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https://www.readbyqxmd.com/read/29242825/hydraulic-fracturing-and-infant-health-new-evidence-from-pennsylvania
#1
Janet Currie, Michael Greenstone, Katherine Meckel
The development of hydraulic fracturing ("fracking") is considered the biggest change to the global energy production system in the last half-century. However, several communities have banned fracking because of unresolved concerns about the impact of this process on human health. To evaluate the potential health impacts of fracking, we analyzed records of more than 1.1 million births in Pennsylvania from 2004 to 2013, comparing infants born to mothers living at different distances from active fracking sites and those born both before and after fracking was initiated at each site...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29209597/meckel-gruber-syndrome-an-update-on-diagnosis-clinical-management-and-research-advances
#2
REVIEW
Verity Hartill, Katarzyna Szymanska, Saghira Malik Sharif, Gabrielle Wheway, Colin A Johnson
Meckel-Gruber syndrome (MKS) is a lethal autosomal recessive congenital anomaly syndrome caused by mutations in genes encoding proteins that are structural or functional components of the primary cilium. Conditions that are caused by mutations in ciliary genes are collectively termed the ciliopathies, and MKS represents the most severe condition in this group of disorders. The primary cilium is a microtubule-based organelle, projecting from the apical surface of vertebrate cells. It acts as an "antenna" that receives and transduces chemosensory and mechanosensory signals, but also regulates diverse signaling pathways, such as Wnt and Shh, that have important roles during embryonic development...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29208031/lipid-rafts-remain-stable-even-after-ionizing-radiation-induced-disintegration-of-%C3%AE-1-integrin-containing-focal-adhesions
#3
Laura Babel, Larissa Kruse, Steven Bump, Markus Langhans, Tobias Meckel
OBJECTIVE: Adhesion of cells to the extracellular matrix is facilitated by integrin receptors. We recently found that a nanoscale organization of plasma membrane located integrins containing the β1 subunit is responsible for an enhanced radio-resistance in 3D cultured cells over cells grown in 2D. While ionizing radiation is known to have broad effects on the lipid composition of the plasma membrane and their organization in lipid-rafts, it is not clear whether the effects of ionizing radiation on the nanoscale clustering of integrins is lipid-raft dependent...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29207775/axial-torsion-of-meckel-s-diverticulum-a-rare-case-report
#4
Sandesh Vithal Parab, Pramod Govindrao Salve, Aruna Dahiphale, Rupesh Thakare, Amit Aiwale
Meckel's Diverticulum (MD) is the most common congenital anomaly of gastrointestinal tract, occurring in 2% of the population. It is a true diverticulum and histologically all four intestinal layers are present within MD. There are various complications related to a Meckel's diverticulum, including haemorrhage, intestinal obstruction, inflammation and perforation. Axial torsion followed by gangrene of MD is the rarest of the complications that have been reported. The exact mechanism for torsion is unclear. Preoperative diagnosis of torsion of MD is difficult and often confused with appendicitis as pain is usually localized to right lower quadrant...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29188303/analysis-of-petrous-apex-meningocele-associated-with-meningioma-is-there-any-relation-with-chronic-intracranial-hypertension
#5
Wan-Qun Yang, Jie-Ying Feng, Hong-Jun Liu, Biao Huang, Chang-Hong Liang
PURPOSE: Petrous apex meningocele (PAM) is an uncommon cystic lesion involving the petrous apex. The underlying cause of PAM may be related to chronic elevated intracranial pressure. The aim of the study was to explore the relationship between PAM and meningioma and between PAM and other intracranial hypertension findings. METHODS: Two hundred seventy-eight consecutive patients with meningiomas were retrospectively studied. Fifty age- and gender-matched controls were also enrolled in this study...
November 29, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29169085/combined-toxicity-of-triclosan-2-4-dichlorophenol-and-2-4-6-trichlorophenol-to-zebrafish-danio-rerio
#6
Yuhuan Zhang, Mi Liu, Jinfeng Liu, Xuedong Wang, Caihong Wang, Weiming Ai, Shaobo Chen, Huili Wang
Triclosan (TCS), 2,4,6-trichlorophenol (2,4,6-TCP) and 2,4-dichlorophenol (2,4-DCP) are the most prevalent chlorinated phenolic pollutants in aquatic environments. Our results showed LC50 and EC50 values of 0.51, 1.11, 2.45mg/L, and 0.36, 0.74, 1.53mg/L for TCS, 2,4,6-TCP and 2,4-DCP, respectively, to 120hpf zebrafish. The highest TCSD (the mixture of TCS, 2,4,6-TCP and 2,4-DCP) toxicity was observed at a TCS:2,4,6-TCP:2,4-DCP concentration ratio of 1:2:4. LC50 and EC50 values of TCSD mixtures for 120-hpf zebrafish were 2...
November 20, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29168644/hemorrhage-and-intestinal-obstruction-secondary-to-a-meckel-s-diverticulum-a-case-report
#7
Bing Yan Xue, Qi Yun Tang
We present one case of a 17-year-old male with ten-year history of anemia complaining of recurrent bloody stools, abdominal pain and fatigue for 3 months.The gastroscopy, colonoscopy, the-first-time double-balloon enteroscopy (DBE) through the anus and capsule endoscopy were performed with negative results. 99mTc-pertechnetate scan showed a round-like high radioactive concentration at the ileocecum. Double-balloon enteroscopy through the anus was performed again by a more-experienced endoscopic physician, the diverticulum was found at a distance of 50 cm to the ileocecal valve...
November 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29148196/umbilicus-and-its-extensive-clinical-repertoire
#8
Spencer W Beasley
The umbilicus is involved in a wide range of abnormalities in infants and children. The most severe are evident at birth and include exomphalos (omphalocele) and gastroschisis, both of which can be life-threatening but are easy to diagnose. Exomphalos is often associated with other congenital abnormalities, whereas the associated problems in gastroschisis are largely confined to the gut. Infection of the umbilicus in the neonate presents as omphalitis. The causes of a moist umbilicus following separation of the umbilical stump are multiple, from the relatively minor umbilical granuloma or ectopic bowel mucosa to the more significant patent urachus that leaks urine...
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29145243/obstructive-internal-hernia-caused-by-mesodiverticular-bands-in-children-two-case-reports-and-a-review-of-the-literature
#9
Mirko Bertozzi, Berardino Melissa, Elisa Magrini, Giuseppe Di Cara, Susanna Esposito, Antonino Apignani
INTRODUCTION: The mesodiverticular band (MDB) is an embryologic remnant of the vitelline circulation, which carries the arterial supply to the Meckel diverticulum. In the event of an error of involution, a patent or nonpatent arterial band persists and extends from the mesentery to the apex of the antimesenteric diverticulum. This creates a snare-like opening through which bowel loops may herniate and become obstructed. This report describes 2 rare cases of small bowel occlusion owing to an internal hernia caused by a MDB...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142361/tubular-intestinal-duplication-harboring-gastric-ectopia-accurately-diagnosed-by-tc-99m-pertechnetate-single-photon-emission-computed-tomography-computed-tomography-meckel-s-scan
#10
Ioannis Spyridakis, Domenica Lopresti, Stamata Georga, Chrysostomos Kepertis, Ioannis Efstratiou, Georgios Arsos
A 7-year-old girl with an episode of hematochezia and melena, suspicious for bleeding Meckel's diverticulum, was referred for a Tc-99m pertechnetate Meckel's scan. On dynamic planar scan, apart from prompt gastric visualization an oval-shaped, area of inhomogeneous tracer uptake was observed in the left lower quadrant of the abdomen. Subsequent single-photon emission computed tomography/computed tomography localized this to intestinal lumen, thus establishing the diagnosis of intestinal duplication (ID) with functional gastric mucosa...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29135804/surgical-management-of-tumors-involving-meckel-s-cave-and-cavernous-sinus-role-of-an-extended-middle-fossa-and-lateral-sphenoidectomy-approach
#11
Daniel Q Sun, Arnold H Menezes, Matthew A Howard, Bruce J Gantz, David M Hasan, Marlan R Hansen
OBJECTIVE: To study the indications and outcomes of lateral sphenoidectomy as part of a combined skull base approach in the treatment of tumors involving Meckel's cave (MC) and cavernous sinus (CS). STUDY DESIGN: Retrospective patient series. SETTING: Tertiary referral center. PATIENTS: Twenty-two consecutive patients (mean age: 45 yr, range: 16-76) who underwent transzygomatic, extended middle fossa approaches for tumors involving MC and CS...
November 13, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29129769/retrosigmoid-intradural-suprameatal-inframeatal-approach-for-complete-surgical-removal-of-a-giant-recurrent-vestibular-schwannoma-with-severe-petrous-bone-involvement-technical-case-report
#12
Yosuke Sato, Tohru Mizutani, Katsuyoshi Shimizu, Hans-Joachim Freund, Madjid Samii
BACKGROUND: Surgical removal of giant vestibular schwannomas with severe petrous bone involvement remains challenging due to the high risk of complications. The retrosigmoid intradural suprameatal-inframeatal approach (RISIA) allows for safe exposure extending from Meckel's cave to the petrous internal carotid artery (ICA). CLINICAL DESCRIPTION: A 27-year-old man presented with recurrence of a giant vestibular schwannoma (4.5 cm) invading Meckel's cave and the left petrous ICA...
November 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29127243/pelvic-meckel-s-diverticulum-mimicking-bladder-on-meckel-scan-the-impact-of-quality-control-and-technical-issues
#13
Mohsen Qutbi, Isa Neshandar Asli
Quality control and technical issues are essential for high-quality imaging. An important technical parameter of image acquisition is selecting zoom factor according to camera field-of-view dimensions and patient's body size. Here, we present a case of atypically located Meckel's diverticulum mimicking bladder on Meckel scan.
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29123444/imaging-findings-of-the-unusual-presentations-associations-and-clinical-mimics-of-acute-appendicitis
#14
REVIEW
Mustafa Kemal Demir, Yildiray Savas, Yavuz Furuncuoglu, Tarik Cevher, Serdar Demiral, Babek Tabandeh, Melisa Aslan
There are many kinds of unusual presentations or associations and clinical mimics of acute appendicitis, and definitive diagnosis requires knowledge of the imaging findings in some cases. The unusual presentations and associations of acute appendicitis included in this study are perforated appendicitis, acute appendicitis occurring in hernias, acute appendicitis with cystic endosalpingiosis, intussusception of appendix, and acute appendicitis with pregnancy. We also present uncommon gastrointestinal, urinary and gynecologic clinical mimics of acute appendicitis including anomalous congenital band, duplication cysts, giant Meckel's diverticulitis, inflammatory fibroid polyp, renal artery thrombosis, spontaneous urinary extravasation and OHVIRA syndrome...
October 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29109349/-a-case-of-an-elderly-patient-with-inverted-meckel-s-diverticulum-with-small-intestinal-bleeding-detected-using-capsule-and-double-balloon-endoscopies
#15
Takashi Ibuka, Hiroshi Araki, Tomohiko Sugiyama, Jun Takada, Masaya Kubota, Youhei Shirakami, Makoto Shiraki, Masahito Shimizu, Natsuko Suzui, Tatsuhiko Miyazaki
An 80-year-old man was examined with esophagogastroduodenoscopy and colonoscopy because of digestive tract hemorrhage;however, no specific cause was found. Small intestinal capsule endoscopy revealed a reddish elevated lesion in the ileum. This lesion was also detected using double-balloon endoscopy as a 5-cm reddish elevated lesion covered with normal villous architecture in the 95-cm part of the Bauhin valve on the oral side. The lesion was laparoscopically resected and diagnosed as inverted Meckel's diverticulum based on pathological examination...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29107196/high-prevalence-of-the-igf2-rs680-gg-polymorphism-among-top-level-sprinters-and-jumpers
#16
Sigal Ben-Zaken, Yoav Meckel, Dan Nemet, Alon Eliakim
Previous studies have shown that the IGF1 polymorphism is associated with greater muscle mass and improved power athletic ability, but very little is known about the IGF2 polymorphism and athletic performance. PURPOSE: The aim of the present study was to assess the frequency distribution of the IGF2 rs680 polymorphism among Israeli athletes. METHODS: 185 short- (n=72) and long-distance (n=113) runners, 94 short- (n=44) and long-distance (n=50) swimmers, 54 weight lifters and 111 controls participated in the study...
December 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29103471/bleeding-meckel-s-diverticulum-a-study-of-the-accuracy-of-pertechnetate-scintigraphy-as-a-diagnostic-tool
#17
Iain Irvine, Ailbhe Doherty, Roisin Hayes
BACKGROUND: The reported accuracy of pertechnetate scintigraphy (Meckel scan) in investigating children with a bleeding Meckel's diverticulum has increased steadily since it was first introduced into clinical practice in 1970. Recent studies have indicated that the examination has a sensitivity of up to 94% and a specificity of up to 97% in this scenario. There have also been several misleading reviews from Departments of Surgery, suggesting that the Meckel scan has a poor predictive value, and should not be relied upon to exclude a bleeding Meckel's Diverticulum (MD)...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29078157/a-case-of-retroperitoneal-abscess-a-rare-complication-of-meckel-s-diverticulum
#18
Jeana Hong, Sung Bae Park
INTRODUCTION: The frequent complications of Meckel's diverticulum are hemorrhage, intestinal obstruction, and inflammation, and perforation. The presentation as a retroperitoneal abscess as complications of Meckel's diverticulum is a very rare clinical entity. PRESENTATION OF CASE: We report a rare case of perforated Meckel's diverticulum with retroperitoneal abscess. A 31-year-old presented with a half-hour history of severe epigastric pain and diffuse periumbilical pain...
October 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29076905/aspiration-incidentally-detected-by-a-meckel-scintigraphy
#19
Xia Bai, Johannes C Fostitsch, Hongming Zhuang
Meckel scintigraphy with Tc-pertechnetate was performed in a 5-year-old boy to determine whether a Meckel diverticulum containing ectopic gastric mucosa caused bleeding. The images did not reveal focal activity characteristic of a Meckel diverticulum. Unexpectedly, activity in the tracheobronchial tree was visualized, consistent with aspiration of the radioactive saliva.
October 26, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29070777/calcification-in-rat-developing-mandibular-bone-demonstrated-by-whole-mount-staining-microcomputed-tomography-and-scanning-electron-microscopy-with-energy-dispersive-x-ray-spectroscopy
#20
Akiko Henmi, Hiroshi Okata, Yasuto Mikami, Yasuyuki Sasano
The study was designed to investigate calcification in developing rat mandibular bone using whole mount staining, micro-computed tomography (micro-CT) and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX). Wistar rats at embryonic days 16, 18, and 20 and postnatal weeks 1 and 6 were used. Rats were fixed with 4% paraformaldehyde and heads were resected, frozen and sectioned for histology, then analysed with SEM-EDX. Some of the specimens were observed with micro-CT. Other rats were fixed and stained with alcian blue and alizarin red for whole mount staining...
2017: Biomedical Research
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