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https://www.readbyqxmd.com/read/28722669/hydroxychloroquine-and-risk-of-cancer-in-patients-with-primary-sj%C3%A3-gren-syndrome-propensity-score-matched-landmark-analysis
#1
Yao-Fan Fang, Yen-Fu Chen, Ting-Ting Chung, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Chang-Fu Kuo, Jenn-Haung Lai
Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [1]. We investigated the effect of hydroxychloroquine on cancer risk in patients with primary Sjögren syndrome(pSS). We used the Taiwan National Health Insurance Database to compare cancer incidence between incident pSS patients with or without at least 6-month hydroxychloroquine use within a 1- or 3-year period. Propensity score matched landmark analysis was used. We included 4194 alive patients without cancer 1 year after pSS diagnosis from 2000 through 2005...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28715497/risk-of-gestational-hypertension-preeclampsia-in-women-with-preceding-endometriosis-a-nationwide-population-based-study
#2
Mei-Lien Pan, Li-Ru Chen, Hsiao-Mei Tsao, Kuo-Hu Chen
OBJECTIVE: To investigate the association between preceding endometriosis and gestational hypertension-preeclampsia (GH-PE). METHODS: In this nationwide population-based longitudinal study, data from 1998-2012 Taiwan National Health Insurance Research Database were used. We used ICD9-CM codes 617.X and 642.X respectively for the diagnoses of endometriosis and GH-PE, which were further confirmed by examining medical records of surgeries, blood pressure and urine protein to ensure the accuracy of the diagnoses...
2017: PloS One
https://www.readbyqxmd.com/read/28712594/an-age-stratified-longitudinal-study-of-primary-spontaneous-pneumothorax
#3
Yuan Huei Huang, Pei Yeh Chang, Kin Sun Wong, Chee Jen Chang, Jin Yao Lai, Jeng Chang Chen
PURPOSE: The objective of this study was to determine the age-stratified incidence, frequency, and duration of recurrence of primary spontaneous pneumothorax (PSP). METHODS: This study analyzed the epidemiology of PSP among hospitalized patients using the National Health Research Institutes of Taiwan database. The incidence of PSP was determined from a cohort of 19,562 deidentified individuals with PSP between 2001 and 2013. The insurants consisted of 99% of the Taiwan population of about 23 million people...
July 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28711910/combined-renin-angiotensin-aldosterone-system-blockade-and-statin-therapy-effectively-reduces-the-risk-of-cerebrovascular-accident-in-autosomal-dominant-polycystic-kidney-disease-a-nationwide-population-based-cohort-study
#4
Pei-Hsun Sung, Hsin-Ju Chiang, Mel S Lee, John Y Chiang, Hon-Kan Yip, Yao-Hsu Yang
Fairly limited data reported the incidence and risk of cerebrovascular accident (CVA) in autosomal dominant polycystic kidney disease (ADPKD). Additionally, little is known regarding the therapeutic impact of renin-angiotensin-aldosterone system (RAAS) blockade and statin on reducing the occurrence of CVA in ADPKD. We utilized the data from Taiwan National Health Insurance Research Database (NHIRD) to perform a population-based cohort study (1997-2013). A total of 2,647 patients with ADPKD were selected from 1,000,000 general population after excluding patients with age<18, renal replacement therapy and concomitant diagnosis of CVA...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28709117/increased-risk-of-bipolar-disorder-in-patients-with-scabies-a-nationwide-population-based-matched-cohort-study
#5
Chien-Yu Lin, Fung-Wei Chang, Jing-Jung Yang, Chun-Hung Chang, Chia-Lun Yeh, Wei-Te Lei, Chun-Fa Huang, Jui-Ming Liu, Ren-Jun Hsu
Both scabies and bipolar disorder (BD) are common and troublesome disorders. There are several similarities in both diseases: pruritus, a higher prevalence in crowded environments, and cytokine-mediated inflammatory processes in the pathophysiology. We conducted this nationwide population-based study to investigate the possible relationship between scabies and BD. Based on the National Health Insurance Research Database (NHIRD) of Taiwan, a total of 7096 patients with scabies were identified as a study group and 28,375 matched patients as a control...
July 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28708880/pediatric-sleep-apnea-and-depressive-disorders-risk-a-population-based-15-year-retrospective-cohort-study
#6
Chun-Hung Chang, Shaw-Ji Chen, Chieh-Yu Liu
BACKGROUND: Studies have shown a higher risk of depressive disorders in children with sleep apnea than in those without sleep apnea. However, the association between sleep apnea and subsequent depressive disorders in the pediatric population remains undetermined. Thus, this study investigated the risk of depressive disorders among pediatric patients with sleep apnea. METHODS: In this study, the population-based National Health Insurance Research Database of Taiwan was used to identify patients who had first been diagnosed with sleep apnea between 1999 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28707364/furosemide-use-and-acute-risk-of-hip-fracture-in-older-people-a-nationwide-case-control-study-in-taiwan
#7
Shih-Wei Lai, Kao-Chi Cheng, Cheng-Li Lin, Kuan-Fu Liao
AIM: Little is known about the acute effects of furosemide use on the risk of hip fracture. The aim of the present study was to evaluate the association between furosemide use and acute risk of hip fracture in older people in Taiwan. METHODS: We carried out a retrospective nationwide case-control study using the database of the Taiwan National Health Insurance Program. A total of 4523 older adults aged ≥65 years with newly diagnosed hip fracture from 2000 to 2013 were identified as the cases...
July 14, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28701282/risk-factors-for-myocardial-dysfunction-after-traumatic-brain-injury-a-one-year-follow-up-study
#8
Kang Lu, Cheng-Loong Liang, Ping-Chia Li, Po-Chou Liliang, Chih-Yuan Huang, Yi-Che Lee, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun, Hao-Kuang Wang
INTRODUCTION: Traumatic brain injury has been associated with an increased risk of myocardial dysfunction. Common abnormalities accompanying this pathology include electrocardiographic abnormalities, elevated creatine kinase levels, arrhythmias, and pathologic changes of the myocardium. The aim of this study was to determine if TBI patients have a higher risk of myocardial dysfunction than the general population and to identify the risk factors of myocardial dysfunction in TBI patients...
July 8, 2017: Injury
https://www.readbyqxmd.com/read/28698956/risk-of-developing-pleural-empyema-in-patients-with-stroke-a-propensity-matched-cohort-study
#9
Te-Chun Shen, Chi-Yu Lin, Cheng-Li Lin, Chia-Hung Chen, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung
Pleural empyema is an important complication of pneumonia. Patients with stroke are at a higher risk developing pneumonia; however, the association between stroke and pleural empyema risk is largely unknown. We used the data from the National Health Insurance Research Database of Taiwan to establish a stroke group consisting of 466,170 patients diagnosed between 2000 and 2010, and a non-stroke group consisting of the same number of individuals matched by the propensity score. Incident pleural empyema was monitored toward the end of 2011...
July 11, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28698490/birth-trends-among-female-physicians-in-taiwan-a-nationwide-survey-from-1996-to-2013
#10
Yi-Jen Wang, Shu-Chiung Chiang, Tzeng-Ji Chen, Li-Fang Chou, Shinn-Jang Hwang, Jui-Yao Liu
Background: Although more and more women are becoming physicians, their decisions regarding pregnancy may be affected by the lengthy period of medical education and postgraduate training. The aim of this study was to explore the birth trends among female physicians in Taiwan; Methods: Retrospective analyses of maternal ages at delivery from 1996 to 2013, both for physicians and the general population, were conducted using a nationwide dataset called National Health Insurance Research Database; Results: During the study period, 8540 female physicians were identified...
July 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28693443/association-of-benzodiazepine-and-z-drug-use-with-the-risk-of-hospitalisation-for-fall-related-injuries-among-older-people-a-nationwide-nested-case-control-study-in-taiwan
#11
Nan-Wen Yu, Pei-Jung Chen, Hui-Ju Tsai, Chih-Wan Huang, Yu-Wen Chiu, Wen-Ing Tsay, Jui Hsu, Chia-Ming Chang
BACKGROUND: Non-benzodiazepine hypnotics (Z-drugs) are advocated to be safer than benzodiazepines (BZDs). This study comprehensively investigated the association of BZD and Z-drug usage with the risk of hospitalisation for fall-related injuries in older people. METHODS: This study used the Taiwan National Health Insurance Database with a nested matched case-control design. We identified 2238 elderly patients who had been hospitalised for fall-related injuries between 2003 and 2012...
July 11, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28692645/benzodiazepine-and-z-drug-use-and-risk-of-pneumonia-in-patients-with-chronic-kidney-disease-a-population-based-nested-case-control-study
#12
Meng-Ting Wang, Yun-Han Wang, Hsin-An Chang, Chen-Liang Tsai, Ya-Sung Yang, Chen Wei Lin, Cheng-Chin Kuo, Yu-Juei Hsu
BACKGROUND: Concerns were raised about pneumonia development from benzodiazepines (BZDs) and Z-drugs, but direct evidence is limited, conflicting and without examining the highly susceptible patients with chronic kidney disease (CKD) nor specifying the risk for different drug utilizations. This study aimed to investigate whether use of BZDs and Z-drugs was each associated with an increased risk of pneumonia in a CKD population. METHODS: We performed a nested case-control study of 36,880 CKD patients analyzing the Taiwan National Health Insurance Database between 01/1/2000 and 12/31/2011...
2017: PloS One
https://www.readbyqxmd.com/read/28692580/hiv-infection-increases-the-risk-of-incident-psoriasis-a-nationwide-population-based-cohort-study-in-taiwan
#13
Yung-Feng Yen, I-An Jen, Marcelo Chen, Yu-Ching Lan, Chun-Yuan Lee, Pei-Hung Chuang, Yun Lee, Yi-Ming Arthur Chen
BACKGROUND: HIV can cause an imbalance of T lymphocytes, which may contribute to the onset of psoriasis. However, the association of HIV with incident psoriasis has not been extensively studied. OBJECTIVES: The aim of this nationwide population-based cohort study was to determine the association of HIV with incident psoriasis. METHODS: Since January 1, 2000, we identified adult people living with HIV/AIDS (PLWHA) from the Taiwan National Health Insurance Research Database...
August 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28691253/cardiovascular-disease-risk-in-patients-receiving-organ-transplantation-a-national-cohort-study
#14
Hsin-I Tsai, Fu-Chao Liu, Chao-Wei Lee, Chang-Fu Kuo, Lai-Chu See, Ting-Ting Chung, Huang-Ping Yu
Although organ transplantation is the definitive treatment for end stage organ failure, the post-transplant outcomes can be substantially influenced by cardiovascular complications. A national cohort study was performed to estimate risks of cardiovascular diseases in those with heart, lung, kidney and liver transplantation. This cohort study consisted of 5,978 solid organ transplantations identified using the Taiwan National Health Insurance Database. Cardiovascular and mortality risks in transplant recipients were evaluated using standardized incidence ratios, excess absolute risks, and standardized mortality ratios as compared to those in the general population...
July 10, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28691203/previously-undiagnosed-risk-factors-and-medication-nonadherence-are-prevalent-in-young-adults-with-first-ever-stroke
#15
Sheng-Feng Sung, Edward Chia-Cheng Lai, Darren Philbert Wu, Cheng-Yang Hsieh
PURPOSE: The incidence of stroke and prevalence of traditional vascular risk factors (VRFs) in young adults (age < 55 y) are both increasing. Young patients tend to be unaware of their VRFs and to have lower medication adherence. We examined how age affects the prevalence of previously undiagnosed VRFs and the extent of medication nonadherence among stroke patients. METHODS: Using Taiwan's National Health Insurance Research Database, we identified consecutive adult patients with first-ever stroke between 2000 and 2013...
July 10, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28688267/factors-affecting-lumbar-surgery-outcome-a-nation-wide-population-based-retrospective-study
#16
Vincent Chin-Hung Chen, Yao-Hsu Yang, Pin-Yuan Chen, Jen-Tsung Yang, Carl P C Chen, Chi-Jen Chen, Mong Liang Lu, Yena Lee, Roger S McIntyre, Yin-Cheng Huang
BACKGROUND: Lower back pain is a very common symptom and treatment strategies vary according the severity and duration of illness. Surgical approaches are becoming increasingly popular with the advent of new and less invasive technologies; however, treatment outcomes are not yet well established on a population-based level. Taiwan's National Health Insurance Research Database (NHIRD) is longitudinal and includes 98% of the population since its inception in 1995. The database includes the ICD 9...
June 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28687250/trends-in-the-incidence-of-primary-malignant-brain-tumors-in-taiwan-and-correlation-with-comorbidities-a-population-based-study
#17
Ya-Jui Lin, Hsiao-Yean Chiu, Meng-Jiun Chiou, Yin-Cheng Huang, Kuo-Chen Wei, Chang-Fu Kuo, Jun-Te Hsu, Pin-Yuan Chen
OBJECTIVE: Primary malignant brain tumors are relatively uncommon, and their incidence and survival rates have seldom been reported. PATIENTS AND METHODS: We identified all patients with malignant brain tumors in Taiwan between 1997 and 2012 using the National Health Insurance database. We estimated the stratified incidence of malignant brain tumors by age and sex. We estimated the median 1-, 2-, and 5-year survival, taking comorbidities into account. Trends for incidence and survival were analyzed using Joinpoint regression...
August 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28683023/bidirectional-association-between-fibromyalgia-and-gastroesophageal-reflux-disease-two-population-based-retrospective-cohort-analysis
#18
Jia-Chi Wang, Fung-Chang Sung, Mauranda Men, Kevin A Wang, Cheng-Li Lin, Chia-Hung Kao
Fibromyalgia (FM) tends to co-exist with gastroesophageal reflux disease (GERD). This retrospective cohort study was conducted to determine the bidirectional association between FM and GERD, using a nationwide database, the National Health Insurance of Taiwan. We established two study arms, including 35117 FM patients in Arm 1 and 34630 GERD patients in Arm 2, newly diagnosed between 2000 and 2010. For each study arm, we randomly selected 4-fold subjects with neither FM nor GERD from the same database, frequency-matched by sex, age and diagnosis date, as the respective control cohorts...
July 3, 2017: Pain
https://www.readbyqxmd.com/read/28682885/incidence-of-trigger-digits-following-carpal-tunnel-release-a-nationwide-population-based-retrospective-cohort-study
#19
Fu-Yu Lin, Oscar J Manrique, Cheng-Li Lin, Hsu-Tang Cheng
The onset of trigger digits after carpal tunnel release (CTR) have been reported inconsistently across different studies. The aim of this study is to assess the incidence of trigger digits after CTR using nationwide population cohort data.We conducted a retrospective cohort study using the Longitudinal Health Insurance Database 2000 (LHID2000) from the National Health Insurance Database (NHIRD) in Taiwan. The LHID2000 contained 1 million beneficiaries randomly selected from the year 2000 Registry for Beneficiaries in NHIRD...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28681508/tuberculosis-increases-the-risk-of-peripheral-arterial-disease-a-nationwide-population-based-study
#20
Sheng-Huei Wang, Wu-Chien Chien, Chi-Hsiang Chung, Fu-Huang Lin, Chung-Kan Peng, Chih-Feng Chian, Chih-Hao Shen
BACKGROUND AND OBJECTIVE: According to several studies, tuberculosis (TB) may be involved in the pathogenesis of cardiovascular disease. However, the relationship between TB and peripheral arterial disease (PAD) has not been studied. The aim of this study was to investigate whether patients with TB exhibit an increased risk of developing PAD. METHODS: The data assessed in this national population-based cohort study were obtained from the Taiwan National Health Insurance Database from 2000 to 2010...
July 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
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