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Eva Pamias-Portalatin, Deependra Mahato, Jordina Rincon-Torroella, Tito Vivas-Buitrago, Alfredo Quiñones-Hinojosa, Kofi O Boahene
Clival lesions are still considered surgically complex due to their anatomical location. Critical structures, such as the internal carotid arteries (ICAs), cavernous sinuses, cranial nerves, and brainstem, may be encased within the lesion. Although advances in endoscopic endonasal approaches have provided new routes to these lesions, exposure and resection of clival tumors through the endonasal route remain a technical challenge. Here, the authors report a left-sided endoscopic transmaxillary approach to access the right aspect of the clivus and the hypoglossal canal...
June 22, 2018: Journal of Neurosurgery
A Ioannidis, I Karanikas, C Koutserimpas, G Velimezis
Littre hernia is defined as the herniation of a Meckel's diverticulum, while Richter's hernia is the herniation of a portion of the bowel wall. An extremely rare case of a combined Littre and Richter's femoral hernia is reported. An 82-year-old male presented at the emergency department with a painful golf ball-like mass at the right inguinofemoral region. With the diagnosis of incarcerated femoral hernia, he was urgently taken to the operating room. Intraoperatively, an incarcerated Littre, as well as a Richter's hernia were revealed...
May 2018: Il Giornale di Chirurgia
Thomas Pirzer, Kira-Sophie Becher, Marcel Rieker, Tobias Meckel, Henning D Mootz, Harald Kolmar
Cell targeting protein toxins have gained increasing interest for cancer therapy, aimed at increasing the therapeutic window and to reduce systemic toxicity. Since recombinant expression of immunotoxins consisting of a receptor-binding and a cell-killing moiety is hampered by their high toxicity in an eukaryotic production host, most applications rely on recombinant production of fusion proteins consisting of an antibody fragment and a protein toxin in bacterial hosts such as Escherichia coli (E. coli). These fusions often lack beneficial properties of whole antibodies like extended serum half-life or efficient endocytic uptake via receptor clustering...
June 19, 2018: ACS Chemical Biology
Hiroyuki Hakoda, Hideyuki Mishima, Takumi Habu, Shin Murai, Ryohei Maeno, Yuriko Yokomizo, Yuki Inagaki, Takehito Maruyama, Yuichi Matsui, Akihiro Sako
While there have been numerous reports about colovesical fistulas and ruptured intestinal diverticula, there have been far fewer reports about vesicointestinal fistulas caused by Meckel's diverticula. Most Meckel's diverticula are asymptomatic. Furthermore, they seldom cause vesicointestinal fistulas, and the associated complications are non-specific. Thus, their preoperative diagnosis is difficult. We experienced a case in which a vesicointestinal fistula was caused by a Meckel's diverticulum and was treated with laparoscopic surgery...
June 18, 2018: Clinical Journal of Gastroenterology
Patrick S Phelan, Jamie L Mull, Mohamed Z Rajput, Amy C Musiek
We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement...
June 17, 2018: BMJ Case Reports
Yoav Meckel, Ofer Doron, Eyal Eliakim, Alon Eliakim
The aim of the study was to investigate seasonal variations in fitness and performance indices of professional male soccer players. Eighteen professional male soccer players (age range 22⁻32 years) completed three similar sets of tests at three stages of the season: before preseason; after preseason and the middle of the competitive in-season. A significant decrease in body mass and percent fat was found during the preseason. A significant improvement ( p < 0.05) was found in the vertical jump (preseason: 37...
February 13, 2018: Sports
Jean-Philippe Le Mouel, Julie Morvan, Mathurin Fumery, Sami Hakim, Richard Delcenserie, Denis Chatelain, Eric Nguyen-Khac
No abstract text is available yet for this article.
June 12, 2018: Endoscopy
Hiroyuki Kubo, Atsushi Ikeda, Tsuyoshi Otani, Yasuhide Ishikawa
No abstract text is available yet for this article.
May 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Abib Diop, Ousmane Thiam, Mouhamadou Lamine Guèye, Mamadou Seck, Alpha Oumar Touré, Mamadou Cissé, Madieng Dieng
We conducted a retrospective study of 15 patients with complicated Meckel diverticula treated in the emergency surgery at the Aristide Le Dantec Hospital, Dakar, over a period of 13 years (January 2003-June 2016). The study included 10 men and 5 women, whose average age was 27.8 years, ranging between 1 months and 73 years. The two main circumstances of detection were occlusive syndrome and peritoneal irritation. Emergency laparotomy allowed clinicians to affirm the involvement of Meckel diverticulum in the clinical picture...
2018: Pan African Medical Journal
Vipul D Yagnik
No abstract text is available yet for this article.
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
Zi Yang Jiang, Caitlin McLean, Carlos Perez, Samuel Barnett, Deborah Friedman, Bobby A Tajudeen, Pete S Batra
Background  The etiology of spontaneous cerebrospinal fluid (CSF) rhinorrhea remains unknown, though emerging evidence suggests that this likely represents a variant of idiopathic intracranial hypertension. Long-term success rates for repair and postoperative management strategies remain variable. Methods  Retrospective review of patients undergoing surgical management of spontaneous CSF rhinorrhea was conducted over a 5-year period. Analysis was performed to correlate recurrence with demographics and perioperative variables...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Lawrance K Chung, Carlito Lagman, Courtney Duong, Daniel T Nagasawa, Alexander M Tucker, William H Yong, Isaac Yang
Objective  Dermoid cysts are benign, congenital malformations that account for ∼0.5% of intracranial neoplasms. The authors describe a 42-year-old female with a prepontine dermoid cyst who underwent apparent gross total resection (GTR) but experienced cyst recurrence. To date, very few cases of prepontine dermoid cysts have been reported. The prevalent region where these cysts are located can be difficult to determine. In addition, the authors systematically review the literature to characterize the clinical presentation, anatomical distribution, and surgical outcomes of intracranial dermoid cysts...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Rueyhung Roc Weng, T Tony Yang, Chia-En Huang, Chih-Wei Chang, Won-Jing Wang, Jung-Chi Liao
The primary cilium is an essential organelle mediating key signaling activities, such as sonic hedgehog signaling. The molecular composition of the ciliary compartment is distinct from that of the cytosol, with the transition zone (TZ) gated the ciliary base. The TZ is a packed and organized protein complex containing multiple ciliopathy-associated protein species. Tectonic 2 (TCTN2) is one of the TZ proteins in the vicinity of the ciliary membrane, and its mutation is associated with Meckel syndrome. Despite its importance in ciliopathies, the role of TCTN2 in ciliary structure and molecules remains unclear...
June 1, 2018: Biophysical Journal
Adrian Mancini, Fabian Reche, Jean-Luc Faucheron
No abstract text is available yet for this article.
May 29, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
A V Pugaev, E E Achkasov, M G Negrebov, L V Alexandrov, S F Alekperov, V I Posudnevsky, D M Pugaev, M V Kolpakov
AIM: To evaluate the effectiveness of complex preoperative diagnostics and medication of intussusception followed by intestinal obstruction in adults with the choice of surgical repair and analysis of the outcomes depending on the causes of intussusception. MATERIAL AND METHODS: 15 intussusception patients aged 19 - 86 years were enrolled. Mean age was 52.7 years. Patients were hospitalized within 12 hours - 1-2 weeks after onset of the disease. Diagnosis was established on the basis of complaints, anamnesis, objective and additional survey...
2018: Khirurgiia
Y Xu, S D Qiao, W G Huang, J H Qiu
Objective: To privde anatomical basis for the surgical operation of endoscope-assisted retrosigmoid approach. Method: In 20 adult head cadavers fixed with formalin (40 sides), the surgery via retrosigmoid approach was simulated. The anatomic features of the cerebellopontine angle were examined and measured. Result: The distance from the midpoint of posterior border of sigmoid sinus to acoustic nerve near internal acoustic pore, trigeminal nerve near Meckel's cave, glossopharyngeal nerve near jugular foramen and the posterior margin of internal acoustic meatus were (32...
December 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
M Anthony Sofia, Matthew A Ciorba, Katherine Meckel, Chai K Lim, Gilles J Guillemin, Christopher R Weber, Marc Bissonnette, Joel R Pekow
Background and Aims: Mucosal appearance on endoscopy is an important indicator of inflammatory burden and determines prognosis in ulcerative colitis (UC). Inflammation induces tryptophan metabolism along the kynurenine pathway (KP) and yields immunologically relevant metabolites. We sought to examine whether changes in serum tryptophan metabolites and tissue expression of KP enzymes are associated with UC endoscopic and histologic disease severity. Methods: Serum and mucosal samples were prospectively obtained at colonoscopy in patients with UC...
May 22, 2018: Inflammatory Bowel Diseases
Mélodie Juricic, Damipi Yempab Djagbare, Marion Carmassi, Nicoleta Panait, Alice Faure, Oumar NDour, Gabriel NGom, Thierry Merrot
Ectopic pancreas also known as heterotopic pancreas (HP) is a rare congenital anomaly, mainly found as incidental finding during autopsy or abdominal exploration for an other condition. Incidence rate is probably underestimated as patients are mostly asymptomatic; otherwise, it is capable of producing symptoms depending on its location, size, often appearing in the 4th-to-6th decades. Complications such as inflammation, obstruction, bleeding, and malignancy degeneration must be considered. Pediatrics cases are very rare, generally concerning HP within Meckel's diverticulum, manifesting by gastrointestinal bleeding and intussusception...
May 21, 2018: Surgical and Radiologic Anatomy: SRA
Kazuhide Adachi, Mituhiro Hasegawa, Shinichiro Tateyama, Yushi Kawazoe, Yuichi Hirose
OBJECTIVE: The anterior transpetrosal (ATP) approach is the most appropriate approach for petroclival meningiomas, which are typically located from the dorsum sellae to the upper border of the internal acoustic meatus (IAM). Although neurosurgeons can resect over this area if the tumor is detached from the dura, tumors within the indication area for petroclival meningiomas is insufficient for the selection of the ATP approach because it can be difficult to evaluate whether the tumor is attached or only touching the dura...
May 16, 2018: World Neurosurgery
Ali Tayebi Meybodi, Andrew S Little, Vera Vigo, Arnau Benet, Sofia Kakaizada, Michael T Lawton
OBJECTIVE The transpterygoid extension of the endoscopic endonasal approach provides exposure of the petrous apex, Meckel's cave, paraclival area, and the infratemporal fossa. Safe and efficient localization of the lacerum segment of the internal carotid artery (ICA) is a crucial part of such exposure. The aim of this study is to introduce a novel landmark for localization of the lacerum ICA. METHODS Ten cadaveric heads were prepared for transnasal endoscopic dissection. The floor of the sphenoid sinus was drilled to expose an extension of the pharyngobasilar fascia between the sphenoid floor and the pterygoid process (the pterygoclival ligament)...
May 18, 2018: Journal of Neurosurgery
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