keyword
MENU ▼
Read by QxMD icon Read
search

Meckels

keyword
https://www.readbyqxmd.com/read/28812679/meckel-s-cartilage-breakdown-offers-clues-to-mammalian-middle-ear-evolution
#1
Neal Anthwal, Daniel J Urban, Zhe-Xi Luo, Karen E Sears, Abigail S Tucker
A key transformation in mammalian ear evolution was incorporation of the primary jaw joint of premammalian synapsids into the definitive mammalian middle ear of living mammals. This evolutionary transition occurred in two steps, starting with a partial or 'transitional' mammalian middle ear in which the ectotympanic and malleus were still connected to the mandible by an ossified Meckel's cartilage (MC), as observed in many Mesozoic mammals. This was followed by MC breakdown, freeing the ectotympanic and the malleus from the mandible and creating the definitive mammalian middle ear...
March 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812468/the-first-reported-case-of-meckel-gruber-syndrome-associated-with-abnormal-karyotype-mosaic-trisomy-17
#2
Zuzana Cierna, Pavol Janega, Frantisek Grochal, Vladimir Ferianec, Tatiana Braxatorisova, Lucia Strieskova, Jana Malova, Petra Jungova, Tomas Szemes
Meckel-Gruber syndrome (MKS) is a rare lethal autosomal recessive disorder with typical anomalies including encephalocele, multicystic renal dysplasia, congenital liver fibrosis, and polydactyly. MKS is caused by mutations of genes localized on different chromosomes. Karyotypes of published Meckel-Gruber syndrome cases are without any aberrations. We present a male fetus with meningoencephalocele, multicystic renal dysplasia, congenital liver fibrosis, and other anomalies. Standard cytogenetic examination of cultured fetal skin and muscle fibroblasts showed mosaic trisomy 17...
September 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28811097/type-i-collagen-promotes-primary-cilia-growth-through-down-regulating-hdac6-mediated-autophagy-in-confluent-mouse-embryo-fibroblast-3t3-l1-cells
#3
Qian Xu, Weiwei Liu, Xiaoling Liu, Wuxiyar Otkur, Toshihiko Hayashi, Masayuki Yamato, Hitomi Fujisaki, Shunji Hattori, Shin-Ichi Tashiro, Takashi Ikejima
Primary cilia are microtubule-based organelles that extend from nearly all vertebrate cells. Abnormal ciliogenesis and cilia length are suggested to be associated with hypertension and obesity as well as diseases such as Meckel-Gruber syndrome. Extracellular matrix (ECM), comprising cellular microenvironment, influences cell shape and proliferation. However, influence of ECM on cilia biogenesis has not been well studied. In this study we examined the effects of type I collagen (col I), the major component of ECM, on primary cilia growth...
August 12, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28796070/clinical-characteristics-of-meckel-diverticulum-in-children-a-retrospective-review-of-a-15-year-single-center-experience
#4
Xiao-Kun Lin, Xiao-Zhong Huang, Xiao-Zhou Bao, Na Zheng, Qiong-Zhang Xia, Cong-de Chen
Meckel diverticulum is the most prevalent congenital abnormality of the gastrointestinal tract in children. The aim of this study was to review and analyze clinical data on the diagnosis and management of Meckel diverticulum in pediatric patients. The records of 102 pediatric patients (<14 years old) who underwent surgery for Meckel diverticulum at our institute between 2001 and 2015 were reviewed. Clinical, imaging, laboratory, surgical, and pathological data were recorded. The series comprised 65 males and 37 females with a median age of 5...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28792510/morphological-and-taxonomic-descriptions-of-a-new-genus-and-species-of-killifishes-teleostei-cyprinodontiformes-from-the-high-andes-of-northern-chile
#5
Gloria Arratia, Irma Vila, Natalia Lam, Claudia Jimena Guerrero, Claudio Quezada-Romegialli
A new genus and species, Pseudorestias lirimensis, is described from the southern part of the Chilean Altiplano. While sharing several characters that clearly align the new species with Orestias, this new fish is characterized by numerous autapomorphies: the Meckel cartilage is a continuous cartilage that broadly expands posteriorly (in large specimens, it keeps its anterior part and is resorbed posteriorly), the basibranchials are fused into one long element, the second pharyngobranchial is not displaced dorsally over pharyngobranchial tooth plate 3+4, but they are aligned, the anterior and posterior ceratohyals are closely articulated keeping a scarce amount of cartilage between both bones and ventral to them, ossified middle and distal dorsal radials are present in females as well as ossified middle and distal anal radials...
2017: PloS One
https://www.readbyqxmd.com/read/28783116/teratogenic-effects-of-topiramate-in-a-zebrafish-model
#6
Yu-Heng Lai, Yu-Ju Ding, David Moses, Yau-Hung Chen
Topiramate is commonly used for treating epilepsy in both children and adults. Recent clinical data suggests that administration of topiramate to women during pregnancy increases the risk of oral clefts in their offspring. To better understand the potential effects of topiramate, we dosed adult female zebrafish with topiramate, and investigated the altered morphologies in adult females and their offspring. It showed that topiramate-treated female fish had reduced oocyte maturation, and the survival rates of their offspring were seriously decreased during embryogenesis...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28770124/omphalocele-and-gastroschisis-in-newborns-over-16-years-of-experience-from-a-single-clinic
#7
Shunusuke Watanabe, Tatuya Suzuki, Fujio Hara, Toshihiro Yasui, Naoko Uga, Atuki Naoe
Infants born with potentially life-threatening conditions of omphalocele and gastroschisis may require long-term hospitalization. We aimed to compare the outcomes of these two conditions occurring over a 16-year period (2001-16). It is a retrospective study of 19 newborns undergoing surgery for these two abdominal wall defects (8 patients with omphalocele and 11 cases of gastroschisis). The average birth weights for the newborns with omphaloceles and gastroschisis were 2554.5 g and 2248.6 g respectively. Associated anomalies included trisomy 18, Beckwith-Wiedemann syndrome, congenital heart disease, Meckel's diverticulum, inguinal hernias, renal deformities, limb deformities, cryptorchidism, body stalk anomalies, and closed gastroschisis...
April 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28769044/intercellular-genetic-interaction-between-irf6-and-twist1-during-craniofacial-development
#8
Walid D Fakhouri, Kareem Metwalli, Ali Naji, Sarah Bakhiet, Angela Quispe-Salcedo, Larissa Nitschke, Youssef A Kousa, Brian C Schutte
Interferon Regulatory Factor 6 (IRF6) and TWIST1 are transcription factors necessary for craniofacial development. Human genetic studies showed that mutations in IRF6 lead to cleft lip and palate and mandibular abnormalities. In the mouse, we found that loss of Irf6 causes craniosynostosis and mandibular hypoplasia. Similarly, mutations in TWIST1 cause craniosynostosis, mandibular hypoplasia and cleft palate. Based on this phenotypic overlap, we asked if Irf6 and Twist1 interact genetically during craniofacial formation...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28762108/trigeminal-neuropathy-associated-with-an-enlarging-arachnoid-cyst-in-meckel-s-cave-case-report-management-strategy-and-review-of-the-literature
#9
Mark G Bigder, Adel Helmi, Anthony M Kaufmann
We describe a rare case and novel management strategy of painful trigeminal neuropathy caused by an arachnoid cyst confined to Meckel's cave. A 57-year-old female presented with several years of progressive trigeminal pain and signs of trigeminal deafferentation, including sensory loss, corneal anesthesia and mastication muscle atrophy. Medical treatment with carbamazepine provided partial and temporary pain control. Surgical treatment was eventually performed by aspiration of the arachnoid cyst through the foramen ovale using a percutaneous approach...
July 31, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28758183/neuronavigation-guided-endoscopic-endonasal-excision-of-schwannoma-like-chordoma-of-the-meckel-s-cave-a-case-report
#10
Ali Akay, Sercan Göde, M Sedat Çağli
Chordomas are locally aggressive malignant tumors due to their recurrence potential, originating from the embryonic notochord remnants. Chordomas can originate anywhere on the axial skeleton. They are extradural and are spread by bone destruction. Chordomas are locally aggressive tumors which invade the dura mater, and may also present with secondary intradural growth. The Meckel's cave location of chordomas has been very rarely reported in the literature. Chordomas located in the Meckel's cave can be radiologically confused with trigeminal schwannomas...
June 14, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28757668/perceiving-emotion-in-non-social-targets-the-effect-of-trait-empathy-on-emotional-contagion-through-art
#11
Olga Stavrova, Andrea Meckel
This research examines the role of trait empathy in emotional contagion through non-social targets-art objects. Studies 1a and 1b showed that high- (compared to low-) empathy individuals are more likely to infer an artist's emotions based on the emotional valence of the artwork and, as a result, are more likely to experience the respective emotions themselves. Studies 2a and 2b experimentally manipulated artists' emotions via revealing details about their personal life. Study 3 experimentally induced positive vs...
2017: Motivation and Emotion
https://www.readbyqxmd.com/read/28756053/-patients-with-ulcerative-colitis-and-primary-sclerosing-cholangitis-frequently-have-subclinical-inflammation-in-the-proximal-colon
#12
Noa Krugliak Cleveland, David T Rubin, John Hart, Christopher R Weber, Katherine Meckel, Anthony L Tran, Arthur S Aelvoet, Isabella Pan, Alex Gonsalves, John Nick Gaetano, Kelli Williams, Kristen Wroblewski, Bana Jabri, Joel Pekow
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) patients with ulcerative colitis (UC) have a high risk of colonic neoplasia. As histologic inflammation is an independent risk factor for the development of neoplasia, we hypothesized that patients with UC and PSC have more subclinical disease activity than patients with UC alone. METHODS: We performed a retrospective evaluation of patients with ulcerative pancolitis who were in clinical remission and compared endoscopic and histologic activity between those with and without PSC...
July 26, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28752148/a-condition-that-should-be-kept-in-mind-in-incarcerated-hernia-amyand-s-hernia
#13
Mehmet Bugra Bozan, Fatih Mehmet Yazar, Fatih Erol, Evrim Gul, Omer Dogan Alatas
As a complication of inguinal hernia, incarcerations are often seen in emergency services. Incarceration is an acute complication of inguinal hernia presenting as surgical emergency. The sac of inguinal hernia most frequently contains omentum and intestine but sometimes organs such as appendix and Meckel's diverticulum can also be seen in the hernial sac. We present a case of Amyand's hernia containing appendix in the incarcerated herniated sac.
2017: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/28749258/coelomic-teratoma-in-a-blue-and-yellow-macaw-ara-ararauna
#14
Letícia B de Oliveira, Willian H M Santos, Alessandra V de Araújo, Anelise C Nepomuceno, Roselene Ecco
A 2-mo-old, female blue-and-yellow macaw (Ara ararauna) presented with severe abdominal distension, pain, and respiratory distress. Ultrasonographic examination detected a heterogeneous mass with multiple anechoic areas, compatible with a multilocular cyst, occupying most of the coelomic cavity. Postmortem examination revealed a mass of 12.0 × 8.5 × 5.0 cm, which had an irregular surface and was connected by a pedicle to the ileum. This mass compressed and displaced the liver, proventriculus, gizzard, and intestines cranially to the left...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28744739/perforated-meckel-s-diverticulitis
#15
Robert W Colvin, Sayf Al-Katib, John Ebersole
A Meckel's diverticulum is a vestigial remnant present in approximately 2% of the population. Fewer than 10% of patients with a Meckel's diverticulum develop clinical complications, and such findings are exceedingly rare in the geriatric population. We present a case of perforated Meckel's diverticulitis with a fistulous tract involving the anterior abdominal wall in an 85-year-old male.
July 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28739515/the-trigeminocardiac-reflex-during-the-anterior-transpetrosal-approach
#16
Shunsuke Shibao, Karam Kenawy, Hamid Borghei-Razavi, Kazunari Yoshida
OBJECTIVE: The anterior transpetrosal approach (ATPA), during which the trigeminal nerve (TN) is manipulated, has a risk of eliciting the trigeminocardiac reflex (TCR). The aim of this study was to assess the risk of TCR during ATPA. METHODS: Surgical records of 92 patients who had surgical treatment via ATPA at the Keio University Hospital between December 2005 and June 2015 were retrospectively analyzed. Patients were divided into 2 groups on the basis of the occurrence of TCR during surgery, and clinical and tumor characteristics were compared...
July 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735118/giant-meckel-s-diverticulum-compressing-root-of-mesentery-a-rare-cause-of-ileal-gangrene-case-report-and-review-of-literature
#17
Mohammed Farooq, Aashish Rajesh
INTRODUCTION: Meckel's diverticulum (MD) commonly presents as gastrointestinal bleeding in the pediatric population and intestinal obstruction in adults. There is no consensus for surgical excision of an incidentally diagnosed MD. We present a hitherto unreported vascular cause of intestinal gangrene due to MD. CASE PRESENTATION: A 16year old boy was referred as an acute abdomen for tertiary hospital management. Clinical examination and CT suggested small bowel obstruction and emergency laparotomy was performed...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28732299/enterovesical-fistula-a-rare-complication-of-meckel-s-diverticulum-a-case-report
#18
Bourguiba M A, Gharbi M, Ghalleb M, Ben Taher A, Souai F, Bensafta Y, Sayari S, Ben Moussa M
INTRODUCTION: Enterovesical fistulas usually result from diverticulitis, Crohn's disease, or colorectal cancer. A perforated Meckel's diverticulum can exceptionally result in an vesico-diverticulum fistula, as noted in only seven previously reported cases. CASE REPORT: A 35-year old Arabic male, quadriplegic,who presented epigastralgia evolving for a week, associated with abdominal distension and cloudy urine. On examination he was feverish (38.5°C), dehydrated with tenderness in the entire distended abdomen; rectal examination revealed a hypotonic sphincter with no other abnormality...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28731997/perforated-meckel-s-diverticulum
#19
Janaina Gatto, Jonas Takada, Jose P Otoch, Fernanda Kreve, Francisco S Loss, Everson L A Artifon
We report a patient with diffuse peritonitis due to perforation of Meckel's diverticulum. This patient was referred to the operating room and underwent bowel resection segment encompassing the area of the diverticulum and terminoterminal primary enteroanastomosis on two levels with good evolution. The diverticulum complications are often related to the presence of ectopic mucosa, specially the gastric and pancreatic type. Since preoperative diagnosis is difficult and infrequent, in most cases this anomaly is confirmed only during surgery...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28726664/expanded-phenotype-of-tmem67-gene-mutation-case-report
#20
T Tkemaladze, G Melikishvili, V Kherkheulidze, A Melikishvili, T Davitaia
Human ciliopathies are a class of multi-organ genetic disorders caused by defects of proteins expressed at the primary cilium, an organelle present on the cell surface of almost all cell types. Thus far, dozens of causative genes for ciliopathies have been identified and many of them are known to cause allelic disease. Of particular interest is the TMEM67 gene, encoding the transmembrane protein meckelin. The involvement of the mutant TMEM67 gene is known to be associated with a broad range of clinical presentations, namely Joubert syndrome 6 (JBTS6), nephronophthisis 11 (NPHP11), Bardet-Biedel syndrome (BBS), COACH syndrome, and lethal Meckel syndrome type 3 (MKS3)...
June 2017: Georgian Medical News
keyword
keyword
56994
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"