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SAPHO syndrome

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https://www.readbyqxmd.com/read/27846749/synovitis-of-sternoclavicular-and-peripheral-joints-can-be-detected-by-ultrasound-in-patients-with-sapho-syndrome
#1
Masataka Umeda, Shin-Ya Kawashiri, Ayako Nishino, Tomohiro Koga, Kunihiro Ichinose, Toru Michitsuji, Toshimasa Shimizu, Shoichi Fukui, Yoshikazu Nakashima, Yasuko Hirai, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami
OBJECTIVES: To determine the prevalence of ultrasonographic abnormalities of sternoclavicular joints (SCJ) and peripheral joints (PJ) in patients with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. METHODS: Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP and the other symptomatic joints were evaluated by ultrasound (US)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27785852/severe-osteoarticular-involvement-in-isotretinoin-triggered-acne-fulminans-two-cases-successfully-treated-with-anakinra
#2
T Oranges, A Insalaco, A Diociaiuti, C Carnevale, R Strippoli, G Zambruno, P Tomà, M El Hachem
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia(1) . Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in synovitis - acne - pustulosis - hyperostosis and osteitis (SAPHO) syndrome(2,3) . SAPHO is an autoinflammatory disease characterized by osteoarticular and cutaneous manifestations, the latter including nodular and fulminans acne, hidroadenitis suppurativa, and palmo-plantar pustolosis(3) ...
October 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27742022/imaging-for-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome
#3
Steven Schaub, Hartley M Sirkis, Jonathan Kay
Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region classically yields a 'bull's head' pattern of radionuclide uptake. Magnetic resonance imaging (MRI) can demonstrate corner lesions of vertebral bodies...
November 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27730042/sapho-syndrome-with-acne-fulminans-and-severe-polyosteitis-involving-axial-skeleton
#4
B Lakshmi Divya, P Narasimha Rao
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27698770/multimodal-imaging-findings-of-sapho-syndrome-with-no-skin-lesions-a-report-of-three-cases-and-review-of-the-literature
#5
Na Duan, Xiao Chen, Yongkang Liu, Jianhua Wang, Zhongqiu Wang
Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27528491/-sapho-syndrome-a-case-of-a-patient-with-anterior-musculoskeletal-chest-pain-and-palmoplantar-pustulosis-treated-successfully-with-golimumab
#6
F Abadín López, E Revuelta Evrard
No abstract text is available yet for this article.
August 12, 2016: Semergen
https://www.readbyqxmd.com/read/27527220/sternocostoclavicular-hyperostosis-an-ill-recognized-disease
#7
Bolette Roed, Tatiana Kristensen, Søren Thorsen, Klaus Poulsen Bloch, Pia Afzelius
Sternocostoclavicular hyperostosis (SCCH) is an ill-recognized, rarely diagnosed disease. Today, SCCH is widely considered part of the synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. SCCH develops over years with intermittent attacks of pain, swelling, and reddening of the sternocostoclavicular region. The disease causes progressive hyperostosis, fusion of the sternocostoclavicular joints, and soft tissue ossification. SCCH is chronic, non-malignant, and occurs predominantly bilaterally in middle-aged women...
August 5, 2016: Diagnostics
https://www.readbyqxmd.com/read/27527149/serum-interleukin-18-fetuin-a-soluble-intercellular-adhesion-molecule-1-and-endothelin-1-in-ankylosing-spondylitis-psoriatic-arthritis-and-sapho-syndrome
#8
Hanna Przepiera-Będzak, Katarzyna Fischer, Marek Brzosko
To examine serum interleukin 18 (IL-18), fetuin-A, soluble intercellular adhesion molecule-1 (sICAM-1), and endothelin-1 (ET-1) levels in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and Synovitis Acne Pustulosis Hyperostosis Osteitis syndrome (SAPHO). We studied 81 AS, 76 PsA, and 34 SAPHO patients. We measured serum IL-18, fetuin-A, sICAM-1, ET-1, IL-6, IL-23, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). IL-18 levels were higher in AS (p = 0.001), PsA (p = 0.0003), and SAPHO (p = 0...
August 3, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27456988/interstitial-granulomatous-dermatitis-occurring-in-a-patient-with-sapho-syndrome-one-month-after-starting-leflunomide-and-subsequently-disappearing-with-ustekinumab
#9
Hélène Cornillier, Thibault Kervarrec, Flore Tabareau-Delalande, Saloua Mammou, Annie-Pierre Jonville Bera, Laurent Machet
No abstract text is available yet for this article.
July 25, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27399138/a-case-report-of-severely-damaged-hip-joint-caused-by-sapho-syndrome-treated-with-2-stage-total-hip-arthroplasty
#10
Ingwon Yeo, Hoon-Suk Cha, Young Cheol Yoon, Youn-Soo Park, Seung-Jae Lim
INTRODUCTION: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an increasingly recognized entity. The hip joint is known as a less frequently affected site in SAPHO syndrome, and there has been limited reports about hip joint diseases caused by SAPHO syndrome, and as such adequate treatment for this disease spectrum is still not fully elucidated. CASE: We describe the case of a 52-year-old man admitted for SAPHO syndrome who went on to be diagnosed with advanced secondary hip arthritis associated with disabling right hip pain...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27369452/sapho-treatment-options-including-bisphosphonates
#11
Tom Zwaenepoel, Kurt de Vlam
INTRODUCTION: Both the diagnosis and treatment of the syndrome of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) remain difficult. We describe a case series of 21 patients with SAPHO and their response to several pharmacological treatments. METHODS: Clinical and biochemical data, along with medical imaging, were collected from the medical records of 21 patients, diagnosed as SAPHO during follow-up between 2005 and 2013. Symptoms and inflammatory markers were recorded twice, once at first patient presentation, and once at the end of follow-up...
October 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27263075/synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome-a%C3%A2-challenging-diagnosis-not-to-be-missed
#12
Petra Zimmermann, Nigel Curtis
SAPHO syndrome manifests as chronic inflammation of bones and joints, which may or may not be accompanied by skin changes. The term SAPHO is an acronym that stands for synovitis, acne, pustulosis (usually palmoplantar), hyperostosis and osteitis. The bones most commonly affected are those in the anterior chest wall (mainly the sternum, clavicles and sternocostoclavicular joints), the vertebrae and the sacroiliac joints, but peripheral and flat bones may also be involved, especially in children. There are no validated diagnostic criteria for SAPHO, and diagnosis is based on clinical and radiological findings...
July 5, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27181039/bilateral-subclavian-vein-occlusion-in-a-sapho-syndrome-patient-who-needed-an-implantable-cardioverter-defibrillator
#13
Masato Ishizuka, Yuko Yamamoto, Shintaro Yamada, Sonoko Maemura, Ryo Nakata, Yoshihiro Motozawa, Keisuke Yamamoto, Masataka Takizawa, Hiroki Uozumi, Hiroshi Ikenouchi
A 79-year-old Asian man was hospitalized because of progressive exertional dyspnea with decreasing left ventricular ejection fraction and frequent non-sustained ventricular tachycardia. Pre-procedure venography for implantable cardioverter defibrillator (ICD) implantation showed occlusion of the bilateral subclavian veins. In consideration of subcutaneous humps in the sterno-clavicular area and palmoplantar pustulosis, we diagnosed him as having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome and speculated that it induced peri-osteal chronic inflammation in the sterno-clavicular area, resulting in occlusion of the adjacent bilateral subclavian veins...
May 25, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27121779/neutrophils-from-patients-with-sapho-syndrome-show-no-signs-of-aberrant-nadph-oxidase-dependent-production-of-intracellular-reactive-oxygen-species
#14
Per Wekell, Halla Björnsdottir, Lena Björkman, Martina Sundqvist, Karin Christenson, Veronica Osla, Stefan Berg, Anders Fasth, Amanda Welin, Johan Bylund, Anna Karlsson
OBJECTIVE: We aimed to investigate if aberrant intracellular production of NADPH oxidase-derived reactive oxygen species (ROS) in neutrophils is a disease mechanism in the autoinflammatory disease SAPHO syndrome, characterized by synovitis, acne, pustulosis, hyperostosis and osteitis, as has previously been suggested based on a family with SAPHO syndrome-like disease. METHODS: Neutrophil function was explored in a cohort of four patients with SAPHO syndrome, two of whom were sampled during both inflammatory and non-inflammatory phase...
August 2016: Rheumatology
https://www.readbyqxmd.com/read/27108452/sapho-syndrome-current-developments-and-approaches-to-clinical-treatment
#15
REVIEW
Davide Firinu, Vanessa Garcia-Larsen, Paolo Emilio Manconi, Stefano R Del Giacco
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. Treatments with immunosuppressive drugs have been used for the management of SAPHO with variable results. To date, the use of anti-TNF-α agents has proved to be an effective alternative to conventional treatment for unresponsive or refractory SAPHO cases...
June 2016: Current Rheumatology Reports
https://www.readbyqxmd.com/read/27106250/pyoderma-gangrenosum-and-its-syndromic-forms-evidence-for-a-link-with-autoinflammation
#16
REVIEW
A V Marzano, A Borghi, P L Meroni, M Cugno
Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis manifesting as painful ulcers with violaceous, undermined borders on the lower extremities. It may occur in the context of classic syndromes like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), as well as in a recently described entity named PASH (pyoderma gangrenosum, acne and suppurative hidradenitis). Pyoderma gangrenosum has recently been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies and autoreactive T cells...
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27058745/atypical-sapho-syndrome-with-isolated-manubriosternal-inflammation-a-multi-image-demonstration
#17
Do Kyun Kim, Ki Hoon Kim, Byung Kyu Park, Dong Hwee Kim
No abstract text is available yet for this article.
July 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27012293/sapho-syndrome-imaging-findings-of-vertebral-involvement
#18
A M McGauvran, A L Kotsenas, F E Diehn, J T Wald, C M Carr, J M Morris
BACKGROUND AND PURPOSE: Imaging findings in patients with a combination of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) are often misinterpreted as discitis/osteomyelitis or metastases, resulting in multiple biopsies and delayed diagnosis. We have incidentally noted a semicircular morphology in vertebral body imaging in several cases of SAPHO syndrome with vertebral involvement. Our goal was to evaluate the prevalence of this distinctive morphology in these patients...
August 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/26917545/synovitis-acne-pustulosis-hyperostosis-and-osteitis-syndrome-a-single-centre-study-of-a-cohort-of-164-patients
#19
Chen Li, Yuzhi Zuo, Nan Wu, Li Li, Feng Li, Weihong Zhang, Wenrui Xu, Xue Zhao, Hongli Jing, Qingqing Pan, Weixun Zhou, Xiaohua Shi, Yu Fan, Jianyi Wang, Sen Liu, Zhenlei Liu, Fengchun Zhang, Xiaofeng Zeng, Hui Chen, Siya Zhang, Jinhe Liu, Guixing Qiu, Zhihong Wu, Zhenhua Dong, Wen Zhang
OBJECTIVE: The aim was to assess the clinical, laboratory and radiological features of SAPHO syndrome. METHODS: We recruited all patients presenting to Peking Union Medical College Hospital from 2004 to 2015 diagnosed with SAPHO syndrome. The medical data, laboratory test results and imaging were collected for all patients. RESULTS: One hundred and sixty-four patients (111 women and 53 men) were recruited to our cohort. The mean age of the patients was 40...
June 2016: Rheumatology
https://www.readbyqxmd.com/read/26793990/sapho-syndrome-presenting-as-an-osteolytic-lesion-of-the-neck
#20
Lourdes Mateo, Juana Sanint, Samantha Rodríguez Muguruza, Melania Martínez Morillo, Ricard Pérez Andrés, Sira Domenech Puigcerver
We report a case of acute-onset multifocal vertebral osteitis with a marked impact on the patient's general health. The radiological, scintigraphic and magnetic resonance findings made it necessary to carry out a differential diagnosis to distinguish it from an infiltrative neoplastic process and determine whether it had an infectious or an inflammatory etiology. The presence of noninfectious multifocal osteitis and sternoclavicular arthritis and the subsequent development of plantar pustulosis pointed to SAPHO syndrome...
January 11, 2016: Reumatología Clinica
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