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https://www.readbyqxmd.com/read/29909373/what-insights-do-patients-and-caregivers-have-on-acute-kidney-injury-and-posthospitalisation-care-a-single-centre-qualitative-study-from-toronto-canada
#1
Samuel A Silver, Marianne Saragosa, Neill K Adhikari, Chaim M Bell, Ziv Harel, Andrea Harvey, Abhijat Kitchlu, Javier A Neyra, Ron Wald, Lianne Jeffs
OBJECTIVES: Hospitalisation with acute kidney injury (AKI) is associated with short-term and long-term adverse events, but patient and caregiver experiences with AKI are not well described. We sought to better understand patient and caregiver perspectives after a hospitalisation with AKI to inform discharge strategies that may improve outcomes for this high-risk population. DESIGN: Qualitative study with semistructured interviews. SETTING: Tertiary care hospital in Toronto, Ontario, Canada...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29908832/cardiac-resynchronization-therapy-guided-by-cardiac-magnetic-resonance-imaging-a-prospective-single-centre-randomized-study-cmr-crt
#2
Radka Kočková, Kamil Sedláček, Dan Wichterle, Viktor Šikula, Jaroslav Tintěra, Helena Jansová, Alena Pravečková, Renata Langová, Lukáš Krýže, Wael El-Husseini, Markéta Segeťová, Josef Kautzner
BACKGROUND: Cardiac resynchronization therapy (CRT) improves symptoms of heart failure (HF), morbidity and mortality in selected population. The aim of the study was to investigate the impact of cardiac magnetic resonance (CMR)-guided left ventricular (LV) lead placement on clinical outcomes and LV reverse remodelling in CRT recipients. METHODS: Patients with CRT indication were randomized for CMR-guided (CMR group) or electrophysiologically guided (EP group) LV lead placement between 2011 and 2014...
June 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29907242/does-culture-affect-usability-a-trans-european-usability-and-user-experience-assessment-of-a-falls-risk-connected-health-system-following-a-user-centred-design-methodology-carried-out-in-a-single-european-country
#3
Vera Stara, Richard Harte, Mirko Di Rosa, Liam Glynn, Monica Casey, Patrick Hayes, Lorena Rossi, Anat Mirelman, Paul M A Baker, Leo R Quinlan, Gearóid ÓLaighin
BACKGROUND: User-centred design (UCD) is a process whereby the end-user is placed at the centre of the design process. The WIISEL (Wireless Insole for Independent and Safe Elderly Living) system is designed to monitor fall risk and to detect falls, and consists of a pair of instrumented insoles and a smartphone app. The system was designed using a three-phase UCD process carried out in Ireland, which incorporated the input of Irish end-users and multidisciplinary experts throughout. OBJECTIVE: In this paper we report the results of a usability and user experience (UX) assessment of the WIISEL system in multiple countries and thus establish whether the UCD process carried out in Ireland produced positive usability and UX results outside of Ireland...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29905907/-68-ga-psma-11-pet-ct-in-prostate-cancer-patients-with-biochemical-recurrence-after-radical-prostatectomy-and-psa-0-5-ng-ml-efficacy-and-impact-on-treatment-strategy
#4
Andrea Farolfi, Francesco Ceci, Paolo Castellucci, Tiziano Graziani, Giambattista Siepe, Alessandro Lambertini, Riccardo Schiavina, Filippo Lodi, Alessio G Morganti, Stefano Fanti
PURPOSE: The primary aim of this retrospective, single-centre analysis was to assess the performance of 68 Ga-PSMA-11 PET/CT in prostate cancer (PCa) patients in early PSA failure after radical prostatectomy (RP). The secondary aim was to assess the potential impact of 68 Ga-PSMA-11 PET/CT on treatment strategy. METHODS: 68 Ga-PSMA-11 PET/CT is performed in our institution within an investigational new drug (IND) trial in PCa patients with biochemical recurrence (BCR)...
June 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29904602/a-closed-system-irrigation-drainage-technique-for-surgical-evacuation-of-chronic-subdural-haematomas
#5
Haider Kareem, Hadie Adams
Background: Chronic subdural haematoma (CSDH), is a common neurosurgical disorder that is associated with morbidity and mortality affecting the ageing population. The aim is to present the treatment experience of CSDH patients treated with a technique that combines the classical single burr-hole irrigation and the continuous closed system drainage: The closed system irrigation & drainage (CSID) technique. Methods: The cases undergoing CSDH evacuation with the CSID method were captured over a 4-year period at a tertiary neurosurgical centre...
2018: F1000Research
https://www.readbyqxmd.com/read/29904451/thrombolysis-is-an-effective-and-safe-therapy-in-stuck-mitral-valves-with-delayed-presentation-as-well-as-hemodynamically-unstable-patients-a-single-centre-study
#6
Arun Shivajirao Bade, Shakil Sattar Ahmed Shaikh, Hemant Khemani, Gurkirat Singh, Narender Omprakash Bansal
Background: Thrombosis is a complication of prosthetic valves on oral anticoagulants which is associated with significant morbidity and mortality. A re-operation carries a substantial risk, with mortality rate from 10% to 15% in selected series, which may be 2- or 3-folds higher in critically ill patients. This study conducted in a tertiary care cardiology unit aimed to evaluate the effectiveness and safety of thrombolytic therapy in stuck mitral bileaflet heart valves. Methods: As a prospective observational study, clinical symptoms and fluoroscopy were the mainstay in diagnosis of stuck mitral valve...
June 2018: Cardiology Research
https://www.readbyqxmd.com/read/29903720/cord-milking-versus-immediate-clamping-in-preterm-infants-a-randomised-controlled-trial
#7
Walid El-Naggar, David Simpson, Arif Hussain, Anthony Armson, Linda Dodds, Andrew Warren, Robin Whyte, Douglas McMillan
OBJECTIVE: To investigate whether umbilical cord milking (UCM) at birth improves systemic blood flow and short-term outcomes, as compared with immediate cord clamping (ICC). DESIGN: Randomised clinical trial. SETTING: Single tertiary care centre. PATIENTS: Infants born to eligible women presenting in preterm labour between 24 and 31 weeks' gestation. INTERVENTIONS: UCM three times at birth or ICC...
June 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29903395/incidence-prognosis-and-prediction-of-haemorrhagic-transformation-after-revascularisation-for-stroke
#8
P B García Jurado, E Roldán Romero, M E Pérez Montilla, R Valverde Moyano, I M Bravo Rey, F Delgado Acosta, F A Bravo-Rodríguez
INTRODUCTION: Haemorrhagic transformation is a major complication of acute ischaemic stroke (AIS). We sought to determine the predictors and clinical impact of intracranial haemorrhage (ICH) after revascularisation therapy. METHODS: We conducted a retrospective, single-centre study including 235 patients with AIS who underwent intravenous recombinant tissue plasminogen activator (IV-rtPA) therapy and/or endovascular treatment. A binary logistic regression model was used to determine the variables associated with ICH, parenchymal haematomas (PH), modified Rankin Scale (mRS) scores, and mortality...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29902988/additional-hepatic-166-ho-radioembolization-in-patients-with-neuroendocrine-tumours-treated-with-177-lu-dotatate-a-single-center-interventional-non-randomized-non-comparative-open-label-phase-ii-study-hepar-plus-trial
#9
Arthur J A T Braat, Dik J Kwekkeboom, Boen L R Kam, Jaap J M Teunissen, Wouter W de Herder, Koen M A Dreijerink, Rob van Rooij, Gerard C Krijger, Hugo W A M de Jong, Maurice A A J van den Bosch, Marnix G E H Lam
BACKGROUND: Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases. Treatment with peptide receptor radionuclide therapy (PRRT) shows a high objective response rate and long median survival after treatment. However, complete remission is almost never achieved. The liver is the most commonly affected organ in metastatic disease and is the most incriminating factor for patient survival...
June 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29902283/botulinum-toxin-chemodenervation-for-childhood-strabismus-in-england-national-and-local-patterns-of-practice
#10
Ameenat Lola Solebo, Anne-Marie Austin, Maria Theodorou, Chris Timms, Joanne Hancox, Gillian G W Adams
BACKGROUND: Botulinum toxin injection chemodenervation is a well-established intervention for adult strabismus, and has also been recognised as an effective alternative to routine incisional surgery for paediatric disease. We aimed to investigate the temporal patterns of practice, indications and outcomes of chemodenervation for paediatric strabismus at national and tertiary centre level. METHODS: Retrospective study using routinely collected patient data: Hospital Episode Statistics (HES) data were used to identify children undergoing non-incisional strabismus procedures in England from 2007 to 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29901810/on-x-mitral-valve-replacement-a-single-centre-experience-in-318-patients
#11
Giacomo Murana, Jacopo Alfonsi, Carlo Savini, Carlo Mariani, Giuditta Coppola, Valeria Lo Coco, Emanuele Pilato, Davide Pacini, Roberto Di Bartolomeo
OBJECTIVES: If mitral valve repair is not feasible, mitral valve replacement remains the only option. Based on our overall experience with the On-X mitral valve, the aim of this study was to investigate early and late outcomes after mitral valve replacement using this latest generation prosthesis. METHODS: From 1998 to 2016, 600 patients received an On-X prosthesis in the mitral position. Of them, we excluded all patients who had combined aortic procedures and retrospectively analysed 318 consecutive patients who had a mitral valve replacement...
June 12, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29901719/inguinal-vascular-complications-after-ablation-of-atrial-fibrillation-an-economic-impact-assessment
#12
Kerstin Bode, Laura Ueberham, Susan Gawlik, Gerhard Hindricks, Andreas Bollmann
Aims: Ablation of atrial fibrillation (AF) is recommended in the guidelines as a Class Ia/IIa indication. However, associated complications should not be dismissed; specifically, inguinal vascular complications (IVC). Although IVCs are generally considered trivial, they represent an economic burden for the procedure-performing hospital and the patient. Therefore, the ability to monitor and ultimately minimize potential complications is of considerable interest. Methods and results: An economic model was developed to calculate the economic impact for certain IVC-types from a large German single-centre perspective in 2015 and 2016...
June 12, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29901286/echocardiographic-predictors-of-change-in-renal-function-with-intravenous-diuresis-for-decompensated-heart-failure
#13
Stephen A Gannon, Kenneth J Mukamal, James D Chang
AIMS: The aim of this study was to identify echocardiographic predictors of improved or worsening renal function during intravenous diuresis for decompensated heart failure. Secondary aim included defining the incidence and clinical risk factors for acute changes in renal function with decongestion. METHODS AND RESULTS: A retrospective review of 363 patients admitted to a single centre for decompensated heart failure who underwent intravenous diuresis and transthoracic echocardiography was conducted...
June 14, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29900493/filovirus-filament-proteins
#14
Daniel R Beniac, Lindsey L Lamboo, Timothy F Booth
Filoviruses are highly filamentous enveloped animal viruses that can cause severe haemorrhagic fevers. The filovirus ribonucleoprotein forms a highly organized double-layered helical nucleocapsid (NC) containing five different virally encoded proteins. The inner layer consists of NP, the RNA binding protein, complexed with the monopartite linear genome. A distinctive outer layer links individual NP subunits with bridges composed of VP24-VP35 heterodimers, which achieves condensation of the NP-RNA into tight helical coils...
2018: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/29898675/in-hospital-major-arrhythmias-arrhythmic-death-and-resuscitation-after-successful-primary-percutaneous-intervention-for-acute-transmural-infarction-a-retrospective-single-centre-cohort-study
#15
Marco Albanese, Korhan Alpaslan, Taoufik Ouarrak, Peter Merguet, Steffen Schneider, Wolfgang Schöls
BACKGROUND: Transmural acute myocardial infarction (AMI) is associated with a high risk for ventricular arrhythmia before, during and after treatment. Consequently, it is recommended that patients diagnosed with transmural AMI be monitored in a cardiac care unit (CCU) so life-threatening arrhythmias can be treated promptly. We examined the incidence and timing of in-hospital malignant ventricular arrhythmias, sudden cardiac or arrhythmic death (SCD/AD) and resuscitation requirements in patients with transmural AMI recovering from percutaneous coronary intervention (PCI) undertaken within 12 h of symptom onset and without antecedent thrombolysis...
June 14, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29898280/upper-gastrointestinal-bleeding-in-neck-of-femur-fracture-patients-a-single-tertiary-centre-experience
#16
Jessamine Liu, Rohit Gupta, Karen Hay, Chrys Pulle, Tony Rahman, Shaun Pandy
This study aimed to identify the incidence of perioperative acute upper gastrointestinal bleeding (UGIB) in our hip fracture patients; to evaluate the characteristics, management and clinical outcomes of these patients; and to explore risk factors and protective factors. Of the 1691 consecutive patients admitted for surgical management of hip fractures, 11 (0.65%) had UGIB and a further four patients for each case were selected as controls for evaluation of risk factors and protective factors. Pre-existing peptic ulcer disease was identified as a risk factor for acute UGIB (odds ratio 7...
June 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29897979/increased-risk-of-suicide-in-new-south-wales-men-with-prostate-cancer-analysis-of-linked-population-wide-data
#17
David P Smith, Ross Calopedos, Albert Bang, Xue Qin Yu, Sam Egger, Suzanne Chambers, Dianne L O'Connell
BACKGROUND: An elevated risk of suicide after a diagnosis of prostate cancer has been reported previously in the USA and Sweden. We aimed to identify whether prostate cancer survivors resident in New South Wales Australia are at higher risk of suicide and if so, who is most at risk. METHODS: Data were obtained from the New South Wales (NSW) Cancer Registry for all men diagnosed with prostate cancer in NSW during 1997 to 2007. These were linked by the Centre for Health Record Linkage (CHeReL) to Australian Bureau of Statistics Mortality Data to the end of 2007 to determine vital status and cause of death...
2018: PloS One
https://www.readbyqxmd.com/read/29897569/a-high-abdominal-aortic-calcification-score-by-dual-x-ray-absorptiometry-is-associated-with-cardiovascular-events-after-kidney-transplantation
#18
Stan Benjamens, Robert A Pol, Andor W J M Glaudemans, Ivanka Wieringa, Stefan P Berger, Stephan J L Bakker, Riemer H J A Slart
Background: Aortic calcification is associated with an increased risk for cardiovascular events in renal transplant recipients. This study focused on the association of abdominal aortic calcification (AAC) and cardiovascular events assessed using a dual-energy X-ray absorptiometry (DXA) scoring methodology for AAC. Methods: From 2008 to 2014, renal transplant recipients referred for a DXA procedure within 6 months after transplantation were included in a retrospective, single-centre study...
June 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29897296/high-iliac-calcium-score-is-associated-with-increased-severity-and-complexity-of-peripheral-arterial-disease-and-predicts-global-atherosclerotic-burden
#19
Zsuzsanna Jeremias, Nora Rat, Imre Benedek, Emese Rapolti, Mihaela Ratiu, Adrian Muresan, Theodora Benedek
BACKGROUND: The role of vascular calcifications in iliac arteries for predicting global atherosclerotic burden in still unknown. The aim of this study was to investigate whether iliac calcium score (ICS), a new computed tomographic angiography (CTA) derived biomarker of vascular calcification, can predict the severity and complexity of peripheral arterial disease (PAD) as well as the global atherosclerotic burden. PATIENTS AND METHODS: This was a single centre, non-randomized, observational prospective study on 84 consecutive patients with symptomatic peripheral arterial disease, undergoing peripheral CTA examination of the lower limbs, divided into high (n = 42) and low ICS (n = 42) groups with a median value for ICS of 3934 HU...
June 13, 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29896570/extracapsular-excision-of-hepatic-hemangioma-a-single-centre-experience
#20
Amol Kanetkar, Shubham Garg, Shraddha Patkar, Rajesh S Shinde, Mahesh Goel
Backgrounds/Aims: Hepatic hemangioma is a common non-epithelial neoplasm of the liver. Presence of symptoms and uncertainty in diagnosis are the most common indications for surgery. Methods: Eighteen patients with hepatic hemangioma, operated on from January 2011 to December 2016 at the Hepato-pancreato-biliary surgical unit of Tata Memorial Hospital, were retrospectively analyzed. Results: Main indications for operation were presence of symptoms, the most common being pain and diagnostic uncertainty...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
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