keyword
MENU ▼
Read by QxMD icon Read
search

cephalosporin resistance

keyword
https://www.readbyqxmd.com/read/29040595/a-comparison-of-levofloxacin-and-oral-third-generation-cephalosporins-as-antibacterial-prophylaxis-in-acute-leukaemia-patients-during-chemotherapy-induced-neutropenia
#1
Kristyn E Yemm, Jason N Barreto, Kristin C Mara, Ross A Dierkhising, Naseema Gangat, Pritish K Tosh
Background: There is demonstrated benefit with fluoroquinolones as infection prophylaxis in neutropenic patients; however, side effects, drug interactions and increasing resistance necessitate investigation of alternative therapies. Objectives: To compare the incidence of febrile neutropenia in high-risk patients with haematological malignancy receiving a fluoroquinolone with those receiving an oral third-generation cephalosporin (OTGC) as antibacterial prophylaxis during chemotherapy-induced neutropenia...
October 11, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29040419/high-rates-of-human-fecal-carriage-of-mcr-1-positive-multi-drug-resistant-enterobacteriaceae-isolates-emerge-in-china-in-association-with-successful-plasmid-families
#2
Lan-Lan Zhong, Hang T T Phan, Cong Shen, Karina Doris-Vihta, Anna E Sheppard, Xi Huang, Kun-Jiao Zeng, Hong-Yu Li, Xue-Fei Zhang, Sandip Patil, Derrick W Crook, A Sarah Walker, Yong Xing, Jia-Lin Lin, Lian-Qiang Feng, Yohei Doi, Yong Xia, Nicole Stoesser, Guo-Bao Tian
Objectives: mcr-1-mediated colistin resistance in Enterobacteriaceae is concerning, as colistin is used in treating multidrug-resistant Enterobacteriaceae infections. Rates of human mcr-1 gastrointestinal carriage have historically been low. We identified trends in human fecal mcr-1-positivity rates and colonization with mcr-1-positive+third-generation cephalosporin-resistant (3GC-R) Enterobacteriaceae in Guangzhou, China, and investigated the genetic contexts of mcr-1 in a subset of mcr-1-positive+3GC-R strains...
October 10, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29031106/new-insights-into-resistance-to-colistin-and-third-generation-cephalosporins-of-escherichia-coli-in-poultry-portugal-novel-blactx-m-166-and-blaesac-genes
#3
Vera Manageiro, Lurdes Clemente, Rafael Graça, Ivone Correia, Teresa Albuquerque, Eugénia Ferreira, Manuela Caniça
The increasing incidence of intestinal colonization with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae and Gram negative organisms that has been observed in food animals such as poultry, cattle and pigs, are suggestive that animals, food and environment are potential sources of ESBL-producing bacteria. Hence, the aim of this study was to characterized commensal E. coli obtained from healthy broiler and turkey flocks at slaughter for the presence of penicillinases-, ESBL-, extended-spectrum AmpC (ESAC)-, plasmid-mediated quinolone resistance- and MCR-encoding genes...
October 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29029149/no-clinical-benefit-of-empirical-antimicrobial-therapy-for-pediatric-diarrhea-in-a-high-usage-high-resistance-setting
#4
Vu Thuy Duong, Ha Thanh Tuyen, Pham Van Minh, James I Campbell, Hoang Le Phuc, Tran Do Hoang Nhu, Le Thi Phuong Tu, Tran Thi Hong Chau, Le Thi Quynh Nhi, Nguyen Thanh Hung, Nguyen Minh Ngoc, Nguyen Thi Thanh Huong, Lu Lan Vi, Corinne N Thompson, Guy E Thwaites, Ruklanthi de Alwis, Stephen Baker
Background: Pediatric diarrheal disease presents a major public health burden in low-middle income countries. The clinical benefits of empirical antimicrobial treatment for diarrhea are unclear in settings that lack reliable diagnostics and have high antimicrobial resistance (AMR). Methods: We conducted a prospective multi-center cross-sectional study of pediatric patients hospitalized with diarrhea containing blood and/or mucus in Ho Chi Minh City, Vietnam. Clinical parameters, including disease outcome and treatment, were measured...
September 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29028276/enhancing-antibiotic-stewardship-by-tackling-spurious-penicillin-allergy
#5
Mamidipudi Thirumala Krishna, Aarnoud P Huissoon, Mark Li, Alex Richter, Devadas Ganesh Pillay, Dhinakaran Sambanthan, Sumanth C Raman, Shuaib Nasser, Siraj A Misbah
Approximately 90-99% of patients with a label of penicillin allergy (PenA) are not allergic when comprehensively investigated. An inaccurate label of PenA has major public health implications - longer hospital stay, more frequent hospital admissions, greater use of fluoroquinolones, glycopeptides, cephalosporins and other expensive antibiotics resulting in significantly higher costs to the health service and predisposing to Clostridium difficile, meticillin-resistant Staphylococcus aureus infections and vancomycin resistant enterococcus...
October 13, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29023567/carbapenem-resistant-enterobacteriaceae-colonization-cre-and-subsequent-risk-of-infection-and-90-day-mortality-in-critically-ill-patients-an-observational-study
#6
Thomas Howe McConville, Sean Berger Sullivan, Angela Gomez-Simmonds, Susan Whittier, Anne-Catrin Uhlemann
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) have emerged as an urgent public health threat. Intestinal colonization with CRE has been identified as a risk factor for the development of systemic CRE infection, but has not been compared to colonization with third and/or fourth generation cephalosporin-resistant (Ceph-R) Enterobacteriaceae. Moreover, the risk conferred by colonization on adverse outcomes is less clear, particularly in critically ill patients admitted to the intensive care unit (ICU)...
2017: PloS One
https://www.readbyqxmd.com/read/29021722/bacterial-and-antimicrobial-susceptibility-profile-and-the-prevalence-of-sepsis-among-burn-patients-at-the-burn-unit-of-cipto-mangunkusumo-hospital
#7
A Wardhana, R Djan, Z Halim
Infection is a major cause of mortality and morbidity among burn patients. An effective measure to reduce infection is routine monitoring of bacterial infection and antimicrobial susceptibility patterns at the burn unit. This will help to create a burn centre-specific empirical antibiotic therapy protocol. A retrospective, descriptive study was conducted at the Cipto Mangunkusumo Hospital (RSCM) Burn Unit between September-November 2016. Data regarding bacterial culture isolates, antimicrobial susceptibility spectrum, and the number of burn patients diagnosed with sepsis were collected...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29020404/colistin-vs-ceftazidime-avibactam-in-the-treatment-of-infections-due-to-carbapenem-resistant-enterobacteriaceae
#8
David van Duin, Judith J Lok, Michelle Earley, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Yohei Doi, Keith S Kaye, Vance G Fowler, David L Paterson, Robert A Bonomo, Scott Evans
Background: The efficacy of ceftazidime-avibactam - a cephalosporin-β-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase (KPC)-producing carbapenem-resistant Enterobacteriaceae (CRE) - as compared to colistin remains unknown. Methods: Patients initially treated with either ceftazidime-avibactam or colistin for CRE infections were selected from the Consortium on resistance against carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), a prospective, multicenter, observational study...
September 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020310/levofloxacin-prophylaxis-during-induction-therapy-for-pediatric-acute-lymphoblastic-leukemia
#9
Joshua Wolf, Li Tang, Patricia M Flynn, Ching-Hon Pui, Aditya H Gaur, Yilun Sun, Hiroto Inaba, Tracy Stewart, Randall T Hayden, Hana Hakim, Sima Jeha
Background: Infection is the most important cause of treatment-related morbidity and mortality in pediatric patients treated for acute lymphoblastic leukemia (ALL). Although routine in adults with leukemia, antibacterial prophylaxis is controversial in pediatrics because of insufficient evidence for its efficacy or antibiotic choice and concerns about promoting antibiotic resistance and Clostridium difficile infection. Methods: This was a single-center, observational cohort study of patients with newly diagnosed ALL, comparing prospectively collected infection-related outcomes in patients who received no prophylaxis, levofloxacin prophylaxis, or other prophylaxis during induction therapy on the total XVI study...
September 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020273/the-transmissibility-of-antibiotic-resistant-enterobacteriaceae-in-intensive-care-units
#10
Tanya Gurieva, Mirjam J D Dautzenberg, Marek Gniadkowski, Lennie P G Derde, Marc J M Bonten, Martin C J Bootsma
Background: The global emergence of infections caused by Enterobacteriaceae resistant to expanded-spectrum cephalosporins (ESCs) in intensive care units (ICUs) is, at least partly, driven by cross-transmission. Yet, individual transmission capacities of bacterial species have not been quantified. Methods: In this post-hoc analysis of a multicenter study in 13 European ICUs prospective surveillance data and a mathematical model were used to estimate transmission capacities and single admission reproduction numbers (RA) of Escherichia coli and non-E...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020219/epidemiology-and-antimicrobial-resistance-characteristics-of-the-st131-h30-subclone-among-extraintestinal-escherichia-coli-collected-from-us-children
#11
Arianna Miles-Jay, Scott J Weissman, Amanda L Adler, Veronika Tchesnokova, Evgeni V Sokurenko, Janet G Baseman, Danielle M Zerr
Background: E. coli ST131-H30 is a globally important pathogen implicated in rising rates of multidrug resistance among E. coli causing extraintestinal infections. Previous studies have focused on adults, leaving the epidemiology of H30 among children undefined. Methods: We used clinical data and isolates from a case-control study of extended-spectrum cephalosporin-resistant E. coli conducted at four US children's hospitals to estimate the burden and identify host correlates of infection with H30...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020162/successful-therapy-of-a-multi-resistant-ebsl-shv-12-producing-and-fluoroquinolone-resistant-salmonella-enterica-subsp-enterica-serovar-typhi-infection-using-combination-therapy-of-meropenem-and-fosfomycin
#12
Carola-Ellen Kleine, Stefan Schlabe, Gunnar T R Hischebeth, Ernst Molitor, Yvonne Pfeifer, Jan-Christian Wasmuth, Ulrich Spengler
We report a traveler who aquired a Salmonella enterica subsp. enterica serovar Typhi strain with resistance against beta-lactams, cephalosporins (ESBL-SHV-12) and quinolones (PMQR qnrB7). After clinical deterioration using meropenem-monotherapy treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multi-resistant S.Typhi.
July 27, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017750/trends-and-relationship-between-antimicrobial-resistance-and-antibiotic-use-in-xinjiang-uyghur-autonomous-region-china-based-on-a-3-year-surveillance-data-2014-2016
#13
Haishaerjiang Wushouer, Zhao-Xia Zhang, Jian-Hua Wang, Ping Ji, Qing-Fang Zhu, Renagu Aishan, Lu-Wen Shi
PURPOSES: The objective of the study was to identify the trends and relations between antimicrobial resistance (AMR) and antibiotic use in the Xinjiang Uyghur Autonomous Region in Western China from 2014 to 2016. METHODS: A retrospective, descriptive analysis of AMR prevalence, and trends and relations between AMR and antibiotic use during the 3-year period was performed. RESULTS: Third-generation cephalosporin-resistant Escherichia coli was the most prevalent resistant pathogen in terms of both resistance density and resistance proportion...
October 7, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28993143/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-health-care-associated-infections-in-the-asia-pacific-region-apac-minus-china-australia-and-new-zealand-report-from-an-antimicrobial-surveillance-program
#14
M A Pfaller, D Shortridge, H S Sader, M Castanheira, R K Flamm
OBJECTIVES: To evaluate the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Enterobacteriaceae and Pseudomonas aeruginosa isolates from patients in the Asia-Pacific region (APAC) with health care associated infections (HAI). Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. METHODS: A total of 1,963 gram-negative organisms (489 P. aeruginosa and 1,474 Enterobacteriaceae) were consecutively collected using a prevalence-based approach from 14 medical centers in the APAC region...
October 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28993064/antimicrobial-susceptibility-of-microorganisms-that-cause-urinary-tract-infections-in-pediatric-patients
#15
Jesús Rodríguez-Lozano, Ana de Malet, María Eliecer Cano, Luis de la Rubia, Reinhard Wallmann, Luis Martínez-Martínez, Jorge Calvo
INTRODUCTION: Cumulative susceptibility reports are a valuable tool for the empirical treatment of urinary tract infections, especially in the current context of increasing resistance rates. Our objective was to analyze the antimicrobial susceptibility of bacterial isolates in urine cultures of pediatric patients during a five-year period. METHODS: Retrospective study of urine cultures from 2011 to 2015. Identification and antimicrobial susceptibility tests were performed using the Vitek-2 system (BioMérieux(®)) and categorized according to EUCAST criteria...
October 6, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28992919/genotypic-and-epidemiologic-characterization-of-extended-spectrum-cephalosporin-resistant-salmonella-enterica-from-us-beef-feedlots
#16
D F Mollenkopf, D A Mathys, D A Dargatz, M M Erdman, G G Habing, J B Daniels, T E Wittum
In the US, nontyphoidal Salmonellae are a common foodborne zoonotic pathogen causing gastroenteritis. Invasive Salmonella infections caused by extended-spectrum cephalosporin resistant (ESCR) phenotypes are more likely to result in treatment failure and adverse health outcomes, especially in severe pediatric Salmonella infections where the extended-spectrum β-lactams are the therapy of choice. To examine the genetic and epidemiologic characteristics of ESCR Salmonellae which may enter the food chain, we characterized 44 ceftiofur-resistant Salmonella isolates from the National Animal Health Monitoring System (NAHMS) 2011 beef cattle feedlot health and management study...
October 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28992133/intestinal-carriage-of-third-generation-cephalosporin-resistant-and-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-healthy-us-children
#17
Shamim Islam, Rangaraj Selvarangan, Neena Kanwar, Rendie McHenry, James D Chappell, Natasha Halasa, Mary E Wikswo, Daniel C Payne, Parvin H Azimi, L Clifford McDonald, Oscar G Gomez-Duarte
Background: The epidemiology of antibiotic-resistant Enterobacteriaceae intestinal carriage in healthy US children has not been well characterized. Methods: Children between 14 days and 14 years of age were enrolled during well-child visits in Oakland, California, Kansas City, Kansas, and Nashville, Tennessee, between December 2013 and March 2015. Data on recent antibiotic use by the child and travel and hospitalization history of all members of each child's household were obtained with a risk-factor survey...
June 15, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28991759/the-importance-of-perioperative-prophylaxis-with-cefuroxime-or-ceftriaxone-in-the-surgical-site-infections-prevention-after-cranial-and-spinal-neurosurgical-procedures
#18
Aleksandra Dimovska-Gavrilovska, Aleksandar Chaparoski, Andreja Gavrilovski, Zvonko Milenkovikj
Introduction Surgical site infections pose a significant problem in the treatment of neurosurgical procedures, regardless of the application of perioperative prophylaxis with systemic antibiotics. The infection rate in these procedures ranges from less than 1% to above 15%. Different antibiotics and administration regimes have been used in the perioperative prophylaxis so far, and there are numerous comparative studies regarding their efficiency, however, it is generally indicated that the choice thereof should be based on information and local specifics connected to the most probable bacterial causers, which would possibly contaminate the surgical site and cause infection, and moreover, the mandatory compliance with the principles of providing adequate concentration of the drug at the time of the anticipated contamination...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28987573/risk-assessment-modelling-of-fecal-shedding-caused-by-extended-spectrum-cephalosporin-resistant-escherichia-coli-transmitted-through-waste-milk-fed-to-dairy-pre-weaned-calves
#19
Babafela B Awosile, Ben A Smith
Waste milk feeding is a common practice in dairy operations. Regardless of the benefits of this practice to the dairy farmers, concerns from the potential dissemination of antimicrobial-resistant bacteria through the gut and subsequent shedding by calves into the environment are increasing. In this study, we employed Monte Carlo simulation to assess the risk of shedding extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R E. coli) caused by waste milk feeding in pre-weaned calves using an exponential dose-response model fit to data for E...
October 4, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28982134/a-rapid-diagnostic-workflow-for-cefotaxime-resistant-escherichia-coli-and-klebsiella-pneumoniae-detection-from-blood-cultures-by-maldi-tof-mass-spectrometry
#20
Elena De Carolis, Silvia Paoletti, Domenico Nagel, Antonietta Vella, Enrica Mello, Ivana Palucci, Giulia De Angelis, Tiziana D'Inzeo, Maurizio Sanguinetti, Brunella Posteraro, Teresa Spanu
BACKGROUND: Nowadays, the global spread of resistance to oxyimino-cephalosporins in Enterobacteriaceae implies the need for novel diagnostics that can rapidly target resistant organisms from these bacterial species. METHODS: In this study, we developed and evaluated a Direct Mass Spectrometry assay for Beta-Lactamase (D-MSBL) that allows direct identification of (oxyimino)cephalosporin-resistant Escherichia coli or Klebsiella pneumoniae from positive blood cultures (BCs), by using the matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) technology...
2017: PloS One
keyword
keyword
56998
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"