang, Shih-Bin Su, Chien-Cheng Huang, How-Ran Guo
BACKGROUND: Physicians in Taiwan work in stressful workplaces and have heavy workloads, both of which may contribute to the occurrence of a stroke. However, it is not clear whether they have a higher risk of stroke. Therefore, we conducted a population-based cohort study to compare the risks of stroke between physicians and the general population and among subgroups of physicians in Taiwan. METHODS: In the National Health Insurance Research Database of Taiwan, we identified 28,062 physicians and selected 84,186 age- and sex-matched nonmedical staff beneficiaries as the references...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29020377/the-effect-of-a-hepatitis-pay-for-performance-program-on-outcomes-of-patients-undergoing-antiviral-therapy
#16
Tsung-Tai Chen, Ya-Seng Arthur Hsueh, Chun-Hsiung Ko, Ling-Na Shih, Sien-Sing Yang
Background: To examine the effect of a participatory pay-for-performance (P4P) program in Taiwan on health outcomes for patients with severe hepatitis B or C. Methods: This study adopted 4-year panel data from the databases of the National Health Insurance Administration (NHIA) in Taiwan. Using the caliper matching method to match patients in the P4P (experimental) group with those in the potential comparison group on a one-to-one basis for the year 2010, we tracked patients up to the year 2013 and employed Cox proportional-hazards regression models to evaluate the effect on patient outcomes...
August 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29019947/trends-and-comparisons-of-utilization-of-emergency-departments-due-to-traumatic-or-non-traumatic-causes-among-the-hiv-positive-population-in-taiwan-2006-2011
#17
Ching-Heng Lin, Ting Lin, Pesus Chou, Nan-Ping Yang
It is important that the utilization of emergency departments (EDs) among people living with the human immunodeficiency virus (HIV) be epidemiologically evaluated in order to assess and improve the HIV care continuum. All participants newly-diagnosed with HIV in Taiwan registered in the National Health Insurance Database from 2000 to 2005 were enrolled in this study and followed-up from 2006 to 2011. In total, 3500 participants newly-diagnosed with HIV in 2000-2005 were selected as a fixed-cohort population and followed-up from 2006 to 2011...
October 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29017085/diseases-of-the-pancreas-and-suicide-mortality-a-nationwide-nested-case-control-study-among-patients-with-mental-health-disorders-in-taiwan
#18
Hong-Ming Chen, Vincent Chin-Hung Chen, Tsu-Nai Wang, Mong-Liang Lu, Yin-Cheng Huang, Michael E Dewey, Johnny Kuang-Wu Lee, Ching-Piao Tsai
OBJECTIVE: Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study. METHODS: The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010...
September 29, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28994901/risk-of-first-onset-stroke-in-ssri-exposed-adult-subjects-survival-analysis-and-examination-of-age-and-time-effects
#19
Chin-Hong Chan, Hsiang-Hsiung Huang, Ching-Heng Lin, Yi-Chun Kuan, El-Wui Loh, Tsuo-Hung Lan
OBJECTIVE: Exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to increase the risk of stroke. In this study, we investigated age and time effects on the risk of first onset stroke in SSRI-exposed (SSRIEXP) adult subjects. METHODS: We analyzed an 8-year cohort from the National Health Insurance Research Database, Taiwan. Patients were defined as SSRIEXP subjects if they received SSRI prescriptions for at least 2 consecutive months during January 1, 2001, to December 31, 2007...
September 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28993387/risk-and-adverse-outcomes-of-fractures-in-patients-with-liver-cirrhosis-two-nationwide-retrospective-cohort-studies
#20
Ta-Liang Chen, Chao-Shun Lin, Chun-Chuan Shih, Yu-Feng Huang, Chun-Chieh Yeh, Chih-Hsing Wu, Yih-Giun Cherng, Chien-Chang Liao
OBJECTIVE: The aim of this study is to evaluate fracture risk and post-fracture outcomes in patients with and without liver cirrhosis (LC). DESIGN: Retrospective cohort study and nested fracture cohort study. SETTING: This study was based on Taiwan's National Health Insurance Research Database that included information on: (1) 3941 patients aged 20 years and older newly diagnosed with LC between 2000 and 2003; (2) 688290 hospitalised fracture patients aged 20 years and older between 2006 and 2013...
October 8, 2017: BMJ Open
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