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https://www.readbyqxmd.com/read/29055156/type-2-diabetes-remission-2-years-post-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-the-role-of-the-weight-loss-and-comparison-of-diarem-and-diabetter-scores
#1
A Pucci, U Tymoszuk, W H Cheung, J M Makaronidis, S Scholes, G Tharakan, M Elkalaawy, M Guimaraes, M Nora, M Hashemi, A Jenkinson, M Adamo, M Monteiro, N Finer, R L Batterham
AIMS: The comparative efficacy of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy on Type 2 diabetes remission and the role of weight loss are unclear. The DiaRem Type 2 diabetes remission prediction score uses HbA1c , age and Type 2 diabetes medications but not Type 2 diabetes duration. The aim of this study was to compare the predictive value of the DiaRem score with the DiaBetter score that includes Type 2 diabetes duration, upon combined (complete plus partial) 2-year post-surgery Type 2 diabetes remission in people following RYGB and sleeve gastrectomy, and to investigate the relationship between weight loss and Type 2 diabetes remission...
October 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29054919/comparison-of-elevated-phosphorylated-neurofilament-heavy-chains-in-serum-and-cerebrospinal-fluid-of-patients-with-amyotrophic-lateral-sclerosis
#2
Maxim De Schaepdryver, Andreas Jeromin, Benjamin Gille, Kristl G Claeys, Victor Herbst, Britta Brix, Philip Van Damme, Koen Poesen
OBJECTIVE: Phosphorylated neurofilament heavy chain (pNfH) levels are elevated in cerebrospinal fluid (CSF) of patients with amyotrophic lateral sclerosis (ALS). Instead of CSF, we explored blood as an alternative source to measure pNfH in patients with ALS. METHODS: In this single centre retrospective study, 85 patients with ALS, 215 disease controls (DC) and 31 ALS mimics were included. Individual serum pNfH concentrations were correlated with concentrations in CSF and with several clinical parameters...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29054749/men-with-unilateral-achilles-tendinopathy-have-impaired-balance-on-the-symptomatic-side
#3
M Scholes, S Stadler, D Connell, C Barton, R A Clarke, A L Bryant, P Malliaras
OBJECTIVES: To investigate single leg standing balance in males with mid-portion Achilles tendinopathy (AT). DESIGN: Cross sectional case study. METHODS: Centre of pressure (COP) path length was measured using a Wii Balance Board (WBB) in 21 male participants (20-60 years) with unilateral mid-portion AT during single-limb standing on each limb with eyes open and closed. Ultrasound imaging of both Achilles tendons was also performed by one blinded assessor, and the anteroposterior (AP) thickness and presence of pathology was determined...
October 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29054505/biomonitor-2-pilot-study-early-experience-with-implantation-of-the-biotronik-biomonitor-2-implantable-cardiac-monitor
#4
Sze-Yuan Ooi, Ben Ng, Suresh Singarayar, Kevin Hellestrand, Peter Illes, Uwais Mohamed, Shakeeb Razak, Rukshen Weerasooriya
BACKGROUND: The BioMonitor 2 Pilot Study assessed the implantation procedure, the sensing amplitude and the remote monitoring transmission success rate of the second generation implantable cardiac monitor, the BioMonitor 2 (Biotronik, Berlin, Germany). METHODS: This was a prospective, multi-centre, single-arm, non-randomised study involving seven operators in five sites across Australia. Data were collected at implantation, during clinic visits at 1 week and 1 month post-implantation, and through wireless remote monitoring...
October 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29054320/eradication-of-helicobacter-pylori-infection-with-a-new-bismuth-based-quadruple-therapy-in-clinical-practice
#5
Elena Pérez-Arellano, María Isabel Rodriguez-Garcia, Ana Belen Galera Rodenas, Emilio de la Morena-Madrigal
INTRODUCTION: The eradication of Helicobacter pylori infection represents a clinical challenge. OBJECTIVE: To evaluate the efficacy and safety of quadruple therapy with esomeprazole plus a 3-in-1 capsule containing bismuth subcitrate, metronidazole and tetracycline, plus probiotics in patients diagnosed with H. pylori infection in routine clinical practice. METHODS: A prospective, interventional, single-centre and open-label study in consecutive patients with a confirmed indication for eradication of H...
October 17, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/29054183/appropriateness-of-elective-percutaneous-coronary-intervention-and-impact-of-government-health-insurance-scheme-a-tertiary-centre-experience-from-western-india
#6
Devendra Patil, Charan Lanjewar, Goutam Vaggar, Juhi Bhargava, Girish Sabnis, Jivtesh Pahwa, Ankur Phatarpekar, Hetan Shah, Prafulla Kerkar
BACKGROUND: There is a dearth of data regarding the appropriateness of elective percutaneous coronary intervention (PCI) in a limited-resource country such as India. In an attempt to rationalise the use of PCI, Appropriate Use Criteria (AUC) were developed for cardiovascular care in the USA. In the Indian context, considering the high prevalence of coronary artery disease, the dramatic rise in the number of revascularization procedures and an increasing role of government/private reimbursements, application of AUC could potentially guide policy to optimize the utilization of resources and the benefit-risk ratio for individual patients...
September 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/29054109/influence-of-backside-loading-on-the-floating-mass-transducer-an-in-vitro-experimental-study
#7
Antoniu-Oreste Gostian, Martin Sylvester Otte, David Pazen, Magdalene Ortmann, David Schwarz, Karl Bernd Hüttenbrink, Dirk Beutner
HYPOTHESIS: The vibration of the floating mass transducer (FMT) of a single active middle-ear implant (AMEI) is distinctly influenced by the properties of the material coupled to its back side. BACKGROUND: In round window vibroplasty, the FMT needs to be padded against the surrounding bone opposite from the round window membrane. This represents one factor influencing its performance as a round window driver. Therefore, we examined the effects of different materials linked to the back side of an FMT on its vibration range...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053231/effects-of-common-cold-and-concomitant-administration-of-nasal-decongestant-on-the-pharmacokinetics-and-pharmacodynamics-of-nasal-glucagon-in-otherwise-healthy-participants-a-randomized-clinical-trial
#8
Cristina B Guzman, Helene Dulude, Claude Piché, Marianne Rufiange, Aziz A Sadoune, Emmanouil Rampakakis, Dolores Carballo, Myriam Triest, Michelle Xiaotian Zhang, Shuyu Zhang, Maryam Tafreshi, Eric Sicard
AIMS: Nasal glucagon (NG) is a nasally-administered glucagon powder, absorbed through the nasal mucosa, designed for treatment of severe hypoglycaemia. This study evaluated safety, pharmacokinetics (PK), and pharmacodynamics (PD) of NG in otherwise healthy participants with common colds and after recovery from cold symptoms, with and without concomitant nasal decongestant. MATERIALS AND METHODS: This was a single-centre, open-label study. Cohort 1 participants (N=18) received two NG doses: one while experiencing nasal congestion and another after recovery from cold symptoms...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29049746/degree-of-pulmonary-fissure-completeness-can-predict-postoperative-cardiopulmonary-complications-and-length-of-hospital-stay-in-patients-undergoing-video-assisted-thoracoscopic-lobectomy-for-early-stage-lung-cancer
#9
Shuangjiang Li, Kun Zhou, Mingming Wang, Rongjia Lin, Jun Fan, Guowei Che
OBJECTIVES: To estimate the effects of pulmonary fissure completeness on postoperative cardiopulmonary complications (PCCs) and hospital stay in patients undergoing video-assisted thoracoscopic surgery lobectomy for early-stage non-small-cell lung cancer. METHODS: We performed a single-centre retrospective analysis based on the prospectively maintained data of our institution during the study period. Demographic differences between the PCC group and the non-PCC group were initially examined...
August 11, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049665/reoperation-for-mitral-paravalvular-leak-a-single-centre-experience-with-200-patients
#10
Sameh M Said, Hartzell V Schaff, Kevin L Greason, Alberto Pochettino, Richard C Daly, Joseph A Dearani
OBJECTIVES: Paravalvular leak (PVL) is a major cause of morbidity and mortality after mitral valve replacement. Risk factors and data on long-term surgical outcomes are lacking. METHODS: Between January 1995 and December 2012, 206 [118 males (57%)] patients underwent reoperation due to mitral PVL. Mean age was 64 ± 11 years. Haemolytic anaemia was present in 85 (41%) patients, while 137 (67%) patients were in New York Heart Association Class III or IV. Baseline creatinine was above 1...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049617/survival-results-of-postoperative-coronary-angiogram-for-treatment-of-perioperative-myocardial-ischaemia-following-coronary-artery-bypass-grafting-a-single-centre-experience
#11
Maximilian J Preußer, Jan Landwehrt, Stefano Mastrobuoni, Fausto Biancari, Abdul R Dakkak, Mosab Alshakaki, Sven Martens, Angelo M Dell'Aquila
OBJECTIVES: Although perioperative myocardial ischaemia (PMI) is a well-known complication following coronary artery bypass grafting (CABG), standard strategies for its diagnosis and treatment are so far not defined. In this study, we sought to evaluate the impact on survival of postoperative coronary angiogram for management of patients with PMI after CABG. METHODS: Overall, 4028 patients underwent isolated CABG in a single-centre institution between January 2006 and September 2013...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049525/impact-of-the-haga-braincare-strategy-on-the-burden-of-haemodynamic-and-embolic-strokes-related-to-cardiac-surgery
#12
Friso Duynstee, Ruud W M Keunen, Agnes van Sonderen, Ali M Keyhan-Falsafi, Gerard J F Hoohenkerk, Gayleen Stephens, Erik Teeuws, Jan W K van Alphen, Dénes L J Tavy, Arne Mosch, Sebastiaan F T M de Bruijn, Hans van Overhagen, Frank E E Treurniet, Lucas C van Dijk, Paulien M van Kampen
OBJECTIVES: This study prospectively evaluates the impact of the Haga Braincare Strategy (HBS) on the occurrence of haemodynamic and embolic stroke in a cohort of patients who underwent coronay artery bypass grafting (CABG), valve replacement of a combination of both types of surgery between 2012 and 2015 at the Haga Teaching Hospitals. METHODS: The HBS is a dual strategy based on a preoperative vascular work-up of the cerebral circulation by transcranial Doppler and a perioperative monitoring of the cerebral circulation by cerebral oximetry...
June 15, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29048474/transinnominate-approach-for-transcatheter-aortic-valve-replacement-single-centre-experience-of-minimally-invasive-alternative-access
#13
Luigi Pirelli, Jacob S Scheinerman, Derek R Brinster, Nirav C Patel, Alaeldin Eltom, Jonathan M Hemli, Chad A Kliger
OBJECTIVES: Iliofemoral arteries have been the preferred access for transcatheter aortic valve replacement (TAVR). When these arteries are too small, calcified or tortuous, an alternative access must be considered. Transinnominate (TI) access is an extrathoracic approach that does not require manipulation of major neurovascular structures or the apex. The aim of this study is to evaluate the efficacy and safety of TI TAVR as an alternative access in patients with severe aortic stenosis not amenable to a transfemoral approach...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29045311/cardiac-resynchronization-therapy-outcomes-in-patients-with-chronic-heart-failure-cardiac-resynchronization-therapy-with-pacemaker-versus-cardiac-resynchronization-therapy-with-defibrillator
#14
Michael Drozd, John Gierula, Judith E Lowry, Maria F Paton, Eleanor Joy, Haqeel A Jamil, Richard M Cubbon, Mark T Kearney, David A Cairns, Klaus K Witte
AIMS: Cardiac resynchronization therapy (CRT) for chronic heart failure with left ventricular systolic dysfunction (LVSD) consistently improves survival against optimal medical therapy alone. Limited data exist comparing the outcomes between CRT with pacemaker (CRT-P) and with defibrillator (CRT-D). We aimed to investigate the long-term prognosis of patients who received CRT-P or CRT-D. METHODS AND RESULTS: Data were prospectively collected from consecutive patients with standard indications for CRT, who were implanted at a single large tertiary centre between 2008 and 2012...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29044979/real-world-visual-outcomes-in-patients-with-neovascular-age-related-macular-degeneration-receiving-aflibercept-at-fixed-intervals-as-per-uk-license
#15
Mehmet Ozturk, Martin L Harris, Vuong Nguyen, Daniel Barthelmes, Mark C Gillies, Hemal Mehta
IMPORTANCE: To assess the impact of injection frequency on visual outcomes in patients with neovascular age-related macular degeneration (nAMD) treated with intravitreal aflibercept. BACKGROUND: The UK license for treatment of nAMD with aflibercept is based on the VIEW protocol. We tested the hypothesis that patients receiving fewer than the 8 recommended injections in the first year would experience worse visual outcomes. DESIGN: Retrospective, single-centre observational study...
October 17, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29042543/quantum-sensing-of-weak-radio-frequency-signals-by-pulsed-mollow-absorption-spectroscopy
#16
T Joas, A M Waeber, G Braunbeck, F Reinhard
Quantum sensors-qubits sensitive to external fields-have become powerful detectors for various small acoustic and electromagnetic fields. A major key to their success have been dynamical decoupling protocols which enhance sensitivity to weak oscillating (AC) signals. Currently, those methods are limited to signal frequencies below a few MHz. Here we harness a quantum-optical effect, the Mollow triplet splitting of a strongly driven two-level system, to overcome this limitation. We microscopically understand this effect as a pulsed dynamical decoupling protocol and find that it enables sensitive detection of fields close to the driven transition...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29042392/renal-and-cardiovascular-effects-of-sodium-glucose-cotransporter-2-sglt2-inhibition-in-combination-with-loop-diuretics-in-diabetic-patients-with-chronic-heart-failure-recede-chf-protocol-for-a-randomised-controlled-double-blind-cross-over-trial
#17
Natalie A Mordi, Ify R Mordi, Jagdeep S Singh, Fatima Baig, Anna-Maria Choy, Rory J McCrimmon, Allan D Struthers, Chim C Lang
INTRODUCTION: Type 2 diabetes (T2D) and heart failure (HF) are a frequent combination, where treatment options remain limited. There has been increasing interest around the sodium-glucose cotransporter 2 (SGLT2) inhibitors and their use in patients with HF. Data on the effect of SGLT2 inhibitor use with diuretics are limited. We hypothesise that SGLT2 inhibition may augment the effects of loop diuretics and the benefits of SGLT2 inhibitors may extend beyond those of their metabolic (glycaemic parameters and weight loss) and haemodynamic parameters...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042177/antibiotic-exposure-and-interpersonal-variance-mask-the-effect-of-ivacaftor-on-respiratory-microbiota-composition
#18
Anton Y Peleg, Jocelyn Choo, Katherine Langan, Deirdre Edgeworth, Dominic Keating, John Wilson, Geraint B Rogers, Tom Kotsimbos
BACKGROUND: G551D is a class III mutation of the cystic fibrosis transmembrane regulator (CFTR) that results in impaired chloride channel function in cystic fibrosis (CF). Ivacaftor, a CFTR-potentiating agent improves sweat chloride, weight, lung function, and pulmonary exacerbation rate in CF patients with G551D mutations, but its effect on the airway microbiome remains poorly characterised. METHODS: Twenty CF patients with at least one G551D mutation from a single centre were recruited to a 4month double-blind, placebo-controlled, crossover study of ivacaftor with 28days of active treatment...
October 14, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29042091/effects-of-renal-denervation-on-coronary-flow-reserve-and-forearm-dilation-capacity-in-patients-with-treatment-resistant-hypertension-a-randomized-double-blinded-sham-controlled-clinical-trial
#19
Morten Engholm, Jannik B Bertelsen, Ole N Mathiassen, Hans E Bøtker, Henrik Vase, Christian D Peters, Jesper N Bech, Niels H Buus, Anne P Schroeder, Hans Rickers, Klavs W Hansen, Per L Poulsen, Anne Kaltoft, Kent L Christensen
BACKGROUND: Microvascular impairment is well documented in hypertension. We investigated the effect of renal sympathetic denervation (RDN) on cardiac and peripheral microvasculature in patients with treatment-resistant essential hypertension (TRH). METHODS: A randomized, single centre, double-blinded, sham-controlled clinical trial. Fifty-eight patients with TRH (ambulatory systolic BP (ASBP) ≥ 145mmHg) despite stable treatment were randomized to RDN or SHAM. RDN was performed with the unipolar Medtronic Flex catheter...
October 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29040595/a-comparison-of-levofloxacin-and-oral-third-generation-cephalosporins-as-antibacterial-prophylaxis-in-acute-leukaemia-patients-during-chemotherapy-induced-neutropenia
#20
Kristyn E Yemm, Jason N Barreto, Kristin C Mara, Ross A Dierkhising, Naseema Gangat, Pritish K Tosh
Background: There is demonstrated benefit with fluoroquinolones as infection prophylaxis in neutropenic patients; however, side effects, drug interactions and increasing resistance necessitate investigation of alternative therapies. Objectives: To compare the incidence of febrile neutropenia in high-risk patients with haematological malignancy receiving a fluoroquinolone with those receiving an oral third-generation cephalosporin (OTGC) as antibacterial prophylaxis during chemotherapy-induced neutropenia...
October 11, 2017: Journal of Antimicrobial Chemotherapy
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