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https://www.readbyqxmd.com/read/29648667/epidemiology-risk-factors-and-characteristics-of-pediatric-stroke-a-nationwide-population-based-study
#1
Kuo-Liang Chiang, Chen-Yang Cheng
Background: Stroke, classically characterized as an acute acquired neurological deficit, is an important leading cause of death and chronic morbidity in children. Aims: This study reported the period prevalence, incidence, and risk factors of pediatric stroke in Taiwan. Methods and Procedures: All Taiwan inhabitants aged 1 month to 18 years registered in the National Health Insurance Research Database (NHIRD) between 2010 and 2011 were enrolled in this study...
April 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29624580/estimating-the-response-and-economic-burden-of-rheumatoid-arthritis-patients-treated-with-biologic-disease-modifying-antirheumatic-drugs-in-taiwan-using-the-national-health-insurance-research-database-nhird
#2
Qiang Shi, Ko-Jen Li, Tamas Treuer, Bruce C M Wang, Carol L Gaich, Chien-Hsun Lee, Wen-Shuo Wu, Wesley Furnback, Chao-Hsiun Tang
BACKGROUND: Previous studies in Taiwan utilizing the Taiwan's National Health Insurance Database (NHIRD) have estimated the direct healthcare costs of RA patients, but they have not focused on patients on bDMARDs, or considered patients' response to therapy. OBJECTIVES: The objective of this study was to estimate the rate of inadequate response for patients newly treated with biologic disease-modifying antirheumatic drugs (bDMARDs) as well as their costs and resource use...
2018: PloS One
https://www.readbyqxmd.com/read/29623039/simvastatin-therapy-for-drug-repositioning-to-reduce-the-risk-of-prostate-cancer-mortality-in-patients-with-hyperlipidemia
#3
Yu-An Chen, Ying-Ju Lin, Cheng-Li Lin, Hwai-Jeng Lin, Hua-Shan Wu, Hui-Ying Hsu, Yu-Chen Sun, Hui-Yu Wu, Chih-Ho Lai, Chia-Hung Kao
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in the western world, and the mortality rate from PCa in Asia has been increasing recently. Statins are potent inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase and are commonly used for treating hyperlipidemia, with beneficial effects for cardiovascular disease and they also exhibit anti-cancer activity. However, the protective effects of statins against PCa are controversial. In this study, we investigated the effect of two types of statins (simvastatin and lovastatin) and the mortality rate of PCa patients by using the Taiwan National Health Insurance Research Database (NHIRD)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29622587/efficacy-and-safety-of-apixaban-dabigatran-rivaroxaban-and-warfarin-in-asians-with-nonvalvular-atrial-fibrillation
#4
Yi-Hsin Chan, Lai-Chu See, Hui-Tzu Tu, Yung-Hsin Yeh, Shang-Hung Chang, Lung-Sheng Wu, Hsin-Fu Lee, Chun-Li Wang, Chang-Fu Kuo, Chi-Tai Kuo
BACKGROUND: Whether non-vitamin K antagonist oral anticoagulants (NOACs) are superior to warfarin among Asians with nonvalvular atrial fibrillation remains unclear. METHODS AND RESULTS: In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, there were 5843, 20 079, 27 777, and 19 375 nonvalvular atrial fibrillation patients taking apixaban, dabigatran, rivaroxaban and warfarin, respectively, from June 1, 2012 to December 31, 2016...
April 5, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29621983/single-and-dual-antiplatelet-therapy-in-elderly-patients-of-medically-managed-myocardial-infarction
#5
Ting-Tse Lin, Hsiu-Yun Lai, K Arnold Chan, Yen-Yun Yang, Chao-Lun Lai, Mei-Shu Lai
BACKGROUNDS: To examine the comparative effectiveness between dual and single antiplatelet therapies in real-world, medically managed elderly patients with acute myocardial infarction (AMI). METHODS: This retrospective study identified very elderly (> 85 years) patients, who were medically managed, with their first AMI from the Taiwan National Health Insurance claims database from 2007 to 2010. Patients were classified as dual antiplatelet therapy (DAPT) group, aspirin only group and clopidogrel only group...
April 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29613879/the-relationship-between-nursing-workload-quality-of-care-and-nursing-payment-in-intensive-care-units
#6
Li-Yin Chang, Hsiu-Hui Yu, Yann-Fen C Chao
BACKGROUND: Nursing workload is highly associated with patient safety. It has been argued that the imbalance between nursing payment and nursing workload in Taiwan National Health Insurance (NHI)-covered intensive care units (ICUs) has resulted in the inadequate allocation of nursing manpower. However, limited empirical data are currently available to support this argument. PURPOSE: The aim of this study was to investigate the correlation between nursing workload, quality of care, and NHI-covered nursing payments in ICU settings...
April 3, 2018: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29609841/the-safety-and-risk-factors-of-revision-adenoidectomy-in-children-and-adolescents-a-nationwide-retrospective-population-based-cohort-study
#7
Dai-Lou Lin, Chuan-Song Wu, Chao-Hsiun Tang, Ting-Yu Kuo, Tzong-Yang Tu
OBJECTIVE: To investigate the safety of adenoidectomy and risk factors of re-adenoidectomy, and intend to provide evidence-based information to clinicians for further consideration. METHODS AND MATERIALS: This study was based on data obtained from Taiwan's National Health Insurance Research Database from the period 2002-2011. We utilized that data from the hospitalization group and collected information regarding those individuals who accepted adenoidectomy with or without tonsillectomy and post-adenoidectomy bleeding...
March 30, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29609583/risk-factors-for-neonatal-early-onset-group-b-streptococcus-related-diseases-after-the-implementation-of-a-universal-screening-program-in-taiwan
#8
Li-Chen Hung, Pei-Tseng Kung, Tsan-Hung Chiu, Hsun-Pi Su, Ming Ho, Hui-Fen Kao, Li-Ting Chiu, Kuang-Hua Huang, Wen-Chen Tsai
BACKGROUND: We examined the risk for Group B streptococcus (GBS)-related diseases in newborns born to mothers who participated in a universal GBS screening program and to determine whether differences are observed in factors affecting the morbidity for neonatal early-onset GBS-related diseases. METHODS: This is a retrospective study and the study subjects were women who had undergone GBS screening and who gave birth naturally and their newborns between April 15, 2012 and December 31, 2013...
April 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29606115/number-of-cholangitis-episodes-as-a-prognostic-marker-to-predict-timing-of-liver-transplantation-in-biliary-atresia-patients-after-kasai-portoenterostomy
#9
Szu-Ying Chen, Chieh-Chung Lin, Yu-Tse Tsan, Wei-Cheng Chan, Jiaan-Der Wang, Yi-Jung Chou, Ching-Heng Lin
BACKGROUND: Cholangitis may affect liver failure of biliary atresia (BA) patients after Kasai portoenterostomy (KP). We examined whether the number of cholangitis episodes could be a prognostic marker for liver transplant (LT) in children with BA after Kasai portoenterostomy (KP). METHODS: Data for BA patients born after 1998 and undergoing KP were obtained from National Health Insurance Research Database (NHIRD), Taiwan. Patients were followed up until the end of 2011...
April 2, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29605366/population-based-survey-of-inpatient-pediatric-tonsillectomy-and-postoperative-hemorrhage-in-taiwan-1997-2012
#10
Wan-Yi Hsueh, Wei-Chung Hsu, Jenq-Yuh Ko, Te-Huei Yeh, Chia-Hsuan Lee, Kun-Tai Kang
OBJECTIVE: Tonsil surgery in children is a common surgical procedure, and is mostly performed as an inpatient procedure in Taiwan. This study elucidates the epidemiology and postoperative hemorrhage of inpatient tonsillectomies in Taiwanese children. METHODS: This study used the Taiwan National Health Insurance Research Database for analysis. From 1997 to 2012, all in-hospital children (aged <18 years) who underwent tonsillectomies were identified through the International Codes of Diseases (9th Revision)...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29596539/the-sociocultural-effects-on-orthopedic-surgeries-in-taiwan
#11
Shin-Lin Chiu, Mei-Jih Gee, Chih-Hsin Muo, Chiao-Lee Chu, Shou-Jen Lan, Chiu-Liang Chen
Various sociocultural factors affect healthcare-seeking behaviors. In Taiwanese society, superstitions and lunar festivals play important roles in people's lives. We investigated the impact of "Ghost Month" (the 7th lunar month) and Chinese New Year (the 12th lunar month and the 1st lunar month of the following year) on the number of elective surgeries and emergent surgeries in Taiwan. The number of total knee replacement (TKR) surgeries and proximal femur fracture (PFF) surgeries in each lunar month from 2000 to 2011 were extracted from the Taiwan National Health Insurance Database, a computerized and population-based database...
2018: PloS One
https://www.readbyqxmd.com/read/29587654/antepartum-urinary-tract-infection-and-postpartum-depression-in-taiwan-a-nationwide-population-based-study
#12
Jui-Ming Liu, Feng-Hsiang Chiu, Yueh-Ping Liu, Shu-Pin Chen, Hsun-Hao Chan, Jing-Jung Yang, Fung-Wei Chang, Ren-Jun Hsu
BACKGROUND: Urinary tract infections (UTIs) are among the most common bacterial infections in pregnant women due to anatomic and physiologic changes in the female urinary tract during pregnancy, and antepartum UTIs can cause adverse pregnancy outcomes that may induce mental stress. There have only been a few studies, however, investigating antepartum UTIs and mental stress. As such, the present study was conducted in order to investigate the association between antepartum UTIs and postpartum depression (PPD)...
March 27, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29579127/prognostic-factors-in-epithelial-ovarian-cancer-a-population-based-study
#13
Lin-Chau Chang, Chih-Fen Huang, Mei-Shu Lai, Li-Jiuan Shen, Fe-Lin Lin Wu, Wen-Fang Cheng
The overall survival (OS) of patients with ovarian cancer is poor while epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer. The aim of the present study was to evaluate the clinico-pathologic characteristics, especially the prognostic factors, for patients with epithelial ovarian cancer (EOC) in Taiwan. Information about newly diagnosed patients with EOC from 2009 to 2012 was retrieved from the database of the Taiwan Cancer Registry. Data from 2009 to 2013 for the respective cases from the claims database of Taiwan's National Health Insurance and National Death Registry were then retrieved...
2018: PloS One
https://www.readbyqxmd.com/read/29578954/health-care-costs-and-utilization-of-dabigatran-compared-with-warfarin-for-secondary-stroke-prevention-in-patients-with-nonvalvular-atrial-fibrillation-a-retrospective-population-study
#14
Nai-Fang Chi, Ye Wang, Li-Nien Chien, Shu-Chen Chien, Yu Ko
BACKGROUND: It remains unclear whether the use of new oral anticoagulants, compared with warfarin, is economically beneficial in Asian countries. OBJECTIVE: The objective of this study is to compare the health care costs and utilization between dabigatran and warfarin in a real-world nonvalvular atrial fibrillation (NVAF) population. RESEARCH DESIGN: Data were obtained from the Taiwan National Health Insurance Database, and patients with an NVAF diagnosis between June 1, 2012, and May 31, 2014, were identified using the International Classification of Diseases, Ninth Revision code of 427...
March 23, 2018: Medical Care
https://www.readbyqxmd.com/read/29577672/cancer-risk-in-patients-with-alopecia-areata-a-nationwide-population-based-matched-cohort-study
#15
Chih-Chiang Chen, Yun-Ting Chang, Han-Nan Liu, Yi-Ju Chen
Alopecia areata (AA) is an organ-specific autoimmune disorder. Defective immune system related disorders are prone to increase the risk of cancer formation. However, the association among AA and variety of cancer types had never been studied. A nationwide population-based matched cohort study was conducted to evaluate the cancer risk in patients with AA. Records from Taiwan National Health Insurance Research Database were analyzed. Cases of AA from 1997 to 2013 and cancers registered in the catastrophic illness profile from the same time period were collected...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29572399/risks-of-all-cause-mortality-and-major-kidney-events-in-patients-with-new-onset-primary-open-angle-glaucoma-a-nationwide-long-term-cohort-study-in-taiwan
#16
Chu-Lin Chou, Tsung-Cheng Hsieh, Jin-Shuen Chen, Te-Chao Fang
OBJECTIVE: Cardiovascular risk factors are associated with primary open-angle glaucoma (POAG) in the general population. However, long-term mortality and major kidney events in patients with new-onset POAG remain unclear. METHODS: Using the Taiwan National Health Insurance Research Database between 1997 and 2011, 15 185 patients with a new diagnosis of POAG were enrolled and propensity score matched (1:1) with 15 185 patients without ocular disorders (WODs)...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29565957/association-of-higher-migraine-risk-among-female-and-younger-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-of-one-million
#17
Jiunn-Horng Chen, Shih-Chi Wu, Chih-Hsin Muo, Chia-Hung Kao, Chun-Hung Tseng, Chon-Haw Tsai
BACKGROUND: Inflammation may trigger migraine development through neurovascular reactions in the brain. Most of the migraine patients, particularly the younger ones, do not have any risk factors for this disease. Hence, we assessed whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases the risk of migraine. OBJECTIVE: We aim to evaluate the risk of migraine among female and middle-age COM patients with a large patient sample. STUDY DESIGN: A retrospective cohort study was conducted in this study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29561423/risks-of-female-genital-tract-related-cancers-gynecological-cancers-or-breast-cancer-in-women-with-and-without-chronic-kidney-disease-a-population-based-cohort-study-in-taiwan
#18
Wen-Hsun Chang, Huann-Cheng Horng, Chang-Ching Yeh, Chao-Yu Guo, Yiing-Jeng Chou, Nicole Huang, Hsin-Yi Huang, Yi-Jen Chen, Wen-Ling Lee, Peng-Hui Wang
This article aims to test the hypothesis that the risk of female genital tract related cancer (gynecological cancer: GC) or breast cancer (BC) of women with chronic kidney disease (CKD) might be different from that of those women without CKD.A nationwide 17-year historic cohort study using the National Health Insurance Research Database (NHIRD) of Taiwan and the Registry for Catastrophic Illness Patients was conducted. A total of 3045 women with a diagnosis of CKD from 1996 to 2013 and 3045 multivariable-matched controls (1:1) were selected...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29560612/association-between-nonsteroidal-anti-inflammatory-drugs-and-atrial-fibrillation-among-a-middle-aged-population-a-nationwide-population-based-cohort
#19
Shao-Yuan Chuang, Pai-Feng Hsu, Fang-Ju Lin, Ya-Wen Huang, Gou-Zhau Wang, Wei-Chiao Chang, Hui-Ju Tsai
AIMS: It remains inconclusive whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of atrial fibrillation (AF), especially in middle-aged Asian populations. In this study, we evaluated the association between NSAID use and the risk of AF in a nationwide population-based study of middle-aged individuals in Taiwan. METHODS: A nested case-control study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan...
March 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29559842/advancis-score-predicts-acute-kidney-injury-after-percutaneous-coronary-intervention-for-acute-coronary-syndrome
#20
Pei-Chun Fan, Tien-Hsing Chen, Cheng-Chia Lee, Tsung-Yu Tsai, Yung-Chang Chen, Chih-Hsiang Chang
Acute kidney injury (AKI), a common and crucial complication of acute coronary syndrome (ACS) after receiving percutaneous coronary intervention (PCI), is associated with increased mortality and adverse outcomes. This study aimed to develop and validate a risk prediction model for incident AKI after PCI for ACS. We included 82,186 patients admitted for ACS and receiving PCI between 1997 and 2011 from the Taiwan National Health Insurance Research Database and randomly divided them into a training cohort (n = 57,630) and validation cohort (n = 24,656) for risk model development and validation, respectively...
2018: International Journal of Medical Sciences
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