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JOURNAL ARTICLE
Ruthika S Patil, Pradeep Onteru, Janmajay Jena, Chapala Shashank, Humera Siddiqua, Hiral A Parikh, Heena Dixit Tiwari
INTRODUCTION: The onset and maintenance of disease can be significantly influenced by the colonization of the mouth cavity by pathogenic microorganisms or by an imbalance of the physiological microbiome. Hence, in the current study, various commonly used antibiotics have been tested for their antibacterial and antifungal activity. MATERIALS AND METHODS: The current research was performed as an in vitro study. The commonly used antibiotics Augmentin (CV), Ceftriaxone-Cephalosporin (CF), and Linezolid were tested for the microorganisms, lactobacillus, and Escherichia coli ...
February 2024: Journal of Pharmacy & Bioallied Sciences
#22
JOURNAL ARTICLE
Bo-Gyeong Jeong, Myeong-Yeon Kim, Chang-Sook Jeong, Hackwon Do, Jisub Hwang, Jun Hyuck Lee, Sun-Shin Cha
Stenotrophomonas spp. intrinsically resistant to many β-lactam antibiotics are found throughout the environment. CESS-1 identified in Stenotrophomonas sp. KCTC 12332 is an uncharacterized class A β-lactamase. Here, CESS-1 was revealed to display hydrolytic activities toward penicillins (penicillin G and ampicillin) and cephalosporins (cephalexin, cefaclor, and cefotaxime), while its activity toward carbapenems (imipenem and meropenem) was negligible. Although cefaclor, cephalexin, and ampicillin have similar structures with identical R1 side chains, the catalytic parameters of CESS-1 toward the three β-lactam antibiotics were distinct...
April 6, 2024: International Journal of Antimicrobial Agents
#23
JOURNAL ARTICLE
Semiha Çelik Ekinci, Ercan Yenilmez, Gülfem Akengin Öcal, Meliha Çağla Sönmezer, Arzu Tarakçı, Cemanur Aygün, Damla Akdağ, Derya Seyman, Cansu Aşık, Esra Zerdali, Fatma Yılmaz Karadağ, Şafak Kaya, Mehmet Çelik, Şeyma Çifci, İlknur Esen Yıldız, Fatma Çölkesen, Fethiye Akgül, Özlem Aldemir, Merve Bozdağ, Deniz Özer, Lokman Hızmalı, Esra Canbolat Ünlü, Deniz Gür Altunay, Ahmet Şahin, Gülten Ünlü, Ayşe Eda Gençalioğlu, Sema Tekin Şahin, Yeliz Özdemir, Sibel Ünlü, Sarp Singil, Jale Altıntaş, Sinem Akkaya Işık, Özlem Gül, Nazan Tuna, Sümeyra Şimşek, Müge Özgüler, Pınar Elbir Kılıç, Mehmet Emirhan Işık, Ayşe Karakuş, Kazım Kıratlı, Ahmet Cem Yardımcı, Serkan Volkan, Yıldız Olçar, Yasemin Çakır, Nermin Özer Yılmaz, Serhat Karaayvaz, Ayşe Batırel, Zeynep Cansu Duran, Hüseyin Kemal Raşa, Şükran Köse
Background: Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%. The aim of this multicenter study was to determine the rate of appropriate antibiotic class, timing, and duration as well as discharge prescriptions in Turkey. Thus, we aimed to determine the rate of full compliance with SAP procedures in our country Patients and Methods: This multicenter, prospective, observational, descriptive study was conducted in 47 hospitals from 28 provinces in seven different regions of Turkey...
April 2024: Surgical Infections
#24
JOURNAL ARTICLE
Ana Abad-Fau, Eloisa Sevilla, Ainara Oro, Inmaculada Martín-Burriel, Bernardino Moreno, Mariano Morales, Rosa Bolea
Escherichia coli ( E. coli ) is a pathogen frequently isolated in cases of urinary tract infections (UTIs) in both humans and dogs and evidence exists that dogs are reservoirs for human infections. In addition, E. coli is associated to increasing antimicrobial resistance rates. This study focuses on the analysis of antimicrobial resistance and the presence of selected virulence genes in E. coli isolates from a Spanish dog population suffering from UTI. This collection of isolates showed an extremely high level of phenotypic resistance to 1st-3rd generation cephalosporins, followed by penicillins, fluoroquinolones and amphenicols...
2024: Frontiers in Veterinary Science
#25
JOURNAL ARTICLE
Rita Fernandes, Raquel Abreu, Isa Serrano, Roger Such, Encarnación Garcia-Vila, Sandy Quirós, Eva Cunha, Luís Tavares, Manuela Oliveira
This study aimed to characterize the antimicrobial resistance (AMR) and virulence profiles of 67 Escherichia coli isolates obtained from faecal samples of 77 wild mammals from 19 different species, admitted in two rescue and rehabilitation centers in Costa Rica. It was possible to classify 48% (n = 32) of the isolates as multidrug-resistant, and while the highest resistance levels were found towards commonly prescribed antimicrobials, resistance to fluoroquinolones and third generation cephalosporins were also observed...
April 5, 2024: Scientific Reports
#26
JOURNAL ARTICLE
Raffaele Scarpellini, Laura Leal Vélez De Mendizábal, Sergio Quevedo-Caraballo, José L Blanco, Marta E García, Marta Pérez-Sancho, Miriam Portero Fuentes, Silvia Penelo, Erika Esposito, Elisabetta Mondo, Silvia Piva
The role of small animal veterinary hospitals in the onset and dissemination of antimicrobial-resistant organisms (AMROs) is still not clear, and the implementation of an internal surveillance systems is a cost-effective tool to better understand their impact. The aim of this study was to describe a pilot program of active surveillance in a Spanish Veterinary Teaching Hospital, developed to estimate the detection frequency of AMROs in the commensal flora of patients and in the environment. Surveillance was focused on Methicillin-resistant Staphylococci (MRS), third generation cephalosporins resistant gram-negative bacteria (3GCR-GNB), and carbapenems-resistant gram-negative bacteria (CR-GNB)...
April 2, 2024: Comparative Immunology, Microbiology and Infectious Diseases
#27
JOURNAL ARTICLE
Divisha Sharma, Zoheb I Sulaiman, Patrick J Tu, Sean Harrell, Stuart Cavalieri, Peter J Skidmore, Stephanie L Baer
Citrobacter koseri (formerly classified as Citrobacter diversus ) is a gram-negative bacillus (GNB) that occurs as an opportunistic pathogen in neonates and immunocompromised patients. Citrobacter species have been implicated in nosocomial settings leading to infections involving the urinary tract, respiratory tract, liver, biliary tract, meninges, and even in rarer conditions-blood stream infection and infective endocarditis (IE). Gram-negative bacilli are responsible for 3% to 4% of all IE cases and have been traditionally associated with intravenous drug users...
2024: Journal of Investigative Medicine High Impact Case Reports
#28
JOURNAL ARTICLE
Venkataramana Kandi, Praveen R Shahapur, Tarun Kumar Suvvari, Vallab Ganesh Bharadwaj, Chitra Rajalakshmi P, Roopa Shahapur, Eswar Podaralla, Vikram Godishala
Introduction An enormous increase in antimicrobial resistance (AMR) among bacteria isolated from human clinical specimens contributed to treatment failures. Increased surveillance through next-generation sequencing (NGS) or whole genome sequencing (WGS) could facilitate the study of the epidemiology of drug-resistant bacterial strains, resistance genes, and other virulence determinants they are potentially carrying. Methods This study included 30 Escherichia coli ( E . coli ) isolates obtained from patients suffering from urinary tract infections (UTIs) attending Prathima Institute of Medical Sciences, Karimnagar, India...
March 2024: Curēus
#29
JOURNAL ARTICLE
Getahun E Agga, Lisa M Durso, Karamat R Sistani
Given the high cost and non-renewability of mineral-based fertilizers, there is increasing interest in the innovative use of manure-based materials, such as poultry litter (PL). However, manure-based fertilizers add both nutrients and microbes to the soil, including antibiotic-resistant Escherichia coli (AREc). PL soil amendment impact on AREc in corn fields was evaluated in a randomized field experiment (May-October 2017). Two winter cropping systems (fallow and cover crop) were assigned to whole plots, with three spring-applied fertilizer treatments (untreated control [UC], PL, and commercial fertilizer [CF]) assigned to subplots...
April 4, 2024: Journal of Environmental Quality
#30
JOURNAL ARTICLE
Buhari Teker, Maarten Schim van der Loeff, Elske Hoornenborg, Anders Boyd, Sophia Reedijk, Alje van Dam, Vita Willemijn Jongen, Henry de Vries
OBJECTIVES: International travel combined with sex may contribute to dissemination of antimicrobial-resistant (AMR) Neisseria gonorrhoeae (Ng). To assess the role of travel in Ng strain susceptibility, we compared minimum inhibitory concentrations (MICs) for five antibiotics (ie, azithromycin, ceftriaxone, cefotaxime, cefixime and ciprofloxacin) in strains from clients with an exclusively Dutch sexual network and clients with an additional international sexual network. METHODS: From 2013 to 2019, we recorded recent residence of sexual partners of clients (and of their partners) with Ng at the Center for Sexual Health of Amsterdam...
April 4, 2024: Sexually Transmitted Infections
#31
JOURNAL ARTICLE
Hanna Schmid, Li-An K Brown, Bairavi Indrakumar, Orlagh McGarrity, James Hatcher, Alasdair Bamford
Cefiderocol, a novel siderophore cephalosporin, represents a treatment option for infections with multidrug-resistant Gram-negative bacteria, of which rates are rising worldwide. Clinical data on its use in children is limited. In our pediatric case series, the largest reported to date, cefiderocol seems safe and well tolerated, with more favorable clinical outcomes when compared to the literature reviewing adult cases.
April 2, 2024: Pediatric Infectious Disease Journal
#32
Xusheng Gao, Caihong Ding, Dan Xie, Qing Wang, Peipei Jiang, Yuyu Wang, Yu Xiong
BACKGROUND: In recent decades, there has been a substantial surge in the incidence of non-tuberculous Mycobacteria (NTM) infections. However, the diagnosis and management of NTM globally present significant challenges, particularly in cases involving Mycobacterium abscessus complex (MABC) infection where effective therapeutic options are limited. CASE PRESENTATION: We reported a 38-year-old female patient who was infected with MABC of skin due to "beauty needle" at a beauty salon, with mass on both cheeks, accompanied by redness, and pain, and some of them was ulcered and effused...
2024: Infection and Drug Resistance
#33
JOURNAL ARTICLE
Eric G Romanowski, Sonya M Mumper, Hazel Q Shanks, Kathleen A Yates, Jonathan B Mandell, Michael E Zegans, Robert M Q Shanks
PURPOSE: To test cefiderocol, a siderophore-cephalosporin antibiotic for topical monotherapy treatment of experimental extensively drug-resistant (XDR) Pseudomonas aeruginosa keratitis. DESIGN: Preclinical study. SUBJECTS AND CONTROLS: Deidentified P. aeruginosa keratitis isolates, XDR P. aeruginosa from eye drop outbreak, rabbits, saline, cefiderocol 50 mg/ml, ciprofloxacin 0.3%, and tobramycin 14 mg/ml. METHODS INTERVENTION OR TESTING: Cefiderocol antibacterial activity against P...
2024: Ophthalmol Sci
#34
JOURNAL ARTICLE
Feng Tang, Changzhen Li, Ran Li, Lei Xi, Fang Wang, Juling Tian, Wanjun Luo
The urgent need for comprehensive and systematic analyses of Shigella as the key pathogen led us to meticulously explore the epidemiology and molecular attributes of Shigella isolates. Accordingly, we procured 24 isolates (10 from Xinjiang and 14 from Wuhan, China) and performed serotype identification and antimicrobial susceptibility testing. Resistance gene detection and homology analysis by polymerase chain reaction and pulsed-field gel electrophoresis (PFGE), respectively, were performed for genetic diversity analysis...
April 1, 2024: Foodborne Pathogens and Disease
#35
JOURNAL ARTICLE
Tsolaire Sourenian, Jana Palkovicova, Costas C Papagiannitsis, Monika Dolejska, Jaroslav Hrabak, Ibrahim Bitar
OBJECTIVE: Here we describe a novel IncFIA plasmid harboring mcr-10 gene in a clinical Enterobacter ludwigii strain isolated at the University Hospital in Pilsen in the Czech Republic. METHODS: The strain was subjected to antibiotic susceptibility testing. Whole genome sequencing was performed using Illumina for short read sequencing and Oxford Nanopore Technologies for long-read sequencing followed by hybrid assembly. The resulting genome was used to detect species using average nucleotide identity, resistance genes, plasmid replicon and MLST (using center for genomic epidemiology databases; ResFinder, PlasmidFinder and MLST repsectively) and virulence genes using VFDB...
March 28, 2024: Journal of Global Antimicrobial Resistance
#36
JOURNAL ARTICLE
Hokyung Song, Jung Sik Yoo, Tatsuya Unno
Extended-spectrum beta-lactamase (ESBL)-producing bacteria are resistant to most beta-lactams, including third-generation cephalosporins, limiting the treatment methods against the infections they cause. In this study, we performed whole genome sequencing of ESBL-producing E. coli to determine the mechanisms underlying the dissemination of antibiotic resistance genes. We analyzed 141 ESBL-producing isolates which had been collected from 16 veterinary clinics and 16 farms in South Korea. Long- and short-read sequencing platforms were used to obtain high-quality assemblies...
March 28, 2024: Science of the Total Environment
#37
JOURNAL ARTICLE
Yuliya Aleshina, Anara Yeleussizova, Anara Mendybayeva, Pavel Shevchenko, Raushan Rychshanova
BACKGROUND: An increasing number of drugs are used each year in the treatment of small pets (cats and dogs), including medicines (cephalosporins and fluoroquinolones) used in human therapy. AIM: The purpose of this study was to isolate and explore the antibiotic resistance of opportunistic Enterobacteriaceae ( Escherichia coli , Klebsiella, Proteus, Ci trobacter, Enterobacter ) from cats and dogs, and to isolate resistance genes in the microorganisms. METHODS: In 2021, 808 samples of biological material from small domestic animals were collected in veterinary clinics in Kostanay...
February 2024: Open Veterinary Journal
#38
JOURNAL ARTICLE
M Pirolo, M Menezes, M Poulsen, V Søndergaard, P Damborg, A C Poirier, R La Ragione, M Schjærff, L Guardabassi
Staphylococcus pseudintermedius is the most common cause of pyoderma in dogs. We validated a point-of-care (PoC) test based on colorimetric loop-mediated isothermal amplification (LAMP) for rapid S. pseudintermedius identification and susceptibility testing for first line antimicrobials for systemic treatment of canine pyoderma, i.e., lincosamides, first generation cephalosporins and amoxicillin clavulanate. Newly designed LAMP primers targeting clinically relevant resistance genes were combined with a previously validated set of primers targeting spsL for species identification...
March 26, 2024: Veterinary Journal
#39
JOURNAL ARTICLE
Sarah E Sansom, Teppei Shimasaki, Thelma Dangana, Michael Y Lin, Michael E Schoeny, Christine Fukuda, Nicholas M Moore, Rachel D Yelin, Christine M Bassis, Yoona Rhee, Enrique Cornejo Cisneros, Pamela Bell, Karen Lolans, Khaled Aboushaala, Vincent B Young, Mary K Hayden
BACKGROUND: Admission and discharge screening of patients for asymptomatic gut colonization with multidrug-resistant organisms (MDROs) is a traditional approach to active surveillance, but its sensitivity for detecting colonization is uncertain. METHODS: Daily rectal or fecal swab samples and clinical data were collected over 12 months from patients in one 25-bed intensive care unit (ICU) in Chicago, IL USA and tested for the following multidrug-resistant organisms (MDROs): vancomycin-resistant enterococci (VRE); third-generation cephalosporin-resistant Enterobacterales, including extended-spectrum β-lactamase-producing Enterobacterales (ESBL); and carbapenem-resistant Enterobacterales (CRE)...
March 28, 2024: Journal of Infectious Diseases
#40
Manish Shrestha, Devi Parvathy Jyothi Ramachandran Nair, Shefali Amin, Arpan Pokhrel, Salina Munankami
Ureaplasma species, typically considered commensal organisms of the human urogenital tract, have been implicated in various urinary tract infections (UTIs), including the rare and challenging presentation of pyelonephritis. This case report describes a unique instance of pyelonephritis induced by Ureaplasma , characterized by a negative routine urine culture and a lack of response to empirical antibiotic treatment, highlighting the complexities associated with diagnosing and managing infections caused by atypical pathogens...
February 2024: Curēus
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